Готові списки джерел за темами / Multicentric

Добірка наукової літератури з теми "Multicentric"

Автор: Grafiati
Опубліковано: 7 липня 2024

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Зміст

  1. Статті в журналах
  2. Дисертації
  3. Книги
  4. Частини книг
  5. Тези доповідей конференцій
  6. Звіти організацій

Статті в журналах з теми "Multicentric":

1

HIGUCHI, Mutsumi, Masakazu TAKAHARA, Yoichi MOROI, Masutaka FURUE, Akari TASHIRO, Hiroaki NISHIZAKA, and Satoko SHIBATA. "A Case of Multicentric Reticulohistiocytosis." Nishi Nihon Hifuka 74, no. 3 (2012): 273–77. http://dx.doi.org/10.2336/nishinihonhifu.74.273.

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2

NAKAHARA, Tomoko, Takasuke OGAWA, Atsushi TAKAGI, Nobuhiro TSUKADA, Norio KOMATSU, Masaru HOSONE, and Sigaku IKEDA. "A case of multicentric Castleman's disease." Skin Cancer 27, no. 2 (2012): 211–14. http://dx.doi.org/10.5227/skincancer.27.211.

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3

Kaul, Arvind, SunilN Tolat, Vasudha Belgaumkar, and ChandrakantB Mhaske. "Multicentric reticulohistiocytosis." Indian Journal of Dermatology, Venereology, and Leprology 76, no. 4 (2010): 404. http://dx.doi.org/10.4103/0378-6323.66598.

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4

Shah, SejalP, SachinM Prajapati, AdityaM Shah, and FrenyE Bilimoria. "Multicentric reticulohistiocytosis." Indian Dermatology Online Journal 2, no. 2 (2011): 85. http://dx.doi.org/10.4103/2229-5178.85998.

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5

Haridas, Vikram, and Kiran Haridas. "Multicentric Reticulohistiocytosis." Journal of Case Reports 5, no. 1 (April 15, 2015): 160–62. http://dx.doi.org/10.17659/01.2015.0040.

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6

MIYAZAWA, Nobuhiko, Reizou Tsuji, Shigeru MITSUKA, Ryo-ichi KIMURA, Akira FUKAMACHI, and Hideaki NUKUI. "Multicentric Glioma." Neurologia medico-chirurgica 28, no. 5 (1988): 481–85. http://dx.doi.org/10.2176/nmc.28.481.

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7

OWLIA, Mohammad Bagher, Golbarg MEHRPOOR, and Hossein SOLEIMANI. "Multicentric reticulohistiocytosis." APLAR Journal of Rheumatology 10, no. 4 (December 5, 2007): 330–32. http://dx.doi.org/10.1111/j.1479-8077.2007.00318.x.

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8

Salisbury, Jonathan R., Peter A. Hall, Hywel C. Williams, Manzoor H. Mangi, and Ghulam J. Mufti. "Multicentric Reticulohistiocytosis." American Journal of Surgical Pathology 14, no. 7 (July 1990): 687–93. http://dx.doi.org/10.1097/00000478-199007000-00009.

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9

Kuwabara, Hiroko, Hirotsugu Uda, and Sumiko Tanaka. "Multicentric Reticulohistiocytosis." Pathology International 42, no. 2 (December 12, 2008): 130–35. http://dx.doi.org/10.1111/j.1440-1827.1992.tb03088.x.

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10

Luz, FB, AP Gaspar, N. Kalil-Gaspar, and M. Ramos-e-Silva. "Multicentric reticulohistiocytosis." Journal of the European Academy of Dermatology and Venereology 15, no. 6 (November 2001): 524–31. http://dx.doi.org/10.1046/j.1468-3083.2001.00362.x.

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Статті в журналах Дисертації Книги

Дисертації з теми "Multicentric":

1

Takahashi(Mizuguchi), Aya. "Genetic features of multicentric/multifocal intramucosal gastric carcinoma." Kyoto University, 2019. http://hdl.handle.net/2433/243290.

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2

Lim, Stephen Chin Ming. "Asian Biblical hermeneutics as multicentric dialogue : towards a Singaporean way of reading." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/asian-biblical-hermeneutics-as-multicentric-dialogue(a5c5fd43-270c-4e07-bd6b-412442d61364).html.

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In this thesis, I propose a way of reading the Bible in the context of Singapore which is my country of origin. My understanding of context draws in what decolonial thinkers, Anibal Quijano (2007) and Walter Mignolo (2012) have argued to be the modern/colonial world system and social epistemologist, Jose Medina’s (2006) polyphonic contextualism. This allows me to better situate the contextual reader within current networks of knowledge production and argue for the goals of reading the Bible in Singapore to be transformative praxis and identity formation. With the understanding of Singapore as an epistemic terrain embedded in global and local networks of knowledge production, I outline the hermeneutical norms that control contextual reading of the Bible in chapter 2. In order to better aid the task of constructing this hermeneutic, I also survey scholarship on biblical hermeneutics in chapter 3 both in the West and Asia to distil important considerations and useful reading strategies. With these considerations in mind, I propose that reading the Bible in context requires at the metatheoretical level a negotiation between western, Asian and Singaporean standpoints in chapter 4. This is facilitated by a conscientisation framework that checks the posture of specialist readers in relation to nonspecialist readers in a specific context so as to ensure submerged voices are not silenced in favour of dominant epistemologies; and a conversation framework that facilitates understanding the Other that tries to avoid Orientalist and nativist/nationalist dangers. In chapter 5, I then test the proposed method through reading the stories of Daniel to see the discursive effects such a reading strategy has on issues I outline in the analysis of my context pertaining to praxis and identity. In my final chapter, I reflect on how the reading exercise impacts on my proposed understanding of Bible and Singapore. I show that it fundamentally shifts the understanding of the Bible to what Justin Ukpong (2002) argues to be a ‘site of struggle’ and an inclusive canon that is hospitable to the many voices, especially of the marginalised in my context of Singapore.
3

Boriani, Filippo <1977&gt. "The "Orthoplastic" combined surgical approach to open tibia fractures: a multicentric prospective outcome study." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6754/4/tesidottorato22%EF%80%A212%EF%80%A22014.pdf.

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Introduction: Open fractures of the leg represent a severe trauma. The combined approach, shared between plastic and orthopaedic surgeons, is considered to be important, although this multidisciplinary treatment is not routinely performed. Aim of this study was to verify whether the orthoplastic treatment is of any advantage over the traditional simply orthopedic treatment, through a multicentric inclusion of these unfrequent injuries into a prospective study. Material and methods: The following trauma centres were involved: Rizzoli Orthopaedic Institute/University of Bologna (leading centre) and Maggiore Hospital (Bologna, Italy), Frenchay Hospital (Bristol, United Kingdom), Jinnah Hospital (Lahore, Pakistan). All patients consecutively hospitalized in the mentioned centres between January 2012 and December 2013 due to tibial open fractures were included in the study and prospectively followed up to December 2014. Demographics and other clinical features were recorded, including the type of treatment (orthopaedic or orthoplastic). The considered outcome measures included duration of hospitalization, time for bone union and soft tissue closure, Enneking score at 3, 6 and 12 months, the incidence of osteomyelitis and other complications. Results: A total of 164 patients were included in the study. Out of them 68% were treated with an orthoplastic approach, whereas 32% received a purely orthopedic treatment. All considered outcome measures showed to be improved by the orthoplastic approach, compared to the orthopaedic one: time for soft tissue closure (2 versus 25 weeks), duration of hospital stay (22 versus 55 days), time for bone union (6 versus 8.5 months) , number of additional operations (0.6 versus 1.2) and functional recovery of the limb at 12 months (27 versus 19, Enneking’s score). All results were statistically significant. Conclusion: The combined orthoplastic approach to the treatment of open tibia fractures, in particular for high grade injuries (Gustilo 3B), is proven to improve the outcome of these severe injuries.
4

Boriani, Filippo <1977&gt. "The "Orthoplastic" combined surgical approach to open tibia fractures: a multicentric prospective outcome study." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6754/.

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Анотація:
Introduction: Open fractures of the leg represent a severe trauma. The combined approach, shared between plastic and orthopaedic surgeons, is considered to be important, although this multidisciplinary treatment is not routinely performed. Aim of this study was to verify whether the orthoplastic treatment is of any advantage over the traditional simply orthopedic treatment, through a multicentric inclusion of these unfrequent injuries into a prospective study. Material and methods: The following trauma centres were involved: Rizzoli Orthopaedic Institute/University of Bologna (leading centre) and Maggiore Hospital (Bologna, Italy), Frenchay Hospital (Bristol, United Kingdom), Jinnah Hospital (Lahore, Pakistan). All patients consecutively hospitalized in the mentioned centres between January 2012 and December 2013 due to tibial open fractures were included in the study and prospectively followed up to December 2014. Demographics and other clinical features were recorded, including the type of treatment (orthopaedic or orthoplastic). The considered outcome measures included duration of hospitalization, time for bone union and soft tissue closure, Enneking score at 3, 6 and 12 months, the incidence of osteomyelitis and other complications. Results: A total of 164 patients were included in the study. Out of them 68% were treated with an orthoplastic approach, whereas 32% received a purely orthopedic treatment. All considered outcome measures showed to be improved by the orthoplastic approach, compared to the orthopaedic one: time for soft tissue closure (2 versus 25 weeks), duration of hospital stay (22 versus 55 days), time for bone union (6 versus 8.5 months) , number of additional operations (0.6 versus 1.2) and functional recovery of the limb at 12 months (27 versus 19, Enneking’s score). All results were statistically significant. Conclusion: The combined orthoplastic approach to the treatment of open tibia fractures, in particular for high grade injuries (Gustilo 3B), is proven to improve the outcome of these severe injuries.
5

Zhang, Wei Hong. "The Strengths and challenges of multicentric European epidemiological projects in the field of reproductive health." Doctoral thesis, Universite Libre de Bruxelles, 2007. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210700.

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In this dissertation, we base our experience of carrying out participation in 4 EU-funded projects: EUROFETUS (Cost-Effectiveness of ultrasound screening for congenital anomalies); MOMS-B (MOther Mortality and Severe morbidity); PERISTAT(Monitoring and evaluating perinatal health) and EUPHRATES (EUropean Project on obstetric Haemorrhage Reduction: Attitudes, Trial, and Early warning System), an online questionnaire survey for researchers and a literature review, to provide results which will help us to understand the added value and the challenges of the EU collaboration research and the challenges of EU collaboration research in improving the quality and the accessibility of reproductive healthcare.

The EUROFETUS project showed that, despite the fact that the birth prevalence of congenital anomalies has been declining during the last twenty years, they are still a major cause of perinatal mortality and childhood disability in Europe. Congenital heart defects were among the most frequent and the most severe malformations, but were the least diagnosed prenatally. There was large variation between and within countries regarding the proportion of cases diagnosed prenatally and the proportion of cases resulting in termination of pregnancy. From the data available in Eurofetus, such variation might result from the cultural differences underling policy or on ultrasonographer’s expertise, or on differing interpretation of scientific evidence in the design and implementation of screening.

The MOMS-B project allowed population-based comparisons between countries by using the standardised definition that showed the three conditions (pre-eclampsia, postpartum haemorrhage and sepsis) selected to as markers of acute severe maternal morbidity are not rare in Europe. Severe haemorrhage was the most common of severe maternal morbidity condition, but its incidence varied widely between European countries.

The PERISTAT project on the indicators of unfavourable maternal health outcome showed that the maternal mortality ratios (per 100, 000 live births) for early obstetric death ranged from 2.8 to 11.4 across European countries studied. Such variation reflected different resources and systems in place with varying level of ascertainment in addition to difference in the number of maternal deaths.

The EUPHRATES project on a survey of current practice in relation to management of the third stage of labour and the immediate management of postpartum haemorrhage in 14 European countries showed that there were considerable differences in policies for managing the third stage of labour between and within the countries studied.

The online questionnaire survey for researchers showed that almost all researchers were satisfied with their participation in EU-funded project; the main benefits for them were transfer and sharing of experience and knowledge between researchers, but the administrative procedures should be simplified in the future. The description of the process needed to obtain ethical approval for a cluster randomized trial in the EUPHRATES project showed that there was considerable variation in time required and the criteria used amongst 14 European countries, with consequential delay in research and exclusion of one country from the trial.

Overall, we conclude that Community Framework programmes offer new opportunities to connect researchers from all over Europe to share expertise and resources, including computing tools, and make a real contribution to the creation of the European research area. The added value of EU collaborative research is particularly well positioned for improving foetal and maternal health, from the perspective of harmonizing case definitions, collecting the necessary number of cases within a limited period of time, comparing data between regions and countries, meeting the specific needs of the EU and giving a common response to European reproductive health questions. On the other hand, epidemiological data from multiple countries has advanced our understanding of important health-risks and their geographical distributions across Europe and provided the evidence to help people make better decisions about healthcare in the field of reproductive health for the future research.

We focus on reproductive health but believe that this approach could be adapted to other fields when appropriate./Dans cette thèse, nous avons basé notre expérience sur notre participation dans 4 projets européens (EUROFETUS, MOMS-B, PERISTAT et EUPHRATES), un questionnaire en ligne vers les chercheurs, et une revue de la littérature pour fournir les résultats qui nous aideront à comprendre la valeur ajoutée qu’apporte la recherche collaborative et les défis de cette recherche pour l’amélioration de la qualité et de l’accessibilité de la santé reproductive.

Le projet EUROFETUS montre que, en dépit du fait que la prévalence des anomalies congénitales à la naissance diminue depuis une vingtaine d’années, elles restent une cause majeure de mortalité périnatale et de handicaps infantiles. Les malformations cardiaques congénitales sont parmi les plus fréquentes et les plus sévères des malformations, mais aussi les moins diagnostiquées. Il y a de larges différences entre et à l’intérieur des pays concernant la proportion de cas diagnostiqués en prénatal et la proportion de cas résultant en interruption de grossesse. D’après les données disponibles dans EUROFETUS, de telles variations pourraient résulter de politiques de santé différentes, reflétant des divergences culturelles, de variations dans l’expertise des échographistes, ou encore d’interprétations divergentes de preuves scientifiques dans la conception ou la mise en place du screening.

Le projet collaboratif européen sur la Mortalité et la Morbidité Maternelle sévère (MOMB-B) a permis des comparaisons en population entre pays en utilisant une définition standardisée qui a montré que les trois pathologies sélectionnées (pré-éclampsie, hémorragie, sepsis) comme marqueurs de la morbidité maternelle sévère n’étaient pas rares en Europe. L’hémorragie sévère était la pathologie la plus fréquente, mais son incidence variait très fort d’un pays à l’autre.

The PERISTAT project on the indicators of unfavourable maternal health outcome showed that the maternal mortality ratios (per 100, 000 live births) for early obstetric death ranged from 2.8 to 11.4 across European countries studied. Such variation reflected different resources and systems in place with varying level of ascertainment in addition to difference in the number of maternal deaths.

Le projet EUPHRATES, par une enquête de pratique concernant le management de la troisième phase du travail et du management immédiat de l’hémorragie du postpartum dans 14 pays européens, a montré qu’il y avait des différences considérables dans les pratiques entre et à l’intérieur des pays en Europe.

Le questionnaire en ligne auprès des chercheurs a montré que la plupart étaient satisfaits de leur participation à des projets européens, les principaux bénéfices étaient le transfert et le partage d’expériences et de connaissances entre chercheurs mais que les procédures administratives devraient être simplifiées dans le futur. La description de l’utilisation des comités d’éthique dans l’essai EUPHRATES a montré de très grandes divergences.

En général, nous concluons que les programmes-cadres européens offrent de nouvelles opportunités aux chercheurs européens de partager l’expertise et les moyens, en ce compris les outils informatiques et contribuent à la création d’un espace européen de la recherche. La valeur ajoutée de la recherche collaborative est particulièrement importante pour améliorer la santé fœtale et maternelle par l’harmonisation de la définition des cas, la collecte du nombre nécessaire de cas dans une période déterminée, la comparaison des données entre les régions et pays, pour rencontrer les besoins spécifiques de l’Union Européenne et donner une réponse commune aux questions de santé reproductive en Europe. D’autre part, les données épidémiologiques de nombreux pays ont fait avancer notre compréhension de risques importants de santé maternelle et leur distribution géographique à travers l’Europe et apporté la preuve de la nécessité d’aider les gens à prendre la meilleure décision en ce qui concerne les soins en santé reproductive pour de futures recherches.

Nous nous sommes concentrés sur la santé reproductive mais nous croyons que cette approche pourrait être adaptée à d’autres domaines.


Doctorat en Sciences de la santé publique
info:eu-repo/semantics/nonPublished

6

Mongeon, Luc Roland. "The right atrial pacemaker complex: The underlying mechanisms mediating the multicentric origin of atrial depolarization." Case Western Reserve University School of Graduate Studies / OhioLINK, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=case1060777680.

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7

MOSCATO, GIUSELLA. "Epidemiology of nosocomial infections in intensive care units in Rome (Italy): a multicentric prospective study." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2013. http://hdl.handle.net/2108/209994.

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Objective: This study investigated BSI incidence in the Intensive Care Unit and their impact on the mortality rate compared with others causes. As primary point it has been evaluated the rate of bacteremia per year, the causative organisms, the outcome of infection, the antimicrobial susceptibility patterns, the risk factors and the prevalence of multi-drug resistant Gram-positive and Gram-negative bacilli. As secondary end point, the study evaluated the most significant predictors of mortality among the usual risk factors for acquiring BSI at the admission in the ICU. Methods and materials: The study included 1,318 patients admitted to ICUs. Demographics characteristics, SAPS II score, comorbidities and BSI isolates data were collected. Crude mortality rate compared with the overall mortality rate for all causes were evaluated. Results: 324 BSIs from 1,318 patients were evaluated with a total of 407 isolates: 48.6% were Gram + , 43.7% Gram – (GNB) and 7.6% Candida spp. Among Gram+, 69.1% were Coagulase negative Staphylococci (CoNS), 21.7% Enterococci, 6% S. aureus. Among GNB, 30.8% were K. pneumoniae, 28.8% A. baumannii, 17.4% P. aeruginosa, and 6.7% E. coli. At least one episode of BSI was developed in 175 patients (132/1000 pts/year): 139/175 pts had a monomicrobial BSI and 36/175 had polymicrobial BSI. The overall mortality rate was 25.4%: 82/175 pts with BSI died, (44.4% of pts with monomicrobial BSI vs. 61.1 % of pts with polymicrobial BSI). At univariate analysis, SAPS II score (p = 0.039, OR 1.03, 1.001-1.06 CI), cardiac illness (p = 0.015, OR 2.5, 1.20-5.42 CI), and K.pneumoniae BSI (p= 0.005, OR 2.96, 1.37-6.37 CI) were significantly associated to higher risk of death. A slightly significant association between a polymicrobial bacteremia and a higher risk of death was also found (p= 0.057, OR 2.07, 0.98-4.38 CI). At multivariate analysis, having a K. pneumoniae BSI and cardiac illness at the admission in ICU were confirmed to be significantly associated with higher mortality rate (p= 0.0162 and p= 0.0158 respectively). After stratification for outcome (survivors vs. nonsurvivors), univariate and multivariate analysis were performed. Conclusions: These data suggest that K. pneumoniae BSI , cardiovascular comorbidity and polymicrobial BSI in ICU pts are associated to a higher risk of death.
8

VALENTE, ALESSIA. "Multicentre translational Trial of Remote Ischaemic Conditioning in acute ischaemic Stroke (TRICS)." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2023. https://hdl.handle.net/10281/403045.

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L’ictus rappresenta la seconda causa di morte a livello globale e la prima causa di disabilità negli anziani. A causa di alcuni limiti di impiego, le principali terapie disponibili, volte a ripristinare il flusso sanguigno attraverso fibrinolisi e/o trombectomia meccanica, possono essere usate solo nel 60% dei pazienti con eziologia ischemica. Per tale motivo, la ricerca preclinica cerca di identificare target terapeutici utili per definire nuovi trattamenti ed estendere l’accesso alle cure. Nessuna nuova strategia terapeutica identificata negli studi preclinici ha però confermato la sua efficacia nei trial clinici. I problemi di traslazionalità dipendono da alcuni limiti degli studi preclinici, come l’uso di un ridotto numero di animali, che non rappresentano le condizioni reali dei pazienti o la mancata replicazione dei risultati ottenuti dai singoli laboratori, introducendo così bias metodologici, tra cui la mancanza di protocolli armonizzati. Il presente studio origina dalla necessità di migliorare il valore traslazionale della ricerca preclinica nell’ictus ischemico attraverso la definizione di un multicentre preclinical randomised controlled trial (pRCT), il progetto TRICS, che ha l’obiettivo di valutare l’azione neuroprotettiva del remote ischemic conditioning (RIC) dopo l’evento ischemico. Perché il RIC raggiunga una neuroprotezione significativa, l’outcome primario è che induca un miglioramento dei deficit sensorimotori a 48 ore dall’evento ischemico, calcolati attraverso il De Simoni neuroscore. Lo score valuta i deficit generali, che indicano lo stato di salute dell’animale e i deficit focali selettivamente associati alle conseguenze neurologiche dell’ischemia. Per ridurre al minimo i bias tecnici, il nostro studio ha previsto una prima fase di armonizzazione della valutazione comportamentale tra i centri, mediante analisi della concordanza tra i rater che eseguivano la misura, definita come interrater agreement. Questo è stato calcolato come intraclass correlation coefficient, ICC=0, nessun accordo, a ICC=1, accordo perfetto. Ci siamo posti l’obiettivo di raggiungere un interrater agreement con un ICC≥ 0.60. Una buona concordanza tra i centri è infatti una condizione indispensabile per garantire che tutti applichino lo stesso metodo di valutazione, assicurando l’oggettività, la trasparenza e la riproducibilità dei risultati. Dopo un training sull’esecuzione del De Simoni neuroscore, ogni centro ha indotto l’ischemia cerebrale nell’animale mediante l’occlusione transiente dell’arteria cerebrale media (tMCAo). A 48 ore dall’operazione, tutti gli animali sono stati filmati durante l’esecuzione del test e i video sono stati inviati al centro coordinatore, che li ha randomizzati e inoltrati ai centri. Un rater per ogni centro ha eseguito in cieco il De Simoni neuroscore sui video e sulle valutazioni è stata eseguita l’analisi statistica. Il risultato ottenuto dall’interrater agreement è stato di ICC=0.50 (0.22-0.77) per i topi e ICC=0.49 (0.210.77) per i ratti; non siamo riusciti a raggiungere l’obiettivo prefissato. Questi risultati sono dipesi da alcuni errori nell’esecuzione del test e dall’attribuzione sbagliata dei punteggi. È stata organizzata una seconda fase di training per superare le differenze di valutazioni più evidenti e preparati nuovi animali ischemici con cui sostituire i video che presentavano errori. Il risultato ottenuto dall’interrater agreement del secondo trial è stato di ICC=0.64 (0.37 – 0.85) per i topi e ICC=0.69 (0.44 - 0.88) per i ratti, soddisfacendo quindi il criterio per iniziare la fase interventistica dello studio. La fase di armonizzazione rappresenta un nuovo ed originale approccio nella ricerca preclinica e dovrebbe rappresentare lo schema di lavoro di base per pianificare uno studio pRCT al fine di renderlo solido e predittivo.
In view of fostering transferability of pre-clinical data on the efficacy of remote ischemic conditioning (RIC) in acute ischemic stroke, we designed two multi-centre translational trials in mice and rats of both sexes. We defined to model ischaemic stroke by the transient occlusion of the middle cerebral artery (tMCAo). The improvement of sensorimotor deficits at 48h after tMCAo in RIC-treated animals was defined as the primary outcome. This work presents the harmonization phase relative to the evaluation of sensorimotor deficits by De Simoni neuroscore. Each centre performed different tMCAo durations - 30, 45, 60 min - allowing sufficient variability in the outcome. Animals were monitored post-surgery according to the ARRIVE and IMPROVE guidelines and data was registered into an electronic case report form on RedCap. All animals were video recorded during the neuroscore and the videos (n=11 per species) were distributed and evaluated blindly by raters at all centres. The interrater agreement of neuroscore was described using intraclass correlation coefficient (ICC), ranging between ICC=0 (equivalent to chance) and ICC=1 (perfect agreement), setting a target of ICC≥0.60 as satisfactory. We obtained moderate agreement for mice (ICC=0.50 [0.22-0.77]) and rats (ICC=0.49 [0.21-0.77]). Errors were identified in animal handling and test execution. We thus performed a second training followed by a new blind evaluation replacing the videos with poor experimental execution. The interrater agreement improved for mice (ICC=0.64 [0.37-0.85]) and rats (ICC=0.69 [0.44-0.88]). In conclusion, two dedicated training on the neuroscore allowed us to reach the agreement target for both species and thus next proceed with the interventional phase of the project.
9

Klimek, Martin. "Neuroinformatika a sdílení dat z lékařských zobrazovacích systémů." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218660.

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The presented master's thesis deals with the issue of storing and sharing data from medical imaging systems. This thesis, inter alia, consists of organizational and informatics aspects of medical imaging systems data in multicentric studies containing MRI brain images. This thesis also includes technical design of a web-based application for image data sharing including a web interface suitable for manipulation with the image data stored in a database.
10

Pavan, Tatiana Liliane Rossi. "Concentrações séricas das citocinas Interleucina-2 (IL-2), Interleucina-6 (IL-6), Interleucina-10 (IL-10), Fator de Necrose Tumoral Alfa (TNF-) e Proteína Quimiotática de Monócitos-1 (MCP-1) em cães com linfoma multicêntrico." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/10/10136/tde-20062016-153112/.

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Linfomas representam um grupo de neoplasias que tem em comum a origem em células linforreticulares, manifestando-se geralmente em tecidos linfóides. Em sua evolução há uma reação generalizada contra as alterações sistêmicas que comprometem a homeostase, conhecida como resposta de fase aguda. Citocinas são proteínas relacionadas à imunidade inata e adquirida que medeiam diversas funções e estão envolvidas na resposta inflamatória e são produzidas em resposta a vários estímulos. Foram objetivos desse estudo, verificar se existem diferenças no perfil das citocinas interleucina-2, interleucina-6, interleucina-10, MCP-1 e TNF-alfa nos animais com linfoma multicêntrico ao diagnóstico, quando comparados a um grupo controle e verificar se existe diferença entre os níveis apresentados no momento do diagnóstico e na 6ª semana, momento em que se avalia a remissão. Os grupos do estudo foram constituídos por 20 cães com linfoma (experimental) e 19 cães clinicamente normais (controle) sendo excluídos do estudo cães que apresentavam tratamento prévio e/ou doença concomitante. A quantificação das variáveis estudadas foi realizada utilizando-se kit comercial CCYTOMAG 90K (Milliplex®), sendo as mesmas determinadas no grupo controle uma única vez e no grupo experimental, quando do diagnóstico e na 6ª semana de tratamento. A análise estatística foi realizada através de teste não paramétrico de Mann-Whitney não pareado para o grupo controle e diagnóstico, bem como o diagnóstico e a 6ª semana de tratamento, enquanto que a análise de variância simples (ANOVA) não paramétrico Kruskal-Wallis foi aplicada na comparação dos três grupos (controle, ato do diagnóstico e 6ª semana de tratamento) para todas as citocinas. Foi observada diferença significante nos níveis de IL-10 entre o grupo controle e o experimental ao diagnóstico (p= 0,0033). Os valores do grupo linfoma ao diagnóstico foram elevados em relação ao controle, sem diferença significante entre os momentos do diagnóstico e 6ª semana. As IL-2 e IL-6 mostraram diferenças significantes entre o grupo controle e o grupo linfoma ao diagnóstico (p= 0,0037 e p=0,0017, respectivamente), mas os valores do controle apresentaram-se elevados em relação ao momento do diagnóstico e não houve diferença entre o diagnóstico e 6ª semana. As citocinas TNF-α e MCP-1 não apresentaram diferença significativa. Concluiu-se que os animais com linfoma no diagnóstico apresentaram níveis séricos mais elevados de IL-10, quando comparados ao diagnóstico e ao grupo controle e seus níveis mantiveram-se elevados na 6ª semana de tratamento. As concentrações de IL-2 e IL-6 estiveram mais elevadas no grupo controle quando comparadas aos animais do grupo experimental e as concentrações de TNF-α e de MCP-1 não apresentaram diferença significativa
Lymphomas belongs to a group of malignancies that have in common the origin in lymphoreticular cells, and is generally manifested in lymphoid tissues. In its evolution there is a generalized reaction against the systemic changes that compromise the homeostasis, known as acute phase response. Cytokines are proteins related to innate and acquired immunity which mediate several functions and are involved in inflammatory response and produced in response to several stimulant. This study was designed to verify if there are differences in the profile of cytokines interleukin-2, interleukin-6, interleukin-10, MCP-1 and TNF-alpha in dogs with multicentric lymphoma when compared to a control group and see if there is difference between the levels at the time of diagnosis and at the 6th week, when remission is achieve. The study group consisted of 20 dogs with lymphoma (experimental) and 19 clinically healthy dogs (control). We excluded patients who had previous treatments and/ or concomitant disease. For measurements of cytokines we use a commercial kits CCYTOMAG 90K (Milliplex®), the same being determined in the control group only once and in the experimental group at diagnosis and at 6 week of treatment. Statistical analysis was performed using nonparametric Mann-Whitney unpaired test for the control group and diagnosis, and the diagnosis and 6 week of treatment, while the simple analysis of variance (ANOVA) nonparametric Kruskal-Wallis test was applied when comparing the three groups (control, diagnosis and act 6th week of treatment) for all cytokines. There was a significant difference in IL-10 levels between the control group and the experimental diagnosis (p = 0.0033). The values of the lymphoma group at diagnosis were higher than the control, without significant difference between the time of diagnosis and 6th week. IL-2 and IL-6 showed significant differences between the control and lymphoma groups at diagnosis (p = 0.0037 and p = 0.0017, respectively), but the control had higher levels than the lymphoma group and there was no difference between diagnosis and 6th week. The TNF-α and MCP-1 cytokines showed no significant difference. It was concluded that animals with lymphoma had higher serum levels of IL-10 when compared to control and their levels remained high at 6 weeks of treatment. IL-2 and IL-6 concentrations were higher in the control group compared to lymphoma group and the concentrations of TNF-α and MCP-1 were not significantly different
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Книги з теми "Multicentric":

1

Dutta, Indranee. Abortion in Mizoram: A multicentric study. Guwahati: Omeo Kumar Das Institute of Social Change and Development, 2005.

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2

Salvatore, Sergio, Jaan Valsiner, and Alessandro Gennaro. Multicentric identities in a globalizing world. Charlotte, NC: IAP, Information Age Publishing, Inc., 2014.

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3

Sharma, V. P. Seroepidemiology of human malaria: A multicentric study. Delhi: Malaria Research Centre, ICMR, 1989.

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Duggal, Ravi. Abortion services in India: Report of a multicentric enquiry. [Mumbai]: Centre for Enquiry into Health and Allied Themes, 2004.

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5

Helmut, Platz, Fries Rudolf, Hudec Marcus, and German-Austrian-Swiss Association for Head and Neck Tumors., eds. Prognoses of oral cavity carcinomas: Results of a multicentric retrospective observational study. München: Hanser, 1986.

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6

S, Sriramachari, and Indian Council of Medical Research., eds. Indian childhood cirrhosis (ICC): A multicentric national collaborative study of ICMR (1983-1987). New Delhi: Indian Council of Medical Research, 2006.

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7

Gatti, Uberto. La delinquenza giovanile in Italia: I risultati di una ricerca multicentrica. Lecce: Pensa multimedia, 2010.

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Gatti, Uberto. La delinquenza giovanile in Italia: I risultati di una ricerca multicentrica. Lecce: Pensa multimedia, 2010.

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9

Armin, Schmidtke, ed. Suicidal behaviour in Europe: Results from the WHO/Euro multicentre study on suicidal behaviour. Cambridge, MA: Hogrefe & Huber, 2004.

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10

Tscherne, H. Beckenverletzungen: Ergebnisse einer prospektiven, multizentrischen Studie = Pelvic injuries : results of a prospective multicentre study. New York: Springer-Verlag, 1997.

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Частини книг з теми "Multicentric":

1

Patel, Nisha R., Michael L. Wong, Anthony E. Dragun, Stephan Mose, Bernadine R. Donahue, Jay S. Cooper, Filip T. Troicki, et al. "Multicentric Disease." In Encyclopedia of Radiation Oncology, 519. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_570.

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2

Crowe, David R. "Multicentric Reticulohistiocytosis." In Deadly Dermatologic Diseases, 123–27. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-31566-9_19.

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3

Picci, Piero. "Multicentric Osteosarcoma." In Atlas of Musculoskeletal Tumors and Tumorlike Lesions, 165–68. Cham: Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-01748-8_39.

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4

Rodolfi, Stefano, Adam Greenspan, Michael Klein, and Carlo Selmi. "Multicentric Reticulohistiocytosis." In Rare Diseases of the Immune System, 35–50. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-05002-2_4.

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Polizzotto, Mark N., Thomas S. Uldrick, and Robert Yarchoan. "Multicentric Castleman Disease." In Encyclopedia of AIDS, 1–11. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-9610-6_6-1.

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6

Miranda, Roberto N., Joseph D. Khoury, and L. Jeffrey Medeiros. "Multicentric Castleman Disease." In Atlas of Lymph Node Pathology, 111–13. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7959-8_27.

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Polizzotto, Mark N., Thomas S. Uldrick, and Robert Yarchoan. "Multicentric Castleman Disease." In Cancers in People with HIV and AIDS, 245–60. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0859-2_18.

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8

Tillborg, Adriana Di Lorenzo, and Patrick Schmidt. "Multicentric policy practice." In Music Schools in Changing Societies, 173–87. New York: Routledge, 2023. http://dx.doi.org/10.4324/9781003365808-18.

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9

Polizzotto, Mark N., Thomas S. Uldrick, and Robert Yarchoan. "Multicentric Castleman Disease." In Encyclopedia of AIDS, 1403–12. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7101-5_6.

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10

Winters, Zoe, and Adam Heetun. "Multifocal and Multicentric Disease." In Oncoplastic Breast Surgery, 70–73. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781315115146-16.

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Тези доповідей конференцій з теми "Multicentric":

1

Antonini, Svetlana, Darko Kolaric, Zeljko Herceg, Tomislav Kulis, Zeljko Ferencic, Jadranka Katancic, Danijela Tomic Storga, and Marko Banic. "Thermographic visualization of multicentric breast carcinoma." In 2015 57th International Symposium ELMAR. IEEE, 2015. http://dx.doi.org/10.1109/elmar.2015.7334484.

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2

Göðüþ, F., G. Kaymak Karataþ, M. Beyazova, and V. Sepici. "AB0215 Multicentric reticulohistiocytosis: a case report." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.736.

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3

Cruz, Andrey Oliveira da, and Bruna Kariny de Oliveira Pereira. "P4.09 Brazilian multicentric campaign on hiv/aids." In STI and HIV World Congress Abstracts, July 9–12 2017, Rio de Janeiro, Brazil. BMJ Publishing Group Ltd, 2017. http://dx.doi.org/10.1136/sextrans-2017-053264.506.

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4

Arfaoui, R., MA Ferjaoui, Y. Berrazega, S. Khedhri, K. Abdessamia, M. Malek, K. Neji, and H. Gmara. "EPV074/#427 Cervical cancer: multicentric epidemiological study." In IGCS 2021 Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/ijgc-2021-igcs.142.

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5

Hammami, S., S. Bouomrani, O. Berriche, and A. Barhoumi. "AB0808 Multicentric study of systemic scleroderma in tunisia." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.6247.

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6

Holmes, Jennifer L., and Robert Browning. "Multicentric Fibrohistiocytic Proliferation Presenting As Secondary Spontaneous Pneumothorax." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6866.

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Fukuyama, Lucas, Gabriel Perlmutter Lago, Fanny Alcira Reyes Neira, Bruna Malheiros de Macedo Soares, Camila Gusmão Vicente de Carvalho, Letícia Pletsch, Gabriela Tiemi Ochikubo, et al. "MULTICENTRIC RETICULOHISTIOCYTOSIS: A DIAGNOSIS RIGHT IN THE FRONT." In XL Congresso Brasileiro de Reumatologia. Sociedade Brasileiro de Reumatologia, 2023. http://dx.doi.org/10.47660/cbr.2023.1885.

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8

Nasser, Mouhamad, Yurdagül Uzunhan, Sandrine Hirschi, Stéphane Jouneau, François Lebargy, Aurélien Justet, Camille Taillé, et al. "Idiopathic chronic obliterative bronchiolitis: a multicentric retrospective cohort." In ERS International Congress 2021 abstracts. European Respiratory Society, 2021. http://dx.doi.org/10.1183/13993003.congress-2021.oa4236.

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9

Maselli, R., L. Da Rio, M. Manno, P. Soriani, C. Fabbri, M. Sbrancia, C. Binda, et al. "Purastat Multicentric Registry: Preliminary results on the Italian Experience." In ESGE Days 2023. Georg Thieme Verlag KG, 2023. http://dx.doi.org/10.1055/s-0043-1765788.

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10

Starič, Jože, Geč Veren, Rok Marzel, and Jožica Ježek. "Sporadic leukosis in cattle." In Zbornik radova 26. medunarodni kongres Mediteranske federacije za zdravlje i produkciju preživara - FeMeSPRum. Poljoprivredni fakultet Novi Sad, 2024. http://dx.doi.org/10.5937/femesprumns24035s.

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Sporadic bovine leukosis (SBL) is a rare neoplastic disease in cattle. It represents a unique challenge for veterinary medicine due to its sporadic occurrence, peculiar clinical presentation and unclear etiology. SBL manifests in four forms: juvenile lymphosarcoma, adult multicentric leukosis, thymic lymphosarcoma and cutaneous lymphosarcoma. In contrast to enzootic bovine leukosis, which is caused by the bovine leukemia virus (BLV), there is no viral link in sporadic cases. They are thought to be caused by multifactorial interactions between genetic predisposition and environmental factors (e.g. carcinogens or other triggers). The diseases are not contagious. The aim of this paper is to review the current knowledge of SBL, focusing on the clinical presentation, diagnostic challenges and potential risk factors. Although sporadic leukosis accounts for a smaller proportion of leukosis cases in cattle compared to BLV-induced leukosis, the impact on affected individuals is severe. SBL must be differentiated from BLV-induced leukosis (absence of BLV antibodies in the blood and absence of BLV in the tissue), which is a reportable disease in the European Union. SBL usually affects younger cattle, but adult animals can also be affected. Adult multicentric leukosis clinically resembles enzootic bovine leukosis with multicentric lymphoproliferative foci and lymphadenopathy, but the affected animals are negative for BLV antibodies. The diseases are progressive and lead to the death of the animals. Diagnostic confirmation of SBL often requires a combination of histopathologic examination, immunohistochemistry and molecular analyses to differentiate it from other neoplastic diseases in cattle. Risk factors such as exposure to certain environmental toxins or genetic susceptibility are thought to play a role in the development of sporadic leukosis. Further research efforts are needed to elucidate the mechanisms underlying the development of SBL and to develop effective prevention and control strategies to control this sporadic but usually lethal disease in cattle population.

Звіти організацій з теми "Multicentric":

1

District level baseline survey of family planning program in Uttar Pradesh: Pithoragarh. Population Council, 1995. http://dx.doi.org/10.31899/rh1995.1012.

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In 1992, the Ministry of Health and Family Welfare and the United States Agency for International Development, New Delhi, began the Innovations in Family Planning Services Project (IFPS) under the management of the State Innovation in Family Planning Services Agency (SIFPSA), Lucknow. The goal was to reduce the fertility rate in Uttar Pradesh by expanding and improving family planning (FP) services. To achieve this, the IFPS project will support service innovations in the public sector and nongovernmental sectors and through contraceptive social marketing mechanisms. The Baseline Survey in Uttar Pradesh (BSUP) is being undertaken as one important component of the IFPS project. The BSUP is designed to provide information on fertility, FP, and maternal and child health care that will be helpful in monitoring and evaluating population and family welfare policies and programs. SIFPSA has designated the Population Council as the nodal organization responsible for providing technical guidance for the survey. The responsibility of conducting this multicentric survey in the district of Pithoragarh was given to the Indian Institute of Health Management Research, Jaipur.

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