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Статті в журналах з теми "Lineage decision"
Karasek, Challis, Mohamed Ashry, Chad S. Driscoll, and Jason G. Knott. "A tale of two cell-fates: role of the Hippo signaling pathway and transcription factors in early lineage formation in mouse preimplantation embryos." Molecular Human Reproduction 26, no. 9 (July 9, 2020): 653–64. http://dx.doi.org/10.1093/molehr/gaaa052.
Повний текст джерелаCornejo, Melanie G., Vinciane Mabialah, Stephen M. Sykes, Tulasi Khandan, Cristina Lo Celso, Cécile K. Lopez, Paola Rivera-Muñoz, et al. "Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification." Blood 118, no. 5 (August 4, 2011): 1264–73. http://dx.doi.org/10.1182/blood-2011-01-328567.
Повний текст джерелаZeddies, Sabrina, Sjoert Jansen, Franca di Summa, Sofieke Klamer, Marion Kleier, Jaap Jan Zwaginga, Marieke von Lindern, C. Ellen Van der Schoot, and Daphne C. Thijssen-Timmer. "MEIS1 Regulates Early Erythroid and Megakaryocytic Lineage Decision." Blood 118, no. 21 (November 18, 2011): 2365. http://dx.doi.org/10.1182/blood.v118.21.2365.2365.
Повний текст джерелаVALDEZ, P., and E. ROBEY. "Notch and the CD4 Versus CD8 Lineage Decision." Cold Spring Harbor Symposia on Quantitative Biology 64 (January 1, 1999): 27–32. http://dx.doi.org/10.1101/sqb.1999.64.27.
Повний текст джерелаTaniuchi, Ichiro. "Transcriptional regulation in helper versus cytotoxic-lineage decision." Current Opinion in Immunology 21, no. 2 (April 2009): 127–32. http://dx.doi.org/10.1016/j.coi.2009.03.012.
Повний текст джерелаAkashi, Koichi. "Lymphoid Lineage Fate Decision of Hematopoietic Stem Cells." Annals of the New York Academy of Sciences 1176, no. 1 (September 2009): 18–25. http://dx.doi.org/10.1111/j.1749-6632.2009.04570.x.
Повний текст джерелаEnver, Tariq, and Sui Huang. "Mathematical Modeling of Transcriptional Regulatory Circuits Defines Cell Fate Attractors and Predicts the Genome-Scale Behaviour of Haemopoietic Progenitor Cells Undergoing a Binary Cell Fate Decision." Blood 106, no. 11 (November 16, 2005): 4219. http://dx.doi.org/10.1182/blood.v106.11.4219.4219.
Повний текст джерелаde Leeuw, David C., Willemijn de van den Ancker, Fedor Denkers, Renee X. de Menezes, Theresia M. Westers, Gert J. Ossenkoppele, Arjan A. Van de Loosdrecht, and Linda Smit. "Microrna Profiling Classifies Acute Leukemias of Ambiguous Lineage As Either Acute Myeloid Leukemia or Acute Lymphoid Leukemia." Blood 120, no. 21 (November 16, 2012): 1443. http://dx.doi.org/10.1182/blood.v120.21.1443.1443.
Повний текст джерелаOrgogozo, Virginie, François Schweisguth, and Yohanns Bellaïche. "Binary cell death decision regulated by unequal partitioning of Numb at mitosis." Development 129, no. 20 (October 15, 2002): 4677–84. http://dx.doi.org/10.1242/dev.129.20.4677.
Повний текст джерелаBrown, Geoffrey. "Towards a New Understanding of Decision-Making by Hematopoietic Stem Cells." International Journal of Molecular Sciences 21, no. 7 (March 29, 2020): 2362. http://dx.doi.org/10.3390/ijms21072362.
Повний текст джерелаДисертації з теми "Lineage decision"
Meng, Lingzhang [Verfasser]. "The impact of B-lineage derived IL-10 on fate decision of monocyte differentiation / Lingzhang Meng." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2016. http://d-nb.info/1096832577/34.
Повний текст джерелаChain, Jennifer Lee. "Elucidating the mechanisms of the human [alphabeta] vs. [gammadelta] lineage decision and the details of [gammadelta] thymocyte development." Oklahoma City : [s.n.], 2005.
Знайти повний текст джерелаBröske, Ann-Marie Elisabeth. "The level of DNA methylation impacts self-renewal capacity and lineage choices of hematopoietic stem cells." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16099.
Повний текст джерелаDNA methylation is one of the major epigenetic mechanisms which is known to play a role in embryonic stem cell fate, but its function in somatic stem cells is not well understood. In this thesis two different genetic mouse models were chosen to address the role of DNA methyltransferase 1 (DNMT1) controlled DNA methylation in adult hematopoiesis. First, a conditional knockout approach was used to delete DNMT1 in the adult hematopoietic system. Second, DNMT1 hypomorphic mice with reduced DNMT1 expression were analyzed. Complete DNMT1 deletion in hematopoietic cells led to severe cytopenia and anemia causing rapid lethality of all animals. Bone marrow analysis revealed an almost complete absence of hematopoietic stem and progenitor cells in DNMT1 ablated primary mice as well as in secondary chimeric mice. These results indicated that DNMT1 controlled maintenance of DNA methylation is indispensable for HSCs preservation and differentiation. In contrast to complete DNMT1 deletion, mice with hypomorphic DNMT1 expression were viable, but showed low methylation levels in multiple tissues including the hematopoietic system. Detailed phenotypical and functional analysis of the hypomethylated hematopoietic stem cell (HSCs) compartment revealed an impaired homeostasis and self-renewal capacity. Intriguingly, mutant animals had profoundly reduced lymphoid cell compartments, whereas myeloid and erythroid compartments were unchanged. Expression profiling of stem and myeloid progenitor cells unexpectedly demonstrated that reduced DNA methylation forces the HSC to adopt a myeloid lineage identity. These results, showing the inability of hypomethylated HSCs to maintain an undifferentiated state, provided an explanation for their disturbed capability to self-renew and produce lymphocytes. Taken together, these findings suggest that distinct levels of DNA methylation are required to control different functional programs such as self-renewal and alternative lineage choices in HSCs, thus uncovering a previously unrecognized function for DNMT1 activity.
Di, Tullio Alessandro 1982. "Reprogramming of B cells into macrophages: mechanistic insights." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/85722.
Повний текст джерелаRecientemente, nuestro grupo ha demostrado que las células pre-B se pueden reprogramar a macrófagos mediante la sobreexpresión del factor de transcripción C/EBP, con una eficiencia elevada. Así mismo, mediante la expresión de la forma inducible de C/EBP en una línea de células pre-B (C11), éstas también se puede convertir en células similares a macrófagos. Usando este sistema hemos estudiado si durante el proceso de trans-diferenciacion las células requieren volver a un estadio de célula precursora, y si el ciclo celular es necesario para este proceso. En cuanto a la primera cuestión, el análisis del transcriptoma de células trans-diferenciadas mostró que la expresión de la mayoría de los genes están regulados durante todo el proceso bien aumentando o disminuyendo, y que adquieren el fenotipo de macrófago a los 5 días después de iniciar el proceso. Así mismo, se observó la reactivación transitoria de un grupo de genes que codifican para marcadores de células mieloides inmaduras; también cabe destacar que observamos una disminución en la expresión de los genes expresados en células progenitoras Kit y Flt3, así como de genes de linajes impropios. Es importante destacar que nunca hemos llegado a observar la expresión de combinaciones de marcadores de superficie característicos de las células madre hematopoyéticas y las células progenitoras (HSPCs), incluyendo c-Kit y Flt3, mediante el análisis por citometría de flujo. Estos resultados se reprodujeron incluso cuando C/EBP se sobreexpresó en células pre-B que fueron cultivadas en condiciones que favorecen el crecimiento de las HSPC o cuando el factor de transcripción se activó de forma limitada en el tiempo. En cuanto a la segunda pregunta, usando la línea de células inducibles pre-B C11, el análisis mediante microscopia a diferentes tiempos después de la inducción de la reprogramación mostraron que una subpoblación de aproximadamente el 8% de las células pre-B no se dividen antes de adquirir las propiedades de macrófago, mientras que la mayoría de las células se dividen sólo una vez y un pequeño porcentaje dos veces antes de que se reprogramen totalmente a macrófagos. De acuerdo con estos resultados se encontró que un 8% de las células inducidas no incorporan BrdU durante la reprogramación. Es importante destacar que el subconjunto de células que no se dividen expresan los niveles más altos de C/EBP, con lo que cabe pensar que la adquisición del fenotipo de macrófago es más rápida en estas células. La inhibición de la síntesis de ADN por afidicolina bloqueó la transdiferenciación en mas de un 70% de las células, lo que sugiere que la correcta progresión del ciclo celular es un requisito para la transdiferenciación. Sin embargo, al separar la linea de células pre-B C11 en fracciones G0/G1 y G2/M seguido de la inducción, la cinética de la reprogramación no mostró diferencias significativas. Por último, también demostramos que la reducción en la expresión de p53 en las células pre-B inducibles no altera el proceso de conversión a macrófago, lo que sugiere que la aceleración del ciclo celular no tiene ningún efecto. En conjunto, nuestros resultados muestran que la conversión de células pre-B a macrófagos no requiere retro-diferenciación y que las células con una expresión mayor de C/EBP pueden llegar a prescindir de la dependencia del ciclo celular para la trans-diferenciación de las células inmunitarias.
Morgani, Sophie Maria. "Signalling and transcriptional regulation of early developmental lineage decisions." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9660.
Повний текст джерелаKoutsoukis, Nikitas-Spiros. "Decision modelling and information systems : the interaction of information and decision technologies." Thesis, Brunel University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263519.
Повний текст джерелаBraathen, Jørgen, and Anders Lund Eriksrud. "Hydropower Bidding Using Linear Decision Rules." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for industriell økonomi og teknologiledelse, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-24844.
Повний текст джерелаMendes, Mirian Patricia Sanches. "Aplicação da programação linear na decisão económica de investimento." Master's thesis, Instituto Politécnico de Setúbal. Escola Superior de Ciências Empresariais, 2014. http://hdl.handle.net/10400.26/7883.
Повний текст джерелаConsiderando o atual contexto empresarial, que se caracteriza por uma elevada competitividade a nível global, é essencial que os gestores tomem decisões que contribuam para criação de valor e para a sustentabilidade competitiva das empresas. Assim, o objetivo desta dissertação de mestrado é evidenciar que a programação linear pode contribuir para a maximização da criação de valor, através da sua utilização no estudo das decisões económicas de investimento das empresas. Tais decisões acarretam riscos elevados porque condicionam a capacidade de produção e o tipo de vantagens competitivas a criar e, por isso, devem ser capazes de responder ao nível de crescimento esperado do mercado e aos fatores críticos de sucesso dos negócios. Para além disso, são decisões que envolvem normalmente montantes avultados de capitais e que exigem a entrada de dinheiro por parte dos proprietários e a negociação de fontes de financiamento de médio e longo prazo que irão condicionar durante muito tempo a tesouraria da empresa. Como tal, este trabalho de investigação pretende, através da realização de um estudo de caso sobre uma empresa de serviços, evidenciar que a programação linear poderá dar um forte contributo sobre a otimização deste tipo de decisões. O trabalho é constituído por duas partes principais. A primeira contém uma revisão bibliográfica dos principais assuntos abordados, tanto ao nível dos conceitos financeiros como da programação linear. A segunda parte, relativa ao estudo empírico, é constituída pelo capítulo 3, onde são descritos mais em pormenor os objetivos e a metodologia de investigação utilizada e pelo capítulo 4 onde é desenvolvido o estudo de caso. Por fim, ainda são apresentadas as principais conclusões sobre o trabalho desenvolvido. Ao nível dos resultados de investigação obtidos, demonstra-se que através da aplicação da programação linear é possível maximizar os cash-flows anuais, através da determinação do mix de serviços que a empresa deve oferecer, considerando os preços de venda, a estrutura de custos e de ativos, bem como a capacidade dos recursos existentes (Horas/Homem de cada tipo de serviço a realizar).
Considering the current business environment that is characterized by high global competitiveness, it is essential that managers make decisions that contribute to value creation and competitive sustainability of companies. Thus, the objective of this thesis is to show that linear programming can contribute to the maximization of value creation through their use in the study of economic investment decisions of companies. Such decisions entail high risks, because they limited the capacity and the type of competitive advantages to create, and therefore must be able to respond to the expected level of market growth and to the critical factors of business success. Furthermore those decisions usually involve large amounts of capital and require entry of money by owners and the negotiation of medium and long term funding sources that will limit for a long time the treasure of the company. As such, this research work intends to show, by conducting a case study on a service company, that linear programming can make a strong contribution on the optimization of these kinds of decisions. The thesis consists of two mains parts. The first part contains a literature review of the main issues discussed both to the concept of financial and linear programming. The second part on the empirical study is composed by chapter 3 where described in more detail the objectives and the methodology used, and chapter 4 where the case study is developed. In relation to the results of the investigation, it is demonstrated that by applying linear programming it is possible to maximize the annual cash flows, by determining the mix of services that the company should offer, considering the sales prices, the structure of costs and assets, as well as the capacity of existing resources (hours/man of each type of service to be attain).
Patrascu, Relu-Eugen. "Linear Approximations For Factored Markov Decision Processes." Thesis, University of Waterloo, 2004. http://hdl.handle.net/10012/1171.
Повний текст джерелаSpiropoulos, Takis. "Decision support for management using Bayes linear influence diagrams." Thesis, University of Sunderland, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259788.
Повний текст джерелаКниги з теми "Lineage decision"
Faulkner, Laurie. Linear programming for management decision making. Leicester: Leicester Business School, De Montfort University, 1992.
Знайти повний текст джерелаBartels, Sibylle. Entwicklung und Beurteilung von Aggregationsstrategien für lineare Entscheidungsmodelle. Frankfurt am Main: P. Lang, 1986.
Знайти повний текст джерелаEiguren, Jakoba. Soft-decision decoding algorithms for linear block codes. Manchester: University of Manchester, 1994.
Знайти повний текст джерелаPham, Khanh D. Linear-Quadratic Controls in Risk-Averse Decision Making. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-5079-5.
Повний текст джерелаAnderson, David Ray. An introduction to management science: Quantitative approaches to decision making. 7th ed. Minneapolis/St. Paul: West Pub. Co., 1994.
Знайти повний текст джерелаAnderson, David Ray. An introduction to management science: Quantitative approaches to decision making. 8th ed. Minneapolis/St. Paul: West Pub. Co., 1997.
Знайти повний текст джерелаAnderson, David Ray. An introduction to management science: Quantitative approaches to decision making. 5th ed. St. Paul: West Pub. Co., 1988.
Знайти повний текст джерелаJ, Sweeney Dennis, and Williams Thomas Arthur 1944-, eds. An introduction to management science: Quantitative approaches to decision making. 4th ed. St. Paul: West Pub. Co., 1985.
Знайти повний текст джерелаAnderson, David Ray. An introduction to management science: Quantitative approaches to decision making. 6th ed. St. Paul, Minn: West Pub. Co., 1991.
Знайти повний текст джерелаJ, Sweeney Dennis, and Williams Thomas Arthur 1944-, eds. An introduction to management science: Quantitative approaches to decision making. 9th ed. Cincinnati: South-Western College Publishing, 2000.
Знайти повний текст джерелаЧастини книг з теми "Lineage decision"
Hoffman, Eric S., Lorena Passoni, Erastus C. Dudley, Michael Girardi, and Adrian Hayday. "The αβ/γδ Lineage Decision." In Molecular Biology of B-Cell and T-Cell Development, 367–96. Totowa, NJ: Humana Press, 1998. http://dx.doi.org/10.1007/978-1-4757-2778-4_19.
Повний текст джерелаKroening, Daniel, and Ofer Strichman. "Linear Arithmetic." In Decision Procedures, 97–133. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-50497-0_5.
Повний текст джерелаOwen, Guillermo. "Linear Programming." In Theory and Decision Library, 27–112. Boston, MA: Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4991-8_2.
Повний текст джерелаRommelfanger, Heinrich. "Lineare Optimierungsmodelle mit Flexiblen Restriktions-Grenzen." In Fuzzy Decision Support-Systeme, 170–217. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-57929-5_9.
Повний текст джерелаKimbrough, Steven Orla, and Hoong Chuin Lau. "Linear Programming." In Business Analytics for Decision Making, 43–58. Boca Raton: CRC Press, [2016]: Chapman and Hall/CRC, 2018. http://dx.doi.org/10.1201/9781315372426-3.
Повний текст джерелаde Miranda, João Luís. "Linear Algebra." In Introduction to Optimization-Based Decision-Making, 17–34. Boca Raton: Chapman and Hall/CRC, 2021. http://dx.doi.org/10.1201/9781315200323-2.
Повний текст джерелаLotov, Alexander V., Vladimir A. Bushenkov, and Georgy K. Kamenev. "Non-Linear Systems and Other New Developments." In Interactive Decision Maps, 129–62. Boston, MA: Springer US, 2004. http://dx.doi.org/10.1007/978-1-4419-8851-5_5.
Повний текст джерелаLotov, Alexander V., Vladimir A. Bushenkov, and Georgy K. Kamenev. "Perturbations of Solution Sets of Linear Systems." In Interactive Decision Maps, 263–78. Boston, MA: Springer US, 2004. http://dx.doi.org/10.1007/978-1-4419-8851-5_9.
Повний текст джерелаSrinivasan, R. "Introduction to Linear Programming." In Strategic Business Decisions, 9–21. New Delhi: Springer India, 2014. http://dx.doi.org/10.1007/978-81-322-1901-9_2.
Повний текст джерелаRommelfanger, Heinrich. "Lineare Optimierungsmodelle mit Fuzzy-Restriktionen und/oder Fuzzy-Zielen." In Fuzzy Decision Support-Systeme, 218–81. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-57929-5_10.
Повний текст джерелаТези доповідей конференцій з теми "Lineage decision"
Azevedo, Leonardo Guerreiro, Renan Souza, Raphael Melo Thiago, Elton Soares, and Marcio Moreno. "Experiencing ProvLake to Manage the Data Lineage of AI Workflows." In Simpósio Brasileiro de Sistemas de Informação. Sociedade Brasileira de Computação (SBC), 2020. http://dx.doi.org/10.5753/sbsi.2020.13144.
Повний текст джерелаMa, Jing, Guijian Yu, Chengcheng Wang, Xiaowei Jin, Chuanzhen Zang, Qing Li, Hongtao Wang, et al. "Best Practice of Bit Optimization in a Strong Heterogeneity Conglomeratic Sandstone Reservoir: 8 Years Case History from Juggar Basin, West China." In IADC/SPE Asia Pacific Drilling Technology Conference. SPE, 2021. http://dx.doi.org/10.2118/201086-ms.
Повний текст джерелаBadarinath, Rakshith, Kai-Wen Tien, and Vittaldas Prabhu. "Unified Control of Production, Capacity, and Pre-Emptive Maintenance of Fused Filament Fabrication Process." In ASME 2018 13th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/msec2018-6641.
Повний текст джерелаBjörner, Anders, László Lovász, and Andrew C. C. Yao. "Linear decision trees." In the twenty-fourth annual ACM symposium. New York, New York, USA: ACM Press, 1992. http://dx.doi.org/10.1145/129712.129730.
Повний текст джерелаKrishnamachari, Ramprasad, Srinivas Vadde, Janet K. Allen, and Farrokh Mistree. "Simultaneous Kinematic and Dynamic Synthesis in the Preliminary Design of a Linkage." In ASME 1993 Design Technical Conferences. American Society of Mechanical Engineers, 1993. http://dx.doi.org/10.1115/detc1993-0315.
Повний текст джерелаZhu, Liang, and David Kazmer. "An Extensive Simplex Method Mapping the Global Feasibility." In ASME 2002 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2002. http://dx.doi.org/10.1115/detc2002/dac-34115.
Повний текст джерелаKazmer, David, and Liang Zhu. "An Integrated Performance Modeling System." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-59100.
Повний текст джерелаPandey, Vijitashwa, Zissimos P. Mourelatos, and Matthew P. Castanier. "Decision Topology Assessment in Engineering Design Under Uncertainty." In ASME 2014 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/detc2014-34244.
Повний текст джерелаShao, Yufen, Jizhou Li, Ming–Jung Seow, Yuzixuan Zhu, Yuanyuan Guo, Daman Pradhan, Deepak Malpani, and Kevin Furman. "Integrated Concept Analytics and Development Optimization Under Uncertainties." In ADIPEC. SPE, 2022. http://dx.doi.org/10.2118/211442-ms.
Повний текст джерелаCarnero, María Carmen. "Selección de Aplicación para Gamificación en una Asignatura de los Grados en Ingeniería Eléctrica y Electrónica Industrial y Automática." In INNODOCT 2019. Valencia: Universitat Politècnica de València, 2019. http://dx.doi.org/10.4995/inn2019.2019.10252.
Повний текст джерелаЗвіти організацій з теми "Lineage decision"
Strichman, Ofer. Optimizations in Decision Procedures for Propositional Linear Inequalities. Fort Belvoir, VA: Defense Technical Information Center, May 2002. http://dx.doi.org/10.21236/ada461194.
Повний текст джерелаSadigh, Dorsa, Eric Kim, Samuel Coogan, S. S. Sastry, and Sanjt A. Seshia. A Learning Based Approach to Control Synthesis of Markov Decision Processes for Linear Temporal Logic Specifications. Fort Belvoir, VA: Defense Technical Information Center, September 2014. http://dx.doi.org/10.21236/ada623517.
Повний текст джерелаHoffmann, Bridget, and Juan Pablo Rud. Exposure and Income: Preliminary Findings on Labor Supply on High Pollution Days. Inter-American Development Bank, November 2021. http://dx.doi.org/10.18235/0003760.
Повний текст джерелаBorgwardt, Stefan, and Barbara Morawska. Finding Finite Herbrand Models. Technische Universität Dresden, 2011. http://dx.doi.org/10.25368/2022.182.
Повний текст джерелаHoffmann, Bridget, and Juan Pablo Rud. Open configuration options Exposure or Income? The Unequal Effects of Pollution on Daily Labor Supply. Inter-American Development Bank, February 2022. http://dx.doi.org/10.18235/0004003.
Повний текст джерелаPerdigão, Rui A. P. New Horizons of Predictability in Complex Dynamical Systems: From Fundamental Physics to Climate and Society. Meteoceanics, October 2021. http://dx.doi.org/10.46337/211021.
Повний текст джерелаHow Linear Thinking in a Non-Linear World Leads to Wrong Decisions. IEDP Ideas for Leaders, November 2017. http://dx.doi.org/10.13007/685.
Повний текст джерела