Готові списки джерел за темами / Microfluidic method

Добірка наукової літератури з теми "Microfluidic method"

Автор: Grafiati
Опубліковано: 7 липня 2024

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Статті в журналах з теми "Microfluidic method":

1

Liu, Jingji, Boyang Zhang, Yajun Zhang, and Yiqiang Fan. "Fluid control with hydrophobic pillars in paper-based microfluidics." Journal of Micromechanics and Microengineering 31, no. 12 (November 16, 2021): 127002. http://dx.doi.org/10.1088/1361-6439/ac35c9.

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Abstract Paper-based microfluidics has been widely used in chemical and medical analysis applications. In the conventional paper-based microfluidic approach, fluid is propagating inside the porous structure, and the flow direction of the fluid propagation is usually controlled with the pre-defined hydrophobic barrier (e.g. wax). However, the fluid propagation velocity inside the paper-based microfluidic devices largely depends on the material properties of paper and fluid, the relative control method is rarely reported. In this study, a fluid propagation velocity control method is proposed for paper-based microfluidics: hydrophobic pillar arrays with different configurations were deposited in the microchannels in paper-based microfluidics for flow speed control, the result indicates the deposited hydrophobic pillar arrays can effectively slow down the fluid propagation at different levels and can be used to passively control the fluid propagation inside microchannels for paper-based microfluidics. For the demonstration of the proposed fluid control methods, a paper-based microfluidic device for nitrite test in water was also fabricated. The proposed fluid control method for paper-based microfluidics may have significant importance for applications that involve sequenced reactions and more actuate fluid manipulation.
2

LI, CHIYU, WANG LI, CHUNYANG GENG, HAIJUN REN, XIAOHUI YU, and BO LIU. "MICROFLUIDIC CHIP FOR CANCER CELL DETECTION AND DIAGNOSIS." Journal of Mechanics in Medicine and Biology 18, no. 01 (February 2018): 1830001. http://dx.doi.org/10.1142/s0219519418300016.

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Since cancer becomes the most deadly disease to our health, research on early detection on cancer cells is necessary for clinical treatment. The combination of microfluidic device with cell biology has shown a unique method for cancer cell research. In the present review, recent development on microfluidic chip for cancer cell detection and diagnosis will be addressed. Some typical microfluidic chips focussed on cancer cells and their advantages for different kinds of cancer cell detection and diagnosis will be listed, and the cell capture methods within the microfluidics will be simultaneously mentioned. Then the potential direction of microfluidic chip on cancer cell detection and diagnosis in the future is also discussed.
3

Switalla, Ander, Lael Wentland, and Elain Fu. "3D printing-based microfluidic devices in fabric." Journal of Micromechanics and Microengineering 33, no. 2 (January 19, 2023): 027001. http://dx.doi.org/10.1088/1361-6439/acaff1.

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Abstract Fabric-based microfluidics is a growing sub-field of porous materials-based microfluidics. 3D printing has been demonstrated as a useful fabrication method for open channel microfluidic devices, and also in the context of porous substates such as cellulose. In the current report, we describe a straightforward method for 3D printing fabric-based microfluidic devices. We demonstrate the ability to create both full and partial barriers in fabric, characterizing minimum channel and barrier widths, as well as reproducibility of the method using the metric of flow time repeatability through the channels. We discuss considerations specific to 3D printing in fabric including fabric anisotropy, stretching, and nonuniformity. Further, we highlight our fabrication method via the implementation of a colorimetric urea assay.
4

BAI, BOFENG, ZHENGYUAN LUO, TIANJIAN LU, and FENG XU. "NUMERICAL SIMULATION OF CELL ADHESION AND DETACHMENT IN MICROFLUIDICS." Journal of Mechanics in Medicine and Biology 13, no. 01 (January 10, 2013): 1350002. http://dx.doi.org/10.1142/s0219519413500024.

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Inspired by the complex biophysical processes of cell adhesion and detachment under blood flow in vivo, numerous novel microfluidic devices have been developed to manipulate, capture, and separate bio-particles for various applications, such as cell analysis and cell enumeration. However, the underlying physical mechanisms are yet unclear, which has limited the further development of microfluidic devices and point-of-care (POC) systems. Mathematical modeling is an enabling tool to study the physical mechanisms of biological processes for its relative simplicity, low cost, and high efficiency. Recent development in computation technology for multiphase flow simulation enables the theoretical study of the complex flow processes of cell adhesion and detachment in microfluidics. Various mathematical methods (e.g., front tracking method, level set method, volume of fluid (VOF) method, fluid–solid interaction method, and particulate modeling method) have been developed to investigate the effects of cell properties (i.e., cell membrane, cytoplasma, and nucleus), flow conditions, and microchannel structures on cell adhesion and detachment in microfluidic channels. In this paper, with focus on our own simulation results, we review these methods and compare their advantages and disadvantages for cell adhesion/detachment modeling. The mathematical approaches discussed here would allow us to study microfluidics for cell capture and separation, and to develop more effective POC devices for disease diagnostics.
5

Xi, Wang, Fang Kong, Joo Chuan Yeo, Longteng Yu, Surabhi Sonam, Ming Dao, Xiaobo Gong, and Chwee Teck Lim. "Soft tubular microfluidics for 2D and 3D applications." Proceedings of the National Academy of Sciences 114, no. 40 (September 18, 2017): 10590–95. http://dx.doi.org/10.1073/pnas.1712195114.

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Microfluidics has been the key component for many applications, including biomedical devices, chemical processors, microactuators, and even wearable devices. This technology relies on soft lithography fabrication which requires cleanroom facilities. Although popular, this method is expensive and labor-intensive. Furthermore, current conventional microfluidic chips precludes reconfiguration, making reiterations in design very time-consuming and costly. To address these intrinsic drawbacks of microfabrication, we present an alternative solution for the rapid prototyping of microfluidic elements such as microtubes, valves, and pumps. In addition, we demonstrate how microtubes with channels of various lengths and cross-sections can be attached modularly into 2D and 3D microfluidic systems for functional applications. We introduce a facile method of fabricating elastomeric microtubes as the basic building blocks for microfluidic devices. These microtubes are transparent, biocompatible, highly deformable, and customizable to various sizes and cross-sectional geometries. By configuring the microtubes into deterministic geometry, we enable rapid, low-cost formation of microfluidic assemblies without compromising their precision and functionality. We demonstrate configurable 2D and 3D microfluidic systems for applications in different domains. These include microparticle sorting, microdroplet generation, biocatalytic micromotor, triboelectric sensor, and even wearable sensing. Our approach, termed soft tubular microfluidics, provides a simple, cheaper, and faster solution for users lacking proficiency and access to cleanroom facilities to design and rapidly construct microfluidic devices for their various applications and needs.
6

Yip, Hon Ming, John C. S. Li, Kai Xie, Xin Cui, Agrim Prasad, Qiannan Gao, Chi Chiu Leung, and Raymond H. W. Lam. "Automated Long-Term Monitoring of Parallel Microfluidic Operations Applying a Machine Vision-Assisted Positioning Method." Scientific World Journal 2014 (2014): 1–14. http://dx.doi.org/10.1155/2014/608184.

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As microfluidics has been applied extensively in many cell and biochemical applications, monitoring the related processes is an important requirement. In this work, we design and fabricate a high-throughput microfluidic device which contains 32 microchambers to perform automated parallel microfluidic operations and monitoring on an automated stage of a microscope. Images are captured at multiple spots on the device during the operations for monitoring samples in microchambers in parallel; yet the device positions may vary at different time points throughout operations as the device moves back and forth on a motorized microscopic stage. Here, we report an image-based positioning strategy to realign the chamber position before every recording of microscopic image. We fabricate alignment marks at defined locations next to the chambers in the microfluidic device as reference positions. We also develop image processing algorithms to recognize the chamber positions in real-time, followed by realigning the chambers to their preset positions in the captured images. We perform experiments to validate and characterize the device functionality and the automated realignment operation. Together, this microfluidic realignment strategy can be a platform technology to achieve precise positioning of multiple chambers for general microfluidic applications requiring long-term parallel monitoring of cell and biochemical activities.
7

Hamad, Eyad M., Ahmed Albagdady, Samer Al-Gharabli, Hamza Alkhadire, Yousef Alnaser, Hakim Shadid, Ahmed Abdo, Andreas Dietzel, and Ala’aldeen Al-Halhouli. "Optimizing Rapid Prototype Development Through Femtosecond Laser Ablation and Finite Element Method Simulation for Enhanced Separation in Microfluidics." Journal of Nanofluids 12, no. 7 (October 1, 2023): 1868–79. http://dx.doi.org/10.1166/jon.2023.2102.

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In recent years, microfluidic systems have emerged as promising tools for blood separation and analysis. However, conventional methods for prototyping microfluidic systems can be slow and expensive. In this study, we present a novel approach to rapid prototyping that combines femtosecond laser ablation and finite element method (FEM) simulation. The optimization of the prototyping process was achieved through systematic characterization of the laser ablation process and the application of FEM simulation to predict the flow behavior of the microfluidic devices. Using a dean-coupled inertial flow device (DCIFD) that comprises one channel bend and three outlets side-channels. DCIF is a phenomenon that occurs in curved microfluidic channels and is considered by the existence of inconsequential flow patterns perpendicular to the main flow direction. The DCIF can enhance the separation efficiency in microfluidic devices by inducing lateral migration of particles or cells towards specific locations along the channel. This lateral migration can be controlled by adjusting the curvature and dimensions of the channel, as well as the flow rate and properties of the fluid. Overall, DCIF can provide a valuable means of achieving efficient and high-throughput separation of particles or cells in microfluidic devices. Therefore, various microfluidics designs that contain different outlet channels were studied in this research to improve blood plasma separation efficiency. Results from imitated blood flow experiments showed positive results for fluid flow and particle separation. The study also found that incorporating three various channel widths is the key to achieving efficient plasma separation, indicating that this result could serve as a guideline for future microfluidics geometry specifications in the field of blood plasma separation. According to the FEM simulation, the highest separation percentage for both microparticle sizes was obtained by incorporating a variable outlet channel width into the same microfluidic device. The FEM simulation revealed that around 95% of the larger microparticles separated while 98% of the smaller microparticles separated. This is consistent with the imitated blood separation results, which showed that 91% of the larger microparticles separated and around 93% of the smaller microparticles were separated. Overall, our results demonstrate that the combination of femtosecond laser ablation and FEM simulation significantly improved the prototyping speed and efficiency while maintaining high blood separation performance.
8

Khodamoradi, Maedeh, Saeed Rafizadeh Tafti, Seyed Ali Mousavi Shaegh, Behrouz Aflatoonian, Mostafa Azimzadeh, and Patricia Khashayar. "Recent Microfluidic Innovations for Sperm Sorting." Chemosensors 9, no. 6 (June 1, 2021): 126. http://dx.doi.org/10.3390/chemosensors9060126.

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Sperm selection is a clinical need for guided fertilization in men with low-quality semen. In this regard, microfluidics can provide an enabling platform for the precise manipulation and separation of high-quality sperm cells through applying various stimuli, including chemical agents, mechanical forces, and thermal gradients. In addition, microfluidic platforms can help to guide sperms and oocytes for controlled in vitro fertilization or sperm sorting using both passive and active methods. Herein, we present a detailed review of the use of various microfluidic methods for sorting and categorizing sperms for different applications. The advantages and disadvantages of each method are further discussed and future perspectives in the field are given.
9

Soitu, Cristian, Alexander Feuerborn, Cyril Deroy, Alfonso A. Castrejón-Pita, Peter R. Cook, and Edmond J. Walsh. "Raising fluid walls around living cells." Science Advances 5, no. 6 (June 2019): eaav8002. http://dx.doi.org/10.1126/sciadv.aav8002.

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An effective transformation of the cell culture dishes that biologists use every day into microfluidic devices would open many avenues for miniaturizing cell-based workflows. In this article, we report a simple method for creating microfluidic arrangements around cells already growing on the surface of standard petri dishes, using the interface between immiscible fluids as a “building material.” Conventional dishes are repurposed into sophisticated microfluidic devices by reshaping, on demand, the fluid structures around living cells. Moreover, these microfluidic arrangements can be further reconfigured during experiments, which is impossible with most existing microfluidic platforms. The method is demonstrated using workflows involving cell cloning, the selection of a particular clone from among others in a dish, drug treatments, and wound healing. The versatility of the approach and its biologically friendly aspects may hasten uptake by biologists of microfluidics, so the technology finally fulfills its potential.
10

Bogseth, Amanda, Jian Zhou, and Ian Papautsky. "Evaluation of Performance and Tunability of a Co-Flow Inertial Microfluidic Device." Micromachines 11, no. 3 (March 10, 2020): 287. http://dx.doi.org/10.3390/mi11030287.

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Microfluidics has gained a lot of attention for biological sample separation and purification methods over recent years. From many active and passive microfluidic techniques, inertial microfluidics offers a simple and efficient method to demonstrate various biological applications. One prevalent limitation of this method is its lack of tunability for different applications once the microfluidic devices are fabricated. In this work, we develop and characterize a co-flow inertial microfluidic device that is tunable in multiple ways for adaptation to different application requirements. In particular, flow rate, flow rate ratio and output resistance ratio are systematically evaluated for flexibility of the cutoff size of the device and modification of the separation performance post-fabrication. Typically, a mixture of single size particles is used to determine cutoff sizes for the outlets, yet this fails to provide accurate prediction for efficiency and purity for a more complex biological sample. Thus, we use particles with continuous size distribution (2–32 μm) for separation demonstration under conditions of various flow rates, flow rate ratios and resistance ratios. We also use A549 cancer cell line with continuous size distribution (12–27 μm) as an added demonstration. Our results indicate inertial microfluidic devices possess the tunability that offers multiple ways to improve device performance for adaptation to different applications even after the devices are prototyped.
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Статті в журналах Дисертації Книги

Дисертації з теми "Microfluidic method":

1

Nguyen, Khanh H. (Khanh Huy). "Hot embossing as a method for rapid prototyping microfluidic devices." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/85789.

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Thesis: M. Eng. in Manufacturing, Massachusetts Institute of Technology, Department of Mechanical Engineering, 2013.
Title as it appears in Degrees awarded program, September 17, 2003: Design and analysis of a hot embossing machine and the effects of toolware and accuracy of resin replication of high aspect ratio microfluidic features Cataloged from PDF version of thesis.
Includes bibliographical references (pages 132-135).
Hot embossing is a growing technology proven to be capable of reproducing micro-scale features on thermoplastics and can be an effective process for rapid prototyping microfluidic devices with high aspect ratio micro features. Advantages of this manufacturing process can include tooling flexibility, fast production time, low capital cost and a vast selection of production materials. A greater understanding on the micro feature transferring capabilities and use limits of tools are needed so that hot embossing may advance to becoming a practical technique for producing microfluidic parts. This work focuses on both the design and analysis of a hot embossing system and a brass tool to replicate an existing functional high aspect ratio micro feature onto Polymethyl methacrylate (PMMA). The aspect ratio of features ranged from 10:1 to 4,000:1. Optimal embossing parameters used a pressure of 3.5kN, hold time of 12 minutes, tool temperatures of 140°C and substrate temperature of 130°C to produce parts that filled shoulder heights and widths up to 97% and 90%, respectively. The wearing of features on the metal tool were also characterized for purposes of understanding the limits on tool use and was found that a maximum range of +/-3[mu]m in dimensional change existed. Gains in tool dimensions were then mainly attributed to the deposition of embossed materials onto the tool. The study further determined a method for creating usable resin tool copies that exhibited a replication accuracy of less than 2%, on average, for micron size features.
by Khanh H. Nguyen.
M. Eng. in Manufacturing
2

Lustrino, Michelle E. (Michelle Elizabeth). "The development of an innovative bonding method for microfluidic applications." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/67622.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2011.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 145-149).
The field of microfluidics has powerful applications in low-cost healthcare diagnostics, DNA analysis, and fuel cells, among others. As the field moves towards commercialization, the ability to robustly manufacture these devices at low cost is becoming more important. One of the many challenges in microfluidic manufacturing is the reliable sealing of the microfluidic chips once the channels have been generated. This work was an investigation of innovative ways to robustly heat the substrate-cover plate interface of a microfluidic device for the purpose of bonding and sealing the microfluidic channels. An extensive literature review revealed the benefits of interfacial heating, and both simulations and experimental investigations were used to evaluate a few different methods. Ultimately, a unique method was established that uses light to provide both the bonding energy and the illumination for an in-process vision system for real-time viewing and control of the bonding process. The process results in the generation of a homogenous and optically clear bond, and preliminary tests show that when properly controlled, a bond with minimal microchannel deformation can be created.
by Michelle E. Lustrino.
S.M.
3

Wu, Jun, and 吴隽. "Drug delivery devices fabricated by microfluidic method and their applications in long-term antimicrobial therapy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/198816.

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Controlled drug delivery devices provide numerous advantages such as reduced side effects, higher therapeutic efficiency and improved patient compliance. Biodegradable polymer has become the most important material for controlled drug delivery device because of the excellent biocompatibility and tunable physicochemical properties. Biodegradable polymeric drug delivery devices are usually processed into various types of micro-particles due to the ease of fabrication and administration. However, controlling the drug release kinetics of these microparticles is still a challenge. One important reason is that drug release kinetics is significantly influenced by the microstructure of drug delivery devices, which is difficult to control. 　Microfluidic method is a group of technologies involved in the manipulation of fluids using channels in the scale of micrometers. Microfluidic method is particularly useful in controlling the structure of micro-droplets and generating homogeneous droplets. Therefore, microfluidics suggests great potential in controlling microstructures of drug delivery devices and drug release kinetics. 　In this study, biodegradable polymer based controlled drug delivery devices were fabricated using microfluidic method. Various types of microstructures were developed such as microspheres, core-shell microspheres, hollow microspheres and hydrogel microspheres. The results showed that microstructures were well controlled by fluid flow rates and geometries of capillary microfluidic devices. Both hydrophobic and hydrophilic drugs could be delivered by choosing drug delivery devices with suitable microstructures. 　Drug release kinetics of biodegradable polymeric microspheres has been studies a lot, yet complete understanding is still to be achieved. The diameter is an important factor which contributes to the drug release kinetics. However, the influence of diameter has not been systemically studied because monodisperse microspheres are difficult to obtain. Using microfluidic method, monodisperse PLGA microspheres with different diameters were fabricated to study the influence of diameter on drug release kinetics. It was found that diameter only influence the duration of the first phase (lag phase) in drug release process and smaller microspheres exhibited shorter lag phase. The relatively faster expansion of smaller microspheres was found to be responsible for the size effect by monitoring physicochemical changes during drug release. 　Rifampicin, a broad-spectrum antibiotic, was encapsulated by PLGA microspheres and PLGA-alginate core-shell microspheres. The long-term antimicrobial effects of drug loaded microspheres were investigated by drug release test and antimicrobial test against Staphylococcus aureus. The results showed that drug delivery devices could provide antimicrobial effect for more than one month. These drug delivery devices show potential in applications of controlled drug delivery and long-term antimicrobial therapy. 　In conclusion, drug delivery devices with different microstructures were fabricated using microfluidic method. The diameter of PLGA microspheres only influence the first phase of drug release profile (lag phase) and smaller microspheres exhibited shorter lag phase. The size effect is due to the relatively faster expansion rate of smaller microspheres. Rifampicin loaded PLGA microspheres and PLGA-alginate core-shell microspheres could provide sustained release of rifampicin for more than one month. The released rifampicin was able to inhibit the growth of Staphylococcus aureus. The controlled drug delivery devices presented showed great potential in long-term antimicrobial applications.
published_or_final_version
Orthopaedics and Traumatology
Doctoral
Doctor of Philosophy
4

PENNELLA, FRANCESCO. "Analysis of microscale flows in tissue engineering systems and microfluidic devices." Doctoral thesis, Politecnico di Torino, 2013. http://hdl.handle.net/11583/2514479.

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The doctoral research summarized in this thesis has focused on the study of microflows in Tissue Engineering (TE) scaffolds and microdevices. The thesis is organized in two parts. In the first part, the properties influencing mass transport through scaffold are investigated both experimentally and in silico. In detail: (1) an acoustic measurement system suitable for the evaluation of TE porous scaffolds and based on a single (pressure) transducer is developed; (2) realistic models of irregular porous scaffolds were reconstructed from micro-CT images and fluid transport through them is simulated by applying the Lattice Boltzmann method. In the second part, the issue of mixing of species in microdevices is investigated in depth and a novel low-cost passive microfluidic mixer design is proposed and its performance evaluated both in silico and in vitro. PART I: The performance of porous scaffold for tissue engineering (TE) applications are generally evaluated in terms of porosity, pore size and distribution, and pore tortuosity. However these descriptors are often confounding when they are applied to characterize the mass transport within porous scaffolds. On the contrary, permeability is a more effective parameter in (1) estimating mass and species transport through the scaffold and (2) describing its topological features. Therefore, this first part has focused on the study of TE porous scaffold permeability and on its dependence on the microscopic features of the scaffold. Firstly, an overview of methods applied to evaluate TE scaffold permeability is provided, with an emphasis on both experimental and computational approaches. In detail, after a discussion on the most relevant scaffolds features to be considered in the evaluation of the permeability, the presentation of the theoretical background and the introduction of semi-empirical models relating scaffolds features to permeability, the most widely applied experimental setup for the direct measurement of tissue engineered scaffold permeability are presented. Then, the focus is put on the application of computational methods, useful to verify and compare the experimental measurements of permeability, and to integrate experimental data with a more quantitative analysis which is very effective in supporting the design process of TE porous scaffolds. In conclusion, limitations of the methods and future challenges are pointed out. Successively, an acoustic permeability measurement system to quantify the inter-pore connectivity structure of tissue-engineering scaffolds by using a single (pressure) transducer is presented. The proposed method has been developed keeping in mind the limitations of the permeability measurement system in TE field. Technically, this system uses a slow alternating airflow as a fluid medium and allows at the same time a simple and accurate measurement procedure. The intrinsic permeability has been determined in the linear Darcy’s region, and deviation from linearity due to inertial losses has been also quantified. The structural parameters of a scaffold, such as effective porosity, tortuosity and effective length of cylindrical pores, have been estimated using the modified Ergun’s equation. From this relation, it is possible to achieve a well-defined range of data and associated uncertainties for characterizing the structure/architecture of tissue-engineering scaffolds. This quantitative analysis is of paramount importance in tissue engineering, where scaffold topological features are strongly related to their biological performance. In the last investigation of this part, the permeability of three bioactive glass/polymer composite scaffolds for bone tissue regeneration is evaluated. Structural features such as porosity, specific surface area and tortuosity, and lacunarity have been measured as well. Concerning lacunarity analysis, results confirmed its potential in providing insights into (i) self-similarity, (ii) random structure at some scale (i.e. heterogeneity) and (iii) Representative Elementary Volume (REV) identification. Permeability is evaluated both experimentally and computationally using the novel acoustic permeability system and Lattice Boltzmann Method (LBM), respectively. The advantage of LBM approach is due to their geometric versatility in simulating flows in irregular porous media. Results of the LBM models are in good agreement with the experimental results, even if the permeability values estimated in silico overestimate experimental data. This discrepancy is due to the influence of grid resolution and sample size on permeability calculations. In addition, the lower permeability values obtained in this study than the permeability data of different bone tissue reported in literature confirms the need to optimize the design of these scaffolds in terms of mass transport. PART II: Microfluidic deals with the control and manipulation of fluids at the microscale. A typical microfluidic platform is characterized by several components. One of the most important is the micromixer. Mixing of species is often critical to be achieved, since microfluidics is characterized mainly by very low Reynolds flows, and cannot take advantage of turbulence in order to enhance mixing. A good understanding of the dynamic of mixing becomes crucial to i) improve the effectiveness of and ii) speed up chemical reactions. In order to enhance mixing, several techniques have been developed. In general, mixing strategies can be classified as either active or passive, according to the operational mechanism. Active mixers employ external forces in order to perform mixing, so that actuation system must be embedded into the microchips. On the contrary, passive mixers avoid resorting to external electrical or mechanical sources by exploiting characteristics of specific flow fields in microchannel geometries to mix species, offering the advantage to be easy to be produced and integrated. The aim of this investigation was to develop a new low-cost passive microfluidic mixer design. First, a survey of the passive micromixing solutions currently adopted is provided. In detail, the most widely used microchannel geometries and the metrics used to quantify mixing effectiveness in microfluidic applications has been discussed. Then, a new low-cost passive microfluidic mixer design, based on a replication of identical mixing units composed of microchannels with variable curvature (clothoid) geometry, is shown. The micromixer presents a compact and modular architecture that can be easily fabricated using a simple and reliable fabrication process. The particular clothoid-based geometry enhances the mixing by inducing transversal secondary flows and recirculation effects. The role of the relevant fluid mechanics mechanisms promoting the mixing in this geometry have been analysed using computational fluid dynamics (CFD) for Reynolds numbers ranging from 1 to 110. A measure of mixing potency has been quantitatively evaluated by calculating mixing efficiency, while a measure of particle dispersion has been assessed through the lacunarity index. The results showed that the secondary flow arrangement and recirculation effects are able to provide a mixing efficiency equal to 80% at Reynolds number above 70. In addition, the analysis of particles distribution promotes the lacunarity as powerful tool to quantify the dispersion of fluid particles and, in turn, the overall mixing. On fabricated micromixer prototypes the microscopic-Laser-Induced-Fluorescence (µLIF) technique has been applied to characterize mixing. The experimental results confirmed the mixing potency of the microdevice. In conclusion, the proposed design (i) assures a good mixing efficiency (i.e. comparable, if not superior, to other passive micromixer, (ii) is easy to fabricate (i.e. single layer microfluidic devices) and (iii) is easy to integrate (i.e. high modularity).
5

Jeon, Jessie Sungyun. "3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/61871.

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Анотація:
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 48-51).
A microfluidic system has been developed for studying the factors inducing different responses of cells in vascular system using a three-dimensional microenvironment. The devices have been transferred from PDMS to a platform in cyclic olefin copolymer (COC) which has advantages in terms of hydrophobicity, production by the more commercially-viable hot embossing technique, and amenability to surface treatments. Here the fabrication process is described and the new systems are characterized. Surface wettability, bond strength between the system body and a covering plastic film, and cell viability data are presented and compared to systems fabricated in PDMS.
by Jessie Sungyun Jeon.
S.M.
6

Winer, Michael Hubert. "A three-dimensional (3D) defocusing-based particle tracking method and applications to inertial focusing in microfluidic devices." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50194.

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Three-dimensional analysis of particles in flows within microfluidic devices is a necessary technique in the majority of current microfluidics research. One method that allows for accurate determination of particle positions in channels is defocusing-based optical detection. This thesis investigates the use of the defocusing method for particles ranging in size from 2-18 μm without the use of a three-hole aperture. Using a calibration-based analysis motivated by previous work, we were able to relate the particle position in space to its apparent size in an image. This defocusing method was then employed in several studies in order to validate its effectiveness in a wide range of particle/flow profiles. An initial study of gravitational effects on particles in low Reynolds number flows was conducted, showing that the method is accurate for particles with sizes equal to or greater than approximately 2 μm. We also found that the resolution of particle position accuracy was within 1 μm of expected theoretical results. Further studies were conducted in inertial focusing conditions, where viscous drag and inertial lift forces balance to create unique particle focusing positions in straight channels. Steady-state inertial studies in both rectangular and cylindrical channel geometries showed focusing of particles to positions similar to previous work, further verifying the defocusing method. A new regime of inertial focusing, coined transient flow, was also investigated with the use of the 3D defocusing method. This study established new regimes of particle focusing due to the effects of a transient flow on inertial forces. Within the transient study, the effects of fluid and particle density on particle focusing positions were also investigated. Finally, we provide recommendations for future work on the defocusing method and transient flows, including potential applications.
Applied Science, Faculty of
Graduate
7

Othman, Rahimah. "Production of functional pharmaceutical nano/micro-particles by solvent displacement method using advanced micro-engineered dispersion devices." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/22905.

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The rapid advancement of drug delivery systems (DDS) has raised the possibility of using functional engineered nano/micro-particles as drug carriers for the administration of active pharmaceutical ingredients (APIs) to the affected area. The major goals in designing these functional particles are to control the particle size, the surface properties and the pharmacologically active agents release in order to achieve the site-specification of the drug at the therapeutically optimal rate and dose regimen. Two different equipment (i.e. glass capillary microfluidic device and micro-engineered membrane dispersion cell) were utilised in this study for the formation of functional nano/micro-particles by antisolvent precipitation method. This method is based on micromixing/direct precipitation of two miscible liquids, which appear as a straightforward method, rapid and easy to perform, does not require high stirring rates, sonication, elevated temperatures, surfactants and Class 1 solvents can be avoided. Theoretical selection of a good solvent and physicochemical interaction between solvent-water-polymer with the aid of Bagley s two-dimensional graph were successfully elucidated the nature of anti-solvent precipitation method for the formation of desired properties of functional pharmaceutical nano/micro-engineered particles. For the glass capillary microfluidic experiment, the organic phase (a mixture of polymer and tetrahydrofuran/acetone) was injected through the inner glass capillary with a tapered cross section culminated in a narrow orifice. The size of nanoparticles was precisely controlled by controlling phase flow rates, orifice size and flow configuration (two- phase co-flow or counter-current flow focusing). The locations at which the nanoparticles would form were determined by using the solubility criteria of the polymer and the concentration profiles found by numerical modelling. This valuable results appeared as the first computational and experimental study dealing with the formation of polylactide (PLA) and poly(ε-caprolactone) (PCL) nanoparticles by nanoprecipitation in a co-flow glass capillary device. The optimum formulations and parameters interactions involved in the preparation of paracetamol encapsulated nanoparticles (PCM-PCL NPs) using a co-flow microfluidic device was successfully simulated using a 25-full factorial design for five different parameters (i.e. PCL concentration, orifice size, flow rate ratios, surfactant concentration and paracetamol amount) with encapsulation efficiency and drug loading percentage as the responses. PCM-loaded composite NPs composed of a biodegradable poly(D,L-lactide) (PLA) polymer matrix filled with organically modified montmorillonite (MMT) nanoparticles were also successfully formulated by antisolvent nanoprecipitation in a microfluidic co-flow glass capillary device. The incorporation of MMT in the polymer matrix improved the drug encapsulation efficiency and drug loading, and extended the rate of drug release in simulated intestinal fluid (pH 7.4). The encapsulation of MMT and PCM in the NPs were well verified using transmission electron microscopy (TEM), energy dispersive x-ray spectroscopy (EDS), x-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR). PCL drug-carrier nanoparticles were also produced by rapid membrane micromixing combined with nanoprecipitation in a stirred cell employing novel membrane dispersion. The size of the NPs was precisely controlled by changing the aqueous-to-organic volumetric ratio, stirring rate, transmembrane flux, the polymer content in the organic phase, membrane type and pore morphologies. The particle size decreased by increasing the stirring rate and the aqueous-to-organic volumetric ratio, and by decreasing the polymer concentration in the aqueous phase and the transmembrane flux. The existence of the shear stress peak within a transitional radius and a rapid decline of the shear stress away from the membrane surface were revealed by numerical modelling. Further investigation on the PCL nanoparticles loaded immunosuppressive rapamycin (RAPA) drug were successfully synthesised by anti-solvent nanoprecipitation method using stainless steel (SS) ringed micro-engineered membrane. Less than 10 μm size of monohydrate piroxicam (PRX) micro-crystals also was successfully formed with the application of anti-solvent precipitation method combined with membrane dispersion cell that has been utilised in the formation of functional engineered nanoparticles. This study is believed to be a new insight into the development of integrated membrane crystallisation system.
8

Murali, Divya. "A Sampling Method for the Reduction of Power Consumption in Battery Operated UHF Receivers." University of Akron / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1220634056.

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9

Duford, David. "Instrumentation, fabrication techniques and method development for sample introduction, preparation and extraction on centrifugal microfluidic devices in motion." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110441.

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A growing number of pollutants are being shown to have a large environmental and health impact resulting in stricter legislative limits. Increased environmental monitoring is forcing analytical chemists to consider automating and miniaturizing current standard methods. Instrumentation and sample handling techniques for centrifugal microfluidic devices in motion have been developed with the objective of integrating multi-step reactions into a single device for the analysis of environmental solid samples.In order to study and optimize centrifugal microfluidic devices in motion, motorized stages integrating a camera, strobe and a variety of other peripheral components were developed. These allowed precise control of the devices throughout the methods' spin sequences and simultaneous acquisition of a series of stop action photographs of the devices.Non-contact methodologies for sample introduction, preparation and extraction on centrifugal microfluidic devices in motion are presented. To achieve this, hybrid fabrication techniques including the use of 3D printers were investigated and a World-to-Disk interface permitting the introduction of a solution gradient to a spinning device was developed. The interaction of integrated mobile magnets with a series of fixed magnets placed below the spinning devices was also investigated resulting in the development of both a magnetically actuated solid sample preparation and a magnetically actuated liquid-solid extraction technique. New automated and miniaturized methods for the analysis of environmentally important species such as polycyclic aromatic hydrocarbons and pesticides in solid samples are presented.
Les polluants ont des impacts importants sur la santé et l'environnement résultant à des restrictions accrues des limites législatives. Cette surveillance environnementale accrue pousse les chimistes analytiques vers l'automatisation et la miniaturisation des méthodes de référence actuelles. L'analyse d'échantillons environnementaux solides bénéficiera de cette envolée par le développement de nouveaux instruments et techniques de manipulation d'échantillon via des dispositifs microfluidiques centrifuges qui intègrent des réactions à étapes multiples sur un dispositif unique.Afin d'étudier et d'optimiser les dispositifs microfluidiques centrifuges en mouvement, des plateformes motorisées qui incluent une caméra, une lumière stroboscopique et une variété d'autres composantes périphériques ont été développées. Celles-ci ont permis le contrôle efficace des dispositifs tout au long des séquences giratoires et l'acquisition simultanée de séries de photographies en arrêt sur image.Des méthodologies sont présentées pour l'introduction, la préparation et l'extraction d'échantillons sur des dispositifs microfluidiques centrifuges en mouvement. Ceci fut réalisé grâce à la recherche de techniques de fabrication hybrides incluant l'utilisation d'imprimantes 3D menant au développement d'une interface permettant l'introduction de solutés à concentrations variables aux dispositifs en mouvement. De plus, l'interaction d'aimants mobiles intégrés avec une série d'aimants fixes placée sous les dispositifs en mouvement a mené au développement des techniques de préparation d'échantillons solides par force magnétique et d'extraction liquide-solide d'échantillons par force magnétique. De nouvelles méthodes automatisées et miniaturisées ont été développées pour l'analyse d'espèces environnementales importantes telles que les hydrocarbures polycycliques aromatisés et les pesticides dans des échantillons solides.
10

Kim, Ho Jun. "Theoretical and numerical studies of chaotic mixing." Diss., Texas A&M University, 2008. http://hdl.handle.net/1969.1/85940.

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Theoretical and numerical studies of chaotic mixing are performed to circumvent the difficulties of efficient mixing, which come from the lack of turbulence in microfluidic devices. In order to carry out efficient and accurate parametric studies and to identify a fully chaotic state, a spectral element algorithm for solution of the incompressible Navier-Stokes and species transport equations is developed. Using Taylor series expansions in time marching, the new algorithm employs an algebraic factorization scheme on multi-dimensional staggered spectral element grids, and extends classical conforming Galerkin formulations to nonconforming spectral elements. Lagrangian particle tracking methods are utilized to study particle dispersion in the mixing device using spectral element and fourth order Runge-Kutta discretizations in space and time, respectively. Comparative studies of five different techniques commonly employed to identify the chaotic strength and mixing efficiency in microfluidic systems are presented to demonstrate the competitive advantages and shortcomings of each method. These are the stirring index based on the box counting method, Poincare sections, finite time Lyapunov exponents, the probability density function of the stretching field, and mixing index inverse, based on the standard deviation of scalar species distribution. Series of numerical simulations are performed by varying the Peclet number (Pe) at fixed kinematic conditions. The mixing length (lm) is characterized as function of the Pe number, and lm ∝ ln(Pe) scaling is demonstrated for fully chaotic cases. Employing the aforementioned techniques, optimum kinematic conditions and the actuation frequency of the stirrer that result in the highest mixing/stirring efficiency are identified in a zeta potential patterned straight micro channel, where a continuous flow is generated by superposition of a steady pressure driven flow and time periodic electroosmotic flow induced by a stream-wise AC electric field. Finally, it is shown that the invariant manifold of hyperbolic periodic point determines the geometry of fast mixing zones in oscillatory flows in two-dimensional cavity.
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Книги з теми "Microfluidic method":

1

Lin, Bingcheng, and S. Basuray. Microfluidics: Technologies and applications. Heidelberg: Springer, 2011.

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2

Lu, Chang, and Scott S. Verbridge, eds. Microfluidic Methods for Molecular Biology. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30019-1.

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3

Krishnendu, Chakrabarty, and Zeng Jun, eds. Design automation methods and tools for microfluidics-based biochips. Dordrecht: Springer, 2006.

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4

Bontoux, Nathalie, Luce Dauphinot, and Marie-Claude Potier. Unravelling single cell genomics: Micro and nanotools. Cambridge, UK: RSC Pub., 2010.

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5

Li, Xiujun, and Zhou Yu. Microfluidic devices for biomedical applications. Cambridge, UK: Woodhead Publishing, 2013.

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6

D, Minteer Shelley, ed. Microfluidic techniques: Reviews and protocols. Totowa, N.J: Humana Press, 2006.

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7

Berthier, Jean. Microdrops and digital microfluidics. Norwich, NY: William Andrew Pub., 2008.

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8

Kilian, Dill, Liu Robin Hui, and Grodzinski Piotr, eds. Microarrays: Preparation, microfluidics, detection methods, and biological applications. New York: Springer, 2009.

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9

D, Zahn Jeffrey, ed. Methods in bioengineering: Biomicrofabrication and biomicrofluidics. Boston: Artech House, 2010.

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10

Bontoux, Nathalie, Luce Dauphinot, and Marie-Claude Potier. Unravelling single cell genomics: Micro and nanotools. Cambridge, UK: RSC Pub., 2010.

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Частини книг з теми "Microfluidic method":

1

Shao, Chenren, and Don L. DeVoe. "Measuring Microchannel Electroosmotic Mobility and Zeta Potential by the Current Monitoring Method." In Microfluidic Diagnostics, 55–63. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-134-9_4.

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2

Occhetta, Paola, Emilia Biffi, and Marco Rasponi. "A Reliable Reversible Bonding Method for Perfused Microfluidic Devices." In Neuromethods, 25–38. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2510-0_2.

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3

Conde, Alvaro J., Ieva Keraite, Nicholas R. Leslie, and Maïwenn Kersaudy-Kerhoas. "Microfluidic Acoustic Method for High Yield Extraction of Cell-Free DNA in Low-Volume Plasma Samples." In Microfluidic Systems for Cancer Diagnosis, 163–80. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3271-0_11.

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4

Jiménez-Torres, José A., David J. Beebe, and Kyung E. Sung. "A Microfluidic Method to Mimic Luminal Structures in the Tumor Microenvironment." In Methods in Molecular Biology, 59–69. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3801-8_5.

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5

Lin, Ching-Hui, Hao-Chen Chang, Don-Ching Lee, Ing-Ming Chiu, and Chia-Hsien Hsu. "Enzyme-Free Dissociation of Neurospheres by a Microfluidic Chip-Based Method." In Methods in Molecular Biology, 289–97. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/7651_2016_348.

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6

Rahul, R., V. Aishwarya, Nikhil Prasad, R. S. Mini, and S. Kumar Ranjith. "Design and Development of Thermoplastic Microfluidic Device for Argentometric Mohr Method." In Fluid Mechanics and Fluid Power, Volume 6, 163–72. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-99-5755-2_19.

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7

Lee, Nae Yoon, Masumi Yamada, and Minoru Seki. "Improved Sample Injection Method Adapting Hydrophobic Passive Valve Systems for Microfluidic Devices." In Micro Total Analysis Systems 2002, 667–69. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-010-0504-3_22.

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8

Yusro, Muhammad. "Emerging Potential on Laser Engraving Method in Fabricating Mold for Microfluidic Technology." In Proceedings of the 2nd International Conference on Electronics, Biomedical Engineering, and Health Informatics, 203–14. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-1804-9_16.

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9

Geertz, Marcel, Sylvie Rockel, and Sebastian J. Maerkl. "A High-Throughput Microfluidic Method for Generating and Characterizing Transcription Factor Mutant Libraries." In Methods in Molecular Biology, 107–23. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-412-4_6.

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10

Lin, Ching-Hui, Hao-Chen Chang, Don-Ching Lee, Ing-Ming Chiu, and Chia-Hsien Hsu. "Erratum to: Enzyme-Free Dissociation of Neurospheres by a Microfluidic Chip-Based Method." In Methods in Molecular Biology, E1. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6550-2_327.

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Тези доповідей конференцій з теми "Microfluidic method":

1

Dunning, Peter D., Pierre E. Sullivan, and Michael J. Schertzer. "Method for Characterization of Passive Mechanical Filtration of Particles in Digital Microfluidic Devices." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-38875.

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The ability to remove unbound biological material from a reaction site has applications in many biological protocols, such as those used to detect pathogens and biomarkers. One specific application where washing is critical is the Enzyme-Linked ImmunoSorbent Assay (ELISA). This protocol requires multiple washing steps to remove multiple reagents from a reaction site. Previous work has suggested that a passive mechanical comb filter can be used to wash particles in digital microfluidic devices. A method for the characterization of passive mechanical filtration of particles in Digital MicroFluidic (DMF) devices is presented in this work. In recent years there has been increased development of Lab-On-A-Chip (LOAC) devices for the automation and miniaturization of biological protocols. One platform for further research is in digital microfluidics. A digital microfluidic device can control the movement of pico-to nanoliter droplets of fluid using electrical signals without the use of pumps, valves, and channels. As such, fluidic pathways are not hardwired and the path of each droplet can be easily reconfigured. This is advantageous in biological protocols requiring the use of multiple reagents. Fabrication of these devices is relatively straight forward, since fluid manipulation is possible without the use of complex components. This work presents a method to characterize the performance of a digital microfluidic device using passive mechanical supernatant dilution via image analysis using a low cost vision system. The primary metric for performance of the device is particle retention after multiple passes through the filter. Repeatability of the process will be examined by characterizing performance of multiple devices using the same filter geometry. Qualitative data on repeatability and effectiveness of the dilution technique will also be attained by observing the ease with which the droplet disengages from the filter and by measuring the quantity of fluid trapped on the filter after each filtration step.
2

Dou, James, Lu Chen, Rakesh Nayyar, and Stewart Aitchison. "A microfluidic based optical particle detection method." In SPIE BiOS, edited by Robert J. Nordstrom and Gerard L. Coté. SPIE, 2012. http://dx.doi.org/10.1117/12.905049.

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3

Galambos, Paul, and Conrad James. "Surface Micromachined Microfluidics: Example Microsystems, Challenges and Opportunities." In ASME 2005 Pacific Rim Technical Conference and Exhibition on Integration and Packaging of MEMS, NEMS, and Electronic Systems collocated with the ASME 2005 Heat Transfer Summer Conference. ASMEDC, 2005. http://dx.doi.org/10.1115/ipack2005-73491.

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A variety of fabrication techniques have been used to make microfluidic microsystems: bulk etching in silicon and glass, plastic molding and machining, and PDMS (silicone) casting. Surprisingly the most widely used method of integrated circuit (IC) fabrication (surface micromachining — SMM) has not been extensively utilized in microfluidics despite its wide use in MEMS. There are economic reasons that SMM is not often used in microfluidics; high infrastructure and start-up costs and relatively long fabrication times: and there are technical reasons; packaging difficulties, dominance of surface forces, and fluid volume scaling issues. However, there are also important technical and economic advantages for SMM microfluidics relating to large-scale batch, no-assembly fabrication, and intimate integration of mechanical, electrical, microfluidic, and nano-scale sub-systems on one chip. In our work at Sandia National Laboratories MDL (Microelectronics Development Lab) we have built on the existing MEMS SMM infrastructure to produce a variety of microfluidic microsystems. These example microsystems illustrate the challenges and opportunities associated with SMM microfluidics. In this paper we briefly discuss two SMM microfluidic microsystems (made in the SUMMiT™ and SwIFT™ processes — www.mdl.sandia.gov/micromachine) in terms of technical challenges and unique SMM microfluidics opportunities. The two example microsystems are a DEP (dielectrophoretic) trap, and a drop ejector patterning system.
4

Pu, J., R. Sochol, Y. Jiang, and L. Lin. "Microfluidic channels fabricated using a lithography-free method." In TRANSDUCERS 2011 - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference. IEEE, 2011. http://dx.doi.org/10.1109/transducers.2011.5969563.

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5

Kim, I., T. An, W. Choi, C. S. Kim, H. J. Cha, and G. Lim. "Immobilization method of escherichia coli for microfluidic application." In 2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII). IEEE, 2013. http://dx.doi.org/10.1109/transducers.2013.6626837.

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6

Lai, Siyi, Yeny Hudiono, Ly J. Lee, Sylvia Daunert, and Marc J. Madou. "Novel bonding method for polymer-based microfluidic platforms." In Micromachining and Microfabrication, edited by Jean Michel Karam and John A. Yasaitis. SPIE, 2001. http://dx.doi.org/10.1117/12.442956.

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7

Singha, Kamalesh, Tuhina Samanta, Hafizur Rahaman, and Parthasarathi Dasguptay. "Method of droplet routing in digital microfluidic biochip." In 2010 IEEE/ASME International Conference on Mechatronic and Embedded Systems and Applications (MESA). IEEE, 2010. http://dx.doi.org/10.1109/mesa.2010.5552059.

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8

Grande, William J., and Gary A. Fino. "Microfluidic Device Fabrication Method Using Direct Thick Film Writing." In ASME 3rd International Conference on Microchannels and Minichannels. ASMEDC, 2005. http://dx.doi.org/10.1115/icmm2005-75059.

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A novel technique based on direct thick film writing has been developed for the rapid prototyping of microfluidic devices. The direct writing process is based on pressure driven dispensing of precursor materials through a micro-capillary tip. The process exhibits wide latitude in both the materials that can be patterned and the substrate formats and shapes that can be accommodated. A fabrication process flow sequence with general applicability to microfluidic devices was developed and its efficacy was demonstrated by the construction of two-input mixer devices. Integration of fluidic components with electrical circuitry was also demonstrated.
9

Chen, Xiaoming, Yukun Ren, Likai Hou, Tianyi Jiang, and Hongyuan Jiang. "Fluid Mixing Using Induced Charge Electro-Osmotic Transverse Flow Actuated by Asymmetrical Driving Electrode Sequence." In ASME 2019 6th International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/mnhmt2019-4181.

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Abstract Microfluid mixing is an essential process in chemical analysis, drug test, and nanoparticle synthesis. Induced charge electro-osmosis (ICEO) has good capability in microfluid mixing for its reconfigurable vortex profile. We found experimentally ICEO transverse flow induced by the asymmetrical driving electrode has a good performance in disturbing the interface of two fluids. Encouraged by these aspects, we proposed a micromixer using ICEO transverse flows actuated by the asymmetrical driving electrode sequence to mix microfluids. We established a simulation model to investigate the evolution of the interface and demonstrate the work principle of this method. Moreover, we numerically explored the effects of device structure, and electrolyte characteristics on the capability of micromixer. Finally, we validated this method experimentally, and studied the effects of voltage intensity, frequency and flow rate on the mixing capability, obtaining mixing efficiency exceeding 94%. This method is a potential alternative in various microfluidic and lab-on-a-chip applications.
10

Khabiry, Masoud, Nader Jalili, and Srinivas Sridhar. "Automated cell counting method for microgroove based microfluidic device." In 2014 40th Annual Northeast Bioengineering Conference (NEBEC). IEEE, 2014. http://dx.doi.org/10.1109/nebec.2014.6972835.

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Звіти організацій з теми "Microfluidic method":

1

Yao, Jennifer, Shalini Tripathi, Eugene Ilton, Bruce McNamara, Nabajit Lahiri, Matthew O'Hara, Shawn Riechers, and Edgar Buck. Corrosion of U233-Doped Uranium Oxide using Microfluidics Methods. Office of Scientific and Technical Information (OSTI), August 2022. http://dx.doi.org/10.2172/1908674.

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