Готові списки джерел за темами / Muscle ageing

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Добірка наукової літератури з теми "Muscle ageing"

Автор: Grafiati

Опубліковано: 13 квітня 2024

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Статті в журналах з теми "Muscle ageing"

Tkacz, Katarzyna, Monika Modzelewska-Kapituła, Adam Więk та Zenon Nogalski. "The Applicability of Total Color Difference ΔE for Determining the Blooming Time in Longissimus Lumborum and Semimembranosus Muscles from Holstein-Friesian Bulls at Different Ageing Times". Applied Sciences 10, № 22 (20 листопада 2020): 8215. http://dx.doi.org/10.3390/app10228215.

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This study was conducted to determine the optimal blooming time in beef muscles based on ΔE, and to analyze the effects of muscle type and ageing time on beef color and blooming. Beef color was determined on freshly cut longissimus lumborum (LL, n = 8) and semimembranosus (SM, n = 8) muscles on days 1, 9, and 14 of ageing during 60 min blooming at 5 min intervals. It was found that ΔE0, representing the difference in color between freshly cut muscles and subsequently analyzed samples, supported the determination of the optimal blooming time, which varied across ageing times (15, 20, 25 min for the LL muscle, and 10, 15, 20 min for the SM muscle on days 1, 9, and 14 of ageing, respectively). Beef color was affected by both muscle type and ageing. The values of color parameters increased between days 1 and 9 of ageing. The results may have practical applications because beef should be presented to consumers and restaurant owners approximately 25 min after cutting, when its color has fully developed.

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Charles, James P., and Karl T. Bates. "The Functional and Anatomical Impacts of Healthy Muscle Ageing." Biology 12, no. 10 (October 23, 2023): 1357. http://dx.doi.org/10.3390/biology12101357.

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Even “healthy” muscle ageing is often associated with substantial changes in muscle form and function and can lead to increased injury risks and significant negative impacts on quality of life. However, the impacts of healthy muscle ageing on the fibre architecture and microstructure of different muscles and muscle groups throughout the lower limb, and how these are related to their functional capabilities, are not fully understood. Here, a previously established framework of magnetic resonance and diffusion tensor imaging was used to measure the muscle volumes, intramuscular fat, fibre lengths and physiological cross-sectional areas of 12 lower limb muscles in a cohort of healthily aged individuals, which were compared to the same data from a young population. Maximum muscle forces were also measured from an isokinetic dynamometer. The more substantial interpopulation differences in architecture and functional performance were located within the knee extensor muscles, while the aged muscles were also more heterogeneous in muscle fibre type and atrophy. The relationships between architecture and muscle strength were also more significant in the knee extensors compared to other functional groups. These data highlight the importance of the knee extensors as a potential focus for interventions to negate the impacts of muscle ageing.

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Lexell, Jan. "Ageing and Human Muscle: Observations From Sweden." Canadian Journal of Applied Physiology 18, no. 1 (March 1, 1993): 2–18. http://dx.doi.org/10.1139/h93-002.

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The purposes of this review are to summarize studies of cross-sections of autopsied whole muscles from previously physically healthy males and to focus on the cause of the ageing atrophy. The ageing atrophy begins around 25 years of age and thereafter accelerates. This is caused mainly by a loss of muscle fibres, and to a lesser extent by a reduction in fibre size, mostly of the proportion of the fibre area in the muscle cross-section occupied by type 2 (fast-twitch) fibres. In muscle from old subjects, there is a significant increase in the number of enclosed fibres, indicating an increased incidence of fibre type grouping, a loss of motor neurons in the spinal cord, and a reduction in the number of functioning motor units. These findings strongly suggest a combination of a progressive denervation process and an altered physical activity level as the two major mechanisms underlying the effects of normal ageing on human muscle. These changes have obvious implications for old individuals and their participation in physical activity and in sports, which must be accommodated in rehabilitation regimes or in training programmes. Key words: ageing, microscopy, muscles, physiological adaptation

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Roman, Michael A., Harry B. Rossiter, and Richard Casaburi. "Exercise, ageing and the lung." European Respiratory Journal 48, no. 5 (October 6, 2016): 1471–86. http://dx.doi.org/10.1183/13993003.00347-2016.

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This review provides a pulmonary-focused description of the age-associated changes in the integrative physiology of exercise, including how declining lung function plays a role in promoting multimorbidity in the elderly through limitation of physical function. We outline the ageing of physiological systems supporting endurance activity: 1) coupling of muscle metabolism to mechanical power output; 2) gas transport between muscle capillary and mitochondria; 3) matching of muscle blood flow to its requirement; 4) oxygen and carbon dioxide carrying capacity of the blood; 5) cardiac output; 6) pulmonary vascular function; 7) pulmonary oxygen transport; 8) control of ventilation; and 9) pulmonary mechanics and respiratory muscle function. Deterioration in function occurs in many of these systems in healthy ageing. Between the ages of 25 and 80 years pulmonary function and aerobic capacity each decline by ∼40%. While the predominant factor limiting exercise in the elderly likely resides within the function of the muscles of ambulation, muscle function is (at least partially) rescued by exercise training. The age-associated decline in pulmonary function, however, is not recovered by training. Thus, loss in pulmonary function may lead to ventilatory limitation in exercise in the active elderly, limiting the ability to accrue the health benefits of physical activity into senescence.

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Cvetko, Erika, Jiří Janáček, Lucie Kubínová, and Ida Eržen. "THE CAPILLARY PATTERN IN HUMAN MASSETER MUSCLE DURING AGEING." Image Analysis & Stereology 32, no. 3 (October 12, 2013): 135. http://dx.doi.org/10.5566/ias.v32.p135-144.

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The effect of ageing on the capillary network in skeletal muscles has produced conflicting results in both, human and animals studies. Some of the inconsistencies are due to non-comparable and biased methods that were applied on thin transversal sections, especially in muscles with complicated morphological structures, such as in human masseter muscle. We present a new immunohistochemical method for staining capillaries and muscle fibres in 100 µm thick sections as well as novel approach to 3D visualization of capillaries and muscle fibres. Applying confocal microscopy and virtual 3D stereological grids, or tracing capillaries in virtual reality, length of capillaries within a muscle volume or length of capillaries adjacent to muscle fibre per fibre length, fibre surface or fibre volume were evaluated in masseter muscle of young and old subjects by an unbiased approach. Our findings show that anatomic capillarity is well maintained in masseter muscle in old subjects; however, vascular remodelling occurs with age, which could be a response to changed muscle function and age-related muscle fibre type transformations.

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Strzyz, Paulina. "Autophagy rescues muscle ageing." Nature Reviews Molecular Cell Biology 17, no. 2 (January 21, 2016): 67. http://dx.doi.org/10.1038/nrm.2016.3.

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Florek, Mariusz, Andrzej Junkuszew, Wiktor Bojar, Piotr Skałecki, Monika Greguła-Kania, Anna Litwińczuk, and Tomasz M. Gruszecki. "21. Effect of Vacuum Ageing on Instrumental and Sensory Textural Properties of Meat from Uhruska Lambs." Annals of Animal Science 16, no. 2 (April 1, 2016): 601–9. http://dx.doi.org/10.1515/aoas-2015-0084.

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Abstract The objective of the present research was to assess the instrumental and sensory textural attributes of lamb meat depending on the cold storage ageing under vacuum. The research material included two skeletal muscles, i.e. semimembranosus (SM) and rectus femoris (RF) from carcasses of Uhruska lambs. The age of animals ranged from 120 to 135 days. The ageing and muscle influenced significantly shear force and shear energy. However, significantly lower shear force and higher score of tenderness were observed on 7 vs. 2 days of ageing only for SM. The evaluated factors (ageing and muscle) affected slightly and not significantly the parameters of texture profile analysis. The muscle samples after the 7-day ageing showed higher hardness and chewiness. Significant correlation of sensory tenderness with instrumental shear and energy force and springiness was confirmed. The obtained results indicated that vacuum-packed lamb meat during cold storage for 7 days following slaughter develops the sensory attributes, especially tenderness.

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Koopman, René. "Dietary protein and exercise training in ageing." Proceedings of the Nutrition Society 70, no. 1 (November 22, 2010): 104–13. http://dx.doi.org/10.1017/s0029665110003927.

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Ageing is accompanied by a progressive loss of skeletal muscle mass and strength, leading to the loss of functional capacity and an increased risk for developing chronic metabolic diseases such as diabetes. The age-related loss of skeletal muscle mass results from a chronic disruption in the balance between muscle protein synthesis and degradation. As basal muscle protein synthesis rates are likely not different between healthy young and elderly human subjects, it was proposed that muscles from older adults lack the ability to regulate the protein synthetic response to anabolic stimuli, such as food intake and physical activity. Indeed, the dose–response relationship between myofibrillar protein synthesis and the availability of essential amino acids and/or resistance exercise intensity is shifted down and to the right in elderly human subjects. This so-called ‘anabolic resistance’ represents a key factor responsible for the age-related decline in skeletal muscle mass. Interestingly, long-term resistance exercise training is effective as a therapeutic intervention to augment skeletal muscle mass, and improves functional performance in the elderly. The consumption of different types of proteins, i.e. protein hydrolysates, can have different stimulatory effects on muscle protein synthesis in the elderly, which may be due to their higher rate of digestion and absorption. Current research aims to elucidate the interactions between nutrition, exercise and the skeletal muscle adaptive response that will define more effective strategies to maximise the therapeutic benefits of lifestyle interventions in the elderly.

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Vaskoska, Rozita, Minh Ha, Zahra Batool Naqvi, Jason David White, and Robyn Dorothy Warner. "Muscle, Ageing and Temperature Influence the Changes in Texture, Cooking Loss and Shrinkage of Cooked Beef." Foods 9, no. 9 (September 14, 2020): 1289. http://dx.doi.org/10.3390/foods9091289.

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This study aimed to quantify the effect of muscle, ageing and cooking temperature on the texture, cooking loss and shrinkage of cooked beef. Cuboids from unaged (1 day post mortem) and aged (14 days post mortem) semitendinosus, biceps femoris and psoas major muscles, from both sides of five beef carcasses, were cooked at four different cooking temperatures (50, 60, 70 and 80 °C) for 30 min. and their Warner–Bratzler shear force (WBSF), cooking loss and shrinkage (longitudinal and transverse) were quantified. The WBSF was reduced by ageing in the muscles at the specific cooking temperatures: psoas major (cooked at 50, 60 and 80 °C), semitendinosus (70 and 80 °C) and biceps femoris (80 °C). The cooking loss was 3% greater in aged compared to unaged muscles. The longitudinal shrinkage was greatest in psoas major at 80 °C amongst the muscle types and it was reduced by ageing in psoas major (70 and 80 °C) and biceps femoris (80 °C). The transverse shrinkage was reduced by ageing only in biceps femoris, across all temperatures; and the diameter of homogenized fibre fragments from semitendinosus and biceps femoris was reduced more by cooking at 50 °C in unaged compared to aged condition. WBSF was related to transverse shrinkage, and cooking loss was related to longitudinal shrinkage. The effect of muscle type on the physical changes occurring during cooking of beef is dependent on ageing and cooking temperature.

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BRUCE, H. L., and R. O. BALL. "EFFECTS OF POSTMORTEM GLYCOLYSIS ON THE QUALITY OF HOT-DEBONED BOVINE MUSCLE." Canadian Journal of Animal Science 70, no. 2 (June 1, 1990): 431–39. http://dx.doi.org/10.4141/cjas90-055.

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Meat tenderness may be improved by accelerating muscle metabolism or by damaging muscle structure and increasing the solubility of muscle proteins. Pre- and postrigor protein and collagen solubilities were measured in semitendinosus muscles, removed pre-rigor from 24 Charolais crossbred steer carcasses, that were either unstimulated or electrically stimulated (115 V, 0.25 amp, 60 Hz) within 1 h postexsanguination to accelerate muscle metabolism. Temperature, pH, Hunterlab color reflectance, sarcomere length and lactate concentration were measured during ageing. Shear force was measured on aged (7 d) muscle only. Low voltage electrical stimulation increased glycolytic rate as indicated by significantly (P < 0.05) lower pH and higher L-lactate concentrations of stimulated muscles as compared to control muscles. Total and sarcoplasmic protein solubilities decreased due to ageing, and myofibrillar protein solubility increased; however, collagen solubilities were unchanged. Low voltage electrical stimulation did not affect color reflectance, sarcomere length or shear force, indicating that an increased rate of glycolysis alone was not sufficient to effect increases in meat tenderness. Key words: Beef, electrical stimulation, meat quality, muscle

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Дисертації з теми "Muscle ageing"

Smith, N. "Thiol signalling in skeletal muscle ageing." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3026986/.

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An age-related loss of muscle mass is associated with increased frailty in the elderly. The effect is felt at both a national scale, with an increased budgetary demand for health services directed towards the ageing population, and by the individual where reduced mobility significantly reduces their quality of life. It is unclear whether all skeletal muscle types are affected in the same manner. This thesis considered how thiol signalling, facilitated through reactive thiol groups on cysteine amino acids, may affect skeletal muscle ageing as it is crucial for normal intracellular function. Several studies have identified reactive oxygen species (ROS) as crucial signalling molecules in healthy muscle and various proteins can detect and respond to changes in their concentration. The cysteines are evolutionarily conserved in functionally important locations and have a direct impact on protein function, affecting either its active site or conformation. In healthy muscle, proteins can quickly and efficiently respond to changes in ROS concentrations via this mechanism whereas in aged muscle these responses appear to be impaired. The quadriceps and soleus muscles were selected because of their differing primary metabolic pathways and physiology, reflecting fast and slow twitch muscle respectively. This enabled determination of age related changes to the redox proteome between two different skeletal muscles. They are hypothesised to age differently and to determine this, adult (12 months) and old (24 months) tissue were subjected to a deep proteomics investigation, elucidating changes to the global proteome of ageing mouse muscle as well as using differential labelling of reduced and reversibly oxidised cysteine residues to identify redox-susceptible locations on individual proteins. Prior to this a proteomics study had not analysed changes to the redox proteome between two skeletal muscle tissues before. Analysis of the quadriceps label free results identified changes to redox protein abundance such as a significant increase in Protein Disulphide Isomerase, crucial to disulphide bond formation and breakage. HSC70, important for protein folding, was significantly decreased with age. Differential labelling of specific cysteine residues demonstrated Cys46 increased in its reduced form with age in PARK7. Furthermore, many changes observed in the label free analysis highlighted cytoskeletal proteins as those primarily affected. The soleus label free results demonstrated significant decreases in abundance of a number of mitochondrial proteins involved in the electron transport chain such as NAD(P)H dehydrogenase and ATP Synthase. One example of differential labelling highlighted ATP Synthase Cys101 as becoming increasingly reduced with age. This increase in a reduced redox state of cysteines was observed across a range of other mitochondrial proteins, possibly indicating a negative impact on energy metabolism in the soleus with age. A successful preliminary study considered the effect of stretching C2C12 mouse skeletal muscle cells in vitro. A protocol for testing the effect of mechanical stretching on C2C12 cells was optimised with a future goal of producing replicable in vitro proteomics data and thereby reducing the requirement for animal tissue. The studies in this thesis identified various redox proteome changes in quadriceps and soleus muscle with age. This data will provide a basis for a targeted analysis of musculoskeletal proteins with a view to a better understanding of musculoskeletal ageing and its impact via the proteome.

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Sharples, Adam Philip. "The cellular and molecular regulation of skeletal muscle: The ageing muscle cell." Thesis, Manchester Metropolitan University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528373.

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Wredenberg, Anna. "Mitochondrial dysfunction in ageing and degenerative disease /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-311-5/.

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Mills, Matthew. "Changes in muscle function and performance with age." Thesis, University College London (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310522.

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Ghadiali, R. "The role of heparan sulfate in muscle differentiation and ageing." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3007367/.

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O'Neill, Elaine. "The effect of insulin resistance on ageing of skeletal muscle." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539510.

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Nicoll, Baines Katie Mhairi. "Muscle energetics and ageing in the context of RYR1 variants." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/17288/.

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In aged muscle, from humans and mice, the ryanodine receptor (RyR1) is leaky, leading to increased levels of resting Ca2+ in the myoplasm. This is also a feature of skeletal muscle disorders caused by variants in RyR1 such as malignant hyperthermia (MH), central core disease (CCD), exertional heat illness (EHI) and late-onset axial myopathy (LOAM). Elevated Ca2+ is damaging to mitochondria, leading to production of reactive oxygen and nitrogen species associated with MH susceptibility to inhalational anaesthetics. Mice with Ryr1 variants show premature muscle ageing and highlight the cycle of inefficient calcium handling and oxidative damage to mitochondria that impairs skeletal muscle energetics. Caenorhabditis elegans models of MH CCD EHI and LOAM variants, both homozygous and heterozygous forms, showed increased sensitivity to halothane. Altered caffeine sensitivity was evident in MH and CCD models, and at very high concentrations in EHI models. Strains with RyR1 variants exhibit age-related accelerated myosin disorganisation. Whole genome Affymetrix arrays revealed genes and pathways correlated with skeletal muscle ageing and MH. Of additional genes of interest investigated UNC13, CASQ1, ORAI1, MCU and MICU1 showed altered expression with age. Array data from blood has been used to identify a signature for MH susceptibility. There is loss of mitochondrial membrane integrity and alteration in mitochondrial number in MH. New apparatus, capable of quantifying heat produced during muscle contraction, has enabled calculation of skeletal muscle efficiency. Preliminary data indicates that there was loss of skeletal muscle efficiency in aged muscle from wild type mice. This work provides new information on the role of RYR1 variants in skeletal muscle ageing and the importance of calcium handling in muscle energetics.

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Qaisar, Rizwan. "Myonuclear Organization and Regulation of Muscle Contraction in Single Muscle Fibres : Effects of Ageing, Gender, Species, Endocrine Factors and Muscle Size." Doctoral thesis, Uppsala universitet, Klinisk neurofysiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-167723.

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The skeletal muscle fibre is a syncitium where each myonucleus regulates the gene products in a finite volume of cytoplasm i.e., the myonuclear domain (MND). A novel image analysis algorithm applied to confocal images, analyzing MND size and myonuclear spatial distribution in 3-dimensions in single skeletal muscle fibres has been used in this project. The goal was to explore the modulation of myonuclei count and MND size in response to muscle adaptation processes. The effects of ageing, gender, hormones, muscle hypertrophy and body size were investigated on MND size. A strong linear relationship was found between MND size and body size in the muscle fibres from mammals representing a 100,000-fold difference in body size. Independent of species, MND size was highly dependent on MyHC isoform type and mitochondrial contents of skeletal muscle fibres. In hypertrophic mice, a significant effect of MND size on specific force and myosin content was observed. This effect was muscle fibre type-specific and shows that the bigger MNDs in fast-twitch EDL muscle fibres are optimally tuned for force production while smaller MNDs in slow-twitch soleus muscle fibres have a much more dynamic range of hypertrophy without functional compromise. This indicates a critical volume individual myonuclei can support efficiently for a proportional gain in muscle fibre force and size. In human muscle fibres, spatial organization of myonuclei was affected by both ageing and MyHC isoform expression. In fibres expressing type I MyHC isoform, an increased MND size variability and myonuclear aggregates were observed in old age although average MND size was unchanged. In contrast, in type IIa fibres, the average MND size was smaller reflecting smaller size of muscle fibres. Those changes may influence the transcriptional activity per myonucleus and/or local cooperatively of myonuclei in a gender and muscle fibre-type specific manner. Finally, hormone replacement therapy was shown to negate menopause-related functional impairment in skeletal muscle fibres. The positive effect on force was due to quantitative effect in fibres expressing fast myosin isoform while the effect was both quantitative and qualitative in fibres expressing slow myosin isoform. The effect on MND size was fibre type dependent and was achieved by significantly reducing domain size in slow- but not the fast-twitch muscle fibres. Together, our data suggest that modulation of myonuclei count and MND size is a mechanism contributing to remodelling of skeletal muscle in muscle adaptation process. These findings should be considered when developing therapeutic approaches towards restoring muscle mass and strength in muscle wasting conditions.

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Cristea, Alexander. "Effects of Ageing and Physical Activity on Regulation of Muscle Contraction." Doctoral thesis, Uppsala University, Department of Neuroscience, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9198.

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The aims of this study were to investigate the mechanisms underlying (1) the ageing-related motor handicap at the whole muscle, cellular, contractile protein and myonuclear levels; and (2) ageing-related differences in muscle adaptability.

In vivo muscles function was studied in the knee extensors. Decreases were observed in isokinetic and isometric torque outputs in old age in the sedentary men and women and elite master sprinters. A 20-week long specific sprint and resistance training successfully improved the maximal isometric force and rate of force development in a subgroup of master sprinters.

In vitro measurements were performed in muscle biopsies from the vastus lateralis muscle. Immunocytochemical and contractile measurements in single membrane permeabilized muscle fibres demonstrated ageing- and gender-related changes at the myofibrillar level. In sedentary subjects, data showed a preferential decrease in the size of muscle fibres expressing type IIa MyHC in men, lower force generating capacity in muscle fibres expressing the type I MyHC isoform in both men and women and lower maximum velocity of unloaded shortening (V₀) in fibres expressing types I and IIa MyHC isoforms in both men and women. The master sprinters also experienced the typical ageing-related reduction in the size of fast-twitch fibres, a shift toward a slower MyHC isoform profile and a lower V₀ of type I MyHC fibres, which played a role in the decline in explosive force production capacity. The fast-twitch fibre area increased after the resistance training period. A model combining single muscle fibre confocal microscopy with a novel algorithm for 3D imaging of myonuclei in single muscle fibre segments was introduced to study the spatial organisation of myonuclei and the size of individual myonuclear domains (MNDs). Significant changes in the MND size variability and myonuclear organization were observed in old age, irrespective gender and fibre type. Those changes may influence the local quantity of specific proteins per muscle fibre volume by decreased and/or local cooperativity of myonuclei in a gender and muscle fibre specific manner.

In conclusion, the ageing-related impairments in in vivo muscle function were related to significant changes in morphology, contractile protein expression and regulation at the muscle fibre level. It is suggested that the altered myonuclear organisation observed in old age impacts on muscle fibre protein synthesis and degradation with consequences for the ageing-related changes in skeletal muscle structure and function. However, the improved muscle function in response to a 20-week intense physical training regime in highly motivated physically active old subjects demonstrates that all ageing-related in muscle function are not immutable.

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Markiewicz, Filip. "Vibration, motor deficit, and the effect of ageing on muscle function." Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/417939/.

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Mechanical vibrations are common in today’s world. Studies have claimed that vibration training can enhance skeletal muscle performance and might be a useful therapy for sarcopenia, the age-related degeneration of muscle function and mass. Others, however, report debilitating consequences following excessive vibration exposure, such as Hand-Arm Vibration Syndrome. Further to this ambiguity, few studies have explored the function of skeletal muscles during vibration. Animal models are integral to furthering our understanding of the effects of vibration, and while efforts to reduce the use of vertebrate models are increasing, invertebrates may prove to be valuable alternatives. The contractile dynamics of the locust’s metathoracic extensor tibiae muscle were compared to the soleus and extensor digitorum longus muscles of C57 mice and then subjected to acute vibration, during which their contraction dynamics were analysed. The influence of sensory feedback, stimulus phase, vibration frequency and amplitude on the locust extensor tibiae muscle’s function were also analysed. Additionally, the effects of locust age on its behaviour, extensor tibiae muscle function and response to vibration were studied to determine whether it may provide insights into sarcopenia. The locust’s extensor tibiae muscle demonstrated higher peak forces than both murine muscles, but its force-frequency relationship showed a greater resemblance to that of the soleus muscle. The function of the extensor tibiae and soleus muscles were dependent on stimulus phase, frequency and amplitude of vibration treatments, and sensory feedback was shown to reduce the impact of vibration on the locust muscle. No behavioural changes or decreases in the extensor tibiae muscle’s mass were found in ageing locusts, but age-dependent variations in its contractile function and the neuromuscular response to vibration were measured. This work suggests that both vertebrate and invertebrate muscle function are compromised during vibration, and additional work utilising the locust as a model may further our understanding of the effects of vibration and ageing on the neuromuscular system.

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Книги з теми "Muscle ageing"

Blanchard, Christal. Calcineurin signaling in ageing skeletal muscle. Sudbury, Ont: Laurentian University, 2005.

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Skelton, Dawn. Exercise for healthy ageing: Exercise programmes proven in research to increase muscle strength. 2nd ed. London: Research into Ageing, 1998.

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Kainulainen, Heikki. Effects of chronic exercise and ageing on regional energy metabolism in heart muscle. Jyväskylä: University of Jyväskylä, 1990.

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Lintz, Yannick. Le Musée des beaux-arts, Agen. Paris: Fondation BNP Paribas, 2000.

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Yannick, Lintz, Nivière Marie-Dominique, Amandry Michel, and Aboussouan Camille, eds. Visions d'Orient: Des cités mésopotamiennes à la Jérusalem des croisés : la donation Camille Aboussouan. Paris: Réunion des musées nationaux, 2002.

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Echenberg, Margo. The Fame of Sor Juana Inés de la Cruz. Nieuwe Prinsengracht 89 1018 VR Amsterdam Nederland: Amsterdam University Press, 2023. http://dx.doi.org/10.5117/9789463727044.

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The Fame of Sor Juana Inés de la Cruz traces the meteoric trajectory of the Mexican Tenth Muse’s renown and studies how her worldly celebrity was altered posthumously by elegists in her Fama y obras póstumas [Fame and Posthumous Works] of 1700. In this study of a polyphonic, transatlantic volume, the didactic framework of early modern fame is pushed to its limits as panegyrists inscribe the nun into an evolving world-view that could trade in the fictions of the saintly exemplar, the Tenth Muse or a New World treasure, but could not preserve a woman’s renown on the grounds of authorship. Only by making her legible could she vie for the promise of posthumous fame. In flushing out the machinations of Sor Juana’s role as agent of her own celebrity as well as the negotiations of her contemporaries, this book opens new lines of inquiry in the study of early modern fame and print culture and the role of writers, panegyrists and editors as cultural agents in the transatlantic literary relationship between Mexico and Spain.

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1967-, Sandell Richard, Dodd Jocelyn, and Garland-Thomson Rosemarie, eds. Re-presenting disability: Activism and agency in the museum. New York: Routledge, 2010.

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1967-, Sandell Richard, Dodd Jocelyn, and Garland-Thompson Rosemarie, eds. Re-presenting disability: Activism and agency in the museum. New York: Routledge, 2010.

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Dinser, Robert, and Ulf Müller-Ladner. Skeletal muscle physiology and damage. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0055.

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This chapter summarizes muscle structure and physiology, the genesis and adaptions of muscle throughout life, and clinical assessment of muscle disease. The anatomical and molecular structure of muscle tissue is described, as well as the basic function of the neuromuscular junction, the energy metabolism of muscle tissue, and the mechanisms of fatigue. Key elements of embryological myogenesis, the adaptions of muscle to exercise and damage, and physiological ageing are depicted. A summary of the clinical analysis of muscle function including laboratory, electrophysiological, and imaging testing is provided.

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Dinser, Robert, and Ulf Müller-Ladner. Skeletal muscle physiology and damage. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199642489.003.0055_update_001.

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Частини книг з теми "Muscle ageing"

Carvalho, Joana, Elisa Marques, and Pedro Moreira. "Bone and muscle ageing." In Anti-ageing nutrients, 247–76. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118823408.ch7.

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Gao, Yuansheng. "Ageing and Vasoreactivity." In Biology of Vascular Smooth Muscle, 401–24. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-7122-8_21.

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Russell, Brenda, and Linda Brubaker. "Muscle Function and Ageing." In Pelvic Floor Re-education, 49–61. London: Springer London, 2008. http://dx.doi.org/10.1007/978-1-84628-505-9_4.

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Thirupathi, Anand, Ricardo A. Pinho, and Yaodong Gu. "Redox Homeostasis in Skeletal Muscle Aging." In Healthy Ageing and Longevity, 87–96. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-84965-8_5.

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Stewart, Claire E. "Ageing Skeletal Muscle: The Ubiquitous Muscle Stem Cell." In Biochemistry and Cell Biology of Ageing: Part III Biomedical Science, 365–77. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-21410-3_14.

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Baylis, Daniel, and Avan Aihie Sayer. "The musculoskeletal system: muscle." In The Biology of Ageing and Its Clinical Implication, 180–97. London: CRC Press, 2022. http://dx.doi.org/10.1201/9781846197925-16.

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Wills-Karp, Marsha. "Effects of Ageing upon Airways Smooth Muscle Contractility." In Airways Smooth Muscle: Development, and Regulation of Contractility, 185–218. Basel: Birkhäuser Basel, 1994. http://dx.doi.org/10.1007/978-3-0348-7408-3_7.

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Argilés, Josep M., Sílvia Busquets, Marcel Orpi, Roberto Serpe, and Francisco J. López-Soriano. "Muscle Wasting in Cancer and Ageing: Cachexia Versus Sarcopenia." In Sarcopenia – Age-Related Muscle Wasting and Weakness, 9–35. Dordrecht: Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-9713-2_2.

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Radák, Z., and S. Goto. "The effects of exercise, ageing and caloric restriction on protein oxidation and DNA damage in skeletal muscle." In Oxidative Stress in Skeletal Muscle, 87–102. Basel: Birkhäuser Basel, 1998. http://dx.doi.org/10.1007/978-3-0348-8958-2_6.

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Taylor, D. J., G. J. Kemp, C. H. Thompson, and G. K. Radda. "Ageing: Effects on oxidative function of skeletal muscle in vivo." In Detection of Mitochondrial Diseases, 321–24. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-6111-8_48.

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Тези доповідей конференцій з теми "Muscle ageing"

Lakhdar, Ramzi, Ellen Drost, Paul G. Shiels, William MacNee, and Roberto Rabinovich. "Markers of ageing in the limb muscle of patients with COPD." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa863.

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Santu, Alexandra. "86 Nuclear lamina defects accelerate vascular ageing in a mouse model of smooth muscle cell-specific zmpste24 knockout." In British Cardiovascular Society Annual Conference ‘High Performing Teams’, 4–6 June 2018, Manchester, UK. BMJ Publishing Group Ltd and British Cardiovascular Society, 2018. http://dx.doi.org/10.1136/heartjnl-2018-bcs.86.

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Mochalova, N. V., N. D. Kreshchenko, G. V. Kuznetsov, N. M. Shalaeva, S. O. Movsesyan, and N. B. Terenina. "THE STUDY OF THE MUSCULAR SYSTEM OF THE TREMATODE DICROCOELIUM LANCEATUM." In THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL. All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”, 2023. http://dx.doi.org/10.31016/978-5-6048555-6-0.2023.24.319-324.

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This paper presents the results of a study of the muscular system of the trematode D. lanceatum, the causative agent of dicrocoeliosis, a widespread parasitic disease of the grass-feeding ruminants. As a result of the used fluorophore-conjugated phalloidin, data were obtained on the organized muscles of the body wall, attachment organs, and digestive, reproductive and excretory systems of D. lanceatum. The body wall musculature is represented by three layers of muscle fibers: circular, longitudinal and diagonal. The character of the muscle fiber location is different in the anterior, middle and posterior parts of the body. The paper describes several types of muscle fibers found in the oral and ventral suckers, and digestive, reproductive and excretory systems of the parasite. An analysis of the data obtained and available in the literature showed the presence, along with common features, of differences in the organization of the muscular system of various trematode species. The results obtained expand and deepen the understanding of the trematode morphology, the organization of their muscular system, and make it possible to detect similar and different features in the structure of the muscular system of organs and tissues of species of various taxonomic groups of trematodes. In addition, the study of the muscular system of trematodes may be important in identifying new additional diagnostic criteria necessary for solving a number of taxonomic tasks.

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Khataee, H. R., T. N. Mohd Aris, and M. N. Sulaiman. "A software agent model of muscle myosin nanomotor." In 2011 International Conference on Research and Innovation in Information Systems (ICRIIS). IEEE, 2011. http://dx.doi.org/10.1109/icriis.2011.6125740.

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Al-Jumaily, A. M., M. Mathur, and M. J. Jo-Avila. "Enhancement of Bronchodilation Using Length Oscillations." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80080.

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In asthma treatment β-agonists such as isoproterenol are used for their ability to relax airway smooth muscle (ASM) through stimulation of cAMP production. In vitro experiments conducted on ASM tissues suggest that length oscillations applied to contracted muscle result in a reduction in the contractile ability of the tissue. Conducting experiments on tissues from two different species leads to a fact that length oscillation enhances ASM relaxation induced by β-agonists agent independent of the species.

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Moussa, Heba Adel Mohamed Lotfy, Gawaher Saleh Abbas Mahgoub, Mashael Ali H. I. Al-Badr, and Huseyin Cagatay Yalcin. "Investigating the Cardiac Effects of Sildenafil loaded Nanoparticles on Heart Failure using the Zebrafish Embryo Model." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0217.

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Background: Cardiovascular diseases (CVDs) are the first cause of death worldwide. Vasolidator agents are used to relax cardiac muscle, but their extremely short half-lifes limit their effectiveness. Sildenafil is such an agent used to relax the blood vessels muscles and increase the blood flow. The conventional drug can lead to serious problems in patients duo to the systematic drug delivery. Use of Nanomedicine potentially can enhance delivery of this agent while reducing the systematic effect of the drug. Aim: The purpose of the research is to examine the effectiveness sildenafil loaded nanoparticles in rescuing heart failure using zebrafish embryo model. Methods: There will be five experimental groups. The zebrafish will be treated with Aristolochic Acid (AA) at 24 hour per fertilization (hpf) to create the heart injury group. The treatment groups will be heart injury followed by a dose of either Sildenafil or Sildenafil loaded nanoparticles at 36 hpf. Two control groups will be the negative control (exposed to egg water) and vehicle control (exposed to the Dimethylsulfoxide (DMSO)).To evaluate the drug effects on embryo, toxicity assessment (Survival rate, tail flicking and hatching rate), cardiotoxicity assessment and gene expression of heart injury marker via RT-PCR will be conducted. Results: Preliminary findings demonstrate, loading Sildenafil to nanoparticles enhances its effectiveness dramatically. The experiments are ongoing to confirm the results. Conclusion: Nanomedicine is a powerful approach to enhance cardiovascular therapy. Vasodilator drugs in particular will benefit from this improvement as demonstrated with our findings

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Vagin, N. A., N. S. Malysheva, and N. A. Samofalova. "INFECTION OF RODENTS AND INSECTIVORES WITH TRICHINELLA IN THE KURSK REGION." In THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL. All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”, 2023. http://dx.doi.org/10.31016/978-5-6048555-6-0.2023.24.117-122.

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The study of the Trichinella distribution in representatives of different systematic taxa is quite relevant as it allows us to establish the role of infected animals in the functioning of the parasitic system of the causative agent of trichinellosis. Scientific works contain contradictory information on the presence of the Trichinella infection in rodents and insectivores. Many scientists publish data on the detection of Trichinella in species of these orders of mammals. There is a large number of works showing the absence of the Trichinella invasion in different species of rodents and insectivores. The purpose of our research was to study the Trichinella infection rate in rodents and insectivores in the Kursk Region. Trichinella larvae were detected by compressor trichinelloscopy and by the method of digesting muscle tissue in artificial gastric juice. Capsule-forming Trichinella (Trichinella spp.) were found in the muscles of infected animals. In total, 7 species of rodents and 5 species of insectivores were studied. The Trichinella invasion was detected in the common vole (1.8%) and in Erinaceus roumanicus (4.2%). The results obtained show that rodents and insectivores are involved in the circulation of Trichinella in the Kursk Region. We believe that representatives of these orders of animals serve as one of the sources of infection for many species of predatory mammals.

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Wang, Wei, Ke Li, Na Wei, Shouwei Yue, Yang Zhang, and Cuiping Yin. "Effects of ageing on structural variability of EMG in lower-limb muscles during quite standing." In 2017 10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics (CISP-BMEI). IEEE, 2017. http://dx.doi.org/10.1109/cisp-bmei.2017.8302266.

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Khataee, H. R., T. N. Mohd Aris, and M. N. Sulaiman. "An agent-based model of muscle contraction process as a bio-robotic process." In 2011 5th Malaysian Conference in Software Engineering (MySEC). IEEE, 2011. http://dx.doi.org/10.1109/mysec.2011.6140643.

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Niculescu, Andreea I., Kheng Hui Yeo, and Rafael Enrique Banchs. "Designing MUSE." In HAI '16: The Fourth International Conference on Human Agent Interaction. New York, NY, USA: ACM, 2016. http://dx.doi.org/10.1145/2974804.2980521.

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