Добірка наукової літератури з теми "RNA therapeutic"
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Статті в журналах з теми "RNA therapeutic"
Mahy, BWJ. "Therapeutic RNA?" Reviews in Medical Virology 15, no. 6 (2005): 349–50. http://dx.doi.org/10.1002/rmv.485.
Повний текст джерелаLiu, Xiang, Yu Zhang, Shurong Zhou, Lauren Dain, Lei Mei, and Guizhi Zhu. "Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines." Journal of Controlled Release 348 (August 2022): 84–94. http://dx.doi.org/10.1016/j.jconrel.2022.05.043.
Повний текст джерелаEVERTS, SARAH. "RNA DISTRACTION IS THERAPEUTIC." Chemical & Engineering News 87, no. 29 (July 20, 2009): 15. http://dx.doi.org/10.1021/cen-v087n029.p015a.
Повний текст джерелаPoller, Wolfgang, Juliane Tank, Carsten Skurk, and Martina Gast. "Cardiovascular RNA Interference Therapy." Circulation Research 113, no. 5 (August 16, 2013): 588–602. http://dx.doi.org/10.1161/circresaha.113.301056.
Повний текст джерела&NA;. "Therapeutic potential of RNA??interference." Inpharma Weekly &NA;, no. 1411 (November 2003): 2. http://dx.doi.org/10.2165/00128413-200314110-00001.
Повний текст джерелаStevenson, Mario. "Therapeutic Potential of RNA Interference." New England Journal of Medicine 351, no. 17 (October 21, 2004): 1772–77. http://dx.doi.org/10.1056/nejmra045004.
Повний текст джерелаHan, Xuexiang, Michael J. Mitchell, and Guangjun Nie. "Nanomaterials for Therapeutic RNA Delivery." Matter 3, no. 6 (December 2020): 1948–75. http://dx.doi.org/10.1016/j.matt.2020.09.020.
Повний текст джерелаSioud, Mouldy, and Marianne Leirdal. "Therapeutic RNA and DNA enzymes." Biochemical Pharmacology 60, no. 8 (October 2000): 1023–26. http://dx.doi.org/10.1016/s0006-2952(00)00395-6.
Повний текст джерелаNovina, C. D. "Therapeutic potential of RNA interference." Biomedicine & Pharmacotherapy 58, no. 4 (May 2004): 270. http://dx.doi.org/10.1016/j.biopha.2002.12.001.
Повний текст джерелаvan Ommen, Gert-Jan B., and Annemieke Aartsma-Rus. "Advances in therapeutic RNA-targeting." New Biotechnology 30, no. 3 (March 2013): 299–301. http://dx.doi.org/10.1016/j.nbt.2013.01.005.
Повний текст джерелаДисертації з теми "RNA therapeutic"
Kavitha, Siva. "RNA-based therapeutic approaches for FTDP-17." Doctoral thesis, Università degli studi di Trento, 2015. https://hdl.handle.net/11572/367651.
Повний текст джерелаKavitha, Siva. "RNA-based therapeutic approaches for FTDP-17." Doctoral thesis, University of Trento, 2015. http://eprints-phd.biblio.unitn.it/1552/1/PhD_thesis_Siva_K_June_2015.pdf.
Повний текст джерелаWhite, Melanie Denise. "RNA interference as a therapeutic approach in prion disease." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1445182/.
Повний текст джерелаWu, Connie Ph D. Massachusetts Institute of Technology. "Engineering periodic short hairpin RNA delivery systems for enhanced therapeutic efficacy." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/121821.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references.
RNA interference (RNAi) presents a highly promising approach for cancer therapeutics via specific silencing of disease-implicated genes, but its clinical translation remains severely limited by barriers in delivering short interfering RNA (siRNA). Numerous delivery vehicles have been developed to protect siRNA from degradation, promote target cell uptake, and facilitate endosomal escape into the cytoplasm, where RNAi occurs. However, in vivo instability, low silencing efficiency, undesired toxicity, and immunogenicity remain challenges for current siRNA delivery systems, particularly as the low valency and high rigidity of siRNA make it difficult to condense into stable nanoparticles. Here we engineer the siRNA cargo to make it more amenable to stable encapsulation by using a polymeric form of siRNA, or periodic short hairpin RNA (p-shRNA), as well as design a biodegradable polycationic carrier for efficient in vivo delivery of p-shRNA.
Consisting of tens of linked siRNA repeats, p-shRNA is synthesized by the repeated action of T7 RNA polymerase around a circular DNA template. We first leverage molecular engineering design an open-ended p-shRNA structure that is efficiently processed inside cells into siRNAs, greatly enhancing its silencing potency. Furthermore, the much higher valency and flexibility of p-shRNA compared to siRNA enable more stable complexation with delivery materials. To exploit these advantages of p-shRNA, we optimize biodegradable polycations with hydrophobic regions that promote stable condensation and efficient intracellular release. Our approach unveils key design rules governing p-shRNA delivery, and we develop stabilized p-shRNA complexes that show in vivo therapeutic efficacy in a syngeneic melanoma mouse model. Finally, we extend our p-shRNA platform to act as a dual therapeutic agent, harnessing innate immune activation together with gene silencing.
By modulating the surface of the p-shRNA complexes with an anionic polypeptide, we dramatically enhance innate immune recognition of p-shRNA by pattern recognition receptors while maintaining high silencing efficiency. These dually acting complexes can target ovarian tumors in vivo and prolong survival in a syngeneic ovarian cancer mouse model. Our findings establish a potent, multifunctional RNAi platform that can potentially move RNAi therapeutics closer to clinical translation by addressing the delivery and in vivo efficacy challenges faced by current siRNA systems.
National Science Foundation Graduate Research Fellowshipgrant #1122374
Koch Institute Ludwig Center for Molecular Oncology Graduate Fellowship
Congressionally Directed Medical Research Program Ovarian Cancer Research Program Teal Innovator Award from the Department of Defense (13-1-0151)
by Connie Wu.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Chemical Engineering
BALESTRA, Dario. "Modified U1snRNAs as innovative therapeutic strategy for inherited coagulation factor deficiencies." Doctoral thesis, Università degli studi di Ferrara, 2012. http://hdl.handle.net/11392/2388781.
Повний текст джерелаAl-Mazedi, Maryam. "A therapeutic approach to chronic myeloid leukaemia using short hairpin RNA molecules." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/a-therapeutic-approach-to-chronic-myeloid-leukaemia-using-short-hairpin-rna-molecules(185139fb-ed9b-46d7-a5a8-04532c44640b).html.
Повний текст джерелаJubair, Luqman Khaleel. "Next-Generation Cancer Therapies: The Therapeutic Potential of RNA-Directed Gene-Editing." Thesis, Griffith University, 2018. http://hdl.handle.net/10072/382679.
Повний текст джерелаThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medical Science
Griffith Health
Full Text
Elmén, Joacim. "Nucleic acid based therapeutic approaches /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-047-8/.
Повний текст джерелаHong, Lingzi. "Act1-Mediated RNA Metabolism in IL-17-Driven Inflammatory Diseases." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case162673878106271.
Повний текст джерелаChitiprolu, Maneka. "Novel Regulatory Mechanisms of Autophagy in Human Disease: Implications for the Development of Therapeutic Strategies." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38441.
Повний текст джерелаКниги з теми "RNA therapeutic"
A, Mulligan James. MicroRNA: Expression, detection, and therapeutic strategies. New York: Nova Science, 2011.
Знайти повний текст джерелаSioud, Mouldy. RNA interference: Challenges and therapeutic opportunities. New York: Humana Press, 2015.
Знайти повний текст джерелаHiroshi, Takaku, and Yamamoto Naoki 1945-, eds. RNAi therapeutics, 2006. Trivandrum, Kerala, India: Transworld Research Network, 2006.
Знайти повний текст джерелаArbuthnot, Patrick, and Marc S. Weinberg. Applied RNAi: From fundamental research to therapeutic applications. Norfolk, UK: Caister Academic Press, 2014.
Знайти повний текст джерелаRNA therapeutics: Function, design, and delivery. New York: Humana Press, 2010.
Знайти повний текст джерелаYasko, Amy. Heal your body naturally: The power of RNA. [United States]: Matrix Development Pub., 2004.
Знайти повний текст джерела1947-, Scanlon Kevin J., ed. Therapeutic applications of ribozymes. Totowa, N.J: Humana Press, 1998.
Знайти повний текст джерелаTherapeutic applications of ribozymes and riboswitches: Methods and protocols. New York: Humana Press, 2014.
Знайти повний текст джерелаThomas, Tuschl, Rossi John J, and New York Academy of Sciences, eds. Oligonucleotide therapeutics. Boston, Mass: Blackwell on behalf of the New York Academy of Sciences, 2006.
Знайти повний текст джерела1922-, Weiss Benjamin, ed. Antisense oligodeoxynucleotides and antisense RNA: Novel pharmacological and therapeutic agents. Roca Raton, Fla: CRC Press, 1997.
Знайти повний текст джерелаЧастини книг з теми "RNA therapeutic"
Kang, Moo Rim, Gongcheng Li, Tiejun Pan, Jin-Chun Xing, and Long-Cheng Li. "Development of Therapeutic dsP21-322 for Cancer Treatment." In RNA Activation, 217–29. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4310-9_16.
Повний текст джерелаSioud, Mouldy. "RNA Interference: Mechanisms, Technical Challenges, and Therapeutic Opportunities." In RNA Interference, 1–15. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1538-5_1.
Повний текст джерелаIversen, Per Ole, and Mouldy Sioud. "Engineering Therapeutic Cancer Vaccines That Activate Antitumor Immunity." In RNA Interference, 263–68. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1538-5_15.
Повний текст джерелаPierce, Jacob B., Haoyang Zhou, Viorel Simion, and Mark W. Feinberg. "Long Noncoding RNAs as Therapeutic Targets." In Long Noncoding RNA, 161–75. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92034-0_9.
Повний текст джерелаSeth, Shaguna, Michael V. Templin, Gregory Severson, and Oleksandr Baturevych. "A Potential Therapeutic for Pandemic Influenza Using RNA Interference." In RNA Interference, 397–422. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-588-0_26.
Повний текст джерелаGuha, Shalini, Priyanka Barman, Aruniti Manawa, and Sukesh R. Bhaumik. "Nuclear Export of mRNAs with Disease Pathogenesis and Therapeutic Implications." In RNA Technologies, 371–95. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08415-7_17.
Повний текст джерелаCheng, Yi, Dong Zhang, Travis Hurst, Xiaoqin Zou, Paloma H. Giangrande, and Shi-Jie Chen. "RNA Structural Modeling for Therapeutic Applications." In RNA Nanotechnology and Therapeutics, 447–61. 2nd ed. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003001560-47.
Повний текст джерелаYoo, Ji Young, Balveen Kaur, Tae Jin Lee, and Peixuan Guo. "MicroRNAs in Human Cancers and Therapeutic Applications." In RNA Nanotechnology and Therapeutics, 529–42. 2nd ed. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003001560-54.
Повний текст джерелаSzymański, Maciej, and Jan Barciszewski. "Noncoding RNAs as Therapeutic Targets." In RNA Technologies and Their Applications, 393–418. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-12168-5_18.
Повний текст джерелаAkaneya, Yukio. "A New Approach for Therapeutic Use by RNA Interference in the Brain." In RNA Interference, 313–24. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-588-0_20.
Повний текст джерелаТези доповідей конференцій з теми "RNA therapeutic"
Ke, Yonggang, DongMoon Shin, and Georgia Chen. "Abstract 3635: RNA-based nanostructures for therapeutic siRNA delivery." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-3635.
Повний текст джерелаKe, Yonggang, DongMoon Shin, and Georgia Chen. "Abstract 3635: RNA-based nanostructures for therapeutic siRNA delivery." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-3635.
Повний текст джерелаEndo-Takahashi, Yoko, Yoichi Negishi, Ryo Suzuki, Kazuo Maruyama, Yukihiko Aramaki, Yoichiro Matsumoto, Lawrence A. Crum, and Gail Reinette ter Haar. "Novel siRNA-loaded Bubble Liposomes with Ultrasound Exposure for RNA Interference." In 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010). AIP, 2011. http://dx.doi.org/10.1063/1.3607930.
Повний текст джерелаLoeb, David M., Breelyn A. Wilky, Catherine Kim, Elizabeth Montgomery, and Venu Raman. "Abstract A77: RNA helicase DDX3 – A novel therapeutic target in sarcoma." In Abstracts: AACR Special Conference: Pediatric Cancer at the Crossroads: Translating Discovery into Improved Outcomes; November 3-6, 2013; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.pedcan-a77.
Повний текст джерелаHao, Liangliang, Justin Lo, and Sangeeta Bhatia. "Abstract 5088: Tumor penetrating RNA delivery for therapeutic benefit of pancreatic cancer." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-5088.
Повний текст джерелаPachera, E., A. Wunderlin, S. Assassi, G. Salazar, M. Frank-Bertoncelj, R. Dobrota, M. Brock, et al. "OP0086 Long noncoding RNA H19X as a new therapeutic target for fibrosis." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.4877.
Повний текст джерелаWoo, C., N. Clark, A. Sarode, N. Kaushal, K. Tran, T. Efthymiou, J. Abysalh, et al. "A Messenger RNA (mRNA)-Based Therapeutic Designed to Treat Primary Ciliary Dyskinesia." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1138.
Повний текст джерелаGoueli, Said A., and Kevin Hsiao. "Abstract 1162: Monitoring COVID-19 RNA methyltransferases activities for developing therapeutic drugs." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1162.
Повний текст джерелаGhazaly, Essam A., John Le Quesne, Dahai Jiang, Selanere L. Mangala, James Chettle, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, et al. "Abstract B30: The RNA-binding protein LARP1 is a cancer therapeutic target." In Abstracts: AACR Special Conference on Translational Control of Cancer: A New Frontier in Cancer Biology and Therapy; October 27-30, 2016; San Francisco, CA. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.transcontrol16-b30.
Повний текст джерелаMitra, Sheetal A., Anirban P. Mitra, Jonathan D. Buckley, William A. May, Philipp Kapranov, Robert J. Arceci, and Timothy J. Triche. "Abstract A43: Therapeutic importance of a long noncoding RNA in Ewing sarcoma." In Abstracts: AACR Special Conference: Pediatric Cancer at the Crossroads: Translating Discovery into Improved Outcomes; November 3-6, 2013; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.pedcan-a43.
Повний текст джерелаЗвіти організацій з теми "RNA therapeutic"
Chu, Jimmy, Kathryn Black, Luis Santos, and Steven Wall. The challenges of using RNA as a therapeutic or a gene-editing tool. Biophorum, November 2021. http://dx.doi.org/10.46220/2021cgt006.
Повний текст джерелаARIZONA STATE UNIV TEMPE CANCER RESEARCH INST. Discovery and Development of Therapeutic Drugs Against Lethal Human RNA Viruses: A Multidisciplinary Assault. Fort Belvoir, VA: Defense Technical Information Center, March 1992. http://dx.doi.org/10.21236/ada251561.
Повний текст джерелаPettit, George R. Discovery and Development of Therapeutic Drugs against Lethal Human RNA Viruses: a Multidisciplinary Assault. Fort Belvoir, VA: Defense Technical Information Center, July 1991. http://dx.doi.org/10.21236/ada239742.
Повний текст джерелаPettit, George R. Discovery and Development of Therapeutic Drugs against Lethal Human RNA- Viruses: A Multidisciplinary Assault. Fort Belvoir, VA: Defense Technical Information Center, February 1990. http://dx.doi.org/10.21236/ada219393.
Повний текст джерелаChen, Shuo. Anti-Androgen Receptor RNA Enzyme as a Novel Therapeutic Agent for Prostate Cancer In Vivo. Fort Belvoir, VA: Defense Technical Information Center, August 2006. http://dx.doi.org/10.21236/ada462865.
Повний текст джерелаChakraborty, Srijani. The Dawn of RNA Therapeutics. Spring Library, December 2020. http://dx.doi.org/10.47496/sl.blog.19.
Повний текст джерелаGiordano, Tony. Development of RNAi Libraries for Target Validation and Therapeutics. Fort Belvoir, VA: Defense Technical Information Center, March 2006. http://dx.doi.org/10.21236/ada452228.
Повний текст джерелаMao, Hai-Quan. Nanoparticle Delivery of RNAi Therapeutics for Ocular Vesicant Injury. Fort Belvoir, VA: Defense Technical Information Center, April 2014. http://dx.doi.org/10.21236/ada613316.
Повний текст джерелаMoore, Melissa. Phase II - Procurement of State of the Art Research Equipment to Support Faculty Members with the RNA Therapeutics Institute, a component of the Advanced Therapeutics Cluster at the University of Massachusetts Medical School. Office of Scientific and Technical Information (OSTI), October 2011. http://dx.doi.org/10.2172/1037882.
Повний текст джерелаChen, Xiaole, Peng Wang, Yunquan Luo, Yi-Yu Lu, Wenjun Zhou, Mengdie Yang, Jian Chen, Zhi-Qiang Meng, and Shi-Bing Su. Therapeutic Efficacy Evaluation and Underlying Mechanisms Prediction of Jianpi Liqi Decoction for Hepatocellular Carcinoma. Science Repository, September 2021. http://dx.doi.org/10.31487/j.jso.2021.02.04.sup.
Повний текст джерела