Готові списки джерел за темами / Metabolic interventions

Добірка наукової літератури з теми "Metabolic interventions"

Автор: Grafiati
Опубліковано: 10 грудня 2022
Оновлено: 29 січня 2023

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Статті в журналах з теми "Metabolic interventions"

1

Alexander, L., and J. P. Despres. "Metabolic Syndrome Interventions." MD Conference Express 7, no. 5 (October 1, 2007): 24–25. http://dx.doi.org/10.1177/155989770700700517.

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Aude, Y. Wady, Pedro Mego, and Jawahar L. Mehta. "Metabolic syndrome: dietary interventions." Current Opinion in Cardiology 19, no. 5 (September 2004): 473–79. http://dx.doi.org/10.1097/01.hco.0000134610.68815.05.

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Vargas, Eric J., and Barham K. Abu Dayyeh. "Endoluminal bariatric and metabolic interventions." Techniques in Gastrointestinal Endoscopy 17, no. 4 (October 2015): 171–77. http://dx.doi.org/10.1016/j.tgie.2016.01.006.

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4

Weindruch, R., K. P. Keenan, J. M. Carney, G. Fernandes, R. J. Feuers, R. A. Floyd, J. B. Halter, et al. "Caloric Restriction Mimetics: Metabolic Interventions." Journals of Gerontology Series A: Biological Sciences and Medical Sciences 56, Supplement 1 (March 1, 2001): 20–33. http://dx.doi.org/10.1093/gerona/56.suppl_1.20.

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5

Rosenfeldt, Franklin. "Metabolic interventions in myocardial preservation." AustralAsian Journal of Cardiac and Thoracic Surgery 2, no. 2 (August 1993): 80–82. http://dx.doi.org/10.1016/1037-2091(93)90052-6.

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6

Cortez, Ramiro Marx Alves, Ana Míria de Oliveira Batista, Mariana Rodrigues da Rocha, Isa Moema de Sales Santos, Jayne Ramos Araújo Moura, and Ana Roberta Vilarouca da Silva. "Students’ knowledge of metabolic syndrome after educational intervention." Revista Brasileira de Enfermagem 71, suppl 4 (2018): 1493–99. http://dx.doi.org/10.1590/0034-7167-2017-0342.

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ABSTRACT Objective: To analyze the knowledge of children and adolescents about risk factors for metabolic syndrome (MS) before and after educational interventions. Method: A quasi-experimental, comparative, prospective and intervention study conducted in 2015 and 2016 with 43 students in the city of Picos (state of Piauí-PI). Five health education meetings were held. For the knowledge analysis, was applied a questionnaire at three different moments. Results: Participants’ mean age was 12.6 years (± 2.1), of which 60.5% were female. The ‘More than good’ level of knowledge went from 20.9% to 55.8% after interventions. When evaluated late, students maintained a higher level of knowledge compared to before the interventions. Most said they were able to change their lifestyle after educational meetings. Conclusion: The educational intervention promoted increase of knowledge and stimulated changes in attitudes related to risk factors associated with MS.
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Wang, Guorong. "Analysis of Ketogenic Metabolic Interventions for Obesity." SHS Web of Conferences 144 (2022): 01010. http://dx.doi.org/10.1051/shsconf/202214401010.

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According to statistics and surveys by the World Health Organization, the obesity ratio of people in the world nearly tripled since 1975; in 2016, more than 1.9 billion adults aged 18 and older were overweight. Obesity and overweight are defined as abnormal or excessive fat accumulation that presents a risk to health. Obesity prevention and intervention is a serious health problem facing humanity. This article is an analysis of interventions for obesity from the perspective of ketogenic metabolism, by supplementing exogenous ketones or increasing endogenous ketone levels. By analyzing experimental data on the metabolic mechanisms of ketones, exogenous ketones esters on body weight, food intake and satiety hormones, this paper concludes that exogenous ketones have a positive effect on interventions in obesity. A study of the literature revealed that the involvement of ketogenesis in the process of fat metabolism is still a very vague concept.
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Kim, Gaeun, Ji-Soo Lee, and Soo-Kyoung Lee. "A Technology-Mediated Interventional Approach to the Prevention of Metabolic Syndrome: A Systematic Review and Meta-Analysis." International Journal of Environmental Research and Public Health 18, no. 2 (January 10, 2021): 512. http://dx.doi.org/10.3390/ijerph18020512.

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Background: Technology-mediated interventions help overcome barriers to program delivery and spread metabolic syndrome prevention programs on a large scale. A meta-analysis was performed to evaluate the impact of these technology-mediated interventions on metabolic syndrome prevention. Methods: In this meta-analysis, from 30 January 2018, three databases were searched to evaluate interventions using techniques to propagate diet and exercise lifestyle programs for adult patients with metabolic syndrome or metabolic risk. Results: Search results found 535 citations. Of these, 18 studies met the inclusion criteria analyzed in this article. The median duration of intervention was 4 months and the follow-up period ranged from 1.5 to 30 months. The standardized mean difference (SMD) between the two groups was waist circumference −0.35 (95% CI −0.54, −0.15), triglyceride −0.14 (95% CI −0.26, −0.03), fasting blood glucose −0.31 (95% CI −0.42, −0.19), body weight −1.34 (95% CI −2.04, −0.64), and body mass index −1.36 (95% CI −2.21, −0.51). There was no publication bias in this study. Conclusion: Technology-mediated intervention improved clinically important metabolic syndrome related indicators such as excess body fat around the waist, fasting glucose, and body mass index. These interventions will play an important role in the dissemination of metabolic syndrome prevention programs.
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Kim, Gaeun, Ji-Soo Lee, and Soo-Kyoung Lee. "A Technology-Mediated Interventional Approach to the Prevention of Metabolic Syndrome: A Systematic Review and Meta-Analysis." International Journal of Environmental Research and Public Health 18, no. 2 (January 10, 2021): 512. http://dx.doi.org/10.3390/ijerph18020512.

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Анотація:
Background: Technology-mediated interventions help overcome barriers to program delivery and spread metabolic syndrome prevention programs on a large scale. A meta-analysis was performed to evaluate the impact of these technology-mediated interventions on metabolic syndrome prevention. Methods: In this meta-analysis, from 30 January 2018, three databases were searched to evaluate interventions using techniques to propagate diet and exercise lifestyle programs for adult patients with metabolic syndrome or metabolic risk. Results: Search results found 535 citations. Of these, 18 studies met the inclusion criteria analyzed in this article. The median duration of intervention was 4 months and the follow-up period ranged from 1.5 to 30 months. The standardized mean difference (SMD) between the two groups was waist circumference −0.35 (95% CI −0.54, −0.15), triglyceride −0.14 (95% CI −0.26, −0.03), fasting blood glucose −0.31 (95% CI −0.42, −0.19), body weight −1.34 (95% CI −2.04, −0.64), and body mass index −1.36 (95% CI −2.21, −0.51). There was no publication bias in this study. Conclusion: Technology-mediated intervention improved clinically important metabolic syndrome related indicators such as excess body fat around the waist, fasting glucose, and body mass index. These interventions will play an important role in the dissemination of metabolic syndrome prevention programs.
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Lahsen, Rodolfo, and Marcos Berry. "Surgical interventions to correct metabolic disorders." British Journal of Diabetes & Vascular Disease 10, no. 3 (May 2010): 143–47. http://dx.doi.org/10.1177/1474651410370302.

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Дисертації з теми "Metabolic interventions"

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Ghosh, Nandini. "MOLECULAR ASPECTS OF LIPID METABOLISM IN NUTRITIONAL INTERVENTIONS: FOCUS ON DEGENERATIVE METABOLIC CONDITIONS." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu156346872132189.

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Lim, Chong. "The effects of dietary interventions on metabolic flexibility." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/52457.

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Metabolic flexibility is defined as the ability of an organism to adapt from fuel oxidation to fuel availability. It is well established that obesity results in loss of metabolic flexibility, however, the exact mechanism remains unclear. Therefore, it is critical to understand the mechanism underlying metabolic flexibility to tackle the epidemic of obesity. An energy-restricted diet will lead to weight loss. However, little is known regarding the mechanisms behind the improvement in metabolic flexibility with weight loss following an energy-restricted diet. In investigation 1, I compared the effects of an energy-restricted diet and a control diet over 12 weeks on overweight and obese volunteers to elucidate the underlying mechanism of metabolic flexibility. The results demonstrated that weight loss is associated with significant reductions in body fat composition, waist circumference, hip circumference, visceral fats, blood pressure, and an improvement in postprandial insulin sensitivity. This translates into an improvement in metabolic health and metabolic flexibility. However, the underlying mechanism remained unclear. Furthermore, dietary modification using short chain fatty acids provides an attractive avenue to improve metabolic flexibility. However, the evidence for the role of short chain fatty acids in improving human metabolic flexibility is lacking. In order to investigate the effects of short chain fatty acids on metabolic flexibility, I used encapsulated sodium propionate, which is a novel method to explore its effects on glucose homeostasis. Investigation 2 consists of two parts. The first part of the study was to demonstrate the pharmacokinetic profile of encapsulated sodium propionate. The results demonstrated no significant changes in serum propionate concentrations following ingestion of encapsulated sodium propionate. The second part of the study was designed to establish the most effective dose of sodium propionate in improving glucose homeostasis. Results from this part of the study demonstrated no significant change in beta cell function.
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Kirby, Ricky McCoy. "Effects of Dietary and Exercise Interventions On The Incidence of Metabolic Syndrome." UNF Digital Commons, 2009. http://digitalcommons.unf.edu/etd/200.

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Анотація:
Metabolic syndrome is a serious health problem in the United States. The presence of metabolic syndrome significantly increases the risk of developing type II diabetes and cardiovascular disease by producing a prothrombic state. The prothrombic state that results from the clustering of several independent cardiovascular risk factors within one individual increases the risk of micro and macro vascular changes and eventually to end organ damage. There is considerable evidence to support the serious nature of this medical condition. Medications used to treat the hypertension, diabetic, and dyslipidemia components of metabolic syndrome can be a significant drain on the monthly budget of individuals and families, especially if they do not have health insurance. Diet and exercise programs have been shown to be effective in reducing adiposity and decreasing insulin resistance. These changes in lifestyle may be adjuncts or a low cost alternative to expensive medications for some individuals. The purpose of this project was to identify the effect of an intensive dietary and exercise program on patients with metabolic syndrome. This study even with a small sample size (n = 5) showed that waist size, systolic blood pressure, diastolic blood pressure, and high density lipoprotein levels were trending towards levels that would remove the patient from the diagnosis of metabolic syndrome. The greatest benefit for the general population would result from intervention prior to a diagnosis of hypertension and diabetes and with medication naïve individuals. Early intervention would decrease the cost of medical treatment and hospitalizations.
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Das, Amitava. "Chronic Inflammation: Molecular and Nutritional Interventions of Metabolic Disorder and its Complications." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461254458.

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Kelly, Benjamin M. "Non-pharmacological interventions for the treatment and prevention of cardio-metabolic disease." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/17118.

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In recent years there has been a surge in interest concerning high intensity intermittent exercise training (HIT) due to its ability to confer rapid notable cardio-metabolic health benefits. Specifically, HIT has been shown to improve insulin sensitivity and glycaemic control as well as other cardiovascular health factors after just 2 weeks of training (typically 6 training sessions). This thesis investigated the potential therapeutic role of HIT training within obese cohorts specifically addressing metabolic health, inclusive of inflammatory profiles and glycaemic control.
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Bednarzyk, Michele Smith. "Dietary Interventions to Reduce Metabolic Syndrome in an Uninsured Population: An Evidence-Based Approach." UNF Digital Commons, 2009. http://digitalcommons.unf.edu/etd/207.

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Recent studies show that more than one-third of U.S. adults (over 72 million people) were obese in 2005–2006. This includes 33.3% of men and 35.3% of women. Obesity is a primary factor in the development of metabolic syndrome, a condition that places individuals at high absolute risk of mortality and morbidity. The use of a nutritionally balanced diet aimed at weight reduction has the potential to decrease the prevalence of obesity, therefore reducing the incidence of metabolic syndrome and its consequences. The purpose of this project was to investigate whether individual nutrition counseling would improve the outcomes of patients with metabolic syndrome. A transdisciplinary team of faculty and graduate students from nutrition and nursing served as consultants and educators at a clinic for the uninsured in a southeastern city in the United States. This study was a one-group before-and-after design, with baseline data obtained on patients prior to the practice change. The study ran for six months. The intervention was an evidence-based practice change incorporating intensive dietary program for 19 patients with metabolic syndrome and an evaluation of the effect of that change on lipoproteins, glucose, blood pressure, weight, and waist circumference. Although there were no positive changes in weight or waist circumference, the participants did enjoy a significant decrease in blood pressure, fasting glucose and plasma lipids. None of these changes were significantly associated with the dietary intervention. Based on the most current evidence, the most effective way to reduce risks associated with metabolic syndrome is weight reduction, adequate nutrition, and exercise.
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Zimmerman, Angela D. "Nursing interventions in the care of patients undergoing induced hypothermia." Honors in the Major Thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/531.

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Use of induced hypothermia for the purpose of lowering intracranial pressure and preserving neuronal function has increased as research data reveals a trend of positive outcomes in patients treated with this therapy. Recently induced hypothermia following cardiac arrest due to ventricular fibrillation has been deemed successful. Current research has expanded to evaluate the effectiveness of induced hypothermia as a treatment modality for severe stroke and head trauma. In spite of its efficacy, complications exist with this treatment modality. The purpose of this literature review is to examine potential complications secondary to induced hypothermia and highlight the nurse's role in managing patient care. At the present, patient protocols for induced hypothermia are lacking. The success of treatment is largely dependent on the skill of the healthcare team to prevent further harm and enhance therapeutic outcomes by providing astute assessment and management of complications in patients undergoing induced hypothermia. The desired outcome of this review is to promote integration of research in the development of evidence-based protocols for induced hypothermia.
B.S.N.
Bachelors
Nursing
Nursing
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8

Solomon, Thomas Phillip James. "Measuring insulin sensitivity and the effect of alternative dietary interventions and exercise on metabolic control." Thesis, University of Birmingham, 2007. http://etheses.bham.ac.uk//id/eprint/22/.

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The metabolic syndrome is highly prevalent in western society, and the numbers affected by obesity and diabetes continue to rise. This thesis reviews the mechanisms at play and the gaps in the literature that, if filled, may increase knowledge of treatment regimes for affected individuals. Experimentally, it was demonstrated that the oral glucose tolerance test can be a reliable tool to measure insulin sensitivity following adequate dietary and exercise control. Acute and chronic cinnamon ingestion was shown to improve insulin sensitivity. Feeding frequency was found to alter insulin and ghrelin responses and relationships following mixed-meal ingestion. And finally, postprandial lipaemia was found to be attenuated for up to 24 hours following moderate-intensity exercise, illustrating the requirement of daily exercise. In summary, oral glucose tolerance tests are suitable for experimental interventions; and the clinical management of factors associated with the metabolic syndrome should perhaps consider dietary supplements, meal frequency, and exercise timing in addition to the traditional dietary and physical activity guidelines currently in practice.
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Micaux, Obol Claire. "Treatment and prevention of metabolic syndrome: The challenge of achieving behavior changes through lifestyle interventions : a literature review." Thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-35726.

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Kapser-Fischer, Ingrid Petra [Verfasser], Matthias H. [Akademischer Betreuer] Tschöp, Matthias H. [Gutachter] Tschöp, and Martin [Gutachter] Klingenspor. "Dietary interventions in C57BL/6 mice and their interplay with selected metabolic and genetic parameters / Ingrid Petra Kapser-Fischer ; Gutachter: Matthias H. Tschöp, Martin Klingenspor ; Betreuer: Matthias H. Tschöp." München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1202921868/34.

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Книги з теми "Metabolic interventions"

1

Beard, Jonathan C. Illicit drug use: Acute and chronic pharmacological intervention. Salisbury, Wiltshire: Quay Books, 1995.

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2

Shattock, Paul. Autism as a metabolic disorder: Guidelines for gluten and casein- free dietary intervention. 2nd ed. Sunderland: Autism Research Unit, 2001.

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Nadjmi, Maschallah, ed. Imaging of Brain Metabolism Spine and Cord Interventional Neuroradiology Free Communications. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74337-5.

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4

George, Weinbaum, Giles Ralph E, Krell Robert D, New York Academy of Sciences., and American Thoracic Society, eds. Pulmonary emphysema: The rationale for therapeutic intervention. New York, N.Y: New York Academy of Sciences, 1991.

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5

Nordin, B. E. C. Metabolic consequences of the menopause a cross-sectional, longitudional, and intervention study on 557 normal postmenopausal women. New York: Springer, 1987.

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6

1921-, Kinney John M., Tucker Hugh N, and Clintec International Horizons Conference (3rd : 1996 : Amsterdam, Netherlands), eds. Physiology, stress, and malnutrition: Functional correlates, nutritional intervention. Philadelphia: Lippincott-Raven, 1997.

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7

Management of lipid disorders: A basis and guide for therapeutic intervention. Baltimore, MD: William & Wilkins, 1997.

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8

Congress, European Society of Neuroradiology. Imaging of brain metabolism, spine and cord interventional neuroradiology free communications: XVth Congress of the European Society of Neuroradiology, Würzburg, September 13th-17th, 1988. Berlin: Springer-Verlag, 1989.

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9

Ken'ichi, Kitani, Goto S, and Aoba A, eds. Pharmacological intervention in aging and age-associated disorders: Proceedings of the Sixth Congress of the International Association of Biomedical Gerontology. New York: New York Academy of Sciences, 1996.

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10

The packaging designer's book of patterns. Hoboken: Wiley, 2012.

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Частини книг з теми "Metabolic interventions"

1

Kumari, Bhawna, Akanksha Sharma, and Umesh C. S. Yadav. "Metabolic Syndrome and Nutritional Interventions." In Functional Food and Human Health, 257–76. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-1123-9_13.

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Iskandar, Mazen E., and Elliot R. Goodman. "Newer Endoluminal Interventions for Obesity." In Obesity, Bariatric and Metabolic Surgery, 499–504. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-04343-2_52.

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Syed, Abdus Samad, Mazen E. Iskandar, and Elliot R. Goodman. "Newer Endoluminal Interventions for Obesity." In Obesity, Bariatric and Metabolic Surgery, 1–8. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-54064-7_52-1.

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Engberding, Niels, and Nanette K. Wenger. "Gender Differences in Coronary Risk Factors and Risk Interventions." In Atlas of Atherosclerosis and Metabolic Syndrome, 253–99. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-5839-6_12.

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Jonscher, Karen R., and Kimberley D. Bruce. "Current Models of Fatty Liver Disease; New Insights, Therapeutic Targets and Interventions." In Reviews on Biomarker Studies of Metabolic and Metabolism-Related Disorders, 33–58. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-12668-1_3.

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Majamaa, Kari, Harri Rusanen, Anne Remes, and Ilmo E. Hassinen. "Metabolic interventions against complex I deficiency in MELAS syndrome." In Detection of Mitochondrial Diseases, 291–96. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-6111-8_45.

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Talib, Wamidh H., Muna Barakat, and Lina T. Al Kury. "Hyperhomocysteinemia and Cancer: The Role of Natural Products and Nutritional Interventions." In Nutritional Management and Metabolic Aspects of Hyperhomocysteinemia, 9–32. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57839-8_2.

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Marx, T., A. Clewell, and M. Barnes. "Metabolic Syndrome." In Bioactive Food as Dietary Interventions for Diabetes, 503–17. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-397153-1.00206-7.

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Gabrielle, Lyon, and Jamie I. Baum. "Metabolic Interventions for Sarcopenic Obesity." In Metabolic Therapies in Orthopedics, Second Edition, 223–38. CRC Press, 2018. http://dx.doi.org/10.1201/9781315176079-12.

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Patel, Tarak H., and John A. Carrino. "Percutaneous Spine Interventions." In Imaging of Arthritis and Metabolic Bone Disease, 699–710. Elsevier, 2009. http://dx.doi.org/10.1016/b978-0-323-04177-5.00040-9.

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Тези доповідей конференцій з теми "Metabolic interventions"

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Rajaram, Narasimhan. "Molecular and Metabolic Imaging of Tumors to Inform Therapeutic Interventions." In Frontiers in Optics. Washington, D.C.: OSA, 2014. http://dx.doi.org/10.1364/fio.2014.fm3f.4.

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Sinaga, Lasrika S., Ciciilya Candi, and Mardiati Nadjib. "Nutritional Interventions to Reduce Stunting in Developing Countries: A Systematic Review." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.03.78.

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ABSTRACT Background: Childhood stunting remains a major malnutritional problem in developing countries. Stunting occurred the adverse effects on children’s health in the short and long term, including failure to thrive, impairment of cognitive and motor development, stunted stature, metabolic disorders, and decreased intellectual capacity. Integrated nutritional intervention is important to prevent stunting. This study aimed to identify the nutritional interventions to reduce stunting in developing countries. Subjects and Method: A systematic review was conducted by searching from Wiley Online Library, and ProQuest databases. The research question was formulated in PICO-S format: (1) Population, (2) Intervention, (3) Comparison, (4) Outcome, and (5) Study design. The next step was identification, screening, and checking the eligibility of the studies. The keywords were nutrition intervention and stunting reduction. The inclusion criteria were openly accessed and English-language articles published between 2019 to 2020. The searched articles were conducted identification, screening, and eligibility. The data were reported by PRISMA flow chart. Results: Nine articles met the inclusion criteria. Integrated efforts to reduce stunting incidence were carried out through sensitive and specific nutritional interventions. A holistic approach involving the non-health sectors had significant impacts. Some limitations had still occurred in the capacity of implementing qualified nutritional interventions and their utilization. Conclusion: Implementation of nutritional interventions have been focused in developing countries with different approaches to reduce stunting incidence. Keyword: nutritional intervention, stunting, developing countries Correspondence: Lasrika S Sinaga. Masters Program in Public Health, Faculty of Public Health, Universitas Indonesia. Jl. Margonda Raya, Pondok Cina, Beji, Depok, 16424, East Java. Email: lasrikass20@gmail.com. Mobile: +62 81382375618. DOI: https://doi.org/10.26911/the7thicph.03.78
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Senhorinha, Gláucia Maria, Arlys Emanuel Mendes da Silva Santos, and Douglas Daniel Dophine. "The role of metabolic syndrome in Alzheimer’s disease." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.319.

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Background: Metabolic syndrome (MS) leads to the deposits formation of insoluble protein aggregates, neuroinflammation, oxidative stress, neuronal insulin resistance, progressive insulin resistance, desensitization and β-amyloid amyloidosis in the brain, besides direct ischemic effects which are closely associated with Alzheimer’s disease (AD).1 Objectives: The present study seeks to understand the role of the metabolic syndrome in the pathophysiology of Alzheimer’s disease and to describe preventive and therapeutic interventions. Methods: PUBMED and Web of Science were the databases used, the following descriptors were used to search the articles: “Alzheimer Disease” OR “Alzheimer Dementia” AND “Metabolic Syndrome”. Results: The studies in general have shown that MS is related to AD through brain insulin resistance, triggered by oxidative stress and neuroinflammation. It is related to the progressive atrophy of brain regions involved in the progression of AD. Insulin resistance in the brain is related to the progressive atrophy of the brain regions from initial progression of AD. These regions are cingulate cortices, medial temporal lobe, prefrontal gyri and other regions.³ Thus, there is an inhibition of the mechanisms of beta-amyloid removal, leading to its accumulation, which generates neuroinflammation, that in turn potentiates insulin resistance in the central nervous system, contributing to the genesis and progression of cognitive damage.2,3 Conclusions: Insulin resistance plays a major role in the initiation and perpetuation of cognitive impairment in AD. Furthermore, the components of the MS associated with AD, when treated with preventive and therapeutic measures, break this association by promoting rebalancing of the metabolism.
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Mendonça, Bárbara Gazolla de, Lara Lopardi de Souza Leite, Carolina Falconi Amorim, Flávio Welinton Martins Cruz, and Gustavo Cosendey Portes. "The relation between the menopause transition with higher rates of Alzheimer in the female gender: a literature review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.577.

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Introduction: The reproductive senescence and the complete exhaustion of the germ cells result in processes capable of provoking changes in the hormone profile of women. The decrease in the bioenergetic metabolism during the menopause transition (MT), due to modifications in the estrogen levels, can be substrate for neurological dysfunctions. The physiopathological mechanisms of the Alzheimer’s Disease (AD) are activated years before the symptoms and coincide with MT, making the female gender a risk factor. The review aims on analyzing the higher rates of AD in the female gender, based on physiological changes that occur in the MT. Methods: Literature review based on articles from the PubMed database. Results: Were compared results from cerebral images of women in MT with cognitively normal men with the same age. In the women were found alterations such as abnormalities in the biomarkers of AD and reduction of the cerebral metabolic rate. It was noticed that women in the post menopause presented hypometabolism in the same cerebral regions as patients with AD and a reduction of the mitochondrial cytochrome oxidase of the platelets. Conclusion: The study presented evident bioenergetic factors that corroborate to the relation of MT and higher incidence of AD in the female gender. This way, such transition represents a window of opportunity for possible therapeutic interventions.
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Augustus, Eden, Stephanie Whiteman, Emily Haynes, Cornelia Guell, Cassandra Ash, Lili Jia, Karyn Morrissey, et al. "OP42 The impact of interventions aimed at improving nutritional status and metabolic health in small island developing states: a systematic review." In Society for Social Medicine Annual Scientific Meeting Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jech-2022-ssmabstracts.42.

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Cozzo, Alyssa J., Michael F. Coleman, Ciara H. O'Flanagan, Jane B. Pearce, Magdalena A. Rainey, and Stephen D. Hursting. "Abstract 5278: Separate and combined effects of metabolic reprogramming interventions, autophagy inhibition, and carboplatin on murine triple-negative breast cancer cells." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-5278.

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Cozzo, Alyssa J., Michael F. Coleman, Ciara H. O'Flanagan, Jane B. Pearce, Magdalena A. Rainey, and Stephen D. Hursting. "Abstract 5278: Separate and combined effects of metabolic reprogramming interventions, autophagy inhibition, and carboplatin on murine triple-negative breast cancer cells." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-5278.

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Bijman, Laura, Rajay Narain, Mimi Chen, and Hareesh Joshi. "197 Introduction of a multidisciplinary cardiac metabolic clinic in a UK tertiary cardiology centre: early activity, interventions and potential for cardiovascular risk optimisation." In British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021. BMJ Publishing Group Ltd and British Cardiovascular Society, 2021. http://dx.doi.org/10.1136/heartjnl-2021-bcs.193.

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Michalski, Marie-Caroline, Cecile Vors, Corinne Malpuech-Brugere, Dominique Rainteau, Emilie Gauliard, Hubert Vidal, Lemlih Ouchchane, and Lydie Humbert. "Impact of milk polar lipid supplementation on postprandial bile acid composition." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/pklq6155.

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Justification: Bile acids (BA) are the end products of cholesterol catabolism and may act as signalling molecules and metabolic regulators of energy homeostasis. Disorders in BA metabolism can lead to liver and cardiovascular diseases. In a 4-week double-blind RCT (VALOBAB-C), we demonstrated that the daily consumption of a cream cheese enriched with 3 or 5g of milk polar lipids (PL) improved lipid metabolism by reducing hypercholesterolemia in overweight postmenopausal women. Objective: We aimed to determine the effect of milk PL on circulating BA in the fasting and postprandial state. Methods: In the VALOBAB-C trial, postprandial metabolic explorations (0-480min) were performed before and after the intervention, including a standardized high fat-high sucrose breakfast at fasting and a standardized lunch containing the test cream cheese at 240 min. Fasting and postprandial serum bile acid composition was analysed by HPLC-MS/MS. Results: The milk PL intervention slightly increased total fasting BA concentrations (ΔAfter-Before) (PPL=0.03), with no significant effect on BA species profile (% of total BA). Total BA concentration was not impacted during the postprandial period, but the primary/secondary BA ratio was significantly decreased in both milk PL groups versus control. Milk PL decreased the relative abundance of primary BA (PPL=0.02), increased Tauro-conjugated BA (Pgroup=0.02) and highly decreased Glyco-conjugated BA. Proportions of several species were also decreased during the postprandial period, among which GLCA (glycolithocholic acid). The latter is derived from lithocholic acid, whose accumulation is toxic. Such results provide new insights in the knowledge of BA metabolism, and a potential link with the cholesterol-lowering effects of milk PL deserves to be investigated. Significance of the research to the AOCS membership: H&N, EAT and PL division members can be interested by this research regarding lipid ingredients of functional interest and their impact on relevant biomarkers involved in lipid metabolism.
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Andrade, Dariana Rodrigues, Letícia Mendes de Lima, Luis Henrique Goes Hamati Rosa, and Edvaldo Cardoso. "Brain-gut-microbiota axis in motor disorders." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.401.

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Introduction: There seems to be a strong relationship and influence on the brain-gut- microbiota axis in the control and prevention of several diseases, including degenerative diseases that are related to motor disorders. Objectives: To analyze the relationship between movement disorders and the intestinal microbiota. Methods: Integrative review performed at PUBMED, using the descriptors Movement disorder and intestinal microbiota, in the last five years and having as inclusion criteria complete texts in English. Results: The literature suggests that the intestinal microbiota regulates the activation of microglia through the production of bacteria metabolites. Gut dysbiosis is believed to generate metabolic disorders with decreased production of neuroprotective factors, increased pro-inflammatory cytokines, production of neurotoxins, and a misdirected immune response. Metabolites produced by an altered microbiota seem to enter the circulation and affect neurological function. Braak’s hypothesis postulates that aberrant accumulation of α-synuclein (αSyn), a central component of the pathophysiology of Parkinson’s disease (PD), begins in the intestine and propagates through the vagus nerve to the brain, given that αSyn inclusions previously arise in the enteric nervous system and glossopharyngeal and vagus nerves, and vagotomized individuals have reduced risk of PD. Conclusion: The identification of the microbiota or its altered metabolites may serve as biomarkers, or even drug targets for the treatment of diseases of the central nervous system. The microbiota can be modulated through antibiotic therapy, fecal microbiota transplantation, prebiotic supplementation, dietary interventions and many other potential methods.
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Звіти організацій з теми "Metabolic interventions"

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Mateș, Letiția, Marius Emil Rusu, Ionel Fizeșan, Daniela-Saveta Popa, and Daniel Leucuța. Walnut intake interventions targeting biomarkers of metabolic syndrome and inflammation in middle-aged and older adults: a systematic review and meta-analysis of randomized controlled trials research protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2022. http://dx.doi.org/10.37766/inplasy2022.6.0058.

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Review question / Objective: The aim of this study was to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) in order to properly examine the evidence on the effects of walnut consumption on chosen indicators of inflammation and metabolic syndrome in mature adults. Condition being studied: Metabolic syndrome (MetS), chronic, low-grade inflammation, and oxidative stress are all important risk factors for morbidity and death, with a higher frequency in the elderly population. Information sources: We conducted a comprehensive search in five databases: Pubmed, EMBASE, Scopus, Cochrane, ClinicalTrials, from inception.
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Wang, Xiao, Hong Shen, Yujie Liang, Yixin Wang, Meiqi Zhang, and Hongtao Ma. Effects of physical activity interventions for post-COVID-19 patients: A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0036.

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Review question / Objective: Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has caused a huge impact in many countries and has attracted great attention from countries around the world. However, since the outbreak of the COVID-19 pandemic, most attention has focused on containing transmission and addressing the surge of critically ill patients in acute care settings. As we enter the second phase of the pandemic, emphasis must evolve to post care of COVID-19 survivors. A variety of persistent symptoms, such as severe fatigue, shortness of breath, and attention disorder have been reported at several months after the onset of the infection. We urgently need to identify safe and effective COVID-19 rehabilitative strategies. Overwhelming evidence exists that physical activity produces short-, middle- and long-term health benefits that prevent, delay, mitigate and even reverse a large number of metabolic, pulmonary and cardiovascular diseases. The purpose of this study was to evaluate the effects of physical activity interventions for rehabilitation of post-covid-19 patient and provide a reliable method and credible evidence to improve the prognosis of post-COVID-19 patients via systematic review and meta-analysis.
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Wang, Jiajie, Wei Huang, Yanji Zhang, Zhengrong Zhao, and Zhongyu Zhou. Acupuncture and related interventions for the treatment of obesity: protocol for a scoping review of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0099.

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Review question / Objective: The purpose of this study is to summarize the characteristics of RCT in the treatment of obesity by acupuncture and other related intervention measures, so as to enhance evidence-based clinical practice about acupuncture for obesity. Condition being studied: Obesity is a chronic metabolic disease that is defined as a body's excessive accumulation or abnormal distribution of total or local fat content. Their complications such as Type II diabetes mellitus, hyperlipidemia, and cardiovascular diseases are strongly related to higher risks of mortality. In recent years, with the changes in diet structure and living habits, 1.9 billion adults were overweight and over 650 million were obese according to the report by the WHO in 2016. Acupuncture is a characteristic therapy of traditional Chinese medicine, which is effective and safe for the treatment of simple obesity. In recent years, many RCTs using acupuncture in simple obesity were carried out within and outside of China. But currently, acupuncture treatment has no uniform standard, and there are a number of problems with this current clinical application of modern Chinese Medicine. Unfortunately, there is an absence of high-quality data supporting their use. This scoping review aims to summarize the characteristics of RCT in the treatment of obesity by acupuncture and other related intervention measures, so as to enhance evidence-based clinical practice about acupuncture and moxibustion for obesity.
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Cheng, Yan. Targeting Energy Metabolic Pathways as Therapeutic Intervention for Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 2012. http://dx.doi.org/10.21236/ada573205.

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Cheng, Yan. Targeting Energy Metabolic Pathways as Therapeutic Intervention for Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 2013. http://dx.doi.org/10.21236/ada592686.

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Hebert, James R. Phase I Induction and Estrogen Metabolism in Women with and without Breast Cancer and in Response to a Dietary Intervention. Fort Belvoir, VA: Defense Technical Information Center, October 2004. http://dx.doi.org/10.21236/ada434810.

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Ghosal, Samit, and Binayak Sinha. The cardiovascular benefits of GLP1-RA are directly related to their positive effect on glycaemic control: A meta-regression analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2022. http://dx.doi.org/10.37766/inplasy2022.1.0071.

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Review question / Objective: P (patient population) = Type 2 diabetes patients with high CV risk or established atherosclerotic cardiovascular disease; I (intervention) = Received drugs: GLP1-RA; C (control group) = Compared to a control group that received a placebo; O (outcome) = Outcomes of interest included primary CV outcomes (MACE, CV death, MI, and Stroke). Condition being studied: To explore whether the heterogeneity associated with the primary outcomes benefits can be attributed to the metabolic improvements associated with GLP1-RA. The plan is to use HBA1c, weight, and SBP reduction as moderators attempting to explain any variance between the true and observed effect size.
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Wilcox, Sara. The Effect of a Home-Based Walking Intervention on Quality of Life Body Composition and Estrogen Metabolism in Postmenopausal Breast Cancer Survivors. Fort Belvoir, VA: Defense Technical Information Center, September 2003. http://dx.doi.org/10.21236/ada421781.

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Wilcox, Sara. The Effect of a Home-Based Walking Intervention on Quality of Life, Body Composition, and Estrogen Metabolism in Postmenopausal Breast Cancer Survivors. Fort Belvoir, VA: Defense Technical Information Center, September 2006. http://dx.doi.org/10.21236/ada460108.

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Jin, Dachuan, Gao Peng, Shunqin Jin, Tao Zhou, Baoqiang Guo, and Guangming Li. Comparison of therapeutic effects of anti-diabetic drugs on non-alcoholic fatty liver disease patients without diabetes: A network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0014.

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Review question / Objective: To evaluate the efficacy of different anti-diabetic drugs in the treatment of non-diabetic non-alcoholic disease by network meta-analysis, and find the best intervention. Condition being studied: Non-alcoholic fatty liver disease (NAFLD) refers to the disease in which the liver fat content exceeds 5%, and excludes the secondary causes of alcohol, infection, drugs or other specific metabolic diseases. As a spectrum of disorders, it includes hepatocyte steatosis and steatohepatitis at the initial stage, liver fibrosis at the later stage, cirrhosis at the final stage, and even liver cancer. Nowadays Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in the world with an incidence rate as high as 25% which has been rising steadily worldwide in the past 30 years. Currently there are still no approved specific therapeutic agents and global treatment guidelines for NAFLD. For non-diabetic NAFLD, there is far from a consensus, too.
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