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Добірка наукової літератури з теми "Peptides Synthesis"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 6 вересня 2023

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Статті в журналах з теми "Peptides Synthesis"

1

Padalkar, Tanaji Dnyanadev. "Chemical Synthesis of Peptides." International Journal of Scientific Research 2, no. 2 (June 1, 2012): 147–49. http://dx.doi.org/10.15373/22778179/feb2013/49.

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2

Kang, Taek Jin, and Hiroaki Suga. "Ribosomal synthesis of nonstandard peptidesThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process." Biochemistry and Cell Biology 86, no. 2 (April 2008): 92–99. http://dx.doi.org/10.1139/o08-009.

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Анотація:

It is well known that standard peptides, which comprise proteinogenic amino acids, can act as specific chemical probes to target proteins with high affinity. Despite this fact, a number of peptide drug leads have been abandoned because of their poor cell permeability and protease instability. On the other hand, nonstandard peptides isolated as natural products often exhibit remarkable pharmaco-behavior and stability in vivo. Although it is likely that numerous nonstandard therapeutic peptides capable of recognizing various targets could have been synthesized, enzymes for nonribosomal peptide syntheses are complex; therefore, it is difficult to engineer such modular enzymes to build nonstandard peptide libraries. Here we describe an emerging technology for the synthesis of nonstandard peptides that employs an integrated system of reconstituted cell-free translation and flexizymes. We summarize the historical background of this technology and discuss its current and future applications to the synthesis of nonstandard peptides and drug discovery.

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3

Mourtas, Spyridon, Christina Katakalou, Dimitrios Gatos, and Kleomenis Barlos. "Convergent Synthesis of Thioether Containing Peptides." Molecules 25, no. 1 (January 5, 2020): 218. http://dx.doi.org/10.3390/molecules25010218.

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Thioether containing peptides were obtained following three synthetic routes. In route A, halo acids esterified on 2-chlorotrityl(Cltr) resin were reacted with N-fluorenylmethoxycarbonyl (Fmoc) aminothiols. These were either cleaved from the resin to the corresponding (Fmoc-aminothiol)carboxylic acids, which were used as key building blocks in solid phase peptide synthesis (SPPS), or the N-Fmoc group was deprotected and peptide chains were elongated by standard SPPS. The obtained N-Fmoc protected thioether containing peptides were then condensed either in solution, or on solid support, with the appropriate amino components of peptides. In route B, the thioether containing peptides were obtained by the reaction of N-Fmoc aminothiols with bromoacetylated peptides, which were synthesized on Cltr-resin, followed by removal of the N-Fmoc group and subsequent peptide elongation by standard SPPS. In route C, the thioether containing peptides were obtained by the condensation of a haloacylated peptide synthesized on Cltr-resin and a thiol-peptide synthesized either on 4-methoxytrityl(Mmt) or trityl(Trt) resin.

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4

Tanaka, Masayoshi, Shogo Saito, Reo Kita, Jaehee Jang, Yonghyun Choi, Jonghoon Choi, and Mina Okochi. "Array-Based Screening of Silver Nanoparticle Mineralization Peptides." International Journal of Molecular Sciences 21, no. 7 (March 30, 2020): 2377. http://dx.doi.org/10.3390/ijms21072377.

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Анотація:

The use of biomolecules in nanomaterial synthesis has received increasing attention, because they can function as a medium to produce inorganic materials in ambient conditions. Short peptides are putative ligands that interact with metallic surfaces, as they have the potential to control the synthesis of nanoscale materials. Silver nanoparticle (AgNP) mineralization using peptides has been investigated; however, further comprehensive analysis must be carried out, because the design of peptide mediated-AgNP properties is still highly challenging. Herein, we employed an array comprising 200 spot synthesis-based peptides, which were previously isolated as gold nanoparticle (AuNP)-binding and/or mineralization peptides, and the AgNP mineralization activity of each peptide was broadly evaluated. Among 10 peptides showing the highest AgNP-synthesis activity (TOP10), nine showed the presence of EE and E[X]E (E: glutamic acid, and X: any amino acid), whereas none of these motifs were found in the WORST25 (25 peptides showing the lowest AgNP synthesis activity) peptides. The size and morphology of the particles synthesized by TOP3 peptides were dependent on their sequences. These results suggested not only that array-based techniques are effective for the peptide screening of AgNP mineralization, but also that AgNP mineralization regulated by peptides has the potential for the synthesis of AgNPs, with controlled morphology in environmentally friendly conditions.

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5

Liu, Xuejian, Robert B. P. Elmes, and Katrina A. Jolliffe. "Synthesis of Side-Chain Modified Peptides Using Iterative Solid Phase ‘Click' Methodology." Australian Journal of Chemistry 70, no. 2 (2017): 201. http://dx.doi.org/10.1071/ch16567.

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A series of side-chain modified peptides have been prepared via an iterative sequence of peptide couplings and azide–alkyne cycloadditions (‘click’ reactions) using Fmoc-solid phase peptide synthesis. This efficient modular synthetic route allows the systematic and sequential incorporation of a variety of side-chain modifications onto short peptides. The versatility of this approach was demonstrated by the synthesis of a series of short peptides with appended anion recognition motifs and fluorescent indicators.

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6

Perich, JW, and RB Johns. "Synthesis of Casein-Related Peptides and Phosphopeptides. XV. The Efficient Synthesis of Multiple-Ser(P)-Containing Peptides." Australian Journal of Chemistry 44, no. 12 (1991): 1683. http://dx.doi.org/10.1071/ch9911683.

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Анотація:

The synthesis of Ac-Ser(P)- NHMe and multiple-Ser(P)-containing peptides Ac-Ser(P)-Ser(P)-NHMe and Ac-Ser(P)-Ser(P)-Ser(P)- NHMe is described. The use of Boc -Ser(PO3Ph2)-OH in the Boc mode of peptide synthesis for the preparation of the protected Ser(PO3Ph2)-containing peptides was followed by platinum-mediated hydrogenolytic deprotection.

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7

Liu, Dan, Ya-Li Guo, Jin Qu, and Chi Zhang. "Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis." Beilstein Journal of Organic Chemistry 14 (May 22, 2018): 1112–19. http://dx.doi.org/10.3762/bjoc.14.97.

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The system of the hypervalent iodine(III) reagent FPID and (4-MeOC6H4)3P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis. Four peptides with biological activities were synthesized through SPPS and the bioactive cyclic heptapeptide pseudostellarin D was obtained via solution-phase peptide synthesis. It is worth noting that FPID can be readily regenerated after the peptide coupling reaction.

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8

Yano, Shinya, Toshihiro Mori, and Hideki Kubota. "Silylated Tag-Assisted Peptide Synthesis: Continuous One-Pot Elongation for the Production of Difficult Peptides under Environmentally Friendly Conditions." Molecules 26, no. 12 (June 8, 2021): 3497. http://dx.doi.org/10.3390/molecules26123497.

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Анотація:

Addition of the silylated tag (STag) enables peptides to be highly soluble in CPME, allowing them to be used at high concentrations in a coupling reaction to enhance reactivity and achieve effective synthesis of sterically hindered peptides. We described the development of a continuous one-pot STag-assisted peptide synthesis platform as a method that provides near-stoichiometric, speedy, environmentally friendly, and scalable peptide synthesis.

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9

Carmona, Adriana K., Maria Aparecida Juliano, and Luiz Juliano. "The use of Fluorescence Resonance Energy Transfer (FRET) peptidesfor measurement of clinically important proteolytic enzymes." Anais da Academia Brasileira de Ciências 81, no. 3 (September 2009): 381–92. http://dx.doi.org/10.1590/s0001-37652009000300005.

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Анотація:

Proteolytic enzymes have a fundamental role in many biological processes and are associated with multiple pathological conditions. Therefore, targeting these enzymes may be important for a better understanding of their function and development of therapeutic inhibitors. Fluorescence Resonance Energy Transfer (FRET) peptides are convenient tools for the study of peptidases specificity as they allow monitoring of the reaction on a continuous basis, providing a rapid method for the determination of enzymatic activity. Hydrolysis of a peptide bond between the donor/acceptor pair generates fluorescence that permits the measurement of the activity of nanomolar concentrations of the enzyme. The assays can be performed directly in a cuvette of the fluorimeter or adapted for determinations in a 96-well fluorescence plate reader. The synthesis of FRET peptides containing ortho-aminobenzoic acid (Abz) as fluorescent group and 2, 4-dinitrophenyl (Dnp) or N-(2, 4-dinitrophenyl)ethylenediamine (EDDnp) as quencher was optimized by our group and became an important line of research at the Department of Biophysics of the Federal University of São Paulo. Recently, Abz/Dnp FRET peptide libraries were developed allowing high-throughput screening of peptidases substrate specificity. This review presents the consolidation of our research activities undertaken between 1993 and 2008 on the synthesis of peptides and study of peptidases specificities.

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10

Li, Wenyi, John D. Wade, Eric Reynolds, and Neil M. O'Brien-Simpson. "Chemical Modification of Cellulose Membranes for SPOT Synthesis." Australian Journal of Chemistry 73, no. 3 (2020): 78. http://dx.doi.org/10.1071/ch19335.

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Анотація:

Since the development of solid-phase peptide synthesis in the 1960s, many laboratories have modified the technology for the production of peptide arrays to facilitate the discovery of novel peptide mimetics and therapeutics. One of these, known as SPOT synthesis, enables parallel peptide synthesis on cellulose paper sheets and has several advantages over other peptide arrays methods. Today, the SPOT technique remains one of the most frequently used methods for synthesis and screening of peptides on arrays. Although polypropylene and glass can be used for the preparation of peptide arrays, the most commonly used material for SPOT membranes is cellulose. Critical to the success of the SPOT synthesis is the ability to modify a cellulose membrane to make it more suitable for solid-phase peptide synthesis of peptides and their analogues. In this review, we highlight the current range of chemical modifications of cellulose that have been developed to enable SPOT synthesis and further enhance its impact on peptide drug discovery. This will contribute to further chemical modifications and applications of SPOT synthesis for peptide arrays and peptide therapeutic screening.

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Дисертації з теми "Peptides Synthesis"

1

Chen, Fei, and 陳飛. "Studies on aminoxy peptides and prebiotic peptide formation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38534149.

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2

Swenson, Helen Rachel. "Studies in synthetic peptides and heterocyclic synthesis." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/13061.

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Анотація:

The following work documents three studies undertaken using solid phase synthesis techniques. Interaction of the zinc metalloprotease, endothelin converting enzyme-1(ECE-1), with its peptidic natural substrate big endothelum-1 has been investigated via an SAR study, using solid phase peptide synthesis (SPPS). Truncated forms of the substrate had been previously reported to inhibit ECE-1, this was confirmed however the big ET-1 analogues were shown to be substrates for the enzyme. A short study of the substrate specificity of ECE-1 was carried out. The synthesis of vast libraries of peptides using combinational synthesis has been used to accelerate the drug discovery process. Purification of these mixtures has not been previously attempted. 17-Tetrabenzo [a,c,g,i]fluoroeneyhethoxycarbonyl (Tbfmcc) developed for use with single peptides of proteins, has been used to achieve facile purification of five peptide libraries synthesised using SP. The methodology was fully optimised for the efficient separation of the desired library members from all impurities by exploiting the affinity of TBfmoc for carbon. A potential small molecule inhibitor of the zinc metalloenzyme, farnesyl transferase (FTase), was designed. The efficient solution phase synthesis of this novel structure is reported its adaptation to solid phase synthesis is described, with the view to using multiple parallel synthesis techniques to synthesise a range of analogous.

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3

Dillon, David Lawrence. "Peptide derivatives as pharmaceuticals : synthesis and reactions of n-thioacyl peptides." Thesis, Oxford Brookes University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327912.

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4

Lam, Hiu-yung, and 林曉勇. "Total synthesis of daptomycin and other cyclic peptides via Ser/Thr ligation-mediated peptide cyclization." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207198.

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Анотація:

Head-to-tail cyclic peptides with a wide range of ring sizes have been discovered in various organisms including bacteria, fungi, plants and animals. Many of them exhibit remarkable biological activities with high potency. Daptomycin, a cyclic lipodepsipeptide isolated from soil bacteria Stretomyces roseoporus, is the first natural product antibiotic launched in a generation. Daptomycin has potent bactericidal activity against otherwise antibiotic-resistant Gram-positive pathogens including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE) and vancomycin-resistant S. aureus. Daptomycin contains a 31-membered ring made up of 10 amino acids and a linear 3-amino acid side chain modified with an n-decanoyl lipid at the N-terminus. The complex structure of daptomycin, the presence of two non-proteinogenic amino acids (kynurenine and 3-methyl glutamic acid) and the macrolactamization of a 31-membered ring render daptomycin a challenging target for total synthesis. We recently developed a chemoselective serine/threonine ligation (STL) allowing peptide ligation at Ser/Thr site using side chain unprotected segments. We have successfully applied STL intramolecularly in the key cyclization step for the synthesis of daptomycin molecule, which allows us to finally achieve the first total synthesis of daptomycin. With this technique in hand, the chemical synthesis of daptomycin analogues, which are difficult to obtain otherwise becomes possible and is now ongoing. This would allow for the search for optimized analogues. We further investigated if STL could be applied for the synthesis of cyclic tetrapeptides, which are extremely difficult to be synthesized in the absence of turninducing components due to their rigid structural framework. To our delight, a series of cyclic tetrapeptides without any turn-inducing component, like Gly, Pro or Damino acids have been successfully synthesized by intramolecular STL. The synthesis of cyclic tetrapeptides with drug-like scaffold would be useful for the therapeutic development. We also applied intramolecular STL to successfully synthesize some natural cyclic peptides with different ring sizes, including anticancer stylopeptide 1, phakellistatin 4 and anti-inflammatory cyclosquamosin D.
published_or_final_version
Chemistry
Doctoral
Doctor of Philosophy

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5

Corrihons, Fabien. "Solid phase peptide synthesis of cyclic peptides for cancer oncology." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424312.

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6

Ndung'u, Susan Wanjiru. "The medicinal chemistry of cyclo(D-Phe-2Cl-Pro) and cyclo(Phe-4F-Pro)." Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/7083.

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Although peptides and proteins are considered as lead compounds for the discovery and development of new therapeutic agents, poor metabolic and physical properties have limited their optimisation as drug candidates (Adessi & Soto, 2002). Research by medicinal chemists however, generated the discovery of structural similarities between some peptides and diketopiperazines and the common occurrence of such compounds in natural products. This discovery initiated the synthesis of diketopiperazines from amino acids in an attempt to bypass the previously mentioned limitations of using peptides as drug candidates (Dinsmore & Beshore, 2002). Diketopiperazines (DKPs) are the simplest form of cyclic dipeptides, and a class of unexplored bioactive peptides that have great potential for the future. The compounds are relatively simple to synthesise and are prevalent in nature (Prasad, 1995). The DKP backbone is rigid and therefore poses conformational constraint on the compounds. This rigidity allows for simple conformational analysis of the compounds and also gives insight into the conformational requirements for interaction with the targets involved in their biological activity. The reduced conformational freedom also increases the receptor specificity and thus the compounds are proposed to have less unfavourable effects (Anteunis, 1978). The aim of the study was to synthesise compounds that would exhibit metabolic stability, receptor specificity and enhanced lipophilicity which would increase the bioavailability of the compounds. This was to be achieved by the introduction of fluorine and chlorine elements into the DKPs. The structure of the DKPs would be altered which in turn would improve the physicochemical properties and the biological activity of the compounds (Naumann, 1999). Cyclo(D-Phe-2Cl-Pro) and cyclo(Phe-4F-Pro) were synthesised using the method of Milne et al. (1992) and by boiling the linear counterparts under reflux in sec-butanol-toluene. The structures of the synthesised DKPs were elucidated using mass spectrometry, nuclear magnetic resonance spectroscopy, infrared spectroscopy and molecular modeling. Qualitative analysis and evaluation of the physicochemical properties of the DKPs were performed using high-performance liquid chromatography, scanning electron microscopy, thermogravimetric analysis, differential scanning calorimetry and x-ray powder diffraction. The study aimed to determine the biological activity of cyclo(D-Phe-2Cl-Pro) and cyclo(Phe-4F-Pro) with respect to their anticancer, antimicrobial, haematological and antidiabetic effects. The anticancer results obtained indicated that the percentage inhibition produced by both DKPs were lower than those proposed by Graz et al. (2000) for proline-containing DKPs where, a greater than 50% inhibition was observed for cyclo(Phe-Pro). Antimicrobial studies revealed that both DKPs demonstrated marginal effects on Gram-positive and Gram-negative organisms but showed significant effects against C. albicans. The haematological studies revealed that cyclo(D-Phe-2Cl-Pro) at a screening concentration of 12.5 mM, significantly decreased the levels of D-dimer (P < 0.0001). The antidiabetics studies showed limited activity of the DKPs in inhibiting the activity of α-glucosidase and α-amylase enzymes.

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7

Sieber, Stephan Axel. "Nonribosomal peptide synthetases quaternary structure and chemoenzymatic synthesis of macrocyclic peptides /." [S.l.] : [s.n.], 2004. http://archiv.ub.uni-marburg.de/diss/z2004/0218/.

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8

Irving, Stephen L. "Synthesis and purification of peptides." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/28282.

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Improved routes to tetrabenz[a,c,g,i]fluorene derivatives have been developed, allowing the synthesis of N^α-17-tetrabenzo[a,c,g,i]fluorenyl-methoxycarbonyl (tbfmoc) urethane derivatives of alanine, leucine, isoleucine, methionine and valine. The chloroformate and pentafluorophenyl carbonate of 17-tetrabenzo[a,c,g,]fluorenylmethanol have been prepared and used to introduce the base-labile Tbrmoc group onto the N^α-termini of resin-bound peptides. The high affinity of the Tbrmoc group for porous graphitised carbon (PGC) has been exploited for the purification of a range of synthetic peptides (23-85 residues). A comparison of various basic solvent systems used to elute the purified peptide from PGC is presented. The hydrophobicity of the Tbfmoc group has been used to simplify the purification of a ubiquitin analogue, UbY59F (76 residues), by the enhanced retention of the Tbfmoc peptide on RP-HPLC. A new synthesis of 2-hydroxydibenzocycloheptadien-5-one has been advised. This compound has been used to develop acid-labile linkers for the synthesis of peptide C-terminal alkyl amides and aza-glycine peptides, compatible with the Fmoc/^tBu solid phase method. Alternative modes of attachment of the linker to polystyrene resin are compared for the synthesis of bombesin, a peptide amide.

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9

Alexander, Mcmanamara Linda Mary. "Synthesis of stable - helical peptides." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398920.

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10

Martari, Marco. "Structure-function relationships of bolaamphiphilic peptides and peptide hybrids." Thesis, Link to the online version, 2006. http://hdl.handle.net/10019/582.

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Книги з теми "Peptides Synthesis"

1

The chemical synthesis of peptides. Oxford: Clarendon Press, 1991.

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2

1949-, Basava Channa, and Anantharamaiah G. M. 1947-, eds. Peptides: Design, synthesis, and biological activity. Boston: Birkhäuser, 1994.

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3

Sidney, Udenfriend, and Meienhofer Johannes, eds. The Peptides: Analysis, synthesis, biology. San Diego, Calif: Academic Press, 1987.

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4

Sidney, Udenfriend, Meienhofer Johannes, and Smith Clark W, eds. The Peptides: Analysis, synthesis, biology. Orlando: Academic Press, 1987.

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5

Peptide synthesis and applications. 2nd ed. New York: Humana Press, 2013.

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6

Labsystems Research Symposium on Synthetic Peptides in Biology and Medicine (1985 Hämeenlinna, Finland). Synthetic peptides in biology and medicine: Proceedings of the Labsystems Research Symposium on Synthetic Peptides in Biology and Medicine held in Hämeenlinna, Finland, on June 6-8, 1985. Edited by Alitalo Kari, Partanen Paul, Vaheri Antti, and Labsystems (Firm). Amsterdam: Elsevier Science Publishers, 1985.

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7

D, Fricker Lloyd, ed. Peptide biosynthesis and processing. Boca Raton: CRC Press, 1991.

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8

W, Pennington Michael, and Dunn Ben M, eds. Peptide synthesis protocols. Totowa, N.J: Humana Press, 1994.

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9

Bodanszky, M. The practice of peptide synthesis. 2nd ed. Berlin: Springer-Verlag, 1994.

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10

1926-, Theodoropoulos Dimitrios, ed. Peptides, 1986: Proceedings of the 19th European Peptide Symposium, Porto Carras, Chalkidiki, Greece, August 31-September 5, 1986. Berlin: W. de Gruyter, 1987.

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Частини книг з теми "Peptides Synthesis"

1

Frank, R., H. Leban, M. Kraft, and H. Gausepohl. "Continuous flow peptide synthesis." In Peptides, 215–16. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-010-9595-2_63.

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2

Wendlberger, G., W. Göhring, G. Hübener, R. Scharf, J. Beythien, Ch Beglinger, and E. Wünsch. "Synthesis of human secretin." In Peptides, 287–88. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-010-9595-2_87.

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3

Xu, Jie-cheng, Ming-zhu Zhang, Shi-yi Liu, and Yi Zhang. "Synthesis of muramyl peptides." In Peptides, 259–60. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-010-9066-7_75.

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4

Evans, David A., Ann E. Weber, Thomas C. Britton, Jonathan A. Ellman, and Eric B. Sjogren. "Asymmetric synthesis of amino acids." In Peptides, 143–48. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-010-9595-2_42.

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5

Thorbek, Pia, Jørn Lauridsen, and Fred Widmer. "Protease-catalyzed synthesis of oxytocin." In Peptides, 279–81. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-010-9595-2_84.

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6

Gruber, S. M., P. Yu-Yang, and S. P. A. Fodor. "Light-directed combinatorial peptide synthesis." In Peptides, 489–91. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2264-1_187.

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7

Albericio, Fernando, Paul Lloyd-Williams, Margarida Gairí, Gemma Jou, Ramon Eritja, and Ernest Giralt. "Convergent solid-phase peptide synthesis." In Peptides, 607–8. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2264-1_240.

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8

Kagel, John R., James L. Kofron, and Daniel H. Rich. "Synthesis of 5-fluoroproline derivatives." In Peptides, 818–19. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2264-1_331.

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9

Wijkmans, J. C. H. M., J. H. van Boom, and W. Bloemhoff. "Peptide synthesis by insertion reactions." In Peptides, 133–35. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-0683-2_39.

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10

Benovitz, D. E., K. Darlak, W. A. Klis, E. Klein, and A. F. Spatola. "Membrane based peptide synthesis (MBPS)." In Peptides, 136–37. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-0683-2_40.

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Тези доповідей конференцій з теми "Peptides Synthesis"

1

Stüber, W., H. Pelzer, and N. Heimburger. "INDUCTION OF ANTITHROMBIN III (AT III) ANTIBODIES BY IMMUNIZATION WITH SYNTHETIC PEPTIDES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644355.

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Анотація:

The primary structure of AT III was examined in respect of potential antigenic sites. The topics were the determination of the hydrophilicity, hydropathy, acrophilicity and the propensities for alpha-helices, B-turns and 13-sheets. The peptides AT III 21-34, 21-42, 129 - 140, 226 - 240 and 343 -363 were synthesized using the solid phase peptide synthesis methode. The subsequent purification of the crude peptides was achieved by h.p.I.e. or by ion exchange chromatography. The peptides were coupled to keyhole limpet hemocyanine (KLH) via thioether bonds. Antisera against KLH-peptides were raised in rabbits (n = 25) and tested with AT III-coated polystyrene tubes; bound antibodies were detected with anti-rabbit-IgG-peroxidase. Obtained antisera were further purified by immuno-adsorption using immobilized AT III. Polystyrene tubes were coated with purified peptide antibodies and binding of AT III was studied with enzyme immunoassay technique (EIA) using anti-AT III-peroxidase.As a result, immunoreactivity of rabbit antisera against synthetic peptides of AT III could be achieved. The obtained antibodies against the individual synthetic peptides as well as their mixtures exhibited specific binding to AT III when tested with EIA.

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2

Sakakibara, Shumpei. "Solution synthesis of peptides." In Future Aspect in Peptide Chemistry - Ringberg Conference. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199901001.

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3

Biondi, Barbara, Silvia Millan, Fernando Formaggio, Alessandra Semenzato, and Cristina Peggion. "Synthesis and conformationof short peptides modeled after peptide LL-37." In 35th European Peptide Symposium. Prompt Scientific Publishing, 2018. http://dx.doi.org/10.17952/35eps.2018.195.

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4

Hradilek, Martin, Markéta Rinnová, Cyril Bařinka, Milan Souček, and Jan Konvalinka. "Synthesis of library of HIV proteases inhibitors." In VIth Conference Biologically Active Peptides. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199903079.

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5

Klein, Jens-Uwe, and Václav Čeřovský. "Enzymatic peptide synthesis – simulation of nucleophile excess." In VIth Conference Biologically Active Peptides. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199903094.

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6

Dzimbova, Tatiana A., Tamara I. Pajpanova, and Evgeny V. Golovinsky. "Synthesis of some sulfoguanidino group-containing amino acids." In VIIIth Conference Biologically Active Peptides. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2003. http://dx.doi.org/10.1135/css200306012.

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7

Vezenkov, Ljubomir, Dantcho Danalev, and Boriana Grigorova. "Synthesis of new analogues of antistasin and ghilantens." In VIIIth Conference Biologically Active Peptides. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2003. http://dx.doi.org/10.1135/css200306115.

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8

Zompra, Aikaterini, Dimitris Vachliotis, Georgios A. Spyroulias, Vassiliki Magafa, and Paul Cordopatis. "Synthesis and structural investigation of new Leuprolide analogues." In VIIIth Conference Biologically Active Peptides. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2003. http://dx.doi.org/10.1135/css200306122.

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9

Banachewicz, Wiktor, Łukasz P. Frankiewicz та Aleksandra Misicka. "Synthesis and structural characterisation of Aβ peptide fragments". У IXth Conference Biologically Active Peptides. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200508004.

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10

Hlaváček, Jan, Blanka Bennettová, Bohuslav Černý, Věra Vlasáková, Jiřina Slaninová, Josef Holík, and Richard Tykva. "Synthesis and utilization of peptides containing 3,4-dehydroproline." In IXth Conference Biologically Active Peptides. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200508028.

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Звіти організацій з теми "Peptides Synthesis"

1

Atassi, M. Z. Synthesis and Activity of Oxygen-Carrying Heme Peptides. Fort Belvoir, VA: Defense Technical Information Center, November 2004. http://dx.doi.org/10.21236/ada428126.

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2

Atassi, M. Z. Design & Synthesis of Oxygen-Binding Heme Peptides. Fort Belvoir, VA: Defense Technical Information Center, July 1990. http://dx.doi.org/10.21236/ada224458.

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3

Vouros, Paul, and Terrance Black. Solid Phase Peptide Synthesis of Antimicrobial Peptides for cell Binding Studies: Characterization Using Mass Spectrometry. Fort Belvoir, VA: Defense Technical Information Center, November 2002. http://dx.doi.org/10.21236/ada412571.

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4

Altstein, Miriam, and Ronald Nachman. Rationally designed insect neuropeptide agonists and antagonists: application for the characterization of the pyrokinin/Pban mechanisms of action in insects. United States Department of Agriculture, October 2006. http://dx.doi.org/10.32747/2006.7587235.bard.

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The general objective of this BARD project focused on rationally designed insect neuropeptide (NP) agonists and antagonists, their application for the characterization of the mechanisms of action of the pyrokinin/PBAN (PK-PBAN) family and the development of biostable, bioavailable versions that can provide the basis for development of novel, environmentally-friendly pest insect control agents. The specific objectives of the study, as originally proposed, were to: (i) Test stimulatory potencies of rationally designed backbone cyclic (BBC) peptides on pheromonotropic, melanotropic, myotropic and pupariation activities; (ii) Test the inhibitory potencies of the BBC compounds on the above activities evoked either by synthetic peptides (PBAN, LPK, myotropin and pheromonotropin) or by the natural endogenous mechanism; (iii) Determine the bioavailability of the most potent BBC compounds that will be found in (ii); (iv) Design, synthesize and examine novel PK/PBAN analogs with enhanced bioavailability and receptor binding; (v) Design and synthesize ‘magic bullet’ analogs and examine their ability to selectively kill cells expressing the PK/PBAN receptor. To achieve these goals the agonistic and antagonistic activities/properties of rationally designed linear and BBC neuropeptide (NP) were thoroughly studied and the information obtained was further used for the design and synthesis of improved compounds toward the design of an insecticide prototype. The study revealed important information on the structure activity relationship (SAR) of agonistic/antagonistic peptides, including definitive identification of the orientation of the Pro residue as trans for agonist activity in 4 PK/PBANbioassays (pheromonotropic, pupariation, melanotropic, & hindgut contractile) and a PK-related CAP₂b bioassay (diuretic); indications that led to the identification of a novel scaffold to develop biostbiostable, bioavailable peptidomimetic PK/PBANagonists/antagonists. The work led to the development of an arsenal of PK/PBAN antagonists with a variety of selectivity profiles; whether between different PKbioassays, or within the same bioassay between different natural elicitors. Examples include selective and non-selective BBC and novel amphiphilic PK pheromonotropic and melanotropic antagonists some of which are capable of penetrating the moth cuticle in efficacious quantities. One of the latter analog group demonstrated unprecedented versatility in its ability to antagonize a broad spectrum of pheromonotropic elicitors. A novel, transPro mimetic motif was proposed & used to develop a strong, selective PK agonist of the melanotropic bioassay in moths. The first antagonist (pure) of PK-related CAP₂b diuresis in flies was developed using a cisPro mimetic motif; an indication that while a transPro orientation is associated with receptor agonism, a cisPro orientation is linked with an antagonist interaction. A novel, biostablePK analog, incorporating β-amino acids at key peptidase-susceptible sites, exhibited in vivo pheromonotropic activity that by far exceeded that of PBAN when applied topically. Direct analysis of neural tissue by state-of-the-art MALDI-TOF/TOF mass spectrometry was used to identify specific PK/PK-related peptides native to eight arthropod pest species [house (M. domestica), stable (S. calcitrans), horn (H. irritans) & flesh (N. bullata) flies; Southern cattle fever tick (B. microplus), European tick (I. ricinus), yellow fever mosquito (A. aegypti), & Southern Green Stink Bug (N. viridula)]; including the unprecedented identification of mass-identical Leu/Ile residues and the first identification of NPs from a tick or the CNS of Hemiptera. Evidence was obtained for the selection of Neb-PK-2 as the primary pupariation factor of the flesh fly (N. bullata) among native PK/PK-related candidates. The peptidomic techniques were also used to map the location of PK/PK-related NP in the nervous system of the model fly D. melanogaster. Knowledge of specific PK sequences can aid in the future design of species specific (or non-specific) NP agonists/antagonists. In addition, the study led to the first cloning of a PK/PBAN receptor from insect larvae (S. littoralis), providing the basis for SAR analysis for the future design of 2ⁿᵈgeneration selective and/or nonselective agonists/antagonists. Development of a microplate ligand binding assay using the PK/PBAN pheromone gland receptor was also carried out. The assay will enable screening, including high throughput, of various libraries (chemical, molecular & natural product) for the discovery of receptor specific agonists/antagonists. In summary, the body of work achieves several key milestones and brings us significantly closer to the development of novel, environmentally friendly pest insect management agents based on insect PK/PBANNPs capable of disrupting critical NP-regulated functions.

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5

Judd, Amrit K. Active Antitoxic Immunization against Ricin Using Synthetic Peptides. Fort Belvoir, VA: Defense Technical Information Center, August 1989. http://dx.doi.org/10.21236/adb137490.

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6

Author, Not Given. [Synthetic adhesive peptides for clinical imaging]. Final report. Office of Scientific and Technical Information (OSTI), December 1994. http://dx.doi.org/10.2172/10130310.

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7

Bredesen, Dale. Novel Synthetic Hunter-Killer Peptides Target and Destroy Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, September 1999. http://dx.doi.org/10.21236/ada384822.

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8

Kennedy, Ronald C. Use of Synthetic Peptides Anti-Idiotypes for Controlling Human Immunodeficiency Virus Infection. Fort Belvoir, VA: Defense Technical Information Center, August 1992. http://dx.doi.org/10.21236/ada269558.

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9

Haynes, Barton F. Structural and Functional Studies of Experimental HIV Synthetic Peptide Immunogens. Fort Belvoir, VA: Defense Technical Information Center, October 1997. http://dx.doi.org/10.21236/ada333309.

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10

Hwu, Chia-Yu, and Daniel Harvey. Design, Synthesis and Study of Cell Adhesion Antagonists: Hydroxamate-Based Peptide Inhibitors of avb3 Integrin. Fort Belvoir, VA: Defense Technical Information Center, July 2000. http://dx.doi.org/10.21236/ada384216.

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