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Статті в журналах з теми "Life change events Physiological effect"
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Glaeser, Sharon S., Katie L. Edwards, Nadja Wielebnowski, and Janine L. Brown. "Effects of physiological changes and social life events on adrenal glucocorticoid activity in female zoo-housed Asian elephants (Elephas maximus)." PLOS ONE 15, no. 11 (November 6, 2020): e0241910. http://dx.doi.org/10.1371/journal.pone.0241910.
Повний текст джерелаАнотація:
Ensuring good health and welfare is an increasingly important consideration for conservation of endangered species and includes breeding of individuals managed under human care. Understanding how factors in the captive environment affect individual animal wellbeing can be aided by long-term monitoring of biological functioning. This study involved longitudinal assessments (4 to 28 years) of reproductive and adrenal hormones in zoo-housed female Asian elephants (Elephas maximus) (age range 4 to ~71 years) to elucidate patterns in adrenal glucocorticoid (GC) activity in association with reproductive and demographic factors, and examine individual response to major social changes. Concentrations of serum and urinary cortisol covaried more consistently with physiological changes (ovarian cycle phase, puberty, pregnancy, lactational anestrus, and age) than with social life events (births, deaths, and facility transfers). Cortisol fluctuated across the ovarian cycle with mean concentrations being higher in the follicular than in the luteal phase, and concentrations were highest in lactational anestrous compared to all other reproductive states. The elephants in this study exhibited substantial individuality in adrenal GC response to major social change, reinforcing the need to assess welfare on an individual basis and to consider factors influencing the impact of perceived stressors, such as social relationships, social support, temperament, and life history. Outcomes from this study deepen our understanding of Asian elephant physiology and highlight the importance of taking intrinsic patterns of hormone secretion into account when evaluating the impact of external factors. Finally, a better understanding of the impact of social change and resiliency in response to real and perceived stressors allows us to improve social management to enhance welfare in both captive settings and free-ranging environments.
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Bernhardt, Joey R., Mary I. O'Connor, Jennifer M. Sunday, and Andrew Gonzalez. "Life in fluctuating environments." Philosophical Transactions of the Royal Society B: Biological Sciences 375, no. 1814 (November 2, 2020): 20190454. http://dx.doi.org/10.1098/rstb.2019.0454.
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Variability in the environment defines the structure and dynamics of all living systems, from organisms to ecosystems. Species have evolved traits and strategies that allow them to detect, exploit and predict the changing environment. These traits allow organisms to maintain steady internal conditions required for physiological functioning through feedback mechanisms that allow internal conditions to remain at or near a set-point despite a fluctuating environment. In addition to feedback, many organisms have evolved feedforward processes, which allow them to adjust in anticipation of an expected future state of the environment. Here we provide a framework describing how feedback and feedforward mechanisms operating within organisms can generate effects across scales of organization, and how they allow living systems to persist in fluctuating environments. Daily, seasonal and multi-year cycles provide cues that organisms use to anticipate changes in physiologically relevant environmental conditions. Using feedforward mechanisms, organisms can exploit correlations in environmental variables to prepare for anticipated future changes. Strategies to obtain, store and act on information about the conditional nature of future events are advantageous and are evidenced in widespread phenotypes such as circadian clocks, social behaviour, diapause and migrations. Humans are altering the ways in which the environment fluctuates, causing correlations between environmental variables to become decoupled, decreasing the reliability of cues. Human-induced environmental change is also altering sensory environments and the ability of organisms to detect cues. Recognizing that living systems combine feedback and feedforward processes is essential to understanding their responses to current and future regimes of environmental fluctuations. This article is part of the theme issue ‘Integrative research perspectives on marine conservation’.
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LESERMAN, J., J. M. PETITTO, H. GU, B. N. GAYNES, J. BARROSO, R. N. GOLDEN, D. O. PERKINS, J. D. FOLDS, and D. L. EVANS. "Progression to AIDS, a clinical AIDS condition and mortality: psychosocial and physiological predictors." Psychological Medicine 32, no. 6 (August 2002): 1059–73. http://dx.doi.org/10.1017/s0033291702005949.
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Background. The primary aim of this study is to examine prospectively the association of stressful life events, social support, depressive symptoms, anger, serum cortisol and lymphocyte subsets with changes in multiple measures of human immunodeficiency virus (HIV) disease progression.Methods. Ninety-six HIV-infected gay men without symptoms or anti-retroviral medication use at baseline were studied every 6 months for up to 9 years. Disease progression was defined in three ways using the Centers for Disease Control (CDC) classifications (e.g. AIDS, clinical AIDS condition and mortality). Cox regression models with time-dependent covariates were used, adjusting for control variables (e.g. race, age, baseline, CD4 T cells and viral load, number of anti-retroviral medications).Results. Higher cumulative average stressful life events and lower cumulative average social support predicted faster progression to both the CDC AIDS classification and a clinical AIDS condition. Higher anger scores and CD8 T cells were associated with faster progression to AIDS, and depressive symptoms were associated with faster development of an AIDS clinical condition. Higher levels of serum cortisol predicted all three measures of disease progression.Conclusions. These results suggest that stressful life events, dysphoric mood and limited social support are associated with more rapid clinical progression in HIV infection, with serum cortisol also exerting an independent effect on disease progression.
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Meylan, Sandrine, Donald B. Miles, and Jean Clobert. "Hormonally mediated maternal effects, individual strategy and global change." Philosophical Transactions of the Royal Society B: Biological Sciences 367, no. 1596 (June 19, 2012): 1647–64. http://dx.doi.org/10.1098/rstb.2012.0020.
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A challenge to ecologists and evolutionary biologists is predicting organismal responses to the anticipated changes to global ecosystems through climate change. Most evidence suggests that short-term global change may involve increasing occurrences of extreme events, therefore the immediate response of individuals will be determined by physiological capacities and life-history adaptations to cope with extreme environmental conditions. Here, we consider the role of hormones and maternal effects in determining the persistence of species in altered environments. Hormones, specifically steroids, are critical for patterning the behaviour and morphology of parents and their offspring. Hence, steroids have a pervasive influence on multiple aspects of the offspring phenotype over its lifespan. Stress hormones, e.g. glucocorticoids, modulate and perturb phenotypes both early in development and later into adulthood. Females exposed to abiotic stressors during reproduction may alter the phenotypes by manipulation of hormones to the embryos. Thus, hormone-mediated maternal effects, which generate phenotypic plasticity, may be one avenue for coping with global change. Variation in exposure to hormones during development influences both the propensity to disperse, which alters metapopulation dynamics, and population dynamics, by affecting either recruitment to the population or subsequent life-history characteristics of the offspring. We suggest that hormones may be an informative index to the potential for populations to adapt to changing environments.
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Cohen, Miri, Liora Sklair-Tavron, and Shimon Pollack. "The Association of Forskolin-Stimulated Cyclic AMP Levels in Peripheral Blood Mononuclear Cells of Healthy People with Depressive Mood and Sense of Coherence." Journal of Psychophysiology 18, no. 4 (January 2004): 177–83. http://dx.doi.org/10.1027/0269-8803.18.4.177.
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Abstract: Background: Depressive mood exerts a suppressive effect on immune functions, mediated through neuro-immune processes. Research suggests a protective effect of sense of coherence (SOC) on psychological and physical health in face of stressful life events. Cyclic adenosine monophosphate (cAMP) is a cellular second messenger that is coupled to certain receptors expressed on peripheral blood mononuclear cells (PBMC). By interfering with the neuro-endocrine-immune axis, depressive mood may induce changes in intracellular cAMP levels in PBMC. Aims of study: To examine a possible association of SOC, stressful life events during the previous year, depressive mood, and cAMP levels. Methods: Fifteen male volunteers participated in the study. They completed the SOC and Zung's depression questionnaires and stressful life events inventory. Basic cAMP level and forskolin-stimulated cAMP production were measured in PBMC. Results: Forskolin-stimulated cAMP production was significantly higher in individuals who reported higher depressive mood, more stressful life events, or lower SOC scores. SOC scores explained 40% of forskolin-stimulated cAMP production. Basal cAMP levels could not be correlated with psychological scores. Age or education level did not affect forskolin-stimulated or basal cAMP levels. Conclusions: Our data suggest that high forskolin-stimulated cAMP production in PBMC is associated with low SOC, which points to availability of personal resources for coping with stressful life events. Further examination of the possible mediating role of SOC in relation to depressive mood and neuroimmune functions is needed.
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Martinez, J., and S. Merino. "Host-parasite interactions under extreme climatic conditions." Current Zoology 57, no. 3 (June 1, 2011): 390–405. http://dx.doi.org/10.1093/czoolo/57.3.390.
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Abstract The effect that climatic changes can exert on parasitic interactions represents a multifactor problem whose results are difficult to predict. The actual impact of changes will depend on their magnitude and the physiological tolerance of affected organisms. When the change is considered extreme (i.e. unusual weather events that are at the extremes of the historical distribution for a given area), the probability of an alteration in an organisms’ homeostasis increases dramatically. However, factors determining the altered dynamics of host-parasite interactions due to an extreme change are the same as those acting in response to changes of lower magnitude. Only a deep knowledge of these factors will help to produce more accurate predictive models for the effects of extreme changes on parasitic interactions. Extreme environmental conditions may affect pathogens directly when they include free-living stages in their life-cycles and indirectly through reduced resource availability for hosts and thus reduced ability to produce efficient anti-parasite defenses, or by effects on host density affecting transmission dynamics of diseases or the frequency of intraspecific contact. What are the consequences for host-parasite interactions? Here we summarize the present knowledge on three principal factors in determining host-parasite associations; biodiversity, population density and immunocompetence. In addition, we analyzed examples of the effects of environmental alteration of anthropogenic origin on parasitic systems because the effects are analogous to that exerted by an extreme climatic change.
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Uddin, Md Nagim, Tutul Kumar Saha, Myiesha Rayzil Hossain, SM Fakrul Islam, and Zakir Hossain. "Constraints to climate change adaptation and livelihood challenges: perspectives from the Sundarbans fishers' community in Bangladesh." Asian Journal of Medical and Biological Research 8, no. 2 (June 26, 2022): 103–14. http://dx.doi.org/10.3329/ajmbr.v8i2.60083.
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Fishers' are first-line observers of changes in the Sundarbans region and are among the first to be affected by the changes that occurred. In the Sundarbans fishers' communities, transformations of society have always been a part of life. In contrast, environmental changes were always interim and reversible, allowing them to understand and identify with the Sundarbans ecosystems as food and life providers. In this study, fishers' observations on climate change impacts and their livelihoods were compiled and analysed using a structured questionnaire in accordance with the tenets of grounded theory. The observations of fishers from the region of the Sundarbans demonstrated a rise in the frequency of extreme weather events caused by rising temperatures and changes in the weather pattern. Physical components such as rainfall, coastal erosion, sea-level rise, siltation alterations in fish species distribution ranges, and migratory spawning behaviours were also affected by changes in the region's weather and climate. As salinity levels rose, the diversity and productivity of river ecosystems were affected, particularly in the most vulnerable areas. As a result, river freshwater flow decreased over time. A high rate of siltation in rivers and river mouths was considered another major concern that led to seasonal flooding due to its low freshwater upstream flow rate. The Sundarbans region provides a vast array of resources for diversifying fishers' livelihoods, but climate change is diminishing these alternatives due to more frequent catastrophic events. Specifically, climate change limits the resilience of fishers' communities, restricting opportunities for diversification or forcing them to leave their homes or villages. Climate change generated an environment that was generally unfavourable for all fishing communities. In order to survive in an unfavourable environment, the social well-being of fishers (mostly women and children) was negatively impacted by a variety of challenges, including disease, lack of potable water, malnutrition, sanitary difficulties, lack of electricity, lack of food and clothing, lack of proper medical care, and so on. To evaluate the effects of climate change on fisheries in the study area, the biodiversity, abundance, and production of most freshwater species are drastically reduced due to the destruction of spawning grounds, a transition in the spawning season, and the obstruction of fish migration. The findings of this study show that the climate and livelihood conditions of fishers in the Sundarbans region have changed significantly over the past few decades. Regardless of GOs and NGOs taking the required steps, proper implementation of interdisciplinary adaptive policy and regular monitoring in the Sundarbans fisher's community in Bangladesh could effectively reduce climate change impacts and improve livelihood conditions. Asian J. Med. Biol. Res. 2022, 8 (2), 103-114
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van Halem, Sjoerd, Eeske van Roekel, Lara Kroencke, Niclas Kuper, and Jaap Denissen. "Moments that Matter? On the Complexity of using Triggers Based on Skin Conductance to Sample Arousing Events within an Experience Sampling Framework." European Journal of Personality 34, no. 5 (September 2020): 794–807. http://dx.doi.org/10.1002/per.2252.
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To sample situations that are psychologically arousing in daily life, we implemented an experience sampling strategy in which 82 Dutch young adults ( Mage = 20.73) were triggered based on random time intervals and based on physiological skin conductance scores across a period of 5 days. When triggered, participants had to fill in short surveys on affect, situational characteristics and event characteristics on their smartphone. We found theoretically expected relationships between the skin conductance signal on the one hand and self–reported arousal and positive energy (e.g. energetic and enthusiastic) on the other hand, although effect sizes were small. Unexpectedly, none of the negative affective scales (i.e. irritation, anxiety, and negative valence) were predicted by skin conductance levels. Despite the (partial) validity of the signal, a simple algorithm that triggered the survey based on relative increases of skin conductance levels produced counterintuitive results due to a dependence between level and slope. Additional exploratory analyses highlighted other skin conductance signal characteristics (i.e. autocorrelation, number of peaks, and change points) that might be worth examining when designing future algorithms to sample arousing moments. Overall, our experiences highlight not only the promise but also the complexity of real–time measurement of physiological processes in daily life. © 2020 The Authors. European Journal of Personality published by John Wiley & Sons Ltd on behalf of European Association of Personality Psychology
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Glaeser, Sharon S., Katie L. Edwards, Stephen Paris, Candace Scarlata, Bob Lee, Nadja Wielebnowski, Shawn Finnell, Chaleamchat Somgird, and Janine L. Brown. "Characterization of Longitudinal Testosterone, Cortisol, and Musth in Male Asian Elephants (Elephas maximus), Effects of Aging, and Adrenal Responses to Social Changes and Health Events." Animals 12, no. 10 (May 23, 2022): 1332. http://dx.doi.org/10.3390/ani12101332.
Повний текст джерелаАнотація:
The conservation of endangered species and sustainability of managed populations requires considerations to ensure the health and welfare of individuals. Male elephants experience a biological phenomenon called “musth”, which is characterized by increased testosterone production, temporal gland secretion and urine dribbling, heightened aggression and sexual behavior, and therefore can pose unique challenges for human safety and animal welfare. This study characterized longitudinal (9 to 22 years) patterns of circulating testosterone and cortisol in relation to musth in four adult Asian elephant bulls spanning ages from 12 to 54 years. Age-related effects on musth activity and adrenal responses to social changes and clinical health events were also examined. All bulls exhibited regular annual musth cycles. Circulating cortisol covaried positively with testosterone and musth, highlighting intrinsic patterns that should be considered when evaluating the impact of social, health, and environmental changes on adrenal glucocorticoid activity. Except for an end-of-life cortisol increase in one bull, there was no clear evidence of chronically elevated cortisol secretion outside of musth in any individual. Testosterone decreased with age in sexually mature bulls, whereas age-related changes in cortisol varied across individuals, with the three older bulls showing the greatest rate of change during musth versus inter-musth periods. In contrast to physiological factors, there was no evidence of social factors, such as addition of a new male and death of male herdmates, impacting adrenal glucocorticoid activity in these bulls in the short term. Changes in cortisol were associated with treatment for Mycobacterium tuberculosis (M. tb) in two bulls, increasing after start of treatment and decreasing with cessation of treatment, but were not clearly associated with activation of disease. This study highlights the importance of longitudinal hormone monitoring to track changes in physiological function and responses to social, health, and environmental change in elephant bulls, which is important for making more informed decisions on how to manage male elephants under varying degrees of human care to ensure welfare and safety.
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Gunderson, Alex R., Amélie Fargevieille, and Daniel A. Warner. "Egg incubation temperature does not influence adult heat tolerance in the lizard Anolis sagrei." Biology Letters 16, no. 1 (January 2020): 20190716. http://dx.doi.org/10.1098/rsbl.2019.0716.
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Extreme heat events are becoming more common as a result of anthropogenic global change. Developmental plasticity in physiological thermal limits could help mitigate the consequences of thermal extremes, but data on the effects of early temperature exposure on thermal limits later in life are rare, especially for vertebrate ectotherms. We conducted an experiment that to our knowledge is the first to isolate the effect of egg (i.e. embryonic) thermal conditions on adult heat tolerance in a reptile. Eggs of the lizard Anolis sagrei were incubated under one of three fluctuating thermal regimes that mimicked natural nest environments and differed in mean and maximum temperatures. After emergence, all hatchlings were raised under common garden conditions until reproductive maturity, at which point heat tolerance was measured. Egg mortality was highest in the warmest treatment, and hatchlings from the warmest treatment tended to have greater mortality than those from the cooler treatments. Despite evidence that incubation temperatures were stressful, we found no evidence that incubation treatment influenced adult heat tolerance. Our results are consistent with a low capacity for organisms to increase their physiological heat tolerance via plasticity, and emphasize the importance of behavioural and evolutionary processes as mechanisms of resilience to extreme heat.
Дисертації з теми "Life change events Physiological effect"
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Price, Simani Mohapatra. "The effect of rumination on beliefs about adjustment to future negative life events." Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-08182009-040525/.
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Shiau, Shujen. "The mediating effect of maternal-child coping behaviors on child adaptational outcome : an ecological approach /." Thesis, Connect to this title online; UW restricted, 1989. http://hdl.handle.net/1773/7349.
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Graham, Neil M. H. (Neil Murray Hamilton). "Psychosocial factors in the epidemiology of acute respiratory infection." 1987. http://web4.library.adelaide.edu.au/theses/09MD/09mdg741.pdf.
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Graham, Neil M. H. (Neil Murray Hamilton). "Psychosocial factors in the epidemiology of acute respiratory infection." Thesis, 1987. http://hdl.handle.net/2440/38315.
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Matson, Liana M. "Investigating reactivity to incentive downshift as a correlated response to selection for high alcohol preference and a determinant of rash action and alcohol consumption." Thesis, 2014. http://hdl.handle.net/1805/5964.
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Indiana University-Purdue University Indianapolis (IUPUI)Losing a job or a significant other are examples of incentive shifts that result in negative emotional reactions. The occurrence of negative life events is associated with increased drinking, and alleviation of negative emotions has been cited as a drinking motive for individuals with problematic drinking patterns (Keyes et al., 2011; Adams et al., 2012). Further, there is evidence that certain genotypes drink alcohol in response to stressful negative life events (Blomeyer et al., 2008; Covault et al., 2007). It is possible that shared genetic factors contribute to both alcohol drinking and emotional reactivity, but there is a critical need for this relationship to be understood. The first aim of this proposal will use an incentive downshift paradigm to address whether emotional reactivity is elevated in mice predisposed to drink alcohol. The second aim of this proposal will address if reactivity to an incentive shift can result in rash action using a differential reinforcement of low rates of responding task, and whether this response is also associated with a predisposition for high drinking. The third aim of this proposal will investigate if experimenter administered ethanol reduces contrast effects, and if an incentive shift increases ethanol consumption in a high drinking line. The overall goal of this proposal is to investigate whether reactivity to incentive shift is an important mechanism underlying alcohol drinking in these mice, and the role an incentive shift may play in producing rash action and influencing ethanol consumption.
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Friedman, Beverly. "The effect of contextual and historical factors on post-traumatic stress in car-hijacking." Thesis, 2014. http://hdl.handle.net/10210/12075.
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Kotzé, Esté. "Die algemene weerstandsbronne van vroue wie se mans buite-egtelike verhoudings gehad het." Thesis, 2012. http://hdl.handle.net/10210/7429.
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M.A.This study uses the salutogenic model as a departure point to focus on the sense of coherence (SOC) of women who had to overcome a crisis. Stressors come in many forms but this study focuses specifically on the husband's extramarital affair. After (or during) the initial shock the woman has to make a decision regarding her marriage. Women were considered in regard to the decisions they made, namely to stay in the marriage or to leave it. The first hypothesis stated that the SOC of the women who decided to leave the relationship would be higher than that of the other group. The second hypothesis stated that there would be differences amongst the three components of the SOC (meaningfulness, manageability and comprehension) for the two groups. Meaningfulness would measure higher for the group that decided to end their marriages. Manageability and comprehension would measure higher for the group that decided to stay in their marriages. These different components were quantitatively measured using Antonovsky's SOC-scale. A biographical questionnaire and a qualitative question regarding the reason for the decision that was made, was also included. Although the two hypotheses were not supported, important findings did emerge from the study. The women that left their marriages were found to be more satisfied with their decision than the other group. Women's SOC who felt satisfied or very satisfied with their decision measured higher than those that felt neutral, dissatisfied or very dissatisfied with their decision. This suggests that it is more important that women make decisions that are congruent with their values and views of the marriage, than whether the decision was to terminate or continue with the marriage. This could be valuable information for practitioners working in the field. In addition, it was also found that women who got married at 22 years or older, had a higher SOC than women who got married before they were 22. This suggests that SOC continues to develop with maturity and challenges the notion that SOC ceases to develop into adulthood. Future longitudinal research covering the changes of SOC during the lifespan of a relationship would probably shed light on this issue.
Книги з теми "Life change events Physiological effect"
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Quand les sombres nuages persistent: Conseils du coeur à ceux qui vivent des moments difficiles et à ceux qui les aiment. Boucherville, Quebec: De Mortagne, 2011.
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Buchwald, Petra, Tobias Ringeisen, and Kathleen A. Moore. Stress and anxiety: Application to education and health. Berlin: Logos Verlag Berlin, 2011.
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Buchwald, Petra, Kathleen A. Moore, and Krzysztof Kaniasty. Stress and anxiety: Application to economic hardship, occupational demands, and developmental challenges. Berlin: Logos, 2012.
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Buchwald, Petra, Kathleen A. Moore, Krzysztof Kaniasty, and Albert Sesé. Stress and anxiety: Applications to health and well-being, work stressors, and assessment. Berlin: Logos Verlag Berlin, 2013.
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Deschênes, Olivier. Extreme weather events, mortality and migration. Cambridge, Mass: National Bureau of Economic Research, 2007.
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The Ripple Effect: Our Harvest. Onjinjinkta Publishing, 1999.
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Eadie, Betty J. The Ripple Effect: Our Harvest. Onjinjinkta Publishing, 1999.
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Grace, Annie. This naked mind: Control alcohol, find freedom, discover happiness & change your life. 2018.
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Davis, Marli. Quit Smoking and Stay Quit: Discover a New Way to Change (New Life Guides, Helping People to Change). MCJ Global Resources, 2003.
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1961-, Buchwald Petra, Ringeisen Tobias, and Eysenck Michael W, eds. Stress and anxiety: Application to life span development and health promotion. Berlin: Logos, 2008.
Знайти повний текст джерелаЧастини книг з теми "Life change events Physiological effect"
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Dunsmoor, Joseph E., and Marijn C. W. Kroes. "Emotion–Memory Interactions." In Neuroscience of Enduring Change, 132–62. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190881511.003.0006.
Повний текст джерелаАнотація:
Emotional events are better remembered with more vividness and confidence than everyday occurrences. This prioritization of emotional events in memory can be helpful by ensuring that we remember important information associated with meaningful events. But persistent and intrusive memories of negative experiences presents a burden to daily life, exemplified in anxiety and stress disorders, such as posttraumatic stress disorder. Here, we describe emerging cognitive neuroscience research detailing how emotion shapes learning and memory. This research is framed in a historical context of pioneering studies in laboratory animals on Pavlovian fear conditioning and the role of stress and arousal on memory formation. Translating advances in the neuroscience of learning and memory from rodents to humans has opened the way for several lines of research that may ultimately lead to a better understanding and innovative treatments for mental health disorders. This includes new insights on how memory might be persistently attenuated so as to diminish the psychological and physiological effects of unwanted emotional memories.
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West-Eberhard, Mary Jane. "Heterochrony." In Developmental Plasticity and Evolution. Oxford University Press, 2003. http://dx.doi.org/10.1093/oso/9780195122343.003.0019.
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Heterochrony is evolutionary change in the timing of expression of a phenotype trait, that transfers expression of the trait from one life stage or behavioral or physiological phase to another—”the shifting of characters from one part of an ontogeny to another” (Valentine, 1977b, p. 260) or simply “the displacement of characters in time” (Gould, 1977, p. 225). A clear fossil example occurs in monograptids, where there is a temporal shift in the onset of a modified morphology, a life-history modification that is recorded in the structure of the body (figure 13.1). Heterochrony can occur at any level of organization, including the molecular level, where evolutionary changes in the timing of gene expression have been demonstrated, for example, in echinoids and a fibronectin gene of amphibians (Collazo, 1994). Some recent authors (e.g., McKinney and McNamara, 1991; Reilly et al., 1997) define heterochrony as any change in the timing of regulatory events. Most novel traits qualify as heterochrony by this regulatory-timing definition, since virtually all evolutionary change involves change in the timing of developmental events. This regulatorytiming definition of heterochrony leads to a classification of evolutionary change termed panheterochrony by McKinney and McNamara (1991)—a classification of evolutionary transitions that lumps all evolutionary change under the heading of heterochrony. “Because all developmental events occur along a time line, any significant change is likely to result in a heterochrony at some level” (Raff, 1992, p. 211). As expressed by Barbara McClintock in a staff meeting at Cold Spring Harbor Laboratories, “If I could control the time of gene action, I could cause a fertilized snail egg to develop into an elephant. Their biochemistries are not all that different; it's simply a matter of timing”. I will adhere to a classification that divides the effects of regulatory change into their different kinds of effects on phenotypes, in keeping with the general emphasis on phenotypes in this book.
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Tatar, Marc. "Senescence." In Evolutionary Ecology. Oxford University Press, 2001. http://dx.doi.org/10.1093/oso/9780195131543.003.0015.
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At all taxonomic levels, there exists tremendous variation in life expectancy. A field mouse Peromyscus may live 1.2 years, while the African elephant may persist for 60 years, and even a mousesized bat such as Corynorhinus rafinesquei lives a healthy 20 years (Promislow 1991). Part of this variance is caused by differences in ecological risks, rodents being perhaps the most susceptible to predation, and to vagaries of climate and resources. Another portion is caused by differences in senescence, the intrinsic degeneration of function that produces progressive decrement in age-specific survival and fecundity. Senescence occurs in natural populations, where it affects life expectancy and reproduction as can be seen, for instance, from the progressive change in age-specific mortality and maternity of lion and baboon in East Africa. The occurrence of senescence and of the widespread variation in longevity presents a paradox: How does the age-dependent deterioration of fitness components evolve under natural selection? The conceptual and empirical resolutions to this problem will be explored in this chapter. We shall see that the force of natural selection does not weigh equally on all ages and that there is therefore an increased chance for genes with late-age-deleterious effects to be expressed. Life histories are expected to be optimized to regulate intrinsic deterioration, and in this way, longevity evolves despite the maladaptive nature of senescence. From this framework, we will then consider how the model is tested, both through studies of laboratory evolution and of natural variation, and through the physiological and molecular dissection of constraints underlying trade-offs between reproduction and longevity. As humans are well aware from personal experience, performance and physical condition progressively deteriorate with adult age. And in us, as well as in many other species, mortality rates progressively increase with cohort age. Medawar (1955), followed by Williams (1957), stated the underlying assumption connecting these events: Senescent decline in function causes a progressive increase in mortality rate. Although mortality may increase episodically across some age classes, such as with increases in reproductive effort, we assume that the continuous increase of mortality across the range of adult ages represents our best estimate of senescence.
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de Berker, David. "Hair and nail disorders." In Oxford Textbook of Medicine, edited by Roderick J. Hay, 5724–31. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0562.
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Nails grow continuously throughout life, except after exceptional physiological or traumatic events when they are shed. All other less disruptive influences result in changes in the colour, thickness, texture, and growth of nails, and may also affect the periungual tissues. The most common local diseases affecting the nail are psoriasis, fungal nail infections, periungual eczema, and viral warts. Trauma is a common cause of changes in toenails. Disease can affect hair growth by direct action on the follicle or by indirect effects sustained through generalized physiological disturbance. Clinicians might be asked to assess specific diseases of the scalp with implications for hair growth, or specifically to address pathological patterns of hair growth where there may be underlying systemic disease. Common diseases of the scalp include psoriasis, eczema, fungal infection, alopecia areata, and the scarring alopecias.
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Shafer, Krystle, and Marie R. Baldisseri. "Neurocritical Care in Pregnancy." In Neurocritical Care, edited by Samuel A. Tisherman and Sara Hefton, 247–55. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199375349.003.0023.
Повний текст джерелаАнотація:
Pregnancy results in physiologic changes that bring added stress to the body. Changes in cardiovascular hemodynamics, respiratory physiology, coagulation profile, hormonal concentrations, and endothelial function can result in the perfect storm for cerebrovascular dysfunction. Cerebrovascular disorders of pregnancy can be grossly simplified to disorders that arise from thrombosis, hemorrhage, and/or hypertension. Care of these patients become more complex when considering the effects of therapy on the fetus. The age of the fetus comes into play as well as pharmacologic agents that cross the placenta and may potentially harm the fetus. Ultimately, the priority for the clinician is to provide life-saving care to the patient even if it is at the expense of the fetus. In rare cases where despite best medical management practices the patient develops brain death or is vegetative, the decision to continue life support to allow further development of the fetus becomes an ethically complex situation.
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Kukulska-Hulme, Agnes. "Language Change." In Language and Communication. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780195108385.003.0009.
Повний текст джерелаАнотація:
• Are computer applications changing our language? • Why do some people reject technology? • Are adults willing to change their language? • Do other cultures want to borrow English computing terms? • Is our knowledge of word meanings out of date? . . . In this chapter on language change, we address these questions first by examining the reasons for change and looking at the various types of change that can occur. We then focus on developments in the language of adults (life-long language learning) and on how language is organized in the minds of speakers. We consider people’s expectations with regard to meanings as well as the process of acquiring new words and meanings. The final part of the chapter deals with the issue of borrowing words from other languages. No one really knows why languages change over time, though a number of possible explanations have been put forward concerning specific instances of change. Historical events can sometimes provide explanations, when new contact or loss of contact between groups of people is eventually reflected in the word stock or sounds of a language. It is interesting to speculate whether electronic contact (e.g., through the Internet) might have the same degree of power to change languages over time. Certainly, in that environment, as in the “real world,” social forces can be observed: Borrowing words from another language and integrating them into one’s own can be part of a process of wanting to imitate another culture—especially one that is seen to be more fashionable or more technologically advanced. If new objects, ideas, and processes have to be named, new words will appear; similarly, old ones will fall out of use. Technological advancements contribute to these needs. They also create new human communication environments, which require new forms of text or speech, which in turn have an effect on the language to be used.
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Bonura, Sandra E. "Introduction." In Light in the Queen's Garden. University of Hawai'i Press, 2017. http://dx.doi.org/10.21313/hawaii/9780824866440.003.0001.
Повний текст джерелаАнотація:
Great historical events often accompany great forces of nature: a hurricane, a tsunami, an avalanche. Traced back to their origins, such natural cataclysms start as a gentle breeze, a single drop of rain, a small pebble falling. They appear harmless, but trigger life-changing events. Similarly, a swath of Hawaiian history can be traced directly to an unassuming woman from Ohio who set into motion a series of events that would ultimately effect social change for Hawaiian women....
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Fink MD, Max. "What Is Electroconvulsive Therapy?" In Electroconvulsive Therapy. Oxford University Press, 2010. http://dx.doi.org/10.1093/oso/9780195365740.003.0005.
Повний текст джерелаАнотація:
Electroconvulsive therapy (ECT) is an effective medical treatment for severe and persistent psychiatric disorders. It relieves de pressed mood and thoughts of suicide, as well as mania, acute psychosis, delirium, and stupor. It is usually applied when medications have given limited relief or their side effects are intolerable. Electroconvulsive therapy is similar to a surgical treatment. It requires the specialized skills of a psychiatrist, an anesthesiologist, and nurses. The patient receives a short-acting anesthetic. While the patient is asleep, the physician, following a prescribed procedure, induces an epileptic seizure in the brain. By making sure that the patient’s lungs are filled with oxygen, the physician precludes the gasping and difficult breathing that accompany a spontaneous epileptic fit. By relaxing the patient’s muscles with chemicals and by inserting a mouth guard (not unlike those used in sports), the physician prevents the tongue biting, fractures, and injuries that occasionally occur in epilepsy. The patient is asleep, and so experiences neither the painful effects of the stimulus nor the discomforts of the seizure. The physiological functions of the body, such as breathing, heart rate, blood pressure, blood oxygen concentration, and degree of motor relaxation, are monitored, and anything out of the ordinary is immediately treated. Electroconvulsive therapy relieves symptoms more quickly than do psychotropic drugs. A common course of ECT consists of two or three treatments a week for two to seven weeks. To sustain the recovery, weekly or biweekly continuation treatments, either ECT or medications, are often administered for four to six months. If the illness recurs, ECT is prescribed for longer periods. The duration and course of ECT are similar to those of the psychotropic medicines frequently used for the same conditions. Electroconvulsive therapy has been used safely to treat emotional disorders in patients of all ages, from children to the elderly, in people with debilitating physical illnesses, and in pregnant women. Emotional disorders may be of short or long duration; they may be manifest as a single episode or as a recurring event. Electroconvulsive treatment is an option when the emotional disorder is acute in onset; when changes in mood, thought, and motor activities are pronounced; when the cause is believed to be biochemical or physiological; when the condition is so severe that it interferes with the patient’s daily life; or when other treatments have failed.
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Merhan, Oguz. "Biochemistry and Antioxidant Effects of Melatonin." In Melatonin - Recent Updates [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.106260.
Повний текст джерелаАнотація:
Melatonin (N-acetyl-5-methoxy-tryptamine) is a hormone taking place in many biological and physiological processes, such as reproduction, sleep, antioxidant effect, and circadian rhythm (biological clock), and is a multifunctional indolamine compound synthesized mainly from the metabolism of tryptophan via serotonin in the pineal gland. Melatonin, which is a hormone synthesized from the essential amino acid tryptophan, is substantially secreted from the pineal gland between the cerebral hemispheres found in the mammalian brain. In addition to this, it is also produced in the cells and tissues, such as the gastrointestinal system, gall, epithelial hair follicles, skin, retina, spleen, testis, salivary glands, bone marrow, leukocytes, placenta, and thrombocytes. It plays a role in many physiological events, such as synchronizing circadian rhythms, reproduction, fattening, molting, hibernation, and change of pigment granules, preserving the integrity of the gastrointestinal system with an anti-ulcerative effect in tissues and organs from which it is produced. Melatonin is also a powerful antioxidant and anti-apoptotic agent that prevents oxidative and nitrosative damage to all macromolecules due to its ability to form in metabolic activities, directly excrete toxic oxygen derivatives, and reduce the formation of reactive oxygen and nitrogen species. In this book chapter, we will explain the structure, synthesis, metabolism, and antioxidant effects of the melatonin hormone.
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Fernandes, Melissa, Vera Bernardino, Anna Taulaigo, Jorge Fernandes, Ana Lladó, and Fátima Serrano. "Systemic Lupus Erythematosus Pregnancy." In Lupus - Need to Know. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.99008.
Повний текст джерелаАнотація:
Systemic Lupus Erythematosus (SLE) is an autoimmune disease of unknown etiology that often affects women during childbearing age. Pregnant women with SLE are considered high-risk patients, with pregnancy outcomes being complicated by high maternal and fetal mortality and morbidity. Obstetric morbidity includes preterm birth, fetal growth restriction (FGR), and neonatal lupus syndromes. Active SLE during conception is a strong predictor of adverse pregnancy outcomes and exacerbations of disease can occur more frequently during gestation. Therefore, management of maternal SLE should include preventive strategies to minimize disease activity and to reduce adverse pregnancy outcomes. Patients with active disease at time of conception have increased risk of flares, like lupus nephritis, imposing a careful differential diagnosis of pre-eclampsia, keeping in mind that physiological changes of pregnancy may mimic a lupus flare. Major complications arise when anti-phospholipid antibodies are present, like recurrent pregnancy loss, stillbirth, FGR, and thrombosis in the mother. A multidisciplinary approach is hence crucial and should be initiated to all women with SLE at childbearing age with an adequate preconception counseling with assessment of risk factors for adverse maternal and fetal outcomes with a tight pregnancy monitoring plan. Although treatment choices are limited during pregnancy, prophylactic anti-aggregation and anticoagulation agents have proven beneficial in reducing thrombotic events and pre-eclampsia related morbidity. Pharmacological therapy should be tailored, allowing better outcomes for both the mother and the baby. Immunosuppressive and immunomodulators, must be effective in controlling disease activity and safe during pregnancy. Hydroxychloroquine is the main therapy for SLE due to its anti-inflammatory and immunomodulatory effects recommended before and during pregnancy and other immunosuppressive drugs (e.g. azathioprine and calcineurin inhibitors) are used to control disease activity in order to improve obstetrical outcomes. Managing a maternal SLE is a challenging task, but an early approach with multidisciplinary team with close monitoring is essential and can improve maternal and fetal outcomes.
Тези доповідей конференцій з теми "Life change events Physiological effect"
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You, Jun, Clare E. Yellowley, Henry J. Donahue, and Christopher R. Jacobs. "Physiological Levels of Substrate Deformation Are Less Stimulatory to Bone Cells Compared to Fluid Flow." In ASME 1999 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/imece1999-0427.
Повний текст джерелаАнотація:
Abstract It is believed that bone cells can sense mechanical loading and alter bone external shape and internal structure to efficiently support the load bearing demands placed upon it. However, the mechanism by which bone cells sense and respond to their mechanical environment is still poorly understood. In particular, the load-induced signals to which bone cells respond, e.g. fluid flow, substrate deformation, electrokinetic effects etc., are unclear. Furthermore, there are few studies focused on the effects of physiological strain (strain < 0.5%, Burr, 1996; Owan, 1997) on bone cells. The goal of this study was to investigate cytosolic Ca2+ mobilization (a very early signaling event) in response to different substrate strains (physiological or supra-physiological strains), and to distinguish the effects of substrate strain from those of fluid flow by applying precisely controlled strain without induced fluid flow. In addition, we quantified the effect of physiologically relevant fluid flow (Cowin, 1995) and substrate stretch on the expression of mRNA for the bone matrix protein osteopontin (OPN). A computer controlled stretch device was employed to apply different substrate strains, 0.1%, 1%, 5% and 10%. A parallel plate flow chamber was used to test cell responses to steady and oscillating flows (20dyn/cm2, 1Hz). Our data demonstrate that physiological strain (< 0.5%) does not induce [Ca2+]i responses in primary rat osteoblastic cells (ROB) in vitro. However, there was a significant (p < 0.05) increase in the number of responding cells at supra-physiological strains of 1, 5, and 10% suggesting that the cells were capable of a biological response. Similar results for human fetal osteoblastic cells (hFOB 1.19) and osteocyte-like cells (ML0-Y4) were obtained. Furthermore, compared to physiological substrate deformation, physiological fluid flow induced greater [Ca2+]i responses for hFOB cells, and these [Ca2+]i responses were quantitatively similar to those obtained for 10% substrate strain. Moreover we found no change in osteopontin mRNA expression after 0.5% strain stretch. Conversely, physiological oscillating flow (20dyn/cm2, 1Hz) caused a significant increase in osteopontin mRNA. These data suggest that, relative to fluid flow, substrate deformation may play less of a role in bone cell mechanotransduction.
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Uitterhoeve, Wendie, and Melcher Zeilstra. "Differences in Workload of Both Skippers and Pilots Due to Changes in Environmental Bank Lights." In Applied Human Factors and Ergonomics Conference. AHFE International, 2022. http://dx.doi.org/10.54941/ahfe100725.
Повний текст джерелаАнотація:
In the case a sea harbour is located in an inland area, seagoing vessels have to sail a part of their journey in inland waterways. On these approach channels the inland water regulation prescribes specific bridge equipment. Inland vessels fulfil this regulation, the seagoing vessels not, but get dispensation with a pilot on board. The question arises how differences in working strategy (resulting from different ship characteristics and equipment) express in differences in workload. The effect of changes in environmental bank lights (puddle lights) on both inland skippers and pilots is studied in a manoeuvring simulator using physiological workload measurements. Event analysis is based on a combination of analytical indicators (distance between vessels) and cognitive processes like interpreting perceived visual information. Results demonstrated that the effect of changes in puddle light is different for skippers and pilots. Differences in vessel and bridge settings are indeed expressed in working strategy and result in differences in workload. Inland skippers give effort to continuous steering corrections and are, compared to the pilots, less used to anticipate on future actions. In the absence of puddle light, the skippers mental spare capacity decreases clearly. Although the subjective opinion of the pilots indicate an increase of demand, the objective measures do not show a considerable increase.
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Chiu, Wei-Che, Yared Alemu, Bryan Lynch, Shmuel Einav, Marvin Slepian, and Danny Bluestein. "Comparative Studies of Axial Ventricular Assist Devices (VAD) and the Effect of Outflow Cannulation." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14102.
Повний текст джерелаАнотація:
Congestive heart failure has reached epidemic proportions in the United States with more than 5.7 million patients suffering from it annually ( 1). Due to the limited availability of donor hearts, patients in their late stage heart failure who may require cardiac transplantation are dying while waiting for a matched heart. Mechanical circulatory support devices (MCS), such as ventricular assist devices (VAD), are utilized as a bridge to transplantation, and recently as destination therapy for extending the life of these patients. Continuous-flow VAD offer a surgical advantage over older generation pulsatile-flow VAD due to their compact design; however, due to the high RPM these VADs are operated with and the non-physiological blood flow patterns they generates, VADs are burdened with high incidence of thromboembolic events, and antiplatelet/anticoagulation regimens are mandated for the device recipients.
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Camilleri, Lawrence, Arthur Watson, Yan Liu, and Mohammed El-Gindy. "Keep Your ESPs Running: Case Studies Exhibiting a Holistic Methodology for Run-Life Improvement." In SPE Gulf Coast Section Electric Submersible Pumps Symposium. SPE, 2021. http://dx.doi.org/10.2118/204483-ms.
Повний текст джерелаАнотація:
Abstract Build a more robust ESP or reduce the stress it endures? Run-life improvement requires finding the right balance to suit the local well conditions and economics. Utilizing key case studies, the paper examines how operational stress caused by low flow rates can be avoided with the correct utilization of instrumentation, surveillance, and automation thereby providing practical solutions for extending the run life of already installed ESPs. The method starts with an extensive review of ESP failure mechanisms and their causes, supported by case studies and pictures illustrating the symptoms that can be observed during dismantling. This holistic technique is supported by several case studies. The common "thread" found on most failure mechanisms is temperature rise inside the ESP, which deteriorates properties of materials, including polymer insulation, elastomer seals, and metallic parts. Heat rise is attributed to three main causes: motor thermal losses, pump hydraulic losses, and frictional heat. Case studies and data sets are provided to confirm that a paradigm shift in mitigation improvement can be achieved by automating the identification of low flow events utilizing a downhole real-time flowmeter. Three reasons are given. Firstly, it is a leading indicator, whereas surface flow meters and temperature sensors are lagging indicators due to pump-up time and heat exchange respectively. Secondly, automation enables more consistent and cost-effective identification in large ESP populations. Thirdly, it enables deeper diagnostics of the cause of low flow (i.e., gas lock versus slugging, and even the source of slugging such as horizontal lateral versus production tubing). The authors provide an exhaustive list of case studies identifying sand fallback and scale as well as low flow causes and how they can be diagnosed, including differentiation between ESP, wellbore hydraulics, and reservoir inflow causes (e.g. depletion and skin.) Over the last 30 years, improvements in design and materials have tripled ESP run lives. Therefore, many fields attain six-year average run lives and 90-day survivability of 98%. Nevertheless, economics have tightened, which has raised the bar, and therefore, many operators still suffer uneconomical run lives. Case studies indicate that the next step-change in run life improvement will require a reduction in environmental stresses by mitigating the effect of low-flow events, scale, and sand.
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GOLYASH, Iryna. "THE WAR AND HAPPINESS: SOCIO-ECONOMIC ASPECTS." In Proceedings of The Third International Scientific Conference “Happiness and Contemporary Society”. SPOLOM, 2022. http://dx.doi.org/10.31108/7.2022.15.
Повний текст джерелаАнотація:
Ukraine has felt the impact of strong force, which has affected the level of happiness in the country. The circumstances were military actions which was provoked by the aggression of the Russian Federation. A whole generation of people knew about the war only from historical sources and had no previous experience of survival. During the war, basic physiological needs became a priority for the civilian population of Ukraine: security, water, food, heat, sleep, medicine. All other needs of a higher order have ceased, or become to be inconsiderable. The war did not make people happy, but it changed their behavior, which was due to the need to make important current and future decisions. Current decisions focused on survival, while long-term decisions focused on choosing one of the alternative life options, taking into account its expected quality and subjective prediction of personal happiness and happiness of their children. All this has led to a number of transformations in the socio-economic sphere, such as: falling incomes and rising household expenditures; change in the structure of consumption; shortage of certain foods and medicines; the impact of inflation; intensification of migration processes; demographic disparities and family separation; reduction of human resources; reduction of life expectancy and deterioration of health of Ukrainians; limited transport and logistics within the country; termination of a significant part of enterprises and small businesses; heavy load on social infrastructure facilities; increasing the number of individuals and families in difficult life circumstances, etc. According to the Phoenix Effect, life is expected to recover very quickly after the war. Ukrainians, having gone through numerous trials, will become much more resilient and happier in the future. Key words: Ukraine, russia, war, happiness, sconomy, Society, future
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Prasad, P. Anil, and Naveen Kumar M. "Management of Lifelong Learning: from Individuals to Learning Organizations and Societies." In Tenth Pan-Commonwealth Forum on Open Learning. Commonwealth of Learning, 2022. http://dx.doi.org/10.56059/pcf10.1990.
Повний текст джерелаАнотація:
Learning is the core competency required by the human beings, all living things, and even half-organisms like viruses, to survive in this world. Learning continues throughout one's life. When learning stops, it is almost the end of life. This fact remains explicit for anyone who observes life closely. Review of literature on progresses, innovations and overall successes of individuals, societies and organizations reveals that such achievements are greatly facilitated by the effective and efficient management of the lifelong learning process. Management of lifelong learning involves facilitation of all the life-cycle events of learning specific to various contexts in life like childcare, formal education and preparation for employment, employment, entrepreneurship, and active aging. That is why almost all international organizations, like UN, WHO, World Bank, Asian Development Bank, Commonwealth of Learning (COL), universities across the world, organizations that promote entrepreneurship, government establishments, industries, skill development programmes etc promote strategies, initiatives, and platforms to nurture lifelong learning. // Sustainable Development Goal (SDG) 4 of UN sets the goal ‘Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all’. Moto of WHO Academy is ‘Transforming lifelong learning for health impact’. World Bank has a lot of reports published on the importance of lifelong learning. // In the above context, further research was conducted into the management systems and processes that facilitate efficient lifelong learning experience to help the world to develop models that can be easily adopted. It will equip the mankind with capabilities for tackling the present and future challenges of life; especially as the world anticipates tremendous escalation of foreseen and unforeseen challenges due to the cumulative effect of climate change and socio-economic factors. The graduation of learning from the individual level to organization level and broader societal level also studied. The study has been conducted based on the literature available on the internet and the learning from hundreds of capacity building sessions facilitated by the authors over a long period of time. // The study identified learning management strategies that facilitate identification of the right learning path by individuals and preparedness of individuals, organizations and societies to remain proactive and agile are vital factors in promoting lifelong learning for sustainable development.
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Chacon, Joel Ramon, and Peter Dabrowski. "Production Technology Workbench: Developing and Scaling a Corporate Digital Product Using Agile Methods." In Abu Dhabi International Petroleum Exhibition & Conference. SPE, 2021. http://dx.doi.org/10.2118/207922-ms.
Повний текст джерелаАнотація:
Objectives/Scope The production technology working environment of an oil brownfield is usually an inconsistent collection of tools and spreadsheets. In this paper, we will explore Wintershall Dea's digitalisation journey from a patchwork of tools and spreadsheets to a unified corporate Production Technology Workbench (PTW) solution starting from the replacement of an existing and ageing tool on an asset on the Norwegian continental shelf and ending by incorporating the requirements of other assets from Wintershall Dea's diverse and geographically dispersed portfolio. Methods, Procedures, Processes The project started by selecting the low-code application platform suitable to be used as the basis for the journey. After a proof-of-concept stage, an Agile project was launched owned by the asset and with a geographically dispersed Development Team conformed by Wintershall Dea's Product Owners, IT/OT experts, UX consultants and Eigen's scrum master and Development Team. After the delivery of the MVP, a second Product Owner was incorporated from a second asset. The Agile project continued to deliver on enhanced functionality and requirements that would most benefit both assets. Results, Observations, Conclusions The original production system calculations and workflows are vital for the asset. However, such patchworks are not easy to work with and complex to maintain or change. This had a negative effect on the efficiency as work is time-consuming and cumbersome. Well anomalies were often detected by actively looking for them daily in various plots, reports and platforms, and therefore the detection and response time to production events was delayed. A Production Technology dashboard with built-in / automated data processing for standard tasks provides engineers with the required transparency of data to identify issues and pain-points in a timely manner. This helps engineers to proactively intervene to mitigate unplanned losses and downtime, reducing the amount of deferred production. Investment in a corporate-wide unified (standard UX) platform, will help engineers when starting new assignments to spot issues easier and quicker independently of the asset they are assigned to. But beyond a standardization, each engineer needs to be able to create individual workflows (for effects such as scaling, slugging, sand etc.) for their needs by means of the self-service capabilities of the technology. Also, the quick access to frequently used and relevant data could be accessed through one platform, making everyday life of the production engineer more efficient and smoother. Over the timeframe of 15+ Sprints the Product Owners refined and re-defined the exact functionality they would like to see delivered. Novel/Additive Information The PTW concept seeks to minimise the time that engineers require to learn the tool and use it to inspect, analyse, and make decisions to optimise the production of the field. This is one of Wintershall Dea's first projects executed following Agile, using a geographically dispersed team, during the restrictions imposed by the pandemic. The multi-Product-Owner project approach is a novel way to govern the evolution of the tool to suit multiple stakeholders. In comparison to a E&P typical waterfall project management approach, the application of Scrum really showed added value in reducing risk early on, increasing visibility and transparency and adapting to the customer's needs (production engineers) throughout the process.
Звіти організацій з теми "Life change events Physiological effect"
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Delwiche, Michael, Boaz Zion, Robert BonDurant, Judith Rishpon, Ephraim Maltz, and Miriam Rosenberg. Biosensors for On-Line Measurement of Reproductive Hormones and Milk Proteins to Improve Dairy Herd Management. United States Department of Agriculture, February 2001. http://dx.doi.org/10.32747/2001.7573998.bard.
Повний текст джерелаАнотація:
The original objectives of this research project were to: (1) develop immunoassays, photometric sensors, and electrochemical sensors for real-time measurement of progesterone and estradiol in milk, (2) develop biosensors for measurement of caseins in milk, and (3) integrate and adapt these sensor technologies to create an automated electronic sensing system for operation in dairy parlors during milking. The overall direction of research was not changed, although the work was expanded to include other milk components such as urea and lactose. A second generation biosensor for on-line measurement of bovine progesterone was designed and tested. Anti-progesterone antibody was coated on small disks of nitrocellulose membrane, which were inserted in the reaction chamber prior to testing, and a real-time assay was developed. The biosensor was designed using micropumps and valves under computer control, and assayed fluid volumes on the order of 1 ml. An automated sampler was designed to draw a test volume of milk from the long milk tube using a 4-way pinch valve. The system could execute a measurement cycle in about 10 min. Progesterone could be measured at concentrations low enough to distinguish luteal-phase from follicular-phase cows. The potential of the sensor to detect actual ovulatory events was compared with standard methods of estrus detection, including human observation and an activity monitor. The biosensor correctly identified all ovulatory events during its testperiod, but the variability at low progesterone concentrations triggered some false positives. Direct on-line measurement and intelligent interpretation of reproductive hormone profiles offers the potential for substantial improvement in reproductive management. A simple potentiometric method for measurement of milk protein was developed and tested. The method was based on the fact that proteins bind iodine. When proteins are added to a solution of the redox couple iodine/iodide (I-I2), the concentration of free iodine is changed and, as a consequence, the potential between two electrodes immersed in the solution is changed. The method worked well with analytical casein solutions and accurately measured concentrations of analytical caseins added to fresh milk. When tested with actual milk samples, the correlation between the sensor readings and the reference lab results (of both total proteins and casein content) was inferior to that of analytical casein. A number of different technologies were explored for the analysis of milk urea, and a manometric technique was selected for the final design. In the new sensor, urea in the sample was hydrolyzed to ammonium and carbonate by the enzyme urease, and subsequent shaking of the sample with citric acid in a sealed cell allowed urea to be estimated as a change in partial pressure of carbon dioxide. The pressure change in the cell was measured with a miniature piezoresistive pressure sensor, and effects of background dissolved gases and vapor pressures were corrected for by repeating the measurement of pressure developed in the sample without the addition of urease. Results were accurate in the physiological range of milk, the assay was faster than the typical milking period, and no toxic reagents were required. A sampling device was designed and built to passively draw milk from the long milk tube in the parlor. An electrochemical sensor for lactose was developed starting with a three-cascaded-enzyme sensor, evolving into two enzymes and CO2[Fe (CN)6] as a mediator, and then into a microflow injection system using poly-osmium modified screen-printed electrodes. The sensor was designed to serve multiple milking positions, using a manifold valve, a sampling valve, and two pumps. Disposable screen-printed electrodes with enzymatic membranes were used. The sensor was optimized for electrode coating components, flow rate, pH, and sample size, and the results correlated well (r2= 0.967) with known lactose concentrations.
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Yahav, Shlomo, John Brake, and Noam Meiri. Development of Strategic Pre-Natal Cycling Thermal Treatments to Improve Livability and Productivity of Heavy Broilers. United States Department of Agriculture, December 2013. http://dx.doi.org/10.32747/2013.7593395.bard.
Повний текст джерелаАнотація:
The necessity to improve broiler thermotolerance and live performance led to the following hypothesis: Appropriate comprehensive incubation treatments that include significant temperature management changes will promote angiogenesis and will improve acquisition of thermotolerance and carcass quality of heavy broilers through epigenetic adaptation. It was based on the following questions: 1. Can TM during embryogenesis of broilers induce a longer-lasting thermoregulatory memory (up to marketing age of 10 wk) that will improve acquisition of thermotolerance as well as increased breast meat yield in heavy broilers? 2. The improved sensible heat loss (SHL) suggests an improved peripheral vasodilation process. Does elevated temperature during incubation affect vasculogenesis and angiogenesis processes in the chick embryo? Will such create subsequent advantages for heavy broilers coping with adverse hot conditions? 3. What are the changes that occur in the PO/AH that induce the changes in the threshold response for heat production/heat loss based on the concept of epigenetic temperature adaptation? The original objectives of this study were as follow: a. to assess the improvement of thermotolerance efficiency and carcass quality of heavy broilers (~4 kg); b. toimproveperipheral vascularization and angiogenesis that improve sensible heat loss (SHL); c. to study the changes in the PO/AH thermoregulatory response for heat production/losscaused by modulating incubation temperature. To reach the goals: a. the effect of TM on performance and thermotolerance of broilers reared to 10 wk of age was studied. b. the effect of preincubation heating with an elevated temperature during the 1ˢᵗ 3 to 5 d of incubation in the presence of modified fresh air flow coupled with changes in turning frequency was elucidated; c.the effect of elevated temperature on vasculogenesis and angiogenesis was determined using in ovo and whole embryo chick culture as well as HIF-1α VEGF-α2 VEGF-R, FGF-2, and Gelatinase A (MMP2) gene expression. The effects on peripheral blood system of post-hatch chicks was determined with an infrared thermal imaging technique; c. the expression of BDNF was determined during the development of the thermal control set-point in the preoptic anterior hypothalamus (PO/AH). Background to the topic: Rapid growth rate has presented broiler chickens with seriousdifficulties when called upon to efficiently thermoregulate in hot environmental conditions. Being homeotherms, birds are able to maintain their body temperature (Tb) within a narrow range. An increase in Tb above the regulated range, as a result of exposure to environmental conditions and/or excessive metabolic heat production that often characterize broiler chickens, may lead to a potentially lethal cascade of irreversible thermoregulatory events. Exposure to temperature fluctuations during the perinatal period has been shown to lead to epigenetic temperature adaptation. The mechanism for this adaptation was based on the assumption that environmental factors, especially ambient temperature, have a strong influence on the determination of the “set-point” for physiological control systems during “critical developmental phases.” Recently, Piestunet al. (2008) demonstrated for the first time that TM (an elevated incubation temperature of 39.5°C for 12 h/d from E7 to E16) during the development/maturation of the hypothalamic-hypophyseal-thyroid axis (thermoregulation) and the hypothalamic-hypophyseal-adrenal axis (stress) significantly improved the thermotolerance and performance of broilers at 35 d of age. These phenomena raised two questions that were addressed in this project: 1. was it possible to detect changes leading to the determination of the “set point”; 2. Did TM have a similar long lasting effect (up to 70 d of age)? 3. Did other TM combinations (pre-heating and heating during the 1ˢᵗ 3 to 5 d of incubation) coupled with changes in turning frequency have any performance effect? The improved thermotolerance resulted mainly from an efficient capacity to reduce heat production and the level of stress that coincided with an increase in SHL (Piestunet al., 2008; 2009). The increase in SHL (Piestunet al., 2009) suggested an additional positive effect of TM on vasculogenesis and angiogensis. 4. In order to sustain or even improve broiler performance, TM during the period of the chorioallantoic membrane development was thought to increase vasculogenesis and angiogenesis providing better vasodilatation and by that SHL post-hatch.
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Hochman, Ayala, Thomas Nash III, and Pamela Padgett. Physiological and Biochemical Characterization of the Effects of Oxidant Air Pollutants, Ozone and Gas-phase Nitric Acid, on Plants and Lichens for their Use as Early Warning Biomonitors of these Air Pollutants. United States Department of Agriculture, January 2011. http://dx.doi.org/10.32747/2011.7697115.bard.
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Introduction. Ozone and related oxidants are regarded as the most important phytotoxic air pollutant in many parts of the western world. A previously unrecognized component of smog, nitric acid, may have even greater deleterious effects on plants either by itself or by augmenting ozone injury. The effects of ozone on plants are well characterized with respect to structural and physiological changes, but very little is known about the biochemical changes in plants and lichens exposed to ozone and/or HNO3. Objectives.To compare and contrast the responses of crop plants and lichens to dry deposition of HNO3 and O3., separately, and combined in order to assess our working hypothesis that lichens respond to air pollution faster than plants. Lichens are most suitable for use as biomonitors because they offer a live-organism-based system that does not require maintenance and can be attached to any site, without the need for man-made technical support systems. Original Immediate aims To expose the tobacco (Nicotiana tabacum L.) cultivar Bel-W3 that is ozone supersensitive and the ozone sensitive red kidney bean (Phaseolusvulgaris) and the lichen Ramalinamenziesii to controlled HNO3 and O3 fumigations and combined and to follow the resulting structural, physiological and biochemical changes, with special reference to reactive oxygen species related parameters. Revised. Due to technical problems and time limitations we studied the lichen Ramalinamenziesii and two cultivar of tobacco: Bel-W3 that is ozone supersensitive and a resistant cultivar, which were exposed to HNO3 and O3 alone (not combined). Methodology. Plants and lichens were exposed in fumigation experiments to HNO3 and O3, in constantly stirred tank reactors and the resulting structural, physiological and biochemical changes were analyzed. Results. Lichens. Exposure of Ramalinamenziesiito HNO3 resulted in cell membrane damage that was evident by 14 days and continues to worsen by 28 days. Chlorophyll, photosynthesis and respiration all declined significantly in HNO3 treatments, with the toxic effects increasing with dosage. In contrast, O3 fumigations of R. menziesii showed no significant negative effects with no differences in the above response variables between high, moderate and low levels of fumigations. There was a gradual decrease in catalase activity with increased levels of HNO3. The activity of glutathione reductase dropped to 20% in thalli exposed to low HNO3 but increased with its increase. Glucose 6-phosphate dehydrogenase activity increase by 20% with low levels of the pollutants but decreased with its increase. Tobacco. After 3 weeks of exposure of the sensitive tobacco cultivar to ozone there were visible symptoms of toxicity, but no danmage was evident in the tolerant cultivar. Neither cultivar showed any visible symptoms after exposure to HNO3.In tobacco fumigated with O3, there was a significant decrease in maximum photosynthetic CO2 assimilation and stomatal conductance at high levels of the pollutant, while changes in mesophyll conductance were not significant. However, under HNO3 fumigation there was a significant increase in mesophyll conductance at low and high HNO3 levels while changes in maximum photosynthetic CO2 assimilation and stomatal conductance were not significant. We could not detect any activity of the antioxidant enzymes in the fumigated tobacco leaves. This is in spite of the fact that we were able to assay the enzymes in tobacco leaves grown in Israel. Conclusions. This project generated novel data, and potentially applicable to agriculture, on the differential response of lichens and tobacco to HNO3 and O3 pollutants. However, due to experimental problems and time limitation discussed in the body of the report, our data do not justify yet application for a full, 4-year grant. We hope that in the future we shall conduct more experiments related to our objectives, which will serve as a basis for a larger scale project to explore the possibility of using lichens and/or plants for biomonitoring of ozone and nitric acid air pollution.
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Meiri, Noam, Michael D. Denbow, and Cynthia J. Denbow. Epigenetic Adaptation: The Regulatory Mechanisms of Hypothalamic Plasticity that Determine Stress-Response Set Point. United States Department of Agriculture, November 2013. http://dx.doi.org/10.32747/2013.7593396.bard.
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Our hypothesis was that postnatal stress exposure or sensory input alters brain activity, which induces acetylation and/or methylation on lysine residues of histone 3 and alters methylation levels in the promoter regions of stress-related genes, ultimately resulting in long-lasting changes in the stress-response set point. Therefore, the objectives of the proposal were: 1. To identify the levels of total histone 3 acetylation and different levels of methylation on lysine 9 and/or 14 during both heat and feed stress and challenge. 2. To evaluate the methylation and acetylation levels of histone 3 lysine 9 and/or 14 at the Bdnfpromoter during both heat and feed stress and challenge. 3. To evaluate the levels of the relevant methyltransferases and transmethylases during infliction of stress. 4. To identify the specific localization of the cells which respond to both specific histone modification and the enzyme involved by applying each of the stressors in the hypothalamus. 5. To evaluate the physiological effects of antisense knockdown of Ezh2 on the stress responses. 6. To measure the level of CpG methylation in the promoter region of BDNF in thermal treatments and free-fed, 12-hour fasted, and re-fed chicks during post-natal day 3, which is the critical period for feed-control establishment, and 10 days later to evaluate longterm effects. 7. The phenotypic effect of antisense “knock down” of the transmethylaseDNMT 3a. Background: The growing demand for improvements in poultry production requires an understanding of the mechanisms governing stress responses. Two of the major stressors affecting animal welfare and hence, the poultry industry in both the U.S. and Israel, are feed intake and thermal responses. Recently, it has been shown that the regulation of energy intake and expenditure, including feed intake and thermal regulation, resides in the hypothalamus and develops during a critical post-hatch period. However, little is known about the regulatory steps involved. The hypothesis to be tested in this proposal is that epigenetic changes in the hypothalamus during post-hatch early development determine the stress-response set point for both feed and thermal stressors. The ambitious goals that were set for this proposal were met. It was established that both stressors i.e. feed and thermal stress, can be manipulated during the critical period of development at day 3 to induce resilience to stress later in life. Specifically it was established that unfavorable nutritional conditions during early developmental periods or heat exposure influences subsequent adaptability to those same stressful conditions. Furthermore it was demonstrated that epigenetic marks on the promoter of genes involved in stress memory are altered both during stress, and as a result, later in life. Specifically it was demonstrated that fasting and heat had an effect on methylation and acetylation of histone 3 at various lysine residues in the hypothalamus during exposure to stress on day 3 and during stress challenge on day 10. Furthermore, the enzymes that perform these modifications are altered both during stress conditioning and challenge. Finally, these modifications are both necessary and sufficient, since antisense "knockdown" of these enzymes affects histone modifications, and as a consequence stress resilience. DNA methylation was also demonstrated at the promoters of genes involved in heat stress regulation and long-term resilience. It should be noted that the only goal that we did not meet because of technical reasons was No. 7. In conclusion: The outcome of this research may provide information for the improvement of stress responses in high yield poultry breeds using epigenetic adaptation approaches during critical periods in the course of early development in order to improve animal welfare even under suboptimum environmental conditions.
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Meidan, Rina, and Joy Pate. Roles of Endothelin 1 and Tumor Necrosis Factor-A in Determining Responsiveness of the Bovine Corpus Luteum to Prostaglandin F2a. United States Department of Agriculture, January 2004. http://dx.doi.org/10.32747/2004.7695854.bard.
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The corpus luteum (CL) is a transient endocrine gland that has a vital role in the regulation of the estrous cycle, fertility and the maintenance of pregnancy. In the absence of appropriate support, such as occurs during maternal recognition of pregnancy, the CL will regress. Prostaglandin F2a (PGF) was first suggested as the physiological luteolysin in ruminants several decades ago. Yet, the cellular mechanisms by which PGF causes luteal regression remain poorly defined. In recent years it became evident that the process of luteal regression requires a close cooperation between steroidogenic, endothelial and immune cells, all resident cells of this gland. Changes in the population of these cells within the CL closely consort with the functional changes occurring during various stages of CL life span. The proposal aimed to gain a better understanding of the intra-ovarian regulation of luteolysis and focuses especially on the possible reasons causing the early CL (before day 5) to be refractory to the luteolytic actions of PGF. The specific aims of this proposal were to: determine if the refractoriness of the early CL to PGF is due to its inability to synthesize or respond to endothelin–1 (ET-1), determine the cellular localization of ET, PGF and tumor necrosis factor a (TNF a) receptors in early and mid luteal phases, determine the functional relationships among ET-1 and cytokines, and characterize the effects of PGF and ET-1 on prostaglandin production by luteal cell types. We found that in contrast to the mature CL, administration of PGF2a before day 5 of the bovine cycle failed to elevate ET-1, ETA receptors or to induce luteolysis. In fact, PGF₂ₐ prevented the upregulation of the ET-1 gene by ET-1 or TNFa in cultured luteal cells from day 4 CL. In addition, we reported that ECE-1 expression was elevated during the transitionof the CL from early to mid luteal phase and was accompanied by a significant rise in ET-1 peptide. This coincides with the time point at which the CL gains its responsiveness to PGF2a, suggesting that ability to synthesize ET-1 may be a prerequisite for luteolysis. We have shown that while ET-1 mRNA was exclusively localized to endothelial cells both in young and mature CL, ECE-1 was present in the endothelial cells and steroidogenic cells alike. We also found that the gene for TNF receptor I is only moderately affected by the cytokines tested, but that the gene for TNF receptor II is upregulated by ET-1 and PGF₂ₐ. However, these cytokines both increase expression of MCP-1, although TNFa is even more effective in this regard. In addition, we found that proteins involved in the transport and metabolism of PGF (PGT, PGDH, COX-2) change as the estrous cycle progresses, and could contribute to the refractoriness of young CL. The data obtained in this work illustrate ET-1 synthesis throughout the bovine cycle and provide a better understanding of the mechanisms regulating luteal regression and unravel reasons causing the CL to be refractory to PGF2a.