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Добірка наукової літератури з теми "Neoplasie solide"

Автор: Grafiati

Опубліковано: 11 березня 2023

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Статті в журналах з теми "Neoplasie solide"

1

Boehm, A., A. Dietz, and I. S. Horn. "Solide kindliche Speicheldrüsentumoren." Kinder- und Jugendmedizin 13, no. 02 (2013): 97–105. http://dx.doi.org/10.1055/s-0038-1629326.

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ZusammenfassungSchwellungen der Speicheldrüsen treten bei Kindern häufig auf, wahre solide Speicheldrüsentumoren sind dagegen sehr selten. Die meisten dieser Tumoren treten erst im Alter zwischen 7 und 16 Jahren auf. Die Diagnostik erfolgt neben der klinischen Untersuchung mittels Sonografie, Magnetresonanz- oder Computertomografie.Bei Kindern ist das relative Risiko, dass es sich bei einem Speicheldrüsentumor um ein Malignom handelt, deutlich höher als beim Erwachsenen. Die häufigste gutartige Neoplasie ist das pleomorphe Adenom. Das häufigste Malignom ist das Mukoepidermoidkarzinom. Beide Tumoren treten v. a. in der Glandula parotis auf. Therapie der Wahl ist die operative Resektion des Tumors mit ausreichendem Sicherheitsabstand. Bei Malignomen ist eine Neck dissection bei radiologisch nachgewiesener Lymphknotenmetastasierung oder zusätzlichen Risikofaktoren notwendig. Die Indikation zu einer adjuvanten Radiatio sollte vorsichtig als individuelle Entscheidung getroffen werden.

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2

Klausenitz, Catharina, Anika Pusch, and Birger Mensel. "Solide pseudopapilläre Neoplasie des Pankreas beim Mann mit Ikterus – eine seltene Differentialdiagnose zystischer Pankreasläsionen." TumorDiagnostik & Therapie 40, no. 03 (April 2019): 196–97. http://dx.doi.org/10.1055/a-0870-9037.

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3

Klausenitz, Catharina, Anika Pusch, and Birger Mensel. "Solide pseudopapilläre Neoplasie des Pankreas beim Mann mit Ikterus – eine seltene Differentialdiagnose zystischer Pankreasläsionen." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 190, no. 07 (February 7, 2018): 637–38. http://dx.doi.org/10.1055/s-0044-101262.

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4

Honauer, Prim, and Goetschel. "Der kindliche Thymus im Thoraxröntgenbild: Wenn Schiffssegel und Engelsflügel nicht weiterhelfen." Praxis 96, no. 23 (June 1, 2007): 937–39. http://dx.doi.org/10.1024/1661-8157.96.23.937.

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Das Thoraxröntgenbild eines sechs Monate alten Jungen mit Fieber und Husten zeigt ein retrokardial linksseitiges pneumonisches Infiltrat und bilaterale solide Transparenzminderungen unklarer Ätiologie. Nach klinisch erfolgreicher antibiotischer Therapie zeigt sich im Kontroll-Röntgenbild eine vollständige Auflösung der Konsolidation retrokardial bei persistierenden bilateralen Verschattungen. In der in der Folge durchgeführten Computertomographie fand sich ein ungewöhnlich konfigurierter Thymus von homogener, normaler Struktur. Die Organgrenzen des kindlichen Thymus sind konventionell-radiologisch oft sehr schwer oder gar nicht von den benachbarten anatomischen Strukturen abzugrenzen. Das Organ weist eine grosse interindividuelle Variabiliät bezüglich Form und Grösse auf und kann eine intrathorakale Neoplasie imitieren. Oft wird zur konklusiven Beurteilung der Einsatz von Schnittbildverfahren notwendig.

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5

Buse, Lurati, and Schmid. "Hodentumoren – eine aktuelle Übersicht." Praxis 92, no. 47 (November 1, 2003): 1989–97. http://dx.doi.org/10.1024/0369-8394.92.47.1989.

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Hodentumoren machen 1% der Tumoren beim Mann aus, stellen aber die häufigste solide Neoplasie des jungen Mannes dar. Als Risikofaktoren sind hauptsächlich der Kryptorchismus und eine positive persönliche Hodentumor-Anamnese zu erwähnen. Histologisch wird zwischen Keimzell- und Nichtkeimzelltumoren unterschieden, wobei letztere ungefähr 5% aller Hodentumoren darstellen. Die Keimzelltumoren werden ihrerseits in der Klinik in zwei Untergruppen unterteilt: Seminome und Nichtseminome. Die häufigste klinische Erstmanifestation ist eine schmerzlose Induration. Zur Basisdiagnostik gehören die Sonographie und die Bestimmung von Tumormarkern. Der erste therapeutische Schritt ist die inguinale Semikastratio. Die weiteren therapeutischen Optionen erfolgen stadiengerecht: sie beinhalten Radiotherapie, Chemotherapie aber auch abwartende Beobachtung. Prognostisch zeichnen sich Hodentumoren durch ihre gute Heilungsrate (98–100% in frühen Stadien) oder langes rezidivfreies Überleben (80–90% in späteren Stadien) aus.

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6

Oliva, Fernando Cascelli, Gabriel José Dos Santos, Gustavo Hideki Hideki Orikasa, Milena Martello Cristófalo, Rafael Reis dos Santos, Beatriz Souza dos Santos, Felipe Giacobo Nunes, et al. "Tumor de Frantz: desafios diagnósticos e terapêuticos: relato de caso / Frantz’s tumor: diagnostic and therapeutic challenges: case report." Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo 64, no. 1 (May 6, 2019): 65. http://dx.doi.org/10.26432/1809-3019.2019.64.1.065.

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Introdução: O tumor sólido pseudopapilar do pâncreas ou Tumor de Frantz, é uma neoplasia rara, que acomete preferencialmente mulheres jovens e apresenta bom prognóstico, com baixas taxas de mortalidade. Relato de Caso: O presente trabalho apresenta um caso de uma paciente da Santa Casa de São Paulo, com Tumor de Frantz, seu diagnóstico, tratamento e complicações pós pancreatectomia.Descritores: Pâncreas, Neoplasias pancreáticas, Carcinoma papilar, Pseudocisto pancreático, Fístula pancreáticaAbstractIntroduction: The solid pseudopapillary tumor, or Frantz’s tumor, is a rare neoplasm that occurs mainly in young women and have a good prognosis, with a low mortality rate. Case report: This study aims to describe the diagnosis, treatment and post pancreatectomy complications of a Frantz’s tumor case in Santa Casa of São Paulo.Keywords: Pancreas, Pancreatic neoplasms; Carcinoma, pappilary; Pancreatic pseudocyst; Pancreatic fistula

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7

Bonaldi, G. "La Neuroradiologia interventistica nella patologia del basicranio." Rivista di Neuroradiologia 13, no. 3 (June 2000): 495–507. http://dx.doi.org/10.1177/197140090001300317.

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Il basicranio è sede di una grande varietà di eventi patologici; la sua complessità anatomica condiziona una difficile accessibilità terapeutica, in particolare chirurgica. La neuroradiologia interventistica diviene quindi strumento di grandi utilità e versatilità, potendo da un lato intervenire a supporto del chirurgo, con tecniche di embolizzazione preoperatoria, dall'altro potendo realizzare trattamenti definitivi di lesioni non altrimenti aggredibili. Le lesioni neoplastiche di interesse neurointervenzionistico che più frequentemente coinvolgono tale distretto sono: - i meningiomi, tendenzialmente meno ipervascolari rispetto a quelli della volta, possono beneficiare di un'embolizzazione preoperatoria, in tal caso solitamente realizzata con particelle solide di piccole dimensioni. L'obiettivo è quello di ottenere una devascolarizzazione il più radicale e il più distale possibile; per tale motivo vengono utilizzate particelle anche di diametro medio inferiore ai cento micron, le particelle più usate sono di P.V.A. (gelatina di alcol di polivinile), la tecnica è quella della microcateterizzazione iperselettiva dei rami durali afferenti. Spesso l'asportazione radicale di neoplasie della base cranica (tipicamente i meningiomi della regione cavernosa) non può prescindere da una dissecazione del tumore dalle pareti dall'arteria carotide interna, con conseguente rischio intraoperatorio di lesione od occlusione della stessa. In questi casi diventa importante l'esecuzione preoperatoria di un test d'occlusione per valutare i circoli di compenso. - I chemodectomi sono tumori ipervascolari, pressoché ubiquitari ma la cui sede più frequente è rappresentata dalla regione timpano-giugulare. Una loro asportazione chirurgica totale, che può condurre alla completa guarigione, non può assolutamente prescindere da una devascolarizzazione preoperatoria mediante embolizzazione. Quest'ultima può essere realizzata sia con particelle solide, sia con colle acriliche. - L'angiofibroma giovanile naso-faringeo è una lesione neoplastica benigna, modicamente vascolarizzata, originante a livello del forame sfeno palatino, spesso con coinvolgimento verso l'alto delle regioni etmoidali e del basicranio anteriore, con apporti al circolo patologico neoformato originanti dai sifoni carotidei o dalle arterie oftalmiche, di difficile embolizzazione per via endovascolare con tecnica di microcateterismo; la neoplasia può quindi essere embolizzata mediante puntura diretta (attraverso orifici naturali o per via percutanea) e successiva iniezione di colla acrilica. Alcune malformazioni vascolari che coinvolgono il basicranio sono di particolari interesse terapeutico mediante gli approcci endovascolari della neuroradiologia interventistica. Gli aneurismi del sifone carotideo intracavernoso, che solitamente si rendono evidenti clinicamente quando raggiungono le dimensioni dell'aneurisma gigante, possono essere trattati mediante embolizzazione selettiva con spirali di Guglielmi e risparmio dell'arteria portante; più frequentemente per il loro trattamento è necessario il sacrificio dell'asse carotideo interno, mediante occlusione con palloncini staccabili previo test d'occlusione. Le fistole carotido cavernose dirette sono più spesso di natura post-traumatica, meno frequentemente da rottura di aneurisma intracavernoso, da collagenopatia, da displasia fibro-muscolare. Il trattamento endovascolare è particolarmente elegante, e uno dei primi trattamenti eseguiti a livello intracranico per via endovascolare. La tecnica consiste nel ripristinare la normale pervietà dell'arteria carotide interna, occludendo il tramite patologico, mediante gonfiaggio di un palloncino staccabile nel versante venoso. Solo nelle lesioni traumatiche più gravi, con lacerazioni irregolari o multiple della parete arteriosa, può essere necessario il sacrificio della stessa. È possibile in casi selezionati anche un trattamento per via venosa, mediante stipamento del seno cavernoso con spirali staccabili di Guglielmi. Le fistole durali più frequenti sono a livello della loggia cavernosa e delle regioni dei seni trasverso e sigmoideo. Esse possono essere trattate mediante embolizzazione degli apporti arteriosi durali, con particelle solide oppure con con colle acriliche; è possibile anche un approccio per via venosa a livello di un seno durale di scarico, solitamente occluso per pregresso evento trombotico, e successivo stipamento con spirali metalliche. Nei casi ritenuti chirurgici, con clippaggio dell'origine delle vene di scarico intracraniche, l'embolizzazione preoperatoria può ridurre il rischio dell'intervento diminuendo la pressione nelle strutture venose.

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8

Andreula, F. C., A. M. N. Recchia-Luciani, and L. Garofalo. "Linfomi del sistema nervoso centrale e Aids." Rivista di Neuroradiologia 10, no. 2_suppl (October 1997): 206. http://dx.doi.org/10.1177/19714009970100s292.

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I linfomi del sistema nervoso centrale, a lungo eteroplasie intracraniche rare (1–2%) sono in continuo aumento percentuale in relazione con l'immunodepressione virale dell' AIDS (6% dei pazienti, 3% in età pediatrica), così come con quella iatrogena. Tipiche dei linfomi AIDS l'associazione con l'EB virus, l'elevata malignità, la scarsa risposta alla terapia, la localizzazione (SNC, midollo, intestino, cute, anoretto). Oggi tali tumori sono riscontrati in tutte le età (60 anni è la decade di presentazione tipica negli immunocompetenti). Le forme intracraniche, soprattutto B (80%), sono l'1% dei Non-Hodgkin, e dovrebbero essere considerate in realtà secondarie, dal punto di vista fisiopatologico, anche nei casi in cui l'esordio riguardi il SNC. Dal 20 al 40% dei casi sono forme multiple. Il ruolo giocato dall'Imaging deve essere considerato importante, poiché, nonostante le frequenti recidive a breve termine (la sopravvivenza media dalla diagnosi supera di poco l'anno, ed è minore nell'AIDS), queste forme rispondono, quando correttamente inquadrate, assai bene alle alte dosi di cortisonici (nel 40% dei soggetti trattati, già in 24 ore, per linfolisi e ripristino della b.e.e.) così come alla radioterapia. Nella patogenesi sono invocati differenti meccanismi di interconnessione tra neoplasie e agenti virali. La sede preferenziale è sopratentoriale in regione dei nuclei della base o comunque in strutture in cui la componente prevalente è la sostanza bianca. L'estensione dell'edema è incongrua rispetto all'entità della lesione, in ragione della esigua neoangiogenesi indotta. Queste masse hanno margini relativamente ben definiti solo macroscopicamente, con ben maggiore infiltrazione all'istologia; foci di rammollimento necrotico o emorragico sono rari nei pazienti AIDS. All'istologia la zona centrale di cellularità elevata, più rarefatta in periferia, mostra un caratteristico aspetto a “bulbo di cipolla” della trama reticolare. Queste neoplasie si localizzano a livello degli “involucri” cerebrali: sedi caratteristiche sono infatti le leptomeningi e le aree lungo lo spazio subependimal (40–50%), aree di coinvolgimento rese manifeste dalla impregnazione del m.d.c. L'impregnazione lungo le pareti ventricolari suggerisce la diagnosi specie se le immagini RM rivelano l'ulteriore diffusione delle localizzazione leptomeningee lungo gli spazi perivascolari di Virchow Robin. Questi tumori metastatizzano per via ematica, determinando la comparsa di lesioni parenchimali, leptomeningee e meningo-durali. In sede meningo-durale un notevole infiltrato linfomatoso può assumere aspetto a lente biconvessa. Non esistono significative differenze di imaging tra forme linfomatose primitive e secondarie del S.N.C. La TC dimostra lesioni solide singole o multiple, rotondeggianti, isodense al parenchima, (nel 20% dei casi iperdense) con quasi costante accentuazione dopo m.d.c., raramente solo periferica. La RM dimostra isoiperintensità in T1, modesto incremento in DP e ipointensità rispetto alla grigia in T2, da scarso citoplasma delle cellule componenti. L'impregnazione è unicamente da alterazione della barriera emato-encefalica (scarsa la componente neovascolare).

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9

BRUNI, L., J. M. BAYAS, A. VILELLA, and A. CONESA. "Vaccination coverage in adults undergoing splenectomy: evaluation of hospital vaccination policies." Epidemiology and Infection 134, no. 4 (December 22, 2005): 837–44. http://dx.doi.org/10.1017/s0950268805005704.

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Vaccination coverage in 595 adult patients undergoing total splenectomy in the Hospital Clinic of Barcelona during 1992–2002 was studied. The rates of cover for pneumococcal, Haemophilus influenzae type b and meningococcal vaccines were 63, 63 and 61% respectively, during 2000–2002; 32, 17 and 22% in 1997–1999; and 24, 9 and 8% in 1992–1996. Multivariate analysis showed a greater risk of no vaccination in splenectomies due to trauma, malignant neoplasms of solid organs and incidental splenectomy compared with both neoplastic and non-neoplastic haematological disease, and those patients undergoing splenectomy before 2001. Coverage ([ges ]1 vaccine) since 1997 in patients with haematological diseases was 83·5% (71/85), haematological neoplasias 69·2% (18/26), solid organ neoplasms 38·3% (36/94), incidental splenectomy 35·6% (16/45), and traumas 28·4% (21/74). Mandatory hospital admission of patients undergoing splenectomy offers a good opportunity for vaccination of these patients. Specific vaccination policies should be developed to take advantage of this circumstance.

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10

Basturk, Olca, Ipek Coban, and N. Volkan Adsay. "Pancreatic Cysts: Pathologic Classification, Differential Diagnosis, and Clinical Implications." Archives of Pathology & Laboratory Medicine 133, no. 3 (March 1, 2009): 423–38. http://dx.doi.org/10.5858/133.3.423.

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Abstract Context.—Cystic lesions of the pancreas are being recognized with increasing frequency and have become a more common finding in clinical practice because of the widespread use of advanced imaging modalities and the sharp drop in the mortality rate of pancreatic surgery. Consequently, in the past 2 decades, the nature of many cystic tumors in this organ has been better characterized, and significant developments have taken place in the classification and in our understanding of pancreatic cystic lesions. Objective.—To provide an overview of the current concepts in classification, differential diagnosis, and clinical/biologic behavior of pancreatic cystic tumors. Data Sources.—The authors' personal experience, based on institutional and consultation materials, combined with an analysis of the literature. Conclusions.—In contrast to solid tumors, most of which are invasive ductal adenocarcinomas with dismal prognosis, cystic lesions of the pancreas are often either benign or low-grade indolent neoplasia. However, those that are mucinous, namely, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms, constitute an important category because they have well-established malignant potential, representing an adenoma-carcinoma sequence. Those that are nonmucinous such as serous tumors, congenital cysts, lymphoepithelial cysts, and squamoid cyst of pancreatic ducts have no malignant potential. Only rare nonmucinous cystic tumors that occur as a result of degenerative/necrotic changes in otherwise solid neoplasia, such as cystic ductal adenocarcinomas, cystic pancreatic endocrine neoplasia, and solid-pseudopapillary neoplasm, are also malignant and have variable degrees of aggressiveness.

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Більше джерел

Дисертації з теми "Neoplasie solide"

1

Letsch, Anne [Verfasser]. "Entwicklung therapeutischer Peptid-Vakzinierung zur Behandlung von Patienten mit hämatopoetischen und soliden Neoplasien / Anne Letsch." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1026694728/34.

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2

Weigert, Martin [Verfasser], and Michael [Akademischer Betreuer] Pfreundschuh. "Die Bedeutung von SUMOyliertem HSP90 bei hämatologischen Neoplasien und soliden Tumoren / Martin Weigert ; Betreuer: Michael Pfreundschuh." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2016. http://d-nb.info/1152095277/34.

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3

Siebolts, Udo [Verfasser], A. [Gutachter] Hartmann, and W. [Gutachter] Weichert. "Molekulare Charakterisierung und Diagnostik ausgewählter hämatologischer und solider maligner Neoplasien / Udo Siebolts ; Gutachter: A. Hartmann, W. Weichert." Halle (Saale) : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2019. http://d-nb.info/1210728095/34.

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4

Philipp, Julia [Verfasser]. "Expressionsmuster von FLI1, DKK1, INPP5D und BCL9 in der solid pseudopapillären Neoplasie, dem duktalen Adenokarzinom sowie der intraduktal papillär-muzinösen Neoplasie des Pankreas und deren möglicher Zusammenhang mit dem Wnt/β-Catenin-Signalweg / Julia Philipp". Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/1197055274/34.

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5

Perniß, Elisabeth [Verfasser], and V. [Akademischer Betreuer] Kunzmann. "Verhalten von verschiedenen Lymphozytenpopulationen und Lymphozytenrezeptoren bei hämatologischen Neoplasien und soliden Tumoren : Untersuchungen in vivo / Elisabeth Perniß. Betreuer: V. Kunzmann." Würzburg : Universitätsbibliothek der Universität Würzburg, 2011. http://d-nb.info/1017042934/34.

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6

Hentschke, Patrik. "Anti-tumour effect in solid tumours, tolerance and immune reconstitution after allogeneic haematopoietic stem cell transplantation /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-800-9/.

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7

Grabau, Astrid [Verfasser]. "Immunhistochemische Studie an solid-pseudopapillären Neoplasien des Pancreas in Hinblick auf molekulargenetische Veränderungen auf dem Chromosom 11Q und im Wnt-Signalweg / Astrid Grabau." Kiel : Universitätsbibliothek Kiel, 2012. http://d-nb.info/1020283548/34.

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8

TORNIERI, PAULA H. "Expressao de endostatina em fibroblastos murinos para tratamento de tumores solidos." reponame:Repositório Institucional do IPEN, 2003. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11126.

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Анотація:

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Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

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9

Fagan, Erin A. "Identification of the presence and activity of the JAK-STAT pathway in canine solid tumors." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/100859.

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Background: The JAK-STAT pathway is a cellular signaling pathway, which acts normally in humans and animals in the control of multiple important functions. Dysregulation of this pathway has been identified in human cancers, as well as a limited number of veterinary cancers. Objectives: The aims of this study were to identify the presence and tentative activity of components of the JAK-STAT pathway in selected canine tumors. Methods: Formalin-fixed, paraffin-embedded samples from mast cell tumors (MCT), hemangiosarcomas (HSA), thyroid carcinomas, and apocrine gland anal sac adenocarcinomas (AGASACA) were obtained from the Diagnostic Histopathology Laboratory at the Virginia Maryland College of Veterinary Medicine. Immunohistochemistry was performed to evaluate protein levels of JAK1, phospho-JAK1, JAK2, phospho-JAK2, STAT3, and phospho-STAT3. Signalment, treatment information, and survival information was obtained from the medical record for each case. Results: Tumor samples were scored for percent positive neoplastic cells. Positive staining was seen for all antibodies in all tumor types, with expression of JAK1, STAT3, and pSTAT3 being highest overall for all tumor types. Significant associations were seen between JAK1 and survival time in MCT (p = 0.03), pJAK1 and survival time in HSA (p = 0.009) and MCT (p = 0.04), and pSTAT3 and metastasis in MCT (p = 0.0008). Conclusions: The finding of positive staining for the components of the JAK-STAT pathway in the tumor samples evaluated indicates presence and tentative activity of this pathway in the studied cancers. Further study of JAK1, pJAK1, and pSTAT3 should be pursued to evaluate their potential as therapeutic targets.
MS

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10

Puxty, Kathryn Ann. "The characteristics and outcomes of patients with solid tumours admitted to Intensive Care in the West of Scotland." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8910/.

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Cancer is one of the commonest conditions among patients admitted to Intensive Care Units (ICU). However, little is known about how it affects likelihood of ICU admission and subsequent clinical progress. What literature does exist is often not generalisable to current UK practice. The aims of the studies presented in this thesis are to determine the features that are associated with ICU admission in patients with solid tumours; to describe how the solid tumour population in ICU differs from the ICU population without cancer; how this impacts upon survival; and finally, to describe the long-term outcomes of solid tumour patients that have survived ICU and those features associated with mortality. I undertook a detailed systematic review of the international literature relating to survival following ICU admission for patients with solid tumours. This revealed a paucity of high quality studies and led to recommendations for improving the conduct and reporting of future research in this field. Using retrospective cohorts from prospectively collected databases, variables relating to patients in the West of Scotland diagnosed with a cancer between 1st January 2000 and 31st December 2009 were analysed. The rate of ICU admission within two years following cancer incidence was investigated, and the factors associated with admission described. The Scottish Intensive Care Society Audit Group (SICSAG) database was used to detail information pertaining to critical illness and to provide data on patients without an underlying tumour that were admitted to ICU during the same study period. Three cohorts were defined: patients with a solid tumour that were admitted to ICU, patients with a solid tumour that were not admitted to ICU, and ICU patients without a cancer diagnosis. One in twenty patients diagnosed with a solid tumour (5.2%) were admitted to ICU with the majority receiving organ support during their ICU stay. ICU admission tended to occur soon after cancer diagnosis and was therefore likely related to the cancer diagnosis or its treatment. The rate of ICU admission was greatest for bowel malignancies (16.5% of colorectal cancer patients) and for those tumours that require peri-operative ICU support for tumour resection surgery such as head and neck cancers (12.8%), stomach cancer (11.3%) and oesophageal cancer (10.2%). When compared with the ICU population without cancer, patients with solid tumours tended to be older (median age 68 years vs. 59 years, respectively), with a higher proportion of elective hospitalisations (52.7% vs. 10.0%) and were predominantly admitted to ICU with a surgical illness (89.3% vs. 55.0%). Surgical ICU admissions have a favourable ICU and hospital mortality if they have an underlying cancer diagnosis compared with surgical ICU patients without cancer (hospital mortality 22.9% vs. 28.1%, respectively). A potential explanation for this would be a higher proportion of level 2 admissions, lower utilisation of multi-organ support and an opportunity for pre-operative optimisation within the cancer group. ICU cancer patients admitted with a medical diagnosis have poorer short-term survival than those without cancer (hospital mortality 49.1% vs. 41.7%, respectively) and this difference is even more pronounced in those that received organ support (62.5% vs. 46.2%). In patients that survive an admission to ICU the presence of cancer has the largest impact upon mortality risk in the longer-term with a risk of death over three times greater than in the population of ICU survivors without cancer. Long-term survival varies considerably by underlying tumour type with four-year survival varying from 10.0% in patients with hepatocellular carcinoma to 73.3% in patients with testicular cancer. Cancer-related factors such as tumour stage have an important role in determining mortality risk in the longer term for survivors of ICU with cancer. In patients with colorectal cancer that had survived an ICU admission the risk of death after six-months was significantly higher in patients with Dukes D stage vs. Dukes A (HR 8.66). The work presented in this thesis systematically reviews and summarises the current published outcomes of patients with solid tumours admitted to ICU, demonstrates that among the solid tumour population ICU admission is common and shows that short-term outcomes vary significantly by features associated with both the critical illness and the underlying tumour type. In patients that survive an ICU admission the presence, type and stage of cancer is important for determining on-going mortality risk. This information may be used when clinicians are discussing potential outcomes following admission to critical care with cancer patients. Future studies should focus on the administration of treatments for cancer after critical illness and whether they differ from those received by those patients without an ICU admission. Prospective studies are required to describe the pre-ICU deteriorations in physiology in cancer patients with critical illness including those considered, but not admitted, to ICU. Outcomes for this latter group are unknown and given the high burden of illness severity documented in ICUs within the UK, these studies may identify a group of patients for whom critical care would be beneficial but is not currently provided.

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Книги з теми "Neoplasie solide"

1

Allan, Alison Lawrie. Cancer stem cells in solid tumors. New York: Humana Press, 2011.

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2

Cancer stem cells in solid tumors. New York: Humana Press, 2011.

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3

Hugosson, Claes. Diagnosis of solid abdomino-pelvic tumours in children: A retrospective radiological study. Copenhagen: Munksgaard, 1999.

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4

L, Leong Stanley P., and Wong Jan H, eds. Sentinel lymph nodes in human solid cancer. Philadelphia: W.B. Saunders, 2000.

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5

1951-, Aapro M. S., ed. Innovative antimetabolites in solid tumours. Berlin: Springer-Verlag, 1994.

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6

Quintás-Cardama, Alfonso. Targeted therapy for solid tumors and hematologic malignancies. Hauppauge, N.Y: Nova Science Publishers, 2010.

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7

Diagnosis and management of malignant solid tumors in infants and children. Boston: Nijhoff Publishers, 1985.

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8

International, Symposium on Cellular Oncology (2nd 1985 Palm Springs Calif ). Occult nodal metastasis in solid carcinomata. New York: Praeger, 1987.

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9

1956-, Pummer K., ed. Biological modulation of solid tumours by interferons. Berlin: Springer-Verlag, 1994.

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10

Slabý, Ondřej. MicroRNAs in solid cancer: From biomarkers to therapeutic targets. Hauppauge, N.Y: Nova Science, 2011.

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Частини книг з теми "Neoplasie solide"

1

Campbell, Fiona, and Caroline S. Verbeke. "Solid-Pseudopapillary Neoplasia." In Pathology of the Pancreas, 227–35. London: Springer London, 2013. http://dx.doi.org/10.1007/978-1-4471-2449-8_18.

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2

Campbell, Fiona, and Caroline S. Verbeke. "Solid Pseudopapillary Neoplasia." In Pathology of the Pancreas, 295–304. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-49848-1_18.

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3

Ludwig, Wolf-Dieter, Arnold Ganser, and Georg Maschmeyer. "Hämatologische Neoplasien und solide Tumore." In Arzneiverordnungs-Report 2022, 85–151. Berlin, Heidelberg: Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-66303-5_5.

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4

Zamboni, Giulia Anna, Maria Chiara Ambrosetti, Sara Pecori, Riccardo Manfredi, and Paola Capelli. "Solid Pseudopapillary Neoplasms." In Imaging and Pathology of Pancreatic Neoplasms, 349–72. Milano: Springer Milan, 2014. http://dx.doi.org/10.1007/978-88-470-5678-7_6.

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5

van Praag, Jasper B., Robert C. Keskey, Eli D. Ehrenpreis, and John C. Alverdy. "Primary Solid Neoplasms." In The Mesenteric Organ in Health and Disease, 299–311. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-71963-0_31.

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6

Chhieng, David C., and Edward B. Stelow. "Solid-Pseudopapillary Neoplasm." In Pancreatic Cytopathology, 95–107. Boston, MA: Springer US, 2007. http://dx.doi.org/10.1007/978-0-387-68947-0_7.

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7

Paini, Marina, Giuseppe Zamboni, Riccardo Manfredi, Salvatore Paiella, and Giuseppe Malleo. "Solid-pseudopapillary, Acinar, and Other Cystic Neoplasms." In Uncommon Pancreatic Neoplasms, 23–31. Milano: Springer Milan, 2013. http://dx.doi.org/10.1007/978-88-470-2673-5_4.

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8

La Rosa, Stefano, and Amedeo Sciarra. "Solid Pseudopapillary Neoplasm (SPN)." In Pathology of the Pancreas, 209–13. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-62416-3_5556.

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9

La Rosa, Stefano, and Amedeo Sciarra. "Solid Pseudopapillary Neoplasm (SPN)." In Encyclopedia of Pathology, 1–5. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-28845-1_5556-1.

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10

Kukar, Moshim, and Steven N. Hochwald. "Surgery for Solid Pancreatic Neoplasms." In Pancreatic Masses, 219–35. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-19677-0_17.

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Тези доповідей конференцій з теми "Neoplasie solide"

1

Abreu, Thiago Martins de, Arthur Gomes Pidde, Pedro Henrique de Ávila Perillo, Silvaleide Ataides Assunção, Ianca Leandra Santos, and Débora Sara de Almeida Cardoso. "DELAY IN THE DIAGNOSIS OF INVASIVE DUCTAL CARCINOMA DUE TO AN INFECTIOUS MASTITIS: CASE REPORT." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2067.

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Introduction: Breast cancer is the most common cause among women, with invasive ductal carcinoma (ICD) being the most prevalent and having great phenotypic and genotypic heterogeneity and the ability to metastasize. In turn, mastitis is an inflammation in the breast region, infectious or noninfectious causes, most commonly affecting lactating women. Objectives: It is intended to report a case of ICD accompanied by infectious mastitis and its reverberations. Case Report: A 27-year-old woman presents with a clinical history of mastitis in her left breast that occurred about 3 months ago after weaning her son. She also explained about the use of antibiotic therapy, multiple previous drainages, and local complication with engorgement, edema, erythema, and purulent drainage in the surgical ostium of the left breast. A new drainage and material collection was carried out. Computed tomography of the chest indicated a solid heterogeneous lesion, dense, irregular contours, with areas of air trapping, liquefaction, and cleavage plane with the left pectoralis major muscle and ipsilateral axillary adenomegaly. Pathological pathology confirmed the hypothesis of neoplasia, indicating grade III ICD in comedonecrosis. Immunohistochemistry demonstrated triple-negative character and culture, positivity for Corynebacterium renale. She started neoadjuvant chemotherapy with reduced breast volume and absence of secretion today. Discussion: This is a common and problematic situation in health systems. Repeated outpatient referrals, invasive processes without resolution, aggravating the patient’s case. Moreover, it is noted that mastitis has delayed the diagnosis of the neoplasm, which, depending on the delay, may result in a worse prognosis or a more aggressive or expensive treatment. Conclusion: The diagnostic investigation of neoplasms is of great importance in case of prolonged mastitis not responsive to treatment, due to the fact that many mastitides may come from neoplastic processes that generate the lesion, which can make this injured area conducive to bacterial proliferation.

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2

Brose, A., A. G. Krombach, and D. Berthold. "Die Solid-Pseudopapilläre Neoplasie (SPN) – ein seltener Pankreastumor bei einem Jugendlichen." In 103. Deutscher Röntgenkongress der Deutschen Röntgengesellschaft e. V. Georg Thieme Verlag, 2022. http://dx.doi.org/10.1055/s-0042-1756598.

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3

Khulugurov, Vitaliy M., Nikolai Ivanov, Byoung-Chul Kim, Alexander Mayorov, Dnitri Bordzilovsky, Valentina Masycheva, Elena Danilenko, and Moon-Kwan Chung. "Solid state lasers for photodynamic therapy of malignant neoplasm." In International Symposium on Biomedical Optics, edited by Tuan Vo-Dinh, David A. Benaron, and Warren S. Grundfest. SPIE, 2002. http://dx.doi.org/10.1117/12.466650.

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4

Stella, Giulia Maria, Chandra Bortolotto, Filippo Antonacci, Roberto Dore, Manuela Coretti, Ciuffreda Antonio, Carnevale Sergio, and Morbini Patrizia. "Non-solid neoplastic nodules are associated with low PD L1 expression." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa4816.

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5

Camacho, Ana Thereza da Cunha Uchoa, Ana Paula Pontes Rodrigues, Maria Clara Sousa Peixoto, Rebeca de Sousa França, and Lívia Nazaré Soares Silva. "RECURRENT PHYLLODES TUMOR MALIGNANCY: A CASE REPORT." In XXIV Congresso Brasileiro de Mastologia. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s1070.

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Fibroepithelial tumors of the breast are part of a heterogeneous group of biphasic neoplasms, which include common fibroadenomas (FA) and phyllodes tumors (PTs). The PT is a rare fibroepithelial tumor that is histologically divided into three grades: benign, malignant, or borderline. Although only about 10% of these tumors are malignant, even benign tumors are prone to local recurrence and can become very large in size. The standard management of PT is surgical excision with negative surgical margins, due to the propensity for local recurrence. Therefore, the report about this type of tumor with multiple recurrences and malignization in the same person is important for the literature. A female patient, 30 years old, without comorbidities, with an obstetrical history of an abortion due to anembryonic egg and with a previous oncological history of four left breast segmental resections for the removal of solid nodules, confirmed anatomopathologically as borderline PT, benign PT, FA, and benign PT, respectively, in the years 2017, 2018, 2018, and 2019, was observed. No intercurrences were noted in the follow-up with a mastologist who found, in the physical examination, the presence of nodules and a palpable left breast, which caused discomfort when lying in the left decubitus position, with painless, nonsecretive, without palpable lymph nodes, and with accelerated growth. Ultrasonography revealed the presence of simple cysts in the right breast and two solid nodules BI-RADS 4 compatible with the diagnostic hypothesis of PT; therefore, surgical resection was indicated. However, with the increase in the volume of the nodules, it was not possible to obtain free margins and a simple mastectomy was chosen. On November 11, 2021, a left mastectomy was performed with partial resection of the pectoralis major muscle due to an intraoperative infiltrative lesion and immediate breast reconstruction with the placement of silicone prosthesis, without complications. In the anatomopathological examination, a malignant PT was identified with an infiltrative border pattern and the presence of neoplastic infiltration in the underlying skeletal muscle tissue. On December 23, 2021, the oncologist informed that the CT-PET performed days before denoted the absence of sites suggestive of a neoplastic process and the presence of a probable inflammatory scarring process in the left breast around the breast prosthesis. She is currently being followed up by the mastologist and the oncologist, through imagining examinations together with the clinical consultation, without the use of chemotherapies.

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6

Park, Minhee, Minhee Cho, SeongJu Yoon, and Hoguen Kim. "Abstract 560: Distinct protein expression patterns of solid pseudopapillary neoplasm of pancreas." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-560.

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7

Soni, Abhishek, Nupur Bansal, A. K. Dhull, Vivek Kaushal, Rajeev Atri, and Monica Verma. "Diagnostic dilemma of mesonephric adenocarcinoma cervix." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685283.

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Introduction: Mesonephric carcinoma is a rare type of epithelial tumor of the uterine cervix which derive from the remnants of the paired mesonephric (Wolff’s) ducts. The incidence of such neoplasms is difficult to determine due to rarity, previous misclassification of clear cell carcinomas and yolk sac tumours as mesonephric carcinomas and potential underreporting due to misclassification of mesonephric carcinoma as Mullerian tumours or mesonephric hyperplasia. The evidence regarding the clinical course, prognosis and optimal treatment is limited. Materials and Methods: Searches were performed on MEDLINE, EMBASE and Google Scholarly articles. All the relevant articles were included in the study. Only approximate 40 cases have been reported till now. Discussion: Mesonephric adenocarcinoma cervix has different morphologies like ductal, tubular, solid, retiform, sex-cord like pattern, clear cell and serous papillary structures. IHC assessment is helpful in differentiating it from Mullerian counterpart, as it is negative for CEA, CK20, p16, PAX2, ER/PR and vimentin and positive for CD10, calretinin, CK7, CAM5.2 and EMA. It has no relation with HPV infection. Unlike squamous epithelial carcinoma, it is rarely presenting with the abnormal cervical smear result, has more advanced age at presentation and its incidence does not appear to decline with age. The diagnosis has been supported by endometrial curettings, directed/cone cervical biopsies and hysterectomy specimens. The majority of patients are diagnosed at stage IB with mean DFS of 48.6 months. Recurrence rate is 23%, with a mean interval of 40 months. Hysterectomy is the primary treatment. Advanced stage disease of adenocarcinoma seemed to respond to radiotherapy, but for the MMMTs the combination of chemotherapy with radiotherapy appears to be preferable. Conclusion: Rarity of the neoplasm, varied morphology, mix presentation and very low number of cases leads to difficulty in correct diagnosis in a small biopsy specimen. IHC helpful in differentiating it from other lesions.

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8

Stella, Giulia Maria, Antonio Ciuffreda, Maria Chiara Mennitti, Patrizia Morbini, Filippo Antonacci, Chandra Bortolotto, Roberta Catania, and Roberto Dore. "Matching morphological and molecular analysis of not-solid neoplastic lung nodules. A single institution experience." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa846.

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9

Das, Sujata. "Poster Abstract." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685400.

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Haemangiomas of the ovary are very rare neoplasms with a wide age range and present with pain lower abdomen and adenexal mass. Many a times this is an incidental finding on surgery. These neoplasms should be considered in the differential diagnosis of haemorragic ovarian lesion. A 48 yr old female presented to us with pain lower abdomen and adenexal mass. Her routine investigations were normal. Her tumour markers were S. LDH 213, CEA 1.72, CA 125 was 2.3. Ultrasound findings showed a well defined echogenic mass in left ovary measuring 6 x 3.4 cm with no ascitis. Her cervical cytological findings were with in normal limits. Staging laprotomy was done and a bilobed solid ovarian mass was identified on left side. TAH with BSO was done and specimen saved for histopathology that finally showed cavernous haemangioma of ovary. Post op recovery was uneventful with subsequent relief of pain.

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Gaptulbarova, K. A., M. M. Cyganov, N. V. Litvyakov, and M. K. Ibragimova. "GENOME-WIDE ANALYSIS OF A TRIPLE NEGATIVE BREAST TUMORS." In I International Congress “The Latest Achievements of Medicine, Healthcare, and Health-Saving Technologies”. Kemerovo State University, 2023. http://dx.doi.org/10.21603/-i-ic-29.

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Today, breast cancer (BC) is not only a heterogeneous solid malignant neoplasm, but also a heterogeneous disease in terms of prognosis and sensitivity to anticancer therapy. The search for markers to predict the course of the disease and an approach to prevent recurrence and metastasis is of great importance for improving the survival of patients with triple-negative type (TN) breast cancer. Therefore, the aim of the work was to conduct a genome-wide analysis of a breast tumor with a TNBC.

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