Добірка наукової літератури з теми "Nanoparticels"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "Nanoparticels".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Статті в журналах з теми "Nanoparticels"
Yang, Chun, Feng Yan Ge, Jin Cai Li, Zai Sheng Cai, and Fang Fang Qin. "Silver Nanoparticles with Enhanced Fluorescence Effects on Fluorescein Derivative." Advanced Materials Research 602-604 (December 2012): 187–91. http://dx.doi.org/10.4028/www.scientific.net/amr.602-604.187.
Повний текст джерелаTrzaskus, K. W., A. J. B. Kemperman, and D. C. Nijmeijer. "Fouling Behavior of Silver Nanoparticels During Membrane Filtration." Procedia Engineering 44 (2012): 2096–97. http://dx.doi.org/10.1016/j.proeng.2012.09.058.
Повний текст джерелаShan, Feng, and Tong Zhang. "Shape and Size Dependent Light Absorption Enhancement of Silver Nanostructures in Organic Solar Cells." Solid State Phenomena 266 (October 2017): 90–94. http://dx.doi.org/10.4028/www.scientific.net/ssp.266.90.
Повний текст джерелаKilic, Mehmet Emin, and Sakir Erkoc. "Structural Properties of ZnO Nanoparticels and Nanorings: Molecular Dynamics Simulations." Journal of Computational and Theoretical Nanoscience 10, no. 6 (June 1, 2013): 1490–96. http://dx.doi.org/10.1166/jctn.2013.2878.
Повний текст джерелаRuan, Li Li, Da Xin Wang, You Wei Zhang, Jiong Xin Zhao, Min Wu Wang, Xiu Fang Zhang, and Nan Liang Chen. "Study on Preparation and Property of Drug Loading of AZM-PCL Nanoparticels." Applied Mechanics and Materials 121-126 (October 2011): 1764–68. http://dx.doi.org/10.4028/www.scientific.net/amm.121-126.1764.
Повний текст джерелаWang, X., Z. Yang, Y. Zhang, L. Jing, Y. Zhao, Y. Yan, and K. Sun. "MnO2Supported Pt Nanoparticels with High Electrocatalytic Activity for Oxygen Reduction Reaction." Fuel Cells 14, no. 1 (December 10, 2013): n/a. http://dx.doi.org/10.1002/fuce.201300102.
Повний текст джерелаA. A. Aljabali, Alaa, Hamid A. Bakshi, Faruck L. Hakkim, Yusuf A. Haggag, Khalid M. Al-Batanyeh, Mazhar S. Al Zoubi, Bahaa Al-Trad та ін. "Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α". Cancers 12, № 1 (1 січня 2020): 113. http://dx.doi.org/10.3390/cancers12010113.
Повний текст джерелаZamorina, S. A., P. V. Khramtsov, M. B. Rayev, V. P. Timganova, M. S. Bochkova, A. I. Nechaev, E. O. Shunkin, O. G. Khaziakhmatova, V. V. Malaschenko, and L. S. Litvinova. "Graphene Oxide Nanoparticels Interaction with Jurkat Cell Line in Cell-IQ System." Doklady Biochemistry and Biophysics 501, no. 1 (November 2021): 438–43. http://dx.doi.org/10.1134/s1607672921060089.
Повний текст джерелаZHANG Yang, 张杨, 李学红 LI Xue-hong, and 彭成晓 PENG Cheng-xiao. "Tunable Photoluminescence of ZnO Films with Different Surfaces by The Coating of Au Nanoparticels." Chinese Journal of Luminescence 33, no. 12 (2012): 1299–303. http://dx.doi.org/10.3788/fgxb20123312.1299.
Повний текст джерелаDroigk, Christine, Marco Maass, and Alfred Mertins. "Direct multi-dimensional Chebyshev polynomial based reconstruction for magnetic particle imaging." Physics in Medicine & Biology 67, no. 4 (February 16, 2022): 045014. http://dx.doi.org/10.1088/1361-6560/ac4c2e.
Повний текст джерелаДисертації з теми "Nanoparticels"
Barbero, Francesco. "Physicochemical characterization of the evolution of metal nanoparticles in biological and environmental media: from synthesis to interaction with living organisms." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/670187.
Повний текст джерелаLa creciente producción de nanopartículas (NP) conducirá inevitablemente a un aumento de la exposición humana y ambiental a estos materiales. En consecuencia, han surgido preocupaciones razonables con respecto a sus posibles riesgos de seguridad, dando lugar a la disciplina de nanotoxicología/nanoseguridad. Debido a la alta reactividad, los NP expuestos a diferentes escenarios biológicos y ambientales tienden a alcanzar un estado termodinámico más estable a través de la agregación, la interacción con las moléculas presentes en el medio ambiente, la adsorción a la materia macro-orgánica, las transformaciones químicas y la disolución. Todas estas transformaciones pueden generar una nueva identidad de los nanoobjetos o producir nuevas entidades químicas, cambiando así su comportamiento y, en consecuencia, su riesgo asociado potencial. Por lo tanto, los mismos NP pueden tener un destino totalmente diferente y, en consecuencia, un impacto totalmente diferente en los organismos vivos y el medio ambiente dependiendo del microambiente (por ejemplo, el medio de exposición) en el que se encuentran. Además, las características prístinas del nanomaterial influyen mucho en su destino biológico y medioambiental. Desde esta perspectiva, resulta fundamental comprender las características del objeto final que encontrará organismos vivos y analizar sus propiedades, a fin de correlacionar las características de NP prístinas y finales con los posibles efectos sobre los organismos vivos. En este contexto, el objetivo de esta tesis ha sido el estudio de la transformacion fisicoquímico de NP modelo expuestos a medios biológicos y ambientales. Para estos estudios, se eligieron NPs de Au y Ag, ya que son modelos de NP ampliamente utilizados y debido a sus numerosas aplicaciones. En primer lugar, el estudio se centró en la influencia de la composición de los medios de cultivo celular en el proceso de formación de protein corona, la composición final y el estado de agregación de NP y los efectos consiguientes en la absorción de células NP. También se realizó una caracterización fisicoquímica de la naturaleza de la bicapa CTAB - Au NP para estudiar el impacto de este recubrimiento de superficie NP ampliamente utilizado en la exposición de la partícula a los fluidos biológicos, en la formación de la corona de proteínas y en el diseño e interpretación de Pruebas de toxicidad NP. Finalmente, la evolución de NP en agua dulce natural se exploró mediante la realización de un estudio de la naturaleza de interacción de NP y materia orgánica natural y las características derivadas de NP.
The increasing production of engineered Nanoparticles (NPs) will inevitably lead to an increase of human and environmental exposition to these materials. Consequently reasonable concerns have arisen regarding their potential safety risks, giving rise to the nanotoxicology/nanosafety discipline. Because of the high reactivity, NPs exposed to different biological and environmental scenarios, tend to reach a more stable thermodynamic state via aggregation, interaction with the molecules present in the environment, adsorption to macro-organic matter, chemical transformations and dissolution. All these transformations can generate a new identity of the nano-objects or produce new chemical entities, thereby changing their behaviour and consequently their potential associated risk. Thus, the same NPs can have a totally different fate and consequently a totally different impact on living organisms and the environment depending on the microenvironment (e.g., the exposure medium) in which they are. Furthermore, the pristine features of nano-material highly influence their biological and environmental fate. From this perspective, it becomes fundamental to understand the characteristics of the final object that will encounter living organisms and analyze its properties, in order to correlate the pristine and final NP features with the potential effects on living organisms. In this context, the focus of this thesis has been on the physicochemical transformation of model NPs exposed to biological and environmental media. For these studies, Au and Ag NPs were chosen as they are widely used NP models and because of their numerous applications. Firstly, the study focused on the influence of the cell culture media composition on the protein corona (PC) formation process, final composition and NPs aggregation state and the consequent effects on NP cell uptake. A physicochemical characterization of the nature of the CTAB - Au NP bilayer was also carried out to study the impact of this widely used NP surface coating on the particle’s exposition to biological fluids, on the formation of the protein corona and on the design and interpretation of NP toxicity tests. Finally, the NP evolution in natural fresh water was explored by carrying out a study of the interaction nature of NPs and natural organic matter and the deriving NP features.
Lemaître, Caroline. "Contribution à l'étude théorique, numérique et expérimentale des nanoantennes patch optiques." Thesis, Clermont-Ferrand 2, 2016. http://www.theses.fr/2016CLF22742/document.
Повний текст джерелаIn the field of biosensors, efficient absorption of the electromagnetic field in a confined space is essential. The use of metallic nanoparticules comparable to metamaterials is the best way, to date, to amplify the field. In fact, by placing a dielectric film between a metal substrate and these particules, we allow the propagation of a gap-plasmon under these particules. This locates the magnetic field under these particules and the electric field on the edges of these nanoparticules. The resonances of this system are very sensitive to the environment of the gap-plasmon which allows very precise analysis. Although we can explain where these resonances come from, the efficiency to absorb of these structures remains poorly understood. The interferometric control is a response to this efficiency. In this report, I show that interferometric modeling of this system can fully explain the absorption. Indeed, the interferometric control well explains the presence of resonances at specific wavelenghts or the appearance of resonances when the angle of incidence is not normal. This study is very important to understand and master biosensors. In addition, this model can explain the amplification of the field in these structures and will allow us to provide the resonances of a system in various environments
Díaz, Ocaña Raquel. "Recombinant self-assembling nanoparticles for cancer therapy based on toxin and venom compounds." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670483.
Повний текст джерелаLa plataforma desarrollada de ingeniería de proteínas autoensamblables permite diseñar nanopartículas únicamente proteicas (NPs) capaces de atacar y actuar selectivamente sobre las células cancerosas mediante la interacción con receptores que se sobreexpresan. Las estructuras esféricas estables de las NPs desarrolladas y su tamaño adecuado, en combinación con los péptidos de direccionamiento involucrados, mejoran su especificidad. Además, la novedosa incorporación de segmentos de toxina y veneno ha mejorado los efectos terapéuticos de estas estructuras que son totalmente biocompatibles y que no tienen ningún portador externo o material agregado, cumpliendo de esta manera con el concepto emergente para medicamentos de precisión que involucra un fármaco recombinante libre de vehículo, autoensamblado, auto-dirigido y eficiente. Una versión modificada de la cadena catalítica de ricina A, con la capacidad de disminuir los efectos secundarios no deseados del síndrome de derrame vascular, pero conservando su citotoxicidad natural, se adaptó a la plataforma de proteínas. El diseño se desarrolló con el péptido T22, que se une a CXCR4, en el extremo N-terminal, y una cola de histidinas en el extremo C-terminal, en combinación con un fragmento del sitio escindible de furina para liberar la proteína intracelularmente, y una secuencia KDEL para evitar secreción del retículo endoplásmico. Las NPs de cadena de ricina A solubles purificadas dirigidas a CXCR4, con un diámetro promedio de 11 nm, alcanzaron un incremento de 100 veces en su citotoxicidad con un IC50 de 13 ± 0,5 x 10 -9 M en células HeLa. Pero también se produjeron por métodos recombinantes y se purificaron cuerpos de inclusión insolubles de 400-600 nm, con resultados citotóxicos parciales. El mecanismo de entrada dependiente del receptor de T22-mRTA-H6 se verificó y evaluó en un modelo de ratón con leucemia mieloide aguda (AML) mediante la inyección sistémica en la vena de la cola, donde se verificó un bloqueo importante de las células leucémicas sin toxicidad sistémica o histológica lateral en los órganos sanos. De manera similar, la clorotoxina (CTX) también se incorporó a la plataforma de proteínas con el fin de aprovechar su direccionamiento y efecto terapéutico en glioblastoma (GBM), ambas funciones en un solo péptido. Se diseñaron dos versiones que se unen a la proteína anexina-2 y la metaloproteinasa de matriz MMP-2; CTX-GFP-H6 y CTX-KRKRK-GFP-H6. Lss NPs solubles, de un diámetro promedio de 12 nm, se incubaron en células HeLa sobreexpresando anexina-2, y en células U87MG, sobreexpresando MMP2. Ambas versiones eran completamente fluorescentes, pero CTX-GFP-H6 presentó efectos citotóxicos leves, mientras que CTX-KRKRK-GFP-H6 mostró ser más citotóxico en las células U87MG que en las células HeLa. La afinidad selectiva de CTX se confirmó mediante la evaluación de su direccionamiento utilizando anticuerpos monoclonales y un suero policlonal contra la proteína de la superficie celular, actuando como un receptor de la CTX.
The developed self-assembling platform allows the engineering of protein-only nanoparticles (NPs) capable to target and act selectively over cancer cells by means of the interaction with overexpressed receptors. The stability of the spherical NP structures and their adequate size, in combination with the involved targeting peptides, enhance their specificity. Also, the novel incorporation of toxin and venom segments have improved the therapeutic effects of these fully biocompatible materials, without the need of any external carrier or added material, thus fulfilling the newfangled concept for precision medicines that involve self-assembled, self-targeted and efficient vehicle-free recombinant drugs. A modified version of the catalytic ricin A chain, with the ability to diminish the undesired vascular leak syndrome side effects but retaining its natural cytotoxicity, was adapted to the protein platform. The design was developed with the peptide T22 in the N-terminal, which binds CXCR4, and a his-tag in the C-terminal. This was combined with a furin cleavable site fragment in order to release the protein intracellularly, and a KDEL sequence to avoid endoplasmic reticulum secretion. Purified soluble CXCR4-targeted ricin A chain NPs with an average diameter of 11 nm, reached a 100-fold cytotoxic improvement with an IC50 of 13 ± 0.5 x 10 -9 M in HeLa cells. Also, insoluble 400-600 nm inclusion bodies were produced by recombinant methods and purified, with partial cytotoxic results. The receptor-dependent mechanism of T22-mRTA-H6 was verified and evaluated in an acute myeloid leukemia (AML) mouse model by systemic administration through a vein tail injection where an important blockage of the leukemic cells was verified without side systemic or histological toxicity in healthy organs. In a similar way, chlorotoxin (CTX) was also incorporated to the protein platform in order to take advantage of its targeting and therapeutic effect in glioblastoma (GBM), both functions in one peptide. Two versions that target protein Annexin-2 and the matrix metalloproteinase MMP-2 were engineered, namely CTX-GFP-H6 and CTX-KRKRK-GFP-H6. The soluble NPs of an average dimeter of 12 nm were incubated with HeLa cells, overexpressing annexin-2, and in U87MG cells, overexpressing MMP2. Both versions were fully fluorescent but CTX-GFP-H6 presented mild cytotoxic effects, whereas CTX-KRKRK-GFP-H6 showed to be more cytotoxic in U87MG cells than in HeLa cells. The selective affinity of CTX was confirmed by means of evaluating its targeting using a monoclonal antibody and a polyclonal serum against the cell surface protein, acting as a CTX receptor.
Rousseau, Youri. "Hybridation des technologies de jets de nanoparticules et de PVD pour la réalisation d’architectures nanocomposites fonctionnelles." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS347.
Повний текст джерелаThe nanocomposite films are coatings of nanoparticles embedded in a solid matrix of a different material. The advantage of these materials is their ability to exploit the unique properties of nano-objects while benefiting of the mechanical and chemical resistance properties of the matrix. These composites have very promising properties for many applications such as photovoltaics and photocatalysis. Several existing synthetic methods can produce nanocomposite materials by physical or chemical methods (co-sputtering, sol-gel, ...). However, none is flexible enough to consider the synthesis of a wide range of nanocomposites by the same method. This is an obstacle to the development on an industrial scale of this type of material. The first objective of the thesis is to develop an original synthesis process of nanocomposite films. This method is universal in which it presents no limit in the choice of nanoparticles and matrix. The developed method combines vacuum nanoparticle jets formed by an aerodynamic lens with a magnetron sputtering device for depositing the matrix. The nanoparticle jets can be coupled with any source of nanoparticles. Nanoparticles may be synthesized in situ in the gas phase or beforehand solution synthesis. A wide variety of nanoparticles can be used. Magnetron sputtering also enables to have a very wide range of materials for the matrix (metal, ceramic, polymer). During this thesis, two types of nanoparticles sources were used. The first one is a laser pyrolysis reactor and the second is an aerosol generator. The laser pyrolysis reactor enables in-situ gas phase synthesis of the nanoparticles while the aerosol generator use a suspension of previously synthesized nanoparticles. To test the robustness of the co-deposition process, two types of nanocomposite materials have been developed. The first material is composed of 35 nm spherical gold nanoparticles, chemically synthesized, in a silica matrix. The goal here is to benefit from the unique optical properties of gold nanoparticles in a film mechanically and chemically resistant. The characterizations carried out on these materials have optimized the gold nanoparticle concentration in the films to keep the mechanical and chemical properties compatible with applications while maintaining satisfactory optical properties. The second type of materials studied is composed of semiconductor nanoparticles in situ synthesized by laser pyrolysis and a metal matrix. The synthesis of this material demonstrates the flexibility of the co-deposition method to synthesize a wide variety of nanocomposite films. Finally, the design of an industrial pilot was undertaken. The final goal is to have a pilot-scale setup that meets industry requirements in the context of a technology transfer
Luo, Zhongrui. "In vivo interactions between food availability and nanoparticles in Caenorhabditis elegans." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/671182.
Повний текст джерелаDurante las últimas décadas, las nanopartículas (NPs) se han utilizado ampliamente en distintos campos, especialmente en aplicaciones médicas como fármacos, agentes de formación de imágenes y como liberadores de fármacos. Sin embargo, también han planteado dudas respecto a las posibles reacciones adversas sobre la salud humana. Así, se han realizado grandes esfuerzos de investigación en el campo de las ciencias biológicas para elucidar los mecanismos de toxicidad de distintas NPs. En este trabajo de Tesis, hemos dedicado esfuerzos a aplicar el (Caenorhabditis elegans) C. elegans como un organismo modelo robusto y simple para las evaluaciones de toxicidad de NPs. El objetivo general de esta tesis ha sido estudiar la interacción de la comida de estos gusanos con las NPs. En particular, el estudio de las interacciones nano-bio entre nanopartículas de óxido de hierro superparamagnéticas (SPIONs) o AuNPs de 10 nm en C. elegans alimentados o no; así demostrar que este pequeño animal puede utilizarse para estudiar efectos alimentarios. En primer lugar, estudiamos los efectos de la disponibilidad de alimento sobre las toxicidades inducidas por la exposición de SPIONs tras 24 h - exposición aguda - o 72 h - exposición prolongada. Descubrimos que la comida brinda cierta protección a los C. elegans, la cual se determinó midiendo la supervivencia y la reproducción. Los gusanos en la exposición aguda tuvieron una mayor eficiencia de absorción de SPIONs facilitada por la comida en comparación con la condición sin alimento. La utilización de la microespectroscopía infrarroja de Sincrotrón (SR-μFTIR) nos permitió demostrar que la exposición prolongada (24 h versus 4 h) y altas concentraciones de SPIONs (500 µg/mL versus 100 µg/mL) inducen un estrés oxidativo más severo debido a el aumento de la oxidación de lípidos. En segundo lugar, investigamos las consecuencias de la ingesta de comida sobre los gusanos después de 24 h de exposición a AuNP de 10 nm. Se identificó el papel protector de los alimentos en la reducción de efectos tóxicos. Usando SR-μFTIR, encontramos que las AuNPs de pequeño tamaño (10 nm frente a 150 nm) o la exposición prolongada (24 h frente a 4 h) causaron un mayor nivel de oxidación de lípidos que se relacionó con las respuestas contra el estrés oxidativo. Por otro lado, evaluamos preliminarmente la posibilidad de realizar la terapia fototérmica en gusanos que contenian AuNP de 150 nm. Encontramos daños por fotoablación en los puntos de irradiación láser sobre los gusanos, sugiriendo que se podría usar este gusano para evaluar NPs, pero para ello es necesario optimizar la configuración experimental. En la parte final, presentamos algunas colaboraciones donde realizamos experimentos con diferentes nanomateriales como luteína y metal-organic frameworks (MOFs), evaluados empleando C. elegans. Estudiamos las propiedades antioxidantes de la luteína en C. elegans modificados para ser modelos de enfermedades asociadas con el síndrome de Leigh y demostramos la posibilidad de aplicar microscopia de infrarrojo (SR-μFTIR) en estos estudios. Por otro lado, realizamos la evaluación preliminar de toxicidad de MOF, MIL-127 y CS-MIL-127 recubierto de quitosano (CS). Además, investigamos los efectos del recubrimiento de CS en la absorción y excreción por los C. elegans. En resumen, hemos encontrado que la disponibilidad de comida puede disminuir los efectos adversos, parcialmente asociados con el estrés oxidativo, inducidos por SPIONs o AuNPs en C. elegans. Nuestros resultados también sugieren que los C. elegans tienen un gran potencial como modelo de administración oral ya que pueden emplearse para probar diferentes materiales. Además, en combinación con otras técnicas avanzadas, nos pueden ayudar a comprender de forma más general los mecanismos de toxicidad y ampliar el rango de aplicación de las técnicas de ciencia de materiales para la investigación biológica.
During the last decades, nanoparticles (NPs) have been widely used in various fields, especially in medical applications such as drugs, imaging agents, and drug-delivery carriers. However, they also raised public concerns regarding the potential adverse influences on human health. Collective efforts from worldwide researchers in materials and biological science have been invested in investigating the toxicity mechanisms of different NPs. In this thesis, we dedicated major efforts to apply (Caenorhabditis elegans) C. elegans as a robust and simple model organism for toxicity assessments of assorted NPs. The general objective of this thesis was to study effects of food availability on nano-bio interactions between superparamagnetic iron oxide nanoparticles (SPIONs) or 10 nm AuNPs and C. elegans, and prove that this small animal can be used to study alimentary effects. Firstly, we studied the effects of food availability on toxicities induced by exposure to SPIONs after 24 h (acute exposure) or 72 h (prolonged exposure). We found that food provided some protection to C. elegans determined by measuring multiple toxicity endpoints such as survival and reproduction. Worms in the acute exposure condition had a higher uptake efficiency of SPIONS facilitated by food compared with the condition without the addition of food. The utilization of synchrotron Fourier transform infrared microspectroscopy (SR-μFTIR), allowed us to demonstrate that long-exposure (24 h versus 4 h) and high concentrations of SPIONs (500 µg/mL versus 100 µg/mL) induce more severe oxidative stress determined by increased levels of lipid oxidation. Secondly, we investigated food’s influences on worms after 24 h exposure to 10 nm AuNPs. The protective role of food was identified in reducing toxic effects, such as survival and reproduction. Using SR-μFTIR, we found that small-sized AuNPs (10 nm versus 150 nm) or long-exposure (24 h versus 4 h) caused an increased level of lipid oxidation which was related to responses against oxidative stress. On the other hand, we preliminarily evaluated the possibility of performing the photothermal therapy in worms containing 150 nm AuNPs. We found photoablated damages on the laser irradiation spots of worms, suggesting that multiple experimental settings needed to be optimized. At the end of the thesis, also we presented some collaborations where we performed some experiments with different nanomaterials such as lutein and (metal-organic frameworks) MOFs and evaluated them on C. elegans. We studied antioxidative properties of lutein in C. elegans disease models associated with Leigh Syndrome and demonstrated the possibility to apply synchrotron Fourier transform infrared microspectroscopy (SR-μFTIR) on this topic. On the other hand, we performed the preliminary toxicity assessment of MOFs, MIL-127 and chitosan (CS) coated MIL-127 (CS-MIL-127). Additionally, we investigated about effects of the chitosan (CS) coating on C. elegans’ uptake and excretion efficiencies of MIL-127 and CS-MIL-127. We reported the potential of applying C. elegans as an oral administration model of studying metal-organic frameworks’ (MOFs’) in vivo toxicities. In summary, food availability could decrease adverse effects, partially associated with oxidative stress, induce by SPIONs or AuNPs on C. elegans. It also suggested that C. elegans has a great potential of being employed as an oral administration model of testing various materials. Furthermore, combined with other advanced techniques, we could have a more general understanding of the toxicity mechanism and broaden the application range of material science techniques for biological research.
Chiewpattanakul, Paramaporn. "Isolation and structure elucidation of biosurfactant from microorganism and its application model in drug delivery system." Thesis, Vandoeuvre-les-Nancy, INPL, 2010. http://www.theses.fr/2010INPL004N/document.
Повний текст джерелаBiosurfactant producing microorganisms were isolated from oil contaminated soils collected from Songkhla and Chiangmai province, Thailand and Shianghai, China. Their culture broths were screened for obtaining biosurfactants with the highest surface activity and emulsification ability. Among 102 isolates, 6 microorganisms produced biosurfactants. The culture supernatant of SK80 strain exhibited the highest surface activity. SK80 was identified by macroscopic morphology, microscopic morphology and showed that it is a black mold. The 28S rRNA sequence homology analysis suggested that SK80 belongs to Exophiala dermatitidis. The composition of culture medium such as carbon source, nitrogen source, and culture condition of this microorganism was optimized to obtain high amounts of biosurfactant. 1H NMR, 13C NMR, COSY and Mass Spectrometer (APCI MS) results indicated that this biosurfactant was monoolein (oleoyl glycerol), a kind of monoacylglycerol. Monomyristin was chosen as a monoacylglycerol model to be synthesized and used as nanoparticle encapsulated drug. Two preparation methods, emulsion/solvent evaporation and nanoprecipitation, were used to encapsulate monomyristin in dextran-covered nanoparticles with poly(lactic acid) of hydrophobized dextran as the core material. Encapsulation conditions were optimized with regard to the yield encapsulation and the colloidal stability
Fernandez, Maxence. "Auto-assemblage de nanoparticules métalliques et semi-conductrices dirigé par reconnaissance entre protéines artificielles." Thesis, Rennes 1, 2019. http://www.theses.fr/2019REN1S129.
Повний текст джерелаNanoparticles self-assembly driven by biomolecules is a promising approach for developing nanostructured materials with new optical properties. The purpose of this work is the self-assembly of metal and semiconductor nanoparticles directed by artificial proteins called α-Repeat. For this purpose, semiconductor nanocrystals (CdSe/ZnS or CdSe/CdS) and spherical or anisotropic gold nanoparticles have been prepared. These nanoparticles have been functionalized with PEGylated peptide ligands providing them adequate colloidal stability while maintaining their optical properties. A functionalization strategy based on polycysteine and poly-histidine tags has allowed the proteins to be grafted onto the surface of inorganic nanoparticles. Nanoparticles functionalized with artificial proteins were then used for the self-assembly of semiconductor nanoparticles and hybrid self-assembly between semiconductor nanoparticles and metal nanoparticles. The structure study of self-assembled nanostructures has shown, in some cases, a very well defined sub-10 nm interparticle distance. Finally, the study of optical properties revealed very strong exciton-plasmon interactions induced by self-assembly. This self-assembling process strongly affected the emission properties of the semiconductor nanoparticles in hybrid ensembles
Tang, Lu. "Nanoparticules mimes des propriétés biologiques des GAGs : vers un inhibiteur sélectif de CXCL12." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS072.
Повний текст джерелаHéparan Sulfate (HS) is a linear polysaccharide that modulates the biological activities of numerous proteins. In order to elucidate the interaction between HS and proteins, the synthesis of HS is an invaluable tool, but the synthesis is sometimes difficult. Our group has demonstrated that the combinatorial mixtures obtained by self-assembly of different combinations of disaccharide derivatives (lactose and persulfated lactose) on gold plan surfaces could recognize specifically some HS binding proteins, such as the isoforms of the chemokine CXCL12 or IFNγ. Because of the toxicity of gold nanoparticles, we have also adapted this method to lipid nanoparticles. Using the conditions that have already improved during the synthesis of lactose and persulfated lactose derivatives, we have synthesized two other disaccharide derivatives, which were closer to the real structure of HS. These new derivatives were used to prepare the gold and lipid nanoparticles at the aim of comparing the properties with lactose and persulfated lactose. The tests of affinities with different proteins are in progress
Buchy, Eric. "Conception de bioconjugués squalénisés dotés de propriétés d'auto-assemblage : vers une méthode générale de vectorisation nanoparticulaire." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS267.
Повний текст джерелаSqualenoyl conjugates of semaxanib and sunitinib, two potent antiangiogenic (pyrrolyl)methylidenyl-substituted oxindole multitarget tyrosine kinase inhibitors, were synthesized with a hemiaminal-based pH-sensitive linker. The prodrugs were prepared according to a three-step sequence involving (i) N-alkylation with chloromethoxy-triisopropylsilane; (ii) desilylation; and (iii) acylation with trisnorsqualenic acid. These squalenoyl prodrugs were found to selfassemble into nanoassemblies in aqueous media without the need for any surfactant. The nanosized aggregates were characterized by dynamic light scattering and transmission electron microscopy, and appeared to be stable in water for several days, as determined by particle-size measurement. In vitro biological studies showed that squalenoyl sunitinib nanoassemblies are notably cytotoxic against the human umbilicalvein endothelial cell line (HUVEC), which is involved in the tumor vessel formation
Bordat, Alexandre. "Stratégies alternatives pour la délivrance d'anticancéreux par encapsulation physique dans des nanoparticules polymère thermosensibles ou par couplage chimique en prodrogues polymères." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS595.
Повний текст джерелаThis thesis focuses on innovative drug delivery systems of anticancer drugs to tackle the current limitations of formulations based on nanoparticles. These allow encapsulation of anticancer drugs to prolong their circulation time in the blood stream and to decrease side effects. Yet, nanoparticle formulations available in the clinic do not allow a precise control on the drug release nor targeting of the tumor.To overcome these hurdles, we have synthesized a thermoresponsive copolymer exhibiting an upper critical solution temperature (UCST) to formulate nanoparticles physically encapsulating doxorubicin. These allow controlled release of the anticancer drug by mild hyperthermia at 43 °C. We have studied our system from a physico-chemical point of view and evaluated its cytotoxicity in vitro on ovarian cancer cells.We have also tried a chemical coupling approach between the polymer and the anticancer drug, paclitaxel, to allow innocuous subcutaneous administration. In did, this route of administration is seldom used for anticancer drugs as some of them induce local toxicity at the site of injection in the form of skin irritation / necrosis. We assessed if a hydrophilic polymer prodrug approach allows innocuous subcutaneous administration of an irritant drug; and if a UCST polymer prodrug approach enables formation of stable nanoparticles at room temperature for subcutaneous administration. Once in the subcutaneous tissue at 34 °C, they would solubilize and become hydrophilic thus could freely diffuse to reach the blood circulation. We have managed to evaluate the hydrophilic polymer prodrug approach in vivo on nude mice and we are the first to describe the synthesis of UCST polymer prodrug
Книги з теми "Nanoparticels"
Guet, C., P. Hobza, F. Speigelman, and F. David, eds. Atomic clusters and nanoparticles. Agregats atomiques et nanoparticules. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/3-540-45621-x.
Повний текст джерелаSchmid, Günter, ed. Nanoparticles. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527631544.
Повний текст джерелаSchmid, Gnter, ed. Nanoparticles. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2003. http://dx.doi.org/10.1002/3527602399.
Повний текст джерелаRotello, Vincent, ed. Nanoparticles. Boston, MA: Springer US, 2004. http://dx.doi.org/10.1007/978-1-4419-9042-6.
Повний текст джерелаde Mello Donegá, Celso, ed. Nanoparticles. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-44823-6.
Повний текст джерелаJelinek, Raz. Nanoparticles. Berlin: Walter de Gruyter GmbH & Co., KG, 2015.
Знайти повний текст джерела1967-, Feldheim Daniel L., and Foss Colby A, eds. Metal nanoparticles: Synthesis, characterization, and applications. New York: Marcel Dekker, 2002.
Знайти повний текст джерелаJana, Nikhil Ranjan. Colloidal Nanoparticles. Boca Raton : CRC Press, Taylor & Francis Group, 2018.: CRC Press, 2019. http://dx.doi.org/10.1201/9780429165603.
Повний текст джерелаJoshy, K. S., Thomas Sabu, and Vijay Kumar Thakur, eds. Magnetic Nanoparticles. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-1260-2.
Повний текст джерелаPatra, Jayanta Kumar, Leonardo F. Fraceto, Gitishree Das, and Estefânia Vangelie Ramos Campos, eds. Green Nanoparticles. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39246-8.
Повний текст джерелаЧастини книг з теми "Nanoparticels"
de Mello Donegá, Celso. "The Nanoscience Paradigm: “Size Matters!”." In Nanoparticles, 1–12. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-44823-6_1.
Повний текст джерелаHassinen, Antti, José C. Martins, and Zeger Hens. "Solution NMR Toolbox for Colloidal Nanoparticles." In Nanoparticles, 273–93. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-44823-6_10.
Повний текст джерелаKoole, Rolf, Esther Groeneveld, Daniel Vanmaekelbergh, Andries Meijerink, and Celso de Mello Donegá. "Size Effects on Semiconductor Nanoparticles." In Nanoparticles, 13–51. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-44823-6_2.
Повний текст джерелаZijlstra, Peter, Michel Orrit, and A. Femius Koenderink. "Metal Nanoparticles for Microscopy and Spectroscopy." In Nanoparticles, 53–98. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-44823-6_3.
Повний текст джерелаde Jongh, Petra E., and Tamara M. Eggenhuisen. "Nanoporous Materials and Confined Liquids." In Nanoparticles, 99–120. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-44823-6_4.
Повний текст джерелаEggenhuisen, Tamara M., and Petra E. de Jongh. "Supported Nanoparticles." In Nanoparticles, 121–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-44823-6_5.
Повний текст джерелаGroeneveld, Esther, and Celso de Mello Donegá. "The Challenge of Colloidal Nanoparticle Synthesis." In Nanoparticles, 145–89. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-44823-6_6.
Повний текст джерелаvan Huis, Marijn A., and Heiner Friedrich. "Electron Microscopy Techniques." In Nanoparticles, 191–221. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-44823-6_7.
Повний текст джерелаLiljeroth, Peter, Bruno Grandidier, Christophe Delerue, and Daniël Vanmaekelbergh. "Scanning Probe Microscopy and Spectroscopy." In Nanoparticles, 223–55. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-44823-6_8.
Повний текст джерелаBaranov, Pavel G., Nikolai G. Romanov, Celso de Mello Donegá, Sergei B. Orlinskii, and Jan Schmidt. "Electron Paramagnetic Resonance Based Spectroscopic Techniques." In Nanoparticles, 257–72. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-44823-6_9.
Повний текст джерелаТези доповідей конференцій з теми "Nanoparticels"
Wu, Xuan, Ranganathan Kumar, and Parveen Sachdeva. "Calculation of Thermal Conductivity in Nanofluids From Atomic-Scale Simulations." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-80849.
Повний текст джерелаZhu, Youyi, Peng Yu, and Jian Fan. "Study on Nanoparticle Stabilized Emulsions for Chemical Flooding Enhanced Oil Recovery." In International Petroleum Technology Conference. IPTC, 2021. http://dx.doi.org/10.2523/iptc-21456-ms.
Повний текст джерелаLi, Lirong, and Yong Tae Kang. "Three-Dimensional Simulation of Bubble Behavior and Mass Transfer for CO2 Absorption in Nanoabsorbents." In ASME 2019 6th International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/mnhmt2019-3944.
Повний текст джерелаYu, Qun, Chao Zhu, Robert Pfeffer, and Rajesh N. Dave. "Experimental Study on Fluidization Characteristics of Nanoparticles." In ASME 2004 Heat Transfer/Fluids Engineering Summer Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/ht-fed2004-56269.
Повний текст джерелаYuksel, Anil, Michael Cullinan, and Jayathi Murthy. "Thermal Energy Transport Below the Diffraction Limit in Close-Packed Metal Nanoparticles." In ASME 2017 Heat Transfer Summer Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/ht2017-4968.
Повний текст джерелаMa, Qianli, and Haisheng Fang. "Viscosity Prediction of Water-Based Silver Nanofluid Using Equilibrium Molecular Dynamics." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-65831.
Повний текст джерелаFeng, Zhi-Gang, Yusheng Feng, and Maria Andersson. "Shape Effects on the Drag Force and Motion of Nano and Micro Particles in Low Reynolds Number Flows." In ASME 2012 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/imece2012-89469.
Повний текст джерелаJambhulkar, Sayli, and Kenan Song. "1D and 2D Nanoparticle Assembly Compliant With Tuned 3D-Printed Topology." In ASME 2022 17th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/msec2022-85050.
Повний текст джерелаPandey, Anurag Pandey, Vishnu Roy, Himanshu Kesarwani, Govind Mittal, Shivanjali Sharma, and Amit Saxena. "Effect of Silicon Carbide on the Surface Tension and Adsorption of SDS on the Sandstone Formation." In Offshore Technology Conference Asia. OTC, 2022. http://dx.doi.org/10.4043/31439-ms.
Повний текст джерелаTafazzoli, Afshin, and Metin Sitti. "Dynamic Behavior and Simulation of Nanoparticle Sliding During Nanoprobe-Based Positioning." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-62470.
Повний текст джерелаЗвіти організацій з теми "Nanoparticels"
Venedicto, Melissa, and Cheng-Yu Lai. Facilitated Release of Doxorubicin from Biodegradable Mesoporous Silica Nanoparticles. Florida International University, October 2021. http://dx.doi.org/10.25148/mmeurs.009774.
Повний текст джерелаVeloso, Rita Carvalho, Catarina Dias, Andrea Resende Souza, Joana Maia, Nuno M. M. Ramos, and João Ventura. Improving the optical properties of finishing coatings for façade systems. Department of the Built Environment, 2023. http://dx.doi.org/10.54337/aau541592743.
Повний текст джерелаJohnson, David, Robert Boyd, Anthony Bednar, Cynthia Banks, Charles Weiss, Jessica Coleman, Burton Suedel, and Jeffery Steevens. Terrestrial fate and effects of nanometer-sized silver. Engineer Research and Development Center (U.S.), March 2022. http://dx.doi.org/10.21079/11681/43800.
Повний текст джерелаSagaiyaraj, Bernard. Increasing Energy Efficiency of Central Cooling Systems with Engineered Nanofluids. Department of the Built Environment, 2023. http://dx.doi.org/10.54337/aau538344493.
Повний текст джерелаChefetz, Benny, Baoshan Xing, and Yona Chen. Interactions of engineered nanoparticles with dissolved organic matter (DOM) and organic contaminants in water. United States Department of Agriculture, January 2013. http://dx.doi.org/10.32747/2013.7699863.bard.
Повний текст джерелаWiesmann, Harold, and Michael Furey. Manufacture of YBCO Superconducting Flexible Tapes from Nanoparticel Films Derived from Sedimentation and by Flame Depostion of Nanoparticles from Solution. Office of Scientific and Technical Information (OSTI), February 2008. http://dx.doi.org/10.2172/974563.
Повний текст джерелаHuang, Dan, Mirian Velay-Lizancos, and Jan Olek. Improving Scaling Resistance of Pavement Concrete Using Titanium Dioxide (TiO2 ) and Nanosilica. Purdue University, 2022. http://dx.doi.org/10.5703/1288284317583.
Повний текст джерелаChumanov, George. Asymmetric Hybrid Nanoparticles. Office of Scientific and Technical Information (OSTI), November 2015. http://dx.doi.org/10.2172/1225813.
Повний текст джерелаHavrilla, George Joseph. Nanoparticle standards. Office of Scientific and Technical Information (OSTI), December 2016. http://dx.doi.org/10.2172/1335590.
Повний текст джерелаBalch, William M., James Vaughn, and Joaquim I. Goes. Nanoparticles and Ocean Optics. Fort Belvoir, VA: Defense Technical Information Center, September 2008. http://dx.doi.org/10.21236/ada533234.
Повний текст джерела