Готові списки джерел за темами / Medicinal substances

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Добірка наукової літератури з теми "Medicinal substances"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 травня 2022

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Статті в журналах з теми "Medicinal substances"

Grincevičienė, Švitrigailė. "COUNSELLING OF PREGNANT WOMEN AT THE PHARMACY ABOUT RATIONAL USE OF MEDICINAL SUBSTANCES: ASSOCIATION WITH AGE AND EDUCATION OF PHARMACY SPECIALISTS." Visuomenės sveikata 23, no. 2 (May 3, 2013): 81–84. http://dx.doi.org/10.5200/sm-hs.2013.050.

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Pharmacy specialists are responsible for counsel ling about rational use of medicinal substance in so ciety, but not all of them provide advice for the pa tients. So the aim of this study was to analyze the association between counselling of pregnant wom en at Lithuanian pharmacies about rational use of medicinal substances and pharmacy specialist’s age and educational background. Methods. Random sample of Lithuanian pharmacy specialists (N = 440) was anonymously questioned during the period of March-October, 2012. “FIP reference paper on the effective utilization of pharmacists in improving maternal, newborn and child health” was used for the development of questions about the counselling of pregnant women about rational use of medicinal substances. Results. The odds ratio of more frequent counselling was higher in the case of millennial generation comparing with baby boomers (OR = 3.521 (CI 95% = 6.135 – 2.020)). Higher proportion of pharmacists, compared to pharmacy technicians (p< 0.05), were counselling about rational use of synthetized medicinal substances and non-pharmacological alternatives (millennial generation) and almost all topics of rational use of medicinal substances (baby boomers). Conclusions. Age was associated with the frequency of counselling about rational use of medicinal substances. Age and educational background was associated with counselling topics during pregnancy.

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Purnhagen, Kai. "On How to Assess a Medicinal Product By Function." European Journal of Risk Regulation 1, no. 1 (March 2010): 90–92. http://dx.doi.org/10.1017/s1867299x00000131.

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Article 1(2) of Directive 2001/83 on the Community code relating to medicinal products for human use, as amended by Directive 2004/27 must, apart from the case of substances or combinations of substances intended for the purpose of making a medical diagnosis, be interpreted as meaning that a product which includes in its composition a substance which has a physiological effect when used in a particular dosage is not a medicinal product by function where, having regard to its content in active substances and under normal conditions of use, it constitutes a risk to health without, however, being capable of restoring, correcting or modifying physiological functions in human beings (…) (official headnote).

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Beissebekov, M., R. Iminova, G. Kayralapova, Bates Kudaybergenova, Shynar Zhumagaliyeva, M. Beysebekov, and Zharylkasyn Abilov. "Organo-mineral carriers of medicinal substances." Chemical Bulletin of Kazakh National University, no. 3 (September 25, 2012): 197. http://dx.doi.org/10.15328/chemb_2012_3197-202.

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Ren, Xiaolei, Kaiser Abdulkerim, Xiaorui Fu, Xia Liu, Shuangshuang Ma, Juan Wang, Siqi Liu, Jiarui Wu, and Xueyong Wang. "Metabolomics research on Tibetan medicinal substances." Journal of Traditional Chinese Medical Sciences 2, no. 2 (April 2015): 127–31. http://dx.doi.org/10.1016/j.jtcms.2016.02.002.

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Morris, Craig. "Medicinal Cannabis Users Downplaying and Shifting Stigma: Articulations of the ‘Natural’, of What Is/Is Not a ‘Drug’ and Oppositions with ‘Chemical’ Substances." Sociological Research Online 25, no. 3 (September 18, 2019): 350–68. http://dx.doi.org/10.1177/1360780419870814.

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While sympathy exists among the public for chronically ill and/or disabled people who use cannabis medicinally, cannabis remains a prohibited substance in the UK. How do medicinal cannabis users negotiate this potential stigma when talking about their use of this substance? I reflect on the spoken discourses of 10 medicinal cannabis users (from a sample of 32), obtained by way of qualitative interviews, adopting a critical discourse analysis approach to the data. Specifically, I focus on their articulations around three related themes: cannabis as a ‘natural’ substance, discursive oppositions between cannabis and other substances, and articulations about what is/is not a ‘drug’. I examine how participants articulated these themes in ways that attempted to negotiate the potential for stigma that talking about their cannabis use involved. I found they used rhetorical strategies that downplay their own deviance, attempt to shift the application of stigma to users of other substances, or both. I argue that the more powerful the discursive resources that are articulated, the less rhetorical work an individual has to do to negotiate positive moral standing in an encounter. I also consider to what degree these articulations involved constructions emphasising individual self-control. I argue participants emphasise their individual self-control by asserting that cannabis is a ‘natural’ substance (connoting less inherent risk).

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Shurshina, Angela, Elena Kulish, and Roman Lazdin. "Study of Kinetics of Medicinal Substances Release from Chitosan Films." Chemistry & Chemical Technology 9, no. 3 (September 15, 2015): 319–23. http://dx.doi.org/10.23939/chcht09.03.319.

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Peryea, Tyler, Noel Southall, Mitch Miller, Daniel Katzel, Niko Anderson, Jorge Neyra, Sarah Stemann, et al. "Global Substance Registration System: consistent scientific descriptions for substances related to health." Nucleic Acids Research 49, no. D1 (November 2, 2020): D1179—D1185. http://dx.doi.org/10.1093/nar/gkaa962.

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Abstract The US Food and Drug Administration (FDA) and the National Center for Advancing Translational Sciences (NCATS) have collaborated to publish rigorous scientific descriptions of substances relevant to regulated products. The FDA has adopted the global ISO 11238 data standard for the identification of substances in medicinal products and has populated a database to organize the agency's regulatory submissions and marketed products data. NCATS has worked with FDA to develop the Global Substance Registration System (GSRS) and produce a non-proprietary version of the database for public benefit. In 2019, more than half of all new drugs in clinical development were proteins, nucleic acid therapeutics, polymer products, structurally diverse natural products or cellular therapies. While multiple databases of small molecule chemical structures are available, this resource is unique in its application of regulatory standards for the identification of medicinal substances and its robust support for other substances in addition to small molecules. This public, manually curated dataset provides unique ingredient identifiers (UNIIs) and detailed descriptions for over 100 000 substances that are particularly relevant to medicine and translational research. The dataset can be accessed and queried at https://gsrs.ncats.nih.gov/app/substances.

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Porseva, N. Yu, A. V. Soloninina, and N. B. Rostova. "On problems and algorithm of prescribing combined medicinal preparations, containing small quantities of narcotic drugs and psychotropic substances." Perm Medical Journal 35, no. 2 (April 15, 2018): 59–67. http://dx.doi.org/10.17816/pmj35259-67.

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Aim. To analyze the regulating documents and work out the algorithm of prescribing combined medicinal preparations, containing small quantities of narcotic drugs, psychotropic substances, their precursors and other pharmacological active substances. Materials and methods. The normative documents, regulating the order of prescribing and selling combined medicinal preparations, containing narcotic drugs, psychotropic substances and their precursors were analyzed. Results. Some normative documents to regulate the order of prescribing combined medicinal preparations, containing narcotic drugs and psychotropic substances, present problems. To simplify the procedure of prescribing such medicinal preparations, there was suggested an algorithm, explaining: the choice of prescription form; conditions of prescribing combined medicinal preparation by trade name; terms of prescription validity and possibilities of their prolongation; regulated possibilities for exceeding norms of prescribing medicinal preparations and order of their registration. Conclusions. The suggested algorithm of the order of prescription will promote observation of requirements of the existing normative acts.

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Mahajna, Jamal A., Majed Yassin, and Ben-Zion Zaidman. "Medicinal Mushroom Substances as Cancer Molecular Therapy." International Journal of Medicinal Mushrooms 7, no. 3 (2005): 351–52. http://dx.doi.org/10.1615/intjmedmushr.v7.i3.150.

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G, Odontuya. "Ethnopharmacology – active substances and medicines." Bulletin of the Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences, no. 7 (December 23, 2019): 33–40. http://dx.doi.org/10.5564/bicct.v0i7.1271.

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Ethnopharmacological evidence and knowledge of medicinal plants, as well as their traditional usage in folk medicine could become an important guide for discovering and studying their pharmacologically active substances. Of the 122 officially recognized medicinal plant-based medicines worldwide, 80 % are derived from either ethnomedical practice or traditional usages by the local populations. Consequently, this illustrates the effectiveness of identifying active substances from the ethnomedical practices of the related medicinal plants. Today, pharmaceutical companies have started to direct research activities for discovering active compounds from natural sources, including medicinal plants, due to an increase in the lack of precise medications available for treating certain medical complications, as well as a comparatively high level of side effects and toxicity in synthetic medicines. Угсаатны эм судлал –эмийн идэвхт бодис, шинэ эм бэлдмэлийн эх сурвалж болох нь Хураангуй: Эмийн ургамлыг уламжлалт анагаах ухаанд хэрэглэдэг талаарх угсаатны эм судлалын мэдлэг, мэдээлэл нь ургамлаас эмчилгээний идэвхтбодисыг ялган судлах, ашиглахадчухал удирдамж болдог. Эмийн ургамлаас гарган авсан 122 бодис нь эм болж дэлхийн эмийн зах зээлд нийлүүлэгдсэн байдаг бөгөөд эдгээрийн 80 % нь тухайн өвчнийг анагаахад орон нутгийн ард түмний хэрэглэж заншсан ургамлаас ялгагдаж, угсаатны эм судлалын судалгааны үр дүнд бүтээгдсэн онцлогтой. Орчин үед зарим өвчний эмчилгээнд тохирох эм бэлдмэл одоо болтол гараагүй, нийлэг эмийн гаж нөлөө, хоруу чанар их зэрэг олон шалтгааны улмаас эмийн компаниуд байгалиас, ургамлаас эмийн идэвхтбодисыг шинээр илрүүлэн эм бэлдмэл гарган авах хандлага, сонирхол улам бүр өсөж байна. Түлхүүр үг: Ургамал, угсаатны ам судлал, эмийн идэвхт бодис, эм бэлдмэл

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Більше джерел

Дисертації з теми "Medicinal substances"

Belo, Cristóvão Ramiro. "Bétele (Piper Betle Linn): Análise de Metabolitos e acção sobre a Acetilcolinesterase." Dissertação, Faculdade de Farmácia da Universidade do Porto, 2009. http://hdl.handle.net/10216/20777.

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Mestrado em Controlo de Qualidade
MSc in Quality Control
Piper betle L., conhecida como bétele, é uma espécie que se desenvolve largamente nos países do Sudeste Asiático, onde as suas folhas são económica e medicinalmente importantes. Para determinar o maior número possível de compostos voláteis e semivoláteis, as folhas foram sujeitas as diferentes processos de extracção, nomeadamente headspace - microextracção em fase sólida (HS-SPME), hidrodestilação e extracção por Soxhlet, e posteriormente analisadas por GC/MS, o que permitiu identificar 50 compostos, distribuídos por várias classes químicas, 23 dos quais foram descritos pela primeira vez. As diferentes técnicas permitiram a extracção de compostos distintos, sendo a HS-SPME aquela com que se obteve o perfil mais completo e com que se determinou maior teor de compostos. Dentro deste processo os melhores resultados foram obtidos utilizando a fibra revestida com divinilbenzeno/polidimetilsiloxano (DVB/PDMS). Considerando que a espécie é vulgarmente mascada, o seu extracto aquoso também foi analisado, tendo sido caracterizados apenas sete compostos, sendo o eugenol o composto principal. A composição em ácidos orgânicos deste extracto foi determinada por HPLC/UV e os ácidos oxálico, aconítico, cítrico, pirúvico, málico, chiquímico, acético e fumárico foram descritos pela primeira vez. O extracto aquoso também revelou capacidade para inibir a acetilcolinesterase de modo dependente da concentração.
Piper betle L., popularly known as “Paan”, is a species widely growing in South East Asia, where its leaves are economically and medicinally important. In order to screen the highest possible number of volatile and semi-volatile components, the leaves were subjected to headspace solid-phase microextraction (HS-SPME), hydrodistillation and Soxhlet extraction, prior to their analysis by GC/MS, which allowed the identification of 50 compounds, distributed by several chemical classes, 23 of them described for the first time. The different techniques lead to distinct compounds' extraction, with HS-SPME extracting highest amounts and providing the most complete profile. Within this procedure, best results were obtaine using Divinylbenzene/Polydimethylsiloxane (DVB/PDMS) fibre. Considering the use of the species as masticator, an aqueous extract was also analysed, in which only seven compounds were characterize, being eugenol the main one. The organic acids composition of this extract was determine by HPLC/UV and oxalic, aconitic, citric, pyruvic, malic, shikimic, acetic and fumaric acids are reported for the first time in this species. The aqueous extract also displayed AChE inhibitory capacity, in a concentration-dependent way.

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Belo, Cristóvão Ramiro. "Bétele (Piper Betle Linn): Análise de Metabolitos e acção sobre a Acetilcolinesterase." Master's thesis, Faculdade de Farmácia da Universidade do Porto, 2009. http://hdl.handle.net/10216/20777.

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Ananieva, V. V., S. О. Petrov, and D. S. Goloborodko. "Search of new excipients in technology of farmaceutical drugs." Thesis, Національний технічний університет "Харківський політехнічний інститут", 2018. http://repository.kpi.kharkov.ua/handle/KhPI-Press/45931.

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Varvaštian, Samvel. "Nanomedicinos teisinis reglamentavimas: ES ir JAV požiūris." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130205_094831-00731.

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Magistro baigiamajame darbe yra nagrinėjamas dabartinis nanomedicinos teisinis reglamentavimas ES ir JAV. Ši tema Lietuvoje iki šiol dar nebuvo tyrinėjimų objektu. Pirmoji darbo dalis supažindina skaitytoją su nanomedicina bei su ja susijusių sąvokų problematiką. Antroji dalis atskleidžia nanomedicinos teisinio reglamentavimo prielaidas ES, o trečioji dalis – JAV. Be to, atsižvelgiant į gautus rezultatus, yra įvertinamos galimos nanomedicinos teisinio reglamentavimo perspektyvos ateityje. Darbe plačiai analizuojami atitinkami pasirinktų tarptautinės teisės subjektų teisės aktai bei specialioji teisinė literatūra (įvairių institucijų dokumentai, teisės mokslininkų darbai) bei tam tikra mokslinė-techninė literatūra (įvairių institucijų ir organizacijų ataskaitos ir tyrimai, mokslininkų tyrimai).
The master thesis researches the current regulation of nanomedicine in the EU and the US. Until now, this topic has not yet been researched in Lithuania. In the first part of the thesis nanomedicine and the problem of nanomedicine-related definitions are introduced to the reader. The second part reveals the basis of the regulation of nanomedicine in the EU, and the third part – in the US. Furthermore, considering the achieved results, the perspective of the future regulation of nanomedicine is assessed. The thesis extensively analyses the legal acts of the chosen subjects of international law and specific legal literature (documents of various institutions, works of law scholars) as well as some scientific-technical literature (reports and researches of various institutions and organizations, scientists’ researches).

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Davies, Rachel A. "Structure-Activity Relationship Studies of Synthetic Cathinones and Related Agents." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5953.

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Synthetic cathinones and related agents represent an international drug abuse problem, and at the same time an important class of clinically useful compounds. Structure-activity relationship studies are needed to elucidate molecular features underlying the pharmacology of these agents. Illicit methcathinone (i.e., MCAT), the prototype of the synthetic cathinone class, exists as a racemic mixture. Though the differences in potency and target selectivity between the positional and optical isomers of synthetic cathinones and related agents have been demonstrated to have important implications for abuse and therapeutic potential, the two MCAT isomers have never been directly compared at their molecular targets: the monoamine transporters (MATs). Additionally, previous studies have found that the carbonyl oxygen atom can be replaced with a methoxy group, but this results in two chiral centers (i.e., four possible optical isomers for synthesis and evaluation). Here, the individual isomers of MCAT, their racemate, and achiral MCAT analogs were prepared where necessary, and examined in vitro and in silico at the MATs. All agents were active as substrates, with a rank order of potency suggesting that α-position chirality, in either configuration, is favored but not required, with the S(-) configuration slightly preferred. Either chiral center removal approach resulted in a reduction in potency, suggesting both favorable interactions with the α-methyl, and limited bulk tolerance. To further investigate this possibility, docking studies were conducted using homology models of the MATs. Common binding modes were identified that were similar to the binding mode of S(+)amphetamine co-crystallized at drosophila DAT. Taken together, these studies supported our conclusions, as steric hindrance was observed in the α-methyl region of the proposed binding site for the R(+)MCAT isomer. Inclusion of the original synthetic cathinones among Schedule I controlled substances has driven the clandestine development of a second generation of agents, resulting in an array of new synthetic cathinones diverse in structure and effect.Pyrrolidinophenones are a major constituent of second-generation bath salts. Little is known about their structure-activity relationships. Here, we have synthesized and examined a series of aryl-substituted pyrrolidinophenone analogs, as well as an achiral pyrrolidinophenone analog, utilizing novel synthetic chemistry and an innovative cell-based epifluorescence Ca2+ imaging technique. Herein, we evaluated the neurochemical properties of these novel compounds at the dopamine transporter (DAT), considered to exert a major role in actions of drugs of abuse. For future structure-activity relationship studies, additional analogs of synthetic cathinone-related agents were produced using novel synthetic approaches, including analogs and isomers of known amphetamine drugs of abuse. Finally, though much has been learned about the role of the dopamine and serotonin transporters in the mechanisms of action of synthetic cathinones, the role of the norepinephrine transporter is poorly understood. Homology models of the human norephinephrine transporter were built and docking studies conducted to inform the study of MAT ligand selectivity, activity, and binding. In conclusion, these studies represent progress towards the establishment of comprehensive structure-activity relationships for synthetic cathinones and related agents. Particular emphasis was placed on the SAR of the phenylalkylamine α-carbon in the synthetic cathinone context, and the role of the norepinephrine transporter in their activity.

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Viscardi, Ariel. "Avaliação da atividade antiproliferativa de extratos hidroalcoólicos de plantas em linhagens celulares humanas de câncer de mama, fígado e próstata." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-29082018-140818/.

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O câncer é uma das doenças que mais acometem a população no mundo. Dessa forma, estudar suas terapêuticas é importante para o entendimento dos mecanismos e alvos biológicos por detrás da doença. Apesar dos tratamentos convencionais apresentarem uma boa eficácia, eles também provocam respostas indesejadas, como danos moleculares, resistência de células neoplásicas e efeitos colaterais fortes, colaborando para uma maior taxa de reincidência de neoplasias e mortalidade de pacientes. Sendo assim, a busca por alternativas é um importante desafio da Ciência Moderna para aprimorar e/ou substituir esses tratamentos. As plantas medicinais, como alternativa, são o foco de muitos estudos voltados ao câncer. O objetivo do presente trabalho foi avaliar o efeito citotóxico de 59 extratos em linhagens celulares humanas de câncer de mama (MDA-MB-231 e MCF7), próstata (PC-3 e DU 145) e fígado (HepG2). Foi realizada, inicialmente, uma triagem dos extratos por MTT em duas diluições 100x e 1000x para análise da viabilidade celular desses extratos. No total, 35 extratos obtiveram uma resposta para, pelo menos, uma das linhagens de câncer. A próxima etapa envolveu estudar os extratos pré-seletivos na triagem através de curvas-resposta quantificando a seletividade desses extratos para cada linhagem testada. Para essa etapa, foram selecionados 31 extratos. No câncer de mama, para a linhagem MDA-MB-231 nove extratos foram seletivos, e para MCF7 foram seis extratos. No câncer de próstata, para a linhagem PC-3, quinze extratos foram seletivos, e para DU 145 dezesseis extratos foram seletivos, mostrando uma maior sensibilidade do câncer de próstata comparado ao câncer de mama e fígado (HepG2 - sete extratos seletivos) em relação aos extratos testados. De todos os resultados apresentados, algodão de seda (Calotropis procera), camomila (Matricaria chamomilla), casca de anta (Drimys winteri), erva de São Caetano (Momordica charantia L.), estigmas de milho (Zea mays), graviola (Annona muricata), ipê roxo (Tabebuia sp.), malva - folhas (Malva sylvestris) e unha de gato (Uncaria tomentosa) foram os extratos mais amplamente significativos atingindo as linhagens celulares apresentando altos índices de seletividade. Com a realização desse trabalho podemos concluir que os extratos apresentam atividade antiproliferativa e seus fitoquímicos podem ser utilizados no estudo de novos fitoterápicos. O próximo passo é elucidar os mecanismos moleculares onde eles atuam.
Cancer is one of the most common diseases overworld. Studying the therapeutics of it is important to understand the biological mechanisms and targets behind this disease. Although conventional treatments show a good outcome against some types of cancer, they also currently cause undesired responses, such as molecular damage, neoplastic cell resistance and strong side effects, increasing recurrence of neoplasms, metastasis formation, and patient mortality. Therefore, the search for new alternatives is a challenge for Modern Science to improve or replace conventional treatments. In view of their antiproliferative effects medicinal plants have become the focus of many cancer studies as an alternative. The aim of the present study was to evaluate the cytotoxic and antiproliferative effect of 59 plant extracts in human cancer cell lines as breast cancer (MDA-MB-231 and MCF7), prostate cancer (PC-3 and DU 145) and liver cancer (HepG2). Initially, the extracts were screened in two different dilutions 100x and 1000x by MTT to analyze the cellular viability and cytotoxicity effects of them. To 59 extracts analyzed, 35 were effective against at least one of the tested lineages. The next step involved studying those pre-selective extracts through response curves to quantify the selectivity of these extracts for each cell lineage tested. For this stage, 31 extracts were selected. In breast cancer, for MDA-MB-231, nine extracts were selective and for MCF7 were six extracts. In prostate cancer, for PC-3, fifteen extracts were selective and for DU 145 were sixteen extracts. For liver cancer (HepG2) only seven extracts were selective. Comparing all the cancer lineages we can see a greater sensitivity of prostate cancer lineages compared to breast cancer and liver cancer in response of these tested extracts. Of all the results presented, silk cotton (Calotropis procera), chamomile (Matricaria chamomilla), winter\'s bark (Drimys winteri), bitter melon (Momordica charantia L.), corn silk (Zea mays), graviola (Annona muricata), purple trumpet tree (Tabebuia sp.), malva - folhas (Malva sylvestris) e unha de gato (Uncaria tomentosa) silk cotton (Calotropis procera), chamomile (Matricaria chamomilla), graviola (Annona muricata) and mallow-leaves (Malva sylvestris) were the most effective extracts reaching different cell types and present high selectivity indices. With the accomplishment of this work we can conclude that the natural extracts of plants presented antiproliferative activity in cancer lines and their phytochemicals can be used to study new herbal medicines. The next step, then, is to understand the molecular mechanisms where they act.

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Alarcon, Gallegos Ligia Rocio. "Ethnobotany of the southern Basque country (Euskadi), Spain : the use of medicinal and foods plants and selection of species for further development of functional foods which increase perceived energy levels : identification and characterization of the effects of food substances which increase perceived energy levels." Thesis, University College London (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522821.

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Persson, Ingrid. "Plant-Derived Substances and Cardiovascular Diseases : Effects of Flavonoids, Terpenes and Sterols on Angiotensin-Converting Enzyme and Nitric Oxide." Doctoral thesis, Linköpings universitet, Hälsouniversitetet, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-45338.

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Diet has for many years been known to play a key role in the development of chronic diseases. There are clear associations between consumption of vegetables, fruits and berries, and risk of cardiovascular diseases, the number one cause of death in the world. To maintain homeostasis of the vascular wall the balance between angiotensin II, nitric oxide and reactive oxygen species is of great importance in order to affect the development of cardiovascular diseases. Angiotensin II, a potent vasoconstrictor causing cell growth and nitric oxide, a signalling molecule influencing the vascular system as a vasodilatator, inhibiting cell proliferation and reactive oxygen species, are linked together in the renin-angiotensin aldosteron system. Angiotensin-converting enzyme will as a key enzyme in the reninangiotensin aldosteron system convert angiotensin I to form angiotensin II and nitric oxide is known to inhibit angiotensin-converting enzyme and act as a scavenger of reactive oxygen species. Plant-derived substances as flavonoids, tocopherols and carotenoids are shown to have beneficial effects on the cardiovascular system due to their antioxidative effects. The aims of this study were to investigate beverages, dietary products, herbal medicinal plants, α-tocopherol, β-carotene, sterols and lipidowering drugs on angiotensin-converting enzyme activity and nitric oxide concentrations. This was done to investigate if the sole mechanism of plant-derived substances is their antioxidative properties and to investigate if there is any connection between effect and biosynthesis/structure of plant substances. The tested infusions and extracts containing high amounts of flavonoids, the flavonoids and β-carotene significantly inhibited angiotensin-converting enzyme activity in vitro. The other substances tested did not affect, or in some cases significantly increased, angiotensin-converting enzyme activity. The infusions and extracts containing high amounts of flavonoids, the flavonoids andβ-carotene showed an increase on nitric oxide concentrations in vitro. Oral intake of a single dose of Rooibos tea significantly inhibited angiotensin-converting enzyme activity. A significant inhibition of angiotensin-converting enzyme activity was seen with the green tea for the angiotensin-converting enzyme genotypes II and ID. A significant inhibition of angiotensin-converting enzyme activity was also seen with the Rooibos tea for the angiotensin-converting enzyme genotype II. Conclusion; flavonoids and β-carotene interact with the cardiovascular system in severalways, by reducing reactive oxygen species (as shown in several studies), increasing nitricoxide concentrations (as shown here and by others) and also by inhibiting angiotensinconvertingenzyme activity (as shown here). Infusions and extracts as tea containing highamounts of flavonoids function as angiotensin-converting enzyme inhibitors. Angiotensinconvertingenzyme contains two zink-dependent catalytic domains and angiotensinconvertingenzyme inhibitors are designed to bind to the Zn2+ at the active site. If theinhibitory mechanism of flavonoids on angiotensin-converting enzyme activity is due to theirability to bind to Zn2+ ions then it would be possible for the flavonoids to also inhibit otherzinc metallopeptidases, i.e. endothelin-converting enzyme, matrix metallopeptidases, neutralendopeptidase and maybe insulin-degrading enzyme, thereby exerting several additionalpositive effects on the cardiovascular system.
2009

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Houël, Emeline. "ETUDE DE SUBSTANCES BIOACTIVES ISSUES DE LA FLORE AMAZONIENNE Analyse de préparations phytothérapeutiques à base de Quassia amara L. (Simaroubaceae) et de Psidium acutangulum DC. (Myrtaceae) utilisées en Guyane française pour une indication antipaludique. Identification et analyse métabolomique d'huiles essentielles à activité antifongique." Phd thesis, Université des Antilles-Guyane, 2011. http://tel.archives-ouvertes.fr/tel-00718910.

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L'objectif du travail effectué était la recherche de nouvelles substances actives d'origine végétale, présentant soit une activité antiplasmodiale soit une activité antifongique. Cette étude a été menée suivant deux stratégies différentes: l'étude de remèdes traditionnels antipaludiques identifiés suite à des enquêtes ethnopharmacologiques, et la mise en évidence des propriétés antifongiques d'huiles essentielles grâce à une stratégie bioinspirée. La première partie du travail a permis de mettre en évidence le rôle d'un quassinoïde connu, la simalikalactone D, dans l'activité antipaludique d'une tisane de jeunes feuilles fraîches de Quassia amara L. (Simaroubaceae). Dans le cas de la décoction de rameaux de Psidium acutangulum DC. (Myrtaceae), c'est cette fois un mélange de flavonoïdes glycosylés qui est responsable de l'activité du remède. Dans le cadre de la recherche de nouvelles substances antifongiques, le criblage effectué a permis d'identifier de nombreuses huiles essentielles présentant des activités intéressantes, validant ainsi la démarche bioinspirée retenue dans ce cas. L'huile essentielle d'Otacanthus azureus (Linden) Ronse a en particulier démontré une activité remarquable, à la fois seule et en combinaison avec des antifongiques azolés. Enfin, l'étude métabolomique de la composition des huiles essentielles a permis de mettre au point un outil pouvant orienter la sélection des huiles en fonction des données obtenues en GC/MS dans l'optique de la recherche de nouvelles substances antifongiques. Ce travail démontre donc la validité des stratégies retenues - ethnopharmacologie et bioinspiration - dans la recherche de nouvelles substances bioactives.

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Davies, Christopher S. "The role of oxygen-dependent substances in exercise." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4273/.

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This thesis investigated the role of O\(_2\)-dependent substances in mediating the vasodilatation seen following exercise (post-exercise hyperaemia) and in fatigue development. Additionally we compared young and old subjects to investigate the effects of ageing in both of these phenomena. Breathing supplementary 40% O\(_2\) during handgrip exercise at 50% of maximum voluntary contraction had no effect of the magnitude of post-exercise hyperaemia compared to air breathing control. Furthermore, aspirin administration did not alter magnitude of post-exercise hyperaemia or the levels of prostaglandin E metabolites assayed from the forearm venous efflux. Similarly the magnitude of post-exercise hyperaemia was not affected by aminophylline administration. Collectively these suggest that prostaglandins and adenosine are not obligatory mediators of post-exercise hyperaemia. Supplementary O\(_2\) breathed during recovery had no effect on fatigue in a second bout of exercise or any of the substances proposed to mediate fatigue, in young subjects. We demonstrated that older subjects showed no changes in the magnitude of post-exercise hyperaemia, but they were more fatigue resistant. There was no O\(_2\)-dependence of either post-exercise hyperaemia or fatigue in older subjects. In conclusion, we have found no evidence of O\(_2\)-dependent mediators in either post-exercise hyperaemia or fatigue.

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Книги з теми "Medicinal substances"

O'Connor, Peter J. Accidental poisoning of preschool children from medicinal substances, Australia. Canberra: Australian Institute of Health and Welfare, 2001.

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Medicinal substances in Jerusalem from early times to the present day. Oxford: Archaeopress, 2003.

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Barceloux, Donald G. Medical toxicology of natural substances: Foods, fungi, medicinal herbs, plants, and venomous animals. Hoboken, N.J: Wiley-Interscience, 2008.

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Law on poisons, medicines, and related substances. 2nd ed. Beckenham, Kent, England: Ravenswood Publications, 1986.

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Bueno, Santiago Delgado, José Manuel Torrecilla Jiménez, and José Cabrera Forneiro. Medicina legal en drogodependencias. Madrid: Comunidad de Madrid, Agencia Antidroga, Consejería de Sanidad y Servicios Sociales, 1999.

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Seelig, Bruce Duane. Water resource impacts: From medicines and other biologically active substances. Fargo, N.D: NDSU Extension service, 2005.

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García-Alejo, Rafael Huertas. El delincuente y su patología: Medicina, crimen y sociedad en el positivismo Argentino. Madrid: Consejo Superior de Investigaciones Científicas, 1991.

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Albee, Sarah. Poison: Deadly deeds, perilous professions, and murderous medicines. New York: Crown Children's Books, 2017.

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World Health Organization (WHO). Ensuring balance in national policies on controlled substances: Guidance for availability and accessibility of controlled medicines. Geneva: World Health Organization, 2011.

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Seibert, Philip. Be safe!: Manager's guide to hazardous substances. Lakewood, Colo: American Animal Hospital Association Press, 2008.

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Частини книг з теми "Medicinal substances"

Kinghorn, A. Douglas, Leng Chee Chang, and Baoliang Cui. "Bioactive Substances from Medicinal Plants." In ACS Symposium Series, 102–14. Washington, DC: American Chemical Society, 2000. http://dx.doi.org/10.1021/bk-2001-0774.ch009.

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Vlietinck, A. J., L. A. C. Pieters, and D. A. Vander Berghe. "Bioassay-Guided Isolation and Structure Elucidation of Pharmacologically Active Plant Substances." In Phytochemistry of Medicinal Plants, 113–35. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-1778-2_6.

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Takeuchi, Hiroko, and Takashi Kurahashi. "Olfactory Transduction Channels and Their Modulation by Varieties of Volatile Substances." In Topics in Medicinal Chemistry, 115–49. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/7355_2015_100.

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Rubatzky, Vincent E., and Mas Yamaguchi. "Toxic Substances and Some Folk and Medicinal Uses of Vegetables." In World Vegetables, 42–55. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-6015-9_5.

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Pengelly, Andrew. "Resins and cannabinoids." In The constituents of medicinal plants, 112–22. 3rd ed. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789243079.0007.

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Abstract This chapter provides an overview of resins, which are solid, brittle substances secreted by plants into special ducts, often as a response to damage to the plant by wounding, wind or insect damage. Some major resin and oleo-gum-resin containing plants, such as myrrh, ginger, Capsicum sp. and Podophyllum sp., among others, are presented along with their pharmacological properties. Information on the structures, biosynthesis and medicinal properties of cannabinoids, which are derived from Cannabis sativa, are highlighted.

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Salamat, Julia M., Kodye L. Abbott, Kristina S. Gill, Patrick C. Flannery, Vinicia C. Biancardi, Dawn M. Boothe, Chen-Che J. Huang, et al. "Insights into Mechanisms and Models for Studying Neurological Adverse Events Mediated by Pharmacokinetic Interactions between Clinical Drugs and Illicit Substances of Herbal and Fungal Origin." In Medicinal Herbs and Fungi, 137–58. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-4141-8_5.

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Sułkowska-Ziaja, Katarzyna, Agata Fijałkowska, and Bożena Muszyńska. "Selected Species of Medicinal/Arboreal Mushrooms as a Source of Substances with Antioxidant Properties." In Plant Antioxidants and Health, 1–27. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-45299-5_38-1.

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Sułkowska-Ziaja, Katarzyna, Agata Fijałkowska, and Bożena Muszyńska. "Selected Species of Medicinal/Arboreal Mushrooms as a Source of Substances with Antioxidant Properties." In Plant Antioxidants and Health, 95–121. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-78160-6_38.

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Nahler, Gerhard. "substance." In Dictionary of Pharmaceutical Medicine, 178. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-89836-9_1360.

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Fair, Nadene C., and Howard S. Smith. "Substance Abuse." In Perioperative Medicine, 381–93. London: Springer London, 2011. http://dx.doi.org/10.1007/978-0-85729-498-2_31.

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Тези доповідей конференцій з теми "Medicinal substances"

Aires, Ana, Diana Gomes Moreira, Maria de Lourdes Pereira, and Miguel Oliveira. "Effect of cytostatic substances in zebrafish embryos." In 6th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/ecmc2020-07500.

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Lengers, Isabelle, Zoya Orlando, Matthias Melzig, Armin Buschauer, Andreas Hensel, and Joachim Jose. "Inhibition of the cancer target human hyaluronidase Hyal‑1 by natural substances." In 1st International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2015. http://dx.doi.org/10.3390/ecmc-1-a014.

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Belashova, O. V., A. V. Zaushintsena, and N. V. Fotina. "BIOTECHNOLOGICAL PROCESS OF CREATING FUNCTIONAL DAIRY PRODUCT ENRICHED WITH THE EXTRACT OF SCUTELLARIA GALERICULATA L." In STATE AND DEVELOPMENT PROSPECTS OF AGRIBUSINESS Volume 2. DSTU-Print, 2020. http://dx.doi.org/10.23947/interagro.2020.2.669-673.

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One of the ways to eliminate population diseases and increase the body is resistance to adverse environmental factors is the systematic use of functional food products enriched with a complex of biologically active substances with a wide range of therapeutic effects. The creation of a new, unique functional dairy product was preceded by long-term comparative biochemical studies of Scutellaria baicalensis Georgi and Scutellaria galericulata L. In the grass and roots, biologically active substances of a phenolic nature, such as baicalin, vogonin, scutellarin, etc., were found useful for medicinal purposes. The use of extracts from the of Scutellaria galericulata L. in the development of a functional product based on sour-milk fractions made it possible to obtain curd mass enriched with the biologically active substance of this plant. The functional product meets the organoleptic, physico-chemical, tasting requirements for new functional products and is recommended for introduction into the diet of different population groups by age and functional activity.

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"Development of a test system for evaluating the antiglycative effect of bioactive substances of medicinal plants." In SYSTEMS BIOLOGY AND BIOINFORMATICS (SBB-2020). Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences., 2020. http://dx.doi.org/10.18699/sbb-2020-37.

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Bybyk, Elena, and Darya Vaylenko. "Research on Prospective Pharmacorrection Medications for First-degree Obesity Treatment among Non-natural Substances Containing Chalcogenamido Groups." In 3rd International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2017. http://dx.doi.org/10.3390/ecmc-3-04683.

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Merki, R., A. Schönborn, and E. Wolfram. "Screening for active substances with TLC bioautography: challenges with artefacts." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400085.

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Vatsaev, Sh V., A. M. Plieva, and A. Sh Abdulkhazhieva. "The role of medicinal substances that restore acid-base balance in the body of animals with nodular dermatitis of cattle." In I INTERNATIONAL CONFERENCE ASE-I - 2021: APPLIED SCIENCE AND ENGINEERING: ASE-I - 2021. AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0075861.

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Solnier, J., S. Bhakta, and F. Bucar. "Impact of herbal substances on efflux pumps in bacterial and human cells." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400401.

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Mladenovic, Jelena, Veronika Markovic, Ljiljana Boskovic-Rakocevic, Milena Đuric, and Nenad Pavlovic. "ISPITIVANJE EKSTRAKATA ORIGANA DOBIJENIH RAZLIČITIM METODAMA." In XXVI savetovanje o biotehnologiji sa međunarodnim učešćem. University of Kragujevac, Faculty of Agronomy, 2021. http://dx.doi.org/10.46793/sbt26.407m.

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Oregano is used in the production of specific aromatic cheeses, meat products and dough dishes, for the production of medicinal preparations, fragrant soaps, colognes and perfumes. Special interest in oregano in recent years is related to the results of a study of its biological activities, which indicate a wide range of antibacterial, fungicidal, antiviral and antioxidant properties. The subject of this paper is the examination of extracts of plant species of oregano (Origanum vulgare), with the aim of determining the method that is most popular for extracting this plant species and which gives the best yields of extracts. The content of extracted substances in each extract, the content of vitamin C as well as the content of organic acids were determined.

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Babich, O., V. Larina, A. Bahtiyarova, and A. Popov. "Selection of parameters for the isolation of individual biologically active substances of medicinal plants of the Kaliningrad region (eryngium, larkspur and yarrow)." In ChemBioSeasons 2022. Kemerovo State University, 2022. http://dx.doi.org/10.21603/chembioseasons2022-4.

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