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Статті в журналах з теми "Nucleic acid based drug"
Tan, Xuyu, Fei Jia, Ping Wang, and Ke Zhang. "Nucleic acid-based drug delivery strategies." Journal of Controlled Release 323 (July 2020): 240–52. http://dx.doi.org/10.1016/j.jconrel.2020.03.040.
Повний текст джерелаKim, Haejoo, and Minseok Kwak. "Structures and Applications of Nucleic Acid-Based Micelles for Cancer Therapy." International Journal of Molecular Sciences 24, no. 2 (January 13, 2023): 1592. http://dx.doi.org/10.3390/ijms24021592.
Повний текст джерелаKuriyama, Naoya, Yusuke Yoshioka, Shinsuke Kikuchi, Akihiko Okamura, Nobuyoshi Azuma, and Takahiro Ochiya. "Challenges for the Development of Extracellular Vesicle-Based Nucleic Acid Medicines." Cancers 13, no. 23 (December 6, 2021): 6137. http://dx.doi.org/10.3390/cancers13236137.
Повний текст джерелаWu, Yuanbing, Ania Rashidpour, María Pilar Almajano, and Isidoro Metón. "Chitosan-Based Drug Delivery System: Applications in Fish Biotechnology." Polymers 12, no. 5 (May 21, 2020): 1177. http://dx.doi.org/10.3390/polym12051177.
Повний текст джерелаde Vries, Jan Willem, Feng Zhang, and Andreas Herrmann. "Drug delivery systems based on nucleic acid nanostructures." Journal of Controlled Release 172, no. 2 (December 2013): 467–83. http://dx.doi.org/10.1016/j.jconrel.2013.05.022.
Повний текст джерелаMulvey, Matthew C., Margaret Lemmon, Stephanie Rotter, Jonathan Lees, Leo Einck, and Carol A. Nacy. "Optimization of a Nucleic Acid-Based Reporter System To Detect Mycobacterium tuberculosis Antibiotic Sensitivity." Antimicrobial Agents and Chemotherapy 59, no. 1 (November 3, 2014): 407–13. http://dx.doi.org/10.1128/aac.03135-14.
Повний текст джерелаAshrafuzzaman, Md. "Aptamers as Both Drugs and Drug-Carriers." BioMed Research International 2014 (2014): 1–21. http://dx.doi.org/10.1155/2014/697923.
Повний текст джерелаPozharov, Vitaly P., and Tamara Minko. "Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges." Pharmaceutics 15, no. 1 (January 5, 2023): 194. http://dx.doi.org/10.3390/pharmaceutics15010194.
Повний текст джерелаCampuzano, Susana, María Pedrero, and José M. Pingarrón. "Electrochemical Nucleic Acid-Based Biosensing of Drugs of Abuse and Pharmaceuticals." Current Medicinal Chemistry 25, no. 33 (October 24, 2018): 4102–18. http://dx.doi.org/10.2174/0929867324666171121103156.
Повний текст джерелаDu, Rong, Chen Wang, Ling Zhu, and Yanlian Yang. "Extracellular Vesicles as Delivery Vehicles for Therapeutic Nucleic Acids in Cancer Gene Therapy: Progress and Challenges." Pharmaceutics 14, no. 10 (October 19, 2022): 2236. http://dx.doi.org/10.3390/pharmaceutics14102236.
Повний текст джерелаДисертації з теми "Nucleic acid based drug"
Wong, Frances M. P. "Lipid-based vehicles for nucleic acid drugs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0015/NQ56644.pdf.
Повний текст джерелаSatyal, Uttam. "Efficient Drug and Nucleic Acid Delivery Systems based on Synthetic Amphiphiles with Tuned Oil/Water Interfaces." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/531985.
Повний текст джерелаPh.D.
Today, drugs are an integral part of healthy human life, with new drug entities being introduced every year in clinic. The advancement of drug development brings complexity and variation, in terms of both physical and chemical properties. Some of these physicochemical characteristics are many times suboptimal, eventually requiring robust delivery systems that can precisely deliver the drugs to the desired tissues. Although many materials have been studied for the generation of drug delivery systems, there is always a need for biomaterials with better properties that can translate into superior delivery systems. In this context, new drug delivery systems that are interface-engineered at materials level for better stability and delivery efficiency in vitro and in vivo are introduced in this dissertation. In the first part of the dissertation, novel oil/water interface-engineered amphiphilic block copolymer micelles that were previously introduced by our lab were assessed for their stability in the presence of various esterase enzymes present in serum and on blood vessel walls, normally encountered by drug delivery systems on route to the targeted tissues. I also assessed the vulnerability of the polymeric micelles in presence of enzymes typically present either inside the tumor cells or secreted in the tumor microenvironment. I revealed the selective stability of empty- and docetaxel-loaded polymeric micelles to enzymatic degradation en route/in tumors and I have correlated this selective stability with polymer structure and interfacial engineering mentioned above. The unique delivery capabilities of interfacial-engineered polymeric micelles were tested in vivo using a mouse model of triple negative breast cancer. We proved that our novel engineered triblock copolymer-based drug delivery systems are superior to similar delivery systems made out of standard diblock copolymer micelles and also to the clinically used Taxotere® formulation towards cancer cell killing and tumor treatment, without displaying any significant toxicity in experimental animals. The second part of the dissertation focuses on the development and assessment of a pyridinium-based pseudo-gemini surfactant that combined the high nucleic acid packaging capacity of pyridinium lipids with the high transfection efficiency of gemini surfactants while displaying a reduced associated cytotoxic effect. I have analyzed the temperature treatment on compaction of nucleic acids into lipoplexes and I have established a high temperature annealing method for this purpose. This novel formulation technique allowed a substantial reduction of the amount of amphiphiles required to compact a specific amount of nucleic acids. This in turn also reduced the cytotoxic effect associated with the use of pyridinium amphiphiles. The effect of inclusion of colipids to lipoplex compaction, the robustness and the transfection efficiency of the lipid/nucleic acid lipoplex systems were assessed in detail, and correlations between formulation composition and biological activity were established. I was also able to show for the first time that pyridinium pseudo-gemini surfactants were able to compact different types of nucleic acids, including pDNA, mRNA and siRNA at lower charge ratios than standard, state-of-the art formulations used for this purposes. I also showed that irrespective to the nucleic acid compacted within the lipoplexes, the novel amphiphiles can efficiently deliver the cargo into the targeted cells even in the presence of very high concentration of serum, a premise for future use of these amphiphiles and formulations in vivo.
Temple University--Theses
Pel, Joel. "A novel electrophoretic mechanism and separation parameter for selective nucleic acid concentration based on synchronous coefficient of drag alteration (SCODA)." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/13402.
Повний текст джерелаFolly, da Silva Constantino Laura. "An effective layered workflow of virtual screening for identification of active ligands of challenging protein targets." Thesis, University of Iowa, 2017. https://ir.uiowa.edu/etd/5754.
Повний текст джерелаBELGIOVINE, GIULIANA. "Delivery of small interfering RNA into airway epithelial cells. Downregulation of the pro-inflammatory cytokine high mobility group BOX 1." Doctoral thesis, Università di Foggia, 2016. http://hdl.handle.net/11369/338921.
Повний текст джерелаAkhras, Michael S. "Nucleic Acid Based Pathogen Diagnostics." Doctoral thesis, KTH, Skolan för bioteknologi (BIO), 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4684.
Повний текст джерелаPatogena organismer smittas till värd organismen genom alla möjliga kontaktnätverk och skapar en mångfald olika sjukdomstillstånd. Dock är det fortfarande vanligt förekommande behandlingsbara infektiösa sjukdomar som orsakar den största hälsoförlusten, sett från ett globalt perspektiv. Bill och Melinda Gates Stiftelsen samarbetade med RAND kooperation för att forma “The Global Health Diagnostics Forum”. Deras mål var att etablera och analysera matematiska modeller för vilka effekter en ny diagnostisk metod utrustat för fältarbete skulle ha i utvecklingsländer. Resultaten var häpnadsveckande, med potentiellt miljoner av liv som skulle kunna räddas på en årlig basis. Den etablerade standarden för diagnostik av patogena bakterier har länge varit kultiveringsmedia baserad. Miljö specialiserade biologer har estimerat att mindre än 1 % av alla bakterie arter går att kultivera. Dock erbjuder genetiska analyser potentialen att kunna identifiera alla mikrober från alla de biologiska rikena. Nukleinsyrebaserade diagnostiska metoder har märkbart förbättrats över de senaste årtionden. Nya tekniker erbjuder utökad sensitivitet, selektivitet, sänkta kostnader och parallella analyser av patient prover. Dock är de flesta metoderna begränsade till standardiserade laboratoriemiljöer. För att konstruera en väl fungerande diagnostisk fältutrustning för användning i problem områden, behöver världsledande tekniker identifieras och kombineras. Fokuseringsområdet för denna doktorsavhandling har varit att utveckla och utföra nukleinsyrebaserade metoder för patogen diagnostik. Metoder och experimentella utförande applicerades på två distinkta system i) sökning av antibiotika resistens relaterade mutationer i den patogena bakterien Neisseria gonorrhoeae och ii) genotypning av det cancer orsakande Humana Papillomaviruset (HPV). Den första delen av studien inriktade sig mot utveckling av snabba, direkta och multiplexa Pyrosekvenserings baserade nukleinsyreanalyser. Med förbättrad provprepareringsmetodologi kunde vi detektera multipla HPV infektioner med högre sensitivitet än vad tidigare beskrivits med liknande metodologi. Den andra delen av studien fokuserades på multiplexa nukleinsyre amplifikationer med “Molecular Inversion Probe” tekniken med sista steg Pyrosekvenserings analys. “PathogenMip assay” erbjuder ett komplett detektionsprotokoll för alla kända patogena organismer. Vi introducerar även den nya “Connector Inversion Probe”, en “Padlock Probe” kapabel att genomföra kompletta gap fyllningar för multiplex nukleinsyre amplifiering.
QC 20100624
Elmén, Joacim. "Nucleic acid based therapeutic approaches /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-047-8/.
Повний текст джерелаAllsop, Julie Kay. "Development of nucleic acid vaccines for mucosal delivery." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263104.
Повний текст джерелаZhou, Chenguang. "NANOCARRIERS FOR THERAPEUTIC NUCLEIC ACID DELIVERY." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1336584204.
Повний текст джерелаO'Daniel, Peter Ivo. "Exploring structural diversity in nucleoside and nucleic acid drug design." Diss., Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-08252005-130946/.
Повний текст джерелаBarefield, E. Kent, Committee Member ; Beckham, Haskell W., Committee Member ; Doyle, Donald F., Committee Member ; Weck, Marcus, Committee Member ; Seley, Katherine L., Committee Chair.
Книги з теми "Nucleic acid based drug"
1946-, Propst C. L., and Perun Thomas J, eds. Nucleic acid targeted drug design. New York: M. Dekker, 1992.
Знайти повний текст джерелаMethods for studying nucleic acid/drug interactions. Boca Raton: Taylor & Francis, 2012.
Знайти повний текст джерелаKim, Sung Wan. Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics. Edited by Ram I. Mahato. Abingdon, UK: Taylor & Francis, 2002. http://dx.doi.org/10.4324/9780203300961.
Повний текст джерелаI, Mahato Ram, and Kim Sung Wan, eds. Pharmaceutical perspectives of nucleic acid-based therapeutics. London: Taylor & Francis, 2002.
Знайти повний текст джерелаPullman, Bernard, and Joshua Jortner, eds. Molecular Basis of Specificity in Nucleic Acid-Drug Interactions. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-011-3728-7.
Повний текст джерелаLuo, Yunbo. Functional Nucleic Acid Based Biosensors for Food Safety Detection. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8219-1.
Повний текст джерелаKrul, Kenneth G. The nucleic acid-based therapeutics: World markets, developments and applications. Edited by Heffner Steven and Kalorama Information LLC. New York, N.Y: Kalorama Information, 2005.
Знайти повний текст джерелаCorporation, InteLab, ed. U.S. markets for nucleic acid probe-based diagnostic products, 1994-2001. Mission Viejo, CA: InteLab Corporation, 1996.
Знайти повний текст джерелаLi, Tang. Development of liposome-based nucleic acid analyses for rapid detection of listeria monocytogenes. Ithaca, NY: Cornell University, 2003.
Знайти повний текст джерелаDaly, Nathan Scott. Single-molecule studies of nucleic acid dynamics using carbon nanotube-based field-effect transistors. [New York, N.Y.?]: [publisher not identified], 2017.
Знайти повний текст джерелаЧастини книг з теми "Nucleic acid based drug"
Zhang, A. Yin, and Susanna Wu-Pong. "Small Nucleic Acid-Based Drugs: Successes and Pitfalls." In Biopharmaceutical Drug Design and Development, 193–221. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-532-9_10.
Повний текст джерелаKardani, Sunil, and Devendra Vaishnav. "Potential Applications of Cationic Lipids in Nucleic Acid-Based Therapeutic Delivery System." In Nanocarriers: Drug Delivery System, 329–47. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-4497-6_13.
Повний текст джерелаMahmood, Mohammed Arif I., Umair J. M. Khan, and Samir M. Iqbal. "Nucleic Acid-Based Encapsulations for Cancer Diagnostics and Drug Delivery." In DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases, 163–87. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-662-45775-7_7.
Повний текст джерелаKim, Kyoung-Ran, Junghyun Kim, and Dae-Ro Ahn. "Tissue-Specific Drug Delivery Platforms Based on DNA Nanoparticles." In Handbook of Chemical Biology of Nucleic Acids, 1–28. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-1313-5_54-1.
Повний текст джерелаFaneca, Henrique, Ana Luísa Cardoso, Sara Trabulo, Sónia Duarte, and Maria C. Pedroso de Lima. "Cationic Liposome-Based Systems for Nucleic Acid Delivery: From the Formulation Development to Therapeutic Applications." In Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment, 153–84. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6010-3_6.
Повний текст джерелаHigashi, Taishi, Keiichi Motoyama, and Hidetoshi Arima. "Cyclodextrin-Based Drug Carriers for Low Molecular Weight Drugs, Proteins, and Nucleic Acids." In Methods in Pharmacology and Toxicology, 27–45. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3121-7_2.
Повний текст джерелаPêgo, Ana Paula, Hugo Oliveira, and Pedro Miguel Moreno. "Biomaterial-Based Vectors for Targeted Delivery of Nucleic Acids to the Nervous System." In Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment, 185–224. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6010-3_7.
Повний текст джерелаZhang, Xiaolin, and Yunfeng Lin. "The Application and Problems of Tetrahedral Framework Nucleic Acids as a Drug Carrier in Biomedicine Fields." In Advances in Nanomaterials-based Cell Biology Research, 137–66. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2666-1_5.
Повний текст джерелаLohmann, Sabine, Beatrix Bahle, Andrea Herold, and Julian Schuster. "Formalin-Fixed Paraffin-Embedded Tissue (FFPET) Sections for Nucleic Acid-Based Analysis in Biomarker Discovery and Early Drug Development." In Biomarkers in Disease: Methods, Discoveries and Applications, 187–219. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-007-7696-8_24.
Повний текст джерелаLohmann, Sabine, Beatrix Bahle, Andrea Herold, and Julian Schuster. "Formalin-Fixed Paraffin-Embedded Tissue (FFPET) Sections for Nucleic Acid-Based Analysis in Biomarker Discovery and Early Drug Development." In General Methods in Biomarker Research and their Applications, 1–26. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-007-7740-8_24-1.
Повний текст джерелаТези доповідей конференцій з теми "Nucleic acid based drug"
Arshavsky-Graham, Sofia, Rita Vilneski, Federico Faratore, Moran Bercovici, and Ester Segal. "1,000-fold Sensitivity Enhancement of Porous Si-based Optical Biosensors for Nucleic Acid and Proteins Detection." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2017. http://dx.doi.org/10.1364/omp.2017.omm4d.6.
Повний текст джерелаVasilyeva, Svetlana, Nikolai Li-Zhulanov, Asya Levina, Valentina Zarytova, and Vladimir Silnikov. "Drug delivery systems based on SiO2-nanoparticles bearing covalently bound triphosphates of nucleoside analogs." In XVIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2014. http://dx.doi.org/10.1135/css201414394.
Повний текст джерелаKrasnoshtanova, Alla, and Elisaveta Borovkova. "OBTAINING NUCLEIC ACID PREPARATIONS AND THEIR HYDROLYSATES FROM BIOMASS OF METHANE-OXIDIZING BACTERIA." In GEOLINKS Conference Proceedings. Saima Consult Ltd, 2021. http://dx.doi.org/10.32008/geolinks2021/b1/v3/14.
Повний текст джерелаMeena, G. G., M. A. Stott, D. Ozcelik, T. A. Wall, R. Robison, A. R. Hawkins, and H. Schmidt. "MMI waveguide based multispectral detection of nucleic acids for analysis of drug-resistant bacteria." In 2016 IEEE Photonics Conference (IPC). IEEE, 2016. http://dx.doi.org/10.1109/ipcon.2016.7831137.
Повний текст джерелаSchramm, Vern L., Richard H. Furneaux, Peter C. Tyler, and Gary B. Evans. "Enzymatic transition states and drug design." In XVIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2014. http://dx.doi.org/10.1135/css201414032.
Повний текст джерелаAtkin, Stephen L., Sylvain Barrier, Stephen T. Beckett, Tom Brown, Grahame Mackenzie, and Leigh Madden. "Towards the use of sporopollenin in drug delivery: Efficient encapsulation of oligonucleotides." In XIIIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200507307.
Повний текст джерелаKiuru, Emilia, Mikko Ora, Leonid Beigelman, Lawrence Blatt, and Harri Lönnberg. "On the feasibility of an esterase-dependent pro-drug strategy for 2-5A." In XVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112184.
Повний текст джерелаSwarbrick, Joanna M., and Barry V. L. Potter. "Cyclic adenosine 5'-diphosphate ribose signalling: towards drug-like analogues to modulate CD38 and calcium release." In XVIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2014. http://dx.doi.org/10.1135/css201414111.
Повний текст джерелаSatish, D. "Ionization Potentials of Nucleic Acid Intercalators." In Functional Materials and Applied Physics. Materials Research Forum LLC, 2022. http://dx.doi.org/10.21741/9781644901878-12.
Повний текст джерелаLabuda, Jan. "Concepts and terms at electrochemical nucleic acid-based biosensors." In 2009 2nd International Symposium on Applied Sciences in Biomedical and Communication Technologies (ISABEL). IEEE, 2009. http://dx.doi.org/10.1109/isabel.2009.5373647.
Повний текст джерелаЗвіти організацій з теми "Nucleic acid based drug"
Lebron, Carmen, Erik Petrovskis, Frank Loffler, and Keith Henn. Use of Nucleic Acid-Based Tools for Monitoring Biostimulation and Bioaugmentation. Fort Belvoir, VA: Defense Technical Information Center, January 2011. http://dx.doi.org/10.21236/ada546746.
Повний текст джерелаVangelas, K., E. ELIZABETH EDWARDS, F. FRANK LOFFLER, and B. Brian02 Looney. ADVANCEMENT OF NUCLEIC ACID-BASED TOOLS FOR MONITORING IN SITU REDUCTIVE DECHLORINATION. US: SRS, November 2006. http://dx.doi.org/10.2172/898370.
Повний текст джерелаKingsley, Mark T. Nucleic Acid-Based Detection and Identification of Bacterial and Fungal Plant Pathogens - Final Report. Office of Scientific and Technical Information (OSTI), March 2001. http://dx.doi.org/10.2172/781863.
Повний текст джерелаKingsley, Mark T. Nucleic Acid-Based Detection and Identification of Bacterial and Fungal Plant Pathogens - Final Report. Office of Scientific and Technical Information (OSTI), March 2001. http://dx.doi.org/10.2172/965696.
Повний текст джерелаCuevas, Christian, Jennifer De Lurio, Andrew Furman, Randy Hulshizer, Marcus Lynch, and Prital Patel. PCORI COVID-19 Scan: BinaxNOW COVID-19 Ag Card, Saliva-based Nucleic Acid Assays (September 3-16, 2020). Patient-Centered Outcomes Research Institute (PCORI), September 2020. http://dx.doi.org/10.25302/bcs9.2020.9.
Повний текст джерелаSemaan, Dima, and Linda Scobie. Feasibility study for in vitro analysis of infectious foodborne HEV. Food Standards Agency, September 2022. http://dx.doi.org/10.46756/sci.fsa.wfa626.
Повний текст джерелаPorat, Ron, Gregory T. McCollum, Amnon Lers, and Charles L. Guy. Identification and characterization of genes involved in the acquisition of chilling tolerance in citrus fruit. United States Department of Agriculture, December 2007. http://dx.doi.org/10.32747/2007.7587727.bard.
Повний текст джерела