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Добірка наукової літератури з теми "PTBD"

Автор: Grafiati

Опубліковано: 11 березня 2023

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Статті в журналах з теми "PTBD"

Nennstiel, Simon, Matthias Treiber, Alexander Faber, Bernhard Haller, Stefan von Delius, Roland M. Schmid, and Bruno Neu. "Comparison of Ultrasound and Fluoroscopically Guided Percutaneous Transhepatic Biliary Drainage." Digestive Diseases 37, no. 1 (September 25, 2018): 77–86. http://dx.doi.org/10.1159/000493120.

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Background: Percutaneous transhepatic biliary drainage (PTBD) plays a significant role especially in the palliation of an endoscopically inaccessible biliary system. Since a standard technique of PTBD is not defined, we compared a fluoroscopically guided technique (F-PTBD) with an ultrasound (US-PTBD) guided approach. Patients and Methods: Procedure characteristics, success-rates and complication-rates of the different PTBD techniques were compared in patients who underwent PTBD between October 1, 2006, and December 31, 2014. Results: In 195 patients, 251 PTBDs (207 F-PTBDs, 44 US-PTBDs) were performed. F-PTBDs were mostly inserted from the right and US-PTBDs from the left. Patient age, gender and physical status were comparable in both techniques. There was no difference regarding overall procedure success (90%/86.4%), overall interventional complication rates (10.6%/9.1%), fluoroscopy times, intervention times or sedatives dosages. However, major complications were only encountered in F-PTBDs. There was a higher success rate for F-PTBD vs. US-PTBD from the right side (91.9 vs. 75%; p = 0.033) and a trend towards a higher success rate for US guidance from the left side (82.9 vs. 95.8%; p = 0.223). Conclusions: For drainage of the right biliary system F-PTBD seems superior over the US-PTBD technique used in this study. However, major complications can occur more frequently in F-PTBD.

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Paik, Woo, Nah Lee, Yousuke Nakai, Hiroyuki Isayama, Dongwook Oh, Tae Song, Sang Lee, et al. "Conversion of external percutaneous transhepatic biliary drainage to endoscopic ultrasound-guided hepaticogastrostomy after failed standard internal stenting for malignant biliary obstruction." Endoscopy 49, no. 06 (February 14, 2017): 544–48. http://dx.doi.org/10.1055/s-0043-102388.

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Abstract Background and study aim Percutaneous transhepatic biliary drainage (PTBD) is a rescue procedure after a failed endoscopic retrograde cholangiopancreatography. As PTBD causes patient discomfort, conversion of the PTBD to internal biliary stenting (PTBDS) may be required; however, PTBDS is sometimes difficult because of the tight stricture. We evaluated the efficacy and safety of conversion of external PTBD to endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) after failed PTBDS. Patients and methods A total of 16 patients with malignant distal biliary obstruction who underwent conversion of external PTBD to EUS-HGS after failed PTBDS were enrolled from two institutions in Korea and Japan. Data were analyzed retrospectively. Results The technical and clinical success rates were 100 % and 81 %, respectively. Early adverse events developed in two patients: proximal stent migration (n = 1), and cholecystitis (n = 1). Stents were occluded or migrated distally in five patients. The mean duration of stent patency was 402 days. Conclusions Conversion of external PTBD to EUS-HGS may be a good rescue option after failed PTBDS.

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Schmitz, Daniel, Niels Weller, Matthias Doll, Simon Weingärtner, Nuria Pelaez, Gabriele Reinmuth, Svetlana Hetjens, and Jochen Rudi. "An Improved Method of Percutaneous Transhepatic Biliary Drainage Combining Ultrasound-Guided Bile Duct Puncture with Metal Stent Implantation by Fluoroscopic Guidance and Endoscopic Visualization as a One-Step Procedure: A Retrospective Cohort Study." Journal of Clinical Interventional Radiology ISVIR 02, no. 03 (November 27, 2018): 135–43. http://dx.doi.org/10.1055/s-0038-1675883.

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Abstract Aims In recently published comparative studies, it is reported that percutaneous transhepatic biliary drainage (PTBD) is less successful, causes more adverse events, and needs more re-interventions than endoscopic ultrasound-guided biliary drainage (EUS-BD) in patients with malignant extrahepatic bile duct obstruction when endoscopic retrograde cholangiopancreatography (ERCP) fails. Could an improved technique of PTBD produce better results to use this technique for further comparative studies with EUSBD? Methods In our tertiary referral hospital, 116 prospectively documented, and retrospectively analyzed PTBDs with ultrasound guided ductal puncture were performed. In 16 of 30 PTBDs with metal stent implantation in malignant diseases, metal stent was inserted as a one-step procedure by endoscopic luminal guidance in the first session. Results Fifteen of 16 (94%) or 14/16 (88%) of PTBDs with primary metal stent implantation were technically or clinically successful. Mainly the left liver was used as access route for PTBD. Procedure time was 68.1 minutes (25–118), fluoroscopic time: 18.6 minutes (3–46), and patient radiation exposure: 5957 μGy/m2 (471–17,569). In 2/16 (12.5%) patients, adverse events (1 × mild and 1 × moderate grade of severity) were documented. One re-intervention was necessary (0.1/patient) in the observation time of 6 months. The mean overall survival time was 163.2 (7–864) days after PTBD. Conclusions PTBD with ultrasound-guided ductal puncture and primary metal implantation by endoscopic luminal guidance in patients with malignant extrahepatic bile duct obstruction showed good technical and clinical success and low adverse event and reintervention rates in our retrospective cohort study. Clinical Trial Registration: ClinicalTrials.gov ID: NCT03541590.

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Rees, James, Jemma Mytton, Felicity Evison, Kamarjit Singh Mangat, Prashant Patel, and Nigel Trudgill. "The outcomes of biliary drainage by percutaneous transhepatic cholangiography for the palliation of malignant biliary obstruction in England between 2001 and 2014: a retrospective cohort study." BMJ Open 10, no. 1 (January 2020): e033576. http://dx.doi.org/10.1136/bmjopen-2019-033576.

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IntroductionRelieving obstructive jaundice in inoperable pancreato-biliary cancers improves quality of life and permits chemotherapy. Percutaneous transhepatic cholangiography with drainage and/or stenting relieves jaundice but can be associated with significant morbidity and mortality. Percutaneous transhepatic biliary drainage (PTBD) in malignant biliary obstruction was therefore examined in a national cohort to establish risk factors for poor outcomes.MethodsRetrospective study of adult patients undergoing PTBD for palliation of pancreato-biliary cancer in England between 2001 and 2014 identified from Hospital Episode Statistics. Multivariate logistic regression analysis was used to examine associations with mortality and the need for a repeat PTBD within 2 months.Results16 822 patients analysed (median age 72 (range 19–104) years, 50.3% men). 58% pancreatic and 30% biliary tract cancer. In-hospital and 30-day mortality were 15.3% (95% CI 14.7% to 15.9%) and 23.1% (22.4%–23.8%), respectively. 20.2% suffered a coded complication within 3 months. Factors associated with 30-day mortality: age (≥81 years OR 2.68 (95% CI 2.37 to 3.03), p<0.001), increasing comorbidity (Charlson score 20+, 3.10 (2.64–3.65), p<0.001), pre-existing renal dysfunction (2.37 (2.12–2.65), p<0.001) and non-pancreatic cancer (unspecified biliary tract 1.28 (1.08–1.52), p=0.004). Women had lower mortality (0.91 (0.84–0.98), p=0.011), as did patients undergoing PTBD in a ‘higher volume’ provider (84–180 PTBDs per year 0.68 (0.58–0.79), p<0.001).ConclusionsIn patients undergoing PTBD for the palliation of malignant biliary obstruction, 30-day mortality was high at 23.1%. Mortality was higher in older patients, men, those with increasing comorbidity, a cancer site other than pancreas and at ‘lower-volume’ PTBD providers.

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Kim, Ki-Han, Ho-Byoung Lee, Sung-Heun Kim, Min-Chan Kim, and Ghap-Joong Jung. "Role of Percutaneous Transhepatic Biliary Drainage in Patients With Complications After Gastrectomy." International Surgery 101, no. 1-2 (January 1, 2016): 78–83. http://dx.doi.org/10.9738/intsurg-d-15-00117.1.

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The aim of this study was to elucidate the role of percutaneous transhepatic biliary drainage (PTBD) in patients with duodenal stump leakage (DSL) and afference loop syndrome (ALS) postgastrectomy for malignancy or benign ulcer perforation. Percutaneous transhepatic biliary drainage (PTBD) is an interventional radiologic procedure used to promote bile drainage. Duodenal stump leakage (DSL) and afferent loop syndrome (ALS) can be serious complications after gastrectomy. From January 2002 through December 2014, we retrospectively reviewed 19 patients who underwent PTBD secondary to DSL and ALS postgastrectomy. In this study, a PTBD tube was placed in the proximal duodenum near the stump or distal duodenum in order to decompress and drain bile and pancreatic fluids. Nine patients with DSL and 10 patients with ALS underwent PTBD. The mean hospital stay was 34.3 days (range, 12 to 71) in DSL group and 16.4 days (range, 6 to 48) in ALS group after PTBD. A liquid or soft diet was started within 2.6 days (range, 1 to 7) in the ALS group and within 3.4 days (range, 0 to 15) in the DSL group after PTBD. One patient with DSL had PTBD changed, and 2 patients with ALS underwent additional surgical interventions after PTBD. The PTBD procedure, during which the tube was inserted into the duodenum, was well-suited for decompression of the duodenum as well as for drainage of bile and pancreatic fluids. This procedure can be an alternative treatment for cases of DSL and ALS postgastrectomy.

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Angulo, Jenniffer, Carlos Joaquín Cáceres, Nataly Contreras, Leandro Fernández-García, Nathalie Chamond, Melissa Ameur, Bruno Sargueil, and Marcelo López-Lastra. "Polypyrimidine-Tract-Binding Protein Isoforms Differentially Regulate the Hepatitis C Virus Internal Ribosome Entry Site." Viruses 15, no. 1 (December 20, 2022): 8. http://dx.doi.org/10.3390/v15010008.

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Translation initiation of the hepatitis C virus (HCV) mRNA depends on an internal ribosome entry site (IRES) that encompasses most of the 5′UTR and includes nucleotides of the core coding region. This study shows that the polypyrimidine-tract-binding protein (PTB), an RNA-binding protein with four RNA recognition motifs (RRMs), binds to the HCV 5′UTR, stimulating its IRES activity. There are three isoforms of PTB: PTB1, PTB2, and PTB4. Our results show that PTB1 and PTB4, but not PTB2, stimulate HCV IRES activity in HuH-7 and HEK293T cells. In HuH-7 cells, PTB1 promotes HCV IRES-mediated initiation more strongly than PTB4. Mutations in PTB1, PTB4, RRM1/RRM2, or RRM3/RRM4, which disrupt the RRM’s ability to bind RNA, abrogated the protein’s capacity to stimulate HCV IRES activity in HuH-7 cells. In HEK293T cells, PTB1 and PTB4 stimulate HCV IRES activity to similar levels. In HEK293T cells, mutations in RRM1/RRM2 did not impact PTB1′s ability to promote HCV IRES activity; and mutations in PTB1 RRM3/RRM4 domains reduced, but did not abolish, the protein’s capacity to stimulate HCV IRES activity. In HEK293T cells, mutations in PTB4 RRM1/RRM2 abrogated the protein’s ability to promote HCV IRES activity, and mutations in RRM3/RRM4 have no impact on PTB4 ability to enhance HCV IRES activity. Therefore, PTB1 and PTB4 differentially stimulate the IRES activity in a cell type-specific manner. We conclude that PTB1 and PTB4, but not PTB2, act as IRES transacting factors of the HCV IRES.

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Kim, Min Uk, Yoontaek Lee, Jae Hwan Lee, Soo Buem Cho, Myoung Seok Lee, Young Ho So, and Young Ho Choi. "Predictive factors affecting percutaneous drainage duration in the percutaneous treatment of common bile duct stones." PLOS ONE 16, no. 3 (March 2, 2021): e0248003. http://dx.doi.org/10.1371/journal.pone.0248003.

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The duration of percutaneous transhepatic biliary drainage (PTBD) is a critical factor that determines the duration of treatment. This study aimed to evaluate factors affecting the PTBD duration in patients who underwent percutaneous treatment of common bile duct (CBD) stones. This study analyzed data of 169 patients who underwent percutaneous treatment of CBD stones from June 2009 to June 2019. Demographic data, characteristics of stone, procedure-related factors, and laboratory findings before the insertion of PTBD tubes were retrospectively evaluated. To assess the effect of confounding factors on the PTBD duration, multivariate linear regression analysis was applied, incorporating significant predictive factors identified in the univariate regression analysis. In the univariate regression analysis, the predictive factor that showed high correlation with the PTBD duration was the initial total bilirubin level (coefficient = 0.68, P < .001) followed by the short diameter of the largest stone (coefficient = 0.19, P = .056), and previous endoscopic sphincterotomy (coefficient = -2.50, P = .086). The multivariate linear regression analysis showed that the initial total bilirubin level (coefficient = 0.50, P < .001) and short diameter of the largest stone (coefficient = 0.16, P = .025) were significantly related to the PTBD duration. The total bilirubin level before PTBD tube insertion and the short diameter of the largest CBD stone were predictive factors for the PTBD duration in patients who underwent percutaneous CBD stone removal. Careful assessment of these factors might help in predicting the treatment period, thereby improving the quality of patient care.

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Lesmana, C. Rinaldi A., Rino A. Gani, Irsan Hasan, Andri Sanityoso Sulaiman, Khek Yu Ho, Vinay Dhir, and Laurentius A. Lesmana. "Palliative Endoscopic Ultrasound Biliary Drainage for Advanced Malignant Biliary Obstruction: Should It Replace the Percutaneous Approach?" Case Reports in Gastroenterology 13, no. 3 (September 25, 2019): 385–97. http://dx.doi.org/10.1159/000502835.

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Endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic biliary drainage (PTBD) are the standard of care in malignant biliary obstruction cases. Recently, endoscopic ultrasound-guided biliary drainage (EUS-BD) has been widely used after unsuccessful ERCP. However, the patient’s clinical impact of EUS-BD over PTBD is still not obvious. Therefore, this case series study aims to evaluate the clinical outcomes of patients with advanced malignant biliary obstruction who underwent EUS-BD after failed ERCP. A retrospective database study was performed between January 2016 and June 2018 in patients with advanced malignant biliary obstruction. Patients were consecutively enrolled without randomization. Treatment options consisted of ERCP and PTBD or EUS-BD if ERCP failed. Based on 144 biliary obstruction cases, 38 patients were enrolled; 24 (63.2%) were men. The patients’ mean age was 66.8 ± 12.36 years. The most common cause of malignant biliary obstruction was pancreatic cancer (44.7%). Biliary drainage was achieved by ERCP (39.5%), PTBD (39.5%), and EUS-BD (21.1%). The technical success rate was 86.7% by PTBD and 87.5% by EUS-BD (p = 1.000), while the clinical success rate was 93.3% by PTBD and 62.5% by EUS-BD (p = 0.500). The median survival in patients who underwent PTBD versus those wo underwent EUS-BD was 11 versus 3 months (log-rank p = 0.455). In conclusion, there is no significant advantage of EUS-BD when compared to PTBD in terms of clinical success and survival benefit in advanced malignant biliary obstruction.

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Back, Sung Hoon, Yoon Ki Kim, Woo Jae Kim, Sungchan Cho, Hoe Rang Oh, Jung-Eun Kim, and Sung Key Jang. "Translation of Polioviral mRNA Is Inhibited by Cleavage of Polypyrimidine Tract-Binding Proteins Executed by Polioviral 3Cpro." Journal of Virology 76, no. 5 (March 1, 2002): 2529–42. http://dx.doi.org/10.1128/jvi.76.5.2529-2542.2002.

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ABSTRACT The translation of polioviral mRNA occurs through an internal ribosomal entry site (IRES). Several RNA-binding proteins, such as polypyrimidine tract-binding protein (PTB) and poly(rC)-binding protein (PCBP), are required for the poliovirus IRES-dependent translation. Here we report that a poliovirus protein, 3Cpro (and/or 3CDpro), cleaves PTB isoforms (PTB1, PTB2, and PTB4). Three 3Cpro target sites (one major target site and two minor target sites) exist in PTBs. PTB fragments generated by poliovirus infection are redistributed to the cytoplasm from the nucleus, where most of the intact PTBs are localized. Moreover, these PTB fragments inhibit polioviral IRES-dependent translation in a cell-based assay system. We speculate that the proteolytic cleavage of PTBs may contribute to the molecular switching from translation to replication of polioviral RNA.

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Sportes, Adrien, Marine Camus, Michel Greget, Sarah Leblanc, Romain Coriat, Jürgen Hochberger, Stanislas Chaussade, Sophie Grabar, and Frédéric Prat. "Endoscopic ultrasound-guided hepaticogastrostomy versus percutaneous transhepatic drainage for malignant biliary obstruction after failed endoscopic retrograde cholangiopancreatography: a retrospective expertise-based study from two centers." Therapeutic Advances in Gastroenterology 10, no. 6 (April 10, 2017): 483–93. http://dx.doi.org/10.1177/1756283x17702096.

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Background: Percutaneous transhepatic biliary drainage (PTBD) is widely performed as a salvage procedure in patients with unresectable malignant obstruction of the common bile duct (CBD) after failed endoscopic retrograde cholangiopancreatography (ERCP) or in case of surgically altered anatomy. Endoscopic ultrasound-guided hepaticogastrostomy (EU-HGS) is a more recently introduced alternative to relieve malignant obstructive jaundice. The aim of this prospective observational study was to compare the outcome, efficacy and adverse events of EU-HGS and PTBD. Methods: From April 2012 to August 2015, consecutive patients with malignant CBD obstruction who underwent EU-HGS or PTBD in two tertiary-care referral centers were included. The primary endpoint was the clinical success rate. Secondary endpoints were technical success, overall survival, procedure-related adverse events, incidence of adverse events, and reintervention rate. Results: A total of 51 patients (EU-HGS, n = 31; PTBD, n = 20) were included. Median survival was 71 days (range 25–75th percentile; 30–95) for the EU-HGS group and 78 days (range 25–75th percentile; 42–108) for the PTBD group ( p = 0.99). Technical success was achieved in all patients in both groups. Clinical success was achieved in 25 (86%) of 31 patients in the EU-HGS group and in 15 (83%) of 20 patients in the PTBD group ( p = 0.88). There was no difference in adverse events rates between the two groups (EU-HGS: 16%; PTBD: 10%) ( p = 0.69). Four deaths within 1 month (two hemorrhagic and two septic) were considered procedure related (two in the EU-HGS group and two in the PTBD group). Overall reintervention rate was significantly lower after EU-HGS ( n = 2) than after PTBD ( n = 21) ( p = 0.0001). Length of hospital stay was shorter after EU-HGS (8 days versus 15 days; p = 0.002). Conclusions: EU-HGS can be an effective and safe mini invasive-procedure alternative to PTBD, with similar success and adverse-event rates, but with lower rates of reintervention and length of hospitalization.

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Більше джерел

Дисертації з теми "PTBD"

Henkel, Nele. "Die Bedeutung traumatischer Erfahrungen und der Posttraumatischen Belastungsstörung für die Lebensqualität in der älteren Bevölkerung Deutschlands." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-205970.

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Hintergrund: Der Zweite Weltkrieg und die damit verbundenen traumatischen Ereignisse können auch Jahrzehnte später bei der ehemaligen Kriegsgeneration Deutschlands mit langfristigen und schwerwiegenden gesundheitlichen Folgen einhergehen. Insbesondere die Erforschung von Langzeitverläufen traumatisierender Erlebnisse befindet sich noch in ihren Anfängen. Ziele: Es werden die Auswirkungen traumatischer Erfahrungen und posttraumatischer Belas-tungssymptomatik auf die heutige gesundheitsbezogene Lebensqualität der älteren Bevölkerung Deutschlands (bis 1948 geboren) untersucht. Die Zusammenhänge werden unter dem Einfluss komorbider Depressivität, somatischer Symptome und körperlicher Erkrankungen analysiert. Material und Methoden: Diese Arbeit untersucht die physische und psychische gesund-heitsbezogene Lebensqualität (SF12v2-Fragebogen zur gesundheitsbezogenen Lebensqua-lität), traumatische Erfahrungen (Traumaliste des M-CIDI), Posttraumatische Belastungsstörung (PTBS) entsprechend des DSM-IV, partielle PTBS (Posttraumatic Diagnostic Scale, PDS), körperliche Erkrankungen (Multimorbiditätsfragebogen), Depressions- und Somatisierungssymptomatik (Patient Health Questionnaire, PHQ-D) in einer repräsentativen Stichprobe der 60-85 jährigen Bevölkerung Deutschlands (N = 1659) mit Hilfe von Selbstbeurteilungsverfahren. Ergebnisse: Personen mit traumatischen Erfahrungen in der Lebensgeschichte berichten eine niedrigere Lebensqualität als Personen ohne traumatische Erfahrungen. Zudem findet sich mit steigender Anzahl der traumatischen Erfahrungen eine niedrigere physische und psychische Lebensqualität. Auch haben Personen mit einer Vollbild- oder partiellen PTBS eine niedrigere körperliche und psychische gesundheitsbezogene Lebensqualität. Beeinträchtigungen in der physischen gesundheitsbezogenen Lebensqualität werden hauptsächlich durch komorbide depressive und somatische Symptome und körperliche Erkrankungen erklärt. Auf die Beeinträchtigungen der psychischen gesundheitsbezogenen Lebensqualität haben sowohl traumatische Erfahrungen und posttraumatische Belastungssymptomatik als auch komorbide Depressions- und Somatisierungssymptomatik Einfluss. Die PTBS führt sowohl bei kategorialer als auch bei dimensionaler Betrachtung zur Beeinträchtigung der gesundheitsbezogenen Lebensqualität; stärkster Einfluss wird auf die psychische Dimension genommen. Schlussfolgerung: Selbst nach Jahrzehnten können potentiell traumatisierende Erlebnisse in der Folge mit erheblichen körperlichen und psychosozialen Beeinträchtigungen einhergehen. Im Umgang mit Älteren sollten neu auftretende oder zunehmende gesundheitliche Beschwerden immer vor dem Hintergrund der historisch-biographischen Perspektive betrachtet werden. Dabei sollte auch subsyndromalen Störungsbildern genügend Beachtung zukommen. Dem Einsatz von Messinstrumenten zur Erfassung der Lebensqualität in der Diagnostik und zur Verlaufsbeurteilung sollte mehr Bedeutung beigemessen werden.

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Watson, Sian. "PTSD and violence." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4056/.

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This thesis aims to explore the role of trauma in an individual’s pathway to violence. Professionals consider offenders’ history of trauma when assessing risk of violence, and research has found an established relationship between Post-Traumatic Stress Disorder (PTSD) and perpetration of violence. Military populations may be particularly vulnerable to this relationship. The introduction explores relevant theories. The second chapter presents a systematic review of literature relating to the relationship between PTSD and violence in military populations. Few mediating psychological processes have been identified, therefore the role of cognition is considered. Chapter Three examines the psychometric properties of a measure of violent thoughts – the Firestone Assessment of Violent Thoughts (FAVT). This measure is used alongside the Schedule of Imagined Violence (SIV) in a research study in Chapter Four which aims to empirically assess the role of violent cognitions in mediating the relationship between PTSD and violence in a military population. The results support the relationship between PTSD and violence, PTSD and violent cognitions, and violent cognitions and violent behaviour. Violent fantasy measured by the SIV mediated this relationship. However, the violent thoughts measured by the FAVT did not account for a sufficient amount of the variance, suggesting there are other mediating factors. These findings are discussed in the final chapter contextualised in the literature and the implications for practice. Finally, it is considered whether a unique pathway to violence exists for military populations with PTSD, and a model of this pathway is presented based on the findings of this thesis.

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Fagelson, Marc A. "Tinnitus and PTSD." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/1668.

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Miller, Susannah. "The Relation of Witnessing Interparental Violence to PTSD and Complex PTSD." Thesis, University of North Texas, 2011. https://digital.library.unt.edu/ark:/67531/metadc68018/.

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Complex posttraumatic stress disorder (CPTSD) integrates symptoms common to victims of "complex" traumas, like childhood physical or sexual abuse, with the diagnostic criteria of posttraumatic stress disorder (PTSD). It was hypothesized that a history of witnessing interparental violence would be related to adulthood CPTSD symptoms. Results from hierarchical multiple regressions with 287 college students showed that witnessing interparental violence and experiencing child physical abuse predicted higher levels of CPTSD, PTSD, and depression symptoms. After controlling for child abuse, witnessing interparental violence predicted higher levels of traditional PTSD symptoms, but it did not predict an increase in overall CPTSD symptom severity or depression. Results suggest that the traditional PTSD construct, rather than CPTSD, best accounts for the symptoms of those who witnessed interparental violence in childhood.

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Eklöf, Maria. "Bildterapi med PTSD-patienter." Thesis, Ersta Sköndal högskola, S:t Lukas utbildningsinstitut, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-3985.

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Syftet med studien var att synliggöra hur bildterapeuter arbetar med vuxna med PTSD, och eventuella skillnader och likheter i arbetssätt. Ett annat syfte var att få ökad kunskap om hur bildterapi bedrivs vid PTSD och vilka delar i behandlingen bildterapeuterna ser som verksamma. Frågeställningarna var: a) Arbetar bildterapeuter annorlunda vid PTSD än vid annan problematik? b)Vilka beståndsdelar i det bildterapeutiska arbetet ser bildterapeuten som särskilt verksamma vid PTSD? Metod för studien var semistrukturerade intervjuer med 6 bildterapeuter med erfarenhet av att arbeta med PTSD. Fem intervjuer gjordes via personliga möten och en via Skype. Intervjuerna spelades in digitalt, transkriberades och bearbetades därefter genom Tematisk Analys. Resultaten visar att bildterapeuterna håller fast vid sin terapeutiska metod oavsett problematik hos patienten de möter men att förhållningssättet förändras när diagnosen PTSD finns från terapistart. Vid bildterapi med PTSD-patienter ser bildterapeuterna flera avgörande faktorer, där bl.a. den skapade bilden utgör en viktig del, liksom att kreativiteten engagerar kroppsminnen och underlättar bearbetningen. I diskussionen presenteras tankar kring undersökningens utformning, bildterapins position som traumabehandlande metod och den brist på forskning som gör att bildterapin saknar erkännande.
The purpose of this study was to visualize how arttherapists work with adults suffering from PTSD, and how differences and similarities in the approaches are expressed. The aim was also to find out more about how arttherapy in PTSD is conducted as well as what aspects the therapists themselves consider to be active parts of the treatment. The issues were: a) Do arttherapists operate differently in PTSD than with other problems? b) What elements in the therapeutic work are especially effective with PTSD, according to the arttherapists? The method consists of semi-structured interviews with six artherapists, all with experience in meeting patients with PTSD. Five interviews were made through personal meetings and one via Skype. The interviews were recorded digitally, transcribed and then processed through Thematic Analysis. The results of the survey shows that arttherapists maintain their therapeutic method regardless of the patient’s problems but that their approaches change when PTSD is known from the start of the therapy. In arttherapy with PTSD arttherapists notice several crucial factors, e.g. the created image as an important part, as well as creativity that involves embodied memories and facilitate processing. The discussion presents thoughts on the survey design, arttherapy's position as treatment in PTSD and the lack of research that makes art therapy failing to receive recognition.

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Barazzone, Natalie. "Attachment, trauma and PTSD." Thesis, Canterbury Christ Church University, 2014. http://create.canterbury.ac.uk/12844/.

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Eye Movement Desensitisation and Reprocessing (EMDR) therapy is a recommended treatment for Post-Traumatic Stress Disorder (PTSD). Despite its rapidly growing evidence base, relatively little is known about its treatment effects beyond improving PTSD symptoms. This preliminary study aimed to explore the capacity for EMDR to facilitate a change in attachment security in a clinical sample of adults experiencing symptoms of PTSD and Complex PTSD (CPTSD). It also explored the role of the therapeutic alliance. A within-subject, repeated-measures design was used. Participants received 10 EMDR sessions on average, as part of their routine care. Self-report measures of attachment, PTSD, CPTSD, and the therapeutic alliance were administered during therapy. No significant changes in attachment were observed; however, there was a trend in the expected direction. A significant reduction in PTSD scores was found, in addition to some associations between change in attachment security and change in PTSD and CPTSD symptoms. No significant relationship between the strength of the therapeutic alliance and attachment change was found. This study contributes to the emerging literature on change in attachment; however, the findings should be interpreted with caution due to limitations including the small sample size. Clinical implications and recommendations for future research are discussed.

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Cole, Hannah. "Post-Traumatic Stress Disorder (PTSD) in people with psychosis : acceptability of PTSD interventions and the prevalence and risk factors of psychosis-related PTSD." Thesis, University of East Anglia, 2018. https://ueaeprints.uea.ac.uk/69798/.

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Background: This portfolio contains two systematic reviews and several meta-analyses in the clinical field of psychosis and trauma. The aim of the first review was to synthesise findings relating to the acceptability of post-traumatic stress disorder (PTSD) treatments in people with psychosis. The aim of the second review was to synthesise and meta-analyse the prevalence figures and risk factors for psychosis-related PTSD (PR-PTSD). Methods: The reviews were conducted using narrative and meta-analytic techniques. Search processes followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results and Conclusion: Detailed statistics are presented for each review. The first review found that PTSD treatments are generally acceptable in people with psychosis. Non-participation rates were low, feedback about the tolerability of treatments was generally good and dropout rates were comparable to other PTSD treatment studies. The second review largely agrees with earlier studies' conclusion that the evidence base for PR-PTSD as it stands makes it difficult to draw conclusions about prevalence rates. Hopefully, as awareness is raised into the issue of PR-PTSD firmer assessment processes will emerge, leading to more robust meta-analytic findings and research syntheses in the future.

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Zöllner, Tanja. "Posttraumatic growth in accident survivors with and without PTSD and after successful PTSD treatment /." [S.l.] : [s.n.], 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000282952.

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Suzanna, Knezevic, and Degon Elin. "PTSD : Något som berör polisen?" Thesis, Umeå University, Basic training programme for Police Officers, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-27353.

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När en svår händelse gör det besvärligt eller omöjligt att leva ett normalt liv kan det röra sig om posttraumatiskt stressyndrom (PTSD). Syndromet kan utvecklas efter att man blivit utsatt eller bevittnat en traumatisk händelse som orsakat fysiska eller psykiska skador eller då en person känt sig allvarligt hotad. Vi har i vår studie undersökt om poliser kan ge uttryck av samma symtom som uppvisas då en person diagnostiseras av Posttraumatiskt stressyndrom. Vi har tagit del av en mängd litteratur och artiklar samt gjort en enkätstudie på några poliser där resultatet visade att poliser kommer i kontakt med påfrestande händelser som ibland lämnar efterverkningar. I arbetet har vi därefter diskuterat om det kan föreligga en koppling mellan kriminalitet och PTSD även hos poliser så som tidigare studier har uppgett föreligga som orsak till vissa brott. Eftersom anmälningar om övervåld förekommer mot polisen kan det vara en intressant koppling om poliser som utsätts för akut stress och har erfarenhet av något som denne upplevt som allvarligt och traumatiserande, kan reagera med mer våld än vad situationen kräver. Vår slutsats är att det inte alltid uppenbart hur en person mår eftersom symtom undertrycks eller döljs för många på arbetsplatsen men istället kanske tar sin tillflykt på hemmaplan, i alkohol eller narkotikamissbruk, utåtagerande mot familj eller våld i ingripanden som hade kunnat undvikas.

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Clark, E. A., Sarah A. Job, Stacey L. Williams, and M. F. Deitz. "PTSD Symptoms and U.S. Veterans." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/8050.

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Книги з теми "PTBD"

Kato, Nobumasa, Mitsuhiro Kawata, and Roger K. Pitman, eds. PTSD. Tokyo: Springer Japan, 2006. http://dx.doi.org/10.1007/4-431-29567-4.

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Porter, Shirley. Treating PTSD. New York : Routledge, 2018.: Routledge, 2018. http://dx.doi.org/10.4324/9781315123066.

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Craig, Gary. EFT for PTSD. Santa Rosa, CA: Energy Psychology, 2008.

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What nurses know-- PTSD. New York: Demos Health Pub., 2012.

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Alford, C. Fred. Trauma, Culture, and PTSD. New York: Palgrave Macmillan US, 2016. http://dx.doi.org/10.1057/978-1-137-57600-2.

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Miller, Laurence. PTSD and Forensic Psychology. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-09081-8.

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Vermetten, Eric, Dewleen G. Baker, and Victoria B. Risbrough, eds. Behavioral Neurobiology of PTSD. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-94824-9.

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Haaken, Janice. Psychiatry, Politics and PTSD. New York, NY : Routledge, 2020.: Routledge, 2020. http://dx.doi.org/10.4324/9781003010913.

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Stocker, Susan. Many faces of PTSD. Uniontown, Ohio: Holy Macro!, 2010.

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Davis, F. A. Hermimer BOCES PTD and PTE 2nd Year PTB: Herkimer County BOCES. Davis Company, F. A., 2021.

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Частини книг з теми "PTBD"

Parris, Kerry M., and Shamanthi M. Jayasooriya. "Prenatal Risk Assessment for Preterm Birth in Low-Resource Settings: Infection." In Evidence Based Global Health Manual for Preterm Birth Risk Assessment, 31–39. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-04462-5_5.

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AbstractMaternal infections are a risk factor for preterm birth (PTB); 40% to 50% of PTBs are estimated to result from infection or inflammation. Higher infection rates are reported in low- and middle-income countries (LMIC), and over 80% of PTBs occur in these settings. Global literature was synthesised to identify infections whose prevention or treatment could improve maternal and neonatal health outcomes and/or prevent mother-to-child transmission of infections.Best evidenced risk factors for PTB were maternal infection with human immunodeficiency virus (HIV) (OR2.27; 95%CI: 1.2–4.3), syphilis (OR2.09; 95%CI:1.09–4.00), or malaria (aOR3.08; 95%CI:1.2–4.3). Lower certainty evidence identified increased PTB risk with urinary tract infections (OR1.8; 95%CI: 1.4–2.1), sexually transmitted infections (OR1.3; 95%CI: 1.1–1.4), bacterial vaginosis (aOR16.4; 95%CI: 4.3–62.7), and systemic viral pathogens.Routine blood testing and treatment are recommended for HIV, hepatitis B virus, and syphilis, as well as for malaria in areas with moderate to high transmission. In high-risk populations and asymptomatic or symptomatic disease, screening for lower genital tract infections associated with PTB should be offered at the antenatal booking appointment. This should inform early treatment and management. Heath education promoting pre-pregnancy and antenatal awareness of infections associated with PTB and other adverse pregnancy outcomes is recommended.

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de Kloet, E. Ronald, and Melly S. Oitzl. "Cortisol and PTSD: Animal Experiments and Clinical Perspectives." In PTSD, 13–27. Tokyo: Springer Japan, 2006. http://dx.doi.org/10.1007/4-431-29567-4_2.

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McAllister-Williams, R. Hamish, Daniel Bertrand, Hans Rollema, Raymond S. Hurst, Linda P. Spear, Tim C. Kirkham, Thomas Steckler, et al. "PTSD." In Encyclopedia of Psychopharmacology, 1100. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_4490.

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Braun-Falco, Markus, Henry J. Mankin, Sharon L. Wenger, Markus Braun-Falco, Stephan DiSean Kendall, Gerard C. Blobe, Christoph K. Weber, et al. "PTSD." In Encyclopedia of Molecular Mechanisms of Disease, 1752. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_7643.

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Porter, Shirley. "Introduction." In Treating PTSD, 1–6. New York : Routledge, 2018.: Routledge, 2018. http://dx.doi.org/10.4324/9781315123066-1.

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Porter, Shirley. "Gathering Tools for the Journey." In Treating PTSD, 103–28. New York : Routledge, 2018.: Routledge, 2018. http://dx.doi.org/10.4324/9781315123066-10.

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Porter, Shirley. "Beginning the Climb—Trauma Processing." In Treating PTSD, 129–57. New York : Routledge, 2018.: Routledge, 2018. http://dx.doi.org/10.4324/9781315123066-11.

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Porter, Shirley. "Preparing Clients for Counseling Termination." In Treating PTSD, 159–65. New York : Routledge, 2018.: Routledge, 2018. http://dx.doi.org/10.4324/9781315123066-12.

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Porter, Shirley. "A Brief History of Our Understanding of Trauma." In Treating PTSD, 9–18. New York : Routledge, 2018.: Routledge, 2018. http://dx.doi.org/10.4324/9781315123066-2.

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Porter, Shirley. "Trauma Foundations." In Treating PTSD, 19–28. New York : Routledge, 2018.: Routledge, 2018. http://dx.doi.org/10.4324/9781315123066-3.

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Тези доповідей конференцій з теми "PTBD"

Kulkarni, A., V. Kulkarni, M. Kulkarni, and A. Deshpande. "LATE PRESENTATION OF POST ROAD TRAFFIC ACCIDENT WITH COMPLETE COMMON BILE DUCT TRANSECTION MANAGED BY PTBD GUIDED RENDEVOUS BILIARY DRAINAGE." In ESGE Days 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1745226.

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Orprayoon, T., P. Kongkam, C. Boonmee, P. Sodarat, O. Seabmuangsai, R. Romano, S. Jangsirikul, et al. "COMBINATION OF ERCP AND EUS-GUIDED BILIARY DRAINAGE (CERES) VERSUS PTBD FOR MALIGNANT HILAR BILIARY OBSTRUCTION: A MULTICENTER PROSPECTIVE COMPARATIVE COHORT STUDY (THE CERES STUDY)." In ESGE Days 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1681446.

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Ginestet, C., S. Geyl, R. Legros, V. Hummel, F. Sanglier, A. Rouchaud, H. Lepetit, et al. "EUS-Guided Biliary Drainage With Electrocautery-Enhanced Lumen-Apposing Metal Stent Placement Should Replace Ptbd After ERCP Failure In Patients With Distal Tumoral Biliary Obstruction: Retrospective Study." In ESGE Days 2021. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1724913.

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Orprayoon, Theerapat, Pradermchai Kongkam, Chaloemphon Boonmee, Passkorn Sodarat, Orathai Seabmuangsai, Rommel Romano, Sureeporn Jangsirikul, et al. "IDDF2019-ABS-0142 Combination of ERCP and EUS-guided biliary drainage (CERES) versus PTBD for malignant hilar biliary obstruction: a multicenter prospective comparative cohort study (the CERES study)." In International Digestive Disease Forum (IDDF) 2019, Hong Kong, 8–9 June 2019. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2019. http://dx.doi.org/10.1136/gutjnl-2019-iddfabstracts.8.

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Fernandez, Michael, Joy Vink, Ronald Wapner, Kyoko Yoshida, and Kristin M. Myers. "Direct Measurement of Human Cervical Tissue Permeability." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80749.

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The mechanical integrity of the uterine cervix is critical for the full-term success of a pregnancy. It must be strong to retain the fetus throughout gestation and then undergo a remodeling and softening process before labor to allow dilation and delivery. We hypothesize that the preterm birth (PTB) condition known as cervical insufficiency (CI) is related to a weak or soft cervix. Such PTBs are responsible for infant developmental problems and in severe cases, infant mortality. To understand the etiologies of CI, our overall research goal is to investigate the mechanical behavior of the cervix. As a foundation for future in-vivo tools to assess cervical softness, we aim to quantify cervical structure-material property relationships for nonpregnant (NP) and pregnant (PG) tissue from women with different obstetric backgrounds, including women with a previous history of CI. The goal of this study is to characterize cervical tissue as a poroelastic (biphasic) material. Here we present the results of two mechanical experiments on NP and PG hysterectomy cervical tissue samples: first, confined compression and second, direct measurement of permeability by a custom strain-adjustable permeation rig.

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Farrelly, Kyra, Pablo Romero-Sanchiz, Ioan Mahu, Sean Barrett, Pamela Collins, Daniel Rasic, and Sherry Stewart. "Do Cannabis Use Motives Mediate the Relationship between PTSD Symptoms and Cannabis Craving to Trauma Cues?" In 2020 Virtual Scientific Meeting of the Research Society on Marijuana. Research Society on Marijuana, 2021. http://dx.doi.org/10.26828/cannabis.2021.01.000.27.

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Cannabis use is common in individuals with posttraumatic stress disorder (PTSD). The PTSD-cannabis relationship is important as cannabis use can worsen PTSD outcomes. Cannabis use motives are a useful construct for understanding the PTSD-cannabis relationship. Frequent pairing of a trauma cue with substance use to cope can lead to conditioned substance craving. The extant research has not yet examined potential mechanisms to explain this effect. We recruited 51 cannabis users with a trauma history for a cannabis cue-reactivity study to examine coping motives as a potential mediator of the hypothesized relationship between PTSD symptoms and cannabis craving to trauma cues. Participants first completed a validated cannabis use motives measure. They were then exposed to a personalized audio and visual cue based on their trauma experience and reported on their cannabis craving immediately following using a standardized measure. Coping motives were contrasted with enhancement motives as the mediator. Results supported our first hypothesis: PTSD symptoms were associated with increased cannabis craving following personal trauma cue exposure. However, our second hypothesis of an indirect effect through coping motives was not supported. We did find an independent main effect of coping motives on cannabis craving triggered by trauma cue exposure. The lack of an interaction between PTSD symptoms and coping motives on trauma-cue induced craving is potentially due to other factors we did not examine that help strengthen the relationship (e.g., sleep). These findings have important clinical implications for targeting both PTSD symptoms and coping motives to prevent the development of conditioned cannabis craving to trauma reminders.

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Bordalo, Sergio N., Celso K. Morooka, Luan G. Tochetto, Renato Pavanello, Gangbing Song, and John C. Bartos. "Experimental Assessment of the Behaviour of a Pipe Vibration Damper Underwater." In ASME 2014 33rd International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/omae2014-23661.

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Submarine petroleum pipelines, risers and jumpers suffer static and dynamic loads due to sea currents and waves, due to the displacements of the floating production units and due to the internal flow, among other causes. Mitigating the oscillations caused by such excitations is critical to the reliability and fatigue of those underwater bodies. The Pounding Tuned Mass Damper (PTMD) is one device that may be employed to absorb and dissipate vibrations. These devices have long been used for mechanical systems operating in the atmosphere, but are new for underwater applications. This paper presents a study of the behaviour of a PTMD working underwater. A small scale laboratory apparatus was built to assess the effect of the absorber on the oscillation of a pipe submerged in a water tank. The PTMD was attached to a test pipe section mounted on an elastic suspension harness. The PTMD model is a lumped mass-spring attachment similar to a tuned mass dumper (TMD) suppressor, but with the addition of a pounding layer, which limits the motion of the PTMD mass, dissipating the energy of the oscillating pipe through the impact of the PTMD mass against that layer. Free and forced oscillation experiments were executed in air and in water, with and without the oscillation absorber, to determine the effectiveness of the PTMD. The tests were run on a range of excitation frequencies and the amplification factors were obtained for each case. The data show a remarkable influence of the surrounding media on the dynamics of the pipe-absorber system, therefore the interaction with the water must be taken into consideration in the design of the system. Although the results are only a preliminary step on the development of a device applicable to an actual petroleum submarine pipeline, it was observed that the PTMD does indeed suppress the vibrations, but it must be properly configured to achieve an optimum performance. The data gathered from this work will also be useful in the improvement of a numerical model of the pipe-PTMD system for use in a computer simulator.

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Patil, Devendra, Akshay Kalia, Gangbing Song, and Marcus Lara. "Pounding Tuned Mass Damper (PTMD): An Innovative Damper for Subsea Pipeline and Jumper Vibration Controls." In ASME 2017 India Oil and Gas Pipeline Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/iogpc2017-2418.

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This paper discusses the pounding tuned mass damper (PTMD) — a novel device developed in a joint collaboration between OneSubsea, a Schlumberger Company and the University of Houston to absorb and dissipate the undesired vibrations generated due to VIV and FIV in subsea pipeline and jumpers. The PTMD is based on principles of both the tuned mass damper (TMD) and the impact damper. The tuned mass in the PTMD absorbs the kinetic energy of the structure and dissipates the absorbed energy through collisions on viscoelastic material. During development, detailed numerical analysis and experimentation were performed to study the effectiveness of the PTMD on the jumper. In the experiment, a full size M-shaped jumper was tested in both air and shallow water conditions for VIV at NASA’s Natural Buoyancy Laboratory (NBL). The experiment also examined the robustness of PTMD for different frequency VIVs. Experimental results showed that the PTMD effectively reduced the in-plane and out-plane vibration of the jumper up to 90%. The observed reduction in vibration amplitude can reduce fatigue damage to jumpers, thus enabling oil and gas operators to optimize spending on vibration mitigation devices, minimize lost revenues, improve system lifespan and availability, and enhance operational flexibility. Reduction in stress of these pipelines also means improved reliability and reduction in costs associated with inspection, maintenance, and repair of subsea jumpers and pipelines. These long-term financial benefits and ability to be installed on existing and new jumpers (pipelines) makes the PTMD a desired solution for vibration suppression in deep water environments.

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Kim, Jeongho, Shahroz Tariq, and Simon S. Woo. "PTD." In SAC '22: The 37th ACM/SIGAPP Symposium on Applied Computing. New York, NY, USA: ACM, 2022. http://dx.doi.org/10.1145/3477314.3507036.

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Anikina, Varvara O., Svetlana S. Savenysheva, and Mariia E. Blokh. "ANXIETY, DEPRESSION OF PREGNANT WOMEN DURING COVID-19 PANDEMIC: ARTICLE REVIEW." In International Psychological Applications Conference and Trends. inScience Press, 2021. http://dx.doi.org/10.36315/2021inpact016.

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"The article is the review of the available research papers on anxiety, depression, stress and signs of PTSD in pregnant women during the COVID-19 pandemic. Articles were searched in the databases of Scopus, Web of Science, EBSCO, APA using the keywords ""pregnancy"", ""COVID-19"", ""anxiety"","" depression"","" stress"","" PTSD"". For this article review we selected only those research studies that have comparatively large samples, with the most widely used measures: State and Trait Anxiety Inventory (STAI), Generalized Anxiety Disorder (GAD-7), Edinburg Postpartum Depression Scale (EPDS), and Impact of a Traumatic Event Scale (IES-R). In these studies levels of anxiety, depression and PTSD are either compared to the existing cut-off scores for these disorders in the literature or in COVID-19 and pre-COVID cohorts of pregnant women. Some papers include not only women during pregnancy but also postpartum. Data here are presented only on pregnancy. The results show that 22% to 68% of pregnant women experience moderate to severe anxiety, and it is two to five times more than the prevalence of anxiety in the literature. The state anxiety has increased more compared to trait anxiety. 14.9%-34.2% of women report on clinically significant levels of depression, and it is twice higher than the pre-existing data. About 10.3% of pregnant population have PTSD signs which falls into a moderate range. The levels of anxiety, depression and PTSD are significantly higher in COVID-19 cohorts than in pre-COVID samples. The most predicting factor for anxiety, depression and PTSD is the pre-existing mental health disorder of anxiety or depression."

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Звіти організацій з теми "PTBD"

Germain, Anne, and Eric A. Nofzinger. Efficacy of Adjunct Sleep Interventions for PTSD (EASI-PTSD). Fort Belvoir, VA: Defense Technical Information Center, March 2010. http://dx.doi.org/10.21236/ada542260.

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Marmar, Charles R. Biomarkers for PTSD. Fort Belvoir, VA: Defense Technical Information Center, July 2010. http://dx.doi.org/10.21236/ada618637.

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Marmar, Charles. Biomarkers for PTSD. Fort Belvoir, VA: Defense Technical Information Center, July 2011. http://dx.doi.org/10.21236/ada618638.

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Marmar, Charles R. Biomarkers for PTSD. Fort Belvoir, VA: Defense Technical Information Center, July 2012. http://dx.doi.org/10.21236/ada619951.

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O’Neil, Maya E., Tamara P. Cheney, Yun Yu, Erica L. Hart, Rebecca S. Holmes, Ian Blazina, Stephanie P. Veazie, et al. Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: 2022 Update of the PTSD Repository Evidence Base. Agency for Healthcare Research and Quality (AHRQ), October 2022. http://dx.doi.org/10.23970/ahrqepcptsd2022.

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Objectives. Identify and abstract data from randomized controlled trials (RCTs) examining treatment for posttraumatic stress disorder (PTSD) and comorbid PTSD/substance use disorder to update the previous Agency for Healthcare Research and Quality (AHRQ) report and National Center for PTSD (NCPTSD) PTSD Trials Standardized Data Repository (PTSD-Repository). Data sources. We searched PTSDpubs, Ovid® MEDLINE®, Cochrane CENTRAL, PsycINFO®, Embase®, CINAHL®, and Scopus® for eligible RCTs published from June 1, 2018, to January 26, 2022. Review methods. In consultation with AHRQ and NCPTSD, we updated the evidence tables for the PTSD-Repository by including evidence published after publication of the last update and expanding abstraction of results to include calculated standardized effect sizes. The primary publication for each RCT was abstracted; data and citations from secondary publications (i.e., companion papers) appear in the same record. We assessed risk of bias (RoB) for all newly included studies using the Revised Cochrane Risk of Bias 2 (RoB 2) tool for randomized trials. For studies already in the PTSD-Repository, we will add calculated standardized effect sizes and update RoB using the new RoB 2 tool over the next several annual updates. Results. We added 48 new RCTs examining treatments for PTSD, for a total of 437 included studies published from 1988 to July 30, 2021. Among the 48 newly added RCTs, psychotherapy interventions were the most commonly employed (50%), followed by complementary and integrative health (17%). Approximately half of studies were conducted in the United States (46%), and enrolled community participants (52%) and participants with a mix of trauma types (48%). Studies typically had sample sizes ranging from 25 to 99 participants (69%). RoB was rated as high for 52 percent of studies, 31 percent were rated as low RoB, and the remaining studies were rated as having some concerns (15%). Conclusions. This report updates the previous AHRQ report to include 48 recently published RCTs, for a total of 437 studies. This update adds comprehensive data, standardized effect sizes for PTSD outcomes, and RoB assessment for the newly included RCTs. As with the previous AHRQ update, this report will inform updates to the PTSD-Repository, a comprehensive database of PTSD trials.

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Najavits, Lisa M. PTSD and Substance Abuse. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada609388.

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Najavits, Lisa. PTSD and Substance Abuse. Fort Belvoir, VA: Defense Technical Information Center, July 2012. http://dx.doi.org/10.21236/ada568227.

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Najavits, Lisa. PTSD and Substance Abuse. Fort Belvoir, VA: Defense Technical Information Center, August 2011. http://dx.doi.org/10.21236/ada618639.

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Marmar, Charles R. Validating Biomarkers for PTSD. Fort Belvoir, VA: Defense Technical Information Center, April 2015. http://dx.doi.org/10.21236/ada620325.

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Cao, Xianling, Xuanyou Zhou, Naixin Xu, Songchang Chang, and Chenming Xu. Association of IL-4 and IL-10 Polymorphisms with Preterm Birth Susceptibility: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0044.

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Review question / Objective: The aim of our systematic review and meta-analysis was to summarize the effects of IL-4 and IL-10 gene polymorphism and clarify their possible association with PTB. Condition being studied: World Health Organization (WHO) defines preterm birth (PTB) as babies born alive before 37 weeks of pregnancy are completed. The new estimates show that the prevalence of PTB during 2014 ranged from 8.7% to13.4% of all live births, about 15 million preterm babies born each year. Besides, PTB is the leading cause of death worldwide for children below 5 years of age. Babies born preterm are at an increased risk of short-term and long-term complications attributed to immaturity of multiple organ systems, such as cerebral palsy, intellectual disabilities, vision and hearing impairments, and impaired cognitive development. PTB has become a worldwide public health problem, but its etiology remains unclear. Accumulating evidence shows that PTB is a syndrome that can be attributed to a variety of pathological processes(5). Inflammatory diseases and genetic background are known risk factors for PTB, many studies had shown that genetic variations in proinflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1 α (IL-1 α) are associated with increased risk of PTB, but the relationship between genetic polymorphism in anti-inflammatory cytokines and risk of PTB remains controversial.

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