Готові списки джерел за темами / T-CAD

Добірка наукової літератури з теми "T-CAD"

Автор: Grafiati
Опубліковано: 11 вересня 2023

Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями

Оберіть тип джерела:

Зміст

Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "T-CAD".

Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.

Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.

Статті в журналах з теми "T-CAD"

1

Uhm, Tae-Kyoung, Ki-Seung Kim, Yu-Deok Seo, and Sung-Kie Youn. "T-spline Finite Element Method for CAD/CAE Integrated Approach." Transactions of the Korean Society of Mechanical Engineers A 33, no. 2 (February 1, 2009): 127–34. http://dx.doi.org/10.3795/ksme-a.2009.33.2.127.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
2

Netto, Jeffrey, Andrej Teren, Ralph Burkhardt, Anja Willenberg, Frank Beutner, Sylvia Henger, Gerhard Schuler, et al. "Biomarkers for Non-Invasive Stratification of Coronary Artery Disease and Prognostic Impact on Long-Term Survival in Patients with Stable Coronary Heart Disease." Nutrients 14, no. 16 (August 20, 2022): 3433. http://dx.doi.org/10.3390/nu14163433.

Повний текст джерела
Анотація:
Knowledge about cardiac and inflammatory biomarkers in patients with stable coronary artery disease (CAD) is limited. To address this, we analyzed 3072 patients (36% female) with a median follow-up of 10 years in the Leipzig LIFE Heart Study with suspected CAD with coronary angiography. Selected biomarkers included troponin T (hsTNT), N-terminal pro B-type natriuretic peptide (NT-proBNP), copeptin, C-reactive protein (hsCRP), and interleukin-6 (IL-6). Patients were stratified by CAD severity: CAD0 (no sclerosis), CAD1 (non-obstructive, i.e., stenosis < 50%), and CAD2 (≥one stenosis ≥ 50%). Group comparison (GC) included GC1: CAD0 + 1 vs. CAD2; GC2: CAD0 vs. CAD1 + 2. CAD0, CAD1, and CAD2 were apparent in 1271, 631, and 1170 patients, respectively. Adjusted for classical risk factors, hs-cTnT, NT-proBNP, and IL-6 differed significantly in both GC and hsCRP only in GC2. After multivariate analysis, hs-cTnT, NT-proBNP, and IL-6 remained significant in GC1. In GC2, hs-cTnT (p < 0.001) and copeptin (p = 0.014) reached significance. Ten-year survival in groups CAD0, CAD1, and CAD2 was 88.3%, 77.3%, and 72.4%. Incorporation of hs-cTnT, NT-proBNP, copeptin, and IL-6 improved risk prediction (p < 0.001). The studied cardiac and inflammatory biomarkers enable fast and precise non-invasive identification of mortality risk in CAD patients, allowing the tailoring of primary and secondary CAD prevention.
Стилі APA, Harvard, Vancouver, ISO та ін.
3

Lloyd, Peter, Colin C. McAndrew, Michael J. McLennan, Sani R. Nassif, Kishore Singhal, Kumud Singhal, Peter M. Zeitzoff, et al. "Technology CAD at AT&T." Microelectronics Journal 26, no. 2-3 (March 1995): 79–97. http://dx.doi.org/10.1016/0026-2692(95)98915-e.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
4

Baltrūnienė, Vaida, Ieva Rinkūnaitė, Julius Bogomolovas, Daiva Bironaitė, Ieva Kažukauskienė, Egidijus Šimoliūnas, Kęstutis Ručinskas, Roma Puronaitė, Virginija Bukelskienė, and Virginija Grabauskienė. "The Role of Cardiac T-Cadherin in the Indicating Heart Failure Severity of Patients with Non-Ischemic Dilated Cardiomyopathy." Medicina 56, no. 1 (January 9, 2020): 27. http://dx.doi.org/10.3390/medicina56010027.

Повний текст джерела
Анотація:
Background and objectives: T-cadherin (T-cad) is one of the adiponectin receptors abundantly expressed in the heart and blood vessels. Experimental studies show that T-cad sequesters adiponectin in cardiovascular tissues and is critical for adiponectin-mediated cardio-protection. However, there are no data connecting cardiac T-cad levels with human chronic heart failure (HF). The aim of this study was to assess whether myocardial T-cad concentration is associated with chronic HF severity and whether the T-cad levels in human heart tissue might predict outcomes in patients with non-ischemic dilated cardiomyopathy (NI-DCM). Materials and Methods: 29 patients with chronic NI-DCM and advanced HF were enrolled. Patients underwent regular laboratory investigations, echocardiography, coronary angiography, and right heart catheterization. TNF-α and IL6 in serum were detected by enzyme-linked immunosorbent assay (ELISA). Additionally, endomyocardial biopsies were obtained, and the levels of T-cad were assessed by ELISA and CD3, CD45Ro, CD68, and CD4- immunohistochemically. Mean pulmonary capillary wedge pressure (PCWP) was used as a marker of HF severity, subdividing patients into two groups: mean PCWP > 19 mmHg vs. mean PCWP < 19 mmHg. Patients were followed-up for 5 years. The study outcome was composite: left ventricular assist device implantation, heart transplantation, or death from cardiovascular causes. Results: T-cad shows an inverse correlation with the mean PCWP (rho = −0.397, p = 0.037). There is a tendency towards a lower T-cad concentration in patients with more severe HF, as indicated by the mean PCWP > 19 mmHg compared to those with mean PCWP ≤ 19 mmHg (p = 0.058). Cardiac T-cad levels correlate negatively with myocardial CD3 cell count (rho = −0.423, p = 0.028). Conclusions: Univariate Cox regression analysis did not prove T-cad to be an outcome predictor (HR = 1, p = 0.349). However, decreased T-cad levels in human myocardium can be an additional indicator of HF severity. T-cad in human myocardium has an anti-inflammatory role. More studies are needed to extend the role of T-cad in the outcome prediction of patients with NI-DCM.
Стилі APA, Harvard, Vancouver, ISO та ін.
5

Fukuda, Shiro, Shunbun Kita, Kazuya Miyashita, Masahito Iioka, Jun Murai, Tadashi Nakamura, Hitoshi Nishizawa, et al. "Identification and Clinical Associations of 3 Forms of Circulating T-cadherin in Human Serum." Journal of Clinical Endocrinology & Metabolism 106, no. 5 (February 4, 2021): 1333–44. http://dx.doi.org/10.1210/clinem/dgab066.

Повний текст джерела
Анотація:
Abstract Context T-cadherin (T-cad) is a glycosylphosphatidylinositol (GPI)-anchored cadherin that mediates adiponectin to induce exosome biogenesis and secretion, protect cardiovascular tissues, promote muscle regeneration, and stimulate therapeutic heart protection by transplanted mesenchymal stem cells. CDH13, the gene locus of T-cad, affects plasma adiponectin levels most strongly, in addition to affecting cardiovascular disease risk and glucose homeostasis. Recently, it has been suggested that T-cad exists in human serum, although the details are still unclear. Objective To validate the existence of T-cad forms in human serum and investigate the association with clinical parameters of type 2 diabetes patients. Methods Using newly developed monoclonal antibodies against T-cad, pooled human serum was analyzed, and novel T-cad enzyme-linked immunosorbent assays (ELISAs) were developed. The serum T-cad concentrations of 183 Japanese type 2 diabetes patients were measured in a cross-sectional observational study. The main outcome measure was the existence of soluble T-cad in human serum. Results There were 3 forms of soluble T-cad: a 130-kDa form with a prodomain, a 100-kDa mature form, and a 30-kDa prodomain in human serum. Using newly developed ELISAs to measure them simultaneously, we found that the 130-kDa form of T-cad positively correlated with plasma adiponectin (r = 0.28, P &lt; .001), although a physiological interaction with adiponectin was not observed in serum. The unique 30-kDa prodomain was associated with several clinical parameters in diabetes patients. Conclusion We identified 3 novel forms of soluble T-cad. Their importance as disease markers and/or biomarkers of adiponectin function and the possible bioactivity of the respective molecules require further investigation.
Стилі APA, Harvard, Vancouver, ISO та ін.
6

Philippova, Maria, Danila Ivanov, Manjunath B. Joshi, Emmanouil Kyriakakis, Katharina Rupp, Taras Afonyushkin, Valery Bochkov, Paul Erne, and Therese J. Resink. "Identification of Proteins Associating with Glycosylphosphatidylinositol- Anchored T-Cadherin on the Surface of Vascular Endothelial Cells: Role for Grp78/BiP in T-Cadherin-Dependent Cell Survival." Molecular and Cellular Biology 28, no. 12 (April 14, 2008): 4004–17. http://dx.doi.org/10.1128/mcb.00157-08.

Повний текст джерела
Анотація:
ABSTRACT There is scant knowledge regarding how cell surface lipid-anchored T-cadherin (T-cad) transmits signals through the plasma membrane to its intracellular targets. This study aimed to identify membrane proteins colocalizing with atypical glycosylphosphatidylinositol (GPI)-anchored T-cad on the surface of endothelial cells and to evaluate their role as signaling adaptors for T-cad. Application of coimmunoprecipitation from endothelial cells expressing c-myc-tagged T-cad and high-performance liquid chromatography revealed putative association of T-cad with the following proteins: glucose-related protein GRP78, GABA-A receptor α1 subunit, integrin β3, and two hypothetical proteins, LOC124245 and FLJ32070. Association of Grp78 and integrin β3 with T-cad on the cell surface was confirmed by surface biotinylation and reciprocal immunoprecipitation and by confocal microscopy. Use of anti-Grp78 blocking antibodies, Grp78 small interfering RNA, and coexpression of constitutively active Akt demonstrated an essential role for surface Grp78 in T-cad-dependent survival signal transduction via Akt in endothelial cells. The findings herein are relevant in the context of both the identification of transmembrane signaling partners for GPI-anchored T-cad as well as the demonstration of a novel mechanism whereby Grp78 can influence endothelial cell survival as a cell surface signaling receptor rather than an intracellular chaperone.
Стилі APA, Harvard, Vancouver, ISO та ін.
7

Khanna, Roopali, Avinash Bansal, Sudeep Kumar, Naveen Garg, Satyendra Tewari, Aditya Kapoor, and Pravin K. Goel. "Association between Endogenous Sex Hormones and Coronary Artery Disease in Postmenopausal Women." Indian Journal of Cardiovascular Disease in Women - WINCARS 06, no. 03 (July 2021): 168–73. http://dx.doi.org/10.1055/s-0041-1736250.

Повний текст джерела
Анотація:
Background Incidence of coronary artery disease (CAD) increases significantly in postmenopausal women, which is assumed to be an imbalance between serum androgen and estrogen levels. However, studies assessing serum sex hormones and CAD are few and have shown conflicting results. Objective To compare serum sex hormone levels and traditional risk factors among postmenopausal women with angiographically proven CAD and without CAD. Method The study included consecutive postmenopausal women undergoing coronary angiography in our institute from May 2016 to June 2017. The clinical and coronary angiographic data and traditional risk factors were assessed. Fasting serum levels of estradiol (E2), testosterone (T), sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEA-S), and insulin were measured. Results A total of 121 postmenopausal women were included in the study; 69 were CAD and 52 without CAD. Single-vessel disease was most common (55.1%), followed by double-vessel disease (24.6%) and triple-vessel disease (20.3%). Women with CAD had significantly lower estradiol/testosterone (E2/T) ratio (3.7 ± 2.6 vs. 5.4 ± 4.2, p = 0.008) compared with non-CAD group. SHBG, DHEA-S, and insulin levels were similar in CAD and non-CAD groups. The serum level of estradiol predicted the E2/T ratio (r = 0.316, p < 0.001) and positively associated with DHEA (r = 0.181, p = 0.047). Testosterone was negatively associated with E2/T ratio (r = – 0.682, p < 0.001). There was no significant correlation of estrogen, testosterone, or E2/T ratio to lipid profile (total cholesterol, HDL, LDL) in women with CAD. Conclusion E2/T ratio was significantly lowered in postmenopausal women with CAD. E2/T ratio may be a used a predictor of CAD in postmenopausal women
Стилі APA, Harvard, Vancouver, ISO та ін.
8

Labay, V. A., and J. Bornemann. "CAD of T-septum waveguide evanescent-mode filters." IEEE Transactions on Microwave Theory and Techniques 41, no. 4 (April 1993): 731–33. http://dx.doi.org/10.1109/22.231675.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
9

Foster, Jeffrey C. "CAE/CAD at AT&T: An Introduction." AT&T Technical Journal 70, no. 1 (January 2, 1991): 2–8. http://dx.doi.org/10.1002/j.1538-7305.1991.tb00493.x.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
10

Abu-Amero, Khaled K., Carol A. Wyngaard, and Nduna Dzimiri. "Prevalence and Role of Methylenetetrahydrofolate Reductase 677 C→T and 1298 A→C Polymorphisms in Coronary Artery Disease in Arabs." Archives of Pathology & Laboratory Medicine 127, no. 10 (October 1, 2003): 1349–52. http://dx.doi.org/10.5858/2003-127-1349-paromr.

Повний текст джерела
Анотація:
Abstract Context.—Previous studies reported an association of 677 C→T and 1298 A→C methylenetetrahydrofolate reductase (MTHFR) variants with coronary artery disease (CAD). No previous studies concerning the prevalence of these 2 MTHFR variants or their possible association with CAD in Arabs are currently available in the literature. Objective.—To determine the prevalence of MTHFR variants and their potential relevance to CAD among Arabs. Design.—We used polymerase chain reaction and restriction enzyme digestion to determine the prevalence of these 2 MTHFR polymorphisms in 625 healthy blood donors (BDs) and 545 angiographically confirmed CAD patients of Arab origin. Results.—For the 677 C→T variant within the CAD group, 64.2% were homozygous wild-type C/C, 32.1% were heterozygous C/T, and 3.7% were homozygous T/T genotype. Within the BD group tested for the 677 C→T variant, 72.2% were homozygous wild-type C/C, 25.8% were heterozygous C/T, and 2% were homozygous T/T genotype. Within the CAD group tested for the 1298 A→C variant (n = 540), 45.7% were homozygous wild-type A/A, 46.9% were heterozygous A/C, and 7.4% were homozygous C/C genotype. Within the BD group tested for the 1298 A→C variant (n = 625), 39.4% were homozygous wild-type A/A, 51.5% were heterozygous A/C, and 9.1% were homozygous C/C genotype. The distribution and allele frequency of these 2 MTHFR variants followed the Hardy-Weinberg equilibrium and were similar in the CAD and BD study groups. The prevalence of the 677 C→T and 1298 A→C compound heterozygosity was 9.6% for the BD group and 12.3% for the CAD group. Conclusion.—The 2 MTHFR variants tested in this study, individually or compound, are not associated with CAD. Therefore, neither of these 2 variants can be considered an independent risk factor or a predictor for CAD in this population.
Стилі APA, Harvard, Vancouver, ISO та ін.
Більше джерел

Дисертації з теми "T-CAD"

1

McGarry, Anthony. "Evaluation of the Tracer CAD and T ring prosthetic shape capture systems." Thesis, University of Strathclyde, 2009. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=11251.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
2

SONI, HARSHIT. "DESIGN AND STUDY OF NANOSCALE TRENCHED GATE MOSFET." Thesis, DELHI TECHNOLOGICAL UNIVERSITY, 2020. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18379.

Повний текст джерела
Анотація:
This Project presents T-CAD simulation of buffered trench gate MOSFET (BTG-MOSFET), and GaN buffered trench gate MOSFET (GaN-BTG MOSFET). The electrical attributes of the devices are contrasted with conventional trench gate MOSFET (CTG-MOSFET). A comparative study between various performance factors, for example, electric field, electron velocity, electron mobility, the threshold voltage (Vth), and sub-threshold swing (SS) of the devices has been performed. Results uncover a 43.85% improvement in SS and 9.83% decrement in Vth for GaN-BTG-MOSFET. Further in this report, GaN-BTG-MOSFET’s parameters are concentrated with variation in channel length, Effective Oxide thickness (tox), and Doping concentration. Thermal reliability of GaN- BTG-MOSFET for application in Integrated Circuits (ICs) at high temperatures (300K to 600 K) is examined. An intensive near examination of electrical characteristics GaN-BTG-MOSFET has been carried out. GaN-BTG MOSFET acts as a promising structure for further downsizing of the trenched gate MOSFET and guarantees better performance for sub-micrometer MOSFET. Thermal reliability of GaN-BTG-MOSFET for application in Integrated Circuits (ICs) at high temperatures (300K to 600K). An intensive relative investigation of electrical characteristics, for example, transconductance, transfer characteristics, leakage current, and the electric field of the designed devices have been performed using the TCAD Atlas tool. A detailed discussion is introduced on the thermal stability of the device at high temperatures (300-600K). Report additionally presents the performance factors, for example, On- Resistance (Ron), leakage current, and threshold voltage (Vth). Results recommend that the introduction of GaN instead of silicon in a trenched gate structure not just improves the device’s performance at room temperature (300K) yet additionally enhances the thermal stability of the device. The performance of GaN-BTG-MOSFET at high temperatures when contrasted with CTG MOSFET suggests that it tends to be utilized in ICs and shows preferred thermal stability than silicon-based devices.
Стилі APA, Harvard, Vancouver, ISO та ін.
3

Ferrari, Giacomo. "Metodi numerici per superfici T-Spline." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amslaurea.unibo.it/5913/.

Повний текст джерела
Анотація:
Questo lavoro di tesi riguarda lo studio e la realizzazione dei principali algoritmi di rappresentazione e modellazione di superfici T-Spline. In particolare si è cercato di determinare i vantaggi e gli svantaggi che queste superfici presentano rispetto alle superfici NURBS, utilizzate nei software CAD.
Стилі APA, Harvard, Vancouver, ISO та ін.
4

Font, Andreu Jordi. "Impacto tecnológico del CAD en la docencia de la expresión gráfica en la Ingeniería." Doctoral thesis, Universitat de Barcelona, 2007. http://hdl.handle.net/10803/1263.

Повний текст джерела
Анотація:
El presente trabajo de investigación tiene por objeto analizar el impacto tecnológico del Diseño Asistido por Ordenador en la docencia de la Ingeniería Gráfica. El trabajo se centra en los cambios metodológicos y en las más importantes consecuencias que ha comportado la aparición de una nueva herramienta de diseño respecto a la práctica y los contenidos del Área de conocimiento de Ingeniería Gráfica.

Se han tratado datos disponibles de los centros públicos del territorio español desde la implantación de los planes de estudios de 1993.

Para el presente estudio se han tenido en cuenta los acontecimientos más importantes producidos en el entorno universitario nacional, entre los que cabe destacar los siguientes:

· Elaboración y aplicación de los nuevos planes de estudios

· Reducción de las horas lectivas por asignatura (de veintiocho semanas por curso en el plan de 1964 a 15 semanas en los planes posteriores a 1993).

· Incorporación de la docencia del Dibujo Asistido por Ordenador en aplicación de los descriptores del Boletín Oficial del Estado (BOE), a partir de 1993.
· Expansión del Diseño Asistido por Ordenador (CAD 3D) paramétrico, a raíz de la migración de estaciones de trabajo a ordenadores personales a mediados de 1995.
· Introducción paulatina de las nuevas Tecnologías de la Comunicación y de la Información (TIC) en las aulas.
· Instalación de aulas informáticas con acceso a Internet.
· Proliferación de Aplicaciones Didácticas Interactivas (ADI) como recurso metodológico en la docencia y el aprendizaje.
· Reformas realizadas de los planes de estudios vigentes para la adaptación al Proceso de Bolonia.

Dichas transformaciones en el marco de la enseñanza han propiciado que se revisen los objetivos, los contenidos y los métodos empleados en la docencia, para dar respuesta a las necesidades que se promueven desde las instituciones, la industria y el conjunto de la sociedad en general.

Se detalla la programación de las asignaturas de Ingeniería Gráfica a partir de la localización de las guías académicas disponibles de los centros donde se imparten ingenierías. Se analizan los objetivos y los contenidos de dichas asignaturas en los centros docentes que se han tomado de referencia. Se muestran ejercicios de prácticas y se exponen los contenidos necesarios para resolverlos mediante herramientas manuales y digitales, con la finalidad de destacar los diferentes métodos empleados. Se describen los contenidos utilizados en el modelado geométrico 3D y se estudian los métodos empleados en el sistema diédrico en combinación con los propios del CAD 3D. Por último, se muestran los cuerpos y superficies más habituales en el estudio de la geometría, así como los elementos constructivos y las operaciones más comunes en la generación de los modelos en 3D.

En las conclusiones se recogen las consecuencias más relevantes del impacto del CAD en la docencia de la Ingeniería Gráfica. Se exponen los argumentos que se desprenden del análisis de los datos aportados y que corroboran los objetivos y las hipótesis formuladas. Se plantean y se apuntan posibles líneas de investigación a desarrollar en un futuro.
"The technological impact of CAD on the teaching of Graphic Expression in Engineering"

TEXT:

This study focuses on the methodological changes brought about by the appearance of the new design tool CAD 3D and the very important consequences it has had on brought about by the appearance of the new design tool CAD 3D regarding the practice and the contents of the field of Graphic Engineering.
The syllabi of the Graphic Engineering courses in engineering schools are described. The aims and the contents of said subjects are analysed. Typical practical exercises from the courses are shown and their solution using both manual and digital tools is discussed with the aim of reflecting on and analysing the differences between the methods employed.
The materials used in 3D geometric modelling are described, and the methods employed by the dihedral system are studied in combination with those used by CAD 3D. Lastly, the construction elements and the most common operations used in the generation of 3D models are shown.
The most relevant consequences of the impact of CAD on the teaching of Graphic Engineering are detailed in the conclusion. The ideas born from the analysis ofA discussion of the results shows that the data collected and which corroborate the aims and the hypotheseis of the thesis are defended. Possible avenues for future research to develop are suggested.
Стилі APA, Harvard, Vancouver, ISO та ін.
5

BESERRA, Simone Ataíde. "Influência do tipo e do tempo de duração de cura nas propriedades mecânicas de concretos de alto desempenho (CAD) produzidos em períodos quente (t>25°C) e de baixa umidade relativa do ar (h<50%)." Universidade Federal de Goiás, 2005. http://repositorio.bc.ufg.br/tede/handle/tde/686.

Повний текст джерела
Анотація:
Made available in DSpace on 2014-07-29T15:03:41Z (GMT). No. of bitstreams: 1 Dissertacao Simone Ataide Beserra.pdf: 2438283 bytes, checksum: abbcdf2cacf8c82fb112904e30a3c176 (MD5) Previous issue date: 2005-06-07
In the case of conventional concrete, small constructive defects, variations of mix proportion or even inadequate curings can not compromise significantly the material. No longer HPC demands a severity in the control since its dosage until the execution, therefore any imperfection can bring serious damages to the material or the structure. Amongst the relative aspects most important to the total quality of any concrete it is the curing, that becomes basic when is about HPC. The curing of the high performance concrete constitutes in a controversial subject in the technician area as well as the type and duration of it, therefore the necessity of a deeper refined study on this subject. This research verifies the influence of the type and time of duration of curing in the mechanical properties of the HPC (compressive strength, flexion tensile strength and module of deformation), produced in Goiânia in hot period (t>25ºC) and of low relative humidity of air (h<50%) situation this considered critical for NBR 14931/2003 and predominant in the months of May the September in this region. In the experimental study were produced HPC of target compressive strength 60, 80 and 100MPa, from the Furnas Mix Proportion Method, using cement CP II-F-32, silica fume, polycarboxylate based superplasticizer, natural sand and crushed stones nº 0 of the granulite. 14 cures of different type and times of duration had been applied: curing with permanence of 1, 3, 7, 14, and 28 days inside of the humid chamber; curing with aspersion of water during 1, 3, 7, 14 and 28 days; chemical curing based on paraffin and chemical curing based on chloride rubber; cure for aspersion of water during 7 days and later sealing of the part with membrane of curing based on chloride rubber and air curing. For concretes of target compressive strength to the 28 days of 60 MPa and 80 MPa, the best type of curing was "saw humid" (curing in humid chamber and curing with aspersion of water) and the best time of duration humid was 7 days. For the one of 100 MPa the best type of curing also was "saw humid", however the duration time was 14 days. According to the chemical curing, some times the results had been even though less than to the one of reference (air curing). Among the two types of used chemical curing, difference in the results of compressive strength was not verified, despite the chemical membrane based on paraffin has an inferior cost to the chloride rubber base.
No caso de concreto convencional, pequenos defeitos construtivos, variações de dosagem ou mesmo curas inadequadas podem não comprometer significativamente o material. Já no CAD exige-se um rigor no controle desde sua dosagem até a execução, pois qualquer falha pode trazer sérios prejuízos ao material ou a estrutura. Dentre os aspectos mais importantes relativos à qualidade total de qualquer concreto está a cura, o que se torna fundamental quando se trata de CAD. A cura do concreto de alto desempenho constitui assunto polêmico no meio técnico assim como o tipo e duração desta, por isso a necessidade de um estudo mais apurado sobre este tema. Esta pesquisa verifica a influência do tipo e tempo de duração de cura nas propriedades mecânicas do CAD (resistência à compressão, resistência à tração na flexão e módulo de deformação), produzidos em Goiânia em período quente (t>25ºC) e de baixa umidade relativa do ar (h<50%), situação esta considerada crítica pela norma NBR 14931 (ABNT, 2003) e predominante nos meses de maio a setembro na região. No estudo experimental foram produzidos CAD de resistência à compressão estimada 60, 80 e 100MPa, a partir do Método de Dosagem de Furnas, utilizando cimento CP II-F-32, sílica ativa, superplastificante à base de éter carboxilato, areia natural e brita 0 de granulito. Foram aplicados 14 curas de diferentes tipos e tempos de duração: cura com permanência de 1, 3, 7, 14, e 28 dias dentro da câmara úmida; cura através de aspersão de água durante 1, 3, 7, 14 e 28 dias; cura química com membrana à base de parafina e à base de borracha clorada; cura através de aspersão de água durante 7 dias e depois selagem da peça com membrana de cura à base de borracha clorada e cura ao ar. Para os concretos de resistência estimada aos 28 dias de 60 MPa e de 80 MPa, o melhor tipo de cura foi via úmida (cura em câmara úmida e cura através de aspersão de água) e o melhor tempo de duração foi 7 dias. Para o de 100 MPa o melhor tipo de cura também foi via úmida , porém o tempo de duração foi 14 dias. Quanto à cura química, algumas vezes os resultados foram até mesmo inferiores ao de referência (cura ao ar). Dentre os dois tipos de curas químicas utilizados não verificouse diferença nos resultados de resistência à compressão, salientando-se que a membrana química à base de parafina tem custo inferior à base de borracha clorada.
Стилі APA, Harvard, Vancouver, ISO та ін.
6

Samakai, Elsie. "TRANSCRIPTIONAL CONTROL OF Ca2+ SIGNALING IN T CELLS." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/466164.

Повний текст джерела
Анотація:
Biochemistry
Ph.D.
Antigen presentation to T cells results in their activation through T Cell Receptor (TCR) stimulation, resulting in sustained elevation of cytosolic Ca2+ concentration critical for T cell activation. Sustained Ca2+ signals are important for the activation of Nuclear Factor of Activated T cells (NFAT), which is a key regulator of T cell activation through its transcriptional control of genes in multiple process including cytokine production, proliferation and differentiation(Rao, Luo, & Hogan, 1997). Recently it was shown that Stromal Interaction Molecule 1 (STIM1) inhibits plasma membrane Ca2+/ATPase 4 (PMCA4) function during T cell activation resulting in sustained elevation of Ca2+ signals(Ritchie, Samakai, & Soboloff, 2012). This interaction requires upregulation of both STIM1 and PMCA4. In this thesis, I hypothesize that changes in Ca2+ signals arising from transcriptional changes of STIM1 and PMCA are important for the efficient activation of T cells. In the first part of this thesis, I assess the transcriptional regulation of STIM1 and PMCA4. My in vitro studies show that expression of both proteins is regulated by the EGR family members, EGR1 and EGR4. Additionally, transcriptional regulation of PMCA inhibition by EGR1 and EGR4 is required for efficient activation of T cells. Interestingly, whereas significant roles for EGR1, EGR2 and EGR3 in T cell development and function have been established, a role for EGR4 has not, hitherto been elucidated. In the second half of this thesis, using qPCR, I reveal that EGR4 expression is stimulated by TCR engagement in primary double positive, CD4 and CD8 positive murine T cells. Further, EGR4-null mice exhibit shifts in early thymic development, although this does not affect the relative number of double or single positive T cells in the thymus. Interestingly, EGR4-null primary T cells exhibit normal Ca2+ entry, but fail to exhibit activation-induced inhibition of Ca2+ clearance. Although not all subsets of EGR1 and EGR4 null primary T cells exhibited decreased STIM1 expression, significant defects in proliferation, migration and/or cytokine production were observed upon stimulation in all populations, albeit to different extents. These findings reveal a two-faceted role in which EGRs regulate T cell development and function through both Ca2+-dependent and independent methods. I believe that these findings have important implications towards the general understanding of transcriptional control of Ca2+ signaling, as well as having a possible impact in the quest to advance therapies targeting immunological disorders.
Temple University--Theses
Стилі APA, Harvard, Vancouver, ISO та ін.
7

Serrano, Daniel. "GIMAP5 influence la survie des cellules T naïves en participant à la régulation du calcium emmagasiné dans les organites." Thèse, Université de Sherbrooke, 2017. http://hdl.handle.net/11143/11088.

Повний текст джерела
Анотація:
La survie des cellules T naïves est essentielle au bon fonctionnement du système immunitaire à long terme. Les rats BBDP (Bio-breeding Diabetes prone) sont caractérisés par une haute prédisposition au développement du diabète ainsi que par une diminution significative du nombre de cellules T naïves. Ces rats comportent une mutation de type décalage de lecture dans le gène codant pour «GTPase Immunity-Associated Protein 5» (Gimap5) ce qui entraine l’apoptose des lymphocytes T. Le mécanisme par lequel la déficience de la protéine GIMAP5 conduit les cellules T à la mort est actuellement méconnu. GIMAP5 a également été associée à différentes maladies auto-immunes, ce qui suggère son influence dans l'homéostasie des lymphocytes T. Des résultats antérieurs de notre groupe de recherche ont montré que l'absence de GIMAP5 entraîne une diminution du flux de Ca2+ ainsi qu’une réduction de la capacité mitochondriale à emmagasiner du Ca2+ suite à la stimulation du TCR. Cependant, GIMAP5 n'est pas une protéine mitochondriale. Afin de mieux comprendre le rôle de GIMAP5 dans la biologie des cellules T, au cours de mes études doctorales, je me suis concentré sur la localisation cellulaire de la protéine ainsi que sur son rôle dans l'homéostasie du Ca2+. Comme modèle d’étude, j'ai établi des lignées cellulaires HEK293T stables pour l’expression de GIMAP5, ainsi que pour différents mutants et variantes de la protéine. Ceci m’a permis d’élucider l'importance du domaine transmembranaire (TM) pour la localisation et le rôle physiologique de GIMAP5 ainsi que la différence entre les deux variantes de cette protéine. Mes résultats ont permis de montrer que l'expression de Gimap5 ne semble pas être nécessaire après l’activation des lymphocytes T. En parallèle, j'ai confirmé nos observations antérieures qui démontrent l’influence de GIMAP5 dans l'homéostasie du Ca2+ et sa colocalization avec les microtubules. En outre, j'ai montré que GIMAP5 se trouve dans des structures de type vésiculaire, particulièrement dans la membrane lysosomale où son domaine TM est essentiel à son bon fonctionnement et localisation. Mes résultats suggèrent que les mitochondries exhibent un défaut dans leur capacité à emmagasiner du Ca2+ au niveau basal, ainsi que suite à l’activation du TCR. Enfin, j'ai démontré pour la première fois, que l'influence de GIMAP5 sur le stockage de Ca2+ lysosomal peut avoir un impact sur la survie des lymphocytes T. D’après ces observations, une des fonctions probables de GIMAP5 serait d’empêcher la fermeture prématurée des canaux de relâche calcique. Finalement, GIMAP5 pourrait être engagé dans des mécanismes visant à prolonger et raffiner la signalisation du Ca2+ dans les cellules T. Bref, la régulation du Ca2+ lysosomal médié par GIMAP5 est essentielle à la survie de cellules T naïves.
Abstract: Healthy and long-term survival of naïve T cells is essential for proper functioning of the immune system. In bio-breeding diabetes prone (BBDP) rats, there is a critical decrease in the number of naïve T cells. In these rats, a recessive frameshift mutation in the GTPase of Immune-Associated Protein 5 (Gimap5) gene induces lymphocytes to undergo spontaneous apoptosis. The death of T cells driven by a deficiency of the GIMAP5 is currently not fully understood. Interestingly, different autoimmune diseases have shown an association with perturbations in the Gimap5 gene, which further suggests its influence in basal lymphocyte homeostasis. Previous findings by our group have shown that the absence of GIMAP5 results in a decrease calcium flux following TCR stimulation and an impaired capacity of the mitochondria to buffer calcium entry. However, GIMAP5 is not a mitochondrial protein. During my Ph.D. studies, I focused on clarifying the cellular localization of GIMAP5 as well as its function in Ca2+ homeostasis in order to further understand its role in T cell biology. As a model, I established HEK293T cells stable for the expression of the different mutants and variants of the GIMAP5 protein. Where I uncovered the importance of the transmembrane domain (TM) for GIMAP5 localization and physiological role, as well as the differences between the two variants of GIMAP5. The results obtained show that the expression of Gimap5 is no longer needed after T cells activation. Moreover, our previous observations were confirmed and expanded upon regarding GIMAP5’s influence on Ca2+ homeostasis and colocalization with the cytoskeleton. It was also shown that GIMAP5 localizes to vesicular-like structures, particularly to the lysosomal membrane, where its TM domain is critical for proper functioning and localization. My results suggest that the mitochondria might be impaired to uptake as well as retain Ca2+ at their full capacity in the absence of GIMAP5. Finally, I observed for the first time that GIMAP5’s influence on lysosomal Ca2+ storage could impact lymphocyte survival. These results suggest that GIMAP5 may work as a backup mechanism to prevent premature closure of Ca2+ channels and Ca2+ influx or as a mechanism to prolong and refine Ca2+ signaling in T cells.
Стилі APA, Harvard, Vancouver, ISO та ін.
8

Li, Qince. "Mathematical modelling of intracellular Ca2+ alternans in atrial and ventricular myocytes." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/mathematical-modelling-of-intracellular-ca2-alternans-in-atrial-and-ventricular-myocytes(54ff4d2a-f820-43b6-a572-4706850f28ec).html.

Повний текст джерела
Анотація:
During excitation-contraction coupling, Ca2+ transient induced by the depolarization of membrane potential is the trigger of mechanical contraction in cardiac myocytes, which is responsible for the pumping function of the heart. However, mechanisms underlying intracellular Ca2+ regulation and the coupling between Ca2+ transient and membrane potential are not completely understood. Abnormalities in intracellular Ca2+ regulation have been observed during heart failure and cardiac arrhythmias, such as intracellular Ca2+ alternans and T-tubule disorganization. In this project, intracellular Ca2+ dynamics in different types of cardiac myocytes were investigated by using computer modelling. For atrial myocytes, a biophysically detailed computer model was developed to describe the observations of Ca2+ alternans and Ca2+ wave propagation in cardiac myocytes lacking T-tubules. The model was validated by its ability to reproduce experimental observed Ca2+ wave propagation under normal condition and the influences on spatial Ca2+ distribution by modifying various aspects of Ca2+ cycling, such as Ca2+ influx, SR Ca2+ uptake and SR Ca2+ release in cardiac myocytes lacking T-tubules. Mechanisms underlying the genesis of Ca2+ alternans in this type of cell were investigated by the model. Furthermore, a spontaneous second Ca2+ release was observed in response to a single voltage stimulus pulse with enhanced Ca2+ influx as well as SR Ca2+ overload. For the ventricular myocytes, an existing canine model was used to study the genesis of APD and intracellular Ca2+ alternans under various conditions. The genesis of Ca2+ alternans was investigated by analyzing the relationship between systolic Ca2+ concentration and SR Ca2+ content. On the other side, the roles of SR Ca2+ regulation and action potential restitution in the genesis of intracellular Ca2+ and APD alternans were also examined under various conditions. In addition, it was shown that spatially discordant Ca2+ alternans was generated when the Ca2+-dependent inactivation of ICa,L was strong. It tended to be concordant for weak Ca2+-dependent inactivation of ICa,L. For the sinoatrial node cells, a mathematical model was developed to simulate stochastic opening of unitary L-type Ca2+ channel and single RyR channel, thereby reproducing experimental observed local Ca2+ release during diastolic depolarization phase of the action potential. Simulation results of ionic channel block and modifications of SR Ca2+ regulation suggested a limited role of intracellular Ca2+ in the automaticity of central SA node cells.
Стилі APA, Harvard, Vancouver, ISO та ін.
9

Malik, Aqsa. "Functional characterization of T-type calcium channels in area CA3 of the hippocampus." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/55100.

Повний текст джерела
Анотація:
Calcium (Ca²+) entry through voltage-gated Ca²+ channels in dendrites of hippocampal pyramidal cells (PCs) contributes to synaptic depolarization and activation of downstream pathways that regulate many aspects of synaptic and cellular function. Activated by small depolarizing changes in voltage, T-type Ca²+ channels mediate low-threshold spikes (LTS) that drive the resting membrane potential towards action potential threshold. T-type Ca²+ channels are hypothesized to contribute to subthreshold synaptic depolarization in the CA3 subfield of the hippocampus due to the stratified nature of inputs on CA3 dendrites. While T-type Ca²+ channels are densely expressed in area CA3, their functional characteristics and interactions with postsynaptic receptors are not well understood and LTS have not been reported in CA3 PCs. In Chapter 3, using whole-cell electrophysiology, we demonstrate that LTS in CA3 PCs can be evoked by somatic current injection. LTS were only evoked when 4AP was applied to depress A-type K+ channels. Using specific pharmacological blockers, we show that Cav3.2 channels mediate LTS in CA1 and CA3 PCs. In Chapter 4, using two-photon Ca²+ imaging, we map the subcellular distribution of Cav3.2 channels in hippocampal PCs. Our results show that Cav3.2 channel expression is restricted to the soma and proximal dendrites in CA1 PCs, while Ca²+ influx from Cav3.2 channel activation occurs in distal (>50 μm) regions of CA3 PC dendrites. In Chapter 5, we demonstrate that mAChR stimulation potentiates LTS amplitude and such amplification of Ca²+ influx through Cav3.2 channels is dependent on M-current inhibition. Furthermore, we show that application of t-ACPD causes potent and rapid inhibition of LTS propagation. This inhibition occurs exclusively through mGlu₁ receptors and downstream activation of PKC is necessary for this process. Lastly, in Chapter 6, we show boosting of subthreshold synaptic signals by T-type Ca²+ channels in PCs within area CA3 but not CA1. Taken together, our data identify a new T-type mediated Ca²+ signaling pathway in CA3 PC dendrites that is unlocked by A-type K+ channel blockade, potentiated by mAChR activation, and inhibited by mGluR₁ activation. Furthermore, our study highlights the important involvement of T-type Ca²+ channels in enhancing dendritic depolarization in CA3 PCs.
Medicine, Faculty of
Graduate
Стилі APA, Harvard, Vancouver, ISO та ін.
10

Kinoshita, Hideyuki. "T-Type Ca2+ Channel Blockade Prevents Sudden Death in Mice With Heart Failure." Kyoto University, 2010. http://hdl.handle.net/2433/120614.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
Більше джерел

Книги з теми "T-CAD"

1

Orla, Nic Ruairí, ed. Cad é an t-am atá sé? [Belfast]: Bunscoil Phobal Feirste, 1992.

Знайти повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
2

Dreyfus, Hubert L. What computers still can`t do. Cambridge; London: The MIT press, 1997.

Знайти повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
3

ng, Long Tu. Bo ng nguoi xua: Tie u thuye t ti nh cam. [Glendale, Calif.]: [♯ai Nam], 1989.

Знайти повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
4

Anderson, Harry. Harry Anderson s gamesyou can t lose: A guide for suckers. New York: Pocket Books, 1989.

Знайти повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
5

CAD/CAM in D & T. King's Lynn: Leicestershire CITB Curriculum Project, 1993.

Знайти повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
6

Jha, Sachidanand. T-FLEX CAD Exercises: 200 3D Practice Drawings for T-FLEX CAD and Other Feature-Based 3D Modeling Software. Independently Published, 2019.

Знайти повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
7

CAD Monkeys, Dinosaur Babies and T-Shaped People. Penguin, 2010.

Знайти повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
8

Blakeley, Kiri. Can T Think Straight. Kensington Publishing Corporation, 2011.

Знайти повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
9

Schlegel, Anna, and Schlegel Press Association. Money Can`t Lie. Schlegel Press Association, 2016.

Знайти повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
10

Association, Schlegel Press, and Anna Sсhlegel. Money Can`t Lie. Schlegel Press Association, 2016.

Знайти повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
Більше джерел

Частини книг з теми "T-CAD"

1

Lloyd, P., C. C. McAndrew, M. J. McLennan, S. Nassif, K. Singhal, Ku Singhal, P. M. Zeitzoff, et al. "Technology CAD at AT&T." In Technology CAD Systems, 1–24. Vienna: Springer Vienna, 1993. http://dx.doi.org/10.1007/978-3-7091-9315-0_1.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
2

Srivastava, Ajay Kumar. "T-CAD Simulation for the Designing of Detectors." In Si Detectors and Characterization for HEP and Photon Science Experiment, 63–72. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-19531-1_5.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
3

Schwaiger, Leo. "T." In CAD-Begriffe, 234–40. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-93354-7_22.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
4

Avola, Danilo, Luigi Cinque, and Marco Di Girolamo. "A Novel T-CAD Framework to Support Medical Image Analysis and Reconstruction." In Image Analysis and Processing – ICIAP 2011, 414–23. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-24088-1_43.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
5

Deepika, P., E. Subhasri, and Sanjoy Deb. "T-CAD Design Simulation and Comparative Performance Analysis of 6-T SRAM Cell with Nanoscale SOI and MOS Technology." In Physics of Semiconductor Devices, 21–23. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03002-9_6.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
6

Hell, Walter, and Max Neumeier. "CAD-Anwendung im Entwicklungsbereich eines Automobilunternehmens -Inhalte und Konsequenzen eines A+T-Projektes —." In Software für die Arbeit von morgen, 337–44. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76345-8_29.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
7

Merayo, Mercedes G., Manuel Núñez, and Ismael Rodríguez. "${\cal T}\! {\cal H} {\cal O} {\cal T}\! {\cal L}$ : A Timed Extension of ${\cal H} {\cal O} {\cal T}\! {\cal L}$." In Testing of Software and Communicating Systems, 86–102. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-68524-1_8.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
8

Noetscher, Gregory, Peter Serano, Ara Nazarian, and Sergey Makarov. "Computational Tool Comprising Visible Human Project® Based Anatomical Female CAD Model and Ansys HFSS/Mechanical® FEM Software for Temperature Rise Prediction Near an Orthopedic Femoral Nail Implant During a 1.5 T MRI Scan." In Brain and Human Body Modelling 2021, 133–51. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-15451-5_9.

Повний текст джерела
Анотація:
AbstractThis medical device development tool (MDDT) is categorized as a non-clinical assessment model (NAM). This MDDT is a computational modeling and simulation tool. It can predict heating of metallic orthopedic implants with the radio frequency (RF) electromagnetic fields in the magnetic resonance imaging (MRI) coils while targeting a mid-aged and elderly female population primarily affected by osteoporosis and the associated bone fracture.This MDDT uses a high resolution anatomical female CAD (computer aided design) model coupled with the proven multiphysics finite element method (FEM) software (Ansys Workbench) to simulate the complete MRI environment. The environment is consisting of a tuned MRI coil with the given output power, detailed heterogeneous human model within the coil at the given landmark and a properly embedded metallic implant within the anatomical model to compute the extent of heating generated around the implant.Specifically, this MDDT is the in silico analog of an MRI scan for an elderly female subject with a metallic orthopedic implant at 1.5 T in a full-body birdcage RF coil.
Стилі APA, Harvard, Vancouver, ISO та ін.
9

Berger, Susanna Carolina, Boris Fehse, and Marie-Thérèse Rubio. "Immune Monitoring." In The EBMT/EHA CAR-T Cell Handbook, 177–82. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-94353-0_35.

Повний текст джерела
Анотація:
AbstractCAR-T cell expansion and persistence are critical parameters for therapeutic efficacy and toxicity (Locke et al. 2020). However, CAR-T cells are patient-specific ‘living drugs’ with an unpredictable ability to expand in vivo. Thus, close postinfusion monitoring should be a major prerequisite to better manage this therapy. Critical parameters include CAR-T cell expansion kinetics and phenotype immune reconstitution and serum biomarkers (Fig. 35.1; Kalos et al. 2011; Hu and Huang 2020). Additionally, prospective collection and storage of patient specimens should be planned for future hypothesis-driven studies at specialized research centres. To date, despite the rapid expansion of CAR-T cell therapy, no standard recommendations exist for CAR monitoring, and harmonization of efforts across multiple centres is urgently needed.
Стилі APA, Harvard, Vancouver, ISO та ін.
10

Abou-el-Enein, Mohamed, and Jordan Gauthier. "The Value of CAR-T-cell Immunotherapy in Cancer." In The EBMT/EHA CAR-T Cell Handbook, 231–34. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-94353-0_46.

Повний текст джерела
Анотація:
AbstractThe development of genetically modified chimeric antigen receptor (CAR) T-cells to target cancer by conferring tumour antigen recognition has tremendously improved the fight against the disease and broadened treatment options for haematological malignancies (Elsallab et al. 2020b). However, in contrast to conventional drugs that patients can easily access, the implementation of CAR-T-cell therapy in routine clinical practice poses significant challenges. Access to CAR-T-cell products is currently limited to specific certified centres meeting the requirements set up by manufacturers and regulatory agencies. There are also issues regarding insurance coverage, reimbursement, affordability, and pricing, which have critical impacts on broadening patient access to these novel therapies (Abou-El-Enein et al. 2016a, b). Current list pricing ranges between $373,000 and $475,000 per one-time infusion for the four CAR-T-cell therapies currently approved by the FDA (tisagenlecleucel, Kymriah®; axicabtagene ciloleucel, Yescarta®; brexucabtagene autoleucel, Tecartus®; lisocabtagene maraleucel, Breyanzi®). In addition to the cost of the CAR-T-cell product, patient preparation (leukapheresis and/or lymphodepletion), product infusion, pre- and post-infusion patient management, and monitoring for side effects (Wagner et al. 2021) significantly add to the final price tag. There are calls for restructuring the current payment and reimbursement models to allow better access to CAR-T-cell therapies (Abou-El-Enein et al. 2014). However, this would only be possible after examining the strength of clinical evidence generated during product development (Abou-El-Enein and Hey 2019; Elsallab et al. 2020a) and, most importantly, by determining the value of CAR-T-cell therapy.
Стилі APA, Harvard, Vancouver, ISO та ін.

Тези доповідей конференцій з теми "T-CAD"

1

Liu, ShiXu, Amar Deshamudre, Allan Spence, Maneesh Khanna, and Aaron Guo. "A Modular CAD Based GD&T Workflow for CNC Machining and Inspection." In CAD'17. CAD Solutions LLC, 2017. http://dx.doi.org/10.14733/cadconfp.2017.76-80.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
2

Chen, Yet-Min, Yu-Sheng Chen, Jian-Jang Huang, Jiun-Haw Lee, Yu-Wu Wang, and Yi-Kai Wang. "Analytical and T-CAD modeling of pentacene thin-film transistors." In SPIE Optics + Photonics, edited by Zhenan Bao and David J. Gundlach. SPIE, 2006. http://dx.doi.org/10.1117/12.679748.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
3

Milvovzorov, O. V., and N. V. Gribov. "Mini-CAD 3-D Modellings of Multistage Shaftson the Basis of the T-FLEX CAD 3D System." In 32nd International Conference on Computer Graphics and Vision. Keldysh Institute of Applied Mathematics, 2022. http://dx.doi.org/10.20948/graphicon-2022-1050-1058.

Повний текст джерела
Анотація:
A system for semi-automatic design of 3D models of machine-building parts of the "body of revolution" type - multi-stage shafts, made on the basis of the domestic software complex of threedimensional solid modeling T-Flex CAD 3D, is being considered. Such systems can be classified as mini-CAD. This mini CAD provides automatic formation of 3D models of multi-stage shafts, the design of which can include up to seven stages, grooves for the exit of the grinding wheel, chamfers and key grooves. The principles of forming a 3D model of a complex multi-stage part, its system of parameters, and features of geometric constructions are described. This model includes the entire possible set of structural elements, while the 3D model of a specific design of the shaft is implemented by excluding unnecessary steps and structural elements from this model and assigning specific dimensional parameters to the remaining elements. To simplify the process of entering a description of a specific version of the shaft, a user interface is introduced in the mini-CAD.
Стилі APA, Harvard, Vancouver, ISO та ін.
4

Pütz, Claus, and Frank Schmitt. "HIGH INTENSITY LEARNING OF CAD EMPOWERED BY A SIX-T-SYSTEM." In 21st International Conference on Engineering and Product Design Education. The Design Society, 2019. http://dx.doi.org/10.35199/epde2019.56.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
5

Cerantonio, Viviana, Marcello Giuffrida, Cristina Miccoli, Alessandro Chini, and Ferdinando Iucolano. "From T-CAD simulations to large signal model for GaN RF device." In 2020 AEIT International Conference of Electrical and Electronic Technologies for Automotive (AEIT AUTOMOTIVE). IEEE, 2020. http://dx.doi.org/10.23919/aeitautomotive50086.2020.9307389.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
6

Herrman, Marissa, Taylor Barca, Xue (Cher) Yang, Maryam Tabrizizad, Morgan Smith-Boeck, Louise Kiru, Jonathan Wong та ін. "198 Innate-enhanced chimeric adaptors (CAd): A newly-described approach for augmenting potency of γδ T cell immunotherapy". У SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.0198.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
7

Yamaguchi, Y., K. Hayashi, T. Oishi, H. Otsuka, K. Yamanaka, M. Nakayama, and Y. Miyamoto. "Analysis on trade-off between electric field and gate-drain capacitance for GaN HEMT by T-CAD simulation." In 2012 International Conference on Solid State Devices and Materials. The Japan Society of Applied Physics, 2012. http://dx.doi.org/10.7567/ssdm.2012.ps-6-21.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
8

Miccoli, Cristina, Viviana Cerantonio, Alessandro Chini, and Ferdinando Iucolano. "T-CAD simulations study on drain leakage current and its correlation with gate current for AlGaN/GaN HEMTs." In 2021 IEEE 8th Workshop on Wide Bandgap Power Devices and Applications (WiPDA). IEEE, 2021. http://dx.doi.org/10.1109/wipda49284.2021.9645150.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
9

Tartarin, J. G., D. Saugnon, O. Lazar, G. Maillot, and L. Bary. "Understanding traps locations and impact on AlGaN/GaN HEMT by LFN noise & transient measurements, and T-CAD simulations." In 2017 International Conference on Noise and Fluctuations (ICNF). IEEE, 2017. http://dx.doi.org/10.1109/icnf.2017.7985988.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
10

Wearring, Colin. "The Functional Feature Model: Bridging the CAD/CAM Gap." In ASME 1996 Design Engineering Technical Conferences and Computers in Engineering Conference. American Society of Mechanical Engineers, 1996. http://dx.doi.org/10.1115/96-detc/cie-1653.

Повний текст джерела
Анотація:
Abstract Commercial CAD systems were originally developed to support the generation of 2D engineering drawings, but evolved to support development of 3D product models. Conceptually, the product model replaces 2D engineering drawings as a means for communicating product information such as size, shape, features, datums, tolerances, and other engineering specifications. Because of their history, the software architecture and data models used by commercial CAD systems do not directly represent all the engineering product information contained in 2D engineering drawings. Computer Assisted Engineering (CAE) tools require engineering product specifications as input. When these tools are integrated directly with the CAD system, a database representation of the product model is required for their efficient operation. Without a direct link to the CAD system, information must be transferred using standard format files, or manually entered into the CAE application. To satisfy the requirements for direct integration of CAE applications with CAD systems, the Functional Feature Model (FFM) was developed. By definition, the Functional Feature Model (FFM) contains component geometry, feature definitions, datums, datum features, tolerances and other feature attributes accessed through a standard interface. The FFM was named to distinguish the functional features used by an engineer in the definition of part function, inspection, and assembly from the features employed by CAD systems in construction of geometry. Today, the FFM is used as the basis for CAE tools which perform analysis of product Geometric Dimensioning and Tolerancing (GD&T), 3D tolerance analysis of assemblies, and CMM programming. Any CAE application which requires the same or similar information as these applications can obtain its input from the FFM. The FFM is a mature, commercially proven prototype for a standard product model, containing the majority of engineering product information typically represented using 2D drawings annotated with Geometric Dimensional and Tolerancing (GD&T) symbols. The FFM can be used instead of 2D drawings to supply necessary product information to CAE applications. Using the FFM, there is no need to create the 2D engineering drawing, interpret the GD&T annotation, and enter the interpreted product information into the CAE application. It provides a standard interface (independent of CAD system) for commercial development of CAE applications, and is designed in a fashion which makes it appropriate for use as a basis for emerging product model standards. The FFM provides a prototype for related activities like the Standard for the Exchange of Product Model Data (STEP) initiative represented by the Product Data Exchange using STEP (PDES) organization in the USA. Corporate and government consortiums such as the Rapid Response Manufacturing (RRM) or Simulation Assessment Validation Environment (SAVE) initiatives could employ the FFM directly to support their objectives of developing the next generation design and simulation environment.
Стилі APA, Harvard, Vancouver, ISO та ін.

Звіти організацій з теми "T-CAD"

1

Nelson, W. D., ed. MFTF-. cap alpha. + T progress report. Office of Scientific and Technical Information (OSTI), April 1985. http://dx.doi.org/10.2172/5883464.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
2

Kleefeldt, K. Fusion blanket testing in MFTF-. cap alpha. + T. Office of Scientific and Technical Information (OSTI), January 1985. http://dx.doi.org/10.2172/5581297.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
3

Balliett, Timothy D. Investigation of Cast Austempered Ductile Iron (CADI) Trackshoes in T- 158 Configuration. Fort Belvoir, VA: Defense Technical Information Center, January 1992. http://dx.doi.org/10.21236/ada262436.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
4

Baader, Franz, and Oliver Fernández Gil. Decidability and Complexity of Threshold Description Logics Induced by Concept Similarity Measures. Technische Universität Dresden, 2016. http://dx.doi.org/10.25368/2022.229.

Повний текст джерела
Анотація:
In a recent research paper, we have proposed an extension of the lightweight Description Logic (DL) EL in which concepts can be defined in an approximate way. To this purpose, the notion of a graded membership function m, which instead of a Boolean membership value 0 or 1 yields a membership degree from the interval [0; 1], was introduced. Threshold concepts can then, for example, require that an individual belongs to a concept C with degree at least 0:8. Reasoning in the threshold DL T EL(m) obtained this way of course depends on the employed graded membership function m. The paper defines a specific such function, called deg, and determines the exact complexity of reasoning in T EL(deg). In addition, it shows how concept similarity measures (CSMs) ~ satisfying certain properties can be used to define graded membership functions m~, but it does not investigate the complexity of reasoning in the induced threshold DLs T EL(m~). In the present paper, we start filling this gap. In particular, we show that computability of ~ implies decidability of T EL(m~), and we introduce a class of CSMs for which reasoning in the induced threshold DLs has the same complexity as in T EL(deg).
Стилі APA, Harvard, Vancouver, ISO та ін.
5

Young, Ron, ed. Knowledge Management: Tools and Techniques Manual. Asian Productivity Organization, February 2020. http://dx.doi.org/10.61145/coee1851.

Повний текст джерела
Анотація:
After publication of the APO’s Knowledge Management Tools and Techniques (KMT&T) in 2010, information access expanded dramatically, the ISO 30401 Knowledge Management Standard was issued, and KM approaches to productivity gains evolved. The revised KMT&T reflects those changes. It explains the top 20 tools for starting KM; contains current website references, video links, and document templates; and answers FAQs on KM practices. The new edition of KMT&T shows how productivity-focused KM can benefit all types and sizes of enterprises today.
Стилі APA, Harvard, Vancouver, ISO та ін.
6

Perelson, Alan S., and Robertus de Boer. Antigen-stimulated CD4 T cell expansion can be limited by their grazing of peptide-MHC complexes. Office of Scientific and Technical Information (OSTI), December 2012. http://dx.doi.org/10.2172/1058057.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
7

Chapman and Keshavarz-Valian. L51988 Development of Turbocharger-Reciprocating Engine Simulation (T-RECS). Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), December 2002. http://dx.doi.org/10.55274/r0010947.

Повний текст джерела
Анотація:
The objective of this project was to develop a numerical simulation system that can be used to optimize the performance of a large-bore reciprocating engine. The simulation system will include sub-models of all major components between the inlet filter and the exhaust pipe of the engine. The deliverable product of this project is the software program, Turbocharger-Reciprocating Engine Computer Simulation (T-RECS), which was developed at the National Gas Machinery Laboratory at Kansas State University. The simulation program calls upon a database of system components to allow the user specify a specific system. The database in this edition of T-RECS contains nominal components, but will be expanded under the Populate T-RECS project that has been funded by the Gas Research Institute. This report contains 1) a discussion of the methodology utilized to develop T-RECS; 2) a user�s guide; and 3) an example problem.
Стилі APA, Harvard, Vancouver, ISO та ін.
8

Tzfira, Tzvi, Michael Elbaum, and Sharon Wolf. DNA transfer by Agrobacterium: a cooperative interaction of ssDNA, virulence proteins, and plant host factors. United States Department of Agriculture, December 2005. http://dx.doi.org/10.32747/2005.7695881.bard.

Повний текст джерела
Анотація:
Agrobacteriumtumefaciensmediates genetic transformation of plants. The possibility of exchanging the natural genes for other DNA has led to Agrobacterium’s emergence as the primary vector for genetic modification of plants. The similarity among eukaryotic mechanisms of nuclear import also suggests use of its active elements as media for non-viral genetic therapy in animals. These considerations motivate the present study of the process that carries DNA of bacterial origin into the host nucleus. The infective pathway of Agrobacterium involves excision of a single-stranded DNA molecule (T-strand) from the bacterial tumor-inducing plasmid. This transferred DNA (T-DNA) travels to the host cell cytoplasm along with two virulence proteins, VirD2 and VirE2, through a specific bacteriumplant channel(s). Little is known about the precise structure and composition of the resulting complex within the host cell and even less is known about the mechanism of its nuclear import and integration into the host cell genome. In the present proposal we combined the expertise of the US and Israeli labs and revealed many of the biophysical and biological properties of the genetic transformation process, thus enhancing our understanding of the processes leading to nuclear import and integration of the Agrobacterium T-DNA. Specifically, we sought to: I. Elucidate the interaction of the T-strand with its chaperones. II. Analyzing the three-dimensional structure of the T-complex and its chaperones in vitro. III. Analyze kinetics of T-complex formation and T-complex nuclear import. During the past three years we accomplished our goals and made the following major discoveries: (1) Resolved the VirE2-ssDNA three-dimensional structure. (2) Characterized VirE2-ssDNA assembly and aggregation, along with regulation by VirE1. (3) Studied VirE2-ssDNA nuclear import by electron tomography. (4) Showed that T-DNA integrates via double-stranded (ds) intermediates. (5) Identified that Arabidopsis Ku80 interacts with dsT-DNA intermediates and is essential for T-DNA integration. (6) Found a role of targeted proteolysis in T-DNA uncoating. Our research provide significant physical, molecular, and structural insights into the Tcomplex structure and composition, the effect of host receptors on its nuclear import, the mechanism of T-DNA nuclear import, proteolysis and integration in host cells. Understanding the mechanical and molecular basis for T-DNA nuclear import and integration is an essential key for the development of new strategies for genetic transformation of recalcitrant plant species. Thus, the knowledge gained in this study can potentially be applied to enhance the transformation process by interfering with key steps of the transformation process (i.e. nuclear import, proteolysis and integration). Finally, in addition to the study of Agrobacterium-host interaction, our research also revealed some fundamental insights into basic cellular mechanisms of nuclear import, targeted proteolysis, protein-DNA interactions and DNA repair.
Стилі APA, Harvard, Vancouver, ISO та ін.
9

León Pacheco,, R., A. Orozco Guerreo, G. Silva Acosta, J. Gomez Correa, and E. Rosero Alpala. Efecto de las condiciones edafoclimáticas sobre variedades promisorias de yuca biofortificadas durante dos épocas de siembra. Corporación colombiana de investigación agropecuaria - AGROSAVIA, 2019. http://dx.doi.org/10.21930/agrosavia.poster.2019.1.

Повний текст джерела
Анотація:
A nivel global la yuca (Manihot esculenta Crantz) es considerada como un producto básico para la alimentación de más de mil millones de personas (FAOSTAT, 2018). La producción más importante de este cultivo en Colombia proviene de los ambientes semiáridos de la región Caribe, con un rendimiento promedio de 10.2 t/ha, considerado bajo respecto a otras regiones donde se llega a producir hasta 17 t/ha (DANE 2016; MADR, 2016). Se han identi cado brechas tecnológicas en cuanto a la importancia de mejorar los rendimientos para consumo en fresco y la generación de valor agregado, además de contribuir a la generación de sistemas productivos resilientes, capaces de adaptarse a las principales limitantes bióticas y abióticas, propias de esta región. En ese sentido, el objetivo fue identi car las condiciones climáticas más limitantes en el comportamiento de genotipos bioforti cados de yuca, introducidos por el CIAT, bajo las condiciones agroclimáticas de la región Caribe de Colombia.
Стилі APA, Harvard, Vancouver, ISO та ін.
10

Zhao, Kangjia, Jiwen Sun, Nanping Shen, Mengxue He, Haishan Ruan, Geng Lin, Jiali Ma, and Yanhua Xu. Treatment-Related Adverse Events of Chimeric Antigen receptor T-Cell (CAR-T) Cell Therapy in B-cell hematological malignancies in the Pediatric and Young Adult Population: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2022. http://dx.doi.org/10.37766/inplasy2022.7.0034.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
Також вас можуть зацікавити розширені добірки на тему "T-CAD" для конкретних типів джерел:
Статті в журналах Дисертації Книги
Ми пропонуємо знижки на всі преміум-плани для авторів, чиї праці увійшли до тематичних добірок літератури. Зв'яжіться з нами, щоб отримати унікальний промокод!

До бібліографії