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Статті в журналах з теми "Sulfa drugs"
Jones, Susan. "How sulfa drugs work." Nature Biotechnology 30, no. 4 (April 2012): 333. http://dx.doi.org/10.1038/nbt.2188.
Повний текст джерелаal-Rashida, Mariya, Sajad Hussain, Mehwish Hamayoun, Aisha Altaf, and Jamshed Iqbal. "Sulfa Drugs as Inhibitors of Carbonic Anhydrase: New Targets for the Old Drugs." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/162928.
Повний текст джерелаJayachandran, Seema, Adriana Lleras-Muney, and Kimberly V. Smith. "Modern Medicine and the Twentieth Century Decline in Mortality: Evidence on the Impact of Sulfa Drugs." American Economic Journal: Applied Economics 2, no. 2 (April 1, 2010): 118–46. http://dx.doi.org/10.1257/app.2.2.118.
Повний текст джерелаLaub, George R. "Discovery of the Sulfa Drugs." Southern Medical Journal 79, no. 6 (June 1986): 782. http://dx.doi.org/10.1097/00007611-198606000-00040.
Повний текст джерелаPatel, Onisha G., Eddy K. Mberu, Alexis M. Nzila, and Ian G. Macreadie. "Sulfa drugs strike more than once." Trends in Parasitology 20, no. 1 (January 2004): 1–3. http://dx.doi.org/10.1016/j.pt.2003.10.009.
Повний текст джерелаEllaithy, M. M., S. Z. El-Khateeb, and M. F. El-Tarras. "Colorimetric microdetermination of some sulfa drugs." Microchemical Journal 33, no. 2 (April 1986): 168–71. http://dx.doi.org/10.1016/0026-265x(86)90050-0.
Повний текст джерелаCaira, Mino R. "Sulfa Drugs as Model Cocrystal Formers." Molecular Pharmaceutics 4, no. 3 (May 4, 2007): 310–16. http://dx.doi.org/10.1021/mp070003j.
Повний текст джерелаBoreen, Anne L., William A. Arnold, and Kristopher McNeill. "Photochemical Fate of Sulfa Drugs in the Aquatic Environment: Sulfa Drugs Containing Five-Membered Heterocyclic Groups." Environmental Science & Technology 38, no. 14 (July 2004): 3933–40. http://dx.doi.org/10.1021/es0353053.
Повний текст джерелаIliades, Peter, Steven R. Meshnick, and Ian G. Macreadie. "Mutations in the Pneumocystis jirovecii DHPS Gene Confer Cross-Resistance to Sulfa Drugs." Antimicrobial Agents and Chemotherapy 49, no. 2 (February 2005): 741–48. http://dx.doi.org/10.1128/aac.49.2.741-748.2005.
Повний текст джерелаHaller, J. S. "The First Miracle Drugs: How the Sulfa Drugs Transformed Medicine." Journal of the History of Medicine and Allied Sciences 63, no. 1 (August 5, 2007): 119–21. http://dx.doi.org/10.1093/jhmas/jrm035.
Повний текст джерелаДисертації з теми "Sulfa drugs"
Portieri, Alessia. "Solid state NMR of sulfa-drugs." Thesis, Durham University, 2001. http://etheses.dur.ac.uk/3781/.
Повний текст джерелаHossain, G. M. Golzar. "Syntheses and structural studies of metal complexes of sulfa drugs." Thesis, Cardiff University, 2005. http://orca.cf.ac.uk/56117/.
Повний текст джерелаElbakush, Rasha Elmheidi. "A crystal engineering study of selected sulfa drugs and trimethoprim." Thesis, University of the Western Cape, 2014. http://hdl.handle.net/11394/4651.
Повний текст джерелаThe objective was to prepare new solid phases, i.e. co-crystal forms, of two sulfa antibiotic drugs (sulfamethoxazole and sulfasalazine) with trimethoprim and fourteen potential co-formers with GRAS status. Trimethoprim was chosen for its synergistic effects with both sulfa drugs and the other co-formers were selected in an attempt to improve the physicochemical properties of the antibiotics. A variety of co-crystallization techniques, including solvent assisted grinding, slow evaporation, slurry method and solidification of the melt were used to obtain these results. From these methods, three new solid phases were successfully isolated for the sulfamethoxazole antibiotic, viz. sulfamethoxazole-benzoic anhydride (SMZ-BAN) co-crystal by the slurry method, amorphous sulfamethoxazole-trimethoprim (SMZ-TMP) form by solidification of the melt and amorphous sulfamethoxazole-oxalic acid (SMZ-OA) by slow evaporation. For the sulfasalazine antibiotic, co-crystallization experimentation produced, sulfasalazine-trimethoprim salt (SSZ-TMPs) by slow evaporation, sulfasalazine-trimethoprim co-crystal (SSZ-TMP) by solvent assisted grinding and sulfasalazine-nicotinamide co-crystal (SSZ-NC) by solidification of the melt. Of these six compounds subjected to single crystal X-ray analysis, only one of their structures was elucidated i.e. the salt, SSZ-TMPs. Different techniques that were used to assess the thermal behaviour of the products included hot stage microscopy, differential scanning calorimetry and thermogravimetric analysis. FTIR provided information on the purity of the compounds and the suggested host-guest interaction sites. X-ray powder diffraction supported the determination of the new phase comparative to the parent compounds. Finally dissolution testing was carried out for successful candidates with encouraging recommendations for future work.
Hayton, Karen. "The genetics of resistance to antifolate and sulfa drugs in malaria parasites." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/14032.
Повний текст джерелаChen, Yun-Chun, and 陳筠鈞. "HLA association in sulfa drugs-, cephalosporin-related hypersensitivity reactions." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/3r4bw8.
Повний текст джерела國立陽明大學
藥理學研究所
102
Adverse drug reaction is an important issue in the hospital. Some adverse drug reaction, including angioedema, lead patients to feel uncomfortable, and some even cause patients to die. The life-threatening adverse drug reaction includes toxic epidermal necrolysis and Stevens-Johnson syndrome. The mortality rate is about 10-15%. Recent report suggests that HLA alleles are associated with severe cutaneous adverse drug reaction. However, it’s unclear that whether antibiotics, including sulfa drug, cephalosporin, and vancomycin, are related to HLA. We enrolled patients with sulfa drugs-, cephalosporin-, or vancomycin-induced type I /IV hypersensitivity to analyze the association with HLA alleles. The results indicated that HLA-DRB1*gene 3 is associated with sulfa drug-induced type I hypersensitivity (Pc=0.016). HLA-B*genewas related to sulfa drug-induced type IV hypersensitivity (Pc=0.001) and HLA-B*gene 2 was associated with Baktar-induced MPE/DRESS (Pc=0.006). On the other hand, cephalosporin-induced type I hypersensitivity showed no association with HLA, but there was significant different between cephalosporin-induced type IV hypersensitivity and HLA-B*gene(Pc=0.002). We further examined the metabolic gene polymorphism, but did not found significant difference between sulfa drugs-induced type IV hypersensitivity and NAT2-rs1799931 (P=0.432), CYP2C9*3 (P=0.406), and CYP2C19-rs3758581 (P=0.282). We also found that 37.5%(6/16) of sulfamethoxazole-induced type IV hypersensitivity patients showed higher plasma concentration of sulfamethoxazole than healthy controls. The results indicated that sulfa drug-, or cephalosporin-induced type IV hypersensitivity is associated with specific HLA alleles.
Yao, Yu Chun, and 姚幼莙. "Analysis of sulfa drugs residues in Taipei processed eggs by UPLC-MS/MS." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/13278648550270787035.
Повний текст джерела國立臺灣海洋大學
食品科學系
97
By feeding animals with antibiotics, the poultries can be raised with good health. However, if the industry used high-dose of antibiotics for the treatment of disease and did not comply with any governmental regulations of meat and egg, drug residues would be occurred in food. In this study, five different kinds of processed eggs obtained in the markets were used to analyze the sulfa drugs residues. After the processed egg homogenizing, different organic solvents were used to study the extraction efficiency. The extracts were partially purified by solid-phase extraction. The ultra performance liquid chromatography tandem mass spectrometry UPLC/MS/MS was used to study five different sulfa drugs in this studies, and the fragments SDZ 251.04>156.0, 251.04>92.1;SMT 279.16>124.0, 279.16>92.0;SMM 281.10>156.0, 281.10>92.0;SQX 301.10>155.9, 301.10>92.0及SDM 311.11>156.0, 311.11>92.0 were used to mass analysis.The results shown the linear range of 1 ppb ~ 100 ppb could be achieved, correlation coefficient of SDZ, R2 = 0.9985; SMT, R2 = 0.9993;SMM, R2 = 0.9999; SQX, R2 = 0.9983; SDM, R2 = 0.9998. Method detection limit (MDL) SDZ: 1.95 ppb; SMT: 1.34 ppb; SMM: 1.83 ppb; SQX: 2.04 ppb; SDM: 1.85 ppb.
Zhuang, Yu-De, and 莊鈺德. "Environment-sensitive Fluorescent Probes for The Selective Detection of Proteins and Sulfa Drugs." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/17997464546993851799.
Повний текст джерела國立清華大學
化學系
101
Protein, metabolite and drug molecule detection is important in medical diagnosis as well as in biology to investigate cellular processes. Fluorescent probes which can detect specific proteins and small molecules are particularly valuable as they allow for sensitive, simple and specific detection with high signal-to-background ratios. In this thesis, we introduce two new general approaches to generate fluorescent sensor for the selective detection of proteins and small molecules, respectively. Currently most of the small molecule fluorescent turn-on probes are designed for monitoring enzyme activities, e.g., glycosidases, proteases, lactamases and kinases. Typically, their fluorescence turn-on mechanism is based on the enzymatic reaction with the chemical probes to convert the non-fluorescence substrate into the fluorescence product. On the other hand, the design of fluorescence probes for non-enzymatic proteins remains a challenging task. In the first part of the thesis, we introduce a new type of fluorescent turn-on probes, where a small molecule ligand is conjugated to an environment-sensitive SBD fluorophore, for the selective detection of both enzymes and non-enzymatic proteins. The fluorescent turn-on mechanism is based on the binding of the ligand to a hydrophobic ligand binding domain of the target protein whereby the close proximity to the hydrophobic environment can influence the environment-sensitive fluorophore to exhibit stronger fluorescence. Our new fluorescent probe design is modular and versatile as illustrated by the three fluorescent probes synthesized based on this design for the specific detection of hCAII, trypsin and avidin with fluorescent turn-on ratios of up to 17-fold. In the second part of the thesis, we describe a novel semisynthetic fluorescent sensor for the selective detection of sulfa drugs. The semisynthetic sensor is to mimic open and closed conformation of the periplasmic binding protein upon substrate binding. Covalent labeling of the synthetic sulfonamide inhibitor and environment-sensitive SBD-dye conjugate to the HCAII enzyme was achieved by introducing a self-labeling protein SNAP-tag to HCAII to facilitate quantitative and site-specific labeling via benzylguanine (BG) moiety. We have successfully demonstrated that addition of synthetic molecule to the sensor protein SNAP_HCAII can achieve a fluorescence intensity increase of more than 10-fold. Subsequent addition of sulfonamide drugs to the semisynthetic fluorescent sensor reverses the SBD-dye to its initial non-fluorescent state. This semisynthetic fluorescent sensor has been applied in the detection of several sulfonamide drugs, such as ethoxzolamide and acetazolamide. The two fluorescent sensors described in this thesis provide a general approach for the selective detection of proteins, metabolites and drug molecules. We believe that these novel fluorescent probe designs will be a very useful approach for a wide range of applications, such as diagnosis and molecular imaging where high fluorescent signal change and simple detection methods are required.
TSAI, HUAI-KANG, and 蔡懷慷. "Electrochemical Reaction and Analytical Application of Sulfa Drugs in the Presence of Catechol." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/bte55a.
Повний текст джерела國立暨南國際大學
應用化學系
106
The sulfonamide detection method mainly includes mass spectrometry and chromatography. In electrochemical detection, molecular imprinting technology and activated carbon materials are also used. However, mass spectrometry and chromatography are expensive, and the previous electrochemical methods also have a drawback that the current signal is not obvious and the electrode modification is complicated. In this study, carboxylic acid-functionalized multi-walled carbon nanotubes were first modified on a screen-printed carbon electrode, followed by electrochemical treatment, and then an activated carbon nanotubes modified electrode (SPCE/MWCNTRD) was successfully prepared. When using cyclic voltammetry to examine sulfanilamide in the presences of the potential range of -0.2V to +0.8V in an acidic environment, catechol will be oxidized on the surface of the electrode to promote the formation of quinone-amine polymers, and a new redox pair can be observed at +0.13V, which can be was use for quantification of the sulfonamide by differential pulse voltammetry (DPV). Two linear ranges of 0.5-10 μM and 10-50 μM were obtained. The lowest detection limit of this method was 19.2 nM. In this study, we use a simple modification method to effectively determine sulfanilamide.
kung, Te-an, and 龔得安. "Development of analytical methodologies for sulfa drugs and pharmacokinetics studies of sulfamonomethoxine in tilapia." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/gkd628.
Повний текст джерела國立中山大學
海洋生物科技暨資源學系研究所
104
A rapid and efficient multiresidue method that involves using improved QuEChERS method and LC–ESI–MS/MS was developed to measure trace levels of sulfonamides in fish tissues. This proposed method was proven to be a powerful, highly sensitive, and environmentally friendly analytical tool that requires minimal sample preparation. The typical MS/MS fragmentation patterns of the [M+H]+ were 156 m/z, 108 m/z, and 92 m/z. Separation was performed on HC-C18 columns with a gradient elution by using methanol and 5 mM ammonium acetate aqueous solution (adjusted to pH 3.5 with formic acid). This method was validated and exhibited favorable performance as well as acceptable accuracy (80.2–93.5%), precision (3.82–8.71%), sensitivity (limits of detection (LODs) 0.43–1.22 μg kg-1 and limits of quantification (LOQs) 1.27–3.71 μg kg-1), and an acceptable matrix effect (-18.2–18.4%). This methodology has been successfully applied in analyzing various fish tissue from local markets. The pharmacokinetics of sulfamonomethoxine (SMM) were estimated after single oral administration (100 mg/kg body weight) to the tilapia at 25.0 °C and drug concentration–time profiles for blood and tissues were described by the non–compartmental model. In the pharmacokinetics studies, the results indicated high levels of SMM appeared usually in the well perfused tissues, such as liver and bile, whereas low levels of SMM were generally found in the poorly perfused tissues, such as muscle. Acetylation of SMM in tilapia following oral administration was 45% and N4-acetyl sulfamonomethoxine (AC-SMM) was the major acetylated metabolite observed. T1/2 of AC-SMM (46.2 h) was longer than of SMM (21.7 h) in blood. Redistribution occurred in blood SMM from 96 h to 120 h and in blood AC-SMM from 48 h to 72 h. With regard to the drug excretion pathway, it was concluded that SMM and AC-SMM were excreted mainly by the biliary in the tilapia. Moreover, bile excretion may result in enterohepatic cycling and to some extent retard drug elimination. In the PK–PD modeling of SMM study, the Cmax (9.6 mg kg-1) was above MIC value of Aeromonas salmonicida subsp. Salmonicida (3.12 mg kg-1), Vibrio anguillarum (3.12 mg kg -1) and Vibrio harveyi (6.25 mg kg -1). These results illustrated that SMM can inhibit the growth of certain aquatic bacterial pathogens.
CHEN, YU-MIN, and 陳玉敏. "High-performance liquid chromatographic separation of sulfa drugs and tetracycline antibiotics in feeds and animal tissues." Thesis, 1988. http://ndltd.ncl.edu.tw/handle/29339850374599485237.
Повний текст джерелаКниги з теми "Sulfa drugs"
Lesch, John E. The first miracle drugs: How the sulfa drugs transformed medicine. New York, NY: Oxford University Press, 2005.
Знайти повний текст джерелаThe first miracle drugs: How the sulfa drugs transformed medicine. New York: Oxford University Press, 2006.
Знайти повний текст джерелаPowell, Stephen E. Abstracts on sulfa drugs pertinent to livestock and poultry. Edited by Holstein-Delgass Elizabeth, Purdue University. Cooperative Extension Service., and Purdue University. Dept. of Animal Sciences. West Lafayette, Ind: Purdue University, Cooperative Extension Service [and] Animal Sciences Dept., 1985.
Знайти повний текст джерелаCorleone, Franco. Lotta alla droga: I danni collaterali : l'impatto sul carcere e sulla giustizia della legge contro gli stupefacenti in Toscana. Firenze: Polistampa, 2010.
Знайти повний текст джерелаLotta alla droga: I danni collaterali : l'impatto sul carcere e sulla giustizia della legge contro gli stupefacenti in Toscana. Firenze: Polistampa, 2010.
Знайти повний текст джерелаStudio sulla contaminazione ambientale delle acque causata dall'escrezione umana dei farmaci. Firenze: Firenze University Press, 2007.
Знайти повний текст джерелаSantambrogio, Ambrogio. I minorenni e la droga: Una ricerca sulla realtà umbra. Napoli: Edizioni scientifiche italiane, 1994.
Знайти повний текст джерелаGennaro, Giuseppe Di. La droga: Traffico, abusi, controlli : commento al Testo unico 9 ottobre 1990, n. 309, sulla disciplina degli stupefacenti e sostanze psicotrope : raccolta completa delle disposizioni emanate per l'attuazione della disciplina. 3rd ed. Milano: Giuffrè, 1992.
Знайти повний текст джерелаKerouac, Jack. Sulla strada. Oscar Mondadori: Mondadori, 1989.
Знайти повний текст джерелаFantoma, Andrea. Normalmente stupefacente: Indagine sulla percezione dell'opinione pubblica in Italia del fenomeno droga. Milano, Italy: FrancoAngeli, 2005.
Знайти повний текст джерелаЧастини книг з теми "Sulfa drugs"
"Sulfa Drugs (Sulfonamides)." In Experiments in Pharmaceutical Chemistry, 137–42. CRC Press, 2014. http://dx.doi.org/10.1201/b16563-21.
Повний текст джерела"Fluoroquinolones, Sulfa Drugs, and Antituberculosis Drugs." In Revenge of the Microbes, 83–97. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555817602.ch7.
Повний текст джерелаLesch, John E. "Chemistry and Biomedicine in an Industrial Setting: The Invention of the Sulfa Drugs." In Chemical Sciences in the Modern World, edited by Seymour H. Mauskopf. Philadelphia: University of Pennsylvania Press, 1993. http://dx.doi.org/10.9783/9781512804416-008.
Повний текст джерелаM. Patil, Sachin, and Parag Patel. "Bactericidal and Bacteriostatic Antibiotics." In Infectious Diseases and Sepsis [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.99546.
Повний текст джерела"SULFA-METHOXAZOLE." In Litt's Drug Eruption and Reaction Manual, 332–35. CRC Press, 2015. http://dx.doi.org/10.1201/b17996-122.
Повний текст джерела"SULFA-METHOXAZOLE." In Litt's Drug Eruptions and Reactions Manual, 412–15. CRC Press, 2014. http://dx.doi.org/10.1201/b15347-189.
Повний текст джерела"Dermatology: Erythema Nodosum After Taking a Sulfa Drug." In AM:STARs: Common Clinical Situations: A Resource for Practical Care and Exam Review, Vol. 28, No. 1, 35–36. American Academy of Pediatrics, 2017. http://dx.doi.org/10.1542/9781610020732-18.
Повний текст джерелаKinch, Michael. "Why Regulate Medicines?" In Prescription for Change. University of North Carolina Press, 2016. http://dx.doi.org/10.5149/northcarolina/9781469630625.003.0002.
Повний текст джерелаGilsdorf, Janet R. "Antibiotics." In Continual Raving, 169–82. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190677312.003.0009.
Повний текст джерелаТези доповідей конференцій з теми "Sulfa drugs"
Zhou, Fang, Junwei Zhang, Dafang Fu, and Hanqi Cheng. "Notice of Retraction: Degradation of Sulfa Drugs by Photolysis and Photocatalysis." In 2011 5th International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2011. http://dx.doi.org/10.1109/icbbe.2011.5780979.
Повний текст джерелаRadhi, Ahmed Wheed, Ezzat H. Zimam, and Ali Jabbar Radhi. "Synthesis and study thermal properties of some new maleimide polymers contain sulfa drugs." In 3RD INTERNATIONAL SCIENTIFIC CONFERENCE OF ALKAFEEL UNIVERSITY (ISCKU 2021). AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0067295.
Повний текст джерелаMuškinja, Jovana M., Jelena S. Katanić Stanković, and Zoran R. Ratković. "SYNTHESIS AND ANTIOXIDANT ACTIVITY OF SOME NEW SULFONAMIDE DERIVATIVES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.351m.
Повний текст джерелаFahad, Mahmood M., Ezzat Hussien Zimam, Ali Jabbar Radhi, Majid Jary Mohamud, and Nadheema Abed Abbas. "Based on sulfa drug: Synthesis and biological study of barbituric acid derivatives containing 1,2,3-Triazoline moiety." In 3RD INTERNATIONAL SCIENTIFIC CONFERENCE OF ALKAFEEL UNIVERSITY (ISCKU 2021). AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0066844.
Повний текст джерелаChang, Tsung-Yao, and Chii-Wann Lin. "Solutions of SAT Problems Solved by a SPR-Based DNA Processor." In ASME 2008 First International Conference on Micro/Nanoscale Heat Transfer. ASMEDC, 2008. http://dx.doi.org/10.1115/mnht2008-52036.
Повний текст джерелаЗвіти організацій з теми "Sulfa drugs"
Jayachandran, Seema, Adriana Lleras-Muney, and Kimberly Smith. Modern Medicine and the 20th Century Decline in Mortality: Evidence on the Impact of Sulfa Drugs. Cambridge, MA: National Bureau of Economic Research, June 2009. http://dx.doi.org/10.3386/w15089.
Повний текст джерела