Готові списки джерел за темами / Synthesis design

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  1. Статті в журналах
  2. Дисертації
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  5. Тези доповідей конференцій
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Добірка наукової літератури з теми "Synthesis design"

Автор: Grafiati
Опубліковано: 11 березня 2023

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Статті в журналах з теми "Synthesis design"

1

Marshall, William J. "Transducer design synthesis." Journal of the Acoustical Society of America 129, no. 4 (April 2011): 2578. http://dx.doi.org/10.1121/1.3588513.

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2

Campbell, Matthew I., and Kristina Shea. "Computational design synthesis." Artificial Intelligence for Engineering Design, Analysis and Manufacturing 28, no. 3 (July 22, 2014): 207–8. http://dx.doi.org/10.1017/s0890060414000171.

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3

Chelimsky, Eleanor, George Silberman, and Judith Droitcour. "Cross design synthesis." Lancet 341, no. 8843 (February 1993): 498. http://dx.doi.org/10.1016/0140-6736(93)90253-d.

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4

Cen Xiang, Cen Xiang, Xiangshun Kong Xiangshun Kong, Feng Gao Feng Gao, Yufan Zhao Yufan Zhao, Jiang Liu Jiang Liu, and Yuan Yuan and Yuou Teng Yuan Yuan and Yuou Teng. "Design, Synthesis and Antioxidant Activity of Chalcone Derivative CMZ-3-5." Journal of the chemical society of pakistan 43, no. 5 (2021): 598. http://dx.doi.org/10.52568/000600/jcsp/43.05.2021.

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Excessive accumulation of free radicals can cause a variety of diseases. According to reports, chalcone has the activity of scavenging free radicals. In this study, we synthesized a chalcone derivative CZM-3-5 and evaluated its antioxidant activity using a chemical assessment method (2,2and#39;-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS•+) assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH•) assay and total reducing antioxidant power (FRAP) assay) and a cell model of oxidative damage induced by hydrogen peroxide (H2O2). The chemical evaluation results show that the compound CZM-3-5 has good antioxidant capacity and free radical scavenging ability. MTT analysis showed that the compound has cytoprotective activity in H2O2-induced PC12 cells, and the mechanism may be related to the cytoprotective substance superoxide dismutase (SOD) is related to the level of glutathione (GSH). Overall, our findings indicate that compound CZM-3-5 has potential antioxidant activity in vitro.
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5

Cen Xiang, Cen Xiang, Xiangshun Kong Xiangshun Kong, Feng Gao Feng Gao, Yufan Zhao Yufan Zhao, Jiang Liu Jiang Liu, and Yuan Yuan and Yuou Teng Yuan Yuan and Yuou Teng. "Design, Synthesis and Antioxidant Activity of Chalcone Derivative CMZ-3-5." Journal of the chemical society of pakistan 43, no. 5 (2021): 598. http://dx.doi.org/10.52568/000600.

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Анотація:
Excessive accumulation of free radicals can cause a variety of diseases. According to reports, chalcone has the activity of scavenging free radicals. In this study, we synthesized a chalcone derivative CZM-3-5 and evaluated its antioxidant activity using a chemical assessment method (2,2and#39;-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS•+) assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH•) assay and total reducing antioxidant power (FRAP) assay) and a cell model of oxidative damage induced by hydrogen peroxide (H2O2). The chemical evaluation results show that the compound CZM-3-5 has good antioxidant capacity and free radical scavenging ability. MTT analysis showed that the compound has cytoprotective activity in H2O2-induced PC12 cells, and the mechanism may be related to the cytoprotective substance superoxide dismutase (SOD) is related to the level of glutathione (GSH). Overall, our findings indicate that compound CZM-3-5 has potential antioxidant activity in vitro.
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6

Westerberg, Arthur W. "Synthesis in engineering design." Computers & Chemical Engineering 13, no. 4-5 (April 1989): 365–76. http://dx.doi.org/10.1016/0098-1354(89)85016-1.

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7

Juneja, Chetan, and Hemant Kothari. "Business Agility: A Systematic Review of Literature and Design Oriented Research Synthesis." Journal of Advances and Scholarly Researches in Allied Education 15, no. 6 (July 5, 2018): 198–218. http://dx.doi.org/10.29070/15/57760.

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8

Xuesong Wang and Xiaorong Tang, Xuesong Wang and Xiaorong Tang. "Design, Synthesis and Evaluate In Vitro Antifungal Activity of Novel Benzamide Derivatives." Journal of the chemical society of pakistan 41, no. 3 (2019): 549. http://dx.doi.org/10.52568/000763/jcsp/41.03.2019.

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A series of novel benzamide derivatives according to fluopicolide were designed and synthesized following the rule of combination carboxylic acid amides and amines derivatives together. The antifungal activity of the 15 new compounds were evaluated in vitro against five pathogenic fungi, including Sclerotinia sclerotiorum, Gibberella zeae, Rhizoctonia solani, Helminthosporium maydis and Botrytis cinerea. Almost all the structure have not been reported, except compounds 3, 5 and 6. A surprising finding is that all the five tested fungi breed faster than negative controls when supplementary with compound 715 , respectively.
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9

Nascimento, A. R. do, R. L. B. de A. Medeiros, M. A. de F. Melo, D. M. de A. Melo, and M. J. B. de Souza. "Optimization of MCM-48 synthesis using factorial design." Cerâmica 62, no. 364 (December 2016): 413–17. http://dx.doi.org/10.1590/0366-69132016623642028.

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Abstract MCM-48 mesoporous materials were hydrothermally synthesized according to the 22 factorial design by varying the crystallization time and temperature of the synthesis gel, and characterized by means of X-ray diffraction analysis and adsorption of N2. In the crystallization temperature and time conditions used, specific areas between 924 to 1102 m2.g-1, pore volumes between 0.015 to 0.087 cm3.g-1 and pore diameters between 3.2 to 4.0 nm were obtained. It was observed that for the syntheses performed at high temperature, the crystallization time should be reduced so that the material structure is formed.
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10

KARAKULOV, Maksim. "GDS-19 GEOMETRICAL SYNTHESIS OF A PLUNGERS ENGAGEMENT(DESIGN AND SYNTHESIS OF A PAIR OF GEARS OR OF GEAR TRAINS)." Proceedings of the JSME international conference on motion and power transmissions 2009 (2009): 98–101. http://dx.doi.org/10.1299/jsmeimpt.2009.98.

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Дисертації з теми "Synthesis design"

1

Stewart, Mark Richard. "The design and synthesis of synthetic receptors." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400852.

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2

Zha, Huiyan, and 查慧艳. "Design, synthesis and characterization of synthetic ion transporters." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/206532.

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Анотація:
In recent decades, small molecules have been widely applied to the generation of functional ion transporters. Major discoveries disclosed in this thesis include a self-assembled chloride-dependent potassium channel candidate, a physiological chloride and bicarbonate dual-transporter, and a series of efficient synthetic ion transporters. In nature, K+ channels play an important role in Ca2+ signaling, volume regulation, secretion, proliferation, and migration. The extracellular K+ concentration (4 mM) is about 40 times lower than the intracellular K+ concentration (160 mM). The opening of K+ channels consequently generates an efflux of positive charge, which hyperpolarizes or repolarizes the cellular membrane. In this research, by using fluorescence assays, NMR and patch clamp experiments, compound ZHY-CM23 was found to self-assemble into a chloride-dependent K+ selective channel mediating K+ transport across lipid bilayers and cell membranes. In addition, the synthetic K+ channel formed by ZHY-CM23 was found to be capable of generating and modulating the membrane potential of liposomes and to significantly hyperpolarize the resting membrane potential of HEK 293 cells. This finding provides new insight into developing drugs for the treatment of severe human diseases caused by K+ channel malfunction, such as arrhythmia, neurological disorders and autoimmune diseases. Cystic fibrosis is a chronic recessive disease resulting from the loss of function mutations in the gene encoding of the cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ABC family of membrane transporters. Recent findings reveal that restoring bicarbonate transport might be useful for the treatments of the underlying defect in cystic fibrosis. On the basis of fluorescence assays, NMR and short circuit current experiments, the small molecule ZHY-CM11 has been discovered to not only act as a bicarbonate transporter in lipid membranes, but also to induce chloride-dependent bicarbonate secretion in cultured calu-3 epithelia. It is a promising lead compound to be developed for the treatment of cystic fibrosis and other diseases related to chloride and bicarbonate transport defects. Through structural modifications on the bioactive ion channels and the transporters ZHY-CM23 and ZHY-CM11, some valuable information on the structure-activity relationship has been obtained, and a series of potentially biologically applicable synthetic ion transporters have been discovered.
published_or_final_version
Chemistry
Doctoral
Doctor of Philosophy
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3

Shen, Yue. "Design, synthesis and characterization of the synthetic yeast genome." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33182.

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Анотація:
With the rapid development of DNA synthesis technologies, synthetic biology has made tremendous progress in the past 15 years, in particular for synthetic genomics. Synthetic genomics is a nascent field of synthetic biology, which aims to design new biological systems/organisms to satisfy human needs. Conventional synthetic biology focuses on the redesign, construction and modeling of biological parts, pathways or genomes that do not exist in nature, while synthetic genomics encompasses technologies that allow the generation of chemically synthesized larger parts of genomes or whole genomes, with simultaneous redesign of an organism's genetic material. Synthetic genomics is painting a blueprint for a new era of biology and holds great potential for a multitude of applications, such as pharmaceuticals, biofuels and rapid generation of vaccines against emerging diseases. Chapter One gives an introduction of the current state of the art and challenges of synthetic genomics and the objectives of this study. Chapter Two demonstrates the design and construction strategy of two megabase-long synthetic yeast chromosomes, SynII and SynVII. Chapter Three describes the full characterization of SynII and SynVII. Chapter Four introduces the SCRaMbLE (Synthetic Chromosome Rearrangement and Modification by LoxPsym-mediated Evolution) system and its application in SynII and SynVII. Taken together, this work demonstrates the utility of synthetic yeast for understanding biological systems and its potential for industrial applications.
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4

Baas, Tracey Lynn. "The design, synthesis, and characterization of template assembled synthetic proteins /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/11561.

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5

Murphy, Richard. "Constraint-based design synthesis for computer aided design." Thesis, Open University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418515.

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6

Smith, Kenneth Wayne. "Fighter Aircraft Synthesis/Design Optimization." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/32821.

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Анотація:
This thesis presents results of the application of energy-based large-scale optimization of a two-subsystem (propulsion subsystem (PS) and airframe subsystem-aerodynamics (AFS-A)) air-to-air fighter (AAF) with two types of AFS-A models: a fixed-wing AFS-A and a morphing-wing AFS-A. The AAF flies 19 mission segments of a supersonic fighter aircraft mission and the results of the study show that for very large structural weight penalties and fuel penalties applied to account for the morphing technology, the morphing-wing aircraft can significantly outperform a fixed-wing AAF counterpart in terms of fuel burned over the mission. The optimization drives the fixed-wing AAF wing-geometry design to be at its best flying the supersonic mission segment, while the morphing-wing AFS-A wing design is able to effectively adapt to different flight conditions, cruising at subsonic speeds much more efficiently than the fixed-wing AAF and, thus yielding significant fuel savings. Also presented in this thesis are partially optimized results of the application of a decomposition strategy for large-scale optimization applied to a nine-subsystem AAF consisting of a morphing-wing AFS-A, turbofan propulsion subsystem (PS), environmental controls subsystem (ECS), fuel loop subsystem (FLS), vapor compression/polyalphaolefin loop subsystem (VC/PAOS), electrical subsystem (ES), central hydraulics subsystem (CHS), oil loop subsystem (OLS), and flight controls subsystem (FCS). The decomposition strategy called Iterative Local-Global Optimization (ILGO) is incorporated into a new engineering aircraft simulation and optimization software called iSCRIPTâ ¢ which also incorporates the models developed as part of this thesis work for the nine-subsystem AAF. The AAF flies 21 mission segments of a supersonic fighter aircraft mission with a payload drop simulating a combat situation. The partially optimized results are extrapolated to a synthesis/design which is believed to be close to the system-level optimum using previously published results of the application of ILGO to a five-subsystem AAF to which the partially optimized results of the nine-subsystem AAF compare relatively well. In addition to the optimization results, a parametric study of the morphing AFS-A geometry is conducted. Three mission segments are studied: subsonic climb, subsonic cruise, and supersonic cruise. Four wing geometry parameters are studied: leading-edge wing sweep angle, wing aspect ratio, wing thickness-to-chord ratio, and wing taper ratio. The partially optimized AAF is used as the baseline, and the values for these geometric parameters are increased or decreased up to 20% relative to an established baseline to see the effect, if any, on AAF fuel consumption for these mission segments. The only significant effects seen in any of the mission segments arise from changes in the leading-edge sweep angle and wing aspect ratio. The wing thickness-to-chord ratio shows some effect during the subsonic climb segment, but otherwise shows no effect along with the taper ratio in any of the three mission segments studied. It should be emphasized, however, that these changes are made about a point (i.e. synthesis/design), which is already optimal or nearly so. Thus, the conclusions drawn cannot be generalized to syntheses/designs, which may be far from optimal. Also note that the results upon which these conclusions are based may very likely highlight a weakness in the conceptual-level drag-buildup method used in this thesis work. Further optimization studies using this drag-buildup method may warrant setting the thickness-to-chord ratios and taper ratios rather than having them participate in the optimization as degrees of freedom (DOF). The final set of results is a parametric study conducted to highlight the correlation between the fuel consumption and the total exergy destruction in the AFS-A. The results for the subsonic cruise and supersonic cruise mission segments show that at least for the case when the AFS-A is optimized by itself for a fixed specific fuel consumption that there is a direct correlation between the fuel burned and total exergy destruction. However, as shown in earlier work where a three-subsystem AAF with AFS-A, PS, and ECS is optimized, this may not always be the case. Furthermore, based on the results presented in this thesis, there is a smoothing effect observed in the exergy response curves compared to the fuel-burned response curves to changes in AFS-A geometry. This indicates that the exergy destruction is slightly less sensitive to such changes.
Master of Science
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7

Ye, Yulin. "Design and synthesis of myo-inositol (1,4,5)-trisphosphate receptor antagonists : design and synthesis of IP3 receptor antagonists." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:5e75b5e0-d42a-4b58-9c46-7fabff99e10e.

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Well-regulated Ca2+ signalling is essential for every living organism, and disruption of this signalling can lead to diseases including heart failure, neurological disorders and diabetes. Intracellular Ca2+ levels are regulated by influx of extracellular Ca2+ through channels located in the cell membrane. In addition, release of Ca2+ from intracellular stores also plays an important role in controlling intracellular Ca2+ concentration. Of the three types of intracellular Ca2+ stores that have been characterised those with D-myo-Inositol 1,4,5 trisphosphate receptors (InsP3Rs) showed a close relationship with cell proliferation. Hence, selective blockage of InsP3Rs will allow better understanding of Ca2+ signalling and might also unveil novel treatment for cancers, in the long term. There were no selective InsP3Rs antagonists known at the start of these studies. Based on the crystal structure of InsP3Rs bound to InsP3 and SAR studies of InsP3, we designed and tested several InsP3 analogues.1 Compound 15, 16 and 23 acted as InsP3R antagonists, though their selectivity for InsP3Rs was not completely determined. Furthermore, we also attempted to improve the potency of 16 via substitution at the 1-postion phosphate. By considering the interaction formed between adenophosphostins and InsP3Rs compounds (53-55) were designed and synthesised. In addition, analogues of compound 92, selected from an in silico screen, have led to the discovery of another novel scaffold that acts as an InsP3R antagonist.
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8

Lange, Mark W. "Design semiosis : synthesis of products in the design activity /." Stockholm, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3243.

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9

Engelsen, Frode. "Design-oriented gust stress contraints for aeroservoelastic design synthesis /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/9965.

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10

Sun, Xiaojiao. "High Affinity Synthetic Molecular Binders for Proteins : Design, Synthesis and Evaluation." Doctoral thesis, Uppsala universitet, Fysikalisk-organisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183203.

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Анотація:
This thesis describes the design and synthesis of small molecule derivatives and their polypeptide conjugates as high affinity binders for proteins: the D-dimer protein (D-dimer), a biomarker for diagnosis of thromboembolic diseases; human myeloperoxidase (MPO), a biomarker for cardiovascular diseases; and chitinases, potential targets for asthma therapy. The interactions between the synthetic binder molecules and those proteins were evaluated by surface plasmon resonance (SPR) biosensor analysis and fluorescence spectroscopy. Competition SPR experiments or other methods proved that the small molecule components of the binder molecules were critical for binding and specifically bound to the original binding site of small molecules. The binder molecules consisted of a 42-residue helix-loop-helix polypeptide conjugated to a small molecule via aliphatic spacers of suitable length. The small molecules could be any type of moderately binding structure. In the binder development for the D-dimer, the tetrapeptide GPRP with a dissociation constant Kd of 25 μM was used and the affinity of 4C15L8GPRP obtained was estimated to be approximately 3 nM. In the binder development for MPO, salicylhydroxamic acid (SHA) with Kd of 2 μM was used and the affinity of 4C37L34C11SHA obtained was estimated to be approximately 0.4 nM. In the binder development for chitinases, a theobromine derivative (pentoxifylline) with a Kd of 43±10 μM was used and the affinity of 4C37L34-P obtained was estimated to be considerably higher than that of pentoxifylline. The binder molecules were identified from a 16-membered pool of candidates obtained by conjugating the small molecules to each member of a set of 16 designed polypeptides. The affinities were greatly enhanced by 2-3 orders of magnitude, compared to the small molecule. The polypeptides did not bind to the proteins with measurable affinities. The discovery of these new synthetic binders for protein targets can pave the way to diagnostic tests in vivo or in vitro, independent of antibodies.
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Книги з теми "Synthesis design"

1

Chakrabarti, Amaresh, ed. Engineering Design Synthesis. London: Springer London, 2002. http://dx.doi.org/10.1007/978-1-4471-3717-7.

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2

Howe, Denis. Aircraft Conceptual Design Synthesis. Chichester, UK: John Wiley & Sons, Ltd, 2000. http://dx.doi.org/10.1002/9781118903094.

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3

Taraate, Vaibbhav. ASIC Design and Synthesis. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-4642-0.

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4

K, Antonsson Erik, and Cagan Jonathan 1961-, eds. Formal engineering design synthesis. Cambridge, UK: Cambridge University Press, 2001.

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5

Aircraft conceptual design synthesis. London: Professional Engineering Pub., 2000.

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6

Jack, Li Jie, and Johnson Douglas S. 1968-, eds. Modern drug synthesis. Hoboken, N.J: Wiley, 2010.

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7

Li, Jie Jack, and Douglas S. Johnson. Innovative drug synthesis. Hoboken, New Jersey: John Wiley & Sons, 2015.

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8

1964-, Ghosh Abhijit, and Keutzer Kurt William 1955-, eds. Logic synthesis. New York: McGraw-Hill, 1994.

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9

Symmetry: A basis for synthesis design. New York: Wiley, 1995.

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10

Drug synthesis. Milton Keynes: Open University, 2009.

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Частини книг з теми "Synthesis design"

1

Navinchandra, D. "Design Synthesis." In Exploration and Innovation in Design, 51–66. New York, NY: Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4612-3114-1_4.

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2

Palazzo, Danilo, and Frederick Steiner. "Synthesis." In Urban Ecological Design, 95–130. Washington, DC: Island Press/Center for Resource Economics, 2011. http://dx.doi.org/10.5822/978-1-61091-226-6_4.

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Andreasen, Mogens Myrup, Claus Thorp Hansen, and Philip Cash. "Concept Synthesis." In Conceptual Design, 141–91. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-19839-2_7.

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Andreasen, Mogens Myrup, Claus Thorp Hansen, and Philip Cash. "Product Synthesis." In Conceptual Design, 193–226. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-19839-2_8.

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5

Bhatta, Sambasiva R., and Ashok K. Goel. "Design patterns and creative design." In Engineering Design Synthesis, 271–84. London: Springer London, 2002. http://dx.doi.org/10.1007/978-1-4471-3717-7_16.

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6

Gajski, Daniel D., Samar Abdi, Andreas Gerstlauer, and Gunar Schirner. "System Synthesis." In Embedded System Design, 113–53. Boston, MA: Springer US, 2009. http://dx.doi.org/10.1007/978-1-4419-0504-8_4.

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7

Gajski, Daniel D., Samar Abdi, Andreas Gerstlauer, and Gunar Schirner. "Software Synthesis." In Embedded System Design, 155–97. Boston, MA: Springer US, 2009. http://dx.doi.org/10.1007/978-1-4419-0504-8_5.

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Gajski, Daniel D., Samar Abdi, Andreas Gerstlauer, and Gunar Schirner. "Hardware Synthesis." In Embedded System Design, 199–254. Boston, MA: Springer US, 2009. http://dx.doi.org/10.1007/978-1-4419-0504-8_6.

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Bartlett, Paul A. "Design of Enzyme Inhibitors." In Chemical Synthesis, 137–73. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-0255-8_6.

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Andreasen, Mogens Myrup, Claus Thorp Hansen, and Philip Cash. "Product Life Synthesis." In Conceptual Design, 245–63. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-19839-2_10.

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Тези доповідей конференцій з теми "Synthesis design"

1

Sweeney, D. W., G. F. Schils, and N. C. Gallagher. "Iterative Design of Holographic Elements*." In Signal Recovery and Synthesis. Washington, D.C.: Optica Publishing Group, 1989. http://dx.doi.org/10.1364/srs.1989.thc2.

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Анотація:
Iterative synthesis is a powerful technique for designing certain types of diffractive holographic elements. The designs especially amenable to iterative methods are characterized by nonlinear partial constraints in two domains that are related through a transformation. This paper reviews three iterative design projects of this type. In the first example, holographic concepts are used to design a microwave mirror that modifies the phase of a reflected wavefront.1,2 Second, holographic correlation filters are designed that recognize a three-dimensional object viewed from any direction.3,4 Third, an iterative design for computer generated holograms makes optimum use of the recording device resolution.5,6
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2

Ciblak, Namik, and Harvey Lipkin. "Application of Stiffness Decompositions to Synthesis by Springs." In ASME 1998 Design Engineering Technical Conferences. American Society of Mechanical Engineers, 1998. http://dx.doi.org/10.1115/detc98/mech-5880.

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Abstract Stiffness decompositions originating from two distinct eigenvalue problems are applied to stiffness synthesis by springs. The resulting free-vector and line-vector syntheses provide a clear geometric explanation of the methods. Numerical examples and algorithms are also provided to verify the results.
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3

Chuenchom, Tushchai, and Sridhar Kota. "Generalized Synthesis of Adjustable Mechanisms." In ASME 1992 Design Technical Conferences. American Society of Mechanical Engineers, 1992. http://dx.doi.org/10.1115/detc1992-0304.

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Анотація:
Abstract Conventional mechanisms (cams, gears, and linkage-based that are typically single degree of freedom) are being increasingly replaced by multi-degree of freedom multi-actuators integrated with logic controllers. This new trend in sophistication although provides greatly enhanced flexibility, there are many instances where the flexibility needs are exaggerated and the associated complexity is unnecessary. On the other hand, the conventional mechanisms cannot fulfill multi-task requirements due to lack methods to design-in flexibility. Adjustable mechanisms or “programmable” mechanisms provide a cost-effective middle ground between hard automation and overly flexible expensive robots; especially for tasks that demand only limited flexibility. This paper presents a generalized synthesis procedure for designing adjustable robotic mechanisms for path generation. The goal is to develop a methodology to synthesize a single mechanism that can trace a given set of three-dimensional trajectories by simply adjusting one of the mechanism parameters; say the length of a particular link. The synthesis procedure presented in this paper entails coupler curve classification and pattern recognition techniques, eleven precision-point (Burmester theory) synthesis of geared five-bar mechanisms, multi-objective optimization and statistical analysis.
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4

Leger, Chris, and John Bares. "Automated Synthesis and Optimization of Robot Configurations." In ASME 1998 Design Engineering Technical Conferences. American Society of Mechanical Engineers, 1998. http://dx.doi.org/10.1115/detc98/mech-5945.

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Анотація:
Abstract We present an extensible system for synthesizing and optimizing robot configurations. The system uses a flexible representation for robot configurations based on parameterized modules; this allows us to synthesize mobile and fixed-base robots, including robots with multiple or branching manipulators and free-flying robots. Synthesis of modular robots is also possible with our representation. We use an optimization algorithm based on genetic programming. A distributed architecture is used to spread heavy computational loads across multiple workstations. We take a task-oriented approach to synthesis in which robots are evaluated on a designer-specified task in simulation; flexible planning and control algorithms are thus required so that a wide variety of robots can be evaluated. Our system’s extensibility stems from an object-oriented software architecture that allows new modules, metrics, controllers, and tasks to be easily added. We present two example synthesis tasks: synthesis of a robotic material handler, and synthesis of an antenna pointing system for a mobile robot. We analyze several key issues raised by the experiments and show several important ways in which the system can be extended and improved.
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5

Lee, Ming-Yih, Arthur G. Erdman, and Salaheddine Faik. "A Generalized Performance Sensitivity Synthesis Methodology for Four-Bar Mechanisms." In ASME 1992 Design Technical Conferences. American Society of Mechanical Engineers, 1992. http://dx.doi.org/10.1115/detc1992-0269.

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Abstract A generalized accuracy performance synthesis methodology for planar closed chain mechanisms is proposed. The relationship between the sensitivity to variations of link lengths and the location of the moving pivots of four-link mechanisms is investigated for the particular objective of three and four position synthesis. In the three design positions case, sensitivity maps with isosensitivity curves plotted in the design solution space allow the designer to synthesize a planar mechanism with desired sensitivity value or to optimize sensitivity from a set of acceptable design solutions. In the case of four design positions, segments of the Burmester design curves that exhibit specified sensitivity to link length tolerance are identified. A performance sensitivity criterion is used as a convenient and a useful way of discriminating between many possible solutions to a given synthesis problem.
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6

Spasić, Dragana, Anita Janković, and Milica Spasić-Stojković. "ESP Course Design for the 21st Century: Team Teaching and Hybrid Learning." In Synthesis 2015. Belgrade, Serbia: Singidunum University, 2015. http://dx.doi.org/10.15308/synthesis-2015-763-767.

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7

Hodges, P. H., and P. Pisano. "On Optimal Mechanism Synthesis via Synthesis and Analysis Operators." In ASME 1988 Design Technology Conferences. American Society of Mechanical Engineers, 1988. http://dx.doi.org/10.1115/detc1988-0052.

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Анотація:
Abstract This paper presents a general framework for mechanism synthesis based on analysis and synthesis operators. Examples of both exact synthesis and approximate synthesis arc given and the synthesis of mechanisms via optimization techniques is explained using synthesis and analysis operators. Synthesis is addressed as a mapping from the space M of rigid body motions to the space (T,D) of mechanism types and dimensions. Among the results of this formulation are an identification of cognates as mechanisms with the value t of type held constant but with a different vector of dimensions d such that the same motion m is generated. A discussion of this formulation is given, optimal mechanism synthesis is re-interpreted within this framework and some avenues for further work which are indicated by this framework are identified.
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8

Byron Krauter. "Transmission Line Synthesis." In 32nd Design Automation Conference. ACM, 1995. http://dx.doi.org/10.1109/dac.1995.249973.

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9

Yablonovich, Eli. "Design of Photonic Bandgap Structures." In Signal Recovery and Synthesis. Washington, D.C.: Optica Publishing Group, 1998. http://dx.doi.org/10.1364/srs.1998.swb.2.

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Анотація:
We will pursue the rather appealing analogy1-4 between the behavior of electromagnetic waves in artificial, 3-dimensionally periodic, dielectric structures, and the rather more familiar behavior of electron waves in natural crystals.
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10

Chiang, Chien H., Wei Hua Chieng, and David A. Hoeltzel. "Four-Position Synthesis for Spatial Mechanisms With Two Independent Loops." In ASME 1992 Design Technical Conferences. American Society of Mechanical Engineers, 1992. http://dx.doi.org/10.1115/detc1992-0334.

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Анотація:
Abstract Mathematical models that have been employed to synthesize spatial mechanisms for rigid body guidance have been found to be too complicated to implement in practical applications, especially for four-position guidance synthesis. This paper describes simple analytical methods for synthesizing single degree-of-freedom spatial mechanisms having two independent loops for four precision positions. In addition, prescribed timing has been simultaneously considered for several spatial mechanisms.
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Звіти організацій з теми "Synthesis design"

1

Doherty, M. F. Design and synthesis of reactive separation systems. Office of Scientific and Technical Information (OSTI), January 1992. http://dx.doi.org/10.2172/6759429.

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2

Petrovic, J. J., R. G. Castro, and D. P. Butt. Synthesis and design of silicide intermetallic materials. Office of Scientific and Technical Information (OSTI), April 1997. http://dx.doi.org/10.2172/494111.

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3

Reif, John. Programme DNA Lattices: Design, Synthesis and Applications. Fort Belvoir, VA: Defense Technical Information Center, February 2006. http://dx.doi.org/10.21236/ada447708.

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4

Yoon, Wonki, and Waltraud M. Kriven. Synthesis and Mirostructural Design of Oxide Fibers. Fort Belvoir, VA: Defense Technical Information Center, December 2005. http://dx.doi.org/10.21236/ada450946.

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5

Hoffman, Marshall M. Design, Synthesis and Testing of Novel Antimalarial. Fort Belvoir, VA: Defense Technical Information Center, May 2006. http://dx.doi.org/10.21236/ada452979.

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6

Palyulin, Vladimir A. Computer-Aided Synthesis Design of Energetic Compounds. Fort Belvoir, VA: Defense Technical Information Center, November 2008. http://dx.doi.org/10.21236/ada525358.

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7

Petrovic, J. J., R. G. Castro, R. U. Vaidya, and Y. Park. Synthesis and Design of Silicide Intermetallic Materials. Office of Scientific and Technical Information (OSTI), May 1999. http://dx.doi.org/10.2172/759127.

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8

Bernstein, J., J. Y. Becker, S. Bittner, and S. S. Shaik. Electrically Conducting Organic Materials: Design, Synthesis and Characterization. Fort Belvoir, VA: Defense Technical Information Center, February 1988. http://dx.doi.org/10.21236/ada195095.

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9

Petrovic, J. J., R. G. Castro, and D. P. Butt. Synthesis and design of intermetallic materials - molybdenum disilicide. Office of Scientific and Technical Information (OSTI), May 1995. http://dx.doi.org/10.2172/105116.

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10

Murphy, Kevin. Design and Synthesis of Novel Chloroquine-based Antimalarials. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.2619.

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