Готові списки джерел за темами / Nobot

Добірка наукової літератури з теми "Nobot"

Автор: Grafiati
Опубліковано: 30 травня 2022
Оновлено: 31 травня 2022

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Статті в журналах з теми "Nobot"

1

Menten, Lawrence E., Aiyou Chen, and Dimitrios Stiliadis. "NoBot: Embedded malware detection for endpoint devices." Bell Labs Technical Journal 16, no. 1 (May 16, 2011): 155–70. http://dx.doi.org/10.1002/bltj.20492.

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2

Kochman, J. "Plasmopara helianthi Novot. na słoneczniku w Polsce[Plasmopara helianthi Nowot. on sunflower plants in Poland]." Acta Agrobotanica 30, no. 2 (2015): 239–45. http://dx.doi.org/10.5586/aa.1977.018.

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3

Tripurani, S. K., K. B. Lee, L. Wang, G. W. Smith, and J. Yao. "5 CLONING AND CHARACTERIZATION OF NEWBORN OVARY HOMEOBOX GENE (NOBOX) IN CATTLE." Reproduction, Fertility and Development 22, no. 1 (2010): 160. http://dx.doi.org/10.1071/rdv22n1ab5.

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Анотація:
Newborn ovary homeobox (NOBOX) is a homeobox gene that is preferentially expressed in the oocytes and is essential for folliculogenesis in mice. NOBOX knockout mice are infertile, and lack of NOBOX perturbs the expression of many germ-cell-specific genes and microRNAs. Furthermore, mutations in the NOBOX gene associated with premature ovarian failure have been described in humans. However, the temporal and cell-specific expression of NOBOX in bovine oocytes and the potential function of NOBOX in early embryogenesis have not been described previously. The objectives of this study were to clone the complementary (c)DNA encoding for bovine NOBOX, analyze the expression of NOBOX mRNA in bovine tissues including fetal ovaries of different developmental stages, and characterize the temporal expression patterns of NOBOX mRNA during oocyte maturation and early embryogenesis. Based on the sequence of a predicted cDNA for bovine NOBOX, we successfully amplified, using RT-PCR, a cDNA fragment representing the coding region of bovine NOBOX from bovine fetal ovary cDNA. Additional 5′ and 3′ sequences were obtained using rapid amplification of cDNA ends (RACE) procedures. The assembled full-length NOBOX cDNA is 2275 bp with an open reading frame encoding a protein of 500 amino acids with a conserved homeodomain and typical nuclear localization signal. The predicted NOBOX protein shares 61% and 49% amino acid sequence identity with its human and mouse counterparts, respectively. A BLAST search of the bovine genome database at the National Center for Biotechnology Information (NCBI) revealed that the bovine NOBOX gene is located on chromosome 4, spans approximately 5.5 kb, and is encoded by 7 exons. Northern blot analysis revealed an approximately 2.3-kb bovine NOBOX RNA transcript. RT-PCR analysis of RNA samples from a panel of 14 different bovine tissues revealed that expression of NOBOX mRNA is restricted to ovarian samples and can be detected in fetal ovaries harvested as early as 105 days of gestation, when primary follicles start to form. Further RT-PCR analysis using RNA isolated from oocytes and granulosa and cumulus cells of antral follicles indicates that bovine NOBOX is expressed in oocytes but not in other follicular cells. Real-time PCR analysis demonstrated that NOBOX mRNA is abundant in germinal vesicle and metaphase II stage oocytes, as well as from pronuclear to 8-cell stage embryos, but barely detectable in embryos collected at the morula and blastocyst stages, suggesting that NOBOX might be a maternal effect gene. Collectively, our results demonstrate that bovine NOBOX is specifically expressed in oocytes and may play a role in early embryonic development in addition to its known function in folliculogenesis.
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Bouilly, Justine, Florence Roucher-Boulez, Anne Gompel, Hélène Bry-Gauillard, Kemal Azibi, Cherif Beldjord, Catherine Dodé, et al. "New NOBOX Mutations Identified in a Large Cohort of Women With Primary Ovarian Insufficiency Decrease KIT-L Expression." Journal of Clinical Endocrinology & Metabolism 100, no. 3 (March 1, 2015): 994–1001. http://dx.doi.org/10.1210/jc.2014-2761.

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Context: Primary ovarian insufficiency (POI) is a major cause of anovulation and infertility in women. This disease affects 1% of women before 40 years, and several genetic causes have been reported. Objective: The aim of the study was to evaluate the prevalence of NOBOX mutations in a new large cohort of women with POI and to characterize these variants and identify a NOBOX novel target gene. Patients and Methods: A total of 213 unrelated patients with POI were screened for NOBOX mutations, and luciferase reporter assays were performed for the mutations identified. Results: We reported 3 novel and 2 recurrent heterozygous missense NOBOX rare variants found in 12 patients but not in 724 alleles from ethnic-matched individual women with occurrence of menopause at a normal age. Their functional impact had been tested on the classic growth differentiation factor-9 (GDF9) promoter and on KIT-L, a new NOBOX target gene. The p.Gly91Thr, p.Gly111Arg, p.Arg117Trp, p.Lys371Thr, and p.Pro619Leu mutations were deleterious for protein function. Conclusions: In our series, 5.6% of the patients with POI displayed heterozygous NOBOX mutations. We demonstrate that KIT-L could be now a direct NOBOX target. These findings replicate the high prevalence of the association between the NOBOX rare variants and POI.
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5

Zambrano Alvarado, Jessica Thalia. "Roberto Noboa." Index, revista de arte contemporáneo, no. 09 (July 1, 2020): 218–23. http://dx.doi.org/10.26807/cav.v0i09.354.

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La pintura de Roberto Noboa ha sido descrita como “figuración especulativa”, y la densidad semántica de sus composiciones como propiciadoras de “la conjetura y el híper subjetivismo interpretativo”, o como “una narración incómoda y cómplice”. Su trabajo, gestado desde los años 90 en Guayaquil, no se puede asociar a las prácticas dominantes en el arte ecuatoriano del período y, a pesar de su fecundidad, continúa desarrollándose de manera distante a la escena contemporánea, más allá de su creciente influencia en el medio. El libro de la editorial EACHEVE recoge más de 200 cuadros del artista, analizando su proceso creativo y proponiendo perspectivas de análisis sobre su obra a partir de entrevistas, ensayos y registros visuales, que incluyen no solo sus pinturas sino también sus libretas de trabajo.
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Yao, Changfang, Likui Lu, Yiting Ji, Yingying Zhang, Weisheng Li, Yajun Shi, Jinliu Liu, Miao Sun, and Fei Xia. "Hypo-Hydroxymethylation of Nobox is Associated with Ovarian Dysfunction in Rat Offspring Exposed to Prenatal Hypoxia." Reproductive Sciences 29, no. 5 (March 7, 2022): 1424–36. http://dx.doi.org/10.1007/s43032-022-00866-6.

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AbstractPrenatal hypoxia (PH) is a common feature of a suboptimal intrauterine environment affecting the development of fetuses. Whether PH leads to abnormal ovary development is not yet clear. This study investigated ovarian function in offspring exposed to PH and the potential underlying molecular mechanisms. SD female rats (n = 12 per group) at 9 weeks of age were housed in individual cages (21% O2). After the pregnant rats were exposed to hypoxia (10.5% oxygen) from embryonic day (E) 5 to E21, PH offspring were generated. All animals maintained normoxia during lactation. The number of follicles was counted in female offspring at 3 months under an optical microscope. The expression of Nobox, Gdf9, and Tets was detected by quantitative real-time polymerase chain reaction (PCR) and Western blot. Global DNA hydroxymethylation was measured by dot blot. The hydroxymethylation level of the Nobox gene was evaluated with an NGS-based multiple targeted CpG hydroxymethylation analysis method. Body weight and ovary weight were significantly decreased in the PH group compared with the control group. PH offspring have abnormal estrous cycle, decreased serum anti-Mullerian hormone (AMH), and increased serum follicle-stimulating hormone (FSH), and follicular atresia, which are consistent with the clinical manifestations in patients with ovarian dysfunction. In terms of mechanism, the expression of Nobox was significantly decreased in the PH group. Subsequent high-throughput sequencing results showed that the level of hydroxymethylation in the candidate region of the Nobox gene was reduced. Cultured cells treated with hypoxia exhibited lower levels of both 5hmC and Nobox, while vitamin C, a coactivator of Tets, rescued hypo-hydroxymethylation and increased the expression level of Nobox. This study indicated that PH could cause hypo-hydroxymethylation of Nobox through epigenetic regulation and may consequently contribute to ovarian dysfunction in adult rat offspring.
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Koiwai, Kotaro, Kazue Inaba, Kana Morohashi, Sora Enya, Reina Arai, Hirotatsu Kojima, Takayoshi Okabe, et al. "An integrated approach to unravel a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo." Journal of Biological Chemistry 295, no. 20 (April 2, 2020): 7154–67. http://dx.doi.org/10.1074/jbc.ra119.011463.

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Ecdysteroids are the principal steroid hormones essential for insect development and physiology. In the last 18 years, several enzymes responsible for ecdysteroid biosynthesis encoded by Halloween genes were identified and genetically and biochemically characterized. However, the tertiary structures of these proteins have not yet been characterized. Here, we report the results of an integrated series of in silico, in vitro, and in vivo analyses of the Halloween GST protein Noppera-bo (Nobo). We determined crystal structures of Drosophila melanogaster Nobo (DmNobo) complexed with GSH and 17β-estradiol, a DmNobo inhibitor. 17β-Estradiol almost fully occupied the putative ligand-binding pocket and a prominent hydrogen bond formed between 17β-estradiol and Asp-113 of DmNobo. We found that Asp-113 is essential for 17β-estradiol–mediated inhibition of DmNobo enzymatic activity, as 17β-estradiol did not inhibit and physically interacted less with the D113A DmNobo variant. Asp-113 is highly conserved among Nobo proteins, but not among other GSTs, implying that this residue is important for endogenous Nobo function. Indeed, a homozygous nobo allele with the D113A substitution exhibited embryonic lethality and an undifferentiated cuticle structure, a phenocopy of complete loss-of-function nobo homozygotes. These results suggest that the nobo family of GST proteins has acquired a unique amino acid residue that appears to be essential for binding an endogenous sterol substrate to regulate ecdysteroid biosynthesis. To the best of our knowledge, ours is the first study describing the structural characteristics of insect steroidogenic Halloween proteins. Our findings provide insights relevant for applied entomology to develop insecticides that specifically inhibit ecdysteroid biosynthesis.
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Melissa H., Novalin. "KEBERADAAN ALAT MUSIK NAFIRI PADA ANSAMBEL NOBAT DIRAJA DI SANGGAR SINAR BUDAYA GROUP MEDAN." Grenek Music Journal 2, no. 2 (April 5, 2013): 1. http://dx.doi.org/10.24114/grenek.v2i2.3826.

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Анотація:
Setelah penelitian ini dilakukan maka dapat disimpulkan bahwa Alat Musik Nafiri yang ada di Sanggar Sinar Budaya Group saat ini hanya tinggal satu buah saja dan kondisinya masih tergolong baik. Nafiri diyakini masih mengandung unsur magis. Selain itu, alat musik ini hanya dikhususkan untuk Ansambel Nobat Diraja, di mana sampai saat ini, di Sumatera Utara hanya Kesultanan Serdang yang masih memiliki ansambel tersebut. Para pemainnya merupakan bagian dari Sanggar Sinar Budaya Group yang dinaungi oleh kesultanan ini. Namun, karena Ansambel Nobat Diraja hanya dimainkan untuk Sultan, mengakibatkan tidak banyak masyarakat umum yang mengetahui tentang Alat Musik Nafiri, padahal memiliki keunikan yang patut diketahui. Maka dapat ditarik kesimpulan bahwa merupakan kebanggaan bagi Kesultanan Serdang karena masih dapat melestarikan Ansambel Nobat Diraja serta memiliki Nafiri dengan kondisi yang masih baik. Namun pengenalan pada masyarakat luas tentang Alat Musik Nafiri sangatlah penting, tentu dengan tidak mengurangi nilai sakral dan magis yang terkandung di dalamnya.
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Gankhurel, Ganzaya, Nomintsetseg Byambajav, Bayaraa Batnasan, and Dolmaa Gania. "The general characteristics and organic matters of therapeutic mud from Lake Noot (Mongolia)." Mongolian Journal of Chemistry 22, no. 48 (July 26, 2021): xx. http://dx.doi.org/10.5564/mjc.v22i48.1644.

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Анотація:
In this investigation, we examined the chemical composition, physicochemical properties, and organic matter of therapeutic mud from Lake Noot in the Arkhangai province of Mongolia. The therapeutic mud from “Lake Noot” is used in the pelotherapy of local health care services for some time but without deep characterization. Due to this, a study of therapeutic mud samples was required. Our research concentrated on identifying general characteristics, organic matter, mineralogical, and chemical composition of therapeutic mud at two different Lake Noot sites. Results showed that the therapeutic mud belongs to the continental hydrogen sulfide sticky mud type. The total organic matter in the therapeutic mud of Lake Noot was 14.44%. Total organic matter contains a humic substance of 42.17%, lipid 16.62%, and carbohydrate 7.13%. A total of 172 compounds were identified in the dissoluble organic matter of therapeutic mud, mainly of natural origin, using the gas chromatography-mass spectrometry (GC/MS) method. The dominant compounds were saturated and unsaturated hydrocarbons with 13–44 carbon atoms and carboxylic acids and their ethers. Some of the identified organic compounds have been reported antimicrobial, anti-inflammatory, antibacterial, and antifungal properties.
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Wang, Zhengpin, Chen-Yu Liu, Yangu Zhao, and Jurrien Dean. "FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse oocyte growth and differentiation." Nucleic Acids Research 48, no. 7 (February 22, 2020): 3525–41. http://dx.doi.org/10.1093/nar/gkaa101.

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Abstract Germ-cell transcription factors control gene networks that regulate oocyte differentiation and primordial follicle formation during early, postnatal mouse oogenesis. Taking advantage of gene-edited mice lacking transcription factors expressed in female germ cells, we analyzed global gene expression profiles in perinatal ovaries from wildtype, FiglaNull, Lhx8Null and Sohlh1Null mice. Figla deficiency dysregulates expression of meiosis-related genes (e.g. Sycp3, Rad51, Ybx2) and a variety of genes (e.g. Nobox, Lhx8, Taf4b, Sohlh1, Sohlh2, Gdf9) associated with oocyte growth and differentiation. The absence of FIGLA significantly impedes meiotic progression, causes DNA damage and results in oocyte apoptosis. Moreover, we find that FIGLA and other transcriptional regulator proteins (e.g. NOBOX, LHX8, SOHLH1, SOHLH2) are co-expressed in the same subset of germ cells in perinatal ovaries and Figla ablation dramatically disrupts KIT, NOBOX, LHX8, SOHLH1 and SOHLH2 abundance. In addition, not only do FIGLA, LHX8 and SOHLH1 cross-regulate each other, they also cooperate by direct interaction with each during early oocyte development and share downstream gene targets. Thus, our findings substantiate a major role for FIGLA, LHX8 and SOHLH1 as multifunctional regulators of networks necessary for oocyte maintenance and differentiation during early folliculogenesis.
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Більше джерел

Дисертації з теми "Nobot"

1

Соколовський, Богдан Максимович. "Мова та компілятор для генерування тексту чат-ботів мовою JavaScript". Bachelor's thesis, КПІ ім. Ігоря Сікорського, 2021. https://ela.kpi.ua/handle/123456789/43371.

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Анотація:
Кваліфікаційна робота включає пояснювальну записку (с. 72, рис. 58, табл. 2, додатки). Об’єкт розробки – створення мови та компілятора для генерування тексту чат-ботів мовою JavaScript, яка буде зручна як для людей, які не пов’язані з інформаційними технологіями, так і навпаки. Головна мета мови – спростити та прискорити створення чат-ботів без додаткових знань мов програмування чи архітектурних рішень, які використовуються під час проєктування програмного забезпечення. Мова для генерування чат-ботів має наступні можливості: • генерування чат-ботів для вебсайтів; • генерування чат-ботів для соціальної мережі «Telegram». Компілятор мови має наступні можливості: • швидко компілювати та аналізувати код, написаний мовою, яка представлена в цьому дипломному проєкті. Генерований код має наступні властивості: • легкий у розумінні; • зручний у модифікації. У процесі розробки були використанні наступні мови програмування: • Common Lisp з використанням наступних бібліотек: «alexandria» та «anaphora» – яка додає додаткову функціональність до мови для зручної розробки, «lisp-unit» – для створення unit-тестів, «cl-ppcre» – для роботи з регулярними виразами, «unix-opts» – для обробки опцій компілятора, які надходять з операційної системи, «yason» – для роботи з JSON-об’єктами, «osicat» – для роботи із символічними посиланнями у unix-подібних операційних системах; • JavaScript з використанням наступних бібліотек: «expressjs» – для створення вебсерверу з використанням HTTP/HTTPS протоколів, «telegrafjs» – для роботи з API соціальної мережі «Telegram», «lodash» – яка додає додаткову функціональність до мови для зручної розробки; Середовища розробки: • WebStorm; • Emacs з додатком Slime. Додаткові програми: • Sbcl для компіляції файлів на мові Common Lisp; • NodeJS для інтерпретації файлів на мові JavaScript; • Було також використано додаток NPM для автоматичної збірки проєкту на мові JavaScript, Apple Safari – веб-браузер для налагодження чат-ботів, які були генеровані для вебсайтів та соціальна мережа «Telegram» для налагодження роботи чат-ботів, які були генеровані для цієї платформи. В ході виконання дипломного проєкту: • розроблено архітектуру системи; • проведений аналіз існуючих рішень; • розроблена мова та компілятор для генерації чат-ботів мовою JavaScript для вебсайту або соціальної мережі. Використання цієї мови та компілятора дозволять прискорити час розробки чат-ботів для різних платформ та надати можливість зосередитися на реалізації основної задачі чат-бота.
Qualification work includes explanatory note (p. 72, fig. 58, tables 2, applications). The object of development is the creation language and compiler for chat-bot generation in JavaScript language, which will be comfortable for people who not affiliated with information technology and vice versa. The main goal of the language to simplify and to accelerate chatbots creation without additional knowledges of programming languages or architecture solutions which using during software development. Language for chatbot generation have the next features: • the ability of chatbot generation for websites. • the ability of chatbot generation of social network “Telegram”; Compiler of language have the next features: • the ability of quick code analyzing and compilation in the language whose introduced in this graduation work; Generated code has the next features: • easy to understanding; • comfortable to modification. The development process used the next programming languages: • Common Lisp with using the next libraries: “alexandria” and “anaphora” which provides additional functionality for language, “lisp-unit” for writing unit-tests, “cl-ppcre” for working with regular expressions, “unix-opts” for handling options of the compiler that passed from operating system, “yason” for working with JSON-objects, “osicat” for working with symbolic links in unix-like operating systems; • JavaScript with using the next libraries: “expressjs” for creation webserver using HTTP/HTTPS protocols, “telegrafjs” for working with API of social network “Telegram”, “lodash” which provides additional functionality for language. Development environments: • WebStorm; • Emacs with Slime extension. Additional programs: • SBCL for compiling files in Common Lisp; • NodeJS for compiling files in JavaScript language; • NPM for auto building projects in JavaScript language; • Apple Safari web-browser for debugging chatbots that generated for websites; • social network “Telegram” for debugging chatbots that generated for this platform. During the implementation of the graduation work: • developed architecture of project; • analysis existent solutions; • developed language and compiler for chat-bots generation in JavaScript language for websites and social networks. Using this language and compiler can accelerate development time of different platforms, and provide focus on the main functionality of chatbot.
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2

Revah, David. "Résonances mystiques dans l'oeuvre "Nosot" du romancier israélien Hayyim Be'er." Paris 8, 2001. http://www.theses.fr/2001PA082016.

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Анотація:
Ce travail porte sur l'étude et l'analyse de Nosot, oeuvre de Hayyim Bé'er, romancier israélien, né à Jérusalem en 1945, élevé dans un environnement religieux, connaissant bien la topologie des milieux de la ville sainte. Ce qui ressort d'emblée, c'est le fait que l'oeuvre dépend de la connaissance qu'a l'auteur des aspects sociaux, du mode de vie, de l'idéologie des groupes qu'il côtoie ainsi que des répercussions négatives dont il ressent les effets sur la société israélienne. Notre démarche d'analyse est la suivante : un survol rapide des tendances de la littérature israélienne à partir des années cinquante et la place qu'occupe notre romancier qui fait partie de la génération de "l'après Etat"; les motivations qui ont impulsé le travail; la caractérisation des personnages principaux et leur situation dans la trame du récit; la critique allusive des travers de la société s'exprimant par le truchement des genres littéraires de la satire, de la parodie et du pastiche; le décodage des thèmes majeurs relevant de la mystique juive et développés par le grand kabbaliste Isaac Luria (1534-1572), à savoir, entre autres, le Simsum (concentration, contraction), Shevirat ha kélim (Brisure des vases), Tiqqun (réparation, rédemption), Gilgul (transmigration). . .
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3

Bin, Raja Halid Raja Iskandar. "The Malay nobat : a history of encounters, accommodation and development." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/the-malay-nobat(d63e444f-1d28-4c1c-b613-e81b1d8567bc).html.

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Анотація:
The Malay nobat is the only court ensemble found in the Islamicate world that is still performed within its original context to serve political rulers. It symbolises power and sovereignty, and no ruler who possesses a nobat is legitimately installed unless he is dinobatkan (drummed) to its sound. Guarded as part of court regalia, the nobat is revered for its perceived mystical powers and ability to consolidate and maintain socialpolitical order (Andaya 2011). Like many musical traditions, the nobat institution is a product of a long process of encounters, shaped by interactions within and across imagined boundaries; and developed through the accommodation of different cultures and beliefs. Who brought the nobat to the Malay world and why? How was the new musical culture adopted and indigenised? What crucial role did the nobat play in the development of Malay political and social systems? Did the nobat go through a critical transition as a result of western colonisation? By setting up a dialogue between indigenous and western sources, this study situates the nobat in a wider, connected historical milieu (Subrahmanyam 2005), to find a common, multi-lateral historical thread contextualised within the Malay notion of sovereignty (Milner 1982, 2008) and communal identity (Stokes 1997). It explores the development of the nobat with reference to important themes in Malay historiography which include pre- and Islamic influences, connections with South Asia and the Middle East, political rivalry and intrigues, interregional migration, ethnicity and foreign intervention. The first chapter will explain the objectives and research questions regarding the study. Chapter Two looks back at the early Islamicate military/ceremonial band and its relations to the Malay nobat. The third chapter will introduce the current nobat ensembles, including their instruments and music. By studying the Hikayat Patani, Chapter Four explores the importance of the ensemble in a Malay sultanate in the sixteenth and seventeenth centuries. Chapter Five takes a look at another Malay court literature, the Adat Aceh and accounts of European encounters with the nobat in the seventeenth century. Chapter Six will discuss the impact British colonisation had on the nobat and the final chapter summarises the thesis with a look at the development of the ensemble and its possible future.
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4

Bouilly, Justine. "Etude de nouveaux acteurs de la physiopathologie ovarienne." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T069.

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Les données bibliographiques décrivent un nombre croissant de modèles murins caractérisés sur le plan de la fertilité permettant une meilleure compréhension du phénomène de la croissance folliculaire. Certains de ces modèles animaux, invalidés pour des facteurs de transcription reproduisent un phénotype d’infertilité, telle que l’insuffisance ovarienne primaire (IOP). La compréhension des mécanismes moléculaires des facteurs de transcription essentiels à la fonction ovarienne n’est pas clairement établie. Les protéines contenant des domaines liant l’ADN, tels que les homéodomaines ou les domaines forkhead jouent un rôle-Clé dans le développement ovarien. NOBOX (Newborn Ovary Homeobox) est un facteur de transcription essentiel à la mise en place du stock folliculaire, et dont les mutations sont responsables d’IOP. La fonction exacte de NOBOX n’est pas connue, s’il est présent dans l’ovocyte, nous montrons pour la première fois une forte expression de cette protéine dans les cellules de la granulosa des follicules primordiaux jusqu’au stade secondaire. De plus, par différentes techniques moléculaires, nous mettons en évidence une interaction entre NOBOX et un autre acteur important de la folliculogenèse FOXL2 (Forkhead box l2), contribuant à la régulation de leurs gènes cibles respectifs. Cette étude permet de mettre en lumière le rôle de NOBOX dans les cellules de granulosa. L’IOP est une pathologie touchant 1 % des femmes âgées de moins de 40 ans. Sur le plan ovarien, il y a une déplétion du stock des follicules ou un blocage de la maturation folliculaire. De ce fait, la stérilité est le plus souvent définitive. Une origine génétique de cette maladie est parfois retrouvée avec des mutations des autosomes et/ou du chromosome X, mais dans plus de 80% des cas l’IOP est idiopathique. L’enjeu est donc d’identifier de nouveaux gènes candidats pour cette pathologie. Dans cette étude nous validons la prévalence des mutations du gène NOBOX faisant de ce facteur un des gènes clés de l’IOP. Puis, à l’aide d’une nouvelle technologie : le séquençage multiplex par puces PGMTM ION TORRENT, nous mettons en évidence dans 26% de la cohorte étudiée (100 femmes atteintes d’IOP sporadique primaire ou secondaire) un défaut génétique de 10 gènes, dont 4 nouveaux candidats à l’IOP. De façon intéressante, la présence d’au moins deux gènes mutés chez 9 patientes induit un phénotype plus précoce. Cette étude contribue à une meilleure compréhension de l’origine génétique de l’IOP et met pour la première fois en évidence le phénomène d’oligogénisme chez des patientes en IOP
Single germline mutations found in women with primary ovarian insufficiency (POI), besides mouse models have provided substantial understanding into the factors involved in differentiation and ovarian development. POI is characterized by amenorrhea with elevated gonadotropin levels, and affects 1% of women before the age of 40 years.Several transcription factors involved in ovary development and folliculogenesis are mutated in reproductive disorders. We have shown a high prevalence of POI cases harboring mutations in the Newborn oogenesis homeobox (NOBOX) gene, which encodes a homeodomain-Containing transcription factor expressed preferentially in oocyte. NOBOX plays a critical role in early folliculogenesis and its absence leads to sterility. In addition to its oocyte localization, we show here that NOBOX is also expressed in granulosa cells (GCs), those surrounding the germ cell. Since NOBOX and FOXL2, a master regulator of GC development (belonging to forkhead family), are co-Expressed in GCs. Here, using several molecular approaches, we have demonstrated that NOBOX and FOXL2 indeed physically interact leading to a down-Regulation of their transactivation capacity. Altogether, these observations highlight a novel role for NOBOX in interaction with FOXL2, and suggest that they may be antagonistic transcription regulators. POI encompasses a heterogeneous spectrum of conditions, through two major mechanisms, follicle dysfunction and follicle depletion. Genetic component such as X chromosome abnormalities, deletions, FMR1 premutations, BMP15 variants, were identified as the first genetic causes of the pathophysiology. Today, the genetic origin of POI is supported by the existence of monogenic forms in humans and animal models but the relevance of several loci for POI pathogenesis should not be ruled out. By means of a next-Generation sequencing , a multiplex (PGM-Ion Torrent technology) sequencing of 19 genes was undertaken in a cohort of 100 nonsyndromic women with POI. In 26 patients, we reported 10 gene defects, among them, missense mutations in 4 new candidates were detected. Our aggregate data suggest that point mutations in these candidate genes are causative of the disease by prediction analysis assays. Two to three gene defects can synergize to produce a more severe phenotype in POI patients than either alone. This study identifies for the first time in a large proportion of POI patients specific sets of germline mutations that, together, may account for this disease. Thus, oligogenicity also has implications for genetic counseling regarding POI
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Nobst, Danny [Verfasser]. "Datenauswertung der Vierfachimpfung gegen die Humanen Papillomaviren Typ 6, 11, 16 und 18 / Danny Nobst." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1035638533/34.

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Bostoen, Karel Johan Stephan. "Dichterschap en koopmanschap in de zestiende eeuw : omtrent de dichters Guillaume de Poetou en Jan vander Noot /." Deventer : Uitg. Sub Rosa, 1987. http://catalogue.bnf.fr/ark:/12148/cb34941123g.

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7

Liu, Shengbin. "The roles of the NOOT-BOP-COCH-LIKE genes in plant development and in the symbiotic organ identity." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASB005.

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Les gènes NODULE-ROOT de Medicago truncatula, BLADE-ON-PETIOLE d’Arabidopsis thaliana et COCHLEATA de Pisum sativum font partie d'un clade spécifique NOOT-BOP-COCH-LIKE1 (NBCL1) hautement conservé et qui appartient à la famille de gènes NON-EXPRESSOR OF PATHOGENESIS RELATED PROTEIN1 LIKE. Chez les légumineuses, les membres du clade NBCL1 sont connus comme les principaux régulateurs de l'identité des organes symbiotiques (nodules). Les membres du clade NBCL2 (MtNOOT2) jouent également un rôle clé dans l'établissement et le maintien de l'identité de l’organe symbiotique, en redondance avec les gènes NBCL1. Il a également été démontré que ces gènes végétaux NBCL sont impliqués dans l'abscission. Les gènes NBCL sont également conservés chez les plantes monocotylédones chez lesquelles ils contrôlent différents aspects du développement. Ce travail de thèse vise à mieux comprendre les rôles des gènes NBCL1 et NBCL2 dans le développement des plantes légumineuses et chez Brachypodium et à découvrir de nouveaux acteurs moléculaires impliqués dans la régulation de l'identité des nodules dépendante de NBCL1, en utilisant de nouveaux mutants d'insertion TILLING et Tnt1 chez deux espèces de légumineuses (Medicago et Pisum). En outre, nous avons utilisé les mutations KO CRISPR chez Brachypodium pour mieux comprendre leur rôle chez les plantes monocotylédones. Ce travail de thèse a permis d'élucider les nouvelles fonctions des gènes NBCL1 dans le développement des tiges et l'architecture des plantes. Nous avons également révélé que les membres du clade NBCL2, spécifique aux légumineuses, fonctionnent de manière redondante avec le clade NBCL1 et jouent des rôles importants dans le développement des feuilles, des stipules, des inflorescences et des fleurs. De plus, nous avons montré un rôle dans le développement, l'établissement et le maintien de l'identité des nodosités, et par conséquent dans le succès et l'efficacité de l'association symbiotique. Dans cette thèse, nous avons également exploré les rôles des gènes NBCL BdUNICULME4 et BdLAXATUM-A, dans le développement de B. distachyon à l'aide de doubles mutants. Nous avons confirmé les résultats précédents et révélé une nouvelle fonction pour ces deux gènes dans l'architecture des plantes, la formation des ligules et des inflorescences, ainsi que dans la teneur en lignine. Ce travail de thèse a finalement permis l'identification et la caractérisation de nouveaux mutants pour les gènes de M. truncatula ALOG (Arabidopsis LSH1 et Oryza G1). Les protéines ALOG sont des partenaires d'interaction potentiels pour les NBCLs. Nous avons montré que certains membres ALOG jouent un rôle important dans le développement des nodules et des organes aériens. Dans l'ensemble, ce travail de thèse suggère qu'au cours de l'évolution, le programme de développement des nodules a été recruté à partir de programmes de régulation préexistants pour le développement et l'identité des nodosités
The Medicago truncatula NODULE-ROOT, the Arabidopsis thaliana BLADE-ON-PETIOLE, and the Pisum sativum COCHLEATA genes are members of a highly conserved NOOT-BOP-COCH-LIKE1 (NBCL1) specific clade that belongs to the NON-EXPRESSOR OF PATHOGENESIS RELATED PROTEIN1 LIKE gene family. In legumes, the members of this NBCL1 clade are known as key regulators of the symbiotic organ identity. The members of the NBCL2 clade (MtNOOT2) also play a key role in the establishment and maintenance of the symbiotic nodule identity, redundantly with NBCL1 while without significant phenotype alone. These NBCL plant genes were also shown to be involved in abscission. In addition, NBCL genes are also conserved in monocotyledon plants in which they also control different aspects of development. The present thesis work aims to better understand the roles of the NBCL1 and NBCL2 genes in development in both legume and Brachypodium plants and to discover new molecular actors involved in the NBCL1-dependent regulation of the nodule identity using novel TILLING and Tnt1 insertional mutants in two legume species, Medicago, and Pisum. In addition we used CRISPR knock-out mutations in Brachypodium to better understand their roles in monocotyledon plants. This thesis work unraveled new functions of the NBCL1 genes in plant shoot development and plant architecture. We also revealed that the members of the legume-specific NBCL2 redundantly function with NBCL1 sub-clade and play important roles in leaf, stipule, inflorescence and flower development. In addition we showed a role in nodule development, identity establishment and maintenance, and consequently in the success and efficiency of the symbiotic association. In this thesis, we also explored the roles of the highly conserved NBCL genes, BdUNICULME4 and BdLAXATUM-A, in the development of B. distachyon using double mutants. We confirmed previous results and reveal a new function for these two genes in plant architecture, ligule and inflorescence formation, and also lignin content. This thesis work has finally allowed the identification and the characterization of new mutants for M. truncatula ALOG (Arabidopsis LSH1 and Oryza G1) genes. ALOG proteins are potential interacting partners for NBCL. We showed that some ALOG members play important roles in nodule and aerial organ development. Altogether, this thesis work suggests that during evolution, the nodule developmental program was recruited from pre-existing regulatory programs for nodule development and identity
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Magne, Kévin. "The roles of the NOOT-BOP-COCH-LIKE genes in the symbiotic organ identity and in plant development." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS482/document.

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L’association symbiotique entre les légumineuses et les rhizobia aboutit à la formation de la nodosité fixatrice d’azote. Cet organe symbiotique généré de-novo permet l’hébergement intracellulaire des rhizobia qui, grâce à leurs activités nitrogénase,réduisent l’azote atmosphérique en ammonium, une forme de l’azote directement assimilable par la plante hôte.Les mécanismes moléculaires sous-jacents à la reconnaissance entre les deux partenaires symbiotiques, au processus d’infection et à l’organogénèse de la nodosité sont bien décrits, cependantl’établissement et la maintenance de l’identité de cet unique organe souterrain restent incompris.Les gènes NODULE-ROOT de Medicago truncatula, BLADEON-PETIOLE d’Arabidopsis thaliana et COCHLEATA de Pisumsativum sont membres du clade spécifique très conservé NOOTBOP-COCH-LIKE1 (NBCL1) qui fait partie de la famille des gènesNON-EXPRESSOR OF PATHOGENESIS RELATED PROTEIN1-LIKE. Chez les légumineuses, les membres de ce clade NBCL1 sont connus comme étant des régulateurs clés de l’identité de l’organe symbiotique.Mon travail de thèse a eu pour but d’améliorer la compréhension des rôles des gènes NBCL1, à la fois chez des espèces formant des nodosités indéterminées et déterminées, ainsi que de découvrir de nouveaux acteurs moléculaires impliqués dans l’identité de la nodosité dont la régulation est dépendante des gènesNBCL1, essentiellement par l’utilisation de mutants TILLING, Tnt1et LORE1 originaux chez trois espèces de légumineuses: la luzerne tronquée, le petit pois et le lotier.Ce travail rapporte essentiellement l’identification et la caractérisation de nouveaux mutants affectés dans des gènes qui font partie d’un second sous-clade NBCL2 spécifique des légumineuses.Nous avons révélé que les membres de ce sous-clade spécifique des légumineuses NBCL2 jouent d’importants rôles dans le développement de la nodosité, dans l’établissement et la maintenance de l’identité de la nodosité et par conséquence dans le succès et l’efficacité de l’association symbiotique.Ce travail suggère aussi qu’au cours de l’évolution, le programme de développement de la nodosité a recruté des mécanismes de régulations préexistants afin de réguler le développement de la nodosité et son identité, tel que le module de régulation impliquant des interactions entre des protéines NBCL et des facteurs de transcriptions basic leucine zipper de type TGACG. Nous avons identifié le facteur de transcription MtPERIANTHIA-LIKE, comme un premier partenaire protéique interagissant avec des protéines NBLC dans un contexte de nodosité symbiotique. Les gènes NBCL sont aussi impliqués dans les réseaux de régulations qui contrôlent le développement et le déterminisme de nombreux organes végétatifs et reproductifs aériens et sont également impliqués dans la capacité d’abscission de ces organes.Finalement, ce travail thèse a eu pour objectif d’explorer les rôles de ces gènes NBCL très conservés, dans le développement de la graminée non-domestiquée, Brachypodium distachyon
The symbiotic interaction between legumes andrhizobia results in the formation of a symbiotic nitrogen fixingnodule.This de-novo generated symbiotic organ allows the intracellularaccommodation of the rhizobia which reduces through theirnitrogenase activity the atmospheric nitrogen in ammonium, anitrogen form usable by the host plant.The molecular mechanisms underlying the symbiotic partnersrecognition, the infection process and the nodule organogenesis arewell described, however the identity establishment and maintenanceof this unique underground organ remain mis-understood.The Medicago truncatula NODULE-ROOT, the Arabidopsisthaliana BLADE-ON-PETIOLE and the Pisum sativumCOCHLEATA genes are members of a highly conserved NOOTBOP-COCH-LIKE1 (NBCL1) specific clade that belongs to theNON-EXPRESSOR OF PATHOGENESIS RELATED PROTEIN1-LIKE gene family. In legumes, the members of this NBCL1 cladeare known as key regulators of the symbiotic nodule identity.The present thesis work aims to better understand the roles of theNBCL1 genes, in both indeterminate and determinate nodule formingspecies and to discover new molecular actors involved in theNBCL1-dependent regulation of the nodule identity essentially usingnovel TILLING, Tnt1 and LORE1 insertional mutants in three legumespecies, Medicago, Pisum and Lotus.This thesis work has allowed the identification and thecharacterization of new mutants for genes belonging to a secondarylegume-specific NBCL2 sub-clade. We revealed that the members ofthis legume-specific NBCL2 sub-clade play important roles in noduledevelopment, identity establishment and maintenance, andconsequently in the success and in the efficiency of the symbioticassociation.This thesis work also shows that during evolution, the noduledevelopmental program has recruited pre-existing regulatorymechanisms for the nodule development and identity, such as theregulatory module involving interactions between NBCL proteins andTGACG type basic leucine zipper transcription factors. We identifiedthe transcription factor, MtPERIANTHIA-LIKE, as a first interactingpartner of NBCL proteins in a context of root nodule symbiosis.NBCL genes are also involved in the regulatory networks thatcontrol the development and the determinacy of many abovegroundvegetative and reproductive organs and were also shown as involvedin their abscission ability.In this thesis we also explored the roles of these highly conservedNBCL genes in the development of the non-domesticated grass,Brachypodium distachyon
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Noboa, Campana Eduardo [Verfasser], and Harald [Akademischer Betreuer] Heinrichs. "Designing knowledge-action networks for supporting energy focused sociotechnical change in illiberal democracies : Designing knowledge-action networks for supporting energy focusedsociotechnical change in illiberal democracies:Interfacing science, policy and transformation processes towards sustainability in Andean Countries / Eduardo Noboa Campana ; Betreuer: Harald Heinrichs." Lüneburg : Universitätsbibliothek der Leuphana Universität Lüneburg, 2019. http://d-nb.info/1191479544/34.

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Noboa, Campana Eduardo Verfasser], and Harald [Akademischer Betreuer] [Heinrichs. "Designing knowledge-action networks for supporting energy focused sociotechnical change in illiberal democracies : Designing knowledge-action networks for supporting energy focusedsociotechnical change in illiberal democracies:Interfacing science, policy and transformation processes towards sustainability in Andean Countries / Eduardo Noboa Campana ; Betreuer: Harald Heinrichs." Lüneburg : Universitätsbibliothek der Leuphana Universität Lüneburg, 2019. http://nbn-resolving.de/urn:nbn:de:gbv:luen4-opus-145554.

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Книги з теми "Nobot"

1

Chohap, Kyŏnghyang Sinmunsa Nodong. Kyŏnghyang nobo. [Seoul]: Kyŏnghyang Sinmunsa Nodong Chohap, 1991.

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Zwerver, Imro. Un horizonte nobo. Kòrsou: Rudy Rooi, SeAK, 1990.

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3

Bakhuis, Gilberto S. Un bido nobo. [Netherland Antilles: s.n.], 1996.

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Guṇavardhana, Pī Es Ḍabliv. Akaradāruva, nohot, Ḍārli Vijēvīragē andaraya. Koḷamba: As. Godage, 2010.

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Jayasēna, Henri. "Bālha gilānō" nohot rōgiyekugē katāvak. Koḷamba: Ăs. Goḍagē saha Sahōdarayō, 1999.

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Candrasiri, Jayanta. Akāla sandhyā nohot kālatrayē tīrtha yātrikayā. Pannipiṭiya: Sṭămfarḍ Lēk, 2000.

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Buckinx, Boudewijn. Aria van de diepe noot: Verzamelde commentaren. Peer [Belgium]: Alamire, 2001.

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Bruyns, R. A. Mörzer. Met noot MB: 1974-1994 : annotaties onteigeningsrecht. Zwolle: W.E.J. Tjeenk Willink, 1995.

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9

Nobo-san: Shōsetsu Masaoka Shiki to Natsume Sōseki. Tōkyō: Kōdansha, 2013.

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10

Noboa, Fernando Jurado. Los Noboa de la sierra: Estudio histórico-genealógico, sociológico y sicodinámico. Quito, Ecuador: [Sociedad Amigos de la Genealogía], 1985.

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Частини книг з теми "Nobot"

1

De Groot, H. "Een Gevaarlijke Noot." In Casusboek allergie, 21. Houten: Bohn Stafleu van Loghum, 2012. http://dx.doi.org/10.1007/978-90-313-9902-4_11.

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de Groot, H. "Een Gevaarlijke Noot." In Casusboek allergie, 68–69. Houten: Bohn Stafleu van Loghum, 2012. http://dx.doi.org/10.1007/978-90-313-9902-4_43.

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Wiedenstried, Holger E. "Noot, Jan van der." In Kindlers Literatur Lexikon (KLL), 1. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_12797-1.

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Schäfer, Wilfried. "Noot, Jan van der: Cort begrijp der XII boecken Olympiados." In Kindlers Literatur Lexikon (KLL), 1–2. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_12798-1.

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Couzigou, Jean-Malo, and Pascal Ratet. "NOOT-Dependent Control of Nodule Identity: Nodule Homeosis and Merirostem Perturbation." In Biological Nitrogen Fixation, 487–98. Hoboken, NJ, USA: John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781119053095.ch49.

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Dechamps, Xavier, and Stefan Hein. "Extension of the PSE Code NOLOT for Transition Analysis in Rotating Reference Frames." In Notes on Numerical Fluid Mechanics and Multidisciplinary Design, 179–88. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64519-3_16.

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Daly, M. "JAN VAN DER NOOT A THEATRE FOR WORLDLINGS (LONDON: HENRY BYNNEMAN, 1569)." In English Emblem Tradition, 1–28. Toronto: University of Toronto Press, 1987. http://dx.doi.org/10.3138/9781442674509-003.

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8

Maquieira Rodriguez, Marina. "La Nueva Gramática de la lengua Castellana de Martínez de Noboa: La coherencia interna de una doctrina." In History of Linguistics in Spain/Historia de la Lingüística en España, 301. Amsterdam: John Benjamins Publishing Company, 2001. http://dx.doi.org/10.1075/sihols.100.20maq.

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9

"Noboa Bejarano, Gustavo (Ecuador)." In The Statesman’s Yearbook Companion, 282–83. London: Palgrave Macmillan UK, 2019. http://dx.doi.org/10.1057/978-1-349-95839-9_562.

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10

"Noot van de vertaler." In Religie, 165. Routledge, 2003. http://dx.doi.org/10.4324/9780203217337-5.

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Тези доповідей конференцій з теми "Nobot"

1

Graf, Bettina, Maike Krüger, Felix Müller, Alexander Ruhland, and Andrea Zech. "Nombot." In MUM '15: 14th International Conference on Mobile and Ubiquitous Multimedia. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2836041.2841208.

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Dijk, Jelle van, Jirka van der Roest, Remko van der Lugt, and Kees C. J. Overbeeke. "NOOT." In the 8th ACM conference. New York, New York, USA: ACM Press, 2011. http://dx.doi.org/10.1145/2069618.2069646.

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Marabelle, Aurelien, Jean-Francois Baurain, Ahmad Awada, Rebbecca S. Kristeleit, Delphine Loirat, Dag E. Jossang, Nina L. Jebsen, et al. "Abstract CT069: A Phase I study of the oncolytic peptide LTX-315 generatesde novoT-cell responses and clinical benefit in patients with advanced melanoma." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-ct069.

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Baaurain, Jean-Francois, Christiane Jungels, Rebecca S. Kristeleit, Dag E. Jossang, Nina L. Jebsen, Øystein Rekdal, Baldur Sveinbjornsson, et al. "Abstract CT010: A phase I study of the oncolytic peptide LTX-315 generatesde novoT-cell responses and clinical benefit in patients with advanced sarcoma." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-ct010.

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Baaurain, Jean-Francois, Christiane Jungels, Rebecca S. Kristeleit, Dag E. Jossang, Nina L. Jebsen, Øystein Rekdal, Baldur Sveinbjornsson, et al. "Abstract CT010: A phase I study of the oncolytic peptide LTX-315 generatesde novoT-cell responses and clinical benefit in patients with advanced sarcoma." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-ct010.

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Marabelle, Aurelien, Jean-Francois Baurain, Ahmad Awada, Rebbecca S. Kristeleit, Delphine Loirat, Dag E. Jossang, Nina L. Jebsen, et al. "Abstract CT069: A Phase I study of the oncolytic peptide LTX-315 generatesde novoT-cell responses and clinical benefit in patients with advanced melanoma." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-ct069.

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