Готові списки джерел за темами / Lipid Vesicle

Добірка наукової літератури з теми "Lipid Vesicle"

Автор: Grafiati
Опубліковано: 7 вересня 2023

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Статті в журналах з теми "Lipid Vesicle"

1

McMaster, Christopher R. "Lipid metabolism and vesicle trafficking: More than just greasing the transport machinery." Biochemistry and Cell Biology 79, no. 6 (December 1, 2001): 681–92. http://dx.doi.org/10.1139/o01-139.

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The movement of lipids from their sites of synthesis to ultimate intracellular destinations must be coordinated with lipid metabolic pathways to ensure overall lipid homeostasis is maintained. Thus, lipids would be predicted to play regulatory roles in the movement of vesicles within cells. Recent work has highlighted how specific lipid metabolic events can affect distinct vesicle trafficking steps and has resulted in our first glimpses of how alterations in lipid metabolism participate in the regulation of intracellular vesicles. Specifically, (i) alterations in sphingolipid metabolism affect the ability of SNAREs to fuse membranes, (ii) sterols are required for efficient endocytosis, (iii) glycerophospholipids and phosphorylated phosphatidylinositols regulate Golgi-mediated vesicle transport, (iv) lipid acylation is required for efficient vesicle transport mediated membrane fission, and (v) the addition of glycosylphosphatidylinositol lipid anchors to proteins orders them into distinct domains that result in their preferential sorting from other vesicle destined protein components in the endoplasmic reticulum. This review describes the experimental evidence that demonstrates a role for lipid metabolism in the regulation of specific vesicle transport events.Key words: vesicle transport, trafficking, lipid, sterol, metabolism.
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2

Bar, Laure, George Cordoyiannis, Shova Neupane, Jonathan Goole, Patrick Grosfils, and Patricia Losada-Pérez. "Asymmetric Lipid Transfer between Zwitterionic Vesicles by Nanoviscosity Measurements." Nanomaterials 11, no. 5 (April 22, 2021): 1087. http://dx.doi.org/10.3390/nano11051087.

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The interest in nano-sized lipid vesicles in nano-biotechnology relies on their use as mimics for endosomes, exosomes, and nanocarriers for drug delivery. The interactions between nanoscale size lipid vesicles and cell membranes involve spontaneous interbilayer lipid transfer by several mechanisms, such as monomer transfer or hemifusion. Experimental approaches toward monitoring lipid transfer between nanoscale-sized vesicles typically consist of transfer assays by fluorescence microscopy requiring the use of labels or calorimetric measurements, which in turn require a large amount of sample. Here, the capability of a label-free surface-sensitive method, quartz crystal microbalance with dissipation monitoring (QCM-D), was used to monitor lipid transfer kinetics at minimal concentrations and to elucidate how lipid physicochemical properties influence the nature of the transfer mechanism and dictate its dynamics. By studying time-dependent phase transitions obtained from nanoviscosity measurements, the transfer rates (unidirectional or bidirectional) between two vesicle populations consisting of lipids with the same head group and differing alkyl chain length can be estimated. Lipid transfer is asymmetric and unidirectional from shorter-chain lipid donor vesicles to longer-chain lipid acceptor vesicles. The transfer is dramatically reduced when the vesicle populations are incubated at temperatures below the melting of one of the vesicle populations.
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3

Salac, David, and Michael J. Miksis. "Reynolds number effects on lipid vesicles." Journal of Fluid Mechanics 711 (August 31, 2012): 122–46. http://dx.doi.org/10.1017/jfm.2012.380.

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AbstractVesicles exposed to the human circulatory system experience a wide range of flows and Reynolds numbers. Previous investigations of vesicles in fluid flow have focused on the Stokes flow regime. In this work the influence of inertia on the dynamics of a vesicle in a shearing flow is investigated using a novel level-set computational method in two dimensions. A detailed analysis of the behaviour of a single vesicle at finite Reynolds number is presented. At low Reynolds numbers the results recover vesicle behaviour previously observed for Stokes flow. At moderate Reynolds numbers the classical tumbling behaviour of highly viscous vesicles is no longer observed. Instead, the vesicle is observed to tank-tread, with an equilibrium angle dependent on the Reynolds number and the reduced area of the vesicle. It is shown that a vesicle with an inner/outer fluid viscosity ratio as high as 200 will not tumble if the Reynolds number is as low as 10. A new damped tank-treading behaviour, where the vesicle will briefly oscillate about the equilibrium inclination angle, is also observed. This behaviour is explained by an investigation on the torque acting on a vesicle in shear flow. Scaling laws for vesicles in inertial flows have also been determined. It is observed that quantities such as vesicle tumbling period follow square-root scaling with respect to the Reynolds number. Finally, the maximum tension as a function of the Reynolds number is also determined. It is observed that, as the Reynolds number increases, the maximum tension on the vesicle membrane also increases. This could play a role in the creation of stable pores in vesicle membranes or for the premature destruction of vesicles exposed to the human circulatory system.
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4

Yu, Haijia, Yinghui Liu, Daniel R. Gulbranson, Alex Paine, Shailendra S. Rathore, and Jingshi Shen. "Extended synaptotagmins are Ca2+-dependent lipid transfer proteins at membrane contact sites." Proceedings of the National Academy of Sciences 113, no. 16 (April 4, 2016): 4362–67. http://dx.doi.org/10.1073/pnas.1517259113.

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Organelles are in constant communication with each other through exchange of proteins (mediated by trafficking vesicles) and lipids [mediated by both trafficking vesicles and lipid transfer proteins (LTPs)]. It has long been known that vesicle trafficking can be tightly regulated by the second messenger Ca2+, allowing membrane protein transport to be adjusted according to physiological demands. However, it remains unclear whether LTP-mediated lipid transport can also be regulated by Ca2+. In this work, we show that extended synaptotagmins (E-Syts), poorly understood membrane proteins at endoplasmic reticulum–plasma membrane contact sites, are Ca2+-dependent LTPs. Using both recombinant and endogenous mammalian proteins, we discovered that E-Syts transfer glycerophospholipids between membrane bilayers in the presence of Ca2+. E-Syts use their lipid-accommodating synaptotagmin-like mitochondrial lipid binding protein (SMP) domains to transfer lipids. However, the SMP domains themselves cannot transport lipids unless the two membranes are tightly tethered by Ca2+-bound C2 domains. Strikingly, the Ca2+-regulated lipid transfer activity of E-Syts was fully recapitulated when the SMP domain was fused to the cytosolic domain of synaptotagmin-1, the Ca2+ sensor in synaptic vesicle fusion, indicating that a common mechanism of membrane tethering governs the Ca2+ regulation of lipid transfer and vesicle fusion. Finally, we showed that microsomal vesicles isolated from mammalian cells contained robust Ca2+-dependent lipid transfer activities, which were mediated by E-Syts. These findings established E-Syts as a novel class of LTPs and showed that LTP-mediated lipid trafficking, like vesicular transport, can be subject to tight Ca2+ regulation.
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5

Kisak, E., M. Kennedy, and J. A. Zasadzinski. "Self-Limiting Aggregation By Controlled Ligand-Receptor Stoicfflometry and Its Use For a Novel Drug Delivery System." Microscopy and Microanalysis 5, S2 (August 1999): 1212–13. http://dx.doi.org/10.1017/s1431927600019383.

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Анотація:
Lipid vesicles are used as drug delivery vehicles for the slow sustained release of a drug compound to a specific site in the body. This translates to more efficient medication with limited side effects. Although unilamellar drug delivery vesicles have progressed greatly, they are still limited in there applications. Our group has designed a second generation drug release system, the “vesosome“ which incorporates an aggregate of lipid vesicles encapsulated in a second lipid membrane. The two separate membranes can be specialized to allow for increased drug encapsulation and better control over drug release rate, which leads to a more general drug delivery system.Lipid vesicle aggregates were formed by using a ligand-receptor system (biotinated lipids protruding from the vesicle surface crosslinked with streptavidin). The streptavidin/biotin system is one of the strongest in nature, providing specific binding.
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6

Willes, Keith L., Jasmyn R. Genchev, and Walter F. Paxton. "Hybrid Lipid-Polymer Bilayers: pH-Mediated Interactions between Hybrid Vesicles and Glass." Polymers 12, no. 4 (March 28, 2020): 745. http://dx.doi.org/10.3390/polym12040745.

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One practical approach towards robust and stable biomimetic platforms is to generate hybrid bilayers that incorporate both lipids and block co-polymer amphiphiles. The currently limited number of reports on the interaction of glass surfaces with hybrid lipid and polymer vesicles—DOPC mixed with amphiphilic poly(ethylene oxide-b-butadiene) (PEO-PBd)—describe substantially different conclusions under very similar conditions (i.e., same pH). In this study, we varied vesicle composition and solution pH in order to generate a broader picture of spontaneous hybrid lipid/polymer vesicle interactions with rigid supports. Using quartz crystal microbalance with dissipation (QCM-D), we followed the interaction of hybrid lipid-polymer vesicles with borosilicate glass as a function of pH. We found pH-dependent adsorption/fusion of hybrid vesicles that accounts for some of the contradictory results observed in previous studies. Our results show that the formation of hybrid lipid-polymer bilayers is highly pH dependent and indicate that the interaction between glass surfaces and hybrid DOPC/PEO-PBd can be tuned with pH.
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7

Cummings, Jason E., Donald P. Satchell, Yoshinori Shirafuji, Andre J. Ouellette та T. Kyle Vanderlick. "Electrostatically Controlled Interactions of Mouse Paneth Cell α-Defensins with Phospholipid Membranes". Australian Journal of Chemistry 56, № 10 (2003): 1031. http://dx.doi.org/10.1071/ch03110.

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Antimicrobial peptides of the innate immune systems of many organisms are known to interact with lipid membranes, with electrostatic interactions playing an important role. We have studied the interactions of the mouse α-defensin, cryptdin-4, and its precursor, procryptdin-4, with phospholipid model membranes in the form of vesicles. Both peptides induce ‘graded’ leakage of vesicle contents, however procryptdin-4 exhibits only minimal membrane disruptive activity. Vesicles containing a higher fraction of anionic lipid are more susceptible to peptide-induced leakage. Electrophoretic mobility measurements at several vesicle compositions reveal a correlation between the surface potential of vesicles and the peptide-induced vesicle leakage.
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8

Kamiya, Koki, Toshihisa Osaki, and Shoji Takeuchi. "Formation of vesicles-in-a-vesicle with asymmetric lipid components using a pulsed-jet flow method." RSC Advances 9, no. 52 (2019): 30071–75. http://dx.doi.org/10.1039/c9ra04622d.

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9

Miyamaru, Chiho, Mao Koide, Nana Kato, Shogo Matsubara, and Masahiro Higuchi. "Fabrication of CaCO3-Coated Vesicles by Biomineralization and Their Application as Carriers of Drug Delivery Systems." International Journal of Molecular Sciences 23, no. 2 (January 12, 2022): 789. http://dx.doi.org/10.3390/ijms23020789.

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Анотація:
We fabricated CaCO3-coated vesicles as drug carriers that release their cargo under a weakly acidic condition. We designed and synthesized a peptide lipid containing the Val-His-Val-Glu-Val-Ser sequence as the hydrophilic part, and with two palmitoyl groups at the N-terminal as the anchor groups of the lipid bilayer membrane. Vesicles embedded with the peptide lipids were prepared. The CaCO3 coating of the vesicle surface was performed by the mineralization induced by the embedded peptide lipid. The peptide lipid produced the mineral source, CO32−, for CaCO3 mineralization through the hydrolysis of urea. We investigated the structure of the obtained CaCO3-coated vesicles using transmission electron microscopy (TEM). The vesicles retained the spherical shapes, even in vacuo. Furthermore, the vesicles had inner spaces that acted as the drug cargo, as observed by the TEM tomographic analysis. The thickness of the CaCO3 shell was estimated as ca. 20 nm. CaCO3-coated vesicles containing hydrophobic or hydrophilic drugs were prepared, and the drug release properties were examined under various pH conditions. The mineralized CaCO3 shell of the vesicle surface was dissolved under a weakly acidic condition, pH 6.0, such as in the neighborhood of cancer tissues. The degradation of the CaCO3 shell induced an effective release of the drugs. Such behavior suggests potential of the CaCO3-coated vesicles as carriers for cancer therapies.
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10

Cohen, D. E., M. Angelico, and M. C. Carey. "Quasielastic light scattering evidence for vesicular secretion of biliary lipids." American Journal of Physiology-Gastrointestinal and Liver Physiology 257, no. 1 (July 1, 1989): G1—G8. http://dx.doi.org/10.1152/ajpgi.1989.257.1.g1.

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We employed quasielastic light scattering, negative-stain, and freeze-fracture electron microscopy to study the time-dependent physicochemical behavior of biliary lipids in fresh rat bile. Three to five minutes after bile collection, the earliest light scattering measurements and electron microscopy revealed unilamellar vesicles (mean hydrodynamic radius, Rh = 430-740 A) coexisting with mixed micelles (Rh = 20-120 A) in all biles. Both percent biliary vesicles (1 to greater than 70%) and micellar sizes varied inversely with bile salt concentration (range 1.6-72 mM) both during endogenous pool drainage and sodium taurocholate infusion. With bile salt concentrations in the vicinity of or below the estimated critical micellar concentration, biliary vesicle concentrations remained constant or increased slightly with passage of time. However, with micellar bile salt concentrations, complete conversion of vesicles to micelles occurred at rates that were directly proportional to bile salt concentration. Back-extrapolation of weighted Rh averages of micelles plus vesicles as functions of time gave sizes of approximately 470 A at 1 min, suggesting the predominance of homogeneously sized unilamellar vesicles at the earliest stages of bile formation. After micellization of lipids, mixed protein aggregates of vesicle size were demonstrated in all biles. These experiments elucidate the dynamic coexistence of lipid vesicles and mixed micelles in cholesterol unsaturated biles and demonstrate that vesicle-to-micelle interconversions of biliary lipid aggregates are normal physiological phenomena within the biliary tree.(ABSTRACT TRUNCATED AT 250 WORDS)
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Дисертації з теми "Lipid Vesicle"

1

Connell, E. J. "Protein-lipid interactions in synaptic vesicle exocytosis." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597894.

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The fusion of neurotransmitter-filled synaptic vesicles with the pre-synaptic membrane in response to calcium influx is exquisitely regulated. Synaptic vesicle exocytosis is energetically demanding and the neuronal SNARE proteins syntaxin, SNAP25 and synaptobrevin have come to prominence as the driving engines behind this process. Resident on both vesicular and pre-synaptic membranes they form a stable four-helical bundle, the assembly of which contributes to membrane fusion. However, SNAREs do not act in isolation during synaptic vesicle exocytosis but are instead regulated by a complex web of interactions with other proteins including synaptotagmin, a calcium-sensing component of the vesicle itself, and Munc18, a highly-conserved cytosolic protein. In addition, changes in the lipid environment surrounding the SNAREs play a critical role. In this thesis I report the results of two lines of investigation, into both synaptotagmin’s and Munc18’s action. Firstly, I consider the significance of the cytoplasmic double C2 domain structure of synaptotagmin. Using several strategies including a novel real-time absorbance assay, I show that these tandem C2 domains, but neither domain alone, rapidly cross-link lipid membranes in the presence of calcium. This property is conserved. Cross-linking ability can be masked in full-length synaptotagmin, via an electrostatic interaction with the membrane in which it is embedded. Finally, I address the mechanism of arachidonic acid action on syntaxin/Munc18, showing that this lipid activates Munc18-bound syntaxin and that a Munc18/syntaxin/SNAP25 assembly exists in brain. Arachidonic acid also activates free syntaxin, defining a molecular target for the reported role of this lipid in the promotion of vesicle fusion. My data are incorporated into a revised model of the protein-lipid interactions underlying synaptic vesicle exocytosis.
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2

Hamada, Tsutomu. "Morphological dynamics and biological functions in a cell-sized lipid vesicle." 京都大学 (Kyoto University), 2006. http://hdl.handle.net/2433/144128.

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Kyoto University (京都大学)
0048
新制・課程博士
博士(理学)
甲第12078号
理博第2972号
新制||理||1444(附属図書館)
23914
UT51-2006-J73
京都大学大学院理学研究科物理学・宇宙物理学専攻
(主査)教授 吉川 研一, 助教授 瀬戸 秀紀, 教授 小貫 明
学位規則第4条第1項該当
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3

Kausik, Ravinath, Brandon D. Armstrong, and Songi Han. "Study of local diffusion coefficients of the hydration layer of lipid vesicle bilayers." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-192351.

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Water molecules near the surface of vesicle bilayers exhibit slow dynamics with respect to that of pure bulk water as they belong to the hydration layer. We present a unique analysis tool for the selective detection of local water of the hydration layer on the surface of unilamellar vesicles and the determination of its diffusion coefficients. We utilized stable nitroxide radicals covalently attached to the hydrophilic head groups of DOPC lipid chains that incorporate along with other lipids into vesicles. Through the use of dynamic nuclear polarization (DNP) the 1H NMR signal of local water interacting with the radical is amplified, and we present here an analysis of the local diffusion coefficients of this hydration layer.
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4

Kausik, Ravinath, Brandon D. Armstrong, and Songi Han. "Study of local diffusion coefficients of the hydration layer of lipid vesicle bilayers." Diffusion fundamentals 10 (2009) 27, S. 1-4, 2009. https://ul.qucosa.de/id/qucosa%3A14118.

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Анотація:
Water molecules near the surface of vesicle bilayers exhibit slow dynamics with respect to that of pure bulk water as they belong to the hydration layer. We present a unique analysis tool for the selective detection of local water of the hydration layer on the surface of unilamellar vesicles and the determination of its diffusion coefficients. We utilized stable nitroxide radicals covalently attached to the hydrophilic head groups of DOPC lipid chains that incorporate along with other lipids into vesicles. Through the use of dynamic nuclear polarization (DNP) the 1H NMR signal of local water interacting with the radical is amplified, and we present here an analysis of the local diffusion coefficients of this hydration layer.
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5

Rouhvand, Bahar. "Vesicle-Protein Diffusion and Interaction Study Using Time Resolved Fluorescence Correlation Spectroscopy." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1503261462042903.

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6

Ashrafzadeh, Parham. "Exploring Cellular Dynamics : From Vesicle Tethering to Cell Migration." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306174.

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Анотація:
Cells in the body communicate with each other in order to cooperate efficiently. This communication is in part achieved by regulated secretion of signaling molecules, which when released from a cell may activate receptors present at the plasma membrane of an adjacent cell. Such signals affect both cell fate and behavior. Dysregulated signaling may lead to disease, including cancer. This thesis is focused on how exocytosis and subsequent activation and trafficking of receptors can be regulated, and what the consequences of this regulation may be for cell migration. Actin filaments are important transport structures for secretory vesicle trafficking. In Paper 1, actin polymerization was shown to induce formation of ordered lipid domains in the plasma membrane. Accordingly, actin filaments may thus create and stabilize specific membrane domains that enable docking of vesicles containing secretory cargo. The RhoGEF FGD5 regulates Cdc42 which can result in cytoskeletal rearrangements. In Paper II, FGD5 was shown to be selectively expressed in blood vessels and required for normal VEGFR2 signaling. FGD5 protected VEGFR2 from proteasome-mediated degradation and was essential for endothelial cells to efficiently respond to chemotactic gradients of VEGFA. The exocyst component EXOC7 is essential for tethering secretory vesicles to the plasma membrane prior to SNARE-mediated fusion. In Paper III, EXOC7 was required for trafficking of VEGFR2-containing vesicles to the inner plasma membrane and VEGFR2 presentation at the cell surface. The ability of tumor cells to escape the primary tumor and establish metastasis is in part dependent on their capacity to migrate. In Paper IV, a method based on time-lapse microscopy and fluorescent dyes was created to analyze single cancer cell migration in mixed cancer cell cultures, and in particular the influence of different types on neighboring cells was assessed. In conclusion, these studies have enhanced our understanding of the mechanisms behind cellular trafficking, and may be applied in the future to develop more specific therapeutics to treat cancer and other diseases associated with abnormal angiogenesis and cellular migration.
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7

Schwamborn, Miriam. "Establishment of a fluorescence assay for characterization of protein-mediated vesicle fusion and acidification." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2017. http://hdl.handle.net/11858/00-1735-0000-0023-3E83-7.

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8

Dun, Alison. "Spatial and temporal control of regulated exocytosis by protein and lipid interactions." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8087.

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Анотація:
Cellular communication requires the transport of chemical messengers between intracellular compartments and from cell to cell. The regulated exocytosis of a secretory vesicle at the plasma membrane involves the merger of two bilayers, with markedly different lipid composition, within a millisecond time scale. The spatial and temporal control of the protein and lipid complement at these fusion sites is essential. A highly conserved family of proteins are known to drive this fusion event; SNAP-25 and syntaxin-1 (t-SNAREs) associate at the plasma membrane in a 1:1 stoichiometry to provide a binding site for the vesicle-membrane protein synaptobrevin (v-SNARE). The formation of this complex and subsequent fusion requires accessory proteins for efficient calcium-triggered exocytosis; which of these proteins facilitate the initial attachment of vesicle to the plasma membrane prior to fusion is still under debate. Specific sites for vesicle fusion have been proposed and the organisation of lipids and proteins at these fusion sites has been extensively investigated with limited spatial and temporal resolution; however the presence of raft-forming lipids at these sites as well as the arrangement of SNARE proteins at the molecular level is still under contention. The data presented within this thesis aims to elucidate the protein and lipid environment at the fusion site using super-resolution microscopy and advanced vesicle tracking. Under diffraction-limited microscopy the t-SNAREs are visualised as 200 nm homogenous clusters; however I have used single molecule localisation microscopy to reveal a more complex heterogeneous molecular arrangement. Quantification of lipid order exclusively at the plasma membrane provided insight into the influence of cholesterol-induced lipid arrangement on SNAP-25 localisation. In addition the t-SNARE interaction was investigated using TCSPC-FLIM identifying two lipid-order-dependent conformations in distinct clusters at the plasma membrane. Extensive vesicle tracking at optimum sampling rates demonstrated the ‘sampling’ behaviour of LDCVs and allowed characterisation of vesicle fusion sites. In summary I find that vesicles exhibit preference for residence and probably fusion at regions of plasma membrane with a low t-SNARE density; these proteins appear to exert control over exocytosis by adopting alternative conformations that are under cholesterol-induced regulation.
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9

Harman, Alison. "A Molecular Dynamics Simulation of Vesicle Deformation and Rupture in Confined Poiseuille Flow." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/26127.

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Vesicles are simple structures, but display complex, non-linear dynamics in fluid flow. I investigate the deformation of nanometer-sized vesicles, both fully-inflated and those with excess area, as they travel in tightly confined capillaries. By varying both channel size and flow strength, I simulate vesicles as they transition from steady-state to unstable shapes, and then rupture in strong flow fields. By employing a molecular dynamics model of the vesicle, fluid, and capillary system one is able to rupture the lipid bilayer of these vesicles. This is unique in that most other numerical methods for modelling vesicles are unable to show rupture. The rupture of fully-inflated vesicles is applicable to drug delivery in which the release of the encapsulated medicine needs to be controlled. The deformation and rupture of vesicles with excess area could be applicable to red blood cells which have similar rheological properties.
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10

Kuhlmann, Jan Wilhelm. "Modulation of lateral membrane tension and SNARE-mediated single vesicle fusion on pore spanning membranes." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2017. http://hdl.handle.net/11858/00-1735-0000-0023-3F13-E.

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Книги з теми "Lipid Vesicle"

1

Royal Society of Chemistry. Faraday Division., ed. Lipid vesicles and membranes. London: The Faraday Divison, The Royal Society of Chemistry, 1987.

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2

Royal Society of Chemistry (Great Britain). Faraday Division, ed. Lipid vesicles and membranes. London: Faraday Division, Royal Society of Chemistry, 1986.

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3

Ravoo, Bart Jan. Membrane fusion of vesicles of oligomerisable lipids. [S.l: s.n.], 1998.

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4

Power, Carl A. Uptake and tissue distribution of lipid vesicles (liposomes) after intraperitoneal injection into rainbow trout (Oncorhynchus mykiss). Charlottetown: University of Prince Edward Island, 1990.

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5

Power, Carl A. Uptake and tissue distribution of lipid vesicles (liposomes) after intraperitoneal injection into rainbow trout (Oncorhynchus mykiss). Ottawa: National Library of Canada, 1990.

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6

Crowell, Kevin James. Solid state deuterium nuclear magnetic resonance investigation of the interaction of positively-charged polyelectrolytes with negatively-charged lipid bilayer membrane vesicles. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1999.

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7

J, McIlhinney R. A., and Hooper N. M, eds. Lipids, rafts and traffic: Biochemical Society symposium no. 72, held at BioScience2004, Glasgow, July 2004. London: Portland Press, 2005.

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8

Giant Vesicle Book. Taylor & Francis Group, 2019.

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9

Marques, Carlos, and Rumiana Dimova. Giant Vesicle Book. Taylor & Francis Group, 2019.

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10

Marques, Carlos, and Rumiana Dimova. Giant Vesicle Book. Taylor & Francis Group, 2022.

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Частини книг з теми "Lipid Vesicle"

1

Dao, Thi Phuong Tuyen, Khalid Ferji, Fabio Fernandes, Manuel Prieto, Sébastien Lecommandoux, Emmanuel Ibarboure, Olivier Sandre, and Jean-François Le Meins. "Giant hybrid polymer/lipid vesicles." In The Giant Vesicle Book, 551–68. Boca Raton, FL : CRC Press, Taylor & Francis Group, [2020]: CRC Press, 2019. http://dx.doi.org/10.1201/9781315152516-27.

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2

Hu, Peichi C., and Noah Malmstadt. "Asymmetric Giant Lipid Vesicle Fabrication." In Methods in Molecular Biology, 79–90. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1752-5_7.

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Ugarte-Uribe, Begoña, Kushal Kumar Das, and Ana J. García-Sáez. "Lipid and protein mobility in giant unilamellar vesicles." In The Giant Vesicle Book, 455–71. Boca Raton, FL : CRC Press, Taylor & Francis Group, [2020]: CRC Press, 2019. http://dx.doi.org/10.1201/9781315152516-21.

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Parra-Ortiz, Elisa, and David Needham. "Mechanic assays of synthetic lipid membranes based on micropipette aspiration." In The Giant Vesicle Book, 283–304. Boca Raton, FL : CRC Press, Taylor & Francis Group, [2020]: CRC Press, 2019. http://dx.doi.org/10.1201/9781315152516-11.

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Frohnmayer, Johannes P., Marian Weiss, Lucia T. Benk, Jan-Willi Janiesch, Barbara Haller, Rafael B. Lira, Rumiana Dimova, Ilia Platzman, and Joachim P. Spatz. "Droplet-stabilized giant lipid vesicles as compartments for synthetic biology." In The Giant Vesicle Book, 601–17. Boca Raton, FL : CRC Press, Taylor & Francis Group, [2020]: CRC Press, 2019. http://dx.doi.org/10.1201/9781315152516-30.

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Pépin-Donat, Brigitte, François Quemeneur, and Clément Campillo. "Lipid-polymer interactions: Effect on giant unilamellar vesicle shape and behavior." In The Giant Vesicle Book, 519–33. Boca Raton, FL : CRC Press, Taylor & Francis Group, [2020]: CRC Press, 2019. http://dx.doi.org/10.1201/9781315152516-25.

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7

Montecucco, Cesare. "Cell Vesicle Trafficking and Bacterial Protein Toxins." In Lipid and Protein Traffic, 255–65. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-51463-0_23.

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Marianelli, Allyson M., and Christine D. Keating. "Encapsulation of aqueous two-phase systems and gels within giant lipid vesicles." In The Giant Vesicle Book, 585–99. Boca Raton, FL : CRC Press, Taylor & Francis Group, [2020]: CRC Press, 2019. http://dx.doi.org/10.1201/9781315152516-29.

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Wirtz, Karel W. A., and Gerry T. Snoek. "Phosphatidylinositol Transfer Protein and Membrane Vesicle Flow." In New Developments in Lipid—Protein Interactions and Receptor Function, 227–34. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2860-9_21.

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Choi, Hyewon, Kunyou Park, Victor W. Hsu, and Seung-Yeol Park. "Studying the Role of Lipid Geometry in COPI Vesicle Formation." In Methods in Molecular Biology, 519–28. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2639-9_30.

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Тези доповідей конференцій з теми "Lipid Vesicle"

1

Sadik, Mohamed M., David I. Shreiber, Jerry W. Shan, and Hao Lin. "Extreme Elongation of Vesicles Under DC Electric Fields." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-68102.

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Анотація:
Electrodeformation refers to the deformation of cell or vesicle lipid membranes under the application of an electric field. Such a phenomenon often accompanies electroporation processes, and also can be leveraged to detect pathological changes in cells. Recent studies have suggested that the electrical conductivity difference across the lipid membrane is a dominant factor in determining the characteristics of deformation, and various regimes of deformation were observed. Using a vesicle model system, the current work is the first report of extreme elongation of vesicles of high conductivity ratio under DC electric fields. The results suggest that the osmolarity difference between the encapsulated and bathing solutions may contribute to such abnormal deformation behavior.
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Kim, A. Ra, James J. Moon, Darrell J. Irvine, Sunghwan Jung, and Soong Ho Um. "DNA nanogel encapsulated by a lipid vesicle." In 2010 IEEE 10th Conference on Nanotechnology (IEEE-NANO). IEEE, 2010. http://dx.doi.org/10.1109/nano.2010.5697779.

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Webley, Ann-Dorie, Stephanie Dungan, and Susan Ebeler. "Local distribution of limonene in phospholipid vesicles." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/qxcj6124.

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The efficacy and quality of food products is affected by the distribution of hydrophobic solutes such as flavours and bioactive compounds. In order to improve food design, it is important to determine the local distribution of these solutes and the factors that affect their stability, incorporation and release. Colloidal assemblies of phospholipids are of particular interest, as they comprise safe, widespread natural amphiphiles that can solubilize hydrophobic compounds. However, there is a lack of accurate and non-destructive methods to study the local distribution of solutes between the sample matrix elements, the aqueous phase, and the vapor phase, making it difficult to assess the effect of structure on stability and release. Short time headspace microextraction allows us to determine the local distribution of hydrophobic solutes and the effect of colloidal structure while keeping the system intact. Using thermodynamic relationships, the detected concentrations of compounds in the vapour phase are used to determine local properties within the sample matrix. The colloids of focus in this study were phosphatidylcholine vesicles which were used to extend our previous work on micellar solutions by developing a quantification method for the solubilization and retention of volatile nonpolar compounds in vesicles. The local partitioning of the aroma molecule, limonene, was investigated in vesicles of various structures, lipid compositions, and at different temperatures. Vesicles were found to be much more effective at solubilizing limonene than short-chain phosphatidylcholine micelles. They yielded vesicle-water partition coefficients of ~104M–1 while the micelles had micelle-water partition coefficients of ~103M-1. Lipid composition and vesicle size did not have a significant effect on the partitioning properties, however, reducing the limonene concentration in the vesicles lowered the partition coefficient, suggesting some interaction effect at higher limonene concentrations. In addition, with saturated lipids, limonene fluidizes the gel membrane and lowers the phase transition temperature.
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Lu, Li, Jeffrey W. Schertzer, and Paul R. Chiarot. "Synthetic Asymmetric Vesicles Built Using Microfluidic Technology at High-Throughput." In ASME 2015 13th International Conference on Nanochannels, Microchannels, and Minichannels collocated with the ASME 2015 International Technical Conference and Exhibition on Packaging and Integration of Electronic and Photonic Microsystems. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/icnmm2015-48556.

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We report on a novel microfluidic strategy for building monodisperse asymmetric vesicles with customized composition, size, and interfacial properties at high-throughput. The microfluidic device encompasses a triangular post region and two flow-focusing regions. The major steps involved in the vesicle building process include: (1) forming highly uniform water emulsion templates in the inner-leaflet lipid solution, (2) replacing the inner-leaflet lipid solution with the outer-leaflet lipid solution, (3) creating water-in-oil-in-water double emulsions, and (4) extracting the excess outer-leaflet lipid solution from the double emulsions. Bilayer membrane asymmetry and unilamellarity are confirmed using a fluorescence quenching assay and quantitative measurements of fluorescent intensities. This method addresses many of the deficiencies found in existing technologies, and yields asymmetries as high as 95%. The asymmetric vesicles built using this strategy hold the potential to serve as model systems to investigate fundamental problems in membrane biology.
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Kamiya, Koki, Ryuji Kawano, Toshihisa Osaki, and Shoji Takeuchi. "Vesicles in a vesicle: Formation of a cell-sized vesicle containing small vesicles from two planar lipid bilayers using pulsed jet flow." In 2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2013. http://dx.doi.org/10.1109/memsys.2013.6474398.

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Zupanc, Jernej, Erhan Bas, and Deniz Erdogmus. "Analysis of lipid vesicle populations from microscopy video sequences." In 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2010). IEEE, 2010. http://dx.doi.org/10.1109/iembs.2010.5626223.

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EzzEldin, Hussein M., and Santiago D. Solares. "Calculation of Isothermal Intrinsic Compressibility and Compression of GvpA Protein in Halobacterium sp. NRC-1 Using Molecular Modeling and Dynamics." In ASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2009. http://dx.doi.org/10.1115/detc2009-86265.

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Gas vesicles are low-density, gas-filled protein organelles found inside various microorganisms. They have a lipid-free membrane with an average thickness of 2 nm and provide their hosts with buoyancy. In this study we characterized gas vesicle proteins synthesized by the Halobacterium sp. NRC-1 strain making use of molecular modeling methods and molecular dynamics (MD) simulations. The tertiary structure of GvpA protein, the major constituent of the gas vesicle membrane, was predicted using the De Novo computational design method available in the Rosetta Suite 2.3.1 software and was found to be in agreement with experimental data available from previous studies conducted by others and the consensus of different secondary structure prediction web servers. Optimization of the predicted structure was first carried out by energy minimization and simulated annealing. Subsequently, the mechanical properties of GvpA were investigated via constant pressure and temperature (NPT) aqueous MD simulations, in which two approaches were used to study the isothermal compressibility: quantification of the fluctuations in protein volume at constant pressure and temperature, and quantification of the volume changes induced through changes in the simulation pressure. Long term we plan to incorporate this information into multi-scale models of whole gas vesicles.
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Zheng, Siyang, Hongzhang He, Faming Wang, and Yuan Wan. "Abstract B53: Extracellular vesicle-based liquid biopsy via lipid-based nanoprobes." In Abstracts: AACR Special Conference on Advances in Liquid Biopsies; January 13-16, 2020; Miami, FL. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1557-3265.liqbiop20-b53.

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9

Piñón, Tessa M., Linda S. Hirst, and Jay E. Sharping. "Fiber-Based Dual-Beam Optical Trapping System for Studying Lipid Vesicle Mechanics." In Optical Trapping Applications. Washington, D.C.: OSA, 2011. http://dx.doi.org/10.1364/ota.2011.ottub2.

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10

Noguchi, Hiroshi. "Structure formation of lipid membranes: Membrane self-assembly and vesicle opening-up to octopus-like micelles." In 4TH INTERNATIONAL SYMPOSIUM ON SLOW DYNAMICS IN COMPLEX SYSTEMS: Keep Going Tohoku. American Institute of Physics, 2013. http://dx.doi.org/10.1063/1.4794634.

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