Добірка наукової літератури з теми "Production de ROS"
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Статті в журналах з теми "Production de ROS":
Brand, M. "Mitochondrial ROS production." Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 146, no. 4 (April 2007): S56—S57. http://dx.doi.org/10.1016/j.cbpa.2007.01.044.
Hole, Paul S., Lorna Pearn, Amanda J. Tonks, Philip E. James, Alan K. Burnett, Richard L. Darley, and Alex Tonks. "Ras-induced reactive oxygen species promote growth factor–independent proliferation in human CD34+ hematopoietic progenitor cells." Blood 115, no. 6 (February 11, 2010): 1238–46. http://dx.doi.org/10.1182/blood-2009-06-222869.
Kobayashi, Y., X. Qi, and G. Chen. "MK2 Regulates Ras Oncogenesis through Stimulating ROS Production." Genes & Cancer 3, no. 7-8 (July 1, 2012): 521–30. http://dx.doi.org/10.1177/1947601912462718.
Jia, Rui. "Probing the Production of Intracellular Vesicles Containing Reactive Oxygen and Nitrogen Species by Electrochemical Resistive-pulse Sensing." Electrochemical Society Interface 31, no. 4 (December 1, 2022): 43–44. http://dx.doi.org/10.1149/2.f07224if.
Pino, José A., Nelson Osses, Daniela Oyarzún, Jorge G. Farías, Ricardo D. Moreno, and Juan G. Reyes. "Differential effects of temperature on reactive oxygen/nitrogen species production in rat pachytene spermatocytes and round spermatids." REPRODUCTION 145, no. 2 (February 2013): 203–12. http://dx.doi.org/10.1530/rep-12-0330.
N. Agbedanu, Prince, Troy B. Puga, Joshua Schafer, Pearce Harris, Gary Branum, and Nora Strasser. "Investigation of Reactive Oxygen Species production in Human Hepatocytes." Gastroenterology Pancreatology and Hepatobilary Disorders 6, no. 2 (January 12, 2022): 01–06. http://dx.doi.org/10.31579/2641-5194/058.
Ito, Seigo, Hiroyuki Nakashima, Takuya Ishikiriyama, Masahiro Nakashima, Akira Yamagata, Toshihiko Imakiire, Manabu Kinoshita, Shuhji Seki, Hiroo Kumagai, and Naoki Oshima. "Effects of a CCR2 antagonist on macrophages and Toll-like receptor 9 expression in a mouse model of diabetic nephropathy." American Journal of Physiology-Renal Physiology 321, no. 6 (December 1, 2021): F757—F770. http://dx.doi.org/10.1152/ajprenal.00191.2021.
Doering, Talisa, Justin Maire, Wing Yan Chan, Alexis Perez-Gonzalez, Luka Meyers, Rumi Sakamoto, Isini Buthgamuwa, Linda L. Blackall, and Madeleine J. H. van Oppen. "Comparing the Role of ROS and RNS in the Thermal Stress Response of Two Cnidarian Models, Exaiptasia diaphana and Galaxea fascicularis." Antioxidants 12, no. 5 (May 6, 2023): 1057. http://dx.doi.org/10.3390/antiox12051057.
Wojtovich, Andrew P., and Thomas H. Foster. "Optogenetic control of ROS production." Redox Biology 2 (2014): 368–76. http://dx.doi.org/10.1016/j.redox.2014.01.019.
Garama, Daniel J., Tiffany J. Harris, Christine L. White, Fernando J. Rossello, Maher Abdul-Hay, Daniel J. Gough, and David E. Levy. "A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3." Molecular and Cellular Biology 35, no. 21 (August 17, 2015): 3646–56. http://dx.doi.org/10.1128/mcb.00541-15.
Дисертації з теми "Production de ROS":
Bergman, Malin, and Emma Flodin. "Dagens Polis- Ros eller Ris? : En kvalitativ studie om polisers upplevelser av myndighetens omorganisation." Thesis, Högskolan i Halmstad, Akademin för hälsa och välfärd, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-40038.
Unsuccessful organizational changes can imply risks that include anxiety, stress and conflicts within the agency. While the management expects the agency to function as it always has, it is not uncommon for the implementation work to be imposed on the employees. Therefore, there is a risk that organizational changes can have consequences that results in people resigning. This bachelor's thesis aims to examine how the reorganization of the Swedish police which implemented on January 1, 2015 is experienced by cops in Intervention activities. Furthermore, we also intended to create an understanding for how police work has been affected by this particular organizational change. What makes our study unique is that it in a nuanced way highlights new aspects of the reorganization from a sociological approach directed on the police officers own emotions and experiences related to the organizational change. The theories we have chosen to start from deal with organizational change from a structural perspective, but also at the individual level. The organizational models Lean Production, The Bureaucratic organizational form and The organizational change theory we have chosen to apply to create an understanding of how the police experience the reorganization's business idea in practice. We have also used the theories Alienation and The struggle to Recognition to gain a deeper understanding of how the police experience that the reorganization has affected their work and working conditions. Our sociological analysis will be based on all theories, scientific articles and the empirical compilation through a detailed discussion in relation to each other. Our study had been based on a qualitative approach through which we collected the empirical data by semi-structured interviews. The collected empirics, associated with our theoretical basis, formed the foundation for our analysis as well as our concluding reflections and conclusions. The most comprehensive conclusion we can compose from the police officers personal experiences of the reorganization, is that there was a deficient communication and information related to the reform that constituted resistance and frictions within the agency.
Eduafo, Augusta K. "Mechanisms of Hyperglycemia-Induced ROS Production in Osmotically Swollen Glial Cells." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1433185840.
Bell, Amy. "The response of the mitochondrial proteome and ROS production to ageing and dietary restriction." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3179.
Messenger, David James. "Impact of UV light on the plant cell wall, methane emissions and ROS production." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4347.
Emami-Shahri, Nia. "The voltage-gated proton channel HVCN1 modulates mitochondrial ROS production and inflammatory response in macrophages." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8036.
Silva, Cátia Liliana Marques da. "Dissecting the role of Profilin-1 in microglial cell function: the impact on ROS production." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15607.
Microglial cells are the resident immune cells of central nervous system (CNS) and the major players in neuroinflammation. These cells are also responsible for surveilling the neuronal microenvironment, and upon injury to the CNS they change their morphology and molecular profile and become activated. Activated status is associated with microglia proliferation, migration to injury foci, increased phagocytic capacity, production and release of reactive oxygen species (ROS), cytokines (pro- or anti-inflammatory) and reactive nitrogen species. Microglia activation is crucial for tissue repair in the healthy brain. However, their chronic activation or deregulation might contribute for the pathophysiology of neurodegenerative diseases. A better understanding of the mechanisms underlying microglial cell activation is important for defining targets and develop appropriate therapeutic strategies to control the chronic activation of microglia. It has been observed an increase in profilin (Pfn) mRNA in microglial cells in the rat hippocampus after unilateral ablation of its major extrinsic input, the entorhinal cortex. This observation suggested that Pfn might be involved in microglia activation. Pfn1 is an actin binding protein that controls assembly and disassembly of actin filaments and is important for several cellular processes, including, motility, cell proliferation and survival. Here, we studied the role of Pfn1 in microglial cell function. For that, we used primary cortical microglial cell cultures and microglial cell lines in which we knocked down Pfn1 expression and assessed the activation status of microglia, based on classical activation markers, such as: phagocytosis, glutamate release, reactive oxygen species (ROS), pro- and anti-inflammatory cytokines. We demonstrated that Pfn1 (i) is more active in hypoxia-challenged microglia, (ii) modulates microglia pro- and anti-inflammatory signatures and (iii) plays a critical role in ROS generation in microglia. Altogether, we conclude that Pfn1 is a key protein for microglia homeostasis, playing an essential role in their activation, regardless the polarization into a pro or anti-inflammatory signature.
As células da microglia são células imunes residentes no sistema nervoso central (SNC) e desempenham um papel importante em processos neuroinflamatórios. Estas células são responsáveis por monitorizar o parênquima neuronal, sendo capazes de responder rapidamente a danos no SNC. Após ativação, a microglia altera a sua morfologia e o seu perfil de expressão de proteínas. O processo de ativação induz a proliferação, migração para a foco da lesão, aumento da capacidade fagocítica, bem como produção e libertação de espécies reativas de oxigénio (EROs), espécies reativas de azoto e citocinas (pro- e anti-inflamatórias). A ativação da microglia é essencial para a reparação de tecidos e a manutenção da homeostasia do SNC. No entanto, a ativação crónica ou a sua desregulação podem contribuir para a patofisiologia de doenças neurodegenerativas. Assim sendo, o estudo dos mecanismos subjacentes à ativação das células da microglia é importante para ajudar a definir e desenvolver estratégias terapêuticas apropriadas para prevenir a sua ativação crónica. Um estudo anterior reportou o aumento dos níveis de RNAm da profilina (Pfn) em células da microglia no hipocampus de ratos após lesão unilateral no córtex entorrinal, sugerindo que a Pfn poderá estar envolvida no processo de ativação da microglia. A Pfn1 é uma proteína de ligação à actina que regula a polimerização do citoesqueleto de actina, sendo importante em diversos processos celulares, incluindo motilidade, proliferação e sobrevivência. Neste trabalho, nós estudamos o papel da Pfn1 na função da microglia. Para tal, utilizamos linhas celulares e células primárias de microglias corticais de rato nas quais reduzimos a expressão da Pfn1 e avaliamos o seu estado de ativação com base em marcadores clássicos de ativação, tais como: fagocitose, libertação de glutamato, produção e libertação de EROs e citocinas pro- e anti-inflamatórias. Nós demonstramos que a Pfn1 (i) se encontra mais ativa após estímulo da microglia por hipoxia, (ii) modula as assinaturas pro- e anti-inflamatória da microglia e (iii) desempenha um papel importante na produção de EROs pela microglia. Nesse estudo concluímos que a Pfn1 é uma proteína importante para o funcionamento da microglia, desempenhando um papel essencial na ativação da microglia, independentemente da polarização pró ou anti-inflamatória.
Trein, Marcia Rodrigues. "Síntese e atividade anti-Trichomonas vaginalis de chalconas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/164467.
Trichomoniasis is the most common non-viral sexually transmitted disease worldwide and can lead to serious consequences in reproductive health, cancer and HIV acquisition. For this reason, this infection results in a heavy burden for public health systems. Current approved treatment, which consists in 5-nitromidazole drugs, metronidazole and tinidazole, present adverse effects and there is underestimate drug resistance data on this parasitic infection, currently considered a neglected disease. Therefore, there is an urgent need for new alternatives for trichomoniasis treatment. Chalcones are a family of molecules that present various biological applications, such as activity against many pathogenic organisms including protozoan pathogens. This study presents the anti-Trichomonas vaginalis potential of synthetized chalcone derivatives and their effects on the trophozoites. IC50 values of the most active compounds ranged from 27.5 to 76.4 μM, and 4’-hydroxychalcone and 3’- aminochalcone presented the lowest values of IC50 (27.5 and 28.9 μM). These two compounds showed cytotoxicity against HMVII vaginal epithelial cells, thus presenting a low Selectivyty Index; however, when Galleria mellonella larvae were used as model for in vivo toxicity no significant decrease in viability after treatment was observed. The chalcones also did not induce hemolysis in human erythrocytes The compounds did not induce significant reactive oxygen species (ROS) production in the trophozoites. Human neutrophils have increased ROS production when exposed to treated trophozoites. Results indicate that chalcones are a family of molecules with potential activity against T. vaginalis.
Lee, Flaherty Renée. "Stress hormone signalling contributes to tumourigenesis through the production of ROS/RNS, induction of DNA damage and interference with chemotherapy in breast cancer." Thesis, University of Brighton, 2017. https://research.brighton.ac.uk/en/studentTheses/28861765-5215-4dc1-b4c0-f1f8b794d924.
Johansson, Hampus. "Nox2/4 inhibition in NB69 during ischemia/reperfusion : Inhibition of ROS-production using M4, M107, and M114." Thesis, Högskolan i Skövde, Institutionen för hälsa och lärande, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17941.
Singhapol, Chatchawan. "Mitochondrial localisation of hTERT protects against nuclear DNA damage and mitochondrial ROS production after endogenous and exogenous stress." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/2216.
Книги з теми "Production de ROS":
Middaugh, Jeffrey A. A study of the metabolic adaptation provoked by decreased aconitase activity and increased ROS production as a consequence of aluminum stress in Pseudomonas fluorescens. Sudbury, Ont: Laurentian University, School of Graduate Studies, 2004.
Whittier, Jack. Comparative performance analysis, commercial cut-flower rose production. Santa Fe, N.M: New Mexico Research and Development Institute, 1990.
R, Layne Desmond, and Bassi Daniele, eds. The peach: Botany, production and uses. Wallingford, Oxfordshire, UK: CABI, 2008.
Pemberton, H. B. Production of pot roses. Portland, Ore: Timber Press, 1997.
Dikova, Peti︠a︡. Intervi︠u︡ s piesa: "Seks, narkotit︠s︡i i rok&rol" igrae se ot 1992 : istorii︠a︡ta na naĭ-dŭlgo igraniya spektakŭl v edin i sŭsht sŭstav v sveta. Sofii︠a︡: Iztok-Zapad, 2020.
Krajewski, Lee J. Operations management: Strategy and analysis. 3rd ed. Reading, Mass: Addison-Wesley Pub. Co., 1993.
Krajewski, Lee J. Operations management: Strategy and analysis. Reading, Mass: Addison-Wesley, 1987.
(Firm), Caroselli Design. Rodster street rods: Step-by-step assembly manual for the award-winning street rods you build on a modern production vehicle. El Segundo, CA: Caroselli Design, 2003.
Chisick, Harvey. The production, distribution and readership of a conservative journal of the early French Revolution: The Ami du roi of the abbé Royou. Philadelphia: American Philosophical Society, 1992.
Kronja, Ivana. Estetika avangardnog i eksperimentalnog filma: Telo, rod i identitet : Evropa - SAD - Srbija. Beograd: Filmski centar Srbije, 2020.
Частини книг з теми "Production de ROS":
Starkov, Anatoly A. "Measurement of Mitochondrial ROS Production." In Methods in Molecular Biology, 245–55. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-756-3_16.
Kar, Rup Kumar. "ROS Signaling: Relevance with Site of Production and Metabolism of ROS." In Reactive Oxygen Species and Oxidative Damage in Plants Under Stress, 115–25. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20421-5_5.
Starkov, Anatoly A. "Measuring Mitochondrial Reactive Oxygen Species (ROS) Production." In Systems Biology of Free Radicals and Antioxidants, 265–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-30018-9_8.
Allaban, Anas Abou, Devin Bonnie, Emerson Knapp, Prajakta Gokhale, and Thomas Moulard. "Developing Production-Grade Applications with ROS 2." In Studies in Computational Intelligence, 3–54. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-75472-3_1.
Yu, Liping, Brian D. Fink, and William I. Sivitz. "Simultaneous Quantification of Mitochondrial ATP and ROS Production." In Methods in Molecular Biology, 149–59. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2257-4_14.
Pasqualotto, Fábio Firmbach, and Eleonora Bedin Pasqualotto. "Recreational Drugs and ROS Production in Mammalian Spermatozoa." In Studies on Men's Health and Fertility, 417–31. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-776-7_19.
Konno, Tasuku, Cécile Crapart, and Edward Avezov. "H2O2/ROS Production, Consumption, and Transport across Organelles." In Peroxiporins, 54–87. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003160649-6.
Milton, Rosemary H., and Andrey Y. Abramov. "Ischemia-Reperfusion Induces ROS Production from Three Distinct Sources." In Oxidative Neural Injury, 97–108. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-342-8_6.
Sachdev, Swati, Shamim Akhtar Ansari, and Mohammad Israil Ansari. "ROS Production and Function at Plasma Membrane and Apoplast." In Reactive Oxygen Species in Plants, 125–42. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-9884-3_8.
Li, Yida, Han Li, Liuyang Wang, and Man Zhang. "Autonomous Crop Image Acquisition System Based on ROS System." In Sensing Technologies for Field and In-House Crop Production, 53–76. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-7927-1_4.
Тези доповідей конференцій з теми "Production de ROS":
Moulard, Thomas. "Is ROS 2 ready for production? A look at ROS 2 reliability, performance and security improvements." In ROSCon2019FR. Mountain View, CA: Open Robotics, 2019. http://dx.doi.org/10.36288/roscon2019fr-900309.
Moulard, Thomas. "Is ROS 2 ready for production? A look at ROS 2 reliability, performance and security improvements." In ROSCon2019FR. Mountain View, CA: Open Robotics, 2019. http://dx.doi.org/10.36288/roscon2019fr-900853.
Kimmig, L. M., P. Woods, A. Y. Meliton, K. Sun, R. B. Hamanaka, and G. M. Mutlu. "LPS Does Not Induce Mitochondrial ROS Production in Alveolar Macrophages." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5566.
Mittal, M., M. Roth, XQ Gu, R. Schermuly, H. Ghofrani, W. Seeger, F. Grimminger, G. Haddad, and N. Weissmann. "Role of NADPH Oxidase Derived ROS Production in Regulation of Kv Channels." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5124.
Osborn, Heather L., Alan J. Ryan, Ana-Monica Racila, Shubha Murthy, and A. B. Carter. "Rac1 Mediates ROS Production Via Interaction With Cytochrome C In The Mitochondria." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2537.
Yi, X., F. Liu, L. Schweitzer, F. Baghnavi, J. Seufert, and G. Päth. "Knockdown of Etv5 enhances ROS production and impairs viability in pancreatic beta cells." In Diabetes Kongress 2021 – 55. Jahrestagung der DDG. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1727367.
Ferguson, Brent W., Xinsheng Gao, Maciej Zelazowski, Sabine Lange, Martin C. Abba, Richard D. Wood, and C. Marcelo Aldaz. "Abstract 5183: Loss of WWOX induces ANGPTL4 and ROS production in breast cells." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5183.
Waypa, GB, JD Marks, and PT Schumacker. "Hypoxia Increases ROS Signaling in the Cytosol and Mitochondrial Intermembrane Space, While It Decreases ROS Production in the Mitochondrial Matrix: Relationship to HPV." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a6255.
Ji, Yubin, Zhongyuan Qu, Xiang Zou, and Chenfeng Ji. "Effects of Juglone on ROS Production and Mitochondrial Transmembrane Potential in SGC-7901 Cells." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5517683.
Fontana, Diletta, Mario Mauri, Antonio Niro, Luca Massimino, Mayla Bertagna, Giovanni Zambrotta, Mario Bossi, et al. "Abstract 3385: ETNK1 mutations promote ROS production and DNA damage through increased mitochondrial activity." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-3385.
Звіти організацій з теми "Production de ROS":
Paul, Satashree. Oxidative Stress: A Cause of Male Infertility. Science Repository OÜ, October 2020. http://dx.doi.org/10.31487/sr.blog.10.
Prusky, Dov, Martin Dickman, and Robert Fluhr. Effect of pH Modulation and ROS Production by Postharvest Pathogens on Postharvest Disease Development. United States Department of Agriculture, July 2012. http://dx.doi.org/10.32747/2012.7613876.bard.
Horwitz, Benjamin, and Barbara Gillian Turgeon. Secondary Metabolites, Stress, and Signaling: Roles and Regulation of Peptides Produced by Non-ribosomal Peptide Synthetases. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7696522.bard.
Horwitz, Benjamin, and Nicole M. Donofrio. Identifying unique and overlapping roles of reactive oxygen species in rice blast and Southern corn leaf blight. United States Department of Agriculture, January 2017. http://dx.doi.org/10.32747/2017.7604290.bard.
Droby, Samir, Michael Wisniewski, Ron Porat, and Dumitru Macarisin. Role of Reactive Oxygen Species (ROS) in Tritrophic Interactions in Postharvest Biocontrol Systems. United States Department of Agriculture, December 2012. http://dx.doi.org/10.32747/2012.7594390.bard.
Miller, Gad, and Jeffrey F. Harper. Pollen fertility and the role of ROS and Ca signaling in heat stress tolerance. United States Department of Agriculture, January 2013. http://dx.doi.org/10.32747/2013.7598150.bard.
Dickman, Martin B., and Oded Yarden. Modulation of the Redox Climate and Phosphatase Signaling in a Necrotroph: an Axis for Inter- and Intra-cellular Communication that Regulates Development and Pathogenicity. United States Department of Agriculture, August 2011. http://dx.doi.org/10.32747/2011.7697112.bard.
Prusky, Dov, Noel T. Keen, and Stanley Freeman. Elicitation of Preformed Antifungal Compounds by Non-Pathogenic Fungus Mutants and their Use for the Prevention of Postharvest Decay in Avocado Fruits. United States Department of Agriculture, January 1996. http://dx.doi.org/10.32747/1996.7570573.bard.
Droby, Samir, Tim R. Gottwald, Richard Stange, Efraim Lewinsohn, and T. Gregory McCollum. Characterization of the biochemical basis of host specificity of Penicillium digitatum and Penicillium italicum on citrus fruit. United States Department of Agriculture, May 2008. http://dx.doi.org/10.32747/2008.7587726.bard.
Horwitz, Benjamin A., and Barbara Gillian Turgeon. Fungal Iron Acquisition, Oxidative Stress and Virulence in the Cochliobolus-maize Interaction. United States Department of Agriculture, March 2012. http://dx.doi.org/10.32747/2012.7709885.bard.