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Статті в журналах з теми "Spectrométrie de masse SALDI":
Papet, Yves. "Spectrométrie de masse." EMC - Biologie Médicale 1, no. 1 (January 2006): 1–3. http://dx.doi.org/10.1016/s2211-9698(06)76428-7.
Adriaens, Annemie. "Spectrométrie de Masse." Analytica Chimica Acta 311, no. 2 (July 1995): 239. http://dx.doi.org/10.1016/0003-2670(95)90293-7.
Baudin, Bruno. "Avant-Propos – Spectrométrie de masse." Revue Francophone des Laboratoires 2011, no. 437 (December 2011): 29–30. http://dx.doi.org/10.1016/s1773-035x(11)71209-6.
Baudin, Bruno. "Protéomique et spectrométrie de masse." Revue Francophone des Laboratoires 2011, no. 437 (December 2011): 31–40. http://dx.doi.org/10.1016/s1773-035x(11)71210-2.
Gravet, A., and M. Gessier. "Spectrométrie de masse et microbiologie." Immuno-analyse & Biologie Spécialisée 28, no. 5-6 (October 2013): 297–308. http://dx.doi.org/10.1016/j.immbio.2013.09.003.
Bourlés, Didier L., Quentin Simon, and Nicolas Thouveny. "La spectrométrie de masse par accélérateur." Reflets de la physique, no. 66 (July 2020): 16–21. http://dx.doi.org/10.1051/refdp/202066016.
Beaugrand, CG. "Plasmas, ions et spectrométrie de masse." Journal de Chimie Physique 90 (1993): 1407–10. http://dx.doi.org/10.1051/jcp/1993901407.
Menet, Marie-Claude. "Principes de la spectrométrie de masse." Revue Francophone des Laboratoires 2011, no. 437 (December 2011): 41–53. http://dx.doi.org/10.1016/s1773-035x(11)71211-4.
Drowart, J. "Études Thermochimiques Par Spectrométrie de Masse." Bulletin des Sociétés Chimiques Belges 73, no. 5-6 (September 2, 2010): 451–58. http://dx.doi.org/10.1002/bscb.19640730514.
Moussa, Fathi, Jean-François Benoist, Elizabeth Thioulouse, Marie-Clotilde Berthe, and Rémy Couderc. "Spectrométrie de masse et maladies métaboliques héréditaires." Revue Francophone des Laboratoires 2011, no. 437 (December 2011): 65–72. http://dx.doi.org/10.1016/s1773-035x(11)71213-8.
Дисертації з теми "Spectrométrie de masse SALDI":
Moustiez, Paul. "Fabrication de nano-aiguilles en silicium en vue d'une détection intracellulaire de biomarqueurs de maladies neurodégénératives." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. https://pepite-depot.univ-lille.fr/ToutIDP/EDENGSYS/2023/2023ULILN054.pdf.
Neurodegenerative diseases are chronic progressive diseases affecting the central nervous system. While these diseases have multifactorial origins, their prevalence increases with age. Due to the progressive aging of the population and the absence of treatment, they are becoming a crucial public health issue. For example, Alzheimer's disease will affect 1 person out of 85 worldwide by 2050. In this context, researchers are studying various options to gain a better understanding of this disease and its pathophysiological mechanisms. They now know that hyperphosphorylation of the Tau protein and the production of toxic forms of beta-amyloid peptides that aggregate into senile plaques are the main causes. The origin of these dysfunctions is still poorly understood but could be elucidated by studying intracellular biochemical mechanisms. In this context, we have conceived an in vitro device based on the use of silicon nanoneedles with the ability to probe the cytoplasm of neuronal cells to detect Alzheimer's biomarkers and monitor their evolution. Our work was based on the development of this sensor, which was divided into 3 points. The first was the fabrication of nanoneedles through the development of cost-effective techniques such as nanosphere lithography followed by wet or dry etching methods. The second point was the optimization of these needles for the bimodal identification of molecules by mass spectrometry (SALDI-MS) and surface-enhanced Raman spectroscopy (SERS). The third point focused on the study of the interaction between our needles and neurons with the aim of capturing biomarkers and preserving cellular integrity. Nanosphere lithography was successfully developed, and the needles were manufactured using two methods: metal assisted chemical etching (MACE) and dry etching by continuous plasma etching. Rhodamine 6G, standard peptides, and beta-amyloid peptides could be detected by SALDI-MS and SERS on our needle arrays. Finally, we observed the biocompatibility of our needles with the cellular environment and characterized their interaction
Suarez, Stéphanie. "Microbiologie clinique et spectrométrie de masse." Phd thesis, Université René Descartes - Paris V, 2013. http://tel.archives-ouvertes.fr/tel-00920410.
Jankowski, Krzysztof. "Spectrométrie de masse des acides nucléiques." Paris 11, 1985. http://www.theses.fr/1985PA112257.
The nucleic acids and the oligonucleotides have been studied by using different mass spectrometric techniques. Through the revue and three chapters of particular interest (fragmentation mechanisms under normal and slowed down pyrolysis conditions, some biochemical applications and finally the oligonucleotide sequence studies using FAB ionization) we present these studies
Gilles, Isabelle. "Spectrométrie de masse et réactivité chimique." Montpellier 2, 1995. http://www.theses.fr/1995MON20080.
Jeanne, dit Fouque Kevin. "Différenciation de topoisomères peptidiques par spectrométrie de masse à mobilité ionique et spectrométrie de masse en tandem." Rouen, 2016. http://www.theses.fr/2016ROUES020.
Lasso peptides are ribosomally synthesized and post-translationnally modified peptides produced by bacteria, sharing a mechanically interlocked topology that is essential for their biological activity. This PhD work focused on the structural characterization of lasso peptides and differentiation between their branched-cyclic topoisomers using ion mobility – mass spectrometry (IM-MS) and tandem mass spectrometry (MS/MS). IM-MS studies led to the development of a method based on the use of a supercharging reagent, highlighting an additional charge state of multiply protonated species, for which the lasso and branched-cyclic topologies were clearly differentiated and separated in mixture. To assess the developed method, this strategy was also applied to other types of constrained (macrocyclic, disulfide bonds) and unconstrained (linear) structures. IRMPD spectroscopy studies allowed to characterize the changes in the hydrogen bond network, associated with the unfolding of the gas phase conformation, as a function of the charge state of multiply protonated species. The spectroscopic data could thus be correlated with the ion mobility data. IM-MS provides an overview of the conformation through a collision cross section measure (CCS), while IRMPD spectroscopy allows to probe intramolecular interactions through the hydrogen bonds. The structural characterization of lasso and branched-cyclic peptides was also carried out using MS/MS of triply protonated species. These experiments enabled us to establish general rules of fragmentation evidencing lasso topologies in collision induced dissociation (CID) and electron transfer dissociation (ETD)
Domalain, Virginie. "Différenciation de stéréoisomères par couplage, spectrométrie de masse et spectrométrie de mobilité ionique." Rouen, 2014. http://www.theses.fr/2014ROUES023.
This PhD work deals with analysis of stereoisomers, which present very close collision cross section difference (DeltaCCS ≤ Å2), by the coupling of ion mobility spectrometry and mass spectrometry (IM-MS). A study of diastereoisomers M which are functionalized entities found in a lot of natural products, rise to an efficient strategy based on cationisation (with alkali cations X and transition metals (X)II) and formation of multimers [3M+X]+ and [3M+(X)II-H]+ allowing the differentiation and the separation of stereoisomers, particularly enantiomers of amino acids and diastereomers with a major biological interest. It has been highlighted that the cationisation allows a significant increase of the stereoisomers differenciation. Then, we have shown that the nature of asymmetric center substituents plays an important role on the ion mobility separation
Tirsoaga, Alina. "Analyse structurale d'endotoxines bactériennes par spectrométrie de masse." Paris 11, 2007. http://www.theses.fr/2007PA112002.
Endotoxins are lipopolysaccharides (LPS) made up of a lipid - (called lipid A) and a sugar - chain, both characteristic of each bacterial species. We developed methods of structure analysis and a purification method representing an important improvement for studies of structure/activity relationships. The first one is a micro analytical method that can be applied to milligram quantities of bacteria. With it, one can obtain spectra of the lipid A in one day, instead of a week as for previous techniques. The second one leads to the determination of the structure and the positions of the fatty acids with a little amount of lipid A. This technology was applied to Citrobacter, an Enterobacterium causing nosocomial diseases. A LPS purification method gave highly purified samples suitable for biological tests. This method will give preparation having identical activities in different laboratories. We also have established the existence of new constituents on the lipid A of B. Bronchiseptica, from which the whooping cough originated. The presence of a glucosamine on the phosphate group(s) was demonstrated and its effect on the biological activities will be of high impact particularly on the activity of anti-bacterial peptides, as glucosamines neutralise the lipid A structure responsible for the endotoxic activities of LPS
Causse, Jean Etienne. "Spectrométrie de masse de quatre séries de phosphonates." Montpellier 2, 1991. http://www.theses.fr/1991MON20231.
Vanbellingen, Quentin. "Imagerie de substances naturelles par spectrométrie de masse." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS172/document.
This thesis was devoted to the improvement of mass spectrometry imaging methods, and to their use for in situ analysis of natural substances. The first part of this thesis has been dedicated to the development of a new acquisition mode in TOF-SIMS imaging able to acquire images with a high spatial resolution of 400 nm while keeping a good mass resolution. For that, a delayed extraction of the secondary ions has been characterized and optimized. Then, a second part has been dedicated to the study of heartwood production in a tropical species named Dicorynia guianensis. This species is one of the most exploited in French Guiana for its heartwood which exhibits a good durability. Metabolic changes are shown by sub-micrometric resolution ion images recorded in and around the transition zone, where the heartwood formation occurs. Then, TOF-SIMS and MALDI-TOF have both been used to analyse the surface of a bacterial competition. Species have been isolated from a Japanese conifer (Cephalotaxus harringtonia), from which the stains are an endophitic fungi (Paraconiothyrium variabile) and a pathogenic bacteria of the conifer (Bacillus subtilis). The results have shown that the fungus is able to hydrolyze surfactines produced by the bacteria during the competition. Furthermore, both the MALDI-TOF and the TOF-SIMS mass spectrometry imaging are methods of choice to study in vitro models of what could happen in vivo
Collard-Simard, Gabriel. "Caractérisation du récepteur de l'insuline par spectrométrie de masse." Thesis, Université Laval, 2008. http://www.theses.ulaval.ca/2008/25309/25309.pdf.
Книги з теми "Spectrométrie de masse SALDI":
Constantin, Emilia. Spectrométrie de masse: Principes et applications. Paris: Technique et documentation-Lavoisier, 1986.
Hoffmann, Edmond de. Mass spectrometry: Principles and applications. 2nd ed. Chichester: Wiley, 2001.
Hoffmann, Edmond de. Mass spectrometry: Principles and applications. 3rd ed. Chichester, England: J. Wiley, 2007.
Hoffmann, Edmond de. Mass spectrometry: Principles and applications. Chichester: Wiley, 1996.
1935-, Rosen Joseph D., ed. Applications of new mass spectrometry techniques in pesticide chemistry. New York: Wiley, 1987.
Rosenberg. Mass spectrometry and gas chromatography. New Delhi, India: Rajat Publications, 2003.
Davis, R. Mass spectrometry: Analytical chemistry by open learning. Edited by Frearson Martin, Prichard F. Elizabeth 1937-, and ACOL. Chichester: Published on behalf of ACOL by Wiley, 1987.
B, Armentrout Peter, Caprioli R. M, and Gross Michael L, eds. Encyclopedia of mass spectrometry. San Diego, CA: Elsevier, 2003.
Holmes, John L. Assigning structures to ions in mass spectrometry. Boca Raton: CRC Press, 2007.
Giorgio, Montaudo, and Lattimer Robert, eds. Mass spectrometry of polymers. Boca Raton, Fla: CRC Press, 2002.
Частини книг з теми "Spectrométrie de masse SALDI":
"5. Spectrométrie de masse." In Les fondements de la détermination des structures moléculaires, 107–36. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-2152-5-007.
"5. Spectrométrie de masse." In Les fondements de la détermination des structures moléculaires, 107–36. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-2152-5.c007.
Gratuze, Bernard. "Application de la spectrométrie de masse à plasma." In Circulation et provenance des matériaux dans les sociétés anciennes, 243–72. Editions des archives contemporaines, 2014. http://dx.doi.org/10.17184/eac.4101.
Звіти організацій з теми "Spectrométrie de masse SALDI":
Gueddari, K., M. R. LaFlèche, and J. Amossé. Extraction chimique des éléments du groupe du platine et de l'or et détermination de leurs teneurs par spectrométrie de masse à émission de plasma. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1998. http://dx.doi.org/10.4095/209534.