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Готові списки джерел за темами / System radiobiology

Добірка наукової літератури з теми "System radiobiology"

Автор: Grafiati

Опубліковано: 11 березня 2023

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Статті в журналах з теми "System radiobiology"

1

Baverstock, K., and H. Nikjoo. "Can a system approach help radiobiology?" Radiation Protection Dosimetry 143, no. 2-4 (December 15, 2010): 536–41. http://dx.doi.org/10.1093/rpd/ncq467.

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2

Kobayashi, K., N. Usami, K. Hieda, K. Takakura, H. Maezawa, and T. Hayashi. "Development of microbeam irradiation system for radiobiology." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 467-468 (July 2001): 1329–32. http://dx.doi.org/10.1016/s0168-9002(01)00659-3.

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3

Kobayashi, K., N. Usami, H. Maezawa, T. Hayashi, K. Hieda, and K. Takakura. "Synchrotron X-Ray Microbeam Irradiation System for Radiobiology." Journal of Biomedical Nanotechnology 2, no. 2 (August 1, 2006): 116–19. http://dx.doi.org/10.1166/jbn.2006.020.

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4

Santacroce, Antonio, Marcel A. Kamp, Wilfried Budach, and Daniel Hänggi. "Radiobiology of Radiosurgery for the Central Nervous System." BioMed Research International 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/362761.

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According to Leksell radiosurgery is defined as “the delivery of a single, high dose of irradiation to a small and critically located intracranial volume through the intact skull.” Before its birth in the early 60s and its introduction in clinical therapeutic protocols in late the 80s dose application in radiation therapy of the brain for benign and malignant lesions was based on the administration of cumulative dose into a variable number of fractions. The rationale of dose fractionation is to lessen the risk of injury of normal tissue surrounding the target volume. Radiobiological studies of cell culture lines of malignant tumors and clinical experience with patients treated with conventional fractionated radiotherapy helped establishing this radiobiological principle. Radiosurgery provides a single high dose of radiation which translates into a specific toxic radiobiological response. Radiobiological investigations to study the effect of high dose focused radiation on the central nervous system began in late the 50s. It is well known currently that radiobiological principles applied for dose fractionation are not reproducible when single high dose of ionizing radiation is delivered. A review of the literature about radiobiology of radiosurgery for the central nervous system is presented.

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5

Kobayashi, Katsumi, Noriko Usami, Hiroshi Maezawa, Tohru Hayashi, Kotaro Hieda, and Kaoru Takakura. "Development of photon microbeam irradiation system for radiobiology." International Congress Series 1258 (November 2003): 207–11. http://dx.doi.org/10.1016/s0531-5131(03)01213-5.

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6

Pollycove, Myron, and Ludwig E. Feinendegen. "Low-dose radioimmuno-therapy of cancer." Human & Experimental Toxicology 27, no. 2 (February 2008): 169–75. http://dx.doi.org/10.1177/0960327107083411.

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Four decades of genomic, cellular, animal and human data have shown that low-dose ionizing radiation stimulates positive genomic and cellular responses associated with effective cancer prevention and therapy and increased life span of mammals and humans. 1—8 Nevertheless, this data is questioned because it seems to contradict the well demonstrated linear relation between ionizing radiation dose and damage to DNA without providing a clear mechanistic explanation of how low-dose radiation could produce such beneficial effects. This apparent contradiction is dispelled by current radiobiology that now includes DNA damage both from ionizing radiation and from endogenous metabolic free radicals, and coupled with the biological response to low-dose radiation. Acceptance of current radiobiology would invalidate long established recommendations and regulations of worldwide radiation safety organizations and so destroy the basis of the very expensive existing system of regulation and remediation. More importantly, current radiobiology would facilitate urgently needed clinical trials of low dose radiation (LDR) cancer therapy.

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7

Inkret, W. C., Y. Eisen, W. F. Harvey, A. M. Koehler та M. R. Raju. "Radiobiology of α Particles: I. Exposure System and Dosimetry". Radiation Research 123, № 3 (вересень 1990): 304. http://dx.doi.org/10.2307/3577737.

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8

Usami, N., K. Kobayashi, K. Eguchi-Kasai, H. Maezawa, K. Takakura, K. Hieda, and T. Hayashi. "3P294 Development of synchrotron X-ray microbeam irradiation system for radiobiology." Seibutsu Butsuri 45, supplement (2005): S277. http://dx.doi.org/10.2142/biophys.45.s277_2.

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9

Jagannathan, Jay, Jonathan H. Sherman, Gautam U. Mehta, and Lawrence S. Chin. "Radiobiology of brain metastasis: applications in stereotactic radiosurgery." Neurosurgical Focus 22, no. 3 (March 2007): 1–5. http://dx.doi.org/10.3171/foc.2007.22.3.5.

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✓Stereotactic radiosurgery is a neurosurgical modality in which a target lesion can be irradiated while sparing normal brain tissue. In some respects, brain metastasis is well suited for radiosurgery, as metastatic lesions tend to be small and well circumscribed and displace (but do not infiltrate) normal brain tissue, facilitating the delivery of radiation. Advances in stereotactic radiosurgical planning, such as blocking patterns and beam shaping, have allowed further targeting of discrete lesions while minimizing the effect of radiation toxicity on the central nervous system. In this paper the authors review the radiobiology of brain metastases and stereotactic radiosurgical approaches that can be used to treat these tumors safely.

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10

Willey, C. "SP-0348 Patient-derived xenografts as a model system for radiobiology research." Radiotherapy and Oncology 161 (August 2021): S254—S255. http://dx.doi.org/10.1016/s0167-8140(21)08565-0.

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Дисертації з теми "System radiobiology"

1

Morrey, D. "Aspects of computer automation in radiotherapy : A system for prescription, calculation, verification and recording of radiotherapy treatments." Thesis, Bucks New University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376420.

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2

Hall, David Jonathan. "The development of a near infrared time resolved imaging system and the assessment of the methodology for breast imaging." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243779.

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3

De, Marzi Ludovic. "Effets physiques et biologiques des faisceaux de protons balayés : mesures et modélisation pour des balayages séquentiels à haut débit." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS546/document.

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L'objectif principal de cette thèse est de développer et optimiser les algorithmes caractérisant les propriétés physiques et biologiques des mini-faisceaux de protons pour la réalisation des traitements avec modulation d'intensité. Un modèle basé sur la superposition et décomposition des mini-faisceaux en faisceaux élémentaires a été utilisé. Un nouveau modèle de description des mini-faisceaux primaires a été développé à partir de la sommation de trois fonctions gaussiennes. Les algorithmes ont été intégrés dans un logiciel de planification de traitement, puis validés expérimentalement et par comparaison avec des simulations Monte Carlo. Des approximations ont été réalisées et validées afin de réduire les temps de calcul en vue d'une utilisation clinique. Dans un deuxième temps, un travail en collaboration avec les équipes de radiobiologie de l'institut Curie a été réalisé afin d'introduire des résultats radiobiologiques dans l'optimisation biologique des plans de traitement. En effet, les faisceaux balayés sont délivrés avec des débits de dose très élevés (de 10 à 100 Gy/s) et de façon discontinue, et l'efficacité biologique des protons est encore relativement méconnue vue la diversité d'utilisation de ces faisceaux : les différents modèles disponibles et notamment leur dépendance avec le transfert d'énergie linéique ont été étudiés. De bons accords (écarts inférieurs à 3 % et 2 mm) ont été obtenus entre calculs et mesures de dose. Un protocole d'expérimentation pour caractériser les effets des hauts débits pulsés a été mis en place et les premiers résultats obtenus sur une lignée cellulaire suggèrent des variations d'efficacité biologique inférieures à 10 %, avec toutefois de larges incertitudes
The main objective of this thesis is to develop and optimize algorithms for intensity modulated proton therapy, taking into account the physical and biological pencil beam properties. A model based on the summation and fluence weighted division of the pencil beams has been used. A new parameterization of the lateral dose distribution has been developed using a combination of three Gaussian functions. The algorithms have been implemented into a treatment planning system, then experimentally validated and compared with Monte Carlo simulations. Some approximations have been made and validated in order to achieve reasonable calculation times for clinical purposes. In a second phase, a collaboration with Institut Curie radiobiological teams has been started in order to implement radiobiological parameters and results into the optimization loop of the treatment planning process. Indeed, scanned pencil beams are pulsed and delivered at high dose rates (from 10 to 100 Gy/s), and the relative biological efficiency of protons is still relatively unknown given the wide diversity of use of these beams: the different models available and their dependence with linear energy transfers have been studied. A good agreement between dose calculations and measurements (deviations lower than 3 % and 2 mm) has been obtained. An experimental protocol has been set in order to qualify pulsed high dose rate effects and preliminary results obtained on one cell line suggested variations of the biological efficiency up to 10 %, though with large uncertainties

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4

Abler, Daniel Jakob Silvester. "Software architecture for capturing clinical information in hadron therapy and the design of an ion beam for radiobiology." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:c2d9cf79-7b2d-4feb-bb17-53f003a8557c.

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Hadron Therapy (HT) exploits properties of ion radiation to gain therapeutic advantages over existing photon-based forms of external radiation therapy. However, its relative superiority and cost-effectiveness have not been proven for all clinical situations. Establishing a robust evidence base for the development of best treatment practices is one of the major challenges for the field. This thesis investigates two research infrastructures for building this essential evidence. First, the thesis develops main components of a metadata-driven software architecture for the collection of clinical information and its analysis. This architecture acknowledges the diversity in the domain and supports data interoperability by sharing information models. Their compliance to common metamodels guarantees that primary data and analysis results can be interpreted outside of the immediate production context. This is a fundamental necessity for all aspects of the evidence creation process. A metamodel of data capture forms is developed with unique properties to support data collection and documentation in this architecture. The architecture's potential to support complex analysis processes is demonstrated with the help of a novel metamodel for Markov model based simulations, as used for the synthesis of evidence in health-economic assessments. The application of both metamodels is illustrated on the example of HT. Since the biological effect of particle radiation is a major source of uncertainty in HT, in its second part, this thesis undertakes first investigations towards a new research facility for bio-medical experiments with ion beams. It examines the feasibility of upgrading LEIR, an existing accelerator at the European Organisation for Nuclear Research (CERN), with a new slow extraction and investigates transport of the extracted beam to future experiments. Possible configurations for the slow-resonant extraction process are identified, and designs for horizontal and vertical beam transport lines developed. The results of these studies indicate future research directions towards a new ion beam facility for biomedical research.

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5

Dogo, Federico. "MODELS OF DNA DAMAGE, REPAIR, AND MISREPAIR." Doctoral thesis, Università degli studi di Trieste, 2015. http://hdl.handle.net/10077/10889.

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2013/2014
Within the range of the Virtual Biophysics Lab tumour growth numerical simulator, this work aims to develop a mathematical model able to describe the cell cycle desynchronization observed in the cell populations and the effects of DNA damage and repair due to ionizing radiation. Following a review of the already available models, some other original ones are proposed; one of these has been also tested on tumour cells by means of cytometry: the results of the related data analysis are not yet conclusive.
Nell'ambito del simulatore numerico di crescita tumorale Virtual Biophysics Lab, questo lavoro mira a sviluppare un modello matematico adatto a descrivere la desincronizzazione cellulare osservata nelle popolazioni cellulari e gli effetti del danno e riparazione del DNA indotti da radiazioni ionizzanti. A seguito di una recensione dei modelli già esistenti, ne vengono proposti alcuni altri originali; uno di questi è stato anche testato su cellule tumorali attraverso la citofluorimetria: i risultati della relativa analisi dati non sono ancora decisivi.
XXVII Ciclo
1983

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6

Sakhri, Mohamed. "Radiation protection of protein-A carbohydrate systems." Thesis, University of Salford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315494.

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7

Howard, Steven Paul. "The use of in vitro cell culture systems to study the radiobiology of human epithelial cells." 1991. http://catalog.hathitrust.org/api/volumes/oclc/25679330.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1991.
Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

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Книги з теми "System radiobiology"

1

McDonald, J. C. Calorimetric dose measurements and calorimetric system developed for the Armed Forces Radiobiology Research Institute. Bethesda, Md: Defense Nuclear Agency, Armed Forces Radiobiology Research Institute, 1986.

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2

Symposia, COSPAR Scientific Commission F. F2 5. Life sciences : microgravity and space radiation effects: Proceedings of the F2.6 and F2.5 Symposia of COSPAR Scientific Commission F which was held during the Thirty-Second COSPAR Scientific Assembly, Nagoya, Japan, 12-19 July, 1998. Oxford: Published for the Committee on Space Research [by] Pergamon, 2000.

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3

Kulepanov, Vladimir. Ionizing radiation in the hydrosphere. Introduction to radiobiology and radioecology of hydrobionts. ru: INFRA-M Academic Publishing LLC., 2021. http://dx.doi.org/10.12737/1014635.

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The textbook contains information about the history of the discovery and study of ionizing radiation, about the development and formation of radiobiology and radioecology. The characteristics of ionizing radiation, radiation dose units and activity are given. The effect of ionizing radiation on biological systems is described. Modern problems of radioecology are considered. Compiled taking into account the current curriculum for the specialty "Life safety in the technosphere", it includes the main provisions of radiobiology and radioecology. Meets the requirements of the federal state educational standards of higher education of the latest generation. It is intended for independent work of students, bachelors and postgraduates, it can also be used as additional material at lectures and methodological material at seminars on the courses "Ecology "and"Marine Ecology".

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4

Foton Fakutorī Kenkyūkai (2004 Kō-enerugī Kasokuki Kenkyū Kikō). Foton Fakutorī Kenkyūkai, maikurobīmu saibō shōsha sōchi o mochiita teisenryō hōshasen eikyō kenkyū ni kansuru wākushoppu: Workshop on biological effects of low dose radiation using microbeam cell irradiation systems. Tsukuba-shi: High Energy Accelerator Research Organization, 2005.

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5

Károly, Tőkési, Sulik Béla, and American Institute of Physics, eds. Radiation damage in biomolecular systems: Proceedings of the 5th international conference : (RADAM 2008), Debrecen, Hungary, 13-15 June 2008. Melville, N.Y: American Institute of Physics, 2008.

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6

R, Freeman Gordon, ed. Kinetics of nonhomogeneous processes: A practical introduction for chemists, biologists, physicists, and materials scientists. New York: Wiley, 1987.

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7

M, Wheeler R., and COSPAR Scientific Commission F, eds. Life sciences: Life support system studies-I : proceedings of the F4.6, F4.8, F4.2 and F4.9 symposia of COSPAR Scientific Commission F which was held during the thirty-first COSPAR Scientific Assembly, Birmingham, U.K., 14-21 July 1996. Oxford, [England]: Published for the Committee on Space Research [by] Pergamon, 1997.

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8

Assembly, COSPAR Scientific. Life sciences: Space flight and the central nervous system : the potential independent and synergistic effects of microgravity and radiation : proceedings of the F2.4 Symposium of COSPAR Scientific Commission F which was held during the Thirty-first COSPAR Scientific Assembly, Birmingham, U.K., 14-21 July 1996. Oxford: Published for the Committee on Space Research [by] Pergamon, 1998.

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9

Wagemakers, Alexandre. Physics of complex systems and life sciences. Kerala, India: Research Signpost, 2007.

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10

Assembly, COSPAR Scientific. Life sciences: Complex organics in space : proceedings of the F3.2 symposium of COSPAR Scientific Commission F which was held during the thirty-first COSPAR scientific assembly, Birmingham, U.K., 14-21 July 1996. Kidlington, Oxford: Published for the Committee on Space Research [by] Pergamon, 1997.

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Частини книг з теми "System radiobiology"

1

Lebow, Emily S., Marc R. Bussière, and Helen A. Shih. "Basic Radiobiology and Radiation Physics Primer." In Central Nervous System Metastases, 271–79. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-42958-4_19.

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2

van der Kogel, A. J. "The Nervous System: Radiobiology and Experimental Pathology." In Medical Radiology, 191–212. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-83416-5_6.

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3

Chankova, Stefka G., and Nadezhda Yurina. "Micro-algae as a Model System for Studying of Genotype Resistance to Oxidative Stress and Adaptive Response." In Radiobiology and Environmental Security, 19–30. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-1939-2_3.

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4

Harryman, William L., and Anne E. Cress. "Basic Principles of Radiobiology and Cancer Metastasis Prevention." In Cancer Metastasis Through the Lymphovascular System, 653–60. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-93084-4_62.

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5

Averyn, Viktar S. "Short Refresher of Radiobiology." In Nuclear and Radiological Emergencies in Animal Production Systems, Preparedness, Response and Recovery, 13–27. Berlin, Heidelberg: Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-63021-1_2.

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AbstractThe atoms are built up of a nucleus, containing positive (protons) and neutral (neutrons) particles, surrounded by negative particles (electrons), circulating around the “atomic orbit”. The number of the protons in the nucleus is giving the atomic number of the element (usually labelled as “Z”), and the sum of the neutrons and protons in the nucleus is giving the atomic or mass number of the element (usually labelled as “A”). The number in the electrons in the atomic orbit is always equal to the number of protons in the nucleus. However, as the mass of the electrons is almost equal to zero, they do not influence the whole atomic mass.

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6

Yakovlev, Andrej Yu, and Aleksandr V. Zorin. "Simulation of Controlled Cell Systems." In Computer Simulation in Cell Radiobiology, 97–113. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-51716-7_5.

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7

MONROY, RODNEY L. "Radiation Effects on the Lymphohematopoietic System: A Compromise in Immune Competency." In Military Radiobiology, 111–34. Elsevier, 1987. http://dx.doi.org/10.1016/b978-0-12-184050-1.50008-x.

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8

Prasad, Kedar N. "Radiation Damage of the Nervous System." In Handbook of RADIOBIOLOGY, 161–70. CRC Press, 2020. http://dx.doi.org/10.1201/9781003067825-10.

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9

Prasad, Kedar N. "Radiation Damage of the Nervous System." In Handbook of RADIOBIOLOGY, 161–70. CRC Press, 2020. http://dx.doi.org/10.4324/9781003067825-10.

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10

"13 Radiobiology of the Central Nervous System." In Neuro-oncology: The Essentials, edited by Mark Bernstein and Mitchel S. Berger. Stuttgart: Georg Thieme Verlag, 2008. http://dx.doi.org/10.1055/b-0034-63638.

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Тези доповідей конференцій з теми "System radiobiology"

1

Lee, Hanna, Jinho Choi, Amar Prasad Gupta, Jaeik Jung, Jaekyu Jang, Moonkyoo Kong, Yeong Heum Yeon, et al. "Design of CNT-based electron microbeam cell irradiation system for low-dose radiobiology research." In Physics of Medical Imaging, edited by Wei Zhao and Lifeng Yu. SPIE, 2022. http://dx.doi.org/10.1117/12.2613347.

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2

Morozova, T. V., and L. V. Pokhodzey. "PROMISING DIRECTIONS OF SCIENTIFIC AND PEDAGOGICAL WORK OF THE DEPARTMENT OF OCCUPATIONAL MEDICINE, AVIATION, SPACE AND DIVING MEDICINE." In The 16th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2021). FSBSI “IRIOH”, 2021. http://dx.doi.org/10.31089/978-5-6042929-2-1-2021-1-355-358.

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Abstract: The main promising directions of research activities of the department and pedagogical work with the use of new forms of professional training of specialists in the field of occupational medicine based on the concept of lifelong education and a competence-based approach are presented. The department develops "biomedicine of the future" with the involvement of the latest achievements in the field of medical biochemistry, molecular biology, bioengineering, biotechnology, medical radiobiology. The department carries out the development and implementation of programs of higher professional education for students and residents of Sechenov University and students of the DPO system, taking into account the approaches of personalized and evidence-based medicine. The department has introduced new educational technologies (blended learning), is developing modern on-line services and modular programs.

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3

Freyer, James, Mario Schillaci, Susan Carpenter, Michael Cornforth, Robert Sebring, Patricia Schor, Mark Wilder, Kathryn Thompson, and Mudundi Raju. "The Radiobiology of Ultrasoft X-rays." In Free-Electron Laser Applications in the Ultraviolet. Washington, D.C.: Optica Publishing Group, 1988. http://dx.doi.org/10.1364/fel.1988.fc3.

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We have an ongoing project using ultrasoft x-rays as a tool to investigate the mechanisms of radiation-induced damage in biological systems. The data which are derived from these studies are used to test the assumptions of current models of the biological and chemical mechanisms of radiation damage. In principle, refinement of these models should aid in the extrapolation of biological data obtained at high radiation doses to the low-dose region. Basic mechanistic data may also improve our understanding of the therapeutic application of radiation in the treatment of cancer. Soft x-rays are particularly attractive for these studies because they deposit their energy over nanometer-scale dimensions, comparable to the size of critical target structures within mammalian cells. For example, 0.28 keV characteristic x-rays from carbon generate photoelectrons which deposit all of their energy over a range of 7 nm, comparable to the dimensions of DNA strands (2-3 nm) and DNA-histone complexes (10 nm). Thus, these radiations serve as very precise probes of the energy deposition and lesion interaction requirements for biological damage.

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Звіти організацій з теми "System radiobiology"

1

Davern, Sandra, and Saed Mirzadeh. Radiobiology, Omics and Microdosimetry of Systemic and Targeted Radiotherapeutics Workshop. Office of Scientific and Technical Information (OSTI), September 2020. http://dx.doi.org/10.2172/1820871.

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