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Статті в журналах з теми "Spectrométrie de masse – Mesure"
Bourlés, Didier L., Quentin Simon, and Nicolas Thouveny. "La spectrométrie de masse par accélérateur." Reflets de la physique, no. 66 (July 2020): 16–21. http://dx.doi.org/10.1051/refdp/202066016.
Повний текст джерелаTemple, M. C., L. Bricaire, O. Barreau, N. Lahlou, and X. Bertagna. "Vers un test à la métopirone ambulatoire avec mesure du 11-désoxycortisol salivaire par spectrométrie de masse." Annales d'Endocrinologie 76, no. 4 (September 2015): 319. http://dx.doi.org/10.1016/j.ando.2015.07.089.
Повний текст джерелаBERDAGUE, J. L., and M. BONNEAU. "Mesure des nuisances olfactives associées à l’élevage porcin." INRAE Productions Animales 21, no. 4 (September 27, 2008): 361–66. http://dx.doi.org/10.20870/productions-animales.2008.21.4.3412.
Повний текст джерелаLEROULLEY, D., N. TAUDON, G. MILLIAT, B. ROEHRIG, J. LAUER, C. TOZZA, D. CABANE, and C. BOURRILHON. "Stabilité du méthoxyflurane au froid." Médecine et Armées Vol.49 No.2, Volume 49, Numéro 2 (June 21, 2023): 131–46. http://dx.doi.org/10.17184/eac.7788.
Повний текст джерелаSéby, Fabienne, Jean Dumont, Christine Gleyzes, Mathieu Menta, Véronique Vacchina, and Maïté Bueno. "Analyse de formes chimiques et de nanoparticules dans les échantillons d’eau : méthodes analytiques, préconcentration et validation." Revue des sciences de l’eau 28, no. 1 (April 21, 2015): 27–32. http://dx.doi.org/10.7202/1030004ar.
Повний текст джерелаBaglan, N., A. Amaral, C. Cossonnet, D. Franck, and J. Ritt. "Complémentarité des mesures nucléaires et de spectrométrie de masse, dans le cadre de l'analyse radiotoxicologique. Application aux urines et fèces." Radioprotection 32, no. 5 (December 1997): 673–83. http://dx.doi.org/10.1051/radiopro:1997125.
Повний текст джерелаLemire, F., M. Rouleau, M. Déry, B. Thériault, G. Dubois, P. Toren, D. Guérette, and F. Pouliot. "Importantes disparités entre les méthodes de mesure de la testostérone par spectrométrie de masse et par immunodosage en électrochemiluminescence chez les patients castrés atteints d’un cancer de la prostate : implications cliniques." Progrès en Urologie 28, no. 13 (November 2018): 612. http://dx.doi.org/10.1016/j.purol.2018.07.009.
Повний текст джерелаLoeber, J. Gerard, Dimitris Platis, Rolf H. Zetterström, and Peter J. C. I. Schielen. "Dépistage néonatal en Europe." médecine/sciences 37, no. 5 (May 2021): 441–56. http://dx.doi.org/10.1051/medsci/2021059.
Повний текст джерелаPapet, Yves. "Spectrométrie de masse." EMC - Biologie Médicale 1, no. 1 (January 2006): 1–3. http://dx.doi.org/10.1016/s2211-9698(06)76428-7.
Повний текст джерелаAdriaens, Annemie. "Spectrométrie de Masse." Analytica Chimica Acta 311, no. 2 (July 1995): 239. http://dx.doi.org/10.1016/0003-2670(95)90293-7.
Повний текст джерелаДисертації з теми "Spectrométrie de masse – Mesure"
Guigues, Elodie. "Mesure en ligne des produits de fission gazeux par spectrométrie de masse." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4706.
Повний текст джерелаIn order to increase fuel rod performances, the basic mechanisms that promote gas (i.e. He, H2, Kr and Xe) release from irradiated nuclear fuels must be studied. In this context, the CEA fuel study department at Cadarache decided to improve its experimental facility devoted to fuel behaviour under thermal transient by modifying the existing annealing device, called MERARG-II.The first part of this dissertation adresses the fuel gas release monitoring from irradiated fuel during thermal transient. The device choice leads to a quadrupole mass filter as mass analyser according to the specification requirement, i.e. isotopic identification of Xe, Kr and masses at 4 and 2 u. It is commercialized Residual Gas Analyser, mounted in a small-volume vacuum chamber requiring adaptations to be connected to the MERARG II line. The resolution and sensitivity of the mass spectrometer have been evaluated. The calibrated device is being installed in MERARG II replica.The second part of this dissertation relates adaptation to low-mass analysis of an RF 3D ion trap operated a Fourier Transform mode. Theoretically, using this operating mode, the lower the mass, the higher the resolution. More particularly, an ion injection device and its operating mode are studied in order to gain position and velocity distributions of confinable ions. The knowledge of these initial conditions is of a great concern as they fix the signal dynamic (peak height) and the signal fluctuation, respectively. This feasibility study, using simulation, allows us to obtain the optimal values of trap operating condition for 1-6 u mass injection and confinement with high resolution
Viale, Jean-Paul. "Mesure des échanges gazeux par spectrométrie de masse en anesthésie et en réanimation." Lyon 1, 1988. http://www.theses.fr/1988LYO1H076.
Повний текст джерелаCordeau, Emmanuelle. "Mesure d'interaction récepteur-ligand par marquage au sélénium et détection en spectrométrie de masse élémentaire." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTS006/document.
Повний текст джерелаMeasuring interactions between a drug candidate and its specific target constitutes a parameter of upmost importance in drug discovery process. Because of its robustness and very high sensitivity, radio-isotopic labeling represents up to now the reference method for these pharmacological studies. However, the use of radioactivity confers several constraints about security, health hazards and environmental issues involved by radioactive waste storage. Regarding such limitations, non-radioactive technologies have been developed principally based on fluorescence detection. But the cost of such assay as well as the fact that incorporation of a bulky fluorescent block can affect the affinity for small ligand limit their use. In this context, we aim to develop a new methodology to quantify receptor-ligands interactions. Mass spectrometry (MS) presents very interesting features in terms of detection sensitivity and specificity, making this technique a challenging analytical tool to replace radioactivity and fluorescence measurements commonly used in pharmacology. Among all MS technologies, the capacity of inductively coupled plasma-mass spectrometry (ICP-MS) to provide metallic and hetero elements absolute quantification, whatever the nature of the sample medium, prompted us to investigate this technique in combination with an appropriate labeling of the molecule of interest. Selenium was selected as a good compromise between ICP-MS response and chemical tagging ability through the creation of covalent bonds using conventional organic sulfur chemistry without disturbance of the affinity toward targeted receptor. Proof of concept was illustrated on the vasopressin receptor (V1A), a GPCR involved in vasoconstriction and emotional behavior and implying peptide as native ligand. Different strategies were applied to design selenium labeled peptides relying in either conventional amino acid substitution by corresponding selenium containing residue into peptide sequence such as cysteine (Cys) replacement by selenocysteine (Sec) as well as proline (Pro) by selenazolidine (Sez), or N-terminal peptide derivatization with a selenium containing small organic entity. ICP-MS analytical methodology was carefully investigated to provide sensitive and reliable selenium signal measurement. High inorganic salts contents of pharmacological buffer along with polyatomic interferences from plasma interfering selenium detection necessitate chromatographic separation and collision reaction cell equipment before ICP-MS detection. The pharmacological protocol was also adapted to the analytical requirements, in particular quantity of cells and sample handling. Robustness of the designed competitive binding assay was evaluated through the affinity constant (Ki) measurement of several known V1A-R ligands exhibiting either high or poor affinity for the receptor. Experimental values were strongly correlated to literature data, enabling to validate the proof of concept of such methodology and to propose a suitable alternative to radioactive labeling
Beucher, Charlotte. "Production et dissolution de la silice biogène dans les systèmes marins : Mesure par spectrométrie de masse." Brest, 2003. http://www.theses.fr/2003BRES2016.
Повний текст джерелаThis PhD thesis is part of the study of the biogeochemical cycle of silicon. This study aims to quantify production and dissolution rates of biosilica (BSiO2) in coastal and open ocean (the bay of Brest and the Southern Ocean). For that, an isotopic method (30Si as a tracer), using mass spectrometry, is developed. A time series (2 years, weekly sampling) of production and dissolution rates of biosilica (BSiO2), at SOMLIT/Brest station, shows a high seasonal variability. Annually, 50% of the biosilica produced in surface waters of the bay of Brest are regenerated. During productive period, the dissolution is related to BSiO2 production and to temperature. Comparatively to studies conducted in 1981 and 1993, a change of microphytoplankton dominance is observed in the Bay of Brest. Dinoflagellates out-compete diatoms from mid-August to end of October 2001 and during August 2002. Two hypotheses are proposed to explain the shift: a bottom-up control in 2001 and a top-down control in 2002. Measurements performed in the Indian-Pacific sector of the Southern Ocean, during summer 2003, reveal a total recycling of biosilica. Dissolution rates were not related to temperature but to percentage of dead diatoms. A correlation between integrated enzymatic protease activity of total bacteria and mean specific dissolution rate is observed for stations with high BSiO2 (> 100 mmol m-2). In the Southern Ocean, the synthesis of data about biosilica recycling show that the silicic acid pump can run into 3 modes and is more efficient during spring. The existence of such periods without silica-export must be considered both, in present and past primary production reconstruction
Albrieux, Florian. "Etude conformationnelle de peptides et protéines par mesure de mobilité ionique couplée à la spectrométrie de masse." Phd thesis, Université Claude Bernard - Lyon I, 2010. http://tel.archives-ouvertes.fr/tel-00594601.
Повний текст джерелаVieira, Nelson. "Mesure de la masse atomique du noyau N=Z, 74Rb, avec le spectromètre MISTRAL." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2002. http://tel.archives-ouvertes.fr/tel-00002578.
Повний текст джерелаCarette, Michel. "Etude expérimentale d'une source ionique par capture d'électrons d'atomes excités dans des états de Rydberg : application à la spectrométrie de masse de polluants atmosphériques." Aix-Marseille 1, 1999. http://www.theses.fr/1999AIX11065.
Повний текст джерелаAmaral, Ademir de Jesus. "Application de la spectrométrie de masse d'ions secondaires dans la détection et la mesure de l'uranium dans les milieux biologiques." Paris 12, 1997. http://www.theses.fr/1997PA120055.
Повний текст джерелаViera, Nelson. "Mesure de la masse atomique du noyau N=Z 74Rb avec le spectromètre MISTRAL." Paris 6, 2002. https://tel.archives-ouvertes.fr/tel-00002578.
Повний текст джерелаRossato, Maxime. "La dilution isotopique en spectrométrie de masse MALDI-ToF pour la mesure d’interactions entre récepteurs couplés aux protéines G et ligands peptidiques." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTS007/document.
Повний текст джерелаThe SID methodology, for Stable Isotope Dilution, is a widely applied methodology for peptides and proteins analysis in mass spectrometry, usually associated with atmospheric pressure ionisation techniques. This thesis is consequently devoted to the application of SID methodology in matrix assisted laser desorption/ionisation (MALDI) mass spectrometry to quantify receptor/ligand interaction in pharmacology. Indeed, a great number of pathologies involve membrane receptors like G protein coupled receptors (GPCR) in interaction with several ligands, frequently peptides. Particularly, the V1A receptor, is related to vasoconstriction activity of the peptide hormone AVP (arginine vasopressine) and contraction of muscular cells as well as many social behaviors. This receptor was chosen as model, requiring the chemical labelling of the ligand Homo-HO-LVA (Hydroxy Linear Vasopressin Antagonist), selected for its high affinity towards the V1A receptor in order to introduce the entity on which relies the quantification in SID/MALDI. This methodology is applied through the covalent binding of HCCA (4-hydroxy-α-cyanocinnamic acid) matrix, usually encountered in peptide analysis, to obtain the modified peptide (JMV4854) through N-terminal acylation. The objective is to take advantage of the use of both HCCA tagging and HCCE (4-hydroxy-α-cinnamic methyl ester) matrix for the specific and sensitive detection of compounds down to picomolar concentrations. Importantly, quantification with SID requires a calibration protocol and a statistical validation before pharmacological assays. This consists in the measurement of JMV4854 affinity towards V1A-R through thermodynamic experiments in order to quantify the dissociation constant (Kd) and determine afterwards constants for untagged molecules by competitive binding assays. Furthermore, a second receptor model, CCKB-R (cholecystokinine B receptor), was then studied to validate the quantification methodology. Facing the renewed interest in pharmaceutic industry of kinetic experiments for dissociation constant measurement, it would be interesting to apply this new methodology to drug discovery, representing a relevant alternative to current “gold-standard” methodologies such as radioactivity and fluorescence. A second field of research has been initiated with a covalent labelling designed to enhance peptide fragmentation for electrospray-based (ESI-MS/MS) tandem mass spectrometry measurements. Preliminary studies with the synthesis of pre-formed ions like N-terminal substitution with pyridinium entities gave very promising results opening the way of other quantification strategies
Книги з теми "Spectrométrie de masse – Mesure"
Constantin, Emilia. Spectrométrie de masse: Principes et applications. Paris: Technique et documentation-Lavoisier, 1986.
Знайти повний текст джерелаVincent, Stroobant, ed. Mass spectrometry: Principles and applications. 2nd ed. Chichester: Wiley, 2001.
Знайти повний текст джерелаVincent, Stroobant, ed. Mass spectrometry: Principles and applications. 3rd ed. Chichester, England: J. Wiley, 2007.
Знайти повний текст джерелаMass spectrometry: Principles and applications. Chichester: Wiley, 1996.
Знайти повний текст джерела1935-, Rosen Joseph D., ed. Applications of new mass spectrometry techniques in pesticide chemistry. New York: Wiley, 1987.
Знайти повний текст джерелаRosenberg. Mass spectrometry and gas chromatography. New Delhi, India: Rajat Publications, 2003.
Знайти повний текст джерелаMartin, Frearson, Prichard F. Elizabeth 1937-, and ACOL, eds. Mass spectrometry: Analytical chemistry by open learning. Chichester: Published on behalf of ACOL by Wiley, 1987.
Знайти повний текст джерелаB, Armentrout Peter, Caprioli R. M, and Gross Michael L, eds. Encyclopedia of mass spectrometry. San Diego, CA: Elsevier, 2003.
Знайти повний текст джерелаChristiane, Aubry, and Mayer Paul M. 1968-, eds. Assigning structures to ions in mass spectrometry. Boca Raton: CRC Press, 2007.
Знайти повний текст джерелаGiorgio, Montaudo, and Lattimer Robert, eds. Mass spectrometry of polymers. Boca Raton, Fla: CRC Press, 2002.
Знайти повний текст джерелаЧастини книг з теми "Spectrométrie de masse – Mesure"
Oppert, J. M. "Les phénotypes d’obésité: mesure de la masse adipeuse chez l’homme." In Physiologie et physiopathologie du tissu adipeux, 249–60. Paris: Springer Paris, 2013. http://dx.doi.org/10.1007/978-2-8178-0332-6_17.
Повний текст джерела"5. Spectrométrie de masse." In Les fondements de la détermination des structures moléculaires, 107–36. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-2152-5-007.
Повний текст джерела"5. Spectrométrie de masse." In Les fondements de la détermination des structures moléculaires, 107–36. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-2152-5.c007.
Повний текст джерелаGratuze, Bernard. "Application de la spectrométrie de masse à plasma." In Circulation et provenance des matériaux dans les sociétés anciennes, 243–72. Editions des archives contemporaines, 2014. http://dx.doi.org/10.17184/eac.4101.
Повний текст джерела"Chapitre 1 • Incertitude de mesure des radionucléides émetteurs alpha par spectrométrie." In Incertitudes de mesures, 1–38. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-0894-6-003.
Повний текст джерела"Chapitre 1 • Incertitude de mesure des radionucléides émetteurs alpha par spectrométrie." In Incertitudes de mesures, 1–38. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-0894-6.c003.
Повний текст джерелаЗвіти організацій з теми "Spectrométrie de masse – Mesure"
Arthaud, Marion. Mesure de la Masse Du Quark top dans le Canal Electron-Muon auprès du Détecteur D0 au TeVatron. Office of Scientific and Technical Information (OSTI), June 2008. http://dx.doi.org/10.2172/1415811.
Повний текст джерелаGueddari, K., M. R. LaFlèche, and J. Amossé. Extraction chimique des éléments du groupe du platine et de l'or et détermination de leurs teneurs par spectrométrie de masse à émission de plasma. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1998. http://dx.doi.org/10.4095/209534.
Повний текст джерелаCroc, Aurelien. Top quark mass measurement in the dilepton channel during the D0 experiment at the Tevatron. Mesure de la masse du quark top dans les canaux di-leptoniques auprès de l’expérience D0 au Tevatron. Office of Scientific and Technical Information (OSTI), January 2011. http://dx.doi.org/10.2172/1247702.
Повний текст джерела