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Статті в журналах з теми "Regulation function"
Pandit, Abha, and Abhay Kumar Pandey. "Glycaemic regulation and metabolic syndrome: A reference to thyroid function state." Scholars Journal of Applied Medical Sciences 4, no. 6 (June 2016): 1906–8. http://dx.doi.org/10.21276/sjams.2016.4.6.7.
Повний текст джерелаNakamura, Ichiro, Naoyuki Takahashi, Eijiro Jimi, Nobuyuki Udagawa, and Tatsuo Suda. "Regulation of osteoclast function." Modern Rheumatology 22, no. 2 (April 2012): 167–77. http://dx.doi.org/10.3109/s10165-011-0530-8.
Повний текст джерелаLuo, T., and J. V. Garcia. "Regulation of Nef function." Research in Virology 148, no. 1 (January 1997): 64–68. http://dx.doi.org/10.1016/s0923-2516(97)81916-4.
Повний текст джерелаNoonan, Emily, Robert Place, Charles Giardina, and Lawrence Hightower. "Hsp70B' Regulation and Function." Cell Stress & Chaperones preprint, no. 2007 (2005): 1. http://dx.doi.org/10.1379/csc-278.
Повний текст джерелаNoonan, Emily J., Robert F. Place, Charles Giardina, and Lawrence E. Hightower. "Hsp70B′ regulation and function." Cell Stress & Chaperones 12, no. 3 (2007): 219. http://dx.doi.org/10.1379/csc-278.1.
Повний текст джерелаNoonan, Emily J., Robert F. Place, Charles Giardina, and Lawrence E. Hightower. "Hsp70B′ regulation and function." Cell Stress & Chaperones 12, no. 4 (2007): 393. http://dx.doi.org/10.1379/csc-278e.1.
Повний текст джерелаSuda, Tatsuo, Ichiro Nakamura, Eijiro Jimi, and Naoyuki Takahashi. "Regulation of Osteoclast Function." Journal of Bone and Mineral Research 12, no. 6 (June 1, 1997): 869–79. http://dx.doi.org/10.1359/jbmr.1997.12.6.869.
Повний текст джерелаZajac, J. D. "Regulation of parathyroid function." Bone 27, no. 4 (October 2000): 7. http://dx.doi.org/10.1016/s8756-3282(00)80017-4.
Повний текст джерелаMarcu, Kenneth B., Steven A. Bossone, and Amanda J. Patel. "myc Function and Regulation." Annual Review of Biochemistry 61, no. 1 (June 1992): 809–58. http://dx.doi.org/10.1146/annurev.bi.61.070192.004113.
Повний текст джерелаWoods, Douglas B., and Karen H. Vousden. "Regulation of p53 Function." Experimental Cell Research 264, no. 1 (March 2001): 56–66. http://dx.doi.org/10.1006/excr.2000.5141.
Повний текст джерелаДисертації з теми "Regulation function"
Hillier, Stephen Gilbert. "Regulation of ovarian function." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/26607.
Повний текст джерелаClay, L. "CDC20 function, regulation and proteolysis." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597750.
Повний текст джерелаBrandao, Haga Raquel. "Function and regulation of RhoBTB1." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/function-and-regulation-of-rhobtb1(0904ff24-d566-4987-8c61-440c09854eeb).html.
Повний текст джерелаBerry, David (David A. ). "Glycosaminoglycan regulation of cell function." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/34153.
Повний текст джерелаIncludes bibliographical references (p. 252-285).
Glycosaminoglycans (GAGs) are complex polysaccharides that exist both on the cell surface and free within the extracellular matrix. The intrinsic sequence variety stemming from the large number of building blocks that compose this biopolymer leads to substantial information density as well as to the ability to regulate a wide variety of important biological processes. With the recent and progressive emergence of biochemical and analytical tools to probe GAG structure and function, efforts can be taken to understand the role of GAGs in cell biology and in disease in the various physiological locations where GAGs can exist. As a first step to probe the functions of GAGs, the heparin/heparan sulfate-GAG (HSGAG)-fibroblast growth factor (FGF) system was examined. Understanding the role of HSGAGs in inducing FGF2 dimerization led to the development of a novel engineered protein that was found to be effective at promoting functional recovery in stroke. Subsequently, methods to isolate HSGAGs from the cell surface were optimized and the ability of HSGAGs to support FGF signaling was investigated. Cell surface HSGAGs can define the responsiveness of a given cell to FGF1 and FGF2 through multiple receptor isoforms. Stromal cell derived HSGAGs were also identified as critical regulators of tumor cell growth and metastasis, effecting not only FGF2., but also 1-integrin signaling.
(cont.) Other GAGs, including dermatan sulfates, were characterized as modulators of FGFs and vascular endothelial growth factors. Finally, FGFs and HSGAGs were found to have important roles in maintaining epithelial monolayer integrity, with syndecan-l serving as a critical factor in inflammatory bowel disease. In addition to understanding HSGAGs in their normal physiological settings, techniques to internalize them were developed. Poly(3-amino ester)s were found to condense heparin and enable its endocytosis into cells. Internalized heparin is preferentially taken up by cancer cells, which often have a faster endocytic rate than non-transformed cells, and promotes apoptotic cell death. Internalized heparin can also be used as a tool to probe cell function. In Burkitt's lymphoma, poly(3-amino ester)-heparin conjugates served to identify cell surface HSGAGs as an important modulator of cell growth that can be harnessed to inhibit growth. Finally, studies that sought to broaden the scope of GAG biology were undertaken. Cell surface HSGA(:is were identified as mediators of vascular permeability. Furthermore a novel technique to immobilize GAGs was employed. The interactions between GAG and substrate were via hydrogen bonding. Immobilization of GAGs alters their properties, such that they can affect cells in ways distinct from GAGs free in the ECM.
(cont.) Furthermore, immobilized GAGs can regulate cancer cell adhesion, growth and progression, and may offer a new way to regulate the activity of cancer cells. In addition to directly providing new potential therapeutics and drug targets, these studies represent a foundation to enable additional studies of GAG function. Future work harnessing the techniques presented may open new avenues of research and facilitate the development of novel GAG-based therapeutics.
by David Berry.
Ph.D.
Vespoli, Jessica L. "Genomic Regulation of Clock Function." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1449500602.
Повний текст джерелаTran, Stella Lê Minh. "Foxl2 regulation and function in gonadotropes." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116978.
Повний текст джерелаL'hormone folliculo-stimulante de l'hypophyse (FSH) est cruciale car elle régule gamétogenèse et fonction gonadique chez les mammifères. Une diminution dans la production de FSH peut mener à l'infertilité, mais les mécanismes contrôlant la synthèse de FSH demeurent incompris. Les activines de l'hypophyse stimulent la transcription du gène FSH sous-unité β (Fshb) dans les cellules gonadotropes; ceci est l'étape limitante dans la synthèse de l'hormone FSH. Les résults provenant de lignée gonadotrope immortalisée indiquent que la transcription de Fshb est stimulée par l'activine A; ceci est dépend des protéines homologues de Drosophila mothers against decapentaplegic (SMAD). Récemment, Forkhead box L2 (FOXL2) a été décrite comme étant un facteur-clé dans la stimulation de la transcription de Fshb induite par les SMADs et l'activine A. Ici, je dissèque les mécanismes expliquant la régulation et fonction de Foxl2 dans les cellules gonadotropes. Tout d'abord, la surexpression de FOXL2 et SMAD 2, 3, et 4 confère une réactivité à l'activine au promoteur du gène murin Fshb dans les cellules hétérologues. Sous stimulation par l'activine A, FOXL2 coopère de façon synergétique avec les SMADs pour activer le promoteur Fshb; cela nécessite que FOXL2 et SMAD3 (ou SMAD4) lient l'ADN. L'l'induction via SMAD3 du gène Fshb dépend de FOXL2 endogène dans les cellules homologues. Un élément proximal forkhead binding element (FBE) et un élément adjacent SMAD binding element (SBE) sont essentiels pour l'induction de l'activité du promoteur-reporter Fshb par FOXL2/SMAD3. Basé sur ces résultats, je propose un modèle où les activines stimulent la formation de complexes FOXL2-SMAD2/3/4 induisant la transcription du gène murinFshb via liaison à un élément SBE/FBE conservé du promoteur proximal. J'ai ensuite testé l'hypothèse que FOXL2 est nécessaire pour la synthèse de FSH in vivo en utilisant une approche Cre/lox: j'ai généré une souris knock-out conditionnelle (cKO) où Foxl2 est sélectivement absent dans les cellules gonadotropes. J'ai observé que les souris cKO sont hypogonadiques et souffrent d'une baisse de fertilité à l'âge adulte. J'ai démontré que la spermatogenèse et la folliculogénèse sont altérées chez les souris cKO. En effet, les cKO mâles ont un nombre diminué de spermatozoïdes, tandis que femelles cKO ovulent moins d'ovocytes pendant leur cycle oestral. J'ai démontré que cKO mâles et femelles sont déficientes en FSH, découlant d'une diminution d'ARN Fshb dans l'hypophyse. Les cultures primaires de cellules hypophysaires où Foxl2 est absent ne réagissent pas à l'activine A : Fshb est diminuée, tant au niveau basal que dans sa réponse au ligand. Ces résultats indiquent que l'expression de Foxl2 dans les gonadotropes est requise pour l'induction sélective de la production de FSH in vivo. Outre son rôle dans les gonadotropes, FOXL2 est également détecté dans les cellules thyrotropes de l'hypophyse, dans la paupière en développement et les cellules granuleuses de l'ovaire. Cependant les mécanismes qui régissent cette expression sélective n'ont pas encore été décrits. Afin d'étudier ce qui contrôle la transcription de Foxl2, j'ai cloné la région du promoteur murin de Foxl2. Ensuite, j'ai démontré une corrélation entre l'état de méthylation des CpGs du promoteur et l'expression des gènes, par lequel la méthylation exerce une inhibition sur le gène Foxl2 dans certaines cellules hétérologues. Mes résultats indiquent que Foxl2 n'est pas seulement contrôlé par la séquence de son promoteur et dévoilent un rôle possible pour la méthylation des CpGs dans la régulation de l'expression spécifique de Foxl2 chez la souris. En résumé, ma thèse définit un rôle nécessaire pour FOXL2 exprimé dans les gonadotropes pour la synthèse de Fshb et FSH, ainsi que la reproduction in vivo. Collectivement, mes recherches sur FOXL2 hypophysaire contribueront à identifier des causes de l'infertilité idiopathique ou encore trouver de nouvelles cibles pharmacologiques.
Cheng, C. W. "Regulation of endothelial and endometrial function." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597573.
Повний текст джерелаEnglish, Jane Louise. "Cellular regulation of matrix metalloproteinase function." Thesis, University of East Anglia, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247107.
Повний текст джерелаRaghavan, Srikala. "Connectin function and regulation in Drosophila." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624670.
Повний текст джерелаBERCLAZ, PIERRE-YVES. "REGULATION OF ALVEOLAR MACROPHAGE IMMUNE FUNCTION." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1022869185.
Повний текст джерелаКниги з теми "Regulation function"
C, Froehner Stanley, and Bennett Vann, eds. Cytoskeletal regulation of membrane function. New York: Rockefeller University Press, 1997.
Знайти повний текст джерелаMaki, Nina Diana. LUCA-15 function and regulation. Sudbury, Ont: Laurentian University, School of Graduate Studies, 2004.
Знайти повний текст джерелаMeans, Anthony R. Calcium regulation of cellular function. New York: Raven Press, 1995.
Знайти повний текст джерелаname, No. Neurotransmitter transporters: Structure, function, and regulation. 2nd ed. Totowa, NJ: Humana Press, 2002.
Знайти повний текст джерелаWolffe, A. Regulation of chromatin structure and function. Austin, TX: R.G. Landes, 1994.
Знайти повний текст джерелаDeutsch, Andreas, Jonathon Howard, Martin Falcke, and Walter Zimmermann, eds. Function and Regulation of Cellular Systems. Basel: Birkhäuser Basel, 2004. http://dx.doi.org/10.1007/978-3-0348-7895-1.
Повний текст джерелаBevan, John A., Gabor Kaley, and Gabor M. Rubanyi, eds. Flow-Dependent Regulation of Vascular Function. New York, NY: Springer New York, 1995. http://dx.doi.org/10.1007/978-1-4614-7527-9.
Повний текст джерелаMahesh, Virendra B., Dharam S. Dhindsa, Everett Anderson, and Satya P. Kalra, eds. Regulation of Ovarian and Testicular Function. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5395-9.
Повний текст джерелаDeutsch, Andreas. Function and Regulation of Cellular Systems. Basel: Birkhäuser Basel, 2004.
Знайти повний текст джерелаNaik, Salma Iqbal. Physiological regulation of gonadotroph function in mice. Birmingham: University of Birmingham, 1985.
Знайти повний текст джерелаЧастини книг з теми "Regulation function"
Chen, Xi, Wai-Ki Ching, and Nam-Kiu Tsing. "Regulation Function." In Encyclopedia of Systems Biology, 1833–34. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_378.
Повний текст джерелаBonavida, Ben, and Elizabeth Simpson. "Function of Effector T Cells." In Immune Regulation, 363–67. Totowa, NJ: Humana Press, 1985. http://dx.doi.org/10.1007/978-1-4612-4996-2_43.
Повний текст джерелаSugino, Norihiro, Isao Tamura, Ryo Maekawa, and Kosuke Jozaki. "Decidualization and Epigenetic Regulation." In Uterine Endometrial Function, 125–37. Tokyo: Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-55972-6_8.
Повний текст джерелаMcNaughton, L., A. Radomski, G. Sawicki, and Marek W. Radomski. "Regulation of Platelet Function." In Nitric Oxide, 235–57. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-57077-3_11.
Повний текст джерелаOkada, Hidetaka, Tomoko Tsuzuki, Hiromi Murata, Atsushi Kasamatsu, Tomoo Yoshimura, and Hideharu Kanzaki. "Regulation of Angiogenesis in the Human Endometrium." In Uterine Endometrial Function, 83–103. Tokyo: Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-55972-6_6.
Повний текст джерелаCerottini, J. C., H. R. MacDonald, J. Lowenthal, and R. Shimonkevitz. "Non Antigen-Specific Surface Molecules Involved in T Lymphocyte Function." In Immune Regulation, 27–38. Totowa, NJ: Humana Press, 1985. http://dx.doi.org/10.1007/978-1-4612-4996-2_3.
Повний текст джерелаRiedl, Stefan J., and Fiona L. Scott. "Caspases: Activation, Regulation, and Function." In Essentials of Apoptosis, 3–24. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-381-7_1.
Повний текст джерелаvan Wimersma Greidanus, T. B., and A. B. Grossman. "Opioid Regulation of Pituitary Function." In Progress in Sensory Physiology, 1–64. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-75964-2_1.
Повний текст джерелаKirchheim, H. R. "Baroreceptor Regulation of Renal Function." In Baroreceptor Reflexes, 181–208. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76366-3_7.
Повний текст джерелаBaslé, Arnaud, and Anne H. Delcour. "Regulation of Bacterial Porin Function." In Bacterial and Eukaryotic Porins, 79–98. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527603875.ch5.
Повний текст джерелаТези доповідей конференцій з теми "Regulation function"
Karkanaki, Artemis. "SYSTEMIC REGULATION OF PHYSIOLOGICAL FUNCTION AND REPRODUCTIVE MEDICINE: CURRENT PROBLEMS." In MODERN PROBLEMS IN SYSTEMIC REGULATION OF PHYSIOLOGICAL FUNCTIONS. NPG Publishing, 2019. http://dx.doi.org/10.24108/5-2019-confnf-2.
Повний текст джерелаShukurova, P., Kh Babayev, S. Gasanova, and G. Gasimova. "EXPERIMENTAL EVALUATION OF THE SAFFRON (CROCUS SATIVUS L. İRIDACEAE) ON THE ANIMALS REPRODUCTIVE FUNCTION." In MODERN PROBLEMS IN SYSTEMIC REGULATION OF PHYSIOLOGICAL FUNCTIONS. NPG Publishing, 2019. http://dx.doi.org/10.24108/5-2019-confnf-84.
Повний текст джерелаZhu, Yuncheng, and Okita Hideki. "Traffic management using value function-based regulation." In 2017 19th Asia-Pacific Network Operations and Management Symposium (APNOMS). IEEE, 2017. http://dx.doi.org/10.1109/apnoms.2017.8094197.
Повний текст джерелаSokol, Nicholas. "Regulation and function oflet-7-ComplexmicroRNAs inDrosophila melanogaster." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.82459.
Повний текст джерелаMuslim, Shohib, Hudriyah Mundzir, and Ane Fany Novitasari. "Regulation on Independent Function of Financial Services Authority." In 1st Annual Management, Business and Economic Conference (AMBEC 2019). Paris, France: Atlantis Press, 2020. http://dx.doi.org/10.2991/aebmr.k.200415.009.
Повний текст джерелаKumar, Vineet. "On the regulation and transfer function of photon." In ADVANCES IN BASIC SCIENCE (ICABS 2019). AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5122367.
Повний текст джерелаWan, Qingfeng, and Wenbin Zhang. "Study of Cellular Immune Function and Regulation Measurement." In 2016 6th International Conference on Machinery, Materials, Environment, Biotechnology and Computer. Paris, France: Atlantis Press, 2016. http://dx.doi.org/10.2991/mmebc-16.2016.450.
Повний текст джерелаYang, Yizeng, Taicheng Zhou, Zhen Zong, Gwen Lomberk, Raul Urrutia, and Jonathan Katz. "Abstract 2087: Regulation of p53 function by KLF5." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2087.
Повний текст джерела"Update status of mouse resources for studies of gene function and disease at RIKEN BRC." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-248.
Повний текст джерелаVelontrasina, Irène, Denis Payet, and Rémy Courdier. "Regulation Function for Agent Adaptation Issues in Ambient Environment." In the 11th International Conference. New York, New York, USA: ACM Press, 2019. http://dx.doi.org/10.1145/3307363.3307376.
Повний текст джерелаЗвіти організацій з теми "Regulation function"
Treistman, Steven N. Regulation of Voltage-Dependent Channel Function. Fort Belvoir, VA: Defense Technical Information Center, August 1988. http://dx.doi.org/10.21236/ada200375.
Повний текст джерелаMeidan, Rina, and Robert Milvae. Regulation of Bovine Corpus Luteum Function. United States Department of Agriculture, March 1995. http://dx.doi.org/10.32747/1995.7604935.bard.
Повний текст джерелаTublitz, Nathan. Neural Regulation Of Chromatophore Function In Cephalopods. Fort Belvoir, VA: Defense Technical Information Center, May 2015. http://dx.doi.org/10.21236/ada619935.
Повний текст джерелаLers, Amnon, and Pamela J. Green. LX Senescence-Induced Ribonuclease in Tomato: Function and Regulation. United States Department of Agriculture, September 2003. http://dx.doi.org/10.32747/2003.7586455.bard.
Повний текст джерелаStarczynowski, Daniel. Regulation and Function of TIFAB in Myelodysplastic Syndrome. Fort Belvoir, VA: Defense Technical Information Center, August 2014. http://dx.doi.org/10.21236/ada613223.
Повний текст джерелаKotwaliwale, Chitra, and Sue Biggins. Regulation and Function of the Ipl1/Aurora Kinase. Fort Belvoir, VA: Defense Technical Information Center, May 2004. http://dx.doi.org/10.21236/ada432454.
Повний текст джерелаStarczynowski, Daniel. Regulation and Function of TIFAB in Myelodysplastic Syndrome. Fort Belvoir, VA: Defense Technical Information Center, June 2012. http://dx.doi.org/10.21236/ada567467.
Повний текст джерелаStarczynowski, Daniel. Regulation and Function of TIFAB in Myelodysplastic Syndrome. Fort Belvoir, VA: Defense Technical Information Center, June 2013. http://dx.doi.org/10.21236/ada585851.
Повний текст джерелаBalk, Steven P. Regulation of AR Degradation and Function by Ubiquitylation. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada615205.
Повний текст джерелаDoi, Roy H. Structure, Function and Regulation of the Clostridium cellulovorans Cellulosome. Office of Scientific and Technical Information (OSTI), June 2008. http://dx.doi.org/10.2172/951625.
Повний текст джерела