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Добірка наукової літератури з теми "Vit D"

Автор: Grafiati
Опубліковано: 11 березня 2023

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Статті в журналах з теми "Vit D"

1

Kumar, Santosh, Gaffar Memon, Bagwan Das, and Pushpa Mohan. "VIT D DEFICIENCY." Professional Medical Journal 23, no. 09 (September 10, 2016): 1064–67. http://dx.doi.org/10.29309/tpmj/2016.23.09.1697.

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Objectives: To determine the outcome of vitamin deficiency in local populationof (Hyderabad), come with complaints of vague symptoms of body ache, bony pain with noco morbidity. Study design: cross-sectional study. Place and duration of study: OutpatientDepartment of Liquat University Medical Science, Hyderabad. Period: 6-2-2013 to 6-2-2015.Methodology: This is observational cross sectional study conducted at out patient’s department(LUMHS) city Hyderabad from 6-2-13 to 6-2-2015. Preliminary data was collected with the helpof self-administered questionnaires which include patient’s history and examination and bloodsample is taken for assessing level of dehydrocholecalciferol with serum calcium and routinetest. Data entered in spss 20 version, analytical software were applied for results in this study.Result: This study is conducted in 300 pts, among these 60% female and 36.7% male and 3.3%missing. Patients selected through (OPD) with consent and preformed proforma. Vitamin ddeficiency found nearly 96%in all the patient from young age to old age 4% were missing, lessthan 10 level found in 24.7%(severe deficiency), 10-20 level seen 54.7%(moderate deficiency)and 20-30 found in 14.7% (mild deficiency). Conclusion: my results shows that ( vitaminD-deficiency) is big dilemma in our community, give rise mild, moderate and severe decreasedlevel which leads complication which causing rickets in children and osteomalcia in adults,increase mortality and morbidity in local population.
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2

Mizuno, Hatsuhiko. "Vit D derivatives, Bisphosphonates." Japanese Journal of Pharmacology 67 (1995): 41. http://dx.doi.org/10.1016/s0021-5198(19)46133-7.

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3

Mandell, Erica, Gregory Seedorf, Jason Gien, and Steven H. Abman. "Vitamin D treatment improves survival and infant lung structure after intra-amniotic endotoxin exposure in rats: potential role for the prevention of bronchopulmonary dysplasia." American Journal of Physiology-Lung Cellular and Molecular Physiology 306, no. 5 (March 1, 2014): L420—L428. http://dx.doi.org/10.1152/ajplung.00344.2013.

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Vitamin D (vit D) has anti-inflammatory properties and modulates lung growth, but whether vit D can prevent lung injury after exposure to antenatal inflammation is unknown. We hypothesized that early and sustained vit D treatment could improve survival and preserve lung growth in an experimental model of bronchopulmonary dysplasia induced by antenatal exposure to endotoxin (ETX). Fetal rats (E20) were exposed to ETX (10 μg), ETX + Vit D (1 ng/ml), or saline (control) via intra-amniotic (IA) injections and delivered 2 days later. Newborn pups exposed to IA ETX received daily intraperitoneal injections of vit D (1 ng/g) or saline for 14 days. Vit D treatment improved oxygen saturations (78 vs. 87%; P < 0.001) and postnatal survival (84% vs. 57%; P < 0.001) after exposure to IA ETX compared with IA ETX alone. Postnatal vit D treatment improved alveolar and vascular growth at 14 days by 45% and 25%, respectively ( P < 0.05). Vit D increased fetal sheep pulmonary artery endothelial cell (PAEC) growth and tube formation by 64% and 44%, respectively ( P < 0.001), and prevented ETX-induced reductions of PAEC growth and tube formation. Vit D directly increased fetal alveolar type II cell (ATIIC) growth by 26% ( P < 0.001) and enhanced ATIIC growth in the presence of ETX-induced growth suppression by 73% ( P < 0.001). We conclude that antenatal vit D therapy improved oxygenation and survival in newborn rat pups and enhanced late lung structure after exposure to IA ETX in vivo, which may partly be due to direct effects on vascular and alveolar growth.
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4

Wang, Haiying, та Chuantao Li. "The General (α,3)-Path Connectivity Indices of Polycyclic Aromatic Hydrocarbons". Discrete Dynamics in Nature and Society 2018 (5 вересня 2018): 1–5. http://dx.doi.org/10.1155/2018/5702346.

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The general (α,t)-path connectivity index of a molecular graph originates from many practical problems such as three-dimensional quantitative structure-activity (3D QSAR) and molecular chirality. It is defined as Rtα(G)=∑Pt=vi1vi2⋯vit+1⊆G[d(vi1)d(vi2)⋯d(vit+1)]α, where the summation is taken over all possible paths of length t of G and we do not distinguish between the paths vi1vi2⋯vit+1 and vit+1⋯vi2vi1. In this paper, we focus on the structures of Polycyclic Aromatic Hydrocarbons (PAHn), which play a role in organic materials and medical sciences. We try to compute the exact general (α,3)-path connectivity indices of this family of hydrocarbon structures. Furthermore, we exactly derive the monotonicity and the extremal values of R3α(PAHn) for any real number α. These valuable results could produce strong guiding significance to these applied sciences.
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5

Abdulkader, Hiba, and Atheer Al-Saffar. "Assessment of Vitamin D Level in a Sample of Iraqi Obese Women." Iraqi Journal of Medical Sciences 19, no. 2 (December 31, 2021): 172–81. http://dx.doi.org/10.22578/ijms.19.2.6.

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Background: High prevalence of both vitamin D (vit. D) deficiency and obesity in world population as reported by many studies drown attention to establish the association and its direction between these two modifiable risk factors and their impact on health status which are still uncertain. Objective: To measure vit. D levels among a sample of obese women, describing some factors that may contribute for vit. D values in this sample and assess the correlation between vit. D levels and body mass index (BMI). Methods: A cross-sectional study was carried out among 100 obese women. Their age ranged between (20-50) years, during the period from 1st February to 1st August 2019. The sample was gathered from laboratory of private medical center at Palestine Street in Baghdad. vit. D was measured by (Ichroma vit D), which is a fluorescence immunoassay. Results: The mean±SD of vit. D values of the participants were found to be (16.05±6.9) ng/ml. Only two women from the sample had sufficient vit. D level of more than 30 ng/ml, (72%) of the participants found to have insufficient vit. D level 10-29.9 ng/ml and the remaining had deficiency in vit. D level <10 ng/ml. A significant association was found between vit. D levels and the age participants and beverages drinking (P≤0.01). Indirect correlation was found between vit. D values of the participants, their BMI values, and waist/ hip ratios and was significant with the last P≤0.012. Conclusion: No association was found between vit. D and BMI, but there is indirect correlation between vit. D and waist/hip ratio. Highest deficiency of vit. D among age group (30-39) years old and among those who were drinking carbonated beverage. Keywords: Obese, women, vitamin D, body mass index Citation: Abdulkader HD, Al-Saffar AJ. Assessment of vitamin D level in a sample of Iraqi obese women. Iraqi JMS. 2021; 19(2): 172-181. doi: 10.22578/IJMS.19.2.6
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6

Taş, Sibel, Emre Sarandöl, and Melahat Dirican. "Vitamin B6 Supplementation Improves Oxidative Stress and Enhances Serum Paraoxonase/Arylesterase Activities in Streptozotocin-Induced Diabetic Rats." Scientific World Journal 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/351598.

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The purpose of this study was to investigate the effects of vitamin B6 (Vit B6) on oxidant and antioxidant status in streptozotocin-induced diabetic rats. Thirty-two Wistar rats were divided into four groups: control (C), control + Vit B6 group (C + Vit B6), diabetes (D), and diabetes + Vit B6 group (D + Vit B6). Vit B6 (4 mg/kg body weight) was administered in drinking water for 4 weeks after the induction of diabetes. Vitamin B6 reduced serum total cholesterol level in the C + Vit B6 (P< 0.01) and D + Vit B6 (P< 0.05) groups. Plasma and tissue malondialdehyde levels were reduced in the C + Vit B6 and D + Vit B6 groups. Whole blood glutathione peroxidase (GSH-Px) and erythrocyte superoxide dismutase (SOD) activities were higher in the D group (P< 0.05). GSH-Px and SOD activities were increased in C + Vit B6 group while these parameters decreased in the D + Vit B6 group. Paraoxonase and arylesterase activities were decreased in the D group while they were increased in C + Vit B6 and D + Vit B6 groups. The results of present study suggest that vitamin B6 supplementation might be a promising adjunctive agent for improving oxidative stress and metabolic disturbances and for preventing diabetic complications including atherogenesis.
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7

Holick, Michael F., Luciana Mazzei, Sebastián García Menéndez, Virna Margarita Martín Giménez, Fatme Al Anouti, and Walter Manucha. "Genomic or Non-Genomic? A Question about the Pleiotropic Roles of Vitamin D in Inflammatory-Based Diseases." Nutrients 15, no. 3 (February 2, 2023): 767. http://dx.doi.org/10.3390/nu15030767.

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Vitamin D (vit D) is widely known for its role in calcium metabolism and its importance for the bone system. However, various studies have revealed a myriad of extra-skeletal functions, including cell differentiation and proliferation, antibacterial, antioxidant, immunomodulatory, and anti-inflammatory properties in various cells and tissues. Vit D mediates its function via regulation of gene expression by binding to its receptor (VDR) which is expressed in almost all cells within the body. This review summarizes the pleiotropic effects of vit D, emphasizing its anti-inflammatory effect on different organ systems. It also provides a comprehensive overview of the genetic and epigenetic effects of vit D and VDR on the expression of genes pertaining to immunity and anti-inflammation. We speculate that in the context of inflammation, vit D and its receptor VDR might fulfill their roles as gene regulators through not only direct gene regulation but also through epigenetic mechanisms.
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8

Frank, Alexandra, Mikel Stiffler-Joachim, Jennifer Sanfilippo, Cory Call, Matthew Dooley, Scott Hetzel, Margaret Brooks, and Andrea Spiker. "Poster 127: Vitamin D levels and Musculoskeletal Injuries in Collegiate Athletes." Orthopaedic Journal of Sports Medicine 10, no. 7_suppl5 (July 1, 2022): 2325967121S0068. http://dx.doi.org/10.1177/2325967121s00688.

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Objectives: Vitamin D (Vit D) deficiency has been identified as a global epidemic, sparking numerous studies into its more detailed effects on the body. In orthopedics, Vit D deficiency has been found to correlate with an increase in a variety of musculoskeletal injuries. Although current evidence suggests a connection between the number of musculoskeletal injuries sustained and an athlete’s vitamin D level, this correlation has not yet been thoroughly investigated in the collegiate athlete population. We hypothesized that lower levels of serum vitamin D would be associated with an increased number of musculoskeletal injuries and increased recovery time. Methods: A retrospective study was performed on 285 student athletes at the authors’ institution, a Division I university (Table 1). Serum 25-hydroxyvitamin D (25(OH)D) levels obtained on each athlete via chart review in conjunction with the athletic department and categorized into normal (≥32 ng/mL), insufficient (20 to 31 ng/mL) and deficient (≤19 ng/mL). Additional data collected included demographics, athletic performance, injury history and bone density. Results: 139/285 (48.8%) of athletes were Vit D insufficient, with an additional 50/285 (17.5%) being deficient (Table 2). For football players specifically (our largest cohort of athletes), 71/91 (78%) had a Vit D level below normal, with the average value falling at 24.5 ng/mL. For injury susceptibility, there was a 7% increase in injuries for those with a below normal Vit D. (40% vs 33%). For recovery length, athletes with a below normal Vit D took twice as long to recover (23.7 days vs 10.2 days). Conclusions: A large percentage collegiate athletes have insufficient or deficient levels of Vit D. Our results also suggest that a lower Vit. D level correlates to an increase in the number of musculoskeletal injuries sustained and an increase in recovery length. [Table: see text][Table: see text]
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Clements, Ronald H., Kishore Yellumahanthi, Mary Wesley, Naveen Ballem, and Kirby I. Bland. "Hyperparathyroidism and Vitamin D Deficiency after Laparoscopic Gastric Bypass." American Surgeon 74, no. 6 (June 2008): 469–75. http://dx.doi.org/10.1177/000313480807400603.

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Hyperparathyroidism (HPT) can occur after gastric bypass because of the alteration in vitamin D and calcium absorption. Adequate serum vitamin D concentrations have not been clearly defined in this patient population. Vitamin D (Vit D) and parathyroid hormone (PTH) were assessed 1 year after laparoscopic gastric bypass (LGB). The prevalence of HPT and Vit D deficiency were determined and their association was evaluated using Fisher's exact test. Ninety-three patients (aged 44 ± 1.1 years, 49.6 ± 0.67 kg/m2 body mass index, 79.6% female, 69.6% white) were evaluated. The prevalence of Vit D deficiency (less than 20 ng/mL) and HPT (greater than 65 pg/mL) was 23.6 per cent (n = 22) and 25.7 per cent (n = 28), respectively. Among patients with HPT, only eight of 28 (28.6%) had Vit D deficiency, and of those with Vit D deficiency, only eight of 22 (36.4%) had HPT. There was a weak inverse correlation (r = –0.37) between PTH and Vit D. Blacks are at higher risk for Vit D deficiency. There was no significant association between Vit D deficiency and HPT, Vit D deficiency and Roux limb length, or HPT and Roux limb length. After LGB, Vit D deficiency and hyperparathyroidism occur commonly. Body mass index and Roux limb length are not associated with these two conditions, but racial differences do exist. There is a weak inverse correlation between Vit D and PTH. Further research is needed to elucidate the causes, treatments, and significance of HPT after LGB.
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Elsamany, Shereef, Omaima Elemam, Ahmed Zeeneldin, Soha Elmorsy, Ahmed Khatry, Faisal Alhuthali, and Suha Alsayed. "Prognostic value of vitamin-D level in non-metastatic breast cancer patients in Saudi Arabia." Asian Pacific Journal of Cancer Care 1, no. 1 (February 3, 2020): 9–14. http://dx.doi.org/10.31557/apjcc.2020.1.1.9-14.

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Background Deficiency of vitamin-D (Vit-D) was associated with poor survival outcome in several studies across different tumour types. The present study aims to assess the prevalence and prognostic value of Vit-D deficiency among breast cancer patients in a single institution in Saudi Arabia. Methods In this retrospective study, we screened patients who presented with non-metastatic breast cancer to King Abdullah Medical City, Saudi Arabia from June 2011 to December 2015. We checked baseline Vit-D level before starting systemic therapy in addition to other clinicopathological factors. Low Vit-D was defined as Vit-D level less than 30 ng /ml. The relations of Vit-D level (taking the median as the cutoff) with clinicopathological factors were assessed using Chi-Square test. Differences in survival outcome were compared using log rank test. Results We screened 340 patients with non-metastatic breast cancer. Baseline Vit-D levels were available for 189 patients. The median age was 50 years (range: 26- 86 years). Noteworthy, 169 (89.4%) of patients had Vit-D level <30 ng/ml with a median of 14.9 ng/ml (range: 4.0 - 45.0). Low Vit-D level (below the median) was significantly more common in premenopausal (p=0.011) and ER-negative patients (p=0.011). However, lymphovascular invasion (p=0.001), clinically (p=0.023) and pathologically positive axillary LNs (p=0.041) were linked with higher Vit- D level. After a median follow up period of 58.2 months, 14 patients died and 40 relapsed. The 5-year disease-free survival (DFS) rates was 74.8%. The 5-year DFS rate in patients with higher Vit-D level above the median was 78.8% compared to 71.1% in patients with lower Vit-D level with no statistically significance difference (p= 0.22). The 5-year overall survival (OS) rate was 90.2%. Meanwhile, no difference in 5-year OS rate in patients with higher and lower Vit-D levels (90.3% and 89.7% respectively, p=0.6). Conclusion Low Vit-D level was prevalent among the studied breast cancer patients. Low Vit-D level was associated with ER-negative phenotype and premenopausal patients. Baseline Vit-D level was not significantly linked with survival outcome.
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Більше джерел

Дисертації з теми "Vit D"

1

Dolezal, Vit [Verfasser]. "Multifocus fluorescence correlation spectroscopy / Vit Dolezal." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2016. http://d-nb.info/1121535380/34.

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2

Corr?a, Ludmila Campo Dall'orto. "? margem do corpo d ?gua: a rela??o entre a ba?a e a cidade de Vit?ria (ES)." Pontif?cia Universidade Cat?lica de Campinas, 2014. http://tede.bibliotecadigital.puc-campinas.edu.br:8080/jspui/handle/tede/124.

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Made available in DSpace on 2016-04-04T18:22:08Z (GMT). No. of bitstreams: 1 Ludmila Campo Dallorto Correa.pdf: 3039624 bytes, checksum: 0aa4abbaa853d5b8fade1a006fc4227e (MD5) Previous issue date: 2014-02-20
This work has the physical reference the city of Vit?ria and want to make a contribution of relationships that the city has with the water bodies. In the case of the city of Vit?ria, analysis and reflection to bring water bodies that surround it: Ba?a de Vit?ria, the Canal da Passagem and the channel between the islands. These are the most significant bodies of water which make the outline of the city. The paper also proposes a reflection about the role of local governments on the changes promoted in spaces located on the banks of water bodies for the qualification and integration of the city with the bay and channels.
O presente trabalho tem como referencia fisica a cidade de vit?ria e pretende trazer uma contribui??o das rela??es que a cidade estabelece com os corpos d agua. No caso da cidade de Vit?ria, trazemos para analise e reflex?o os corpos d ?gua que a cercam: a Ba?a de Vit?ria, o Canal da Passagem e o canal entre ilhas. Trata-se dos corpos d agua mais significativos que fazem o contorno da cidade. O trabalho tamb?m prop?e uma reflex?o a cerca da atua??o das administra??es locais quanto ?s modifica??es promovidas em espa?os localizados nas margens dos corpos d ?gua para a qualifica??o e para a integra??o da cidade com a ba?a e com os canais.
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3

POSA, FRANCESCA. "Vitamin d and nanostructured surfaces in osteoblastic differentiation of dental stem cells." Doctoral thesis, Università di Foggia, 2017. http://hdl.handle.net/11369/361973.

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1α, 25-diidrossivitamina D3 (1,25(OH)2D3), il metabolita attivo della Vitamina D (Vit D), aumenta l'assorbimento intestinale di calcio e fosfato, mantenendo un corretto bilanciamento nel rimodellamento osseo. La Vit D ha un effetto anabolizzante sul sistema scheletrico ed è fondamentale nel promuovere il differenziamento osteoblastico di cellule staminali mesenchimali umane (hMSCs) isolate da midollo osseo. Al fine di superare alcuni aspetti negativi associati all'utilizzo di MSCs da midollo osseo quali morbilità, dolore e bassa resa di cellule, sono state studiate fonti alternative di tali cellule. Le MSCs possono essere isolate anche dal dente nella sua forma immatura, il germoglio dentale: le Cellule Staminali da Gemma Dentale (Dental Bud Stem Cells - DBSCs) sono cellule staminali adulte che possono effettivamente differenziare in senso osteoblastico. Lo scopo del progetto è quello di studiare l'effetto della Vit D sulle DBSCs, che rappresentano un modello utile per comprendere l'attività anabolica delle cellule ossee a partire da precursori osteoblastici molto indifferenziati. Dal momento che l'adesione delle MSCs alla Matrice Extra Cellulare (ECM) è ancora poco caratterizzata, così come il ruolo delle proteine della ECM nella regolazione del differenziamento osteogenico, abbiamo innanzitutto studiato il nostro modello cellulare di DBSCs per l'espressione di Integrine e Caderine così come per l'interazione con proteine della ECM. Abbiamo osservato che le DBSCs mostrano un modello di adesione molecolare paragonabile a quello descritto per le MSCs. Abbiamo dimostrato una differenziazione delle DBSCs in senso osteogenico con acquisizione di un fenotipo osteoblastico, incrementata dal trattamento con la Vit D. Abbiamo osservato che le DBSCs, trattate con 1,25(OH)2D3, esprimevano livelli più elevati dei principali marcatori osteoblastici e formavano noduli di matrice mineralizzata in vitro. Questi risultati riflettono l'origine mesenchimale delle DBSCs e confermano le loro caratteristiche osteoblastiche. Inoltre, al fine di chiarire l'effetto del microambiente sul comportamento delle DBSCs, abbiamo analizzato anche la distribuzione dell’integrina αVβ3 e la formazione di Adesioni Focali (FAs) in cellule seminate su superfici con diversi rivestimenti in presenza di Vit D. Abbiamo quindi osservato che la Vit D sembra indurre l’espressione di tali adesioni focali nel nostro modello cellulare. Le nostre osservazioni suggeriscono che la Vit D sia in grado di agire direttamente su queste cellule, che possono essere considerate dei precursori degli osteoblasti, indirizzandole verso una formazione ossea più elevata.
1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active metabolite of Vitamin D (Vit D), increases intestinal absorption of calcium and phosphate, maintaining a correct balance of bone remodeling. Vit D has an anabolic effect on the skeletal system and is key in promoting osteoblastic differentiation of human Mesenchymal Stem Cells (hMSCs) from bone marrow. In order to overcome some negative aspects connected with the use of MSCs from bone marrow, i.e. morbidity, pain and low yield of cells, other sources of MSCs have been examined. MSCs can be also isolated from the immature form of the tooth, the dental bud: Dental Bud Stem Cells (DBSCs) are adult stem cells that can effectively undergo osteoblastic differentiation. The aim of the project is to study the effect of Vit D on DBSCs, which represent a useful model to understand the anabolic activity of the bone cells, starting from very undifferentiated osteoblast precursors. Since MSCs adhesion to Extra Cellular Matrix (ECM) is still poorly characterized, as well as ECM proteins role in regulating osteogenic differentiation, we studied our cell model of DBSCs for the expression of Integrins and Cadherins as well as for ECM protein interaction. We demonstrated a functional osteogenic differentiation of DBSCs towards an osteoblastic phenotype, being incremented by the Vit D treatment. We observed that DBSCs treated with 1,25(OH)2D3, expressed increased levels of the main osteoblastic markers and formed mineralized matrix nodules in vitro. These results reflected the mesenchymal origin of DBSCs and confirmed their osteoblast-like features. Moreover, in order to elucidate the effect of the microenvironment on DBSCs behavior, we also analyzed αVβ3 integrin distribution and Focal Adhesion formation in cells seeded on surfaces with different coatings in the presence of Vit D. We observed that Vit D seems to induce the expression of focal adhesions in our cell model. Our observations suggest that Vit D acts directly on these cells, that can be considered osteoblast precursors, directing them to an increased bone formation.
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4

Vit, Katharina Allegra [Verfasser], and Wulf [Akademischer Betreuer] Blankenfeldt. "Structural and Functional Studies on beta-alpha-beta-beta-beta-Module Resistance Proteins from Pseudomonas aeruginosa PAO1 and Structural Insights into Mycobacterial Ergothioneine Biosynthesis / Katharina Allegra Vit ; Betreuer: Wulf Blankenfeldt." Braunschweig : Technische Universität Braunschweig, 2015. http://d-nb.info/1175818577/34.

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5

Pierron, Géraldine. "Les enjeux psychiques de la relation d'aide entre l'aidant familial et son proche atteint de maladie d'Alzheimer ou de maladies apparentées, lorsque le patient vit à domicile." Thesis, Besançon, 2015. http://www.theses.fr/2015BESA1013/document.

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Анотація:
Si la littérature fait état des réticences des aidants familiaux, à demander de l'aide, leurs ressortspsychiques restent mal connus. Pourtant le sentiment de culpabilité a déjà été repéré, comme un obstacle à lademande d'aide de l'aidant, mais ce facteur a été peu exploré dans un axe de recherche. Cette rechercherepose sur l'hypothèse que le sentiment de culpabilité de l'aidant familial, représenterait le principal frein,susceptible d'empêcher sa demande d'aide et de soutien, face à la maladie d'Alzheimer ou à la maladieapparentée de son proche, lorsque le patient vit à domicile. Une sous-hypothèse vise à situer différemment lesentiment de culpabilité de l'aidant familial, selon sa position de conjoint, ou plus largement de descendant(enfant, belle-fille, gendre...), dans la relation d'aide. Pour tester cette hypothèse trente huit entretiens semidirectifsont été réalisés, et complétés par la passation des échelles d'attachement (RSQ), du caregiver(CRA), et de dépression (Beck).Cette recherche vise à expliciter les fondements, et les mécanismes du sentiment de culpabilité des aidantsfamiliaux, en l'articulant à la problématique de perte, qui est coeur de la maladie d'Alzheimer ou desmaladies apparentées. Elle apporte donc un éclairage nouveau sur le travail psychique de l'aidant familial,qui s'écarte de son seul abord sous l'angle du fardeau et de l'épuisement, pour l'envisager à la lumière dutravail du pré-deuil, qui apparaît comme la clé de voûte de la relation d'aide. Par conséquent, la recherchesuivra le cycle de la dépendance du patient, pour dégager à chacun de ses stades, les incidences de la pertedans l'espace psychique et intersubjectif chez l'aidant familial, selon la nature des liens d'attachementdéveloppés avec le patient, mais aussi avec le groupe familial. A partir de là, nous tenterons de relier leregistre principal d'élaboration de la perte, à un profil d'aidant singulier dans la relation d'aide, afin d'éclairerles liens entre ses manifestations de culpabilité, et sa demande d'aide
If the litterature states reservations of the family caregivers, to ask for help, their psychic springsremain badly known. Nevertheless the sense of guilt was already located, as an obstacle at the request ofhelp, of the caregiver, but this factor was little explored in a research theme. This research bases on thehypothesis that the sense of guilt of the family caregiver, would represent the main brake, susceptible toprevent his request of help and support, in front of the Alzheimer's disease or the related disease, when thepatient lives at home. A sub-hypothesis aims at placing differently the sense of guilt of the familiy caregiver,according to its spouse's position, or more widely of descendant (child, son-in-law, daughter-in-law) in therelation of help. To test this hypothesis, thirty eight semi-directive conversations were realized andcompleted by the signing of the scales of attachment (RSQ), the caregiver (CRA), and depression (Beck).This research aims at clarifying foudations, and mechanisms of the sense of guilt of the family caregivers, byarticulating it in the problem of loss, which is heart of Alzheimer's disease or the related diseases. It thusgives a new perspective on the psychic work of the family caregiver, which deviates from its only accessunder the angle of the burden and the exhaustion, to envisage it in the light of the work of the pre-mourning,which appears at the keystone of the relation of help. Consequently, the research will follow the cycle of thedependence of the patient, to release in each of its stages, the incidences of the loss in the psychic andintersubjective space at the family caregiver, according to the nature of the links of attachment developpedwith the patient, but also with the family group. From there, we shall try to connect the main register ofelaboration of the loss, in a profile of singular caregiver in the relation of help, to light the links between hisdemonstrations of guilt and his demand of help
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CHEVANCE, ANDRE. "Psychopathologie de la vie quotidienne du sujet age. Alzheimer le mal de lethe." Paris 7, 1999. http://www.theses.fr/1999PA070047.

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A partir d'un regard sur la psychopathologie de la vie quotidienne du sujet age, l'auteur nous propose une approche psychodynamique originale de la maladie d'alzheimer. Les outils methodologiques dont il a use lui ont permis d'aborder ces trois modes d'analyse bien distincts que sont: la clinique, la psychanalyse et la neuropsychologie. Ces trois approches lui ont permis de developper une hypothese psychogene de la maladie d'alzheimer, tout en prenant en compte les etiologies proposees par les biologistes, les neurologues et les geneticiens. L'exhumation du mythe de lethe permet par sa lecture d'ouvrir cette maladie a une vision psychodynamique. En revelant des intentions inconscientes ce mythe permet de donner du sens a cette maladie que l'on nomme "maladie du siecle".
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Coeytaux, Emmanuel. "Utilisation d' un peptide du VIH-1 pour la vectorisation d' ADN." Paris 7, 2003. http://www.theses.fr/2003PA077146.

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8

Dratwicki, Alexandre. "Un nouveau commerce de la virtuosité : métamorphoses de la symphonie concertante au sein des institutions musicales parisiennes (1780-1830) /." Paris : [A. Dratwicki], 2003. http://catalogue.bnf.fr/ark:/12148/cb39093293k.

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9

Drouin, Christian. "Vitamin D analogues via dynamic combinatorial chemistry." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96890.

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Calcitriol (1alpha,25-(OH)2 D3, 1,25D) is known for its calcium regulatory function, but also for being a powerful inhibitor of cell growth in a variety of normal and neoplastic cells. As such, it is a lead structure in the development of new cancer drugs. The goal of our project is to identify analogues of calcitriol which bind tightly to the vitamin D receptor (VDR) yet do not exhibit unwanted hypercalcemic effects. The development of novel analogues using conventional chemistry and dynamic chemistry was investigated. First, the numerous building blocks required for the exploration of the different libraries were created through the use of conventional techniques. We then developed different synthetic schemes based primarily on thiol alkylation and amide couplings, enabling rapid parallel synthesis of potential 1,25D analogues. Preliminary investigations allowed us to implement with our collaborators a set of biological assays to evaluate our compounds. Although some analogues appeared to bind to the VDR, it was found that none of the 8 analogues tested in the preliminary studies seemed to be vitamin D receptor (VDR) agonists. In a second part, our research focused on the study of dynamic combinatorial chemistry as a tool for the synthesis of 1,25D analogues. Our first dynamically-generated libraries were created via thioester exchange. It was found that the rate of thioester exchange was dependent on the nature of the thiols involved and the acyl portion of the thioesters. Aliphatic acid thioesters exchanged more slowly than aromatic acid thioesters. The use of branched (alpha-substituted) thiols also slowed the rate compared to primary ones. However, the use of large concentration of aliphatic or aromatic thiols could accelerate the thioester exchange. When thioesters were placed in presence of protein targets in a dynamic system, their inherent electrophilic nature rendered them prone to chemical decomposition (hydrolysis and acylation of protein nucleophilic residues) at basic pHs. Nonetheless, we created thioester libraries of up to 40 members from as few as 7 building blocks under near neutral conditions. We showed that these dynamic libraries ere influenced by the presence of proteins. We have not been able to confirm if thioester libraries were influenced exclusively by the VDR via its binding site. Some of our observations challenged the viability of the thioester exchange as a reversible process in the context of VD3 analogue synthesis. Finally, we created dithiol building blocks, amenable to disulfide exchange in dynamic libraries. Chemically stable, these disulfide entities easily generated libraries of at least 30 members from as few as 7 building blocks. Our preliminary disulfide libraries seemed uninfluenced by VDR's presence. These results still allowed us to understand better the characteristics and limitations of dynamic systems applied to the development of novel vitamin D analogues.
Calcitriol (1alpha,25-dihydroxyvitamine D3, 1,25D) est connu pour sa fonction dans la régulation du métabolisme du calcium, mais aussi comme étant un puissant inhibiteur de la prolifération cellulaire dans un éventail de cellules normales et néoplastiques. Comme tel, il représente le point de départ pour le développement de nouvelles molécules anticancéreuses. Le but de notre projet est d'identifier des analogues du calcitriol capables de se lier au récepteur de la vitamine D (RVD) sans causer d'hypercalcémie. Le développement de nouveaux analogues de la vitamine D3 a été exploré en utilisant la chimie conventionelle et la chimie dynamique. Dans un premier temps, de nombreux synthons nécessaires à la création des différentes librairies ont été fabriqués par des techniques de synthèse traditionnelles. Ensuite, des routes de synthèse basées sur l'alkylation de thiols et la formation d'amides ont été élaborées, permettant une synthèse en parallèle efficace d'analogues de la vitamine D. En collaboration avec nos partenaires, des études préliminaires ont permis d'établir la validité d'une série de tests pour évaluer l'activité biologique de nos analogues sur le récepteur de la vitamine D. Bien que plusieurs composés semblent se lier au récepteur, aucun des 8 analogues évalués de façon préliminaire n'ont révélé une activité agoniste du RVD. Dans un deuxième temps, nous avons axé notre recherche sur l'étude de la chimie combinatoire dynamique (CCD) comme outil pour la création et l'évaluation d'analogues de la vitamine D. La CCD est basée sur le fait qu'une protéine peut influencer la composition de bibliothèques dynamiques en favorisant la création de ses propres ligands, et ce, proportionnellement à leur constante d'affinité. Les premières bibliothèques dynamiques furent créées à partir d'échanges entre thioesters. Il a été évalué qualitativement que la vitesse de ce processus est dépendante de la nature des thiols impliqués ainsi que de la nature de la portion acyl des thioesters. L'échange des thioesters d'acides aliphatiques est plus lent que celui des thioesters d'acides aromatiques. Aussi, plus les thiols sont encombrés stériquement, plus le processus est lent. Toutefois, l'utilisation de grandes concentrations de thiols aromatiques et aliphatiques peut accélérer le processus d'échange. Lorsque des thioesters sont utilisés en présence de protéines à pH basique, leur caractère électrophilique les rend propices à la dégradation chimique par hydrolyse ou par acylation des fonctionnalités nucléophiles des protéines. Néanmoins, à pH neutre, des bibliothèques de thioesters possédant plus de 40 composantes furent facilement réalisées à partir de seulement 7 synthons. Il a pu être démontré que la composition de ces bibliothèques est influencée par la présence de protéines. Cependant, nous n'avons pas été en mesure de confirmer si le RVD a véritablement influencé la nature des bibliothèques de thioesters grâce à son site de liaison. Certaines de nos observations mettent en doute l'utilisation de la transthioestérification comme processus dynamique viable pour la création d'analogues de la vitamine D en présence de protéines.Finalement, des synthons dithiols furent créés et leur combinaison a permis la formation de bibliothèques dynamiques de plus de 30 composés, grâce à l'échange de disulfures. Les études préliminaires ont montré que les bibliothèques de disulfures ne semblent pas être influencées par la présence du RDV. Ces résultats ont permis de connaître les caractéristiques et les limites de ces systèmes dynamiques appliqués au développement de nouveaux analogues de la vitamine D.
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KARAM, SOFIA BAPTISTA. "CORPS EN COMBAT, SCÈNES D UNE VIE." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2018. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=34268@1.

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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO
COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO
PROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTS. DE ENSINO
PROGRAMA DE DOUTORADO SANDUÍCHE NO EXTERIOR
En partant d un contexte familial d une maladie neurodégénérative héréditaire rare et incurable qui atteint le cervelet, provoquant la perte progressive de la coordination motrice et des forces musculaires, sans que les capacités intellectuelles ne soient affectées, un corps se jette dans un parcours d étude et d écriture, où la recherche théorique et une vie s entrelacent. La thèse se compose de registres d écriture variés, entremêlant des scènes, des fabulations, des souvenirs, des délires, des essais, et d autres voix d intercesseurs divers qui traversent le texte en dialogue avec le corps-pensée en combat et en construction tout au long de la recherche et de l écriture.
A partir de um quadro familiar de uma doença neurodegenerativa hereditária rara e incurável que ataca o cerebelo, de corpos que perdem progressivamente sua coordenação motora e sua força muscular, sem ter sua capacidade intelectual afetada, um corpo se lança em um caminho de estudo e escrita, onde pesquisa teórica e uma vida se entrelaçam. A tese se desenrola com registros de escrita variados, misturando cenas, fabulações, memórias, delírios, ensaios, e vozes de intercessores diversos que atravessam o texto em diálogo com o corpo-pensamento em combate e em construção ao longo do processo de pesquisa e escrita.
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Книги з теми "Vit D"

1

Khosravi, Mitra. La vie quotidienne du malade d'Alzheimer: Guide pratique. Paris: Doin, 1995.

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Khosravi, Mitra. La vie quotidienne du malade d'alzheimer: Guide pratique. 3rd ed. Paris: Groupe Liaison, 2006.

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Rimell, R. L. Fokker D. VII. Anthology 3. Berkhamsted: Albatros Publications, 2002.

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Ungaretti, Giuseppe. Vita d"un uomo 106 poesie. Milan: Arnoldo Mondadori Editore, 1991.

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5

Thegan, Chorepiscopus of Trier, approximately 800- and Astronomus active 814-840, eds. Vita Caroli Magni / Einhard. Vita Hludowici / Thegan. Anonymi Vita Hludowici Imperatoris / Astronomus: L - D. [Wien: Im Selbstverlag, 2012.

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Vermeulen, Michel. La vie mystique chrétienne: Selon D. Denys Houtepen. Salzburg, Austria: Institut für Anglistik und Amerikanistik, Universität Salzburg, 2001.

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La vie rêvée ou presque de Manon D. [Paris]: Casterman, 2012.

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8

Guttman, Jon. SPAD VII vs Albatros D III, 1917-18. Oxford, UK: Osprey Pub., 2011.

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9

Cuir, Raphaël. La vie mode d'[in]emploi: Exposition : transfuge. [Paris]: J.M. Place, 2000.

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Regard sur ma vie: Autobiographie. Beloeil, Québec: Éditions La Caboche, 2009.

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Частини книг з теми "Vit D"

1

Thornton, John K. "Vita, D. Beatriz Kimpa." In Encyclopedia of African Religions and Philosophy, 689–90. Dordrecht: Springer Netherlands, 2021. http://dx.doi.org/10.1007/978-94-024-2068-5_383.

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Hempel, B. "Toxikologie von D-Campher." In Phytopharmaka VI, 29–37. Heidelberg: Steinkopff, 2000. http://dx.doi.org/10.1007/978-3-642-57735-2_4.

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Thy, Hoang, A. M. Bagirov, and A. M. Rubinov. "Clustering via D. C. Optimization." In Nonconvex Optimization and Its Applications, 221–34. Boston, MA: Springer US, 2001. http://dx.doi.org/10.1007/978-1-4613-0279-7_11.

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Belz, G. G., K. Breithaupt-Grögler, R. Butzer, V. Herrmann, C. Malerczyk, C. Mang, and S. Roll. "Klinische Pharmakologie von D-Campher." In Phytopharmaka VI, 21–28. Heidelberg: Steinkopff, 2000. http://dx.doi.org/10.1007/978-3-642-57735-2_3.

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5

Lu, Shen Zhou, Lin Feng, Ming Zhong Li, Chuan Xia Di, and Lun Bai. "Study on Silk I Porous 3-D Scaffolds." In Advanced Biomaterials VII, 233–36. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.233.

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Van Rompay, Lucas. "A Precious Gift to Deir al-Surian (AD 1211): Ms. Vat. Syr. 13." In Malphono w-Rabo d-Malphone, edited by George Kiraz, 735–50. Piscataway, NJ, USA: Gorgias Press, 2008. http://dx.doi.org/10.31826/9781463214814-034.

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Hiller, W. J., St Koch, T. A. Kowalewski, P. Mitgau, and K. Range. "Visualization of 3-D Natural Convection." In Flow Visualization VI, 474–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-84824-7_82.

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Lee, Han Ul, Byung Kim, Seung Jae Lee, Geun Bae Lim, Sung Won Kim, Jong Won Rhie, and Dong Woo Cho. "Development of Micro-Patterned 2.5-D Scaffold Using Micro-End-Milling." In Advanced Biomaterials VII, 53–56. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.53.

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9

Lukierski, Jerzy, Pierre Minnaert, and Anatol Nowicki. "D = 4 Quantum Poincaré-Heisenberg Algebra." In Symmetries in Science VI, 469–75. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4899-1219-0_38.

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10

Amaya, K., and S. Aoki. "Optimum Design of Cathodic Protection System by 3-D BEM." In Boundary Element Technology VII, 375–88. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2872-8_26.

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Тези доповідей конференцій з теми "Vit D"

1

"Vitamin D3 Deficiency Among Females in Erbil City." In 4th International Conference on Biological & Health Sciences (CIC-BIOHS’2022). Cihan University, 2022. http://dx.doi.org/10.24086/biohs2022/paper.495.

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This study aimed to evaluate the percentage of Vitamin D deficiency in women’s in Erbil city, Kurdistan, Iraq by direct assessment and intervention, carried out in the department of nutrition and dietetics, at Cihan University, Erbil. The methods of work designed for females participants in different ages who visited health care centers and they were ready to take part in this study and filling the questionnaire, after they accepted and agree to participate then they have to do Vitamin D3 blood analysis test and depend on the result our team continue to contact with them and deliver brochures’ about Vit. D and follow up the cases one by one as much as possible especially those who had deficiency, our goal was to increase the awareness and they have to do second blood test to evaluate the progress and impact of the intervention. The main result of this study was, the percentage of deficiency more than (53%) of the participants, meanwhile many correlations was found between the health and nutritional situation and Vit. D deficiency. On the other hand, the intervention which was carried out to increase the awareness helped many females who had deficiency and accept to continue participating in the program, more than (83 %) of them they skipped the vit. D3 deficiency depend on the second blood test which was done after period between (6 - 8 weeks) only. So, we can conclude that, females in Erbil suffering from this nutrient deficiency because of many reasons, as one of the nutritional problems, and they need more and more efforts and programs to help them in their life to be in good health.
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2

Akdemir, Ayse. "The protective effects of Vit D on pancreatic islet cell in high fructose-low STZ induced diabetes." In European Microscopy Congress 2020. Royal Microscopical Society, 2021. http://dx.doi.org/10.22443/rms.emc2020.985.

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Pratico, Elizabeth R., Carl Wegner, Paul E. Marken, and John J. Marczewski. "First multi-channel VFT application - the Linden project." In IEEE PES T&D 2010. IEEE, 2010. http://dx.doi.org/10.1109/tdc.2010.5484379.

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Jamali, S., A. Kazemi, and H. Shateri. "Comparing series and shunt reactive power compensation via UPFC from distance relay point of view." In IEEE PES T&D 2010. IEEE, 2010. http://dx.doi.org/10.1109/tdc.2010.5484345.

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5

Koo, Ja-Il, Heesub Lee, and Yongmin Kim. "Applications of 2-D and 3-D compression algorithms to ultrasound images." In Medical Imaging VI, edited by Yongmin Kim. SPIE, 1992. http://dx.doi.org/10.1117/12.59521.

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6

Szmigiel, Marta A., Malwina Geniusz, and Maciej K. Geniusz. "Color vision tests comparison: Farnsworth D-15 versus Lanthony D-15." In Light in Nature VI, edited by Joseph A. Shaw, Katherine Creath, and Vasudevan Lakshminarayanan. SPIE, 2017. http://dx.doi.org/10.1117/12.2274486.

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7

Basu, Sumit, John Dunagan, Kevin Duh, and Kiran-Kumar Muniswamy-Reddy. "BLR-D." In Managing Large-scale Systems via the Analysis of System Logs and the Application of Machine Learning Techniques. New York, New York, USA: ACM Press, 2011. http://dx.doi.org/10.1145/2038633.2038635.

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8

Ho, C. Y. F. "Design of interpolative sigma delta modulators via a semi-infinite programming approach." In 5th IEE International Conference on ADDA 2005. Advanced A/D and D/A Conversion Techniques and their Applications. IEE, 2005. http://dx.doi.org/10.1049/cp:20050170.

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9

Al-Janabi, M. "Increasing the variability of centre frequency locations in multiple-band sigma-delta modulators via the use of fractional delay filters." In Third International Conference on Advanced A/D and D/A Conversion Techniques and their Applications. IEE, 1999. http://dx.doi.org/10.1049/cp:19990456.

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10

Gonc¸alves, Rodolfo T., Ce´sar M. Freire, Guilherme F. Rosetti, Guilherme R. Franzini, Andre´ L. C. Fujarra, and Julio R. Meneghini. "Experimental Comparisons to Assure the Similarity Between VIM (Vortex-Induced Motion) and VIV (Vortex-Induced Vibration) Phenomena." In ASME 2011 30th International Conference on Ocean, Offshore and Arctic Engineering. ASMEDC, 2011. http://dx.doi.org/10.1115/omae2011-49011.

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Vortex-Induced Motion (VIM) is another way to denominate the Vortex-Induced Vibration (VIV) in floating units. The main characteristics of VIM in such structures are the low aspect ratio (L/D < 4.0) and the unity mass ratio (m* = 1.0, i.e. structural mass equal water displacement). The VIM can occur in MPSO (Monocolumn Production, Storage and Offloading System) and spar platforms. These platforms can experience motion amplitudes of around their characteristic diameters. In such cases, the fatigue life of mooring and riser systems can be greatly reduced. Typically, the VIM model testing campaigns are carried out in the Reynolds range between 200,000 and 400,000. VIV model tests with low aspect ratio cylinders (L/D = 1.0, 1.7 and 2.0) and unity mass ratio (m* = 1.0) have been carried out at the Circulating Water Channel facility available at NDF/EPUSP. The Reynolds number range covered in the experiments was between 10,000 and 50,000. The characteristic motions (in the transverse and in-line direction) were obtained using the Hilbert-Huang Transform method (HHT) and then compared with results obtained in experiments found in the literature. The aim of this investigation is to definitely establish the similarity between the VIM and VIV phenomena, making possible to increase the understanding of both and, at same time, allowing some analytical models developed for VIV to be applied to the VIM scenario on spar and monocolumn platforms, logically under some adaption.
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Звіти організацій з теми "Vit D"

1

Hale, D. 3-D depth migration via McClellan transformations. Office of Scientific and Technical Information (OSTI), January 1990. http://dx.doi.org/10.2172/6369036.

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2

Schaper, Len. 3-D Cryo-Cooled Multi-Chip Modules via Optical Interconnects. Fort Belvoir, VA: Defense Technical Information Center, July 1999. http://dx.doi.org/10.21236/ada398387.

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Jørring, Adam, Andrew Lo, Tomas Philipson, Manita Singh, and Richard Thakor. Sharing R&D Risk in Healthcare via FDA Hedges. Cambridge, MA: National Bureau of Economic Research, April 2017. http://dx.doi.org/10.3386/w23344.

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Mineeva, Taisiya. Hadronization Studies via π0 Electroproduction off D, C, Fe, and Pb. Office of Scientific and Technical Information (OSTI), грудень 2013. http://dx.doi.org/10.2172/1432779.

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D., Muller, Epprecht M., and Sunderlin W.D. Nguoi nghèo o dâu? Cây coi o dâu?": Ðat muc tiêu xóa dói giam nghèo và bao ton rung tai Viet nam. Center for International Forestry Research (CIFOR), 2006. http://dx.doi.org/10.17528/cifor/002051.

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Kularatne, Dhanushka N., Subhrajit Bhattacharya, and M. Ani Hsieh. Computing Energy Optimal Paths in Time-Varying Flows. Drexel University, 2016. http://dx.doi.org/10.17918/d8b66v.

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Autonomous marine vehicles (AMVs) are typically deployed for long periods of time in the ocean to monitor different physical, chemical, and biological processes. Given their limited energy budgets, it makes sense to consider motion plans that leverage the dynamics of the surrounding flow field so as to minimize energy usage for these vehicles. In this paper, we present two graph search based methods to compute energy optimal paths for AMVs in two-dimensional (2-D) time-varying flows. The novelty of the proposed algorithms lies in a unique discrete graph representation of the 3-D configuration space spanned by the spatio-temporal coordinates. This enables a more efficient traversal through the search space, as opposed to a full search of the spatio-temporal configuration space. Furthermore, the proposed strategy results in solutions that are closer to the global optimal when compared to greedy searches through the spatial coordinates alone. We demonstrate the proposed algorithms by computing optimal energy paths around the Channel Islands in the Santa Barbara bay using time-varying flow field forecasts generated by the Regional Ocean Model System. We verify the accuracy of the computed paths by comparing them with paths computed via an optimal control formulation.
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Barash, Itamar, J. Mina Bissell, Alexander Faerman, and Moshe Shani. Modification of Milk Composition via Transgenesis: The Role of the Extracellular Matrix in Regulating Transgene Expression. United States Department of Agriculture, July 1995. http://dx.doi.org/10.32747/1995.7570558.bard.

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Altering milk composition via transgenesis depends on three main factors. (1) The availability of an efficient regulatory sequences for targeting transgene(s) to the mammary gland; (2) a reliable in vitro model to test the expression of transgenes prior to their introduction to the animal genome; and (3) better understanding of the major factors which determine the rate of gene expression and protein synthesis. The current studies provide the necessary means and knowledge to alter milk protein composition via transgenesis. The following specific goals were achieved: a: Identifying regulatory regions in the b-lactoglobulin (BLG) gene and the cross-talk between elements which enabled us to construct an efficient vector for the expression of desirable cDNA's in the mammary gland. b: The establishment of a sheep mammary cell line that serves as a model for the analysis of endogenous and exogenous milk protein synthesis in the mammary gland of livestock. c: An accurate comparison of the potency of the 5' regulatory sequences from the BLG and whey acidic protein (WAP) promoters in directing the expression of human serum albumin (HSA) to the mammary gland in vitro and in vivo. In this study we have also shown that sequences within the coding region may determine a specific pattern of expression for the transgene, distinct from that of the native milk protein genes. d: Characterizing the dominant role of ECM in transgene expression in mammary epithelial cells. e: Further characterization of the BCE-1 enhancer element in the promoter of the b-casein gene as a binding site for the c/EBP-b and Stat5. Identifying its interaction with chromatin and its up regulation by inhibitors of histone deacetylation. f: Identifying a mechanism of translational control as a mediator for the synergistic effect of insulin and prolactin on protein synthesis in the mammary gland.
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Neumann, Wiebke, Fredrik Stenbacka, Jonas Malmsten, Joris Cromsigt, Fredrik Widemo, Navinder Singh, and Göran Ericsson. GPS-märkt klövvilt i Nordmalings studieområde 2017-2021 – Fördelning, rörelse, livsmiljö och överlevnad. Sveriges lantbruksuniversitet, Institutionen för vilt, fisk och miljö, 2022. http://dx.doi.org/10.54612/a.67tect4oie.

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I Sverige är Nordmaling ett av få områden på så nordlig breddgrad där flera olika klövviltarter (d v s älg, rådjur, kronhjort och dovhjort, såväl som ren och mufflon) förekommer i större omfattning. Därmed utgör Nordmaling ett utmärkt referensområde att studera hur olika klövviltarter påverkar varandra och den omgivande miljön (studier om ekosystempåverkan) under nordiska förhållanden. Under perioden mars 2017 till mars 2021 märktes 27 vuxna älgkor, 23 rådjur (13 getter, 10 bockar) och 8 kronhindar med GPS-halsband. Totalt föddes 113 kalvar av 27 kor under studieperioden. Sommaröverlevnad av GPS-kornas årskalvar låg i genomsnitt på 88 % och efter jakten var 45% av de födda kalvarna vid liv. Antal kalvar som sköts under jakten skiftade mycket mellan åren och överlevnad under jakten låg i medel på 52%. Alla arter visade en dygnsrytm i sitt aktivitetsmönster med två aktivitetstoppar – en under tidig morgon och en senare på eftermiddag/kvälle. För älgkorna kunde vi se både vandringsälgar och stationära älgar. Rådjuren och kronhindarna visade inget tydligt vandringsbeteende som älgkorna – förutom ett rådjur. Livsmiljöanvändning under vinter varierade något mellan arterna där älgarna visade minst variation för olika livsmiljöer jämfört med tallskog och i relation till rådjur och kronhindar. Likaså under sommaren använde älgkorna ingen livsmiljö mer eller mindre än tallskog, medan rådjuren och kronhindarna visade en tydlig selektion för andra livsmiljöer än tallskog under vår/sommarperioden. Studier i Nordmalings området har ökat vår förståelse om hur älg, rådjur och kronhindar nyttjar ett borealt landskap på nordliga breddgrader. En viktig orsak till att försökspopulationen i Nordmaling fungerar så bra är det nära samarbetet med alla intresserade. Intresset är mycket stort, många olika användare är inne på hemsidan www.slu.se/alg-forskning.
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Feautrier, D., and D. L. Smith. Development and testing of a deuterium gas target assembly for neutron production via the H-2(d,n)He-3 reaction at a low-energy accelerator facility. Office of Scientific and Technical Information (OSTI), March 1992. http://dx.doi.org/10.2172/10171658.

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Carlos Torres-Verdin and Mrinal K. Sen. INTEGRATED APPROACH FOR THE PETROPHYSICAL INTERPRETATION OF POST-AND PRE-STACK 3-D SEISMIC DATA, WELL-LOG DATA, CORE DATA, GEOLOGICAL INFORMATION AND RESERVOIR PRODUCTION DATA VIA BAYESIAN STOCHASTIC INVERSION. Office of Scientific and Technical Information (OSTI), September 2004. http://dx.doi.org/10.2172/837074.

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