Готові списки джерел за темами / Organotin compounds

Добірка наукової літератури з теми "Organotin compounds"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 18 травня 2024

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Статті в журналах з теми "Organotin compounds":

White, Jane S., John M. Tobin, and Joseph J. Cooney. "Organotin compounds and their interactions with microoganisms." Canadian Journal of Microbiology 45, no. 7 (August 1, 1999): 541–54. http://dx.doi.org/10.1139/w99-048.

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Organotin compounds are ubiquitous in the environment. The general order of toxicity to microorganisms increases with the number and chain length of organic groups bonded to the tin atom. Tetraorganotins and inorganic tin have little toxicity. Because of their lipophilicity, organotins are regarded as membrane active. There is evidence that the site of action of organotins may be both at the cytoplasmic membrane and intracellular level. Consequently, it is not known whether cell surface adsorption or accumulation within the cell, or both is a prerequisite for toxicity. Biosorption studies on a fungus, cyanobacteria, and microalgae indicates that cell surface binding alone occurred in these organisms, while studies on the effects of TBT (tributyltin) on certain microbial enzymes indicated that in some bacteria TBT can interact with cytosolic enzymes. Microorganism-organotin interactions are influenced by environmental conditions. In aquatic systems, both pH and salinity can determine organotin speciation and therefore reactivity. These environmental factors may also alter selectivity for resistant microorganisms in polluted systems. Tin-resistant microorganisms have been identified, and resistance can be either plasmid or chromosomally mediated. In one TBT-resistant organism, an Altermonas sp., an efflux system was suggested as the resistance mechanism. Biotransformation of organotin compounds by debutylation or methylation has been observed. These reactions may influence the toxicity, mobility, and environmental fate of organotin compounds.Key words: inorganic tin, organotins, microorganisms, organotin resistance, biosorption, biotransformation.

Podestá, J. C., A. B. Chopa, A. D. Ayala, and L. C. Koll. "Organotin compounds." Journal of Organometallic Chemistry 333, no. 1 (October 1987): 25–36. http://dx.doi.org/10.1016/s0022-328x(00)99028-4.

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Ayala, A. D., N. Giagante, J. C. Podestá, and W. P. Neumann. "Organotin compounds." Journal of Organometallic Chemistry 340, no. 3 (February 1988): 317–29. http://dx.doi.org/10.1016/0022-328x(88)80025-1.

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Podestá, Julio C., Alicia D. Ayala, Alicia B. Chopa, and Nelda N. Giagante. "Organotin compounds." Journal of Organometallic Chemistry 364, no. 1-2 (March 1989): 39–55. http://dx.doi.org/10.1016/0022-328x(89)85329-x.

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Martin, F., FM Corrigan, Ofx Donard, J. Kelly, Jao Besson, and DF Horrobin. "Organotin compounds in trimethyltin-treated rats and in human brain in Alzheimer's Disease." Human & Experimental Toxicology 16, no. 9 (September 1997): 512–15. http://dx.doi.org/10.1177/096032719701600906.

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As blood tin concentrations are elevated in Alzheimer's disease and as some low molecular weight organotin compounds are neurotoxic, we have attempted to detect organotins in brain in Alzheimer's Disease. First we measured the concentration of trimethyltin (TMT) in the brains of rats which had been exposed to memory- impairing concentrations of TMT and, as the method of linking hydride generation, cryogenic trapping, gas chromatographic separation and atomic absorption spec trophotometric detection permitted the measurements of organotin compounds when the total tin was greater than 0.2 nanograms, we applied these techniques to human brain tissue, some of which showed neuropathological evidence of Alzheimer's Disease. No low molecular weight organotin compounds were detected in the human brain tissue, but it is possible that tin may be complexed with large organic molecules, the hydrides of which would not be volatile, but which could be identified by liquid chromatography.

Terraza, V. Fabricio, Darío C. Gerbino, and Julio C. Podestá. "Stereoselective Hydrostannation of Diacrylate and Dimethacrylate Esters of Galactaric Acid Derivatives: Cyclohydrostannation vs. Diaddition." Proceedings 9, no. 1 (November 14, 2018): 55. http://dx.doi.org/10.3390/ecsoc-22-05688.

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This paper reports a study on the free radical hydrostannation of ((4S,4′R,5R,5′S)-2,2,2′,2′-tetramethyl-[4,4′-bi(1,3-dioxolane)]-5,5′-diyl)bis(diphenyl methylene) diacrylate (1) and dimethacrylate (2) with triorganotin hydrides, R3SnH (R = Me, n-Bu, Ph). Preliminary investigations show that these reactions could lead to mixtures of products of cyclohydrostannation and/or mono- or diaddition according to the organotin hydrides employed and the reaction conditions used. The addition of Me3SnH to 1 afforded a mixture of three organotin compounds from which the pure new 13-membered macrodiolide 3 (48%) was obtained. The other two organotins could not be separated. The addition of n-Bu3SnH to diester 1 led to a mixture of two organotins, the one in major proportion (91%) being the product of diaddition 7. The minor product 6a (9%) could not be isolated pure. The hydrostannation of 1 with Ph3SnH led to one organotin: The product of diaddition 8. The hydrostannation of the dimethacrylate 2 with the organotin hydrides R3SnH (R = Me, n-Bu, Ph) under the same reaction conditions, led in the three cases to mixtures containing mainly diaddition products, and no cyclization products were detected. Some physical characteristics of the new compounds including selected values of 1H, 13C, and 119Sn NMRs are included.

Cheng, Shuming, and Jing Yang. "A Theoretical Study of Organotin Binding in Aromatase." International Journal of Molecular Sciences 24, no. 10 (May 18, 2023): 8954. http://dx.doi.org/10.3390/ijms24108954.

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The widely used organotin compounds are notorious for their acute toxicity. Experiments revealed that organotin might cause reproductive toxicity by reversibly inhibiting animal aromatase functioning. However, the inhibition mechanism is obscure, especially at the molecular level. Compared to experimental methods, theoretical approaches via computational simulations can help to gain a microscopic view of the mechanism. Here, in an initial attempt to uncover the mechanism, we combined molecular docking and classical molecular dynamics to investigate the binding between organotins and aromatase. The energetics analysis indicated that the van der Waals interaction is the primary driving force of binding the organic tail of organotin and the aromatase center. The hydrogen bond linkage trajectory analysis revealed that water plays a significant role in linking the ligand–water–protein triangle network. As an initial step in studying the mechanism of organotin inhibiting aromatase, this work provides an in-depth understanding of the binding mechanism of organotin. Further, our study will help to develop effective and environmentally friendly methods to treat animals that have already been contaminated by organotin, as well as sustainable solutions for organotin degradation.

Fent, Karl. "Ecotoxicology of Organotin Compounds." Critical Reviews in Toxicology 26, no. 1 (January 1996): 3–117. http://dx.doi.org/10.3109/10408449609089891.

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Fait, Antonella, Adalberto Ferioli, and Franco Barbieri. "Chapter 11 Organotin compounds." Toxicology 91, no. 1 (June 1994): 77–82. http://dx.doi.org/10.1016/0300-483x(94)90244-5.

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Appel, Klaus E. "Organotin Compounds: Toxicokinetic Aspects." Drug Metabolism Reviews 36, no. 3-4 (January 2004): 763–86. http://dx.doi.org/10.1081/dmr-200033490.

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Дисертації з теми "Organotin compounds":

Clarke, David John. "Organotin compounds for catalysis." Title page, abstract and contents only, 2001. http://web4.library.adelaide.edu.au/theses/09SM/09smc5974.pdf.

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Hill, Michael Stephen. "Organotin tetrazoles and related compounds." Thesis, University of Bath, 1994. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240694.

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Kuan, Fong Sheen, and mikewood@deakin edu au. "Organotin-Oxo Clusters." Deakin University. School of biological and chemical sciences, 2002. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20051125.084244.

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This thesis reports on the development and expansion of reliable synthetic di-and multi-tin precursors for the assembly of oligomeric organotin-oxo compounds in which the shape, dimension and tin nuclearity can be controlled. The reaction of polymeric diorganotin oxides, (R2SnO)m (R = Me, Et, n-Bu, n-Oct, c-Hex, i-Pr, Ph), with saturated aqueous NH4X solutions (X = F, Cl, Br, I, OAc) in refluxing 1,4-dioxane afforded in high yields dimeric tetraorganodistannoxanes, [R2(X)SnOSn(X)R2]2, and in a few cases diorganotin dihalides or diacetates, R2SnX2. This method appears to be particularly good for the synthesis of halogenated tetraorganodistannoxanes but a less suitable method for the preparation of dicarboxylato tetraorganodistannoxanes. Identification of [R2(OH)SnOSn(X)R2]2 (R = n-Bu; X = Cl, Br) and [R2(OH)SnOSn(X)R2][R2(X)SnOSn(X)R2] suggest a serial substitution mechanism starting from [R2(OH)SnOSn(OH)R2]2. A series of α, ω -bis(triphenylstannyl)alkanes, [Ph3Sn]2(CH2)n (n = 3-8, 10, 12) and some of their derivatives were synthesised and characterised. These α, ω-bis(triphenylstannyl)alkanes, [Ph3Sn]2(CH2)n were converted to the corresponding halides [R(Cl)2Sn]2(CH2)n (R = CH2SiMe3) and subsequently to the polymeric oxides {[R(0)Sn]2(CH2)n}m. Reaction of {[R(O)Sn]2(CH2)n}m with [R(Cl)2Sn]2(CH2)n. (n = 3, n' = 4 and n = 4, n' = 3) in toluene at 100°C results in a mixture of symmetric and asymmetric double ladders, where different spacer chain lengths (n and n') provide the source of asymmetry. The coexistence at high temperature of separate 119Sn NMR signals belonging to symmetric and asymmetric double ladders suggests an equilibrium that is slow on the 119Sn NMR time scale and the position of which is temperature dependent. However, 119Sn NMR spectroscopic experiments of {[R(0)Sn]2(CH2)3}m with [R(Cl)2Sn]2(CH2)n for longer spacers (n - 5, 6, 8, 10, 12) reveal that molecular self-assembly of symmetric spacer-bridged di-tin precursors of equal chain length is preferred over asymmetric species. An ether-bridged di-tin tetrachloride [R(Cl)2Sn(CH2)3]2O (R = CH2SiMe3) and its corresponding polymeric oxide {[R(O)Sn(CH2)3]2O}m were synthesised and characterised. Reaction of [R(Cl)2Sn(CH2)3]2O with {[R(O)Sn(CH2)3]2O}m results in a unique functionalised double ladder {{[RSn(Cl)](CH2)3O(CH2)3[RSn(Cl)]}O}4 whose structure in the solid state was determined by X-ray analysis. Identification of tetrameric functionalised double ladder as well as dimeric and monomeric species suggest the existence of an equilibrium in solution. The feasibility of the functionalised double ladder to form host-guest complexes with a variety of metal cations is investigated using electrospray mass spectrometry (ESMS). Evidence for such complexes is found only for sodium cations. The reaction between {[R(O)Sn]2(CH2)n}m (n = 3, 4, 8, 10) and triflic acid is described. The initial formed products [RSn(CH2)nSnR](OTf)4 are easily hydrolysed. For n = 3, self-assembly leads to a discrete double ladder type structure, {{[RSn(OH)](CH2)3[RSn(H2O)]}O}44OTf, which is the first example of a cationic double ladder. For n ≥ 3, hydrolysis gives polymeric products, as demonstrated by the crystal structure of {[(H2O)(OH)RSn]2(CH2)4-2OTf2H2O}m. Two spacer-bridged terra-tin octachlorides [R(Cl)2Sn(CH2)3Sn(Cl)2]2(CH2)n (R = CH2SiMes; n = 1, 8) and their corresponding polymeric oxides {[R(O)Sn(CH2)3Sn(O)]2(CH2)n}m were successfully synthesised and characterised. Attempts were made to synthesise quadruple ladders from these precursors. Reactions of [R(Cl)2Sn(CH2)3Sn(Cl)2]2CH2 with {[R(O)Sn(CH2)3Sn(O)]2CH2}m or (Y-Bu2SnO)3 result in, mostly insoluble, amorphous solids. Reactions of [R(Cl)2Sn(CH2)3Sn(Cl)2]2(CH2)8 with {[R(O)Sn(CH2)3Sn(O)]2(CH2)8}m or (t-Bu2SnO)s result in new tin-containing species which are presumably oligomeric. The synthesis of a series of alkyl-bridged di-tin hexacarboxylates [(RCO2)3Sn]2(CH2)n (n = 3, 4; R = Ph, c-C6H11, CH3, C1CH2) is also reported. The hydrolysis of these compounds is facile and complex. There appears to be no correlation between spacer chain length and hydrolysis product. However, the conjugate acid strength of the carboxylate does appear to be important. In general only insoluble amorphous polymeric organotin-oxo compounds were obtained.

Al-Rawi, Mustafa. "Halogenation of sterically hindered organotin compounds." Thesis, University of Sussex, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310661.

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Chatterjee, Debesh Kumar. "Arylazo phenoxy derivatives of organotin compounds." Thesis, University of North Bengal, 1990. http://hdl.handle.net/123456789/757.

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Ross, Jennifer Nicola. "Alkoxy- substituted aryl- and benzyl- organotin compounds." Thesis, University of Aberdeen, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324880.

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New organotin compounds containing alkoxy- functionalities have been prepared. The methods of preparation of the tetraorganotin species have involved three routes. Hydrostannation reactions using triphenyltin hydride have resulted in the synthesis of triphenyltin derivatives of a series of alkoxy- substituted allyl ethers. The addition of tin IV chloride, diphenyltin dichloride and phenyltin trichloride to alkoxy- substituted aryl- and benzyl- Grignard reagents have also been successful. Alkoxy- substituted benzyltin compounds have been prepared by following an alternative preparation of benzylmagnesium halides from that commonly used to prepare Grignard reagents. Nucleophilic substitution of (iodomethyl)triphenyltin by a novel ligand has been effective. The structures of the products have been investigated by ¹H, ¹³C and ¹¹⁹Sn nmr. Single crystal X-ray diffraction studies have led to the determination of the crystal structures of tetra-2-anisyltin, tetrakis-(2-methoxybenzyl)tin and N,N'-bis(5-triphenylstannoxymethyl-2-phenyl-1,3-dioxan-5-yl)ethanediamide. Selective tin-carbon bond cleavage has been effected by the use of iodine and bromine to give rise to mono- and dihalo- organotin compounds and the crystal structures of tri-2-anisyltin iodide and di-2-anisyltin dibromide have been elucidated by X-ray crystallography. Chloro(3-ethoxypropyl)diphenyltin has been synthesised directly from diphenyltin dichloride and has been found to contain a penta-co-ordinate tin centre with a four membered chelate ring as a result of intramolecular tin-oxygen co-ordination. Other tin-carbon bond cleavage reactions by halogens have been studied by ¹H and ¹¹⁹Sn nmr and GLC and the results discussed.

Deb, Chaitali. "Preparation and reactions of some organotin compounds : applications to organic synthesis." Thesis, University of North Bengal, 1993. http://hdl.handle.net/123456789/759.

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Doidge-Harrison, Solange Maria Silva Veloso. "X-ray and spectroscopic studies of organotin compounds." Thesis, Robert Gordon University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304984.

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O'Loughlin, Edward John. "Association of organotin compounds with aquatic humic substances /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487946776023338.

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Baguley, Paul A. "Search for practical alternatives to organotin hydrides." Thesis, University of St Andrews, 1998. http://hdl.handle.net/10023/15419.

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A summary of the tin hydride method of generating radicals in organic synthesis is presented, followed by illustrative examples of other methods available for mediating radical reactions, with a particular emphasis on recent developments. This is followed by four chapters describing our efforts to introduce alternative methods for generating radicals. A range of l-alkylcyclohexa-2,5-diene-l-carboxylic acids have been prepared by Birch reduction-alkylation methodology and shown to generate the corresponding alkyl radical by thermal initiation with dibenzoyl peroxide. The 1-benzyl, cyclopentyl and t-butyl precursors (17,15, and 16 respectively), acted as sources of radicals which were trapped with cyclohexenone to give the corresponding 3-alkylcyclohexanone adducts in yields of 52%, 30% and 25% respectively. Addition products were also observed when acrylonitrile and vinyl benzoate were employed as the radical traps. 1-[2-(Cylohex-2-enyloxy)ethyl]cyclohexa-2,5-diene-l-carboxylic acid 32 and l-[2-(6,6- dimethylbicyclo[3.1. l]hept-2-en-2-ylmethoxy)ethyl]cyclohexa-2,5-diene- 1-carboxyhc acid 33 are new compounds which were prepared in four straightforward steps from cyclohexene and β-pinene respectively. The route leading to acid 32 involved the preparation of four new compounds and three new compounds were prepared during the synthesis of acid 33. When refluxed in benzene in the presence of dibenzoyl peroxide, carboxylic acid 32 generated a primary alkyl radical which cyclised to yield 7- oxabicyclo[4.3.0]-nonane in 55% yield. The tin-mediated cyclisation of 3-(2'- iodoethoxy)cyclohexene 36 yielded the same compound in 60% yield, in addition to 3- ethoxycyclohexene (12%). Similarly, carboxylic acid 33 generated a primary alkyl radical which cyclised to yield the new compound oxacyclopentane-3-spiro-2-6,6- dimethylbicyclo[3.1.1]heptane in 10% yield. The tin-mediated cyclisation of 6,6-dimethyl- 2-(2-iodoethoxymethyl)bicyclo[3.1.1]hept-2-ene 37 yielded the same spiro compound in 31% yield. EPR spectroscopic studies provided direct evidence for the formation of the cyclohexadienyl radicals from all of the carboxylic acids investigated. Carboxylic acids 15- 17 and l-[2-(ethenyloxy)benzyl]cyclohexa-2,5-diene-l-carboxylic acid 34 also generated alkyl radicals which were clearly observed by EPR spectroscopy. The carboxylic acid radical precursors would have yielded products in higher yields if the competitive loss of a hydroxyformyl radical did not occur. An account of our work directed towards the synthesis of l-phenylcyclohexa-2,5-diene-l- carboxylic acid 8 is given. Thus, 1,4-dihydrobiphenyl was deprotonated with BuLi, added to CO2 and the isomeric acid, 3-carboxylic acid-3,4-dihydrobiphenyl was removed by reacting with maleic anhydride to give the Diels-Alder adduct. 2-(Cyclohex-2-enyloxy)ethyl l-phenylcyclohexa-2,5-diene-l-carboxylate 24 was treated with dibenzoyl peroxide to afford 7-oxabicyclo[4.3.0]nonane in yields of 32-36%. A variety of N-carboalkoxy-l,2-dihydropyridines have been prepared from the reaction of pyridine and the appropriate chloroforniate in the presence of NaBH4. EPR studies have shown that these esters produce aza-cyclohexadienyl radicals on photolysis in the presence of di-t-butyl peroxide, but no decarboxylation was observed. These compounds do not generate alkyl radicals efficiently when reacted with dibenzoyl peroxide. In each case the major product identified was the corresponding benzoate ester, which resulted from the combination of an alkoxycarbonyl radical and a phenyl radical.

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Книги з теми "Organotin compounds":

Schumann, Herbert, and Ingeborg Schumann. Sn Organotin Compounds. Edited by Ulrich Krüerke. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-662-06612-6.

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Schumann, Herbert, and Ingeborg Schumann. Sn Organotin Compounds. Edited by Ulrich Krüerke. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-09147-0.

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Schumann, Herbert, Ingeborg Schumann, Rainer Bohrer, Bernd Kalbskopf, and Hans-Jürgen Richter-Ditten. Sn Organotin Compounds. Edited by Ulrich Krüerke. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-662-09150-0.

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Schumann, Herbert, and Ingeborg Schumann. Sn Organotin Compounds. Edited by Ulrich Krüerke. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-662-09165-4.

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Schumann, Herbert, and Ingeborg Schumann. Sn Organotin Compounds. Edited by K. C. Buschbeck, H. Bergmann, J. Füssel, H. Hartwig, B. Heibel, H. Katscher, R. Keim, et al. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-662-06750-5.

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Omae, Iwao. Organotin chemistry. Amsterdam: Elsevier, 1989.

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Canada, Canada Environment, Canada. Health and Welfare Canada., and Canada, eds. Non-pesticidal organotin compounds. [Ottawa]: Environment Canada, 1993.

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Davies, Alwyn George. Organotin chemistry. 2nd ed. Weinheim: Wiley-VCH, 2004.

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Davies, Alwyn George. Organotin chemistry. 2nd ed. Weinheim: VCH, 2004.

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Davies, Alwyn George. Organotin chemistry. Weinheim: VCH, 1997.

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Частини книг з теми "Organotin compounds":

Schumann, Herbert, and Ingeborg Schumann. "Organotin Compounds." In Sn Organotin Compounds, 1–234. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-09147-0_1.

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Schumann, Herbert, Ingeborg Schumann, Rainer Bohrer, Bernd Kalbskopf, Hans-Jürgen Richter-Ditten, and Ulrich Krüerke. "Organotin Compounds." In Sn Organotin Compounds, 1–187. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-662-09150-0_1.

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Schumann, Herbert, and Ingeborg Schumann. "Organotin Compounds." In Sn Organotin Compounds, 1–285. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-662-09165-4_1.

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Blunden, Stephen J., and Colin J. Evans. "Organotin Compounds." In The Handbook of Environmental Chemistry, 1–44. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-540-46211-8_1.

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Schumann, Herbert, Ingeborg Schumann, K. C. Buschbeck, H. Bergmann, J. Füssel, H. Hartwig, B. Heibel, et al. "Organotin Compounds." In Sn Organotin Compounds, 1–212. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-662-06750-5_1.

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Fugami, Keigo, and Masanori Kosugi. "Organotin Compounds." In Topics in Current Chemistry, 87–130. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/3-540-45313-x_4.

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Schumann, Herbert, Ingeborg Schumann, and Ulrich Krüerke. "Organotin Compounds." In Sn Organotin Compounds, 1–379. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-662-06612-6_1.

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Champ, Michael A., and Terry L. Wade. "Regulatory Policies and Strategies for Organotin Compounds." In Organotin, 55–94. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-1507-7_3.

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Laughlin, Roy B., John Thain, Brad Davidson, Aldis O. Valkirs, and Frederick C. Newton. "Experimental Studies of Chronic Toxicity of Tributyltin Compounds." In Organotin, 191–217. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-1507-7_10.

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Lee, Maw-Rong, and Chung-Yu Chen. "Organotin Compounds Analysis." In Analysis of Endocrine Disrupting Compounds in Food, 269–87. Oxford, UK: Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781118346747.ch11.

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Тези доповідей конференцій з теми "Organotin compounds":

Kaluđerović, Goran. "MESOPOROUS SILICA AS A VEHICLE FOR ORGANOTIN(IV) COMPOUNDS." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac,, 2021. http://dx.doi.org/10.46793/iccbi21.060k.

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Free Ph3Sn(CH2)nOH (n = 3, 4, 6, 8 and 11) and immobilized organotin(IV) compounds, SBA- 15~Cl|Ph3Sn(CH2)nOH, were prepared and tested against different tumor cell lines. Both compounds and nanomaterials revealed strong cytotoxic potential. SBA-15~Cl|Ph3Sn(CH2)3OH as well as free compound induce caspase triggered apoptosis in human ovarian A2780 cells. Ph3Sn(CH2)6OH and corresponding nanomaterial induced apoptosis in mouse melanoma B16 cells. Survived clones of B16 cells demonstrated phenotypic changes, they differentiate toward melanocytes.

Humphrey, B., and D. Hope. "Analysis of Water, Sediments, and Biota for Organotin Compounds." In OCEANS '87. IEEE, 1987. http://dx.doi.org/10.1109/oceans.1987.1160626.

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Young, D., P. Schatzberg, F. Brinckman, M. Champ, S. Holm, and R. Landy. "Summary Report - Interagency Workshop on Aquatic Sampling and Analysis for Organotin Compounds." In OCEANS '86. IEEE, 1986. http://dx.doi.org/10.1109/oceans.1986.1160347.

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Cherek, Paulina, Michaela Balogova, Krishna Damodaran, and Helga M. Ögmundsdottir. "Abstract 2807: Cytotoxic activity of novel organotin compounds against different cancer cell lines." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-2807.

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Ivanovski, Vladimir, Til Becker, Ivana Predarska, Evamarie Hey-Hawkins, and Goran N. Kaluđerović. "IR and Raman spectroscopy: monitoring immobilization of some anticancer organotin(IV) compounds on mesoporous silica." In Biomedical Spectroscopy, Microscopy, and Imaging III, edited by Jürgen Popp and Csilla Gergely. SPIE, 2024. http://dx.doi.org/10.1117/12.3029524.

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Massari, Federica, Pietro Cotugno, Angelo Tursi, Paola Milella, Stefania Lisco, Giovanni Scardino, Giovanni Scicchitano, et al. "Mapping of Organotin compounds in sediments of Mar Piccolo (Taranto, Italy) using Gas Chromatography-Mass Spectrometry analysis and geochemical data." In 2021 International Workshop on Metrology for the Sea; Learning to Measure Sea Health Parameters (MetroSea). IEEE, 2021. http://dx.doi.org/10.1109/metrosea52177.2021.9611609.

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Ciavell, C., P. Seligman, and P. Stang. "Automated Analysis of Organotins Compounds: A Method for Monitoring Butyltins in the Marine Environment." In OCEANS '86. IEEE, 1986. http://dx.doi.org/10.1109/oceans.1986.1160368.

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Pitta, Marina Galdino da Rocha, Jordy Silva de Carvalho, Luzilene Pereira de Lima, and Ivan da Rocha Pitta. "iPSC therapies applied to rehabilitation in parkinson’s disease." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.022.

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Background: Parkinson’s disease (PD) is a neurological disorder that affects movement, mainly due to damage and degeneration of the nigrostriatal dopaminergic pathway. The diagnosis is made through a clinical neurological analysis where motor characteristics are considered. There is still no cure, and treatment strategies are focused on symptoms control. Cell replacement therapies emerge as an alternative. Objective: This review focused on current techniques of induced pluripotent stem cells (iPSCs). Methods: The search terms used were: “Parkinson’s Disease”, “Stem cells” and “iPSC”. Open articles written in English, from 2016-21 were selected in the Pubmed database, 10 publications were identified. Results: With the modernization of iPSC, it was possible to reprogram pluripotent human somatic cells and generate dopaminergic neurons and individual-specific glial cells. To understand the molecular basis, cell and animal models of neurons and organelles are currently being employed. Organoids are derived from stem cells in a three-dimensional matrix, such as matrigel or hydrogels derived from animals. The neuronal models are: α-synuclein (SNCA), leucine-rich repeat kinase2 (LRRK2), PARK2, putative kinase1 induced by phosphatase and tensin homolog (PINK1), DJ-1. Both models offer opportunities to investigate pathogenic mechanisms of PD and test compounds on human neurons. Conclusions: Cell replacement therapy is promising and has great capacity for the treatment of neurodegenerative diseases. Studies using iPSC neuron and PD organoid modeling is highly valuable in elucidating relevants neuronal pathways and therapeutic targets, moreover providing important models for testing future therapies.