Готові списки джерел за темами / Sham Prescription

Добірка наукової літератури з теми "Sham Prescription"

Автор: Grafiati
Опубліковано: 7 вересня 2023

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Статті в журналах з теми "Sham Prescription"

1

Chae, Han-Jung, Dong-Hyeon Yun, Hee-Young Chin, Sim-Keum Yoo, Hyung-Min Kim, Song-Baeg Kim, and Hyung-Ryong Kim. "Effect of Dang-Gui-Ji-Hwang-Yeum on Osteoporosis in Ovariectomized Rats." American Journal of Chinese Medicine 32, no. 03 (January 2004): 351–60. http://dx.doi.org/10.1142/s0192415x04002004.

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Анотація:
Dang-Gui-Ji-Hwang Yeum (DGJHY; an Oriental prescription), has been successfully used for the management of osteoporotic disorders in China, Japan and Korea. In this study, we have characterized the effect of DGJHY on osteoporosis-associated phenomena in ovariectomized (OVX) rats by measuring body weights and bone histomorphometries in sham, OVX and DGJHY-administered OVX rats. Light microscopic analyses showed a porous or an eroded appearance on the tibial trabecular bone surface in OVX rats, whereas those of the sham and DGJHY-administered OVX rats were composed of fine particles. The trabecular bone area and the trabecular thickness in OVX rats were significantly lower than those of sham rats. Moreover, these reductions in OVX rats were significantly reversed by the administration of DGJHY for 7 weeks, and osteoclast numbers were also significantly reduced. Although no differences were observed between OVX and DGJHY-administered OVX rats and the sham animals at the T 3 level, we have found significant differences between these two groups at the T 4 level. However, serum phosphorus, calcium, mechanical strength and the surface appearance of osteoblasts in the DGJHY-administered OVX rats were similar to those of OVX rats. These results suggest that DGJHY is effective at preventing bone loss in OVX rats.
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2

Park, In Sil, Hye Won Lee, Jin Ah Ryuk, and Byoung Seob Ko. "Effects of an Aqueous Extract of Dangguijagyagsan on Serum Lipid Levels and Blood Flow Improvement in Ovariectomized Rats." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/497836.

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Dangguijagyagsan (DJS), a traditional herbal prescription, has long been used to treat menopause-related symptoms. We identified the cardioprotective effects of an aqueous extract of DJS using an ovariectomized (OVX) and ferric chloride- (FeCl-) induced carotid thrombosis rat model. Female Sprague-Dawley (SD) rats were ovariectomized or Sham-operated (Sham-control). The ovariectomized rats were divided into three groups: OVX with saline (OVX-control), aspirin 30 mg/kg/day (OVX-ASA), and DJS 100 mg/kg/day (OVX-DJS). The treatments were administered for 5 weeks. Then, blood samples were collected to analyze the serum lipid levels and platelet aggregation. The topical application of 40% FeCl3induced intravascular thrombosis, which was used to test thrombotic occlusion and for histological examination. Body weight and the levels of total cholesterol (TC), triglyceride (TG), and LDL-cholesterol (LDL-C) increased in the OVX rats. These effects were reduced by ASA and DJS treatment. In addition, ASA and DJS treatment significantly inhibited platelet aggregation. These treatments also increased time to occlusion and decreased both thrombus size and the presence of collagen fibers in surrounding vessel walls compared with the Sham-control and OVX-control groups. These results suggest that DJS has beneficial effects in terms of preventing cardiovascular disease in menopausal woman because it can reduce the serum lipid levels and improve blood flow by inhibiting platelet aggregation and thrombus formation.
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3

Crew, K. D., J. Capodice, H. Greenlee, L. Brafman, D. Fuentes, D. Awad, and D. L. Hershman. "Randomized, blinded, placebo-controlled trial of acupuncture for the management of aromatase inhibitor-associated joint symptoms in women with early-stage breast cancer." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 571. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.571.

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571 Background: Aromatase inhibitors (AIs) have become the standard of care for the treatment of postmenopausal, hormone-sensitive breast cancer (BC). However, patients receiving AIs may experience joint symptoms which can lead to early discontinuation of this effective therapy. We examined whether acupuncture improves AI-induced arthralgias in women with early stage BC. Methods: This study is a randomized, single-blinded trial of true vs sham acupuncture twice weekly for 6 weeks in postmenopuasal women with early stage BC and self-reported musculoskeletal pain related to adjuvant AI therapy. The active intervention included full body/auricular acupuncture and a joint-specific point prescription, whereas the sham arm involved superficial needle insertion at nonacupoint locations. Outcome measures included the Brief Pain Inventory-Short Form (BPI-SF), Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC), and Modified Score for the Assessment and Quantification of Chronic Rheumatoid Affections of the Hands (M-SACRAH) obtained at baseline, 3 and 6 weeks. Lower scores reflect improvement in symptoms. Results: Of 43 women enrolled, 38 were evaluable at 6 weeks. Baseline characteristics were comparable between the groups. Median age: 57 (37–77); White/Hispanic/Black/Asian: 15/21/1/1; median body mass index (kg/m2): 29 (18–45). True acupuncture was associated with about a 50% decrease in mean BPI-SF scores, whereas no change from baseline was observed for the sham acupuncture group (see table). Similar findings were seen for the WOMAC and M-SACRAH pain, stiffness, and function scores (P<0.05). No adverse events were reported. Conclusions: Women with AI-induced arthralgias treated with acupuncture had significant improvement of joint pain and stiffness, which was not seen with sham acupuncture. Acupuncture is an effective and well-tolerated strategy for managing this common treatment-related side effect. [Table: see text] No significant financial relationships to disclose.
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4

Radavi-Asgar, Maryam, Nazanin Sabet, Mohammad Khaksari, Elham Jafari, Zahra Soltani, and Fatemeh Dehghanian. "The Prescription of Oral Mucosal Mesenchymal Stem Cells post-Traumatic Brain Injury Improved the Kidney and Heart Inflammation and Oxidative Stress." BioMed Research International 2022 (November 10, 2022): 1–12. http://dx.doi.org/10.1155/2022/8235961.

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Анотація:
Background. In the last years, mesenchymal stem cells (MSCs) have been considered as a useful strategy to treat many diseases such as traumatic brain injury (TBI). The production of inflammatory agents by TBI elicits an inflammatory response directed to other systems of body, such as the heart and the kidneys. In this study, the efficacy of oral mucosal mesenchymal stem cells (OMSCs) prescription after TBI in inflammation and oxidative stress of the heart and kidneys was evaluated. Methods. Twenty-four male rats were located in groups as follows: sham, TBI, vehicle (Veh), and stem cell (SC). OMSCs were injected intravenously 1 and 24 hours after TBI. Inflammatory, oxidative stress, and histopathological outcomes of the heart and kidney tissues were investigated 48 hours after TBI. Results. TBI caused an increase in the level of interleukin-1β (IL-1β), interleukin-6 (IL-6), malondialdehyde (MDA), and carbonyl protein (PC) of the heart and kidney compared to the sham group. Superoxide dismutase (SOD), total antioxidant capacity (TAC), catalase (CAT), and interleukin-10 (IL-10) of the heart and kidney decreased after TBI. The use of OMSCs after TBI reduced the changes of these factors in both the heart and the kidney. Conclusion. Application of OMSCs after TBI can decrease inflammation and oxidative stress of the heart and kidney tissues leading to the reduction of damage. Therefore, this method can be evaluated in the TBI patients in future studies.
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5

Siemens, Waldemar, Christopher Boehlke, Michael I. Bennett, Klaus Offner, Gerhild Becker, and Jan Gaertner. "Transcutaneous electrical nerve stimulation for advanced cancer pain inpatients in specialist palliative care—a blinded, randomized, sham-controlled pilot cross-over trial." Supportive Care in Cancer 28, no. 11 (March 3, 2020): 5323–33. http://dx.doi.org/10.1007/s00520-020-05370-8.

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Abstract Purpose Transcutaneous electrical nerve stimulation (TENS) is a treatment option for cancer pain, but the evidence is inconclusive. We aimed to evaluate the efficacy and safety of TENS. Methods A blinded, randomized, sham-controlled pilot cross-over trial (NCT02655289) was conducted on an inpatient specialist palliative care ward. We included adult inpatients with cancer pain ≥ 3 on an 11-point numerical rating scale (NRS). Intensity-modulated high TENS (IMT) was compared with placebo TENS (PBT). Patients used both modes according to their preferred application scheme during 24 h with a 24-h washout phase. The primary outcome was change in average pain intensity on the NRS during the preceding 24 h. Responders were patients with at least a “slight improvement.” Results Of 632 patients screened, 25 were randomized (sequence IMT-PBT = 13 and PBT-IMT = 12). Finally, 11 patients in IMT-PBT and 9 in PBT-IMT completed the study (N = 20). The primary outcome did not differ between groups (IMT minus PBT: − 0.2, 95% confidence interval − 0.9 to 0.6). However, responder rates were higher in IMT (17/20 [85%] vs. 10/20 [50%], p = 0.0428). Two patients experienced an uncomfortable feeling caused by the current, one after IMT and one after PBT. Seven patients (35%) desired a TENS prescription. Women and patients with incident pain were most likely to benefit from TENS. Conclusion TENS was safe, but IMT was unlikely to offer more analgesic effects than PBT. Even though many patients desired a TENS prescription, 50% still reported at least “slight pain relief” from PBT. Differences for gender and incident pain aspects demand future trials.
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6

Lan, Rui, Jun Xiang, Guo-Hua Wang, Wen-Wei Li, Wen Zhang, Li-Li Xu, and Ding-Fang Cai. "Xiao-Xu-MingDecoction Protects against Blood-Brain Barrier Disruption and Neurological Injury Induced by Cerebral Ischemia and Reperfusion in Rats." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/629782.

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Xiao-Xu-Mingdecoction (XXMD) is an effective prescription in the treatment of ischemic stroke, but the mechanisms involved are not well known. In the present study, 120 male Sprague-Dawley rats were randomly divided into 5 groups: sham control (sham), ischemia and reperfusion (IR), and IR plus 15, 30, and 60 g/kg/day XXMD. The stroke model was induced by 90 min of middle cerebral artery occlusion followed by reperfusion. The brain lesion areas were evaluated by 2,3,5-triphenyltetrazolium chloride staining, and neurological deficits were observed at different time points after reperfusion. Blood-brain barrier (BBB) disruption was evaluated by assessing brain water content and Evans blue content. Pathological changes in BBB ultrastructure were observed with transmission electron microscopy. MMP-9, -2, and VEGF expression levels were quantitatively determined by western blotting and immunohistochemistry. We found that XXMD (60 g/kg/day) treatment reduced cerebral infarct area, improved behavioral function, and attenuated ultrastructure damage and permeability of BBB following ischemia and reperfusion. Moreover, XXMD downregulated the expression levels of MMP-9, -2, and VEGF. These findings indicate that XXMD alleviates BBB disruption and cerebral ischemic injury, which may be achieved by inhibiting the expression of MMP-9, -2, and VEGF.
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7

Bai, Wen-Wu, Yi-Fan Xing, Bo Wang, Xiao-Ting Lu, Ying-Bin Wang, Yuan-Yuan Sun, Xiao-Qiong Liu, Tao Guo, and Yu-Xia Zhao. "Tongxinluo Improves Cardiac Function and Ameliorates Ventricular Remodeling in Mice Model of Myocardial Infarction through Enhancing Angiogenesis." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/813247.

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Background. Myocardial infarction (MI) is a major cause of morbidity and mortality in the world. Tongxinluo (TXL) is a traditional Chinese compound prescription which has cardioprotective functions. The present study was aimed to determine the effect of TXL on postischemic cardiac dysfunction and cardiac remodeling and to elucidate the underlying mechanisms.Methods and Results. MI was performed by ligation of left anterior descending coronary artery (LAD) in male adult mice. Mice were randomly divided into four groups: (1) sham group (Sham); (2) MI-control group (Control); (3) MI-low dose TXL group (TXL-L); and (4) MI-high dose TXL (TXL-H) group. Compared with the control group, TXL treatment restored cardiac function, increased revascularization, attenuated cardiomyocyte apoptosis, and reduced interstitial fibrosis. TXL treatment increased the phosphorylation of Akt, extracellular signal regulated kinase (ERK), and endothelial nitric oxide synthase (eNOS); the expression of phosphatidylinositol3-kinase (PI3K), hypoxia-inducible factors 1α(HIF-1α), and vascular endothelial growth factor (VEGF); and the DNA binding activity of HIF-1αafter MI.Conclusion. TXL may improve cardiac function and ameliorate cardiac remodeling by increasing neovascularization through enhancing the phosphorylation of Akt and ERK, the expression and activity of HIF-1α, and the protein level of VEGF and p-eNOS.
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8

Vasconcelos-Filho, Francisco S. L., Roberta C. da Rocha-e-Silva, Jonathan E. R. Martins, Welton D. N. Godinho, Vitor V. da Costa, Jannison K. C. Ribeiro, Carlos A. da Silva, Vania M. Ceccatto, Paula M. Soares та Janaina S. A. M. Evangelista. "Neuroprotector Effect of Daily 8-Minutes of High-Intensity Interval Training in Rat Aβ1-42 Alzheimer Disease Model". Current Alzheimer Research 17, № 14 (5 березня 2021): 1320–33. http://dx.doi.org/10.2174/1567205018666210218161856.

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Background: Alzheimer’s disease (AD) is the most common and irreversible neurodegenerative disorder, and amyloid peptide plays a central role in its pathogenesis. Physical training contributes as a beneficial adaptation to AD. However, these effects may be underestimated because much of the literature used fixed training prescription variables (intensity and volume) throughout the protocol. Moreover, researchers poorly understand whether chronic high-intensity interval training (HIIT) exerts similar effects on the brain tissue of individuals with AD. Objective: This study evaluated the effect of 8 minutes of HIIT with incremental overload in an AD model. Methods: Forty male Wistar rats were divided into four groups: an untrained Sham group, Sham trained group, Aβ1-42 (Alzheimer’s) untrained group, and Aβ1-42 (Alzheimer’s) trained group (n=10 rats per group). Animals underwent stereotactic surgery and received a hippocampal injection of Aβ1-42 or a saline solution. Seven days after surgery, two weeks of treadmill adaptation followed by a maximal running test (MRT) was performed. Then, animals were subjected to eight weeks of HIIT. Rats were sacrificed 24 h after the behavioral tests (open field and Morris water maze), hippocampal tissue was extracted to analyze the redox balance and BDNF/TrkB pathway, and neuritic plaques (NP) were detected by evaluating silver impregnation. Results: The AD trained group presented a physical capacity amelioration every two weeks and locomotor, learning, and memory improvements (p<0.05). These effects were accompanied by increased CAT and SOD levels, followed by decreased lipid peroxidation (p<0.05). Furthermore, increased activation of the BDNF/TrkB (p<0.05) pathway and decreased NP was observed. Conclusions: Based on these results, MRT was essential for an excellent chronic training protocol prescription and overload adjustment. Therefore, 8 minutes of HIIT daily for 8 weeks may reduce behavioral deficits by promoting a positive redox balance and increased activity of the BDNF/TrkB pathway that may contribute to NP attenuation.
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9

Lee, Subum, Dae-Chul Cho, Kyong-Tae Kim, and Young-Seok Lee. "Evidence-based treatment of osteoporotic vertebral compression fracture." Journal of the Korean Medical Association 64, no. 3 (March 10, 2021): 200–207. http://dx.doi.org/10.5124/jkma.2021.64.3.200.

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The prevalence and medical costs of osteoporotic vertebral compression fractures (OVCFs) are on the rise. However, a concrete evidence-based treatment guideline has not yet been established. Despite that numerous randomized controlled trials (RCTs) were performed, the study design and outcome measurement were heterogeneous, and the results were not unified. The purpose of this review is to compare the results of high level-evidence studies to provide a background for evidence-based OVCF treatment. Many reports showed that vertebroplasty has better clinical outcomes than non-surgical treatment for OVCF, but the results of three double-blinded RCTs with the highest level of evidence did not show a significant difference between vertebroplasty and sham procedure. Whether undergoing surgical or non-surgical treatment, OVCF patient management should be started by managing osteoporosis first. Meanwhile, in the results of RCTs related to the comparison of conservative treatment modalities, the benefit of braces and a specific analgesic prescription protocol was also unclear. The presented results of each clinical trial were generally inconsistent and may not be appropriate in all situations. Any decision by clinicians to apply this evidence must be made considering individual patients and available resources. At present, controversy remains about the best treatment modality for OVCF. Large, multicenter, placebo/sham-controlled trials are needed to address this gap and establish strong evidence-based guidelines.
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10

Zhang, Meng-yun, Hui-hua Chen, Jing Tian, Hui-juan Chen, Ling-ling Zhu, Pei Zhao, and Ting Zhang. "Danggui Shaoyao San Ameliorates Renal Fibrosis via Regulation of Hypoxia and Autophagy." Evidence-Based Complementary and Alternative Medicine 2019 (March 17, 2019): 1–10. http://dx.doi.org/10.1155/2019/2985270.

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Danggui Shaoyao San (DSS), a traditional Chinese medicinal prescription, was widely used to reinforce earth to activate collaterals in ancient times. Recently, many clinical studies found that DSS had a renoprotection. In this study, we evaluated the effect of DSS on unilateral ureteral obstruction- (UUO-) induced renal fibrosis in rats and investigated the mechanisms underlying the effect. Sprague Dawley (SD) rats were randomized to UUO or Sham operation. After 1 day, the rats that underwent UUO were randomized to treatment for four experimental groups (n=10 each group): Sham, UUO only, UUO+ benazepril (Bena), and UUO+DSS. After 4 weeks, we demonstrated that DSS significantly suppressed UUO-induced renal hypertrophy by gravimetric. In addition, DSS obviously prevented UUO-induced disorder in renal structure and renal function by HE and biochemistry test. We also found that DSS abrogated UUO-induced renal fibrosis by Masson’s staining and collagen volume fraction (CVF) analysis; this is consistent with the western blot analysis that showed DSS abrogated the UUO-induced enhanced TGF-β1 and weakened BMP-7. Compared with the UUO only group, rats treated with DSS exhibited significant increase in vascular density, followed by decrease in hypoxia and HIF-1α protein level through western blot and immunofluorescence analysis. Furthermore, we also determined proteins of autophagy and DSS enhanced autophagy to prevent the damage-induced by UUO. Taken together, our findings demonstrated that DSS had a renoprotection effect in ameliorating renal fibrosis possibly via attenuating tissue hypoxia and regulating autophagy.
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Дисертації з теми "Sham Prescription"

1

Fan, Zheng-Hong, and 范政鴻. "Explore the different decoction methods of traditional prescriptions on Shao Yao Gan Cao Tang." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/7pe8tq.

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2

YU-HEI, CHEN, and 陳宇輝. "Comparative studies of jaundice pattern prescriptions from Shan-Han-Lun, Jin-Gui-Yao-Lueh andWen-Bing-Tian-Bian on experimental hepatitis with jaundice induced by ANIT." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/74092324391632884942.

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Анотація:
碩士
中國醫藥學院
中國醫學研究所
88
The purpose of the study is to deal with the prescriptions for curing Jaundice in Shan-Han-Lun, Jin-Gui-Yao-Lueh and Wen-Bing-Tian-Bian, comparing their choleretic and anti-liver damage effects, in treating ANIT-induced experimental cholangiolitic hepatitis of Jaundice in Rats, and, by means of Jonker’s pathologically semi-quantitative analysis to observe and compare how these prescriptions can make improvement in the model’s pathological lesion. The results demonstrate that: (1)in Shan-Han-Lun, when the dosage is 1g/kg, Zhi-Zi-Bo-Pi Tang(ZBT) has the best effect on improving liver cell damage and bile dust obstruction; when the dosage is 2g/kg, Ma-Huang-Lian-Qiao-Chi-Xiao-Dou Tang(MLT) and Yin-Chen-Hao Tang (YCT) have the effect of anti-liver damage, but ZBT cought make liver toxicity and hemolysis, therefore, the best dosage of the prescription is worth to research. (2)in Jin-Gui-Yao-Lueh, when the dosage is 1g/kg, Zhi-Zi-Da-Huang Tang(ZDT), Yin-Chen-Wu-Ling San(YWS) and Da-Huang-Xiao-Shi Tang(DXT) can make improvement of liver damage and choleretic effect, only the YWS can make improvement of bile dust obstruction; when the dosage is 2g/kg, the treatment effects of these prescriptions are better then the dosage is 1g/kg. Among these prescriptions, the best effect of treatment is DXT. Pathologically, the main protective effect of liver damage may because of attenuation of PMN infiltration to inhibit the liver damage. (3)in Wen-Bing-Tian-Bian, when the dosage is 1g/kg, Er-Jin Tang(EJT), Xing-Ren-Shi-Gao Tang(XST) and Lian-Qiao-Chi-Xiao-Dou Yin(LCY) can make improvement of liver damage, LCY has the best effect among three prescriptions and can make improvement of bile duct obstruction. Pathologically, the main effects are on attenuation of liver cell inflammation and PMN infiltration; when the dosage is 2g/kg, among these prescriptions, LCY has the best effect on improvement of liver damage, choleretic and bile duct obstruction. Pathologically, on the main protective effect of liver damage, XST and LCY can make improvement of liver cell inflammation and tissue necrosis.
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Книги з теми "Sham Prescription"

1

Fa, Su, ed. Shao lin yi yao mi chuan. Taibei Shi: He xi wen hua shi ye gu fen you xian gong si, 1995.

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2

Shixi, He, He Qiwei 1774-1837, and Wang Ang 1615-, eds. Shan ding yi fang Tang tou ge jue. Shanghai: Xue lin chu ban she, 1987.

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3

Mei rong shou shen yao shan: Mei rong shou shen yao shan. Chengdu: Sichuan ke xue ji shu chu ban she, 2001.

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4

Chaoliang, Zhang, ed. Guangxi shao shu min zu chang jian bing bian fang xuan. [Nanning]: Guangxi min zu chu ban she, 1985.

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5

Huang, Dunyan. Su shi jian kang yao shan zhou. Taibei Shi: Rui sheng wen hua tu shu shi ye you xian gong si, 1989.

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6

editor, Hu Guojun, and Hu Shiyun editor, eds. Ju jing yi shao: Si shi chang jian gan zheng qiu jing. Beijing: Xue yuan chu ban she, 2013.

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7

Tinghua, Luo, Yu Junsheng, and Guizhou Sheng min zu shi wu wei yuan hui. Wen jiao chu., eds. Guizhou shao shu min zu yao wu ji. Guiyang Shi: Guizhou min zu chu ban she, 1990.

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8

author, Niu Linjing editor, ed. Zhong yi jing dian yao shan da quan. Shanghai: Shanghai ke xue pu ji chu ban she, 2018.

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9

Lijuan, Zhou, ed. Zeng qiang jing li, huo li yao shan. Taibei Shi: Guo ji cun wen ku shu dian you xian gong si, 1995.

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10

Dehong shi ju shao shu min zu yi yao gai guan. Kunming Shi: Yunnan da xue chu ban she, 2012.

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Частини книг з теми "Sham Prescription"

1

Wixson, Christopher. "Prescription and Petrifaction: Proprietary Medicine, Health Marketing, and Misalliance." In Bernard Shaw and Modern Advertising, 31–57. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-78628-5_2.

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