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Добірка наукової літератури з теми "PHSA"

Автор: Grafiati

Опубліковано: 8 вересня 2022

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Статті в журналах з теми "PHSA"

Eys, S., D. Schwartz, W. Wohlleben, and E. Schinko. "Three Thioesterases Are Involved in the Biosynthesis of Phosphinothricin Tripeptide in Streptomyces viridochromogenes Tü494." Antimicrobial Agents and Chemotherapy 52, no. 5 (February 19, 2008): 1686–96. http://dx.doi.org/10.1128/aac.01053-07.

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ABSTRACT Phosphinothricin tripeptide (PTT) is a peptide antibiotic produced by Streptomyces viridochromogenes Tü494, and it is synthesized by nonribosomal peptide synthetases. The PTT biosynthetic gene cluster contains three peptide synthetase genes: phsA, phsB, and phsC. Each of these peptide synthetases comprises only one module. In neither PhsB nor PhsC is a typical C-terminal thioesterase domain present. In contrast, a single thioesterase GXSXG motif has been identified in the N terminus of the first peptide synthetase, PhsA. In addition, two external thioesterase genes, theA and theB, are located within the PTT biosynthetic gene cluster. To analyze the thioesterase function as well as the assembly of the peptide synthetases within PTT biosynthesis, several mutants were generated and analyzed. A phsA deletion mutant (MphsA) was complemented with two different phsA constructs that were carrying mutations in the thioesterase motif. In one construct, the thioesterase motif comprising 45 amino acids of phsA were deleted. In the second construct, the conserved serine residue of the GXSXG motif was replaced by an alanine. In both cases, the complementation of MphsA did not restore PTT biosynthesis, revealing that the thioesterase motif in the N terminus of PhsA is required for PTT production. In contrast, TheA and TheB might have editing functions, as an interruption of the theA and theB genes led to reduced PTT production, whereas an overexpression of both genes in the wild type enhanced the PTT yield. The presence of an active single thioesterase motif in the N terminus of PhsA points to a novel mechanism of product release.

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Schwartz, Dirk, Nicolas Grammel, Eva Heinzelmann, Ullrich Keller, and Wolfgang Wohlleben. "Phosphinothricin Tripeptide Synthetases in Streptomyces viridochromogenes Tü494." Antimicrobial Agents and Chemotherapy 49, no. 11 (November 2005): 4598–607. http://dx.doi.org/10.1128/aac.49.11.4598-4607.2005.

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ABSTRACT The tripeptide backbone of phosphinothricin (PT) tripeptide (PTT), a compound with herbicidal activity from Streptomyces viridochromogenes, is assembled by three stand-alone peptide synthetase modules. The enzyme PhsA (66 kDa) recruits the PT-precursor N-acetyl-demethylphosphinothricin (N-Ac-DMPT), whereas the two alanine residues of PTT are assembled by the enzymes PhsB and PhsC (129 and 119 kDa, respectively). During or after assembly, the N-Ac-DMPT residue in the peptide is converted to PT by methylation and deacetylation. Both phsB and phsC appear to be cotranscribed together with two other genes from a single promoter and they are located at a distance of 20 kb from the gene phsA, encoding PhsA, in the PTT biosynthesis gene cluster of S. viridochromogenes. PhsB and PhsC represent single nonribosomal peptide synthetase elongation modules lacking a thioesterase domain. Gene inactivations, genetic complementations, determinations of substrate specificity of the heterologously produced proteins, and comparison of PhsC sequence with the amino terminus of the alanine-activating nonribosomal peptide synthetase PTTSII from S. viridochromogenes confirmed the role of the two genes in the bialanylation of Ac-DMPT. The lack of an integral thioesterase domain in the PTT assembly system points to product release possibly involving two type II thioesterase genes (the1 and the2) located in the PTT gene cluster alone or in conjunction with an as yet unknown mechanism of product release.

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Teimoori, Shahnaz, Amir Hessam Hassani *©, and Mostafaa Panaahie. "the Extraction and determination of benzene from waters and wastewater samples based on functionalized carbon nanotubes by static head space gas chromatography mass spectrometry." Analytical Methods in Environmental Chemistry Journal 3, no. 01 (March 26, 2020): 17–26. http://dx.doi.org/10.24200/amecj.v3.i01.91.

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In this study, the phenyl sulfonic acid (PhSA) modified carbon nanotubes (CNTs) were used for benzene removal from waters by (D- μSPE). Due to adsorption mechanism, π–π interactions was provided between the aromatic ring of benzene with the surface (SO3H) and phenyl ring (-C6H5) of CNTs, respectively. Therefore, 20-100 mg of sorbent, concentration of benzene (0.1–10 mg L-1), pH (1-12) and contact time (5–120 min) were investigated and optimized for benzene removal from water samples in static system. The concentration of benzene in water was determined by (SHS-GC-MS). The results showed, the Langmuir-Freundlich (LF) isotherm provided the best fit for benzene sorption. By using the Langmuir model, the maximum adsorption capacity of 117.34 and 22.86 mg/g was achieved for benzene removal from waters with CNTs@PhSA and CNTs, respectively. Under optimal conditions, adsorption efficiency of CNTs@PhSA and CNTs was obtained 97.7% and 20.6 % for benzene removal from water samples, respectively.

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Calegaro, Vítor Crestani, Cleonice Zatti, Andre Goettems Bastos, and Lucia Helena Machado Freitas. "Suicidal patients in a psychiatric emergency unit: clinical characteristics and aggression profile." Trends in Psychiatry and Psychotherapy 41, no. 1 (March 2019): 9–17. http://dx.doi.org/10.1590/2237-6089-2017-0149.

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Abstract Objective To explore and describe a profile of patients admitted to a psychiatric emergency facility, comparing patients with and without a recent suicide attempt in terms of their clinical characteristics and aggression. Methods This was an exploratory comparative study where patients were assessed using the Brief Psychiatric Rating Scale (BPRS) and the Overt Aggression Scale (OAS). Participants with a suicide attempt in the last 24 hours (SA) were compared to participants with a prior history of suicide attempt but no recent attempt (PHSA). Results 63 individuals (SA: 26; PHSA: 37) were selected. Both groups had similar demographic and clinical characteristics. The most prevalent diagnoses were mood (57.1%) and personality (50.8%) disorders. The majority of patients in both groups had a history of aggression episodes. Physical aggression in the week prior to admission was more prevalent in the PHSA group (51.4 vs. 19.2%, p = 0.017). The PHSA group also presented higher activation scores (p = 0.025), while the SA group presented higher affect scores on BPRS dimensions (p = 0.002). Conclusion The majority of individuals with a history of suicide attempt also presented a history of aggression. Inpatients with recent suicide attempt were hospitalized mainly due to the risk of suicide, while those with no recent suicide attempt were hospitalized mainly due to the risk of hetero-aggression. These findings support the hypothesis of an aggressive profile in suicidal patients and may open up a path for future research.

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Sansonno, Domenico E., Paolo Detomaso, Giuseppe Leone, Gaetano Bufano, Rocco Rizzi, and Onofrio G. Manghisi. "Antibodies to glutaraldehyde-polymerized human albumin (anti-pHSA) in viral hepatitis." Digestive Diseases and Sciences 34, no. 9 (September 1989): 1443–48. http://dx.doi.org/10.1007/bf01538083.

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Hutchinson, Ryan C., Kevin J. Wu, John C. Cheville, and David D. Thiel. "Prostatic Stromal Hyperplasia with Atypia." Case Reports in Urology 2013 (2013): 1–2. http://dx.doi.org/10.1155/2013/364124.

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Prostatic stromal hyperplasia with atypia (PSHA) is a rare histologic finding diagnosed incidentally on prostate biopsies, transurethral resection specimens, and radical prostatectomy specimens. PSHA has a bizarre histologic appearance and these lesions often raise concern for sarcoma; however, their clinical course is indolent and does not include extraprostatic progression. We discuss a case of PHSA discovered on prostate biopsy performed for an abnormal digital rectal examination and review the literature on this rare pathologic finding.

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Giacomelli, Fernando Carlos, Fabiano Vargas Pereira, Abdellatif Moussaid, and Nádya Pesce da Silveira. "Dynamic behavior of PMMA-PHSA hard spheres suspensions under external electric field." Macromolecular Symposia 245-246, no. 1 (December 2006): 457–62. http://dx.doi.org/10.1002/masy.200651365.

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Hsieh, C. J., and G. H. Jones. "Nucleotide sequence, transcriptional analysis, and glucose regulation of the phenoxazinone synthase gene (phsA) from Streptomyces antibioticus." Journal of bacteriology 177, no. 20 (1995): 5740–47. http://dx.doi.org/10.1128/jb.177.20.5740-5747.1995.

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Chavan, Sayali Ramdas, Patrick Perré, Victor Pozzobon, and Julien Lemaire. "CO2 Absorption Using Hollow Fiber Membrane Contactors: Introducing pH Swing Absorption (pHSA) to Overcome Purity Limitation." Membranes 11, no. 7 (June 30, 2021): 496. http://dx.doi.org/10.3390/membranes11070496.

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Recently, membrane contactors have gained more popularity in the field of CO2 removal; however, achieving high purity and competitive recovery for poor soluble gas (H2, N2, or CH4) remains elusive. Hence, a novel process for CO2 removal from a mixture of gases using hollow fiber membrane contactors is investigated theoretically and experimentally. A theoretical model is constructed to show that the dissolved residual CO2 hinders the capacity of the absorbent when it is regenerated. This model, backed up by experimental investigation, proves that achieving a purity > 99% without consuming excessive chemicals or energy remains challenging in a closed-loop system. As a solution, a novel strategy is proposed: the pH Swing Absorption which consists of manipulating the acido–basic equilibrium of CO2 in the absorption and desorption stages by injecting moderate acid and base amount. It aims at decreasing CO2 residual content in the regenerated absorbent, by converting CO2 into its ionic counterparts (HCO3− or CO32−) before absorption and improving CO2 degassing before desorption. Therefore, this strategy unlocks the theoretical limitation due to equilibrium with CO2 residual content in the absorbent and increases considerably the maximum achievable purity. Results also show the dependency of the performance on operating conditions such as total gas pressure and liquid flowrate. For N2/CO2 mixture, this process achieved a nitrogen purity of 99.97% with a N2 recovery rate of 94.13%. Similarly, for H2/CO2 mixture, a maximum H2 purity of 99.96% and recovery rate of 93.96% was obtained using this process. Moreover, the proposed patented process could potentially reduce energy or chemicals consumption.

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Wei, Wei, Su-fei Wang, Bing Yu, and Ming Ni. "Inhibition of HBV replication by delivering the dual-gene expression vector pHsa-miR16-siRNA in HepG2.2.15 cells." Current Medical Science 37, no. 6 (December 2017): 828–32. http://dx.doi.org/10.1007/s11596-017-1810-0.

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Більше джерел

Дисертації з теми "PHSA"

Chavan, Sayali Ramdas. "Development, modeling and optimization of CO2 separation process using membrane contactor : applied to hydrogen purification." Thesis, université Paris-Saclay, 2022. http://www.theses.fr/2022UPAST040.

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Ce travail est consacré à la séparation du CO2 d'un syngas pour produire de l'hydrogène de haute pureté par contacteurs membranaires. Le pilote construit au laboratoire utilise des contacteurs à fibres creuses (HFMC). Un premier jeu de données montre que la pureté reste sous le seuil de 99%. Un modèle théorique d'équilibre a permis d'expliquer cela par les concentrations résiduelles de carbonate CO2/3− et de bicarbonate HCO3−. Cela a permis de proposer une nouvelle approche reposant sur la variation du pH (pHSA). Elle atteint une pureté de H2 de 99,96 % et un rendement de 94 %. Un modèle prédictif de transferts a été résolu en 1D, pour une absorption de CO2 pur puis pour un mélange gazeux. Dans les deux cas, les paramètres ont été ajustés puis validés sur des données expérimentales. Ce travail ouvre des perspectives pour une solution compétitive en coûts d'investissement et d'exploitation. Le modèle numérique développé est un puissant outil de conception et d'optimisation
This work focuses on separating CO2 from syngas to produce high purity hydrogen based on gas-liquid absorption. To do so, a lab-scale pilot was built featuring three Hollow Fiber Membrane Contactors (HFMC). Primary sensitivity analysis of the process revealed that the purity remains below 99%, explained by the residual concentrations of carbonate CO2/3− and bicarbonate HCO3−. A theoretical equilibrium model and later a new approach based on pH variation (pHSA) was put forward to overcome the purity limitation achieving H2 purity of 99.96% and 94% yield. Moreover, a predictive transfer model was solved in 1D to predict absorption of CO2 in pure and gas mixtures. The model was fitted for both cases and then validated with experimental data. This work opens perspectives as a competitive solution in terms of investment and operating costs. The numerical model developed is a powerful design and optimization tool

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Reese, Michele. "Following Phia /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9998505.

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Henriques, Rita da Silveira. "Perturbação de hiperactividade com défice de atenção." Master's thesis, Universidade da Beira Interior, 2011. http://hdl.handle.net/10400.6/945.

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Introdução: A Perturbação de Hiperactividade com Défice de Atenção (PHDA) é um dos distúrbios comportamentais mais frequentes em crianças em idade escolar, tendo apresentado um aumento significativo da sua taxa de prevalência na última década. Afecta de forma significativa o rendimento da criança em vários domínios da sua vida quotidiana, sendo frequentemente acompanhada por uma série de comorbilidades, que influenciam de forma negativa o prognóstico desta patologia. Os défices psicomotores encontrados em grande parte destas crianças, estão associados, em muitos casos, a dificuldades de aprendizagem que se revelam de forma marcante no meio escolar. Objectivos: Este estudo pretende caracterizar a população de crianças com PHDA seguidas no Serviço de Pedopsiquiatria do Centro Hospitalar Cova da Beira (CHCB), na valência de psicomotricidade, bem como identificar o seu perfil psicomotor. Pretende-se, ainda, reconhecer as alterações mais frequentes ao nível dos diferentes factores psicomotores avaliados na Bateria Psicomotora (BPM) de Vítor da Fonseca e verificar a influência da terapia psicomotora na evolução desses défices. Materiais e Métodos: Foram recolhidos os dados referentes à aplicação da BPM em 41 crianças, com idades compreendidas entre os 6 e os 12 anos de idade, com o diagnóstico clínico de PHDA, sendo que 21 dessas crianças foram sujeitas a terapia psicomotora e a uma segunda avaliação através da BPM. Foram analisados os dados correspondentes aos dois períodos de avaliação. Resultados: Os resultados mostraram que embora a maioria das crianças avaliadas apresente um perfil psicomotor normal ou bom, existem alguns défices particulares quando são analisados separadamente os diferentes factores psicomotores, tal como se pode verificar no caso da equilibração, estruturação espácio-temporal e praxia global. Por outro lado, existe uma relação significativa entre a idade, a fase de aprendizagem (ano de escolaridade) da criança e os resultados obtidos na BPM. A terapia psicomotora esteve associada a melhorias significativas no perfil psicomotor. Conclusão: De um modo geral, este estudo apoia a aplicação da BPM no estudo dos défices psicomotores em crianças com dificuldades de aprendizagem e PHDA. A evolução verificada após intervenção psicomotora, quer nas pontuações totais, quer nalguns factores psicomotores em particular, serve de suporte ao seu uso terapêutico neste tipo de crianças.
Introduction: Attention–deficit/hyperactivity disorder (ADHD) is one of the most common behavioural disorders in school age children. We verified a significant increase of the prevalence rate in the last decade. ADHD has many comorbidities affecting the life of the child in every domain with a negative influence in the prognosis of this condition. Psychomotor deficits are responsible for many of the learning disabilities of these children. Goals: This study pretends to characterize the population of children with ADHD followed in the Department of Child Psychiatry of the Centro Hospitalar Cova da Beira (CHCB), under psychomotor therapy. We also pretend to identify the most frequent changes on the different factors evaluated by Psychomotor Battery (BPM) of Vítor da Fonseca and the influence of psychomotor therapy. Materials and Methods: We applied BPM in a sample of 41 children aged between 6 and 12 years old, with the diagnosis of ADHD. 21 of these children were on psychomotor therapy. The data was collected at baseline and at the end of the intervention. Results: The results showed that most of the children had a normal or good psychomotor profile. However there are some impairments when analysing the psychomotor factors one by one. There is a relationship between age, stage of learning (school year) and the results in BPM. Psychomotor profile had a significant improvement after psychomotor therapy. Conclusion: Overall, this study supports the use of BPM in the evaluation of psychomotor deficits in children with learning disabilities and ADHD. The improvements seen after psychomotor intervention, both in global scores or in some factors in particular, support its therapeutic use in such children.

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Johnson, Emma Caroline. "Characterisation of PHYA mutants of Arabidopsis thaliana." Thesis, University of Leicester, 1995. http://hdl.handle.net/2381/35317.

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Phytochrome, a R/FR reversible photoreceptor that regulates plant photomorphogenesis, is encoded by a gene family of which there are at least five members. The best characterised member is phytochrome A which accumulates to high levels in etiolated tissue but is degraded in light, unlike other members of the family which are light-stable. A two-stage screen was designed for isolation of phyA mutant seedlings. The mutant phenotype was illustrated by deficiency in FR-HIR-mediated inhibition of hypocotyl elongation, which is exclusively mediated by phytochrome A while retaining R-HIR-mediated inhibition of hypocotyl elongation, which is mediated by one or more of the light-stable phytochrome species. Mutants isolated using this screen were divided into three complementation classes, fhy1, fhy2 and fhy3. Immunoblot and spectrophotometric analyses of these three mutant lines demonstrated that one of them, fhy2, was deficient in phytochrome A protein. Southern analysis of several alleles of the fhy2 mutation indicated that deficiency in phytochrome A resulted from structural alterations in the PHYA gene. Subsequently, the fhy2 mutants were designated as phyA mutants. The other two classes of long hypocotyl mutants isolated in this screen, fhy1 and fhy3, showed no structural alteration in the PHYA gene and had normal immunochemically and spectrophotometrically detectable levels of phytochrome A. Therefore, fhy1 and fhy3 are putative transduction chain mutants. Comparison of the photophysiology of phytochrome A mutants with that of wild-type seedlings allowed conclusions to be drawn about the roles of phytochrome A in selected, assayable photomorphogenetic responses. phyA mutant seeds exhibit wild-type germination responses to R but do not germinate in FR, suggesting that phytochrome A mediates a promotory response to FR. The importance of phytochrome A as the principal photoreceptor in FR is extended to de-etiolated plants where phytochrome A retains an inhibitory role in hypocotyl elongation, under supplementary FR or low R:FR ratio conditions. Phytochrome A also plays a role in flowering which becomes apparent under low fluence-rate incandescent day extensions, suggesting that in fluence-rate limiting conditions, phytochrome A is an important component of daylength perception. fhy1 and fhy3 mutants, selected for long hypocotyls in FR alongside phyA mutants, were also characterised and shown to have wild-type levels of phytochrome A protein with no apparent rearrangement of the PHYA gene. The mutation at FHY1 affects hypocotyl elongation but not germination, de-etiolation or flowering, suggesting that hypocotyl elongation is on a different branch of the transduction chain to these other responses and that FHY1 is a component of that branch. Hypocotyl elongation of fhy3 seedlings is affected in R, as well as in FR which may suggest that the transduction chain component encoded by FHY3 is shared by the phytochrome, or phytochromes, that control hypocotyl elongation in R. Characterisation of phyA and fhy mutants of Arabidopsis has led to elucidation of the roles of phytochrome A in different photomorphogenetic responses and some preliminary investigation of components of the transduction chain. This reseach has also further clarified the roles of other phytochromes and the extent of overlap of the spheres of action of distinct molecular species of phytochrome.

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Guerrouani, Nadia. "Synthèse de copolymères amphiphiles triblocs PHA-b-PEG-b-PHA et greffés PVA-g-PHA : Modification de surface de films par plasma." Montpellier 2, 2005. http://www.theses.fr/2005MON20198.

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Skřivanová, Veronika. "Metody identifikace PHA produkujících bakterií." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2016. http://www.nusl.cz/ntk/nusl-240529.

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This diploma thesis deals with testing, optimazing and comparing methods for the identification of bacteria producing polyhydroxyalkanoates. Work included cultivation and microscopy methods, wherein the bacterial cells were stained with lipophilic dyes Nile red and Sudan black. Further, we also used flow cytometry and spectroscopic methods - Raman spectroscopy and infrared spectroscopy with Fourier transformation, and molecular biological methods, which analyzed the presence of a gene encoding PHA synthase (phaC) by polymerase chain reaction (PCR). PCR assay consist of two reactions, the firt on eis based on amplification of phaC gene along with 16S rRNDA gene, which is common for all the bacteria (multiplex PCR). The second reaction is focused on specific amplification of PHA synthase catalyzing biosynthesis of mcl-PHA. In order to overcome false positive results typical for methods analyzing genotype and also to avoid false negative results occuring in fenotype analyzing methods, the best strategy is to combine both aproaches. According to our results, analysis of presence of phaC gene by PCR can be combined with methods capable of determining presence of PHA in bacterial cells. For this purpose, Raman microspectroscopy seems to be very promising tool, since it is able to detect low content of PHA in cells and PHA can not be confused with other lipid metabolites. The results provide an overview of test methods, their advantages and disadvantages and also to compare different criteria according to which it is possible to choose the method of identification in depending on the adjustable requirements.

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Seeger, Martin. "Phra Dhammapiṭaka und die Pāli-Kanon-Debatte in Thailand ein Beitrag zur Untersuchung des modernen Buddhismus /." [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974091227.

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Ravelli, Thandara Garcia. "Seleção de genes codificadores de PHA sintases para a construção de recombinantes em Burkholderia sacchari e Pseudomonas sp e avaliação da produção de polihidroxialcanoatos com diferentes composições monoméricas." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42132/tde-11062015-103546/.

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Polihidroxialcanoatos (PHA) são poliésteres acumulados por diversas bactérias a partir de fontes renováveis e são termoplásticos, biodegradáveis e biocompatíveis. A variabilidade da composição monomérica de PHA determina suas propriedades mecânicas e permite seu uso em diversas aplicações. A PHA sintase é a enzima responsável pela polimerização do PHA. O objetivo deste trabalho foi à busca por genes codificadores desta enzima, construção e avaliação de recombinantes portando tais genes. Inicialmente buscaram-se novos genes de PHA sintase a partir de clones de uma biblioteca metagenômica previamente detectados por PCR como positivos para algum tipo de PHA sintase. Posteriormente buscou-se PHA sintases de classe III e construiram-se recombinantes de Pseudomonas sp e B. sacchari pela introdução de genes de C. vinosum (phaECCv). Nas duas recombinantes, os genes inseridos foram capazes de aumentar a fração de 3HHx em relação a linhagem selvagem, quando se utilizou glicose e hexanoato como fontes de carbono.
Polyhydroxyalkanoates (PHA) are polyesters accumulated from renewable sources by several bacteria and are thermoplastic, biodegradable and biocompatible. The variability of the PHA monomer composition determines its mechanical properties and allows their use in many applications. PHA synthase is the enzyme responsible for the polymerization of PHA. The objective was to search for genes encoding this enzyme, construction and the assessment of recombinant bacteria carrying such genes. Initially a screening of PHA synthase genes was made from a metagenomic library clones previously identified as positive by PCR for any type of PHA synthase. Later a search for class III PHA synthases was made as a construction of a recombinant Pseudomonas sp and B. sacchari by introducing genes of C. vinosum (phaECCv). In the two recombinant strains, the genes inserted were able to increase the fraction of 3HHx compared to the wild strain when glucose and hexanoate was used as carbon sources.

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Klamsom, Prānī. "Kānkǣ panhā sētthakit thī kīeokap chāonā dōi withī kānsahakō̜n nai ratchasamai Phrabāt Somdet Phra Mongkutklao Čhaoyūhūa læ Phrabāt Somdet Phra Pokklao Čhaoyūhūa." Google Book Search Library Project, 1986. http://books.google.com/books?id=HUtXAAAAMAAJ.

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Thesis (M.A.)--Chulalongkorn University, 1986.
In Thai; abstract also in English. Added t.p.: Cooperative measures in solving economic problems related to peasants during the reigns of King Rama VI and King Rama VII. Includes bibliographical references (leaves 116-126). Also issued in print.

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Brunetti, Lucia. "Electrospinning of PHAs composites filled with bioactive glass particles." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/17525/.

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The use of composite materials, especially for the development of scaffolds, is having a great impact in the biomedical field. Every day thousands of surgical procedures are performed to replace or repair tissue that has been damaged through disease or trauma. The developing field of tissue engineering (TE) aims to regenerate damaged tissues by combining cells from the body with highly porous biomaterials scaffold, which act as templates for tissue regeneration, to guide the growth of new tissue. Consequently, there are a lot of researches focused on the development of new materials that must fulfill mandatory requirements such as biocompatibility, biodegradability, bioresorbability and adequate mechanical features. Scaffolds play a key role in the field of TE, thus they provide a healthy environment for cells attachment, differentiation, proliferation, and migration. Therefore, according to the native tissue, the mechanical and physiological characteristics of the biomaterials used for scaffolding are expected to be similar. In this work, electrospun fibers will be realized by investigating an innovative composition of the homopolymer Poly(3-hydroxybutyrate) (PHB) and the copolymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) for what regards the polymeric matrix, and the latter will be filled with bioactive glasses, in order to realize a composite material suitable for biomedical applications.

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Книги з теми "PHSA"

Phesa ṭū phesa. Dillī: Yaśa Pablikeśaṃsa, 2011.

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Ñāṇasampanno, Boowa. Phra čhing, phra plō̜m. Udon Thani, Thailand]: [Wat Pā Bān Tāt], 2004.

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Lūangphasī, Dūangsai. Tamnān Phra Kǣomō̜rakot: Phra Manīrattanapathimākō̜n Kǣomō̜rakot, Phra Kǣo khīeo, lư̄ Phra Phutthaphō̜nmanī, læ lư̄ Phra Rattanaphimphūang. 2nd ed. [Vientiane]: Nyāmǣ Khāo Khamtan Lūangphasī, 1997.

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Boonkong, Supharoek. Phra Abhaimani. Pathumthani, Thailand: Published and distributed by Skybook, 2005.

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Ñāṇasampanno, Boowa. Phra ʻō̜rahan. [Udon Thani: Wat Pā Bān Tāt], 2009.

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Sivaraksa, Sulak. Phra Trīpidok. 2nd ed. Krung Thēp: Sūn Thai Thibēt, 2013.

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Naphīsīphisānkhun, Phra. Phra Naphīsīphisānkhun. Chiang Mai, Thailand: Khana Sityānusit, 2005.

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Phū, Sunthō̜n. Phra ʻAphaimanī. 2-ге вид. Krung Thēp: Samnakphim Phetkarat, 2011.

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Phū, Sunthō̜n. Phra Aphaimani. [Bangkok]: Office of the National Culture Commission, Ministry of Education, Thailand, 1999.

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Pannapadipo, Phra. Phra farang. London: Arrow, 2005.

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Частини книг з теми "PHSA"

Paupp, Terrence E. "The Future of World Order and the “Principle of Hegemonic State Accountability” (PHSA)." In The Future of Global Relations, 193–211. New York: Palgrave Macmillan US, 2009. http://dx.doi.org/10.1057/9780230622692_12.

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Grabowsky, Volker. "Phra Lo." In Kindlers Literatur Lexikon (KLL), 1–2. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_16174-1.

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Braun-Falco, Markus, Henry J. Mankin, Sharon L. Wenger, Markus Braun-Falco, Stephan DiSean Kendall, Gerard C. Blobe, Christoph K. Weber, et al. "PHA-1." In Encyclopedia of Molecular Mechanisms of Disease, 1633. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8085.

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Quail, Peter H., Wesley B. Bruce, Katayoon Dehesh, and Jacqueline Dulson. "phyA Gene Promoter Analysis." In Plant Molecular Biology 2, 499–508. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-3304-7_48.

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Takagawa, Yuichiro. "The PHS Standard." In Cordless Telecommunications Worldwide, 429–38. London: Springer London, 1997. http://dx.doi.org/10.1007/978-1-4471-0913-6_23.

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Olivera, Elías R., Mario Arcos, Germán Naharro, and José M. Luengo. "Unusual PHA Biosynthesis." In Microbiology Monographs, 133–86. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-03287-5_7.

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Poltronieri, Palmiro, and Prasun Kumar. "Polyhydroxyalkanoates (PHAs) in Industrial Applications." In Handbook of Ecomaterials, 2843–72. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-68255-6_70.

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Poltronieri, Palmiro, and Prasun Kumar. "Polyhydroxyalcanoates (PHAs) in Industrial Applications." In Handbook of Ecomaterials, 1–30. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-48281-1_70-1.

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Poltronieri, Palmiro, and Prasun Kumar. "Polyhydroxyalkanoates (PHAs) in Industrial Applications." In Handbook of Ecomaterials, 1–30. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-48281-1_70-2.

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Walke, Bernhard. "Personal Handyphone System (PHS)." In Mobilfunknetze und ihre Protokolle, 245–79. Wiesbaden: Vieweg+Teubner Verlag, 2000. http://dx.doi.org/10.1007/978-3-322-92666-1_7.

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Тези доповідей конференцій з теми "PHSA"

Qin, Haiyan, Yonglong Zhang, and Bin Li. "pHSA: A Price Schedule for Heterogeneous Spectrum Auction." In 2016 IEEE Trustcom/BigDataSE/ISPA. IEEE, 2016. http://dx.doi.org/10.1109/trustcom.2016.0323.

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Urra, Susan. "Evolution of Process Hazard Analysis in an Oil and Gas Pipeline Company: From Ad-Hoc to an Enterprise Standard Practice." In 2012 9th International Pipeline Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/ipc2012-90302.

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Enbridge’s decision to formalize a Process Hazard Analysis (PHA) program has taken the organization through a journey from an informal/ad hoc practice to a rigorous, standardized, best-practice-based process with selected methodologies and tools being applied to all capital and operation projects in the company. This paper begins with a description of past hazard practices in the oil and gas pipeline industry in relation to the application of a hazard analysis. The oil and gas pipeline industry is governed by PHMSA, NEB, TSB, and provincial OHSA regulations, but is not regulated by OSHA or EPA RMP. Using this regulatory framework as a reference, a standard corporate PHA at Enbridge was developed and implemented. The paper describes the process, the methodologies, and the associated templates and tools. The implementation strategy is also discussed, including training deployment and communication plans. Finally, a road map for continuous improvement describes how to make the process sustainable by closing the current process gaps in relation to best practices and achieving a maturity stage of execution.

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Felner, Ariel, Roni Stern, and Sarit Kraus. "PHA*." In the first international joint conference. New York, New York, USA: ACM Press, 2002. http://dx.doi.org/10.1145/544741.544800.

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Yu, Shangxian, Xiao Tong, Weijian Zhao, Xinhua Jin, and Jiangnan Gu. "PHSF-HASN series photothermoresists." In Microlithography 2000, edited by Francis M. Houlihan. SPIE, 2000. http://dx.doi.org/10.1117/12.388338.

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Kostkova, Patty, Daniela Paolotti, and John Brownstein. "Session details: PHDA'13 workshop." In WWW '13: 22nd International World Wide Web Conference. New York, NY, USA: ACM, 2013. http://dx.doi.org/10.1145/3254946.

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Ooe, Yasuhiko, Kentaro Yamasaki, and Tsukasa Noma. "PWS & PHA." In the the 1st ACM workshop. New York, New York, USA: ACM Press, 2004. http://dx.doi.org/10.1145/1026653.1026669.

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Liao, W. A., and D. R. Siems. "Adsorption Characteristics of PHPA on Formation Solids." In IADC/SPE Drilling Conference. Society of Petroleum Engineers, 1990. http://dx.doi.org/10.2118/19945-ms.

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Benson, C. M., P. G. Holborn, A. M. Rolt, J. M. Ingram, and E. Alexander. "Combined Hazard Analyses to Explore the Impact of Liquid Hydrogen Fuel on the Civil Aviation Industry." In ASME Turbo Expo 2020: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/gt2020-14977.

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Abstract Interest in green technology in aviation is increasing. To address environmental issues, novel fuels such as cryogenic liquid hydrogen (LH2) are being explored, however there are safety concerns. This work combines safety studies to explore LH2 fuel safety for civil aviation. Preliminary hazard analyses (PHAs) (utilizing over 70 standards and guides) have been performed identifying possible LH2 hazards on-board aircraft. A PHA has also been produced, with industry stakeholder involvement, to understand the major concerns for LH2 use at airports. Gaps in fundamental knowledge and LH2 technology have been identified, and two of these explored. Firstly, work has been started to understand the fundamental flammability of hydrogen in altitude conditions. Secondly, FLACS CFD modelling has been used to simulate large-scale LH2 pool releases to examine behavior and predict pool size, downwind flammable regions, and flammable mass clouds formed for different environmental conditions and release scenarios. This has identified significant effects of wind speed on buoyancy and flammable cloud travel which must be taken into account of any hydrogen fuel facility design. This work (part of the EC funded ENABLEH2 project) is some of the first in over a decade to re-examine the safety of hydrogen propulsion in aircraft. This process has identified wide-ranging issues that must be addressed before hydrogen propulsion can be introduced in civil aviation.

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Hansen, Bruce, Skip Brown, and David Kuhtenia. "Update on Hazardous Liquid Integrity Management Inspections for US Operators." In 2006 International Pipeline Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/ipc2006-10607.

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The US Department of Transportation’s Pipeline Hazardous Materials Safety Administration (PHMSA) started the second round of integrity management inspections on hazardous liquid pipeline operators in mid-2005. Since then PHMSA has used the information gained from all of the Hazardous Liquid Integrity Management (HL IM) inspections to continue the development of the HL IM inspection process. In 2000 and 2002, the US Department of Transportation’s Office of Pipeline Safety (OPS) published new regulations requiring integrity management programs for hazardous liquid pipeline operators. The fundamental objectives for HL IM have not changed: 1) to increase the level of integrity assessments (i.e., in-line inspection or pressure testing) for pipelines that can affect high consequence areas; 2) to improve operator integrity management systems; 3) to improve government oversight of operator integrity management programs; and 4) to improve public assurance in pipeline safety. The IM rule is based on a set of management-based requirements (referred to as “Program Elements” in the rule) that are fundamentally different from the previously existing, largely prescriptive pipeline safety requirements. The evaluation of operator compliance with these requirements requires the inspection of management and analytical processes - aspects of operator’s business that are not reviewed in standard PHMSA compliance inspections. PHMSA has gained significant experience with the fundamentally different approach to oversight needed to assure operators are developing and implementing effective integrity management programs. This paper describes the lessons learned from the inspections themselves and from basic changes in the management of the HL IM inspection program. PHMSA completed the initial integrity management inspection of all large hazardous liquid pipeline operators in 2004 and has continued inspecting both small system IM operators and re-inspecting large operators. As of December 2005 PHMSA has completed the inspection of 175 first round interstate hazardous liquid pipeline operators of which 101 are interstate systems and 74 are programs of intrastate hazardous liquid operators. Additionally, 14 second round inspections of hazardous liquid operators have been performed. Since the initial pilot hazardous liquid integrity management (HL IM) inspections in 2002 PHMSA has found that operators generally understand what portions of their pipeline systems can affect high consequence areas, and have made significant progress in conducting integrity assessments for these areas (Figure 1). However, the development of effective management and analytical processes, and quality data and information to support these processes still requires considerable attention from some operators. While most operators appear to be headed in the right direction, fundamental changes to management systems require time and management commitment. PHMSA recognizes this situation and continues to develop and implement an inspection and enforcement approach that seeks to assure compliance with the rule requirements and continuous improvement in operator integrity management programs. Finally, after several years of integrity management development and associated inspections PHMSA gained additional experience about how to perform this new type of inspection. An important change in the program took place in late 2004 when the PHMSA regions took over the scheduling, inspection program, and other aspects of managing the IM inspections. This paper also addresses what PHMSA learned about its inspection program, and how this program is being positioned by the regions to support on-going inspections of hazardous liquid operator integrity management programs.

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Mayberry, Alan K. "Pipeline Infrastructure Growth Challenges." In 2010 8th International Pipeline Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/ipc2010-31605.

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The rapid and unprecedented recent pipeline construction boom to satisfy energy demand has successfully delivered needed energy supplies to growing markets. In the United States, inspectors from the Pipeline and Hazardous Materials Safety Administration (PHMSA) significantly increased their inspection focus to cover many projects over the last four years. The results of many inspections were the subject of a PHMSA public meeting in April 2009, along with at least one Advisory Bulletin. This paper describes key issues PHMSA has witnessed, addressed, and taken action. The paper will also provide guidance on where industry should focus quality improvement initiatives.

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Bange, Marilyn S. 9 Combined PHSs. Office of Scientific and Technical Information (OSTI), September 2018. http://dx.doi.org/10.2172/1475508.

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Bange, Marilyn S. PHS Neutron Generator Monitor Laboratory. Office of Scientific and Technical Information (OSTI), October 2018. http://dx.doi.org/10.2172/1481625.

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Wideman, Jr., Robert F., Nicholas B. Anthony, Avigdor Cahaner, Alan Shlosberg, Michel Bellaiche, and William B. Roush. Integrated Approach to Evaluating Inherited Predictors of Resistance to Pulmonary Hypertension Syndrome (Ascites) in Fast Growing Broiler Chickens. United States Department of Agriculture, December 2000. http://dx.doi.org/10.32747/2000.7575287.bard.

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Background PHS (pulmonary hypertension syndrome, ascites syndrome) is a serious cause of loss in the broiler industry, and is a prime example of an undesirable side effect of successful genetic development that may be deleteriously manifested by factors in the environment of growing broilers. Basically, continuous and pinpointed selection for rapid growth in broilers has led to higher oxygen demand and consequently to more frequent manifestation of an inherent potential cardiopulmonary incapability to sufficiently oxygenate the arterial blood. The multifaceted causes and modifiers of PHS make research into finding solutions to the syndrome a complex and multi threaded challenge. This research used several directions to better understand the development of PHS and to probe possible means of achieving a goal of monitoring and increasing resistance to the syndrome. Research Objectives (1) To evaluate the growth dynamics of individuals within breeding stocks and their correlation with individual susceptibility or resistance to PHS; (2) To compile data on diagnostic indices found in this work to be predictive for PHS, during exposure to experimental protocols known to trigger PHS; (3) To conduct detailed physiological evaluations of cardiopulmonary function in broilers; (4) To compile data on growth dynamics and other diagnostic indices in existing lines selected for susceptibility or resistance to PHS; (5) To integrate growth dynamics and other diagnostic data within appropriate statistical procedures to provide geneticists with predictive indices that characterize resistance or susceptibility to PHS. Revisions In the first year, the US team acquired the costly Peckode weigh platform / individual bird I.D. system that was to provide the continuous (several times each day), automated weighing of birds, for a comprehensive monitoring of growth dynamics. However, data generated were found to be inaccurate and irreproducible, so making its use implausible. Henceforth, weighing was manual, this highly labor intensive work precluding some of the original objectives of using such a strategy of growth dynamics in selection procedures involving thousands of birds. Major conclusions, solutions, achievements 1. Healthy broilers were found to have greater oscillations in growth velocity and acceleration than PHS susceptible birds. This proved the scientific validity of our original hypothesis that such differences occur. 2. Growth rate in the first week is higher in PHS-susceptible than in PHS-resistant chicks. Artificial neural network accurately distinguished differences between the two groups based on growth patterns in this period. 3. In the US, the unilateral pulmonary occlusion technique was used in collaboration with a major broiler breeding company to create a commercial broiler line that is highly resistant to PHS induced by fast growth and low ambient temperatures. 4. In Israel, lines were obtained by genetic selection on PHS mortality after cold exposure in a dam-line population comprising of 85 sire families. The wide range of PHS incidence per family (0-50%), high heritability (about 0.6), and the results in cold challenged progeny, suggested a highly effective and relatively easy means for selection for PHS resistance 5. The best minimally-invasive diagnostic indices for prediction of PHS resistance were found to be oximetry, hematocrit values, heart rate and electrocardiographic (ECG) lead II waves. Some differences in results were found between the US and Israeli teams, probably reflecting genetic differences in the broiler strains used in the two countries. For instance the US team found the S wave amplitude to predict PHS susceptibility well, whereas the Israeli team found the P wave amplitude to be a better valid predictor. 6. Comprehensive physiological studies further increased knowledge on the development of PHS cardiopulmonary characteristics of pre-ascitic birds, pulmonary arterial wedge pressures, hypotension/kidney response, pulmonary hemodynamic responses to vasoactive mediators were all examined in depth. Implications, scientific and agricultural Substantial progress has been made in understanding the genetic and environmental factors involved in PHS, and their interaction. The two teams each successfully developed different selection programs, by surgical means and by divergent selection under cold challenge. Monitoring of the progress and success of the programs was done be using the in-depth estimations that this research engendered on the reliability and value of non-invasive predictive parameters. These findings helped corroborate the validity of practical means to improve PHT resistance by research-based programs of selection.

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Zamecnik, J. R. Release of ammonia from HAN-type PHA. Office of Scientific and Technical Information (OSTI), June 1992. http://dx.doi.org/10.2172/6678726.

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Phillip Chrismon and Jason Dollarhide. Peoria Housing Authority(PHA) Weatherization Training Project. Office of Scientific and Technical Information (OSTI), December 2011. http://dx.doi.org/10.2172/1035169.

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Zamecnik, J. R. Release of ammonia from HAN-type PHA. Office of Scientific and Technical Information (OSTI), June 1992. http://dx.doi.org/10.2172/10112949.

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Lee, Ronald W., and Simon D. Rose. White Paper on Consequence Assessment of Transport of Hazardous Materials for PHMSA. Office of Scientific and Technical Information (OSTI), November 2018. http://dx.doi.org/10.2172/1523754.

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Edwards, T. B. Composition and property measurements for PHA Phase 1 glasses. Office of Scientific and Technical Information (OSTI), January 2000. http://dx.doi.org/10.2172/750855.

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Edwards, T. B. Composition and property measurements for PHA Phase 4 glasses. Office of Scientific and Technical Information (OSTI), January 2000. http://dx.doi.org/10.2172/750899.

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Edwards, T. B. Composition and property measurements for PHA Phase 3 glasses. Office of Scientific and Technical Information (OSTI), January 2000. http://dx.doi.org/10.2172/750900.

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