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Статті в журналах з теми "TRIM18"
Yap, Melvyn W., Mark P. Dodding, and Jonathan P. Stoye. "Trim-Cyclophilin A Fusion Proteins Can Restrict Human Immunodeficiency Virus Type 1 Infection at Two Distinct Phases in the Viral Life Cycle." Journal of Virology 80, no. 8 (April 15, 2006): 4061–67. http://dx.doi.org/10.1128/jvi.80.8.4061-4067.2006.
Повний текст джерелаToka, Felix N., Kiera Dunaway, Matylda Mielcarska, Felicia Smaltz, and Magdalena Bossowska-Nowicka. "Expression pattern of TRIM genes in bovine macrophages stimulated with PAMPs." Journal of Immunology 198, no. 1_Supplement (May 1, 2017): 129.7. http://dx.doi.org/10.4049/jimmunol.198.supp.129.7.
Повний текст джерелаSebastian, Sarah, Christian Grütter, Caterina Strambio de Castillia, Thomas Pertel, Silvia Olivari, Markus G. Grütter та Jeremy Luban. "An Invariant Surface Patch on the TRIM5α PRYSPRY Domain Is Required for Retroviral Restriction but Dispensable for Capsid Binding". Journal of Virology 83, № 7 (19 січня 2009): 3365–73. http://dx.doi.org/10.1128/jvi.00432-08.
Повний текст джерелаMargalit, Liad, Carmit Strauss, Ayellet Tal, and Sharon Schlesinger. "Trim24 and Trim33 Play a Role in Epigenetic Silencing of Retroviruses in Embryonic Stem Cells." Viruses 12, no. 9 (September 11, 2020): 1015. http://dx.doi.org/10.3390/v12091015.
Повний текст джерелаRybakowska, Paulina, Nina Wolska, Arkadiusz Klopocki, Kathy Sivils, Judith James, Harini Bagavant, and Umesh Deshmukh. "Multiple TRIM proteins are targets of autoimmune response in lupus and Sjogren's syndrome. (HUM7P.308)." Journal of Immunology 192, no. 1_Supplement (May 1, 2014): 184.17. http://dx.doi.org/10.4049/jimmunol.192.supp.184.17.
Повний текст джерелаAgarwal, Neeraj, Sebastien Rinaldetti, Bassem B. Cheikh, Qiong Zhou, Evan P. Hass, Robert T. Jones, Molishree Joshi, et al. "TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer." Proceedings of the National Academy of Sciences 118, no. 38 (September 13, 2021): e2102423118. http://dx.doi.org/10.1073/pnas.2102423118.
Повний текст джерелаStevens, Rebecca V., Diego Esposito, and Katrin Rittinger. "Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity." Life Science Alliance 2, no. 3 (April 26, 2019): e201900295. http://dx.doi.org/10.26508/lsa.201900295.
Повний текст джерелаZanchetta, Melania E., Luisa M. R. Napolitano, Danilo Maddalo, and Germana Meroni. "The E3 ubiquitin ligase MID1/TRIM18 promotes atypical ubiquitination of the BRCA2-associated factor 35, BRAF35." Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864, no. 10 (October 2017): 1844–54. http://dx.doi.org/10.1016/j.bbamcr.2017.07.014.
Повний текст джерелаMcAvera, Roisin M., and Lisa J. Crawford. "TIF1 Proteins in Genome Stability and Cancer." Cancers 12, no. 8 (July 28, 2020): 2094. http://dx.doi.org/10.3390/cancers12082094.
Повний текст джерелаHerquel, B., K. Ouararhni, K. Khetchoumian, M. Ignat, M. Teletin, M. Mark, G. Bechade, et al. "Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma." Proceedings of the National Academy of Sciences 108, no. 20 (April 29, 2011): 8212–17. http://dx.doi.org/10.1073/pnas.1101544108.
Повний текст джерелаДисертації з теми "TRIM18"
Basu, Shrivastava Meenakshi. "Régulation de la stabilité de NFATc3 par SUMO et les E3 ubiquitine-ligases Trim39 et Trim17." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT043.
Повний текст джерелаNFAT (Nuclear factor of activated T cells) transcription factors play important physiological roles in the development and function of many organs, notably in the immune system and nervous system. As a consequence, their dysregulation has been implicated in various human diseases such as cancer, neurodegenerative diseases, and auto-immune diseases. The regulation of NFAT activity by calcium-dependent nuclear-cytoplasmic shuttling has been extensively studied. In contrast, the regulation of NFAT protein level by the ubiquitin-proteasome system is still poorly understood. However, NFATs are short-lived proteins and regulation of their stability is critical for controlling their activity.In a previous study, my group has shown that the E3 ubiquitin-ligase Trim17 binds NFATc3 but does not promote its ubiquitination and rather stabilizes it. Preliminary results suggested that Trim39, a partner of Trim17, might be an E3 ubiquitin-ligase for NFATc3 and that SUMOylation of NFATc3 might modulate its stability. Therefore, the goal of my PhD was to understand the mechanisms through which Trim39, Trim17, and SUMO regulate the stability of NFATc3.During my PhD, I have characterized Trim39 as an E3 ubiquitin-ligase of NFATc3. Indeed, my results indicate that overexpression of Trim39, but not its inactive mutant, induces the ubiquitination of NFATc3 in cells. In contrast, silencing of endogenous Trim39 decreases the ubiquitination level of NFATc3. Recombinant Trim39 directly induces the ubiquitination of NFATc3 in vitro. Moreover, overexpression of Trim39 decreases the protein levels of NFATc3 whereas the silencing of Trim39 increases it. I have also shown that Trim17, which can bind Trim39, inhibits Trim39-mediated ubiquitination of NFATc3, both in cells and in vitro. Trim17 acts by both reducing the intrinsic E3 ubiquitin-ligase activity of Trim39 and by preventing the interaction between NFATc3 and Trim39. Furthermore, I found that a SUMOylation-deficient mutant of NFATc3 is less ubiquitinated and more stable than the wild type NFATc3, suggesting that SUMOylation of NFATc3 is important for its ubiquitination and degradation. Importantly, I identified one SUMO interacting motif (SIM) in the sequence of Trim39 through which Trim39 binds SUMO2 polymers via one of these SIMs. Mutation of this SIM in Trim39 or SUMOylation consensus sites in NFATc3 decreased the interaction between Trim39 and NFATc3, and the ubiquitination of NFATc3 mediated by Trim39. These results strongly suggest that Trim39 binds and ubiquitinates preferentially the SUMOylated forms of NFATc3 and therefore acts as a SUMO-targeted E3 ubiquitin-ligase (STUbL) for NFATc3. Finally, we have measured the impact of these mechanisms on the physiological function of NFATc3. I first found that Trim39 decreases the transcriptional activity of NFATc3. Furthermore, using primary cultures of cerebellar granule neurons as a model, we have shown that the mutation of the SUMOylation sites of NFATc3 and silencing of endogenous Trim39 enhances neuronal apoptosis, probably by stabilizing the NFATc3 protein. Taken together, these data indicate that Trim39 modulates neuronal apoptosis by acting as a STUbL for NFATc3 and by controlling its stability
Buberl, Cilli Dana [Verfasser]. "Expressionsanalyse der putativen E3 Ligasen Trim23 und Trim7 in der frühen Neuralentwicklung von Xenopus laevis / Cilli Dana Buberl." Halle, 2017. http://d-nb.info/1137867698/34.
Повний текст джерелаBorle, Pawar Ankush [Verfasser], Norbert [Akademischer Betreuer] Frey, and Dennis [Gutachter] Schade. "Functional characterization of TRIM24 and TRIM32 proteins in the heart through their interaction with Dysbindin / Ankush Borle Pawar ; Gutachter: Dennis Schade ; Betreuer: Norbert Frey." Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/1220691259/34.
Повний текст джерелаLocke, Matthew. "TRIM32 in Genetic Disease." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.514962.
Повний текст джерелаVENUTO, SANTINA. "Dissecting the TRIM8 role in the pathogenesis of glioma." Doctoral thesis, Università degli Studi di Foggia, 2019. http://hdl.handle.net/11369/382357.
Повний текст джерелаHuman gliomas are a heterogeneous group of primary malignant brain tumors, whose molecular pathogenesis is not yet solved. Therefore, understanding the molecular mechanisms underlying their aggressive behavior may lead to better management, appropriate therapies, and good outcomes through the identification of novel specific glioma-associated genes. Members of the tripartite motif (TRIM) proteins family are involved in many biological processes, including transcriptional regulation, cell proliferation and differentiation and cell cycle progression. Alterations of TRIM proteins are associated with a variety of pathologies like developmental disorders, inflammatory diseases and cancers. Among TRIMs protein family, TRIM8 encodes an E3 ubiquitin ligase involved in various pathological processes, including hypertrophy, antiviral defense, encephalopathy, and cancer development. We have identified TRIM8 as a gene aberrantly expressed in gliomas, whose expression correlates with unfavorable clinical outcome in glioma patients. To gain insights into the TRIM8 functions, we profiled the TRIM8 transcriptome and interactome in primary mouse embryonic neural stem cells using RNA-sequencing and proteomics, followed by bioinformatics analysis. Functional analysis, including biochemical and cellular assays were then performed to explore TRIM8 roles in different pathways. Our study firstly identified enriched pathways related to the neurotransmission and to the central nervous system (CNS) functions, providing additional evidence about the existence of a functional interactive crosstalk between TRIM8 and STAT3 with possible implications in the development and progression of glioma. Then, we found that TRIM8 interacts with KIFC1 and KIF11/Eg5, two master regulators of mitotic spindle assembly and cytoskeleton reorganization. Exploring the TRIM8 role in the mitotic spindle machinery, we showed that TRIM8 localizes at the mitotic spindle during mitosis and plays a role in centrosome separation at the beginning of mitosis with a subsequent delay of the mitotic progression and impact on chromosomal stability. Our results substantiate the role of TRIM8 in the brain functions through the deregulation of genes involved in different CNS-related pathways, including JAK-STAT. Moreover, we provided insights on the physiological function of TRIM8 in the mitotic spindle machinery, pointing to an emerging role for TRIM8 in the regulation of mitosis
Crichton, Jennifer E. "The Role of the E3-ubiquitin Ligase Trim17 in the Mitochondrial Cell Death Pathway." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23715.
Повний текст джерелаSimpson, Shmona. "Genetic, structural, and functional exploration of the restrictive capacity of TRIM proteins against immunodeficiency viruses." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:1af588ba-603a-4f39-9443-bb1a95d983f5.
Повний текст джерелаGuimarães, Dimitrius Santiago Passos Simões Fróes. "Caracterização bioquímica e celular da proteína TRIM49." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17131/tde-10042018-112409/.
Повний текст джерелаAutophagy is the process of degradation of intracellular proteins through their directioning to the lysosome. TRIM proteins can directely recognize autophagic cargo and also act as a hub for the phagophore nucleation complex, however the function of each domain and the role of the E3 ligase activity in this process is unknown. The TRIM49 protein cloned and expressed in E. coli or in human cells HEK23T showed no ubiquitin E3 ligase activity in vitro and cells transfected with the wild type protein showed lower levels of polyubiquitinated proteins, indicating that TRIM49 is not a bona fide E3 ubiquitin ligase. Cells challenged with Htt74Q presented lower cytotoxicity levels when cotransfected with wild type TRIM49, when compared with the RING domain mutant or with the truncated protein lacking the SPRY domain, indicating that both domains are required for its cellular activity. The wild type protein colocalizes with the autophagic marker LC3 after treatment with the autophagy inhibitor bafilomycin A1. Taken together, these results indicate that the TRIM49 protein plays a role in protein degradation independently of a E3 ligase activity.
Bartsch, Frederike [Verfasser], and Elke [Akademischer Betreuer] Cario. "Funktion und Regulation von TRIM58 in der myeloischen Immunabwehr / Frederike Bartsch ; Betreuer: Elke Cario." Duisburg, 2019. http://d-nb.info/1196008418/34.
Повний текст джерелаMcGuire, Cy Christopher. "Evaluation of PGR properties of TRIMAX in cotton." Texas A&M University, 2005. http://hdl.handle.net/1969.1/2605.
Повний текст джерелаКниги з теми "TRIM18"
Sodums, Dzintars. Jauni trimdā. Rīgā: "Karogs", 1997.
Знайти повний текст джерелаOdom, Joe. TRIMIX diver manual. 3rd ed. Topsham, Me.]: Technical Diving International, 1998.
Знайти повний текст джерелаRibbons & trims. New York: Potter Craft, 2007.
Знайти повний текст джерелаProfessor Trim's becoming slimmer. St. Leonards, N.S.W: Allen & Unwin, 2003.
Знайти повний текст джерелаKont͡s︡ert za trima. Sofii͡a︡: Profizdat, 1986.
Знайти повний текст джерелаHennessy, Mark. Trim. Dublin: Royal Irish Academy, 2003.
Знайти повний текст джерелаDavid, Cameron-Smith, ed. Professor Trim's ultimate food energy guide. St. Leonards, N.S.W: Allen & Unwin, 2003.
Знайти повний текст джерелаRožkalne, Anita. Palma vējā: Literatūrvēsturiskas piezīmes par latviešu trimdu. Rīgā: Pētergailis, 1998.
Знайти повний текст джерелаMusta, Agim. Kampet e internimit dhe trimat e dëshpërimit. Tiranë: Shtëpia Botuese "Marin Barleti", 2012.
Знайти повний текст джерелаCain, Daniel. Un trimis al majestății sale, Nicolae Mișu. București: Editura Anima, 2007.
Знайти повний текст джерелаЧастини книг з теми "TRIM18"
Gooch, Jan W. "Trimer." In Encyclopedic Dictionary of Polymers, 767. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_12131.
Повний текст джерелаMoss, Joel, and Martha Vaughan. "ARD1/TRIM23." In Encyclopedia of Signaling Molecules, 406–11. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_644.
Повний текст джерелаMoss, Joel, Michaela U. Gack, and Martha Vaughan. "ARD1/TRIM23." In Encyclopedia of Signaling Molecules, 1–8. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4614-6438-9_644-1.
Повний текст джерелаBiswas-Fiss, Esther E., Stephanie Affet, Malissa Ha, Takaya Satoh, Joe B. Blumer, Stephen M. Lanier, Ana Kasirer-Friede, et al. "ARD1/TRIM23." In Encyclopedia of Signaling Molecules, 146–50. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_644.
Повний текст джерелаTempleton, J. L. "Tungsten Trimer Synthesis." In Inorganic Reactions and Methods, 80–81. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470145296.ch64.
Повний текст джерелаHirota, E., K. Kuchitsu, T. Steimle, J. Vogt, and N. Vogt. "39 C3H6F6 Difluoromethane trimer." In Molecules Containing Three or Four Carbon Atoms and Molecules Containing Five or More Carbon Atoms, 69. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-41504-3_40.
Повний текст джерелаDemaison, J. "143 H6O3 Water trimer." In Symmetric Top Molecules, 271–74. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-47532-3_145.
Повний текст джерелаSeong, Hongje, Seoung Wug Oh, Brian Price, Euntai Kim, and Joon-Young Lee. "One-Trimap Video Matting." In Lecture Notes in Computer Science, 430–48. Cham: Springer Nature Switzerland, 2022. http://dx.doi.org/10.1007/978-3-031-19818-2_25.
Повний текст джерелаDemaison, J. "323 C3H6F6 Difluoromethane trimer." In Asymmetric Top Molecules. Part 2, 134. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-10400-8_71.
Повний текст джерелаGooch, Jan W. "Trim." In Encyclopedic Dictionary of Polymers, 767. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_12130.
Повний текст джерелаТези доповідей конференцій з теми "TRIM18"
Duan, Wenyang, Hongsen Zhang, Limin Huang, Jianyu Liu, Wenbo Shao, Guanzhou Cao, and Zhang Shi. "Numerical Simulation of Trim Optimization on Resistance Performance Based on CFD Method." In ASME 2019 38th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/omae2019-96181.
Повний текст джерелаMetzler, M., IJ Diets, J. Hoyer, J. Wegert, N. Graf, C. Vokuhl, M. Gessler, RP Kuiper, and MCJ Jongmans. "TRIM28 haploinsufficiency predisposes to Wilms tumor." In 32. Jahrestagung der Kind-Philipp-Stiftung für pädiatrisch onkologische Forschung. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1687131.
Повний текст джерелаFong, Ka-Wing, Jonathan Zhao, Bin Zheng, and Jindan Yu. "Abstract 1521: Role of Trim28 in prostate cancer." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1521.
Повний текст джерелаKirkby, David R., and David T. Delpy. "An optoelectronic cross-correlator using a gain modulated avalanche photodiode for measurement of the tissue temporal point spread function." In Advances in Optical Imaging and Photon Migration. Washington, D.C.: Optica Publishing Group, 1996. http://dx.doi.org/10.1364/aoipm.1996.trit108.
Повний текст джерелаZhang, Changming, Mukherjee Subhas, Tucker-Burden Carol, Monica Chau, Jun Kong, and Daniel Brat. "Abstract 2516: TRIM8 modulates stem-like cells in glioblastoma." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-2516.
Повний текст джерелаFel'dman, Edward, and Elena I. Kuznetsova. "Quantum entanglement in trimer clusters." In The International Conference on Micro- and Nano-Electronics 2018, edited by Vladimir F. Lukichev and Konstantin V. Rudenko. SPIE, 2019. http://dx.doi.org/10.1117/12.2520034.
Повний текст джерелаPålsson, Lars-Olof, Vidmantas Gulbinas, Tomas Gillbro, Andrei V. Sharkov, Axel Parbel, and Hugo Scheer. "Excited state dynamics of PEC trimer." In The 54th international meeting of physical chemistry: Fast elementary processes in chemical and biological systems. AIP, 1996. http://dx.doi.org/10.1063/1.50200.
Повний текст джерелаHEŘMAN, PAVEL, and IVAN BARVÍK. "ENERGY RELAXATION AND TRANSFER IN TRIMER." In Proceedings of 2000 International Conference. WORLD SCIENTIFIC, 2001. http://dx.doi.org/10.1142/9789812811387_0049.
Повний текст джерелаGupta, Vikas, and Shanmuganathan Raman. "Automatic trimap generation for image matting." In 2016 International Conference on Signal and Information Processing (IConSIP). IEEE, 2016. http://dx.doi.org/10.1109/iconsip.2016.7857477.
Повний текст джерелаBarclay, A., Nasser Moazzen-Ahmadi, Bob McKellar, and Koorosh Esteki. "INFRARED SPECTRA OF C2H4 DIMER AND TRIMER." In 73rd International Symposium on Molecular Spectroscopy. Urbana, Illinois: University of Illinois at Urbana-Champaign, 2018. http://dx.doi.org/10.15278/isms.2018.te04.
Повний текст джерелаЗвіти організацій з теми "TRIM18"
Strathman, James. Extraboard Management: TriMet Case Study. Portland State University Library, February 2012. http://dx.doi.org/10.15760/trec.4.
Повний текст джерелаKalberer, Jennifer L., and Jennifer C. Spanich. Evaluation of the TRIMAX 280 System. Fort Belvoir, VA: Defense Technical Information Center, June 2002. http://dx.doi.org/10.21236/ada405546.
Повний текст джерелаTrumble, E. F. TRIMPWR: A post processor for TRIMHX. Office of Scientific and Technical Information (OSTI), November 1989. http://dx.doi.org/10.2172/6975898.
Повний текст джерелаTrumble, E. F. Validation and verification summary report for GRIMHX and TRIMHX. Office of Scientific and Technical Information (OSTI), December 1990. http://dx.doi.org/10.2172/10156331.
Повний текст джерелаTrumble, E. F. Validation and verification summary report for GRIMHX and TRIMHX. Office of Scientific and Technical Information (OSTI), December 1990. http://dx.doi.org/10.2172/5038892.
Повний текст джерелаFries, Joseph. Helicopter Trim Analysis. Fort Belvoir, VA: Defense Technical Information Center, June 1996. http://dx.doi.org/10.21236/ada310293.
Повний текст джерелаBrooks, Stephen. Integrated Fields of Permanent Magnet Dipole Trims. Office of Scientific and Technical Information (OSTI), October 2021. http://dx.doi.org/10.2172/1895098.
Повний текст джерелаMinden, M. L., and T. R. O'Meara. Range-Doppler, Target-Referencing Imaging Systems (RD-TRIMS). Fort Belvoir, VA: Defense Technical Information Center, January 1990. http://dx.doi.org/10.21236/ada360123.
Повний текст джерелаStrathman, James, Joseph Broach, and Steve Callas. Evaluation of Short Duration Unscheduled Absences Among Transit Operators: TriMet Case Study. Portland State University Library, September 2009. http://dx.doi.org/10.15760/trec.141.
Повний текст джерелаMills, John R. An Introduction To PC-TRIM. Portland, OR: U.S. Department of Agriculture, Forest Service, Pacific Northwest Research Station, 1989. http://dx.doi.org/10.2737/pnw-rn-491.
Повний текст джерела