Готові списки джерел за темами / Marginal approach

Добірка наукової літератури з теми "Marginal approach"

Автор: Grafiati
Опубліковано: 30 травня 2022
Оновлено: 31 травня 2022

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Статті в журналах з теми "Marginal approach"

1

Carfì, David, and Alessia Donato. "Cournot-Bayesian General Equilibrium: A Radon Measure Approach." Mathematics 7, no. 1 (December 22, 2018): 10. http://dx.doi.org/10.3390/math7010010.

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In this paper, we consider a Cournot duopoly, in which any firm does not know the marginal costs of production of the other player, as a Bayesian game. In our game, the marginal costs depend on two infinite continuous sets of states of the world. We shall study, before the general case, an intermediate case in which only one player, the second one, shows infinitely many types. Then, we shall generalize to the case in which both players show infinitely many types depending on the marginal costs, where the marginal costs are given by the nature and each actual marginal cost is known only by the respective player. We find, in both cases, the general Nash equilibrium.
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2

Ekvall, Tomas. "Comment on the marginal approach to allocation." Journal of Cleaner Production 7, no. 6 (December 1999): 465–66. http://dx.doi.org/10.1016/s0959-6526(99)00158-4.

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3

Dubey, R., L. W. Wang, E. C. Figueira, S. Amjadi, T. M. Brown, N. M. Younan, G. Wilcsek, and I. C. Francis. "Management of marginal chalazia: a surgical approach." British Journal of Ophthalmology 95, no. 4 (August 5, 2009): 590. http://dx.doi.org/10.1136/bjo.2008.146704.

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4

Frenk, J. B. G., R. Dekker, and M. J. Kleijn. "On the Marginal Cost Approach in Maintenance." Journal of Optimization Theory and Applications 94, no. 3 (September 1997): 771–81. http://dx.doi.org/10.1023/a:1022621621633.

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5

Araujo, A., H. Moreira, and S. Vieira. "The marginal tariff approach without single-crossing." Journal of Mathematical Economics 61 (December 2015): 166–84. http://dx.doi.org/10.1016/j.jmateco.2015.06.020.

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6

Yung-Chang, Wang. "A conjectural variation approach to vertical integration in agricultural cooperatives." Agricultural Economics (Zemědělská ekonomika) 63, No. 5 (May 9, 2017): 228–33. http://dx.doi.org/10.17221/202/2016-agricecon.

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Under the assumption that agricultural cooperative is a form of vertical integration, this paper, using conjectural variations, solves the profit-maximizing problem faced by the members in the multi-plant firm model in which they are vertically integrated with the agricultural cooperative. The average principle, the marginal principle, and the linear combination principle are derived for the competitive behaviour, collusive behaviour, and Cournot behaviour, respectively. The Nash equilibrium and economic efficiency in the cooperative system are then discussed. Finally, the model is numerically solved in an illustration. The marginal principle ensures the cooperative system to remain socially optimal in the competitive market.
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7

Lasserre, Jean B. "A “Joint+Marginal” Approach to Parametric Polynomial Optimization." SIAM Journal on Optimization 20, no. 4 (January 2010): 1995–2022. http://dx.doi.org/10.1137/090759240.

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8

Parisi, Maria A. "Marginal cost based seismic decision: A probabilistic approach." Earthquake Engineering & Structural Dynamics 15, no. 3 (April 1987): 367–77. http://dx.doi.org/10.1002/eqe.4290150306.

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9

Bertolino, Francesco, Ludovico Piccinato, and Walter Racugno. "A Marginal Likelihood Approach to Analysis of Variance." Statistician 39, no. 4 (1990): 415. http://dx.doi.org/10.2307/2349085.

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10

XU, DONG, DACHENG TAO, XUELONG LI, and SHUICHENG YAN. "FACE RECOGNITION — A GENERALIZED MARGINAL FISHER ANALYSIS APPROACH." International Journal of Image and Graphics 07, no. 03 (July 2007): 583–91. http://dx.doi.org/10.1142/s0219467807002817.

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In this paper, we propose a new supervised learning algorithm, which is named the Generalized Marginal Fisher Analysis (GMFA), to utilize the advantages of the Marginal Fisher Analysis (MFA) and the Generalized Singular Value Decomposition (GSVD) techniques for face recognition. The experimental results on several standard face databases demonstrate that GMFA outperforms LDA/Fisherface, LDA/GSVD and MFA.
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Дисертації з теми "Marginal approach"

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Moolman, Christina Elizabeth. "Modeling the marginal revenue of water in selected agricultural commodities a panel data approach /." Diss., Pretoria : [s.n.], 2005. http://upetd.up.ac.za/thesis/available/etd-09162005-094852.

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Adam, William George. "The relationship between subglacial processes, basal ice characteristics and ice marginal moraines : a sedimentological approach." Thesis, Keele University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518415.

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Davis, Heather Monique. "Gender, crime and marginal youth, assessing an integrated theory approach to studying economic survival strategies of street youth." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ55666.pdf.

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Zhao, Zuoxiang. "A by-production approach to studying environment-constrained technical and allocative inefficiencies and measuring marginal abatement costs : the case of China's provinces." Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/26499.

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This thesis employs the by-production approach to modelling pollution generating technologies to investigate production and environmental efficiencies, design consumption increasing and emission non-increasing input policy reforms, and derive a measure of marginal abatement costs in the case of China. The second chapter introduces by-production approach to modelling the pollution generating technologies. It decomposes a general pollution generating technology as classical intended production technology and nature’s residual-generation mechanism. In this chapter, some production and environmental efficiency indexes will be extended and applied under by-production approach to study China’s regional technical efficiency incorporated emission generation. According to our estimation results, some reasons analysis and policy implementation suggestions are given. The third chapter co-authored with Professor Sushama Murty proposes a model that gives a key role to the energy sector, and gives a theoretical characterisation for the existence of feasible, consumption-increasing, and emission-non increasing input policy reforms at the status-quo of a national or a sub-national economic unit. A methodology is developed to empirically test for the existence of such efficiency-improving reforms. Formulae to compute the optimal efficiency-increasing reform and a measure of marginal abatement cost (MAC) based on local policy reforms using data available at the status-quo are derived. The fourth chapter co-authored with Professor Sushama Murty implements the methodology developed in the third chapter to test the existence and to study the structure of efficiency-improving reforms using data on thirty provinces in China. A new class of limitational variable elasticity of substitution (LVES) production functions for specifying technologies of the energy-using and energy-generating sectors is introduced and two such production functions are estimated along with the conventional Cobb Douglas and CES production functions. MACs and the optimal efficiency-improving reforms are found to be sensitive to the choice of the production functions employed. There is a huge variation in MACs across provinces. The optimal efficiency-improving reform encourages a substitution from coal-fired electricity generation to gas-fired electricity and renewable energy generation for all provinces. The fifth chapter reviews China’s regional variations in electricity generation, primary energy usage, and forest cover. To better understand the China’s carbon emission control policies, we also briefly introduce the carbon emission scheme implementation. Based on these information, we incorporate the efficiency-improving reforms and MACs estimated in the fourth chapter to analyse the direction of input resources reallocation and give further recommendations for each province.
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Wulff, Thorben Verfasser], Antje [Akademischer Betreuer] [Gutachter] [Boetius, and Oliver [Gutachter] Zielinski. "Physics and Ecology in the Marginal Ice Zone of the Fram Strait : a Robotic Approach / Thorben Wulff ; Gutachter: Antje Boetius, Oliver Zielinski ; Betreuer: Antje Boetius." Bremen : Staats- und Universitätsbibliothek Bremen, 2015. http://d-nb.info/1119290643/34.

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Lybrand, Blythe, Ginette Blackhart, Amanda Parish, and Hannah Lowe. "Investigating the Misrepresentation of Statistical Significance in Empirical Articles." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/honors/646.

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In an attempt to preserve research integrity, the aim of this study is to examine how often statistical results are being misrepresented in empirical studies by using terms such as “marginally significant,” “approached significance,” or “trend toward significance” when interpreting findings. The use of these terms gives ambiguous significance to results that are in fact nonsignificant, which threatens future research by contributing to issues such as the replication crisis. For this study, data were coded from 437 empirical articles published online in The Journal of Personality and Social Psychology (JPSP) over a 4-year period between 2017 and 2020. According to our findings, although misrepresentation of statistical results are prevalent within JPSP articles, rates decreased significantly over the four-year time period examined. Additionally, as the number of studies published in JPSP increased each year during the four-year period examined, there may be a potential rise in representatively sound studies and decrease of misrepresentation within this discipline.
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Zubo, Rana H. A. "Distribution Network Operation with High Penetration of Renewable Energy Sources. Joint Active/Reactive Power Procurement: A Market-Based Approach for Operation of Distribution Network." Thesis, University of Bradford, 2019. http://hdl.handle.net/10454/18267.

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Distributed generators (DGs) are proposed as a possible solution to supply economic and reliable electricity to customers. It is adapted to overcome the challenges that are characterized by centralized generation such as transmission and distribution losses, high cost of fossil fuels and environmental damage. This work presents the basic principles of integrating renewable DGs in low voltage distribution networks and particularly focuses on the operation of DG installations and their impacts on active and reactive power. In this thesis, a novel technique that applies the stochastic approach for the operation of distribution networks with considering active network management (ANM) schemes and demand response (DR) within a joint active and reactive distribution market environment is proposed. The projected model is maximized based on social welfare (SW) using market-based joint active and reactive optimal power flow (OPF). The intermittent behaviour of renewable sources (such as solar irradiance and wind speed) and the load demands are modelled through Scenario-Tree technique. The distributed network frame is recast using mixed-integer linear programming (MILP) that is solved by using the GAMS software and then the obtained results are being analysed and discussed. In addition, the impact of wind and solar power penetration on the active and reactive distribution locational prices (D-LMPs) within the distribution market environment is explored in terms of the maximization of SW considering the uncertainty related to solar irradiance, wind speed and load demands. Finally, a realistic case study (16-bus UK generic medium voltage distribution system) is used to demonstrate the effectiveness of the proposed method. Results show that ANM schemes and DR integration lead to an increase in the social welfare and total dispatched active and reactive power and consequently decrease in active and reactive D-LMPs.
Ministry of Higher Education and Scientific Research - Iraq
The selected author's publications, the published versions of which were attached at the end of the thesis, have been removed due to copyright.
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8

Parker, Jeffrey. "Palatalization and Utilization of Contrast: An Information-theoretic Investigation of Palatalization in Russian." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1373292844.

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9

Welschinger, Rémy Léon Victor. "Les Jenischs d'Alsace : approche d'une culture nomade marginale." Université Marc Bloch (Strasbourg) (1971-2008), 2007. http://www.theses.fr/2007STR20018.

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La présente thèse propose une approche générale de la communauté des Jenischs d'Alsace, une communauté marginalisée, mais qui n'a à notre connaissance, pas encore fait l'objet d'une étude approfondie. Cette population, vraisemblablement de souche germanique, mais dont l'origine n'est pas déterminée de manière certaine, a pratiqué le nomadisme jusqu'à la seconde guerre mondiale, ainsi que des métiers particuliers, dont ceux de vannier ou de rémouleur. Bien que sédentarisés pour la majorité d'entre eux, les Jenischs ont su toutefois conserver des caractéristiques propres : la pratique d'une langue particulière, des activités professionnelles spécifiques, une organisation en clans familiaux et d'une manière générale, un rapport au monde qui demeure basé sur le nomadisme et les distingue et marginalise fortement. A travers l'étude de ces différentes caractéristiques, nous avons tenté de comprendre la relation heurtée que la société jenische entretient avec la population environnante
The present thesis proposes a general approach of the community of Jenischs of Alsace, a marginalized wandering culture, located weIl, but which to our knowledge was not the subject of a thorough study yet. This population, probably of Germanic stock, but whose origin is not given in an unquestionable way, practised the nomadism to the second world war, as weIl as particular trades, of which those of basket maker or grinder. Although sedentarized for the majority of them, Jenischs knew however to preserve particular characteristics : the practice of a particular language, specific occupations, an organization as family clans and generally, a report in the world which remains based on the nomadism and strongly distinguishes them and marginalizes. Through the study of these various characteristics, we tried to understand the run up against relation that the society jenische maintains with the surrounding population
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10

Miller, Ryan. "Marginal false discovery rate approaches to inference on penalized regression models." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6474.

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Data containing large number of variables is becoming increasingly more common and sparsity inducing penalized regression methods, such the lasso, have become a popular analysis tool for these datasets due to their ability to naturally perform variable selection. However, quantifying the importance of the variables selected by these models is a difficult task. These difficulties are compounded by the tendency for the most predictive models, for example those which were chosen using procedures like cross-validation, to include substantial amounts of noise variables with no real relationship with the outcome. To address the task of performing inference on penalized regression models, this thesis proposes false discovery rate approaches for a broad class of penalized regression models. This work includes the development of an upper bound for the number of noise variables in a model, as well as local false discovery rate approaches that quantify the likelihood of each individual selection being a false discovery. These methods are applicable to a wide range of penalties, such as the lasso, elastic net, SCAD, and MCP; a wide range of models, including linear regression, generalized linear models, and Cox proportional hazards models; and are also extended to the group regression setting under the group lasso penalty. In addition to studying these methods using numerous simulation studies, the practical utility of these methods is demonstrated using real data from several high-dimensional genome wide association studies.
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Книги з теми "Marginal approach"

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Mariana, Mondini, Muñoz Sebastián, and Wickler Stephen, eds. Colonisation, migration and marginal areas: A zooarchaeological approach. Oxford: Oxbow, 2004.

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2

Hart, Robert A. The employment and hours effects of a marginal employment subsidy: A microeconomic approach. Stirling: University of Stirling, 1986.

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3

Twaddle, Sara. Improving gynaecology services within existing resources: A programme budgeting and marginal analysis approach. Glasgow: Scottish Forum for Public Health Medicine, 1994.

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4

Jacobi, Lena. Does marginal employment substitute regular employment?: A heterogeneous dynamic labor demand approach for Germany. Essen: RWI, 2008.

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5

Marginal cost in the new economy: A proposal for a uniform approach to policy evaluations. Armonk, NY: M.E. Sharpe, 2003.

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6

Gupta, Manish. Estimation of marginal abatement costs for undesirable outputs in India's power generation sector: An output distance function approach. New Delhi: Publications Unit, National Institute of Public Finance and Policy, 2005.

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7

Diarmuid, Ó Cearbhaill, and University College Galway, eds. New approaches to the development of marginal regions: 8th International Seminar on Marginal Regions, in Association with University College, Galway. [Galway: University College, Galway?], 1986.

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8

(Editor), Mariana Mondini, Sebastian Munoz (Editor), and Stephen Wickler (Editor), eds. Colonization, Migration, and Marginal Areas: A Zooarchaeological Approach (Proceedings of the 9th ICAZ Conference). David Brown Book Company, 2004.

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9

Conkling, Roger L. Marginal Cost in the New Economy: A Proposal for a Uniform Approach to Policy Evaluations. M.E. Sharpe, 2004.

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10

Conkling, Roger L. Marginal Cost in the New Economy: A Proposal for a Uniform Approach to Policy Evaluations. Routledge, 2015. http://dx.doi.org/10.4324/9781315702568.

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Частини книг з теми "Marginal approach"

1

Petri, Fabio. "Introduction to the Marginal Approach." In Microeconomics for the Critical Mind, 153–245. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-62070-7_3.

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2

Lasserre, Jean B. "A “Joint+Marginal” Approach in Optimization." In Handbook on Semidefinite, Conic and Polynomial Optimization, 271–95. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-0769-0_10.

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3

Kim, Peter Chanwoo, and Dae Hwan Park. "External Marginal Approach Rhinoplasty (EMA Rhinoplasty)." In Advanced Aesthetic Rhinoplasty, 241–94. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-28053-5_21.

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4

Berg, Menachem P. "Economics Oriented Maintenance Analysis and the Marginal Cost Approach." In Reliability and Maintenance of Complex Systems, 189–205. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-662-03274-9_12.

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Phillips, Robert L. "A marginal-value approach to airline origin & destination revenue management." In System Modelling and Optimization, 905–17. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/bfb0035540.

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Zhu, X. G., T. G. Chang, Q. F. Song, J. Finnan, S. Barth, L. M. Mårtensson, and M. B. Jones. "A Systems Approach Guiding Future Biomass Crop Development on Marginal Land." In Perennial Biomass Crops for a Resource-Constrained World, 209–24. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-44530-4_18.

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Cabitza, Federico, Angela Locoro, and Aurelio Ravarini. "Reporting Some Marginal Discourses to Root a De-design Approach in IS Development." In Exploring Digital Ecosystems, 273–88. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-23665-6_20.

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Loose, Dirk A. "How to approach treatment of marginal vein combined with deep vein hypoplasia/aplasia?" In Vascular Malformations, 183–86. Boca Raton : CRC Press, [2020]: CRC Press, 2019. http://dx.doi.org/10.1201/9780367255343-41.

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Lee, Seunghak, Aurélie Lozano, Prabhanjan Kambadur, and Eric P. Xing. "An Efficient Nonlinear Regression Approach for Genome-Wide Detection of Marginal and Interacting Genetic Variations." In Lecture Notes in Computer Science, 167–87. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16706-0_17.

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Li, H. K., X. J. Ma, Q. M. Ren, and J. L. Zhao. "Recognition on Rolling Bearing’s Condition of Grinding Machine by Using a Novel Approach-Wavelet Hilbert Marginal Spectrum." In Advances in Abrasive Technology IX, 773–78. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-416-2.773.

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Тези доповідей конференцій з теми "Marginal approach"

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Matsumoto, T. "Marginal Likelihood Change Detection: Particle Filter Approach." In BAYESIAN INFERENCE AND MAXIMUM ENTROPY METHODS IN SCIENCE AND ENGINEERING: 25th International Workshop on Bayesian Inference and Maximum Entropy Methods in Science and Engineering. AIP, 2005. http://dx.doi.org/10.1063/1.2149788.

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Braun, Stefan, Stefan Scheichl, and Alfred Kluwick. "Adjoint operator approach in marginal separation theory." In 11TH INTERNATIONAL CONFERENCE OF NUMERICAL ANALYSIS AND APPLIED MATHEMATICS 2013: ICNAAM 2013. AIP, 2013. http://dx.doi.org/10.1063/1.4825471.

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Pernsantia, S., P. Siriyoot, A. Suphawajruksakul, and S. Thanudamrong. "CLUSTER DEVELOPMENT CONCEPT: NEW APPROACH FOR MALAYSIA MARGINAL FIELDS." In APGCE 2019. European Association of Geoscientists & Engineers, 2019. http://dx.doi.org/10.3997/2214-4609.201903423.

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Guliyev, R. A. "An approach to issue of diagnosing marginal oil wells." In 2013 Joint IFSA World Congress and NAFIPS Annual Meeting (IFSA/NAFIPS). IEEE, 2013. http://dx.doi.org/10.1109/ifsa-nafips.2013.6608624.

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Clark, T. J., and H. H. Hanafy. "An Innovative Secondary Recovery Approach for a Marginal Reservoir." In Middle East Oil Show. Society of Petroleum Engineers, 1995. http://dx.doi.org/10.2118/29779-ms.

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Abili, N., O. Udofot, and Fuat Kara. "Subsea Processing: A Holistic Approach to Marginal Field Developments." In Offshore Technology Conference. Offshore Technology Conference, 2012. http://dx.doi.org/10.4043/22860-ms.

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Weatherl, Michael H., and Jack Hardy. "A New Approach to Sidetrack Drilling of Marginal Wells Offshore." In SPE/IADC Drilling Conference. Society of Petroleum Engineers, 2001. http://dx.doi.org/10.2118/67827-ms.

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Gomathi, M., and Anil Kumar. "An Integrated Approach for Development of KG Offshore Marginal Fields." In SPE Oil and Gas India Conference and Exhibition. Society of Petroleum Engineers, 2010. http://dx.doi.org/10.2118/129016-ms.

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Millheim, Keith K., Serge Rueff, Thomas Tygesen, and Mats Rosengren. "A New Approach For Making Deep Water Marginal Fields Economical." In SPE Asia Pacific Oil and Gas Conference and Exhibition. Society of Petroleum Engineers, 2012. http://dx.doi.org/10.2118/158783-ms.

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Ji, Yuting, Jinsub Kim, Robert J. Thomas, and Lang Tong. "Forecasting real-time locational marginal price: A state space approach." In 2013 Asilomar Conference on Signals, Systems and Computers. IEEE, 2013. http://dx.doi.org/10.1109/acssc.2013.6810300.

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Звіти організацій з теми "Marginal approach"

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Research Institute (IFPRI), International Food Policy. The (marginal) cost of technology adoption: A cost-effectiveness analysis of Digital Green’s video-mediated agricultural extension approach in Ethiopia. Washington, DC: International Food Policy Research Institute, 2019. http://dx.doi.org/10.2499/p15738coll2.133250.

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Gelfand, Alan E., and Adrian F. Smith. Sampling Based Approaches to Calculating Marginal Densities. Fort Belvoir, VA: Defense Technical Information Center, April 1989. http://dx.doi.org/10.21236/ada208388.

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García-Dory, Fernando, Ella Houzer, and Ian Scoones. Livestock and Climate Justice: Challenging Mainstream Policy Narratives. Institute of Development Studies (IDS), October 2021. http://dx.doi.org/10.19088/1968-2021.128.

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Анотація:
In discussions around food systems and the climate, livestock is often painted as the villain. While some livestock production in some places contributes significantly to climate change, this is not universally the case. This article focuses on pastoral production systems – extensive, often mobile systems using marginal rangelands across around half of the world’s surface, involving many millions of people. By examining the assumptions behind standard calculations of greenhouse gas emissions, a systematic bias against pastoralism is revealed. Many policy and campaign stances fail to discriminate between different material conditions of production, lumping all livestock systems together. Injustices arise through the framing of debates and policy knowledge; through procedures that exclude certain people and perspectives; and through the distributional consequences of policies. In all cases, extensive livestock keepers lose out. In reflecting on the implications for European pastoralism, an alternative approach is explored where pastoralists’ knowledge, practices and organisations take centre‑stage.
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Zhang, Hongbin, Ronaldo H. Szilard, Stephen Hess, and Rosemary Sugrue. A Strategic Approach to Employ Risk-Informed Methods to Enable Margin Recovery of Nuclear Power Plants Operating Margins. Office of Scientific and Technical Information (OSTI), September 2018. http://dx.doi.org/10.2172/1514992.

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Palmer, Guy, Varda Shkap, Wendy Brown, and Thea Molad. Control of bovine anaplasmosis: cytokine enhancement of vaccine efficacy. United States Department of Agriculture, March 2007. http://dx.doi.org/10.32747/2007.7695879.bard.

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Anaplasmosis an arthropod-born disease of cattle caused by the rickettsia Anaplasma marginale and is an impediment to efficient production of healthy livestock in both Israel and the United States. Currently the only effective vaccines are derived from the blood of infected cattle. The risk of widespread transmission of both known and newly emergent pathogens has prevented licensure of live blood-based vaccines in the U.S. and is a major concern for their continued use in Israel. Consequently development of a safe, effective vaccine is a high priority. In this collaborative project we focused on two approaches to vaccine development. The first focused o n improving antigen delivery to livestock and specifically examined how DNA vaccines could be improved to enhance priming and expansion of the immune response. This research resulted in development and testing of two novel vaccine delivery systems--one that targeted antigen spread among dendritic cells (the key cell in priming immune responses and a follow-on construct that also specifically targeted antigen to the endosomal-lysosomal compartment the processing organelle within the dendritic cell that directs vaccine antigen to the MHC class ll-CD4* T cell priming pathway). The optimized construct targeting vaccine antigen to the dendritic cell MHC class II pathway was tested for ability to prime A. marginale specific immune responses in outbred cattle. The results demonstrated both statistically significant effects of priming with a single immunization, continued expansion of the primary immune response including development of high affinity lgG antibodies and rapid recall of the memory response following antigen challenge. This portion of the study represented a significant advance in vaccine delivery for livestock. Importantly the impact of these studies is not limited to A. marginale a s the targeting motifs are optimized for cattle and can be adapted to other cattle vaccinations by inserting a relevant pathogen-specific antigen. The second approach (which represented an addition to the project for which approval was requested as part of the first annual report) was a comparative approach between A . marginale and the Israel A . centrale vaccines train. This addition was requested as studies on Major Surface Protein( MSP)- 2 have shown that this antigen is highly antigenically variable and presented solely as a "static vaccine" antigen does not give cross-strain immunity. In contrast A. . centrale is an effective vaccine which Kimron Veterinary institute has used in the field in Israel for over 50 years. Taking advantage of this expertise, a broad comparison of wild type A. marginale and vaccine strain was initiated. These studies revealed three primary findings: i) use of the vaccine is associated with superinfection, but absence of clinical disease upon superinfection with A. marginale; ii) the A. centrale vaccine strain is not only less virulent but transmission in competent in Dermacentor spp. ticks; and iii) some but not all MSPs are conserved in basic orthologous structure but there are significant polymorphisms among the strains. These studies clearly indicated that there are statistically significant differences in biology (virulence and transmission) and provide a clear path for mapping of biology with the genomes. Based on these findings, we initiated complete genome sequencing of the Israel vaccine strain (although not currently funded by BARD) and plant to proceed with a comparative genomics approach using already sequenced wild-type A. marginale. These findings and ongoing collaborative research tie together filed vaccine experience with new genomic data, providing a new approach to vaccine development against a complex pathogen.
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Newcomer, Justin, and Katherine Freeland. A margin based approach to determining sample sizes via tolerance bounds. Office of Scientific and Technical Information (OSTI), September 2013. http://dx.doi.org/10.2172/1096258.

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Smith, Curtis, and Diego Mandelli. Integrating Safety Assessment Methods using the Risk Informed Safety Margins Characterization (RISMC) Approach. Office of Scientific and Technical Information (OSTI), March 2013. http://dx.doi.org/10.2172/1097161.

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Newcomer, Justin T. A new approach to quantification of margins and uncertainties for physical simulation data. Office of Scientific and Technical Information (OSTI), September 2012. http://dx.doi.org/10.2172/1055920.

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Odette, G. R. An integrated approach to assessing the fracture safe margins of fusion reactor structures. Office of Scientific and Technical Information (OSTI), October 1996. http://dx.doi.org/10.2172/414889.

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Murray, Paul E., Ryan L. Marlow, and Joseph W. Nielsen. A Statistical Approach to Safety Margin Evaluation of Irradiation Experiments in the ATR. Office of Scientific and Technical Information (OSTI), December 2018. http://dx.doi.org/10.2172/1487271.

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