Готові списки джерел за темами / POEMS syndrom

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Добірка наукової літератури з теми "POEMS syndrom"

Автор: Grafiati

Опубліковано: 8 лютого 2025

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Статті в журналах з теми "POEMS syndrom"

Schwarz, Ricarda, and Marius Horger. "POEMS-Syndrom." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 190, no. 02 (January 18, 2018): 106–10. http://dx.doi.org/10.1055/s-0043-121581.

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Braun, S. A., P. Albrecht, A. Methner, and S. Hanneken. "POEMS-Syndrom." Der Hautarzt 62, no. 10 (September 15, 2011): 722–25. http://dx.doi.org/10.1007/s00105-011-2239-1.

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Cohnen, Mathias, Michael Uppenkamp, Peter Meusers, and Günter Brittinger. "POEMS-Syndrom." Medizinische Klinik 93, no. 11 (November 1998): 678–82. http://dx.doi.org/10.1007/bf03044880.

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Erbslöh-Möller, Brigitte, Boris Perras, and Klaus Sack. "POEMS-Syndrom mit Niereninsuffizienz." Medizinische Klinik 94, no. 3 (March 1999): 159–64. http://dx.doi.org/10.1007/bf03044846.

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Ebhardt, H., T. Eidner, A. Berndt, D. Katenkamp, and H. Kosmehl. "Das POEMS-Syndrom - Ein Fallbericht." Der Pathologe 21, no. 3 (May 29, 2000): 255–59. http://dx.doi.org/10.1007/s002920050397.

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Mäurer, M., and C. Sommer. "POEMS-Syndrom - ungewöhnliche Manifestation mit beidseitigem Charcot-Gelenk." DMW - Deutsche Medizinische Wochenschrift 124, no. 12 (March 25, 2008): 346–50. http://dx.doi.org/10.1055/s-2007-1024305.

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Schaumberg, J., C. Müller-Habich, and A. Müller-Jensen. "POEMS-Syndrom – schwierig zu diagnostizieren – schwierig zu therapieren." Aktuelle Neurologie 37, no. 02 (March 2010): 86–88. http://dx.doi.org/10.1055/s-0029-1223517.

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Birkenbach, A., F. Kühlhorn, M. Grube, H. Helbig, and M. A. Gamulescu. "POEMS-Syndrom als seltene Ursache eines bilateralen Papillenödems." Der Ophthalmologe 114, no. 3 (June 30, 2016): 262–65. http://dx.doi.org/10.1007/s00347-016-0287-8.

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Kurzen, Kunz, and Nigg. "Blauverfärbung der Hände, Taubheitsgefühl an den Füssen, indolente Lymphknotenschwellung zervikal bei einem 73-jährigen Mann." Praxis 95, no. 41 (October 1, 2006): 1589–93. http://dx.doi.org/10.1024/1661-8157.95.41.1589.

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Ein 73-jähriger Patient wurde uns zugewiesen wegen einer Blauverfärbung der Hände. Zusätzlich bestanden anamnestisch und klinisch eine B-Symptomatik, brennende Schmerzen mit Taubheitsgefühl an den Füssen bei Polyneuropathie sowie eine indolente Lymphknotenschwellung zervikal. 1996 und 2001 waren wegen einer lokalisierten angiofollikulären Lympknotenhyperplasie (Castleman-Erkrankung) bereits Halslymphknoten exzidiert worden. Laborchemisch bestanden erhöhte Entzündungszeichen, eine Hypothyreose und eine monoklonale Gammopathie. Die Bildgebung zeigte generalisierte Lymphknotenvergrösserungen zervikal, mediastinal und abdominal sowie eine Splenomegalie. Somit bestand das Vollbild eines POEMS-Syndroms (Sonderform des Multiplen Myeloms) mit Polyneuropathie, Organomegalie (Milz), Endokrinopathie (Schilddrüse), monoklonaler Gammopathie und Skin Changes (Blauverfärbung der Hände). Die generalisierte Lymphadenopathie entsprach histologisch einem Rezidiv der vorbestehenden Castleman-Erkrankung, deren Assoziation mit dem POEMS-Syndrom bekannt ist. Der Patient sprach gut auf die eingeleitete Steroidtherapie an und ist heute weitgehend beschwerdefrei.

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Barry, Jean-Cyriaque, Marc Gleichmann, and Helmut Wilhelm. "Beidseitige Papillenschwellung bei Polyneuropathie, Organomegalies Endokrinopathie, monoklonalen Proteinen und Hautveränderungen (POEMS-Syndrom)." Klinische Monatsblätter für Augenheilkunde 215, no. 07 (July 1999): 59–63. http://dx.doi.org/10.1055/s-2008-1034671.

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Дисертації з теми "POEMS syndrom"

Roussel, Murielle. "Analyse par séquençage ARN à haut débit du répertoire des immunoglobulines : un outil diagnostique dans les gammapathies monoclonales de signification clinique, en particulier dans le syndrome POEMS et l’Amylose AL." Electronic Thesis or Diss., Limoges, 2024. http://www.theses.fr/2024LIMO0097.

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Анотація:

Depuis 2018, nous avons mis en place le séquençage à haut débit sur base ARN (5’RACE-RepSeq) du répertoire des immunoglobulines et nous avons analysé l’ARNm codant pour les immunoglobulines dans plus de 500 patients suspects de maladies liées aux gammapathies, en nous concentrant ici sur l’amylose AL et le syndrome POEMS. Cette technique fournit des informations complètes sur la région V(D)J du répertoire dominant d’immunoglobulines, permettant l’analyse des modèles mutationnels, des fréquences variables des gènes des immunoglobulines et de la diversité résultant de l’hypermutation somatique. Notre analyse, qui intègre des données cliniques, histologiques et biologiques provenant de plus de 90 % des patients, a établi une base de données robuste englobant Amylose AL, POEMS et d'autres gammapathies monoclonales de signification clinique. En tirant parti de cet ensemble de données unique, nous avons démontré que la présence d’un clone IGLV1-36, 1-40 ou 1-44 avec l’un des motifs mutationnels récurrents (P/A/G/D/YS) VNWYQ associé au IGLJ3*02 en cas de suspicion de syndrome POEMS peut être considéré comme un biomarqueur spécifique à 100% avec une précision de 80%. Nous avons également généré de nombreuses données originales dans le contexte de l’Amylose AL : la majorité des patients ont une atteinte cardiaque et rénale avec en médiane 3 organes touchés ; les gènes variables IGLV6-57, IGLV3-1, IGLV1-44, IGLV1-51, et IGKV1-33 (34%), IGKV1-16 (15%), et à moindre mesure IGKV6-21 (5%), sont surreprésentés par rapport aux autres gammapathies monoclonales et au répertoire médullaire polyclonal ; il n’y a pas de corrélation entre l’importance du clone au sein du répertoire médullaire, le gène VL utilisé ni le taux de chaines légères circulantes. Nous avons pu établir des score physicochimiques de chaque séquence qui vont nous permettre d’établir un outil de prédiction de pathogénicité des chaines légères grâce à l’intelligence artificielle
Since 2018, we set up high-throughput sequencing RNA-based Immunoglobulin Repertoire sequencing (5'RACE-RepSeq) and have analyzed immunoglobulin-encoding mRNA in more than 500 patients suspected of gammapathy-related diseases, focusing here on AL amyloidosis and POEMS syndrome. This technique provides comprehensive insights on the V(D)J region of the dominant immunoglobulin repertoire, enabling analysis of mutational patterns, variable immunoglobulin gene frequencies and diversity resulting from somatic hypermutation. Our analysis, which integrates clinical, histological and biological data from over 90% of patients, has established a robust database encompassing AL amyloidosis, POEMS and other clinically significant monoclonal gammopathies. Leveraging this unique dataset, we demonstrated that the presence of an IGLV1-36, 1-40 or 1-44 clone with one of the recurrent mutational motifs (P/A/G/D/YS) VNWYQ associated with IGLJ3*02 in suspected POEMS syndrome can be considered a 100% specific biomarker with 80% accuracy. We have also generated numerous original data in the context of AL Amyloidosis: the majority of patients have cardiac and renal involvement, with a median of 3 organs affected; the variable genes IGLV6-57, IGLV3-1, IGLV1-44, IGLV1-51, and IGKV1-33 (34%), IGKV1-16 (15%), and to a lesser extent IGKV6-21 (5%), are over-represented compared with other monoclonal gammopathies and the polyclonal bone marrow repertoire; there is no correlation between the importance of the clone within the bone marrow repertoire, the VL gene used or the level of circulating light chains. We were able to establish physicochemical scores for each sequence, which will enable us, through Artificial Intelligence, to establish a predicting tool for the pathogenicity of light chains

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Soubrier, Martin. "Le Syndrome POEMS." Clermont-Ferrand 1, 2003. http://www.theses.fr/2003CLF1MM11.

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Rouchon, Dominique. "Aspects particuliers d'un poems syndrome : à propos d'une observation." Bordeaux 2, 1989. http://www.theses.fr/1989BOR25146.

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SALA, ISABELLE. "Le syndrome polyneuropathie organomegalie endocrinopathie : proteine monoclonale et anomalies cutanees." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20328.

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FAVREL, LORAIN AGNES. "Le poems syndrome : revue de la litterature ; presentation de trois observations et discussion." Dijon, 1994. http://www.theses.fr/1994DIJOM106.

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SOUBRIER, MARTIN. "Syndrome p. O. E. M. S. : etude de vingt cas francaise ; revue de la litterature." Clermont-Ferrand 1, 1989. http://www.theses.fr/1989CLF11022.

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Dalbin, Jacques. "Le POEMS syndrome : à propos de deux cas avec revue de la littérature." Montpellier 1, 1991. http://www.theses.fr/1991MON11168.

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Rose, Christian. "Manifestations systemiques du p. O. E. M. S. Syndrome : a propos de 5 observations." Lille 2, 1994. http://www.theses.fr/1994LIL2M266.

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Messaadi, Nassir. "Association d'un syndrome poems, d'un syndrome de gougerot-sjogren et d'une thrombocytemie essentielle : a propos d'une observation." Lille 2, 1992. http://www.theses.fr/1992LIL2M121.

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Malkin, Julia Sandra Ailsa. "The unnoticed perspective : poems about life with Asperger syndrome." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/31846.

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Asperger syndrome (AS) is a form of autism, a condition which affects communication, imagination and social interaction abilities. As a person with AS, my perspectives on life and its meaning, relationships and the social world are different from those of other people. This project is designed to be twofold – firstly to provide insights into life with AS in a form of literature which people can relate to; and secondly to allow the AS person to be able to see their own condition reflected in an accessible form. This document is intended to be used by those with Asperger syndrome, their parents and families, and professionals who work with them. It reflects on autism in general, the triad of impairments from an Asperger perspective and complications resulting from this condition. It is also an exploration of the world of poetry, the use of form, a variety of metres which were popular at different times, and involving poetic challenges of expressing emotion and feeling. This work goes into themes such as relationships and friendships, sense of time and space, sensory difficulties, growing up as an AS person, obsessional behaviour patterns, communication problems and other AS issues. It is designed to raise awareness of the AS condition and provide support to those who have it, while at the same time being entertaining and accessible to the general population.

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Книги з теми "POEMS syndrom"

Leah, Maines, ed. There will be cats: Poems. Georgetown, Ky: Finishing Line Press, 2009.

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Lawson, Wendy. ASPoetry: Illustrated poems from an aspie life. London: Jessica Kingsley Publishers, 2006.

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Klein, Michael, 1954 Aug. 17- and McCann Richard, eds. Things shaped in passing: More "poets for life" writing from the AIDS pandemic. New York: Persea Books, 1997.

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Steensma, David P. Malignant Hematology. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199755691.003.0296.

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The hematologic neoplasms include lymphoproliferative disorders (eg, chronic lymphocytic leukemia [CLL]/small lymphocytic lymphoma [SLL], large granular lymphocyte leukemia, hairy cell leukemia [HCL], Hodgkin lymphoma, non-Hodgkin lymphoma), plasma cell disorders (multiple myeloma, light chain amyloidosis, Waldenström macroglobulinemia, POEMS syndrome, heavy chain disease, plasmacytoma), chronic myeloid neoplasms (chronic myeloid leukemia, the BCR/ABL-negative myeloproliferative neoplasms, myelodysplastic syndromes), and acute leukemia (acute myeloid leukemia, acute lymphocytic leukemia). In addition, clonal but not overtly malignant conditions are common in the general population, including monoclonal gammopathy of undetermined significance (MGUS) and monoclonal B lymphocytosis (MBL).

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Provan, Drew, Trevor Baglin, Inderjeet Dokal, and Johannes de Vos. Paraproteinaemias. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199683307.003.0008.

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Paraproteinaemias - Monoclonal gammopathy of undetermined significance (MGUS) - Asymptomatic multiple myeloma (‘smouldering’ myeloma) - Multiple myeloma - Variant forms of myeloma - Cryoglobulinaemia - POEMS syndrome (osteosclerotic myeloma) - Plasmacytoma - Waldenström macroglobulinaemia - Heavy chain disease - AL (1° systemic) amyloidosis

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Provan, Drew, Trevor Baglin, Inderjeet Dokal, Johannes de Vos, and Mammit Kaur. Paraproteinaemias. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199683307.003.0008_update_001.

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Attwood, Anthony, and Karen Rodman. Asperger Syndrome and Adults... Is Anyone Listening?: Essays and Poems by Spouses, Partners and Parents of Adults with Asperger Syndrome. Kingsley Publishers, Jessica, 2003.

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Lawson, Wendy. Aspoetry: Illustrated Poems from an Aspie Life. Jessica Kingsley Publishers, 2006.

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Asperger Syndrome and Adults ... Is Anyone Listening: Essays and Poems by Partners, Parents and Family Members of Adults With Asperger's Syndrome. Jessica Kingsley Publishers, 2003.

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Частини книг з теми "POEMS syndrom"

Schaller, Martin, and Christian A. Sander. "Retracted Chapter: POEMS-Syndrom." In Fortschritte der praktischen Dermatologie und Venerologie, 631. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-642-56437-6_109.

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Kuwabara, Satoshi, and Sonoko Misawa. "POEMS Syndrome." In Neuroimmunological Diseases, 203–10. Tokyo: Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-55594-0_12.

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Schwab, Manfred. "POEMS Syndrome." In Encyclopedia of Cancer, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27841-9_4652-2.

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Dispenzieri, Angela. "POEMS Syndrome." In Neoplastic Diseases of the Blood, 609–16. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64263-5_32.

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Ziogas, Dimitrios C., Angela Dispenzieri, and Evangelos Terpos. "POEMS Syndrome." In Hematologic Malignancies, 177–89. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-25586-6_10.

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Braun-Falco, Markus, Henry J. Mankin, Sharon L. Wenger, Markus Braun-Falco, Stephan DiSean Kendall, Gerard C. Blobe, Christoph K. Weber, et al. "POEMS Syndrome." In Encyclopedia of Molecular Mechanisms of Disease, 1673–74. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_1425.

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Leung, Anskar Y. H., and Edmond S. K. Ma. "POEMS Syndrome." In Haematology and the Asian Patient, 113–16. Boca Raton: CRC Press, 2024. http://dx.doi.org/10.1201/9781003325413-32.

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Dispenzieri, Angela. "POEMS Syndrome (Takatsuki Syndrome)." In Multiple Myeloma, 179–93. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8520-9_15.

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Dispenzieri, Angela. "POEMS Syndrome and Castleman’s Disease." In Biology and Management of Unusual Plasma Cell Dyscrasias, 41–69. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4419-6848-7_3.

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Cook, Gordon, and Montserrat Rovira. "Poems Syndrome and Disease Produced by Other Monoclonal IGs." In The EBMT Handbook, 757–61. Cham: Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-44080-9_83.

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Анотація:

AbstractPOEMS syndrome (acronym of: polyradiculoneuropathy, organomegaly, endocrinopathies, monoclonal protein and dermopathy/§skin) is a rare multisystemic disease due to an underlying plasma cell neoplasm. The pathogenesis of the syndrome is not well understood. Other names of the POEMS syndrome that are less frequently used are osteosclerotic myeloma, Takatsuki syndrome, or Crow-Fukase syndrome.

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Тези доповідей конференцій з теми "POEMS syndrom"

Nery, Julia Pio Fernandes, Rafael Elian Alvares, Taianne Fiore Schumann, Cintia Alvarenga Pereira Vieira, and Glaucia Lara Resende. "Poems syndrome: a case report." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.677.

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Introduction: Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes syndrome (POEMS) is a rare monoclonal disease with multisystemic presentation and therefore challenging diagnosis. The aim is to report a case of a rare hematological disease with unusual characteristic neurological manifestation. Case report: Male, 59-year-old, with a report of anesthesia and paresthesia in the feet that started in 2018. On examination, he presented tactile and painful hypoesthesia in a path innervated by L5 to S1, in addition to hypoactive Achilles tendon reflexes. Electroneuromyography showing moderate-grade diffuse distal symmetric axonal sensorimotor polyneuropathy. In 2021, erythematous lesions appeared on the arms and hyperchromic macules on the left leg. Biochemical tests were performed with the presence of a monoclonal peak of gammaglobulins with a predominance of Kappa chains. In 2022, he presented worsening of tactile, painful and palesthetic sensations in the lower limbs, with no conscious proprioception. POEMS diagnostic hypothesis questioned. The myelogram revealed the presence of 12.4% of plasmocytes and the bone marrow biopsy showed cellularity of 40% with the presence of three lineages with slightly hyperplastic erythroid series. Hemogram presented polyglobulia. Imaging propaedeutics showed hepatomegaly. Confirmatory findings of monoclonal gammopathy and peripheral polyneuropathy, in addition to minor findings of skin changes, hepatomegaly, and polyglobulia, confirmed the diagnosis of POEMS. Conclusion: Polyneuropathy is a neurological hallmark of the disease and, when associated with a detected monoclonal protein, should lead to evaluation for POEMS, among the differentials of paraproteinemias. Finally, early recognition is essential to enable adequate treatment, which helps to stop the progressive worsening of symptoms, especially the debilitating neurological ones.

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Landman, Avi, Freddy Alonso Escobar, Rupin Singh, Jorge Morales, and Fabian Rossi. "POEMS syndrome associated with vitiligo (P13-8.007)." In 2023 Annual Meeting Abstracts. Lippincott Williams & Wilkins, 2023. http://dx.doi.org/10.1212/wnl.0000000000201929.

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Coutant, F., Z. Tatar, P. Rouzaire, B. Evrard, A. Dosgilbert, O. Tournilhac, G. Le Guenno, R. Lemal, and M. Soubrier. "AB0035 Angiopoietins: the missing link in poems syndrome?" In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.3697.

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Nery, Julia Pio Fernandes, Aldrin Pedroza Martins, Rafael Elian Alvares, Cintia Alvarenga Pereira Vieira, and Glaucia Lara Resende. "Poems syndrome: report of a rare disease with often neurologic presentation." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.680.

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Introduction: Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes (POEMS) syndrome is a rare monoclonal lambda plasma cell disorder, with multisystem presentation leading to a challenging diagnosis. The aim is to report a case of a rare hematologic disease, with neurologic manifestation widely seen in daily practice. Case report: Male, 35-year-old, with a history of distal weakness of the lower limbs, symmetrical, subacute onset and progressive worsening, associated with ascending numbness, lower back pain and fatigue. Neurological examination showed motor deficit in extremities (plantar flexion and extension), hypoactive reflexes of lower limbs, in addition to distal sensory deficit (tactile and painful). Electroneuromyography confirmed axonal sensory-motor neuropathy in both lower limbs. Biochemical testing revealed a monoclonal gammaglobulin peak with a predominance of lambda chains and an elevated serum vascular endothelial growth factor (VEGF) concentration. Magnetic resonance imaging detected sclerotic lesions in vertebral bodies of thoracic and lumbar spine. Furthermore, patient also had mild pigmentary changes in the skin of the extremities of lower limbs and polycythemia. Accordingly with the evaluation was possible to make POEMS diagnosis and patient is currently in preparation for an autologous bone marrow transplant. Conclusion: Polineuropathy is a neurological hallmark of the disease and should lead to evaluation for POEMS, when associated with a monoclonal protein detected. Elevated serum VEGF can be a biomarker that supports the diagnosis. In summary, early recognition is essential, because enables adequate treatment, which contributes to stop progressive worsening of symptoms, especially debilitating neurologic ones.

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Queiroz, Rodrigo, Thiago Pinheiro, Lya Marques, Tairine Silva, and Caroline Braune. "Severe painful neuropathy as the presenting feature of POEMS syndrome (P13-8.012)." In 2023 Annual Meeting Abstracts. Lippincott Williams & Wilkins, 2023. http://dx.doi.org/10.1212/wnl.0000000000203923.

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Venus, Cameron, Nawaf Yassi, Belinda Cruse, Mark Dowling, Monique Youl, and Edrich Rodrigues. "3119 A case of rapidly progressive neuropathy from poems syndrome with undetectable paraprotein." In ANZAN Annual Scientific Meeting 2024 Abstracts, A39.1—A39. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/bmjno-2024-anzan.108.

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Da Silva Cremonese, Gabriela, and Ivânio Alves Pereira. "POEMS SYNDROME, ALTHOUGH RARE, PRESENTS A CONSTELLATION OF CLINICAL FINDINGS THAT ALLOWS ITS EARLY DIAGNOSIS." In Congresso Brasileiro de Reumatologia 2020. Sociedade Brasileira de Reumatologia, 2021. http://dx.doi.org/10.47660/cbr.2020.17459.

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Chandrashekaran, Satish, Angela Dispenzieri, and Cassie C. Kennedy. "Autologous Peripheral Blood Stem Cell Transplantation Leads To Improvement In Pulmonary Morbidity In Poems Syndrome." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3039.

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Bapaye, A., A. Bale, M. Borkar, J. Ansari, R. Yewale, B. Pawar, G. Wagholikar, et al. "Retrograde trans-gastric vacuum therapy for treatment of Post-POEM Boerhaave syndrome." In ESGE Days 2023. Georg Thieme Verlag KG, 2023. http://dx.doi.org/10.1055/s-0043-1765976.

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Звіти організацій з теми "POEMS syndrom"

Wang, Xiaoyue, Hui Lu, Zhihao Liang, Liang Wang, and Ji Ma. Ixazomib combined with autologous stem cell transplantation for POEMS syndrome: a case report and meta‑analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2022. http://dx.doi.org/10.37766/inplasy2022.7.0061.

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Анотація:

Review question / Objective: POEMS syndrome is a rare monoclonal plasma cell proliferation disorder. At present, there is no unified treatment for POEMS syndrome. Here, we describe one case with POEMS syndrome. And we made a metaanalysis to assess the efficacy of treatment strategies in recent ten years. Search strategy: We searched relevant articles in PubMed, Embase and MEDLINE database for the period up to July 2021.The search strategy included the keywords: POEMS, Therapy, Drug Therapy, Biological Therapy, Combined Modality Therapy, Hematopoietic Stem Cell Transplantation, Immunotherapy, Molecular Targeted Therapy, Chemoradiotherapy, Salvage Therapy, Controlled Clinical Trial, Randomized Controlled Trial et al. In addition, we checked all the references of eligible articles that our search retrieved to identify potentially eligible papers.

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