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Добірка наукової літератури з теми "Thiols"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 12 жовтня 2024

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Статті в журналах з теми "Thiols"

Zelli, Renaud, Pascal Dumy, and Alberto Marra. "Metal-free synthesis of imino-disaccharides and calix-iminosugars by photoinduced radical thiol–ene coupling (TEC)." Organic & Biomolecular Chemistry 18, no. 13 (2020): 2392–97. http://dx.doi.org/10.1039/d0ob00198h.

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Deprotected iminosugar alkenes were subjected to thiol–ene coupling with deprotected sugar thiols to afford new imino-disaccharides. Two thiol–ene couplings converted these alkenes into iminosugar thiols and then multivalent iminosugars.

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YILMAZ, Yücel, Şaban KELEŞOĞLU, Kemal TEKİN, Bekir ÇALAPKORUR, Özcan EREL, Salim NEŞELİOĞLU, and Deniz ELCİK. "A New Biomarker in The Distinction Between Stable Coronary Artery Disease and Acute Coronary Syndrome:Thiols." Journal of Contemporary Medicine 12, no. 4 (June 1, 2022): 1–6. http://dx.doi.org/10.16899/jcm.981853.

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Backraund; Thiols are important elements for oxidation reactions and under oxidative stress. The aim of this study was to determine thiole levels, an antioxidative marker in CAD patients with stable and acute coronary syndrome. Methods; 210 of the patients included in the study were diagnosed with acute coronary syndrome (ACS), 205 consisted of patients with stable angina pectoris (SAP). Thiol groups levels and thiol/disulphide homeostasis was measured by spectrophotometrically. Results: Native thiol and total thiol levels, disulfide/natural thiol and disulfide/total thiol ratios were decreased in the ACS groups compared to the SAP groups Conclusions: Thiol levels and thiol / disulfide ratios can be used as markers to evaluate acute coronary syndrome.

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Kalyanaraman, B. "Thiyl radicals in biological systems: significant or trivial?" Biochemical Society Symposia 61 (November 1, 1995): 55–63. http://dx.doi.org/10.1042/bss0610055.

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Thiyl radicals are formed from one-electron oxidation of thiols. Thiyl radicals participate in a number of reactions including electron transfer, hydrogen abstraction and addition reactions with several biological constituents and xenobiotics. Thiyl radicals can be detected by optical spectroscopy or by electron spin resonance (ESR) spectroscopy. Thiyl radicals appear to play a role in the nitrosylation of thiols and protein thiols. The exact mechanism of thiol-induced enhancement of oxidative modification of low-density lipoprotein remains questionable. The proposed role of thiyl radicals in lipid peroxidation needs to be re-examined. It has been proposed that thiyl radicals are detoxified by superoxide dismutase in mammalian cells and by a thiol-specific enzyme in bacterial systems. We propose that thiols or protein thiols act as potent antioxidants in radical-induced damage via formation of thiyl radicals.

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Skalska, Jolanta, Paul S. Brookes, S. M. Nadtochy, Shannon Hilchey, Craig T. Jordan, Monica L. Guzman, Sanjay Maggirwar, Margaret M. Briehl, and Steven H. Bernstein. "Modulation of Cell Surface Protein Free Thiols; A Potential Novel Mechanism of Action of the Sesquiterpene Lactone Parthenolide in Non-Hodgkin's Lymphoma." Blood 114, no. 22 (November 20, 2009): 3774. http://dx.doi.org/10.1182/blood.v114.22.3774.3774.

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Abstract Abstract 3774 Poster Board III-710 Recent data supports the concept that redox regulation of cell surface protein thiols (i.e., exofacial thiols) effects critical cellular functions. We therefore hypothesized that redox-active anti-cancer therapeutics would modulate exofacial thiols, and that such modulation could be related to cell death mechanisms. To test this hypothesis, we used the sesquiterpene lactone parthenolide, a known anti-cancer agent. Parthenolide treatment results in a dose dependent decrease in mantle cell (MCL) and diffuse large cell lymphoma cell viability. Indeed, parthenolide decreases the level of free (ie. reduced) exofacial thiols on Granta MCL cells as assessed by flow cytometry. Parthenolide specifically modifies free thiols of surface proteins having molecular weights of ∼12 kd and ∼22 kd, as determined using a biotinylated thiol reactive reagent N-(biotinoyl)-N-(iodoacetyl) ethylendiamine (BIAM), which binds to free thiol groups and is detected by streptavidin-peroxidase staining of western blots. We further show that the central redox regulator thioredoxin is one of the surface protein thiol targets modified by parthenolide; specifically; (a) thioredoxin is detected on the Granta cell surface; (b) parthenolide directly interacts with free thiol groups on purified human thioredoxin, and; (c) parthenolide directly modifies Granta membrane associated thioredoxin, as determined with BIAM and neutravidin pull-down. To examine the functional consequences of parthenolide induced surface protein thiol modification, Granta cells were pretreated with the cell impermeable thiol antioxidant glutathione (GSH). Pretreatment with GSH inhibits the parthenolide induced; (a) decrease in exofacial free thiols; (b) modification of surface thioredoxin and; (c) Granta cell death. Pretreatment of Granta cells with GSH also inhibits parthenolide-mediated activation of JNK and inhibition of NFkB, two activities previously associated with the drug's anti-cancer activity. Based on these data, we postulate that at least one component of parthenolide's anti-lymphoma activity derives from its ability to modify the redox state of critical exofacial thiols. Indeed, to our knowledge, our data is the first to suggest that cancer cell exofacial thiols may be novel and important targets for cancer therapy. Supported by an NCI SPORE grant in lymphoma 1P50 CA130805. Disclosures: Bernstein: millenium: Consultancy; genentech: Consultancy, Speakers Bureau; enzon: Consultancy.

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Sawada, K., B. C. W. Hummel, and P. G. Walfish. "Intermediate Mr cytosolic components potentiate hepatic 5′-deiodinase activation by thiols." Biochemical Journal 238, no. 3 (September 15, 1986): 787–91. http://dx.doi.org/10.1042/bj2380787.

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The role in the activation of microsomal 5′-deiodinase (5′-DI) of rat hepatic cytosolic components of Mr approx. 13,000 (Fraction B) was studied in the presence of various concentrations of thiol compounds such as dithiothreitol (DTT), dihydrolipoamide (DHLA), GSH, and 2-mercaptoethanol (2-ME). Although Fraction B (which was prepared by gel filtration to exclude GSH and GSSG) had no intrinsic 5′-DI activity, could not stimulate microsomal 5′-DI activity in the absence of added thiol and did not contain GSH as a mixed disulphide, it could produce a 3-fold increase in the maximal deiodinase activity achievable with DTT as well as other thiols, with the order being the same as the activation potency of these thiols in the absence of Fraction B (i.e. DHLA greater than DTT greater than 2-ME greater than GSH). These observations suggest that: a component of cytosolic Fraction B, designated ‘deiodination factor B’ (DFB), operates as an efficient intermediary to enhance activation of microsomal 5′-DI by thiols through a mechanism independent of GSH; thiols may participate in a non-specific thiol-disulphide exchange with inactive (oxidized) DFB to convert it into an active form that contains one or more thiol groups and is more effective than GSH or other thiols in facilitating the re-activation of inactive (oxidized) microsomal 5′-DI thiol (ESI) to its active state (ESH).

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MANDAL, G., S. WYLLIE, N. SINGH, S. SUNDAR, A. H. FAIRLAMB, and M. CHATTERJEE. "Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimony." Parasitology 134, no. 12 (July 5, 2007): 1679–87. http://dx.doi.org/10.1017/s0031182007003150.

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SUMMARYThe current trend of antimony (Sb) unresponsiveness in the Indian subcontinent is a major impediment to effective chemotherapy of visceral leishmaniasis (VL). Although contributory mechanisms studied in laboratory-raised Sb-R parasites include an up-regulation of drug efflux pumps and increased thiols, their role in clinical isolates is not yet substantiated. Accordingly, our objectives were to study the contributory role of thiols in the generation of Sb unresponsiveness in clinical isolates. Promastigotes were isolated from VL patients who were either Sb responsive (n=2) or unresponsive (n=3). Levels of thiols as measured by HPLC and flow cytometry showed higher basal levels of thiols and a faster rate of thiol regeneration in Sb unresponsive strains as compared with sensitive strains. The effects of antimony on generation of reactive oxygen species (ROS) in normal and thiol-depleted conditions as also their H2O2 scavenging activity indicated that in unresponsive parasites, Sb-mediated ROS generation was curtailed, which could be reversed by depletion of thiols and was accompanied by a higher H2O2 scavenging activity. Higher levels of thiols in Sb-unresponsive field isolates from patients with VL protect parasites from Sb-mediated oxidative stress, thereby contributing to the antimony resistance phenotype.

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Folikumah, Makafui Y., Marc Behl, and Andreas Lendlein. "Reaction behaviour of peptide-based single thiol-thioesters exchange reaction substrate in the presence of externally added thiols." MRS Communications 11, no. 4 (July 14, 2021): 402–10. http://dx.doi.org/10.1557/s43579-021-00041-z.

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Abstract Identification of patterns in chemical reaction pathways aids in the effective design of molecules for specific applications. Here, we report on model reactions with a water-soluble single thiol-thioester exchange (TTE) reaction substrate, which was designed taking in view biological and medical applications. This substrate consists of the thio-depsipeptide, Ac-Pro-Leu-Gly-SLeu-Leu-Gly-NEtSH (TDP) and does not yield foul-smelling thiol exchange products when compared with aromatic thiol containing single TTE substrates. TDP generates an α,ω-dithiol crosslinker in situ in a ‘pseudo intramolecular’ TTE. Competitive intermolecular TTE of TDP with externally added “basic” thiols increased the crosslinker concentration whilst “acidic” thiols decreased its concentration. TDP could potentially enable in situ bioconjugation and crosslinking applications. Graphic abstract The competition between ‘pseudo intramolecular’ and intermolecular exchange of a peptide-based thiol-thioester exchange (TTE) substrate can be used to control the relative amount of final exchange products based on size and pKa values of externally added thiols. Potential application of this system can be seen in the development of TTE substrates for the rapid identification of thiols by dynamic combinatorial screening.

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Steenkamp, D. J. "Simple methods for the detection and quantification of thiols from Crithidia fasciculata and for the isolation of trypanothione." Biochemical Journal 292, no. 1 (May 15, 1993): 295–301. http://dx.doi.org/10.1042/bj2920295.

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Methods for the qualitative and quantitative analysis of thiols by means of the fluorogenic reagent 7-diethylamino-3-(4′-maleimidylphenyl)-4-methylcoumarin are described, with particular reference to the trypanosomatid metabolites glutathionylspermidine (GSH-spermidine) and trypanothione. Second-order rate constants for the derivatization of seven different thiols under defined experimental conditions and at 21 degrees C varied between 619 +/- 34 and 10,560 +/- 236 M-1.s-1.T.l.c. of the thiols from Crithidia fasciculata was used to monitor the purification of trypanothione from this organism in three steps involving adsorption, ion-exchange and reversed-phase chromatography. The yield was approx. 50 mg of pure trypanothione from 100 g (wet wt.) of trypanosomatids. The method for the quantitative analysis of biological thiols is based on fluorometric detection after separation by reversed-phase or ion-paired chromatography on a phenyl-silica column. Analysis of the thiol composition of cell lysates prepared under nondenaturating conditions point to the rapid degradation of the GSH-spermidine conjugates. In addition to GSH, GSH-spermidine and trypanothione, at least one other prominent thiol was detected, and the contribution of this thiol to the total thiol content in the various growth phases of C. fasciculata was investigated.

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Liu, Zhengkun, Qianqian Wang, Hao Wang, Wenting Su, and Shouliang Dong. "A FRET Based Two-Photon Fluorescent Probe for Visualizing Mitochondrial Thiols of Living Cells and Tissues." Sensors 20, no. 6 (March 21, 2020): 1746. http://dx.doi.org/10.3390/s20061746.

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Glutathione (GSH) is the main component of the mitochondrial thiol pool and plays key roles in the biological processes. Many evidences have suggested that cysteine and homocysteine also exist in mitochondria and are interrelated with GSH in biological systems. The fluctuation of the levels of mitochondrial thiols has been linked to many diseases and cells’ dysfunction. Therefore, the monitoring of mitochondrial thiol status is of great significance for clinical studies. We report here a novel fluorescence resonance energy transfer based two-photon probe MT-1 for mitochondrial thiols detection. MT-1 was constructed by integrating the naphthalimide moiety (donor) and rhodamine B (accepter and targeting group) through a newly designed linker. MT-1 shows a fast response, high selectivity, and sensitivity to thiols, as well as a low limit of detection. The two-photon property of MT-1 allows the direct visualization of thiols in live cells and tissues by two-photon microscopy. MT-1 can serve as an effective tool to unravel the diverse biological functions of mitochondrial thiols in living systems.

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Cavalli, Federica, Lies De Keer, Birgit Huber, Paul H. M. Van Steenberge, Dagmar R. D'hooge, and Leonie Barner. "A kinetic study on the para-fluoro-thiol reaction in view of its use in materials design." Polymer Chemistry 10, no. 22 (2019): 2781–91. http://dx.doi.org/10.1039/c9py00435a.

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A detailed kinetic study on the para-fluoro-thiol reaction (PFTR) using experimental analysis and kinetic Monte Carlo modeling is introduced, covering the difference in reactivity of a selected variety of structurally different thiols, uniquely including polymeric thiols.

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Більше джерел

Дисертації з теми "Thiols"

Guo, Yixing. "Fluorescence Detection of Biological Thiols." PDXScholar, 2012. https://pdxscholar.library.pdx.edu/open_access_etds/586.

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Glutathione (GSH) is an important biological thiol, it performs significant biological functions such as serving an antioxidant which protect cells from oxidative stress by trapping free radicals which damage DNA and RNA. It is known that abnormal plasma levels of GSH have been linked to various human diseases. Therefore, the rapid, sensitive and highly selective detection of GSH is of great importance for investigating its functions in diseases diagnosis. Interestingly, we found in cetyl trimethylammonium bromide (CTAB) medium, the resorufin-based probe shows an extremely fast, highly selective response to GSH. The result indicates that this dye can be employed to detect GSH in biological samples such as human plasma. Cysteine (Cys) is another important biological thiol which is involved in a variety of significant cellur functions, including protein synthesis, detoxication, and metabolic process, etc. Abnormal levels of Cys are related to many diseases, such as slowed growth, Alzheimer's disease and cardiovascular disease. Thus, the detection and quantification of Cys in physiological media is of great importance. In this thesis, I am going to present two organic fluorescent probes (Resorufin-based probe and SNF probe) for the detection and quantification of Cys. In addition, we prove that they can directly quantify Cys in human plasma. The chemical mechanisms involved in the detection of Cys are discussed.

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Fabrega, Prats Marta. "Low-molecular-weight thiols: identification of novel thiol compounds and applications in winemaking processes." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424804.

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Thiols are reduced sulphur molecules that occur both in plants and animals with relevant roles. The thiol group is strongly nucleophilic, thus participating in a lot of biological redox processes, as for example the modulation of oxidative stress and participation to enzymatic reactions. Low-molecular-weight (LMW) thiols are a class of highly reactive compounds mainly involved in the maintenance of the redox homeostasis in the cells, thanks to the reactivity of their nucleophilic sulfur groups. In plants, they are implicated in the responses to almost all stress factors, as well as in the regulation of cell metabolism. Moreover, they can conjugate or make complexes with xenobiotics and toxic compounds (detoxification processes) and deactivate them, and they can post-translationally modify regulatory enzymes. They also have important implications in food quality and safety, as well as in human health. The most studied LMW thiols are glutathione and its biosynthetically related compounds (cysteine, gamma-glutamylcysteine and cysteinylglycine). Other LMW thiols are described in the literature, such as cysteamine, homocysteine, and many species-specific volatile thiols but less is known about them. Research shows that exists a huge amount of thiols in plants, but many species-specific and organ-specific thiols remain to be identified. Some of these unknown LMW thiols have light dependence, suggesting that they could be related to the photosynthesis processes. Recent advances in technology should help in this challenging work, helping to know the physiological and metabolic function in plants. However, their identification remains challenging due to their low concentration in plant tissues. In order to discover new unidentified thiols, in this work it was carried out a derivatization with SBD-F (ammonium 7-fluoro 2,1,3-benzooxadiazole-4-sulfonate) of the plant extracts, and then, SBD-derivatives were analyzed by HPLC-fluorescence and LC-MS/MS in negative mode using an ion trap (Varian 500 MS), to obtain their fragmentation pattern. Known LMW thiols such as cysteine, homocysteine, glutathione, cysteamine, gamma-glutamylcysteine, N-acetylcysteine and cysteinylglycine were used as reference compounds and their fragmentation pattern was first studied in order to highlight a fragmentation rule and molecular markers to systematically identify the unknown LMW thiols. Also high resolution measurements were obtained on a Xevo G-2 Q-TOF mass spectrometer (Waters). After the derivatization with the fluorophore, thiols can be easily recognized in fragmentation spectra due to the presence of a clear signal arising from the SBD-S fragment (m/z 231). This fragment corresponds to the fluorophore attached to the sulphur group from the LMW thiol. This signal was then used as a marker to confirm the presence of thiol groups in unknown molecules. In this way, some molecules could be identified and further confirmed by Q-TOF analysis; as for example the presence of thioglucose and glutathione containing derivatives. This protocol now opens the way to the identification of unknown thiol molecules. In winemaking processes, LMW thiols and specifically GSH, have an antioxidant function, which is present in grapes, must and wine. They help contrasting the oxidative browning by protecting grapes, and also the must during fermentation and the wine during the aging processes. They have a key role in the antioxidant activity by protecting wines, mostly white ones, from the oxidative process during aging. Due to this fact, in this study it was also tried to develop and optimize an easy and fast method to quantify the amount of LMW thiols in several German grape varieties (white and red). These compounds were extracted and analyzed using the fluorescent dye SBD-F and HPLC-FL separation. Also using HPLC, the sugars and organic acids were also quantified. The results of this quantification show that there is a very good reproducibility either in sampling or in the measurement of these compounds in the grape berries. This method can be also applied in must, wine and yeast. The method allowed not only the quantification of GSH, but also of its related compounds: cysteine, gamma-glutamylcysteine and cysteinylglycine in the same chromatogram, showing also the correlation between them. This study on German grape varieties is then showing that GSH is the most important LMW thiol in grapes, whose content is largely depending on the variety. Given their role as an antioxidant and possible beneficial effects during the winemaking processes, GSH and related LMW thiols are an important factor to consider in the evaluation of the grapes used for making wine.
I tioli sono composti ridotti dello zolfo che svolgono importanti funzioni in animali e piante. Il gruppo -SH è fortemente nucleofilo, per tale motivo queste molecole sono spesso coinvolte in processi biologici di ossidoriduzione, come ad esempio la modulazione degli stress ossidativi e la partecipazione a varie reazioni enzimatiche. I tioli a basso peso molecolare (LMW) sono una classe di composti coinvolti principalmente nel mantenimento dell’omeostasi ossidoriduttiva nella cellula, tale caratteristica si deve alla reattività dei loro gruppi tiolici nucleofili. Nelle piante sono coinvolti nella risposta a quasi tutti i fattori di stress e nella regolazione del metabolismo cellulare. I tioli LMW possono legarsi o creare complessi con composti tossici disattivandoli (detossificazione), inoltre possono modificare, dopo la traduzione, enzimi regolatori. Queste molecole sono implicate nella qualità e salubrità degli alimenti e anche nella salute umana. I tioli LMW più studiati sono il glutatione e i suoi composti derivati (cisteina, gamma-glutamil-cisteina e cisteinil-glicina). In letteratura sonostati descritti altri tioli LMW come la cisteammina, l’omocisteina e molti altri tioli volatili specie-specifici di cui però poco è conosciuto. In particolare, nelle piante è dimostrata la presenza di moltissimi tioli specie-specifici e organo-specifici molti dei quali però non sono ancora stati identificati. Alcuni di questi tioli LMW sconosciuti sono luce-dipendenti e ciò suggerisce un loro coinvolgimento nel processo della fotosintesi. I miglioramenti nella tecnologia potrebbero aiutare lo studio e la conoscenza della funzione fisiologica e metabolica di questi composti. Tuttavia la loro identificazione è resa ardua dalla loro bassa concentrazione nei tessuti vegetali. In questo lavoro, allo scopo di scoprire nuovi tioli non ancora identificati, sono stati derivatizati con SBD-F degli estratti di piante e in seguito i derivatizzati sono stati sottoposti ad analisi HPLC a fluorescenza e LC-MS/MS in modalità negativa usando una trappola ionica (Varian 500 MS) per ottenere la frammentazione. Sono stati usati come riferimento i tioli LMW già noti come la cisteina, l’omocisteina, il glutatione, la cisteammina, la gamma-glutamil-cisteina, l’N-acetilcisteina e la cisteinil-glicina, i cui modelli di frammentazione sono stati inizialmente studiati per evidenziare la modalità di frammentazione e i marcatori molecolari che hanno consentito la identificazione sistematica di tioli LMW sconosciuti. Inoltre è stata ottenuta la misurazione ad alta risoluzione su spettrometro di massa Q-ToF (Waters) su Xevo G-2. Dopo la derivatizzazione con fluoroforo i tioli possono essere facilmente riconosciuti dallo spettro di frammentazione per la presenza di un chiaro segnale dato dal frammento SBD-S (m/z 231). Questo frammento corrisponde al fluoroforo legato al gruppo tiolico, ed è stato usato per marcare e confermare la presenza del gruppo tiolico nelle molecole sconosciute. In questo modo le molecole possono essere identificatee poi confermate dall’analisi Q-ToF come nel caso del tioglucosio e di derivati contenenti glutatione. Il protocollo che è stato definito con il presente lavoro permette ora l’identificazione di nuovi composti dello zolfo al momento sconosciuti. Nel processo di produzione del vino, i tioli LMW e il glutatione in particolare, hanno una importante funzione antiossidante che si manifesta nell’uva, nel mosto e nel vino. I tioli contribuiscono a contrastare l’imbrunimento ossidativo delle proteine nell’uva e soprattutto nel mosto durante la fermentazione e del vino nei diversi processi di lavorazione. I tioli giocano perciò un ruolo chiave nella conservazione del vino con la loro attività antiossidante, in particolar modo nei vini bianchi. Per questa ragione è stato condotto uno studio volto a sviluppare una metodologia semplice e rapida per la quantificazione dei tioli LWM totali. In tale studio sono state poste a confronto diverse varietà tedesche di uva da vino. I composti dello zolfo sono stati estratti ed analizzati utilizzando un colorante fluorescente SBD-F e separazione HPLC-FL. Sono stati quantificati anche gli zuccheri e gli acidi organici tramite HPLC. I risultati di questa quantificazione mostrano un’elevata riproducibilità tra i campioni e tra le misurazioni di questi composti nelle bacche. Il metodo è utilizzabile anche su mosto, vino e lieviti. Il metodo permette non solo la quantificazione del glutatione ma anche di altri composti relativi nello stesso cromatogramma e mostra una correlazione tra di essi. Il confronto di varietà differenti mostra la presenza di GSH nella maggior parte dei tioli dell’uva, mentre il loro contenuto è molto influenzato dalla varietà. In considerazione del loro ruolo di antiossidanti, il GSH e i tioli LMW possono avere un ruolo favorevole nella vinificazione e sono perciò un fattore fondamentale che deve essere preso in considerazione nelle decisioni che riguardano il processo di produzione del vino.

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Kleinhenz, Joseph Patrick. "Medium and higher molecular weight volatile thiols in aged cheddar cheese and their relation to flavor." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1054657696.

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Thesis (Ph. D.)--Ohio State University, 2003.
Title from first page of PDF file. Document formatted into pages; contains xix, 181 p.; also includes graphics (some col.). Includes bibliographical references (p. 158-168). Available online via OhioLINK's ETD Center

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Nasri, Issad. "Synthèse et activité antifongique de thiols polyfonctionnels et dérivés apparentes : relation structure chimique-activité antiadhérente." Nancy 1, 1991. http://www.theses.fr/1991NAN10459.

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Emonet, Piccardi Nathalie. "Place des thiols dans la photoprotection." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE10246.

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L'irradiation ultraviolette a (uva : 320-400 nm) exerce un role potentiel dans la carcinogenese cutanee, ainsi que dans l'heliodermie, par des mecanismes impliquant les especes reactives de l'oxygene. La mise au point d'une protection efficace contre ce type de radiations devient donc une necessite en termes de sante publique. L'utilisation des topiques solaires actuels ne permet pas de garantir une protection optimale contre les uva. En dernier ressort, la protection des cellules cutanees, exposees aux uva, repose sur les systemes de la defense antiradicalaires, dont les thiols. Par une approche originale, nous avons montre les limites des photoprotecteurs externes en termes de prevention des degats genomiques et d'epargne des systemes antioxydants intracellulaires, definissant ainsi l'adn et le glutathion comme des biomarqueurs potentiels de l'efficacite reelle apportee par les topiques solaires. Par ailleurs, ce travail montre l'interet d'un apport exogene de thiols et/ou d'oligo-elements (selenium et zinc) en termes de photoprotection. La modulation redox de la synthese des proteines de stress sous uva a egalement ete apprehendee. Cette etude conduit a associer photoprotection externe et interne, dans un nouvel axe de recherche permettant la mise au point d'une photoprotection parfaite, s'opposant aux effets immediats et a longs termes de l'exposition solaire.

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Kasprzak, Scott Edward. "Small-scale polymer structures enabled by thiol-ene copolymer systems." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/28109.

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Thesis (M. S.)--Mechanical Engineering, Georgia Institute of Technology, 2009.
Committee Chair: Gall, Ken; Committee Member: Graham, Samuel; Committee Member: Jacob, Karl; Committee Member: Perry, Joe; Committee Member: Pierron, Olivier.

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Nekrassova, Olga. "Thiols specification and detection strategies via electroanalysis." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409118.

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Ellwood, Josephine Anne. "Raman band intensities of thioethers and thiols." Thesis, Royal Holloway, University of London, 1989. http://repository.royalholloway.ac.uk/items/c5538f6e-c19e-4780-a724-6bae6abecc72/1/.

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Raman spectroscopy is potentially a useful technique for the analysis of thioethers and thiols because of the characteristic set of bands which appears in the C-S stretching region. A review of previous studies on Raman band intensity measurements is presented in which the experimental difficulties and influencing factors are given. An experimental system has been developed around a Coderg PHO Raman spectrometer for the measurement of absolute Raman band intensities. This includes the novel use of a Pockels cell for the accurate determination of depolarisation ratios. Carbon tetrachloride has been assessed as a suitable internal standard for use with this system. Raman band intensities are given for five thioethers and two thiols. Several bands are identified as being characteristic of sulphur-containing hydrocarbons. Analysis of bands in the C-S stretching region is accomplished by considering the intensity contributions provided by individual groups in the molecule, resulting in a successful prediction of the C-S stretching band intensities for t-butane thiol. In addition, temperature studies have been conducted for ethyl methyl sulphide in order to attempt calculation of the energy barrier between the two conformations. A computer programme has been developed for the theoretical calculation of Raman band frequencies and intensities. Molecular parameters have been derived for dimethyl sulphide, including an ab initio force field. Tests for transferabilityof these data to ethyl methyl sulphide and deuterated dimethyl sulphide have produced encouraging results. A study of infra-red intensities of thioethers has been carried out. This is an extension of some previous work in which the necessity to resolve individual bands is eliminated. For several discrete spectral regions quantification is made of the effects of a sulphur atom on C-H band intensities, thus allowing successful intensity predictions for other molecules studied. Suggestions for further work in this field are given.

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Kading, Tristan James. "Distribution of thiols in the northwest Atlantic Ocean." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/79298.

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Thesis (Ph. D.)--Joint Program in Chemical Oceanography (Massachusetts Institute of Technology, Department of Earth, Atmospheric, and Planetary Sciences; and the Woods Hole Oceanographic Institution), 2013.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 30-38).
Thiol substances can form stable complexes with metals (especially copper and mercury) in the surface ocean that can impact cycling and bioavailability of those elements. In this study, I present seven concentration profiles of cysteine and glutathione, two low-molecular weight thiols, from the coastal northwest Atlantic Ocean and the Bermuda Atlantic Time Series (BATS) sampling site in the Sargasso Sea, a first for these regions. These two thiols were found in the upper 200 meters of the ocean at all sites, and the total thiol concentration varied from 0.2 to 3.2 nM. The highest concentration of both thiols was found at the deep chlorophyll maximum in most samples. Thiol concentrations were higher on the continental shelf than in the open ocean. The observed distribution of cysteine and glutathione and thermodynamic stability of copper complexes suggests that Cu(I)-dithiol complexes may be the dominant surface ocean copper and thiol species. Mercury-thiol complexes were also present in thermodynamically modeled seawater, which may provide a vector for mercury uptake in the surface ocean.
by Tristan Kading.
Ph.D.

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Abbas, Ewadh Mufeed-J. A. "The involvement of thiols in endothelial cell toxicity." Thesis, Cardiff University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316383.

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Книги з теми "Thiols"

L, Newton Gerald, and United States. National Aeronautics and Space Administration., eds. Determination of low molecular weight thiols using monobromobimane fluorescent labeling and high-performance liquid chromatography. [Washington, DC]: National Aeronautics and Space Administration, 1988.

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Magerramov, A. M. Aminotioly i ikh proizvodnye. Baku: Izdatelʹstvo Bakinskogo universiteta, 2007.

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Aliyev, Ismayil A., Boris A. Trofimov, and Lyudmila A. Oparina. Aromatic Thiols and Their Derivatives. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-69621-4.

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Lester, Packer, ed. Biothiols.: Thiols in signal transduction and gene regulation. San Diego: Academic Press, 1995.

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1942-, Sies H., and Packer Lester, eds. Protein sensors and reactive oxygen species. San Diego, Calif: Academic Press, 2002.

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Chin, Tracy Alexandra. Toxicity of cadmium to cultured rat mesangial cells and protection by intracellular thiols. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1993.

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patterson, Steven. Homocysteine and the effects of other amino thiols on pancreatic beta cell function and insulin. [S.l: The Author], 2003.

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NATO Advanced Research Workshop on Thiol Metabolism and Redox Regulation of Cellular Functions (2002 Pisa, Italy). Thiol metabolism and redox regulation of cellular functions. Amsterdam: IOS Press, 2002.

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Lindqvist, Thomas. N-oxidation of 4-ethoxyaniline: Identification of oxidation products, their cellular effects and reactions with thiols. Uppsala: Univ., 1991.

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Schupp, Robert. Untersuchungen zur Schwefelernährung der Fichte (Picea abies L.): Die Bedeutung der Sulfatassimilation und des Transports von Thiolen. Frankfurt/M: Wissenschafts-Verlag Dr. W. Maraun, 1991.

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Частини книг з теми "Thiols"

Mehlhorn, Heinz. "Thiols." In Encyclopedia of Parasitology, 2678–79. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-43978-4_3161.

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Mehlhorn, Heinz. "Thiols." In Encyclopedia of Parasitology, 1–2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27769-6_3161-2.

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Pala, Nezih, Ahmad Nabil Abbas, Carsten Rockstuhl, Christoph Menzel, Stefan Mühlig, Falk Lederer, Joseph J. Brown, et al. "Thiols." In Encyclopedia of Nanotechnology, 2742. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-90-481-9751-4_100857.

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Smith, Robert M., and Arthur E. Martell. "Thiols." In Critical Stability Constants, 414–15. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4615-6764-6_19.

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Brown, Lou Ann S., and Dean P. Jones. "Glutathione and Thiols." In Oxidative Stress in Applied Basic Research and Clinical Practice, 131–47. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-19096-9_7.

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Huxtable, Ryan J. "Thiols, Disulfides, and Thioesters." In Biochemistry of Sulfur, 199–268. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-9438-0_5.

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Aliyev, Ismayil A., Boris A. Trofimov, and Lyudmila A. Oparina. "Synthesis of Aromatic Thiols." In Aromatic Thiols and Their Derivatives, 1–20. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-69621-4_1.

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Forman, Henry Jay. "Assays for Thiols and Modifications." In Measuring Oxidants and Oxidative Stress in Biological Systems, 3–6. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-47318-1_1.

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Langmuir, Margaret E., Jun-Rui Yang, Karen A. LeCompte, and Ralph E. Durand. "New Thiol Active Fluorophores for Intracellular Thiols and Glutathione Measurement." In Fluorescence Microscopy and Fluorescent Probes, 229–33. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-1866-6_34.

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Fackler, J. P., and K. G. Fackler. "From Hydrogen Sulfide, Polysulfides, and Thiols." In Inorganic Reactions and Methods, 86–89. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470145203.ch74.

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Тези доповідей конференцій з теми "Thiols"

Kosmachevskaya, Olga Vladimirovna, Elvira Ilgizovna Nasybullina, Natalya Nikolaevna Novikova, Konstantin Borisovich Shumaev, and Alexey Fedorovich Topunov. "HEMOGLOBIN THIOLS: BIOLOGICAL SIGNIFICANCE AND REGULATION." In International conference New technologies in medicine, biology, pharmacology and ecology (NT +M&Ec ' 2020). Institute of information technology, 2020. http://dx.doi.org/10.47501/978-5-6044060-0-7.20.

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Анотація:

Human hemoglobin has two reactive cysteines (Cys-93β) located on the surface of the molecule. Inclusion of these thiols in the composition of dinitrosyl iron complexe is one way of regulating their reactivity. The thiols bound into complexes exhibit enhanced reactivity with electrophiles and are protected from oxidation by tert-butyl hydroperoxide.

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Garrell, Robin L., Cory Szafranski, and Weslene Tanner. "Surface-enhanced Raman spectroscopy of thiols and disulfides." In San Dieg - DL Tentative, edited by Fran Adar and James E. Griffiths. SPIE, 1990. http://dx.doi.org/10.1117/12.22917.

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Juanes, Marcos, Josï¾Ž Fernï¾‡ndez, Alberto Lesarri, and Rizalina Saragi. "SULFUR HYDROGEN BONDING IN THE OLIGOMERS OF AROMATIC THIOLS." In 74th International Symposium on Molecular Spectroscopy. Urbana, Illinois: University of Illinois at Urbana-Champaign, 2019. http://dx.doi.org/10.15278/isms.2019.tb03.

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Pattabi, Rani M., Manjunatha Pattabi, Alka B. Garg, R. Mittal, and R. Mukhopadhyay. "Visible Luminescence from Au Nanoparticles Stabilized with Aromatic Thiols." In SOLID STATE PHYSICS, PROCEEDINGS OF THE 55TH DAE SOLID STATE PHYSICS SYMPOSIUM 2010. AIP, 2011. http://dx.doi.org/10.1063/1.3605888.

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Ruths, M., and Y. Yang. "Friction of Aromatic Thiols in Contacts of Different Adhesive Strength." In ASME/STLE 2007 International Joint Tribology Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/ijtc2007-44410.

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We have used friction force microscopy to study the boundary friction of thiophenol and 2-napthalenethiol monolayers on gold. The strength of the adhesion was altered by working in dry N2 gas or in ethanol. A contact mechanics model developed by Sridhar, Johnson and Fleck1,2 (SJF) for a thin, compliant elastic film confined between stiffer substrates was used to evaluate the data in systems with higher adhesion.

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Wang, Meng, and Guangyou Zhu. "Occurrence and Origins of Thiols in Deep Strata Crude Oils." In Goldschmidt2020. Geochemical Society, 2020. http://dx.doi.org/10.46427/gold2020.2740.

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Lavayen, V. "Towards of Vanadium Pentoxide Nanotubes and Thiols using Gold Nanoparticles." In ELECTRONIC PROPERTIES OF NOVEL NANOSTRUCTURES: XIX International Winterschool/Euroconference on Electronic Properties of Novel Materials. AIP, 2005. http://dx.doi.org/10.1063/1.2103889.

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Hodlur, R. M., M. K. Rabinal, H. H. Bendigeri, S. S. Banappanavar, M. N. Kalasad, Alka B. Garg, R. Mittal, and R. Mukhopadhyay. "Thiols as Effective Capping Molecules to Synthesize High-Quality ZnO Nanocrystals." In SOLID STATE PHYSICS, PROCEEDINGS OF THE 55TH DAE SOLID STATE PHYSICS SYMPOSIUM 2010. AIP, 2011. http://dx.doi.org/10.1063/1.3605836.

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Lang, P., Z. Mekhalif, F. Garnier, and A. Regis. "Bipolar thiols as coupling agent for the grafting of conducting polymers." In The proceedings of the 53rd international meeting of physical chemistry: Organic coatings. AIP, 1996. http://dx.doi.org/10.1063/1.49465.

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NICHICK, M. N., S. V. VOITEKHOVICH, and O. A. IVASHKEVICH. "PREPARATION AND SOME PROPERTIES OF Pd NANOPARTICLES CAPPED WITH TETRAZOLE-5-THIOLS." In Proceedings of International Conference Nanomeeting – 2011. WORLD SCIENTIFIC, 2011. http://dx.doi.org/10.1142/9789814343909_0090.

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Звіти організацій з теми "Thiols"

Guo, Yixing. Fluorescence Detection of Biological Thiols. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.586.

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Adigun, Risikat. Insight into the Reactivity of Metastasis Inhibitor, Imidazolium trans-[tetrachloro (dimethyl sulfoxide)(imidazole)ruthenate(III)], with Biologically-active Thiols. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.378.

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Voas, Jeffrey M. Networks of 'things'. Gaithersburg, MD: National Institute of Standards and Technology, 2016. http://dx.doi.org/10.6028/nist.sp.800-183.

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Balakrishna Rao, Vismayashree. Internet of Things. Ames (Iowa): Iowa State University, January 2019. http://dx.doi.org/10.31274/cc-20240624-918.

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Rogers, J. (Processing and targeting of the thiol protease aleurain). Office of Scientific and Technical Information (OSTI), January 1990. http://dx.doi.org/10.2172/6995327.

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Rogers, J. C. [Processing and targeting of the thiol protease aleurain]. Office of Scientific and Technical Information (OSTI), January 1993. http://dx.doi.org/10.2172/6619862.

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Greenfield, S. Remembrances of Things Past. RFC Editor, February 1992. http://dx.doi.org/10.17487/rfc1300.

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Longstaff, Francis. Valuing Thinly-Traded Assets. Cambridge, MA: National Bureau of Economic Research, October 2014. http://dx.doi.org/10.3386/w20589.

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Farrell, S., D. Kutscher, C. Dannewitz, B. Ohlman, A. Keranen, and P. Hallam-Baker. Naming Things with Hashes. RFC Editor, April 2013. http://dx.doi.org/10.17487/rfc6920.

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Fitzpatrick, Charlien. Things seen and remembered. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.5750.

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