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Добірка наукової літератури з теми "Osteoarthritis"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 1 серпня 2024

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Статті в журналах з теми "Osteoarthritis"

Abdelhameed, Abdelrahman Mohamed Galal, Said Mahmoud Mohamed Hani, and Ahmed Mohamed Mohamed Soliman. "Effects of Locally Delivered Morin Hydrate on Iodoacetate-induced Temporomandibular Joint Osteoarthritis in Rats." Brazilian Dental Science 23, no. 4 (September 30, 2020): 11p. http://dx.doi.org/10.14295/bds.2020.v23i4.1904.

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Objectives: morin hydrate has been reported to possess many beneficial pharmacological potentialities including antioxidant and anti-osteoarthritic effects. The antiosteoarthritic properties of locally administrated morin have not been investigated. The objective of this study is to evaluate the locally delivered morin on the temporomandibular joint osteoarthritis in rat. Materials and methods: thirty young adult female Sprague Dawley rats were randomly arranged into three groups; control, osteoarthritis and osteoarthritis with morin. Both the iodoacetate for osteoarthritis induction and morin hydrate therapy were delivered unilaterally via intra-articular route. Results: morin reduced osteoarthritis manifestations with prominent thickening of both condylar fibrous layer and articular disc accompanied with discal cells hypertrophy that ultimately acquired chondrocytes features. The condylar cartilage matrix showed enhancement of extracellular matrix production with morin administration. Discussion: the present study has elucidated antiosteoarthritic effect of intraarticular injection of morin hydrate. Although morin has managed to prevent the propagation and advancing some of the recorded osteoarthritic manifestations; however, it showed some failure in managing others. The administration of morin hydrate modulated the structure of the joint rather than restore it back to its typical configuration. Conclusion: the morin hydrate administration to osteoarthritic animals showed relieve in some of osteoarthritic features and modulated the structure of some joint components to compensate the unhandled manifestations.KEYWORDSIodoacetate; Morin; Osteoarthritis; OARSI Score; Temporomandibular joint.

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Yang, Tzi-Peng, Hsiao-Mei Chen, Chao-Chin Hu, Li-Yuan Chen, Fen-Fen Shih, Disline Manli Tantoh, Kuan-Jung Lee, Yi-Chia Liaw, Rong-Tzong Tsai, and Yung-Po Liaw. "Interaction of Osteoarthritis and BMI on Leptin Promoter Methylation in Taiwanese Adults." International Journal of Molecular Sciences 21, no. 1 (December 23, 2019): 123. http://dx.doi.org/10.3390/ijms21010123.

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Leptin (LEP) regulates glucose metabolism and energy storage in the body. Osteoarthritis (OA) is associated with the upregulation of serum LEP. LEP promoter methylation is associated with obesity. So far, few studies have explored the association of BMI and OA with LEP methylation. We assessed the interaction between body mass index (BMI) and OA on LEP promoter methylation. Data of 1114 participants comprising 583 men and 558 women, aged 30–70 years were retrieved from the Taiwan Biobank Database (2008–2015). Osteoarthritis was self-reported and cases were those who reported having ever been clinically diagnosed with osteoarthritis. BMI was categorized into underweight, normal weight, overweight, and obesity. The mean LEP promoter methylation level in individuals with osteoarthritis was 0.5509 ± 0.00437 and 0.5375 ± 0.00101 in those without osteoarthritis. The interaction between osteoarthritis and BMI on LEP promoter methylation was significant (p-value = 0.0180). With normal BMI as the reference, the mean LEP promoter methylation level was significantly higher in obese osteoarthritic individuals (β = 0.03696, p-value = 0.0187). However, there was no significant association between BMI and LEP promoter methylation in individuals without osteoarthritis, regardless of BMI. In conclusion, only obesity was significantly associated with LEP promoter methylation (higher levels) specifically in osteoarthritic patients.

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LI, H., X. Jiang, Y. Xiao, Y. Zhang, W. Zhang, M. Doherty, N. Jacquelyn, et al. "POS0329 CHONDROCYTE SUBPOPULATIONS AND CANONICAL PATHWAYS ASSOCIATED WITH HAND OSTEOARTHRITIS: DISCOVERY BY SINGLE-CELL TRANSCRIPTOMIC ANALYSIS AND VALIDATION BY TWO INDEPENDENT POPULATION-BASED STUDIES." Annals of the Rheumatic Diseases 82, Suppl 1 (May 30, 2023): 410–11. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4327.

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BackgroundHand osteoarthritis is a common heterogeneous joint disorder with differences in aetiology and pathophysiology from the large weight-bearing knee or hip osteoarthritis.[1]-[3]Its pathophysiological mechanism remains largely unexplored, partially because of limited access to clinical sample tissues and lack of animal models.[2]To date, there is no known cure for hand osteoarthritis, indicating an urgent need for better understanding of the underlying mechanisms so that appropriate treatment strategies can be developed to target this disabling disease.ObjectivesWe aimed to identify hand joint chondrocyte subpopulations and investigate the molecular mechanism of hand osteoarthritis by performing single-cell RNA sequencing (scRNA-seq) analysis, and verify the findings in two large independent population-based studies.MethodsWe obtained hand interphalangeal joints from five donors who had destructive forearm injury. Using scRNA-seq analysis, we analysed the cellular composition and subpopulation-specific gene expression of hand articular cartilage, and then compared these features between cartilages from joints with macroscopically confirmed osteoarthritis and those without osteoarthritis. To verify the findings, we conducted a Mendelian randomisation study in the UK Biobank and a cross-sectional study using data collected from the Xiangya Osteoarthritis Study. Figure 1 shows the schematic illustration of this study.ResultsOf 105,142 cells we identified 13 subpopulations, including a novel inflammatory chondrocyte subpopulation that specifically expressed genes related to inflammatory and immune response. Fibrocartilage chondrocytes represented a major source of osteoarthritis-related proteases and exhibited an extensive alteration of gene expression patterns in osteoarthritic cartilage compared with non-osteoarthritic cartilage. Both inflammatory chondrocytes and fibrocartilage chondrocytes showed a trend towards increased numbers in osteoarthritic cartilage. In these two subpopulations from osteoarthritic cartilage, the ferroptosis pathway was enriched, in which the expression of iron overload-related genes, eg,FTH1, was elevated. These findings are further validated by two independent population-based studies. Among participants (n=332,668) in the UK Biobank, genetic predisposition to higher expression ofFTH1mRNA significantly increased the risk of hand osteoarthritis (OR=1·07, 95%CI:1·02-1·11). Among participants (n=1,241) from the Xiangya Osteoarthritis Study, high levels of serum ferritin (encoded byFTH1), a biomarker of body iron overload, were significantly associated with a high prevalence of hand osteoarthritis (P-for-trend=0·037).ConclusionOur datasets will be valuable as a rich resource for molecular and cellular exploration and open new possibilities for the research of molecular mechanism, drug development and precise treatment for hand osteoarthritis. Inflammatory and fibrocartilage chondrocytes are key subpopulations and ferroptosis may be a key pathway in hand osteoarthritis. Markers of these chondrocyte subpopulations, as well as ferroptosis inhibitors or iron chelators, could be focus of attention in future studies.References[1]Kloppenburg M, Kwok WY. Hand osteoarthritis--a heterogeneous disorder.Nat Rev Rheumatol2011;8(1):22-31.[2]Marshall M, Watt FE, Vincent TL, et al. Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management.Nat Rev Rheumatol2018;14(11):641-56.[3]Haugen IK, Englund M, Aliabadi P, et al. Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study.Annals of the rheumatic diseases2011;70(9):1581-6.Figure 1.The schematic illustration of this study.AcknowledgementsThis work was supported by the National Natural Science Foundation of China (81930071, 82072502, 81902265), the National Natural Science Foundation Regional Innovation and Development Joint Fund (U21A20352), Project Program of National Clinical Research Center for Geriatric Disorders (Xiangya Hospital, 2021LNJJ06, 2022LNJJ07), the Natural Science Foundation of Hunan Province (2022JJ20100), and Central South University Innovation-Driven Research Programme (2023CXQD031).Disclosure of InterestsNone Declared.

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Myszka, Anna, Janusz Piontek, Jacek Tomczyk, and Marta Zalewska. "Osteoarthritis – a problematic skeletal trait in past human populations. Osteoarthritic changes vs. entheseal changes in the late medieval and early modern population form Łekno." Anthropological Review 83, no. 2 (June 1, 2020): 143–61. http://dx.doi.org/10.2478/anre-2020-0011.

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AbstractAccording to medical knowledge, physical activity plays a role in osteoarthritic changes formation. The impact of occupation on osteoarthritic changes development in past human populations is not clear enough, causing problems with interpretation. The aim of the current study is to examine the relationship between osteoarthritis and entheseal changes. Skeletal material comes from the late medieval, early modern population from Łekno (Poland). The sample consists of 110 males and 56 females (adults only). Osteophytes, porosity and eburnation were analyzed in the shoulder, elbow, wrist, hip, knee, and ankle. Entheses on the humerus, radius, femur, and tibia were examined. Standard ranked categorical scoring systems were used for the osteoarthritic and entheseal changes examination.Males with more developed osteophytes in the shoulder have more “muscular” upper limbs (higher values of muscle markers). Males with more developed osteophytes in the hip and knee are predicted to have more “muscular” lower limbs. Males with more developed osteoarthritis in the shoulder, wrist, hip, and knee exhibit more developed entheseal changes. Males with more developed entheses tend to yield more developed osteophytes (all joints taken together) and general osteoarthritis (all changes and all joints taken together). Females with more developed entheses have more developed osteoarthritis in the elbow, wrist, and hip. Individuals with more developed entheses have much more developed osteophytes. When all the three types of changes are taken together, more “muscular” females exhibit more developed osteoarthritis. The lack of uniformity of the results, wild discussions on the usage of entheses in activity patterns reconstruction and other limitations do not allow to draw unambiguous conclusions about the impact of physical activity on the osteoarthritis in past populations and further studies are needed.

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Ekeuku, Sophia Ogechi, Fairus Ahmad, and Kok-Yong Chin. "Changes of Grip Strength, Articular Cartilage and Subchondral Bone in Monoiodoacetate-Induced Osteoarthritis in Rats." Sains Malaysiana 51, no. 11 (November 30, 2021): 3741–54. http://dx.doi.org/10.17576/jsm-2022-5111-18.

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Osteoarthritis is a degenerative disease affecting articular cartilage among the elderly. The intra-articular monoiodoacetate injection is one of the most widely used methods to induce osteoarthritis in animals. While the effects of monoiodoacetate on cartilage are well-characterized, its effects on subchondral bone remodeling are less studied. The purpose of this study was to determine the changes of the grip strength, articular cartilage structure and subchondral bone remodeling in monoiodoacetate-induced osteoarthritis in rats. Three-month-old male Wistar rats were assigned to normal control (n=6) and osteoarthritis group (n=6), which received intra-articular injection of 4 mg/50 µL monoiodoacetate solution once at the left knee of hindlimb. The rats were monitored for four weeks. The grip strength test was performed before injection and every week after injection. After four weeks, the femurs with intact cartilage were harvested for histomorphological analysis. Grip strength was reduced significantly in the osteoarthritic rats compared to the normal rats (p<0.05). Food intake was reduced significantly one week following monoiodoacetate-induction (p<0.05), but it stabilized afterwards. Monoiodoacetate injection increased cartilage erosion and osteoclast number in the subchondral bone of the osteoarthritic rats compared to the normal rats (p<0.05). However, it did not affect body weight, subchondral bone osteoblast activity, mineralization and microstructure of osteoarthritic rats (p>0.05). As a conclusion, monoiodoacetate-induced osteoarthritis affects the cartilage and increases osteoclast formation in the subchondral bone of rats.

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Mabey, Thomas, and Sittisak Honsawek. "Role of Vitamin D in Osteoarthritis: Molecular, Cellular, and Clinical Perspectives." International Journal of Endocrinology 2015 (2015): 1–14. http://dx.doi.org/10.1155/2015/383918.

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Osteoarthritis is a debilitating and degenerative disease which affects millions of people worldwide. The causes and mechanisms of osteoarthritis remain to be fully understood. Vitamin D has been hypothesised to play essential roles in a number of diseases including osteoarthritis. Many cell types within osteoarthritic joints appear to experience negative effects often at increased sensitivity to vitamin D. These findings contrast clinical research which has identified vitamin D deficiency to have a worryingly high prevalence among osteoarthritis patients. Randomised-controlled trial is considered to be the most rigorous way of determining the effects of vitamin D supplementation on the development of osteoarthritis. Studies into the effects of low vitamin D levels on pain and joint function have to date yielded controversial results. Due to the apparent conflicting effects of vitamin D in knee osteoarthritis, further research is required to fully elucidate its role in the development and progression of the disease as well as assess the efficacy and safety of vitamin D supplementation as a therapeutic strategy.

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Reeni.D, Bijilin, and George Joe Kumar. A. "A Study to Evaluate the Effectiveness of Aloe Vera Gel on Pain Perception among Patients with Osteoarthritis at Selected Communities in Kanyakumari District." Galore International Journal of Applied Sciences and Humanities 5, no. 4 (December 28, 2021): 54–60. http://dx.doi.org/10.52403/gijash.20211009.

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Aim: to evaluate the effectiveness of Aloe Vera gel on pain perception among patients with osteoarthritis in selected communities at Kanyakumari district. Objectives: (i) To assess and compare the pre-test and post-test level of pain perception among patients with osteoarthritis in experimental and control group. (ii) To evaluate the effectiveness of Aloe Vera gel on level of pain perception among patients with osteoarthritis in experimental group. (iii) To find out the association between the post-test level of pain perception among patients with osteoarthritis in experimental group and control group with the selected demographic variables. A Quasi experimental, non-equivalent, pre test and post test control group design was adopted. The convenience sampling technique was used to select 30 samples for experimental group and 30 samples for control group. OARSI (osteoarthritis research society international) questionnaire was used to assess the osteoarthritic pain. Aloe Vera gel was applied locally on painful areas for 28 consequent days and post test was conducted on 28th day by using OARSI questionnaire. The data were gathered and analyzed by descriptive and inferential statistical method. The findings revealed that during pre test 20(67%) of them had moderate pain, 10(33%) of them had mild pain. During post test 19(63%) of them were in mild pain, 11(37%) of them were in moderate pain. The mean score on level of pain perception among patients with osteoarthritis was 33.3 in pre test and 22 in post test. The estimated t’ value was 8.99* which is significant at p < 0.05. It shows that local application of Aloe Vera gel was effective in reducing the level of pain perception among osteoarthritis pain. Hence the research hypothesis H1 is retained. This study statistically proved the pain reducing effect of Aloe Vera gel on Osteoarthritic patients at 5% significant level. The researcher concluded that Aloe Vera gel application is a non pharmacological, cost effective and very practicable measure to reduce the level of pain perception among patients with osteoarthritis. Keywords: Aloe Vera gel, Pain perception, Osteoarthritis.

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Kriplani, Priyanka, Kumar Guarve, and Uttam Singh Baghel. "Novel Herbal Topical Patch Containing Curcumin and Arnica montana for the Treatment of Osteoarthritis." Current Rheumatology Reviews 16, no. 1 (March 5, 2020): 43–60. http://dx.doi.org/10.2174/1573397115666190214164407.

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Background: Osteoarthritis (OA) ranks fifth among all forms of disability affecting 10% of the world population. Current treatments available are associated with multiple side effects and do not slow down the progression of the disease. Moreover, no such effective treatment is available to date in various systems of medicine to treat osteoarthritis. Curcumin and Arnica have shown evident clinical advances in the treatment of osteoarthritis. Objective: The aim of the present study was to design, optimize and characterize novel herbal transdermal patches of curcumin and Arnica montana using factorial design. Methods: A multiple factorial design was employed to investigate the effect of hydroxypropyl methyl cellulose, ethyl cellulose and jojoba oil on elongation and drug release. Transdermal patches were evaluated by FTIR, DSC, FESEM, ex vivo drug permeation, anti osteoarthritic activity and analgesic activity. Results: Independent variables exhibited a significant effect on the physicochemical properties of the prepared formulations. The higher values of drug release and elongation were observed with the higher concentration of hydroxypropyl methylcellulose and jojoba oil. Anti osteoarthritic activity was assessed by complete Freund's adjuvant arthritis model; using rats and analgesic activity by Eddy's hot plate method, using mice. Combination patch exhibited good anti osteoarthritic and analgesic activity as compare to individual drug patches. Conclusion: The design results revealed that the combination patch exhibited good physicochemical, anti osteoarthritic and analgesic activity for the treatment of osteoarthritis in animals. More plants and their combinations should be explored to get reliable, safe and effective formulations that can compete with synthetic drugs.

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Huang, Chung-Cheng, Chen-Chang Lee, Ching-Jen Wang, Feng-Sheng Wang, Hsuan-Ying Huang, Shu-Hang Ng, Chia-Yi Tseng, and Sheung-Fat Ko. "Effect of Age-Related Cartilage Turnover on Serum C-Telopeptide of Collagen Type II and Osteocalcin Levels in Growing Rabbits with and without Surgically Induced Osteoarthritis." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/284784.

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This study aims to determine the effect of age-related cartilage turnover on the serum C-telopeptide of type II collagen (CTX-II) and osteocalcin (OC) levels in growing rabbits with and without surgically induced osteoarthritis. Twenty-four New Zealand male 3-month-old rabbits were randomized into three operated groups (n= 6 per group, with surgically induced osteroarthritis in the right knee; after blood sampling, the knees were harvested following euthanization at 2, 3, and 6 months after surgery) and a control group (n= 6, blood samples were obtained monthly between 3 and 15 months). Histomorphologically, the medial femoral condyles, particularly the central parts, harbored the most severe osteoarthritic changes among the operated rabbits. The serum levels of CTX-II and OC decreased in the controls from 3 to 11 months and then remained stable. No significant differences in the serum CTX-II and OC levels between the osteoarthritic rabbits and controls were observed. The osteoarthritic-to-normal ratios (ONRs, the ratios of serum CTX-II or OC levels in osteoarthritic rabbits to those of the controls at same ages) enabled an overall assessment of osteoarthritis and age-related cartilage turnover. Elevated CTX-II ONRs were observed in rabbits with mild to advanced osteoarthritis. However, the OC ONRs were unhelpful in assessing osteoarthritic growing rabbits.

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Al-Saadi, Hiba Murtadha, Kok-Yong Chin, Fairus Ahmad, Elvy Suhana Mohd Ramli, Azlan Mohd Arlamsyah, Fadhlullah Zuhair Japar Sidik, Juliana Abdul Hamid, and Ima Nirwana Soelaiman. "Effects of Palm Tocotrienol-Rich Fraction Alone or in Combination with Glucosamine Sulphate on Grip Strength, Cartilage Structure and Joint Remodelling Markers in a Rat Model of Osteoarthritis." Applied Sciences 11, no. 18 (September 15, 2021): 8577. http://dx.doi.org/10.3390/app11188577.

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Background: Osteoarthritis is a degenerative joint disease lacking disease-modifying therapeutic agents. This study aimed to compare the effects of palm tocotrienol-rich fraction (TRF), glucosamine sulphate, and both agents combined in rats with osteoarthritis induced by monosodium iodoacetate (MIA). Methods: Thirty adult male rats were randomized into normal control, and osteoarthritis groups were treated orally daily with vehicle, palm TRF (100 mg/kg), glucosamine sulphate (250 mg/kg), and both agents combined for 4 weeks. Body weight and grip strength were measured weekly. After being sacrificed, the joints and blood were harvested for histology and serum cartilage oligomeric matrix protein (COMP) levels. Results: The body weight of the rats receiving treatment rebounded significantly after an initial reduction (vs osteoarthritic control, p < 0.05). The rats receiving combined treatments showed significantly better grip strength than the osteoarthritic control and individual treatment groups (p < 0.05). The serum COMP level was lower in all the treated groups (vs osteoarthritic control, p < 0.05). Cartilage histology of the treated rats was not significantly improved (vs osteoarthritic control, p > 0.05). Conclusion: The combination of palm TRF and glucosamine sulphate was more effective than individual agents in improving the grip strength of the rats, but the cartilage damage might need more time to heal.

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Більше джерел

Дисертації з теми "Osteoarthritis"

Kiser, Connie Hutley. "Impact of Osteoarthritis Self-Efficacy Toolkit on Adults with Osteoarthritis." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/3617.

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Over 26 million U.S. citizens have a form of arthritis; osteoarthritis (OA) is the most common form. Self-efficacy (SE) is defined as a psychological construct which identifies an individual's confidence when performing a behavior. SE is deemed a vital judge of self-management (SM) in those with OA. The purpose of this evidence-based practice, quality improvement project was to improve SE in OA patients. The identified gap in nursing practice was the lack of SE in OA patients. The project question asked whether a toolkit with information regarding SE in OA can improve SE of management of disease-associated symptoms in adults with OA as evidenced by improved Arthritis Self-Efficacy Scale (ASES) scores pre- to post-program. Concepts and theory used to inform the doctoral project were SE, pain, SM and OA, and Bandura's theory of SE. The sources of evidence were obtained from a variety of peer-reviewed journals related to OA management, and the outcome was measured using the ASES. Thirty-five participants (16 males and 19 females) with a mean age of 62 from a physical medicine and rehabilitation clinic in San Antonio, Texas participated in the project. The National Institute of Arthritis and Musculoskeletal and Skin Disorders 2015 Handout on Health: OA was used as the SE OA toolkit. Mean scores from pre- and post-program were tabulated and compared to determine the outcome. Results showed improved ASES levels by 11.84%. Implications for nursing practice and positive social change include the enhancement of SE levels, which can improve compliance in SM by use of a toolkit and further as policy implementation for OA patients to improve SE and SM abilities.

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Farrán, Díaz-Cano Aina. "Pathophysiology of osteoarthritis." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/456376.

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Osteoarthritis (OA) is a multifactorial disease characterized by a progressive degeneration and eventual failure of the synovial joint functionality. Although it has been traditionally considered as an exclusive disease of the articular cartilage, nowadays it is considered as a whole joint disease. Therefore, the progression of the disease involves articular cartilage degeneration, osteochondral bone sclerosis and synovial membrane hypertrophy. Articular cartilage is a connective tissue resistant to tensile and shears strength that is composed of water (>70%) and a dense extracellular matrix (ECM) that encompasses the unique cellular type of the cartilage, the chondrocytes. The major component of the ECM is the collagen network consisting mainly of type II collagen fibers and type IX and XI collagen macromolecules attached to the surface of the fiber. Non-collagenous components such as GAGs, aggregated proteoglycans (mainly aggrecan) and small leucine rich proteoglycans (SLRP’s) are also binding the collagen fiber. Cartilage is a no innervated and also an avascular tissue, thus gets its nutrients by diffusion from the synovial fluid. Due to this condition, chondrocytes live in a hypoxic environment, and intracellular survival factors, such as hypoxia-inducible factor 1α, are required for maintenance of homeostasis and adaptation to the mechanical environment. Under physiological conditions, the collagen network and proteoglycan content is maintained by the chondrocytes. However, local and systemic risk factors could lead chondrocytes to fail to maintain the ECM and thus the cartilage tissue is progressively degraded. To this point, the three general objectives of this thesis are: 1. Collagenase-3 (COL3) also known as MMP13, is a matrix metalloproteinase abnormally over-expressed in pathological processes. Several COL3 transcripts are expressed in human chondrocytes although their role in OA is still unknown. This study aimed to characterize the presence of two non-canonical COL3 isoforms, named COL3-DEL (deleted form) and COL3-9B (exon 9 added form) in human OA cartilage, and to analyse their proteolytic activity. 2. Opticin (OPTC), a SLRP known to play a role in the assembly of the fibrillar collagens and the structural stability of the extracellular matrix, was previously demonstrated to be produced and degraded in osteoarthritic (OA) human cartilage. Here, we further investigated the OPTC role in OA cartilage by the study of the in vivo effect of OPTC deficiency in mouse model 3. Chondroitin sulfate (CS) is a Symptomatic Slow acting Drug against Osteoarthritis (SySADOA) with anti-inflammatory effects. In this study, we tried to unveil the mechanism of action on osteoarthritic synovial membrane. The general discussion of this thesis is: OA is a heterogeneous disease that encloses multiple phenotypes. In order to develop new diagnostic and prognostic tools and eventually advance in the discovery of successful treatments, clearly defining the different phenotypes of OA is of great importance. In this line, the findings comprised in this thesis reveal two different approaches to identify patient’s subgroups. On one hand, and as described in chapter 1, the presence of a new discovered collagenase-3 (COL3) isoform (COL3-DEL) resulting from a mutation of the canonical COL3, could be used as an indicator of differential extracellular matrix degradation in human articular cartilage. On the other hand, results from chapter 2 suggest that the compositions of the members of SLRP super-family in the human extracellular matrix of the articular cartilage could be applied as a new tool for OA prognosis classification. Finally, the controversy regarding the efficacy of systemic treatment with nutraceuticals – including chondroitin sulfate - may arrive to an end if new tools are used to predict which patients are best suited for a given drug. Importantly, further work remains to be done to understand how to integrate these findings into a final and comprehensive concept that could explain the patient’s heterogeneity and the differential prognosis of OA disease.
L’artrosi (OA) és la malaltia articular més comuna i es caracteritza, principalment, per la destrucció del cartílag articular. El principal paper del cartílag articular és el de suportar les forces de tensió i compressió a les que es troba sotmès i que recau principalment en els seus components: el col·lagen i els proteoglicans. Durant el metabolisme normal del cartílag hi ha un equilibri entre la síntesi i degradació d’aquest components, però a l’artrosi, aquest equilibri es trenca i el metabolisme catabòlic supera l'anabòlic. Durant el desenvolupament de l'OA, els condròcits expressen la proteasa més involucrada en la degradació del cartílag, la MMP-13, que a diferència d’altres MMPs, en humans presenta 3 transcrits diferents. Malauradament, tot i la seva elevada prevalença, l'OA es troba orfe d’una bona tècnica diagnòstica, ja que actualment es realitza per mitjà de tècniques radiològiques que presenten l'inconvenient de que la malaltia només es reflecteix quan l’articulació es troba molt afectada. Actualment, els tractaments farmacològics més utilitzats són analgèsics, AINEs, i els nutracèutics, anomenats SYSADOA per les seves sigles en anglès (Symptomatic Slow Acting Drugs for Osteoarthritis) d’entre els que destaca el sulfat de glucosamina i el condroitin sulfat. Amb aquests antecedents previs, els objectius de la tesis són: 1. Demostrar la presència de 3 isoformes de MMP-13 en humans • Clonació (sistema Bac-to-bac) i purificació de les 3 isoformes en cèl·lules d’insecte (Sf9). • Producció d’anticossos policlonals específics de cada isoforma al Servei de Producció d’Anticossos de la UAB • Cerca de les isoformes en pacients artròsics per WB. • Comprovació de l’activitat de cada isoforma en front a diferents components matricials. 2. Estudiar l'efecte "in vivo" de la deleció del gen de l'Opticina en un model murí d'artrosi. • Confirmar l'expressió de l' OPTC al cartílag articular dels ratolins. • Induïr OA mitjançant el mètode de destabilització del menisc medial (DMM) a ratolins Optc-/- i Optc +/+ de 10 setmanes d'edat. • Analitzar l'efecte de la deficiència de l'OPTC al desenvolupament de l'OA, evaluant la degradació del cartílag i la hipertròfia de la membrana sinovial, deu setmanes després de l'inducció de l'OA per DMM. • Comparar l'expressió de marcadors pro-inflamatoris, catabòlics i anabòlics entre ratolins Optc-/- i Optc+/+. • Analitzar la producció al cartílag de differents SLRPs. • Analitzar l'organització i l'ultraestructura de les fibres de colàgen. 3. Estudiar l'efecte anti-angiogenic del condroitin sulfat en sinoviòcits sota condicions d'hipòxia i d'hipòxia més inflamació. • Mimetitzar condicions inflamatòries i d'hipòxia "in vitro" en sinoviòcits humans. • Estudiar l'expressió i la producció de mediadors angiogènics per sinoviòcits artròsics sota condicions d'hipòxia i inflamació. • Estudiar l'efecte del pretractament del CS en cultius de sinoviòcits humans artròsics • Estudiar l'interacció entre els sinoviòcits artròsics i les cèl·lules endotelials sota hipòxia i inflamació, amb o sense pretractament de CS. L'artrosi és una malaltia que engloba diferents fenotips, però tots comparteixen una sèrie de característiques com la degeneració del cartílag articular, inflamació de la membrana sinovial i esclerosi de l'ós subcondral. Aquestes característiques resulten en un conjunt de símptomes que impedeixen la correcte mobilitat del pacient i creen dolor que pot arribar a ser crònic. Alhora de desenvolupar noves eines de diagnòstic i prognòstic i eventualment avançar en el descobriment de tractaments exitosos, definir clarament els diferents fenotips de l'artrosi és de gran interès. En aquesta línia, els descobriments compresos en aquesta tesis revelen dues possibles maneres d'identificar subgrups de pacients. Per una part, com es descriu al capítol 1, la presència d'una nova isoforma de la colagenasa-3 podria utilitzar-se com a un indicador de diferencies en la degradació matricial del cartíleg humà articular. Per una altre banda, els resultats del capítol 2 suggereixen que la composició dels membres de la famíla de SLRP a la matriu extracel·lular del cartíleg podria aplicar-se com a una nova eina de classificació del prognòstic de la malaltia artròsic. Finalment, la controversia sobre l'eficàcia del tractament amb nutracèutics com el condroitin sulfat podria arribar a solucionar-se si es descobreixen noves eines per predir quins pacients poden respondre millor a un medicament donat. És important tenir en compte que s'ha de continuar investigant per entendre com integrar aquests resultats en un concepte final que pogués explicar l'heterogeneïtat dels pacients i les diferències en el prognòstic de l'artrosi.

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Pengas, Ioannis. "Meniscectomy & osteoarthritis." Thesis, University of Dundee, 2012. https://discovery.dundee.ac.uk/en/studentTheses/967af95f-c162-4870-9b4d-7e0287ebf1a2.

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Meniscal tears are the commonest knee injury and currently are addressed almost exclusively by arthroscopy. Ian Smillie the late Professor of orthopaedics in Tayside, popularised open total meniscectomy worldwide during the 1950s believing that this was necessary for a functioning fibrocartilage replica to completely occupy the ensuing space. The cohort in this study underwent open total meniscectomy under his care prior to their 19th birthday. It was documented in their then records that no other knee pathology was observed during the operation and that the same post operative regime was followed by all. This presents a unique opportunity to evaluate the long term outcomes of open total knee meniscectomy during adolescence and to further investigate biological markers of osteoarthritis 40 years down the line. Fifty-three patients who underwent radiographic evaluation at the 30 year follow-up were further studied at this 40 year review. All surviving and contactable patients were consented prior to assessment and were evaluated clinically; biochemically, radiologically and subjectively once ethical approval and funding were secured. Standardisation of all methods used for examination, radiographic evaluation, sampling of serum and synovial fluid and patient reported outcome measures (PROMs) was achieved by the use of recognised, validated and credible systems as well as good communication between all involved parties. Such examples include the construction of a wooden apparatus standardising the weight bearing skyline views and the need for a smooth and efficient transition between sampling, preparing, storing and transferring the synovial and serum samples. Once all the data were collected, the first striking finding was the proportion of total knee arthroplasties (TKAs) observed as a hard endpoint in this cohort, which suggested a 132 fold increase when compared to their age and geographically matched population data, as per Scottish Arthroplasty Project. It was important to assess if in this cohort the site of meniscectomy demonstrated a significant difference in terms of tibiofemoral joint (TFJ) osteoarthritis, range of motion (ROM) and PROMs as per our chosen scoring systems. As this proved not to be the case, the operated knee was assessed against the non-operated knee where possible and not as per site of meniscectomy. Also the assessed sagittal laxity between the knees did not demonstrate any significant difference and as such was excluded as a confounding factor in terms of initiators of osteoarthritis. A linear correlation was observed between the chosen scoring systems of TFJ osteoarthritis. The calculated relative risk (RR) of developing osteoarthritis (OA) in the operated vs. non-operated knee was calculated for both the KL & Ahlback grading systems with presumed osteoarthritis as =2 for KL & =1 for Ahlback. This was found to be 4.5 & 4.25 respectively. Decreased ROM between the Index and Non-index knees was observed, with the ROM correlating with PROMs and inversely with TFJ OA. In addition the usually under investigated patellofemoral joint was assessed. Patellofemoral joint osteoarthritis was noted in the index knees as opposed to the non-index knees with an observed RR of 1.8 as per presence of osteophytes. There was no significant difference in the degree of patellofemoral joint (PFJ) osteoarthritis between lateral and medial meniscectomies. There was however significant correlations between the joint space narrowing (JSN) and PROMs, TFJ OA and ROM. Worsening results were observed where the PFJ was <5mm. Malalignment was greater in those knees that underwent medial meniscectomy as opposed to either lateral or medial & lateral meniscectomies. Malalignment demonstrated correlation with ROM and TFJ OA. Serum and synovial fluid was processed and analysed with regards to biomarkers of OA in the form of MMP-3 and GAG. Neither serum nor synovial MMP-3 demonstrated any significant correlation with other measured parameters. GAG on the other hand demonstrated a significant difference between the index and non-index knee as well as a positive correlation to IKDC and an inverse correlation with TFJ OA. Although this is suggesting that synovial GAG as a biomarker for OA may indicate progression of disease and symptoms, the wider spread of values questions this. Two different PROMs were utilised to assess this cohort. Interestingly the KOOS demonstrated that in all its 5 parameters the cohort was symptomatic. Correlations were observed between the KOOS ADL & Sport as well as IKDC with TFJ OA. This is currently the longest follow-up of open total meniscectomy in adolescence worldwide. A >4 fold increased risk of osteoarthritis in the operated knee as compared to the non-operated knee was demonstrated and possibly a 132 fold increase in TKA as compared to their aged matched geographical peers.

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Vanhook, Patricia M., Lynne M. Dunphy, T. South, L. Plank, and C. Luskin. "Osteoarthritis and Osteoporosis." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7411.

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Book Summary: Serves the needs of advanced practice nurses because it’s written by nurse practitioners for nurse practitioners, in collaboration with a physician. Organizes content around the Circle of Caring framework for nursing-based knowledge and holistic care. Explores complementary and alternative treatments for each disorder. Covers the broadest range of human disease and disorders using a systems-based approach, presenting both common complaints and common problems to help students narrow down the possible differentials to the most likely diagnosis. Considers interactions of pharmaceuticals with alternative medications and nutraceuticals. Features coverage of pathophysiology and diagnostic reasoning as well as up-to-date guidance on laboratory and diagnostic tests. Emphasizes evidence-based practice with information on evidence levels and more references to primary studies. Integrates discussions of health policy and primary care throughout the text.

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Lim, Keith K. T. "Osteoarthritis of the hand." Thesis, University of Bristol, 1997. http://hdl.handle.net/1983/3282d842-4e4d-4db9-9dd4-1542cf8aefc9.

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Dahlberg, Leif. "Post-traumatic arthrosis cartilage markers in joint fluid for the identification of patients at risk /." Lund : Dept. of Orthopaedics, University Hospital, Lund University, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39854555.html.

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Morley, Gavin W. "Gene hunting in primary osteoarthritis." Thesis, University of Oxford, 2004. https://ora.ox.ac.uk/objects/uuid:1529aa12-2d57-48fd-8cb9-a5bab0291116.

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Osteoarthritis (OA) is a common, disabling disease of the elderly. It is uncommon in individuals under 45 years of age, and prevalence is higher in females than males. OA is characterised by focal cartilage loss accompanied by osteophytes, sclerosis and often some inflammatory response. A significant genetic component to OA has been demonstrated by twin-pair, sibling risk and segregation studies. Our group previously carried out a two-stage genome-wide linkage scan and identified six chromosomal regions as potentially harbouring OA susceptibility genes. The aim of this project was to examine three of these linkage regions, one on chromosome 4 and two on chromosome 16, in more detail in order to further localise and determine the identity of the OA susceptibility gene(s) within these regions. Initially the three regions were linkage mapped using a staged approach. Linkage mapping of the region on chromosome 4q identified a region showing evidence of linkage to female hip OA with a multipoint LOD (MLS) score of 3.1. For chromosome 16 linkage mapping identified two regions with MLS of 1.7 and 1.9 respectively. The first region was restricted to families with female siblings concordant for hip OA while the second is accounted for by families with affected female siblings. The ADAMTS3 gene was identified as a strong candidate gene within the linkage region on chromosome 4 as a result of its role in procollagen processing. SNPs within the gene were identified and typed in cohorts of cases and controls. There was no evidence for an association with any of these SNPs and OA disease. Within the first linkage region on chromosome 16 the IL4R gene was identified as a strong candidate gene as a result of its proposed role in the normal response of chondrocytes to mechanotransduction. Again SNPs within the gene were identified and typed. Four SNPs show evidence of association with OA and for three of these there is evidence for a relationship between genetic variation and evidence for linkage. It appears that there is a dosage effect with at least two copies of different variant alleles being necessary to increase OA disease susceptibility.

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Palmer, Antony. "Aspects of early hip osteoarthritis." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:f2d4b3b0-24b4-4053-86fe-97637cebf37d.

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Osteoarthritis develops secondary to the action of hostile biomechanics upon susceptible cartilage. Cam morphology describes a loss of concavity at the femoral head-neck junction resulting in femoral impaction against the acetabular rim within a functional range of movement. This impaction is termed femoroacetabular impingement and can result in pain and cause damage to adjacent articular cartilage that progresses to osteoarthritis. Cam morphology is a target for joint preservation strategies. The first study in this thesis compares hip development in academy football players with controls from local schools. The results provide strong evidence that cam morphology can develop in response to intense sporting activity during adolescence. At present, it is not possible to recommend activity modification as the cardiovascular benefits of exercise are likely to outweigh potentially detrimental effects on hip morphology. Nevertheless, individuals participating in high-level sports during youth may represent a high risk cohort for osteoarthritis warranting surveillance. Diagnostic tools currently available only allow identification of late joint degeneration when disease is irreversible. Advances in the field of disease biomarkers may overcome this challenge. The second study of this thesis explored the prognostic value of compositional MRI. Baseline delayed gadolinium-enhanced MRI of cartilage was able to predict the development of radiographic hip osteoarthritis in asymptomatic individuals within five years. As well as identifying individuals who are likely to benefit from intervention, compositional MRI may allow the evaluation of treatment efficacy within short timeframes. A number of interventions aimed at joint preservation are under investigation for treating cam morphology femoroacetabular impingement. Arthroscopic surgery is increasingly performed to restore the concavity at the femoral head-neck junction and prevent impaction against the acetabular rim. A feasibility study was performed for a proposed randomised controlled study comparing operative and non-operative treatment. The study protocol was developed for the 'Femoroacetabular Impingement Trial' (FAIT).

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Ratzlaff, Charles R. "Lifetime physical activity and osteoarthritis." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/36735.

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Introduction: The overall goal of this thesis is to improve understanding of physical activity (PA), one of the most important, modifiable but controversial risk factors in osteoarthritis (OA). OA is the major public health problem in musculoskeletal medicine and leading cause of physical disability in older adults. The ultimate purpose is to provide evidence to inform OA prevention strategies, something not currently available. Objectives: 1) To construct and describe lifetime trajectories of hip and knee joint force from physical activity in a large Canadian sample; 2) To validate self-report measures of medically-diagnosed OA and novel measures of joint vulnerability against clinical criteria; 3) To evaluate the relationship of lifetime joint force and hip and knee OA. Methods: PA data were collected online from 4,269 subjects via a validated PA survey in a national population-based cohort from 2005 to 2007 and subjects ranked and lifetime trajectories plotted in terms of the ‘cumulative peak force index’, a novel joint force measure. Validation studies were conducted in a sub-sample. Population-based multivariable studies examining the relationship between joint force and incident hip and prevalent knee OA were conducted. Results: 1) Overall women had slightly higher lifetime PA-related force then men. Six percent of subjects developed hip OA and seven percent knee OA during follow up. There was no risk from sport/recreational activity. Very high levels of total lifetime force (hip and knee), occupational force in men (knee) and household-related force in women (knee) were associated with an approximate 2-fold increase in risk of OA, as was previous joint injury (5-fold increase hip, 3-fold knee). At the knee, lower limb malalignment but not joint hypermobility, was associated with knee OA. Higher coordination was protective. Conclusions: Taken collectively, the results show that lifelong physical activity-related joint force is generally safe for the hip and knee, and the promotion of exercise as a major public health initiative should continue without concern for increased rates of OA. Very high levels of occupational force in men and household force in women were risk factors for knee OA. Joint injury, lower limb malalignment and lower coordination were associated with OA.

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Chard, Jiri Alexander. "Investigation of services for osteoarthritis." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437311.

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Книги з теми "Osteoarthritis"

Grifka, Joachim, and Darrell J. Ogilvie-Harris, eds. Osteoarthritis. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-87752-0.

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Schumacher, H. Ralph, ed. Osteoarthritis. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73878-4.

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Reginster, J. Y., J. P. Pelletier, J. Martel-Pelletier, Y. Henrotin, and L. Crasborn. Osteoarthritis. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-60026-5.

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Kapoor, Mohit, and Nizar N. Mahomed, eds. Osteoarthritis. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-19560-5.

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D, Brandt Kenneth, Doherty M. M. D, and Lohmander Stefan, eds. Osteoarthritis. Oxford: Oxford University Press, 1998.

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Don, Brown. Osteoarthritis. Seattle, WA: Natural Product Research Consultants, 1997.

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D, Brandt Kenneth, Doherty M. M. D, and Lohmander Stefan, eds. Osteoarthritis. Oxford: Oxford University Press, 2003.

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A, Johnston Spencer, ed. Osteoarthritis. Philadelphia: W.B. Saunders Co., 1997.

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National Institute of Arthritis and Musculoskeletal and Skin Diseases (U.S.), ed. Osteoarthritis. Bethesda, Md: National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, 1999.

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P, Stitik Todd, ed. Osteoarthritis. Philadelphia: Hanley & Belfus, Inc., 2001.

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Частини книг з теми "Osteoarthritis"

Berger, Rainer. "Welcome Address." In Osteoarthritis, 1–2. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73878-4_1.

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Bach, G. L. "Osteoarthrosis (Osteoarthritis) — Opening Remarks." In Osteoarthritis, 3–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73878-4_2.

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Schumacher, H. R. "Osteoarthritis: State of the Art." In Osteoarthritis, 5–10. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73878-4_3.

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Fassbender, H. G. "Interaction Between Cartilage Metabolism and Inflammation." In Osteoarthritis, 11–13. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73878-4_4.

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Zimmermann, M. "Basic Mechanisms of Pain and Pain Therapy Related to Osteoarthritis and Other Disorders of the Musculoskeletal System." In Osteoarthritis, 14–28. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73878-4_5.

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Müller-Fassbender, H. "Course of Degenerative Joint Diseases." In Osteoarthritis, 29–37. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73878-4_6.

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Moskowitz, R. W. "Therapeutic Interventions in the Treatment of Acute and Chronic Pain in Osteoarthrosis." In Osteoarthritis, 38–46. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73878-4_7.

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Wildner, M., and O. Sangha. "Epidemiologic and Economic Aspects of Osteoarthrosis." In Osteoarthritis, 1–8. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-87752-0_1.

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Nehrer, S., and M. Spector. "Tissue Engineering in Cartilage Repair: In Vitro and In Vivo Experiments on Cell-Seeded Collagen Matrices." In Osteoarthritis, 111–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-87752-0_10.

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Brittberg, M. "Autologous Chondrocyte Grafting for the Treatment of Cartilage Defects." In Osteoarthritis, 121–28. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-87752-0_11.

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Тези доповідей конференцій з теми "Osteoarthritis"

Galván-Tejada, Jorge I., José M. Celaya-Padilla, Victor Treviño, and José G. Tamez-Peña. "Knee osteoarthritis image registration: data from the Osteoarthritis Initiative." In SPIE Medical Imaging, edited by Lubomir M. Hadjiiski and Georgia D. Tourassi. SPIE, 2015. http://dx.doi.org/10.1117/12.2082426.

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de Vries, Charlotte, and Matthew B. Parkinson. "Identifying Glenoid Geometries Through Radial Basis Functions for Implant Design." In ASME 2014 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/detc2014-35478.

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Total Shoulder Arthroplasty is performed on patients to restore range of motion of the shoulder and decrease pain caused by osteoarthritis at the glenohumeral joint. The glenohumeral joint is a slightly unstable ball and socket joint, where muscles hold the humerus in contact with the glenoid, located on the scapula. Improper sizing or alignment of the implant can cause the surgery to fail to restore mobility to the shoulder or only restore mobility for a limited time. Additionally, placement of the glenoid implant on the scapula is complicated by the limited view available during surgery and the deformation of the glenoid caused by osteoarthritis. Implant designs must take into account the large amount of variability present in both intact and osteoarthritic joints. The purpose of this research is to provide a morphable glenoid representation for the scapula to assist with preoperative planning and implant design. CT scans of healthy and osteoarthritic glenoids were provided by Hershey Medical Center for this study. Principal component analysis and radial basis functions are used to represent a range of potential glenoid geometries, both with and without osteoarthritis. This parametric model can be used to guide the design and sizing of implants. This approach should be extensible to the modeling of other bony surfaces, which can improve both implant design and surgical procedure.

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Eilert, Rebecca, Marc Hassenzahl, and Mirijam Buhr. "The Osteoarthritis-Journey." In DIS '20: Designing Interactive Systems Conference 2020. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3393914.3395854.

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Oreiro, Natividad, Ignacio Rego-Perez, Sara Relaño-Fernandez, Maria Teresa Silva, Paula Ramos-Louro, Alejandro Durán-Sotuela, Sonia Pertega, and Francisco J. Blanco. "OP0173 EROSIVE HAND OSTEOARTHRITIS ASSOCIATES WITH LOW OCCURRENCE OF KNEE OSTEOARTHRITIS." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.4647.

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Vincent, Tonia, and Susanne Kammerer. "New treatments in osteoarthritis." In EULAR 2022 Congress, edited by Tonia Vincent and Dennis McGonagle. Baarn, the Netherlands: Medicom Medical Publishers, 2022. http://dx.doi.org/10.55788/0b64d809.

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Handoyo, Rudy. "Osteoarthritis of the Hip." In The 11th National Congress and The 18th Annual Scientific Meeting of Indonesian Physical Medicine and Rehabilitation Association. SCITEPRESS - Science and Technology Publications, 2019. http://dx.doi.org/10.5220/0009061900370043.

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Galvan-Tejada, Jorge I., Victor Trevino, Jose M. Celaya-Padilla, and Jose G. Tamez-Pena. "Knee Osteoarthritis pain prediction from X-ray imaging: Data from Osteoarthritis Initiative." In 2014 International Conference on Electronics, Communications and Computers (CONIELECOMP). IEEE, 2014. http://dx.doi.org/10.1109/conielecomp.2014.6808590.

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Luo, Y., Y. He, AS Siebuhr, S. Hoielt, D. Felson, M. Karsdal, and A.-C. Bay-Jensen. "SAT0554 Investigation of selected biochemical markers in knee osteoarthritis: the framingham osteoarthritis cohort." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.1744.

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Hapsari, Laras, Widjajalaksmi Kusumaningsih, and Tirza Z. Tamin. "Gait Analysis and Falls between Persons with Knee Osteoarthritis and Non-Knee Osteoarthritis." In The 11th National Congress and The 18th Annual Scientific Meeting of Indonesian Physical Medicine and Rehabilitation Association. SCITEPRESS - Science and Technology Publications, 2019. http://dx.doi.org/10.5220/0009088902480251.

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Kan, Kanis W. C., Emma Pickwell-MacPherson, and W. H. Cheung. "Terahertz pulsed imaging of osteoarthritis." In 2008 5th International Summer School and Symposium on Medical Devices and Biosensors. IEEE, 2008. http://dx.doi.org/10.1109/issmdbs.2008.4575055.

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Звіти організацій з теми "Osteoarthritis"

Weidong, Zhang, Zhenhai Cui, Liquan Sha, and wenhai Zhao. Tuina for osteoarthritis : a protocol for systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2022. http://dx.doi.org/10.37766/inplasy2022.10.0122.

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Review question / Objective: As a traditional Chinese medicine technique, massage can treat osteoarthritis. The aim of this systematic review protocol was to evaluate the value of the efficacy and safety of tuina in the treatment of osteoarthritis. Condition being studied: Osteoarthritis (OA) is a particularly common chronic degenerative disease that not only severely affects patients' joint function and quality of life, but also causes serious health problems worldwide. Tuina, a traditional Chinese medicine technique, has been widely used to treat OA in Asian countries such as China and Thailand, but the evidence for its effectiveness is unclear.

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Huang, Zeling, Xiao Mao, Junming Chen, Junjun He, Shanni Shi, Miao Gui, Hongjian Gao, and Zhenqiang Hong. Sinomenine hydrochloride injection for knee osteoarthritis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2021. http://dx.doi.org/10.37766/inplasy2021.11.0057.

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Review question / Objective: At present, many clinical studies have been reported on the treatment of KOA by injecting sinomenine hydrochloride into the knee cavity. However, no systematic evaluation has been published on this issue, and it is not clear whether sinomenine hydrochloride injection is effective and safe in the treatment of KOA.Therefore, it is important to conduct systematic evaluation to obtain relatively convincing conclusions as to whether sinomenine hydrochloride injection can be a good choice as a complementary and alternative drug (CAM) for KOA. Condition being studied: The RCTs are eligible, whether or not the blind method is specifically described. There are no restrictions on languages. Moreover, systemic evaluation, review literature and the full article cannot be obtained will be excluded.

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Li, Jia, Yuan Liu, Jing Zhang, and Mingxing Yuan. Neuroimaging studies of acupuncture on knee osteoarthritis: a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0110.

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Review question / Objective: This study was conducted in order to investigate the study design and main outcomes of acupuncture neuroimaging studies on knee osteoarthritis (KOA),and reveal the potential mechanism of the pain-relieving effect of acupuncture on knee osteoarthritis. Condition being studied: Knee osteoarthritis is a very common disease that seriously affects people's quality of life. Acupuncture, as an effective treatment option, can achieve pain relief and treat the disease, but the mechanism of acupuncture analgesia is still unclear to us. Therefore, we set certain criteria to include eligible clinical trials to reveal its principles.

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Taylor, Nathan L., and Robert Strauch. Suture Anchor Arthroplasty for Thumb Carpometacarpal Osteoarthritis. Fort Belvoir, VA: Defense Technical Information Center, July 2004. http://dx.doi.org/10.21236/ada424777.

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Xu, Zhiteng, and Renbin Li. A systematic review and meta-analysis of outcomes following unicompartmental knee arthroplasty versus total knee arthroplasty for unicondylar knee osteoarthritis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2023. http://dx.doi.org/10.37766/inplasy2023.3.0003.

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Review question / Objective: To conduct a systematic review and meta-analysis of randomized controlled trials comparing outcomes following unicompartmental knee arthroplasty versus total knee arthroplasty for patients with unicondylar knee osteoarthritis. Condition being studied: Knee osteoarthritis is a common disease in elderly population and its treatment strategies consist of non-operative treatment and surgery. Arthroplasty is a main surgery for this condition, while the optimal selection between unicompartmental knee arthroplasty and total knee arthroplasty remains debatable. We aim to collect RCTs comparing these two techniques in treatment of knee osteoarthritis and make a meta-analysis in order to provide high level of evidence for future decision-making for this issue.

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Guryanova, E. A., Yu V. Polyakova, and M. A. Matveeva. SHOCK WAVE THERAPY FOR OSTEOARTHRITIS OF THE KNEE. Publishing house FSAEI of HE "KFU im. IN AND. Vernadsky, 2019. http://dx.doi.org/10.18411/2413-0478-2019-2-57-61.

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Price, Chrisopher. Bisphosphonates in the Prevention of Post-Traumatic Osteoarthritis. Fort Belvoir, VA: Defense Technical Information Center, July 2014. http://dx.doi.org/10.21236/ada615280.

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Shen, Cimin, Na Li, Chen Bin, Wu Jinzuan, Wu Zhining, Hua Dangyun, Wang Lu, et al. Thermotherapy for knee osteoarthritis: a systematic review protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2021. http://dx.doi.org/10.37766/inplasy2021.4.0038.

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Polyakova, Y., L. Seewordova, Y. Akhverdyan, E. Papichev, and B. Zavodovsky. LOW-LEVEL INFLAMMATION AND COMORBID PATHOLOGY IN OSTEOARTHRITIS. DOI CODE, 2021. http://dx.doi.org/10.18411/wco-iof-esceo-2021-498-499.

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Newberry, Sydne J., John FitzGerald, and Nelson F. SooHoo. Treatment of Osteoarthritis of the Knee: An Update Review. Agency for Healthcare Research and Quality (AHRQ), May 2017. http://dx.doi.org/10.23970/ahrqepccer190.

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