Готові списки джерел за темами / Kv3

Добірка наукової літератури з теми "Kv3"

Автор: Grafiati
Опубліковано: 10 грудня 2022
Оновлено: 28 січня 2023

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Статті в журналах з теми "Kv3"

1

Bocksteins, Elke, Gerda Van de Vijver, Pierre-Paul Van Bogaert, and Dirk J. Snyders. "Kv3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons." American Journal of Physiology-Cell Physiology 303, no. 4 (August 15, 2012): C406—C415. http://dx.doi.org/10.1152/ajpcell.00343.2011.

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Анотація:
Delayed rectifier voltage-gated K+ (KV) channels are important determinants of neuronal excitability. However, the large number of KV subunits poses a major challenge to establish the molecular composition of the native neuronal K+ currents. A large part (∼60%) of the delayed rectifier current ( IK) in small mouse dorsal root ganglion (DRG) neurons has been shown to be carried by both homotetrameric KV2.1 and heterotetrameric channels of KV2 subunits with silent KV subunits (KVS), while a contribution of KV1 channels has also been demonstrated. Because KV3 subunits also generate delayed rectifier currents, we investigated the contribution of KV3 subunits to IK in small mouse DRG neurons. After stromatoxin (ScTx) pretreatment to block the KV2-containing component, application of 1 mM TEA caused significant additional block, indicating that the ScTx-insensitive part of IK could include KV1, KV3, and/or M-current channels (KCNQ2/3). Combining ScTx and dendrotoxin confirmed a relevant contribution of KV2 and KV2/KVS, and KV1 subunits to IK in small mouse DRG neurons. After application of these toxins, a significant TEA-sensitive current (∼19% of total IK) remained with biophysical properties that corresponded to those of KV3 currents obtained in expression systems. Using RT-PCR, we detected KV3.1–3 mRNA in DRG neurons. Furthermore, Western blot and immunocytochemistry using KV3.1-specific antibodies confirmed the presence of KV3.1 in cultured DRG neurons. These biophysical, pharmacological, and molecular results demonstrate a relevant contribution (∼19%) of KV3-containing channels to IK in small mouse DRG neurons, supporting a substantial role for KV3 subunits in these neurons.
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2

ZHU, Jing, Barbara GOMEZ, Itaru WATANABE, and William B. THORNHILL. "Amino acids in the pore region of Kv1 potassium channels dictate cell-surface protein levels: a possible trafficking code in the Kv1 subfamily." Biochemical Journal 388, no. 1 (May 10, 2005): 355–62. http://dx.doi.org/10.1042/bj20041447.

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Анотація:
Kv1.1 and Kv1.4 potassium channels have different pore region determinants that were found to affect their cell-surface levels positively and negatively [Zhu, Watanabe, Gomez and Thornhill (2001) J. Biol. Chem. 276, 39419–39427; Zhu, Watanabe, Gomez and Thornhill (2003) J. Biol. Chem. 278, 25558–25567; Zhu, Watanabe, Gomez and Thornhill (2003) Biochem. J. 375, 761–768]. In the present study, we focused on the deep pore region of Kv1 members to test whether a cell-surface trafficking code was dictated by two amino acids. Kv1 channels with a threonine/lysine amino acid pair in a non-contiguous pore region promoted high surface levels, whereas a serine/tyrosine amino acid pair inhibited high surface expression by inducing a high level of partial endoplasmic reticulum retention. Our work suggests that a possible positive trafficking amino acid pair coding here for the Kv1 subfamily is Thr/Lys>Thr/Val>Thr/Tyr>Thr/Arg∼Thr/His>Ser/Val>Ser/Tyr>Ser/Lys. The Kv1 trafficking code was not transferable to a Kv2 family member and thus it appears that it only governs surface levels in the context of its Kv1 native pore loop region and/or its S5 and S6 regions. All members of a given Kv2, Kv3 or Kv4 potassium channel subfamily have identical amino acids at similar positions in their deep pore regions (Thr/Tyr or Thr/Val), which suggests that any difference in surface levels among members is not dictated by these amino acids. Thus a major determinant for cell-surface trafficking of Kv1 potassium channels is an amino acid pair in their deep pore regions, whereas the cell-surface levels of a given Kv2, Kv3 or Kv4 subfamily member are probably not affected by these amino acids.
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3

B, Pooja, Govinda Sharma K, and Vinay R. Kadibagil. "Pharmaceutical Modification of Kasisadi Churna to Varti and its Physicochemical Analysis." International Journal of Ayurvedic Medicine 11, no. 3 (October 2, 2020): 470–76. http://dx.doi.org/10.47552/ijam.v11i3.1589.

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Анотація:
Background: Kasisadi churna is a yoga (formulation) mentioned for treatment of kaphaja yoni vyapath (vulvo vaginal candidiasis) which is applied as lepa along with honey. But the administration of the drug through vaginal route in this form is highly discomforting. Modification of a dosage form is essential for the enhancement of efficacy, acceptability of the product and shelf life. Materials and Methods: Varti is prepared from the drugs of kasisadi churna in three methods, bhavana method (KV1), gudapaka method (KV2) and modified method (KV3) with the addition of cocoa butter as base. The prepared samples were tested for analytical parameters. Result and Discussion: Kasisadi churna can be easily modified into varti form. Preparation of KV2 was easy, gives more yield in less time and better in organoleptic features and disintegration time compared to KV1 and KV3. Conclusion: The results of the pharmaceutical and analytical study can be considered as the preliminary standards for the preparation of Kasisadi Varti.
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4

Bocksteins, Elke. "Kv5, Kv6, Kv8, and Kv9 subunits: No simple silent bystanders." Journal of General Physiology 147, no. 2 (January 11, 2016): 105–25. http://dx.doi.org/10.1085/jgp.201511507.

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Анотація:
Members of the electrically silent voltage-gated K+ (Kv) subfamilies (Kv5, Kv6, Kv8, and Kv9, collectively identified as electrically silent voltage-gated K+ channel [KvS] subunits) do not form functional homotetrameric channels but assemble with Kv2 subunits into heterotetrameric Kv2/KvS channels with unique biophysical properties. Unlike the ubiquitously expressed Kv2 subunits, KvS subunits show a more restricted expression. This raises the possibility that Kv2/KvS heterotetramers have tissue-specific functions, making them potential targets for the development of novel therapeutic strategies. Here, I provide an overview of the expression of KvS subunits in different tissues and discuss their proposed role in various physiological and pathophysiological processes. This overview demonstrates the importance of KvS subunits and Kv2/KvS heterotetramers in vivo and the importance of considering KvS subunits and Kv2/KvS heterotetramers in the development of novel treatments.
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5

Kaczmarek, Leonard K., and Yalan Zhang. "Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal Endurance." Physiological Reviews 97, no. 4 (October 1, 2017): 1431–68. http://dx.doi.org/10.1152/physrev.00002.2017.

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Анотація:
The intrinsic electrical characteristics of different types of neurons are shaped by the K+ channels they express. From among the more than 70 different K+ channel genes expressed in neurons, Kv3 family voltage-dependent K+ channels are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. In general, the four Kv3 channels Kv3.1–Kv3.4 share the property of activating and deactivating rapidly at potentials more positive than other channels. Each Kv3 channel gene can generate multiple protein isoforms, which contribute to the high-frequency firing of neurons such as auditory brain stem neurons, fast-spiking GABAergic interneurons, and Purkinje cells of the cerebellum, and to regulation of neurotransmitter release at the terminals of many neurons. The different Kv3 channels have unique expression patterns and biophysical properties and are regulated in different ways by protein kinases. In this review, we cover the function, localization, and modulation of Kv3 channels and describe how levels and properties of the channels are altered by changes in ongoing neuronal activity. We also cover how the protein-protein interaction of these channels with other proteins affects neuronal functions, and how mutations or abnormal regulation of Kv3 channels are associated with neurological disorders such as ataxias, epilepsies, schizophrenia, and Alzheimer’s disease.
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6

Friederich, Patrick, Dietmar Benzenberg, Sokratis Trellakis, and Bernd W. Urban. "Interaction of Volatile Anesthetics with Human Kv Channels in Relation to Clinical Concentrations." Anesthesiology 95, no. 4 (October 1, 2001): 954–58. http://dx.doi.org/10.1097/00000542-200110000-00026.

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Background Recent evidence shows that inhibition of human Kv3 channels by intravenous anesthetics occurs at clinical concentrations. The effects of volatile anesthetics on these human ion channels are unknown. This study was designed to establish whether minimum alveolar concentrations (MAC) of halothane, enflurane, isoflurane, and desflurane exhibit effects on Kv3 channeLs. To obtain an indication whether these findings may be specific to Kv3 channels, the effects of enflurane and isoflurane on human Kv1.1 channels were also investigated. Methods Kv3 channels natively expressed in SH-SY5Y cells and Kv1.1 channels expressed in HEK293 cells were measured with the whole cell patch clamp technique by standard protocols. Concentrations of volatile anesthetics were determined by gas chromatography. Results Halothane, enflurane, isoflurane, and desflurane reversibly inhibited Kv3 channels in a concentration-dependent manner. Concentrations at half-maximal effect (IC50 values) ranged between 1,800 and 4,600 microM. Hill coefficients were between 1.7 and 2.5. IC50 values for inhibition of Kv1.1 channels were 2,800 and 5,200 microM, and Hill coefficients were 3.9 and 5.6 for enflurane and isoflurane, respectively. Conclusion Volatile anesthetics inhibit human Kv3 channels at clinical concentrations. At 1-3 MAC, inhibition would account on average for 2-12%. Inhibition would be highest with enflurane (between 3% and 22%) and lowest with isoflurane (between 0.2% and 3%). Kv1.1 channels would only be inhibited by enflurane at clinical concentrations (2% at 2 MAC and 8% at 3 MAC). Whether the degree of K channel inhibition by volatile anesthetics may contribute to their clinical action needs further study.
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7

Klassen, Tara L., Steven D. Buckingham, Donna M. Atherton, Joel B. Dacks, Warren J. Gallin, and Andrew N. Spencer. "Atypical Phenotypes From Flatworm Kv3 Channels." Journal of Neurophysiology 95, no. 5 (May 2006): 3035–46. http://dx.doi.org/10.1152/jn.00858.2005.

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Анотація:
Divergence of the Shaker superfamily of voltage-gated (Kv) ion channels early in metazoan evolution created numerous electrical phenotypes that were presumably selected to produce a wide range of excitability characteristics in neurons, myocytes, and other cells. A comparative approach that emphasizes this early radiation provides a comprehensive sampling of sequence space that is necessary to develop generally applicable models of the structure–function relationship in the Kv potassium channel family. We have cloned and characterized two Shaw-type potassium channels from a flatworm ( Notoplana atomata) that is arguably a representative of early diverging bilaterians. When expressed in Xenopus oocytes, one of these cloned channels, N.at-Kv3.1, exhibits a noninactivating, outward current with slow opening kinetics that are dependent on both the holding potential and the activating potential. A second Shaw-type channel, N.at-Kv3.2, has very different properties, showing weak inward rectification. These results demonstrate that broad phylogenetic sampling of proteins of a single family will reveal unexpected properties that lead to new interpretations of structure–function relationships.
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8

Pilati, Nadia, Michele Speggiorin, Giuseppe Alvaro, and Charles H. Large. "Pharmacological Modulation of Kv3 Potassium Currents." Biophysical Journal 116, no. 3 (February 2019): 540a. http://dx.doi.org/10.1016/j.bpj.2018.11.2905.

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9

Pisupati, Aditya, Keith J. Mickolajczyk, William Horton, Damian B. van Rossum, Andriy Anishkin, Sree V. Chintapalli, Xiaofan Li, et al. "The S6 gate in regulatory Kv6 subunits restricts heteromeric K+ channel stoichiometry." Journal of General Physiology 150, no. 12 (October 15, 2018): 1702–21. http://dx.doi.org/10.1085/jgp.201812121.

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Анотація:
The Shaker-like family of voltage-gated K+ channels comprises four functionally independent gene subfamilies, Shaker (Kv1), Shab (Kv2), Shaw (Kv3), and Shal (Kv4), each of which regulates distinct aspects of neuronal excitability. Subfamily-specific assembly of tetrameric channels is mediated by the N-terminal T1 domain and segregates Kv1–4, allowing multiple channel types to function independently in the same cell. Typical Shaker-like Kv subunits can form functional channels as homotetramers, but a group of mammalian Kv2-related genes (Kv5.1, Kv6s, Kv8s, and Kv9s) encodes subunits that have a “silent” or “regulatory” phenotype characterized by T1 self-incompatibility. These channels are unable to form homotetramers, but instead heteromerize with Kv2.1 or Kv2.2 to diversify the functional properties of these delayed rectifiers. While T1 self-incompatibility predicts that these heterotetramers could contain up to two regulatory (R) subunits, experiments show a predominance of 3:1R stoichiometry in which heteromeric channels contain a single regulatory subunit. Substitution of the self-compatible Kv2.1 T1 domain into the regulatory subunit Kv6.4 does not alter the stoichiometry of Kv2.1:Kv6.4 heteromers. Here, to identify other channel structures that might be responsible for favoring the 3:1R stoichiometry, we compare the sequences of mammalian regulatory subunits to independently evolved regulatory subunits from cnidarians. The most widespread feature of regulatory subunits is the presence of atypical substitutions in the highly conserved consensus sequence of the intracellular S6 activation gate of the pore. We show that two amino acid substitutions in the S6 gate of the regulatory subunit Kv6.4 restrict the functional stoichiometry of Kv2.1:Kv6.4 to 3:1R by limiting the formation and function of 2:2R heteromers. We propose a two-step model for the evolution of the asymmetric 3:1R stoichiometry, which begins with evolution of self-incompatibility to establish the regulatory phenotype, followed by drift of the activation gate consensus sequence under relaxed selection to limit stoichiometry to 3:1R.
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10

Ozaita, A., M. E. Martone, M. H. Ellisman, and B. Rudy. "Differential Subcellular Localization of the Two Alternatively Spliced Isoforms of the Kv3.1 Potassium Channel Subunit in Brain." Journal of Neurophysiology 88, no. 1 (July 1, 2002): 394–408. http://dx.doi.org/10.1152/jn.2002.88.1.394.

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Анотація:
Voltage-gated K+ channels containing pore-forming subunits of the Kv3 subfamily have specific roles in the fast repolarization of action potentials and enable neurons to fire repetitively at high frequencies. Each of the four known Kv3 genes encode multiple products by alternative splicing of 3′ ends resulting in the expression of K+ channel subunits differing only in their C-terminal sequence. The alternative splicing does not affect the electrophysiological properties of the channels, and its physiological role is unknown. It has been proposed that one of the functions of the alternative splicing of Kv3 genes is to produce subunit isoforms with differential subcellular membrane localizations in neurons and differential modulation by signaling pathways. We investigated the role of the alternative splicing of Kv3 subunits in subcellular localization by examining the brain distribution of the two alternatively spliced versions of the Kv3.1 gene (Kv3.1a and Kv3.1b) with antibodies specific for the alternative spliced C-termini. Kv3.1b proteins were prominently expressed in the somatic and proximal dendritic membrane of specific neuronal populations in the mouse brain. The axons of most of these neurons also expressed Kv3.1b protein. In contrast, Kv3.1a proteins were prominently expressed in the axons of some of the same neuronal populations, but there was little to no Kv3.1a protein expression in somatodendritic membrane. Exceptions to this pattern were seen in two neuronal populations with unusual targeting of axonal proteins, mitral cells of the olfactory bulb, and mesencephalic trigeminal neurons, which expressed Kv3.1a protein in dendritic and somatic membrane, respectively. The results support the hypothesis that the alternative spliced C-termini of Kv3 subunits regulate their subcellular targeting in neurons.
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Більше джерел

Дисертації з теми "Kv3"

1

Yeung, Shuk Yin. "Pharmacological study of fluoxetine and BDS toxins on central Kv1 and Kv3 channel subfamily members." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415328.

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2

Rashid, Asim J. "Contribution of Kv3 potassium channels to signal processing by electrosensory neurons." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38513.

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Анотація:
Gamma-frequency burst discharge in pyramidal cells of the apteronotid electrosensory lateral line lobe (ELL) is necessary for signal processing. Bursting is dependent on an interaction between somatic and apical dendritic currents, in which spike broadening in the apical dendrite potentiates a somatic afterpotential that follows each rapid somatic spike. Somatic spike repolarization must be consistent in order for the afterpotential to be expressed soon after. The work presented in this thesis describes how the expression and differential subcellular distribution of two Kv3-type K+ channels in ELL pyramidal cells may contribute to this mechanism of burst discharge.
I cloned a family of Kv3 channels from an apteronotid brain cDNA library and demonstrated that two of these channels, homologues of the mammalian subtypes Kv3.1 and Kv3.3, are expressed in ELL pyramidal cells. Immunohistochemical analysis demonstrated that the AptKv3.3 K+ channel is distributed throughout the dendrites of pyramidal cells while the AptKv3.1 channel is restricted in its expression to pyramidal cell somata, basilar dendrites and proximal apical dendrites. Heterologous expression of each channel in HEK 293 cells indicated that AptKv3.3 encodes a high-threshold inactivating K + current while AptKv3.1 encodes a high-threshold K+ current which does not display inactivation upon prolonged membrane depolarization. Based on these results as well as pharmacological analysis of native ELL pyramidal cells, I propose that AptKv3.3 mediates spike repolarization in the apical dendrite and inactivation of the channel during repetitive firing allows spike broadening. In contrast, AptKv3.1 likely contributes towards rapid and consistent spike repolarization in the cell soma. Therefore, the expression and differential distribution of these two Kv3 channels in ELL pyramidal cells may underlie the compartmental differences in spike repolarzation that is necessary for burst discharge.
The extensive dendritic localization of AptKv3.3 observed in ELL pyramidal cells as well as in other hindbrain neurons has not previously been demonstrated for members of the Kv3 family of K+ channels. The differential localization of AptKv3.1. AptKv3.3 and possibly AptKv3.3 splice variants that I have identified presents an opportunity to examine the molecular mechanisms of Kv3 channel targeting in neurons. Preliminary data is presented which provides the foundation for future studies on channel targeting.
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3

Illy, Marcus [Verfasser], and Peter [Akademischer Betreuer] Jonas. "Functional role of presynaptic Kv3 channels on synaptic transmission at the basket cell-granule cell synapse = Die funktionelle Aufgabe von präsynaptischen Kv3 Kanälen bei der synaptischen Transmission an der Korbzell-Körnerzell Synapse." Freiburg : Universität, 2012. http://d-nb.info/1123470928/34.

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4

Baier, Julia [Verfasser], Tobias [Akademischer Betreuer] Huth, and Christian [Gutachter] Alzheimer. "Untersuchung der Oberflächenexpression von Kv3-Kanalkomplexen im Zusammenhang mit der beta-Sekretase BACE1. / Julia Baier ; Gutachter: Christian Alzheimer ; Betreuer: Tobias Huth." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2021. http://d-nb.info/1238358446/34.

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5

El, Haou Saïd. "Régulation des canaux potassiques cardiaques par la protéine d'accrochage SAP97." Paris 6, 2009. http://www.theses.fr/2009PA066258.

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Анотація:
Les canaux ioniques sont des protéines enchâssées dans la membrane cellulaire responsables de l’activité électrique, notamment au niveau cardiaque. Ces canaux sont constitués du pore canalaire mais également de nombreuses protéines partenaires. Parmi ces protéines partenaires les protéines MAGUK (Membrane Associated Guanlytate Kinase) apparaissent comme étant des éléments essentiels au bon fonctionnement des canaux ioniques cardiaques. Dans cette étude, nous avons examiné le rôle de la protéine MAGUK appelée SAP97 (Synapse Associated Protein) sur divers canaux potassiques cardiaques responsables de la repolarisation du myocarde. Nos résultats ont montré que la SAP97 régule l’expression membranaire de ces canaux dans les myocytes cardiaques. De plus, nous avons montré que la SAP97 participe à la formation d’un complexe tripartite entre les canaux Kv4 et la CaMKII. L’ensemble de ces travaux a permis de montrer les protéines MAGUK joueraient un rôle majeur dans l’organisation de complexes permettant l’organisation et le couplage de l’activité électrique avec la signalisation intracellulaire.
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6

Sparrenbom, Charlotte Jönsson. "Constraining the southern part of the Greenland Ice Sheet since the Last Glacial Maximum from relative sea-level changes, cosmogenic dates and glacial-isostatic adjustment models." Lund : Department of Geology, GeoBiosphere Science Centre, Lund University, 2006. http://www.geol.lu.se/kvg/avhandlingar/cs_kappa.pdf.

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7

Tur, Jared. "Cardiovascular regulation by Kvβ1.1 subunit". Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6596.

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Анотація:
Heterologous expression systems such as COS-7 cells have demonstrated the profound effects of KCNAB1-3 or Kvβ1-3 proteins on voltage gated potassium channels (Kv) channels. Indeed, in the presence of these β-subunits transiently expressed Kv channels are often modulated in multiple ways. Kv channel membrane expression is often increased in the presence of β-subunits. In addition, non-inactivating Kv currents suddenly become fast-inactivating and fast-inactivating channels become even faster. While much research has demonstrated the profound effects the β-subunits in particular the Kvβ1 subunit have on transiently expressed Kv currents little to date is known of the physiological role it may play. One study demonstrated that by “knocking out” Kvβ1 cardiomyocyte current changes were noted including a decrease in the Ito,f current. While this novel finding demonstrated a key cardiac physiological role of the Kvβ1 subunit it left many unanswered questions as to determine the cardiovascular regulation the Kvβ1 subunit provides. Indeed, cardiac arrhythmias and other electrical abnormalities within the heart such as long QT present patients with many unfortunate unknowns. Many of these incidences occur often abruptly with cardiac electrical abnormalities. Genetic research has begun to shine light on key cardiovascular genes in particular those coding for ion channels and auxiliary subunits or β-subunits. Kv channels and their β-subunits have gained particular notoriety in their key responsibility in restoring the resting membrane potential known as the repolarization phase. Indeed genetic manipulation and physiological examination of Kv channels and recently their β-subunits has demonstrated profound physiological results including prolonged QT durations within mice altered functional activity during physiological cycles such as estrus. While initial findings of Kvβ1 have demonstrated profound cellular and cardiomyocyte current alterations much still remains unknown. Therefore, this work hypothesizes that the Kvβ1 subunit provides a profound cardiovascular role in regulation and redox sensing at the physiological and pathophysiological level in both males and females. This work identifies a sex-based difference in cardiovascular regulation by Kvβ1 as well as demonstrated a profound redox sensing ability during altered metabolic states seen in pathophysiological conditions.
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8

Andersson, Carl Fredrik. "50 kVA eller 100 kVA : En teknisk och ekonomisk jämförelse av distributionstransformatorer." Thesis, Högskolan Väst, Institutionen för ingenjörsvetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-2730.

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Анотація:
Rapporten utreder om distributionstransformatorer med märkeffekten 50 kVA i Vattenfall Eldistribution AB:s elnät kan avskaffas till förmån för märkeffekten 100 kVA. Transformatorer med märkeffekten 50 kVA förekommer vid nedtransformering av spänningen från 22 kV och 11 kV till hushållens huvudspänning 0,4 kV. 50 kVA-transformatorer skiljer inte särskilt mycket från transformatorer med den högre märkeffekten i fråga om storlek och pris, och de bedöms kunna bytas ut utan större praktiska svårigheter. Fördelen med 100 kVA är att de elektriska belastningsförlusterna blir lägre i och med den högre märkeffekten. Dessutom innebär ett byte vissa elkvalitetsförbättringar. Nackdelarna med 100 kVA är att de elektriska tomgångsförlusterna är högre och att inköpspriset är högre än för 50 kVA. I övrigt kan kostnaderna likställas för de två alternativen. Endast kostnader för aktiva effektförluster berördes i rapporten då de ekonomiska kostnaderna för reaktiva effektförluster kunde försummas för de aktuella transformatorerna. För att nå ett svar på frågan om det kan vara lönsamt att avskaffa 50 kVA-transformatorerna studerades fem verkliga fall i Vattenfalls svenska elnät. Dessutom studerades eventuella elkvalitetsvinster med ett byte. Svaret blev att inte för något av de fem studerade fallen var det lönsamt med ett byte till 100 kVA-transformator. Rörande elkvalitetsaspekten blev svaret att ett byte visserligen innebär en skillnad men att andra faktorer oftast har större betydelse. Rapportens rekommendation blev att behålla 50 kVA-transformatorn i distributionsnätet.
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9

Rauber, Daniel Walter. "Die Freizügigkeit nach KVG /." [S.l.] : [s.n.], 1985. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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10

Pavlou, Petro. "KVA in Black Scholes Pricing." Master's thesis, Faculty of Commerce, 2019. http://hdl.handle.net/11427/30880.

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The post 2007-financial crisis era has led to renewed zeal in quantifying market incompleteness when pricing contingent claims. This quantification exercise is necessary in maintaining a stable and sustainable banking operation and thus the XVAs have emerged as the metrics for market incompleteness. This dissertation focuses solely on the capital valuation adjustment (KVA) and aims to use the definition of KVA as set out by Albanese et al. (2016) in an investigation of different numerical techniques for calculating KVA. A single equity forward is considered first, followed by an equity option and then portfolios of options on two underlying assets, with the dissertation ending by considering a practical example on discrete delta and vega-delta hedging an index option. The numerical approaches explored are the binomial tree method and a combination of the crude and quasi-Monte Carlo method.
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Книги з теми "Kv3"

1

Kvazhdy kva. Moskva: Metafora, 2008.

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2

Fux, Johann Joseph. Requiem: K51-K53. Graz: Akademische Druck, 1992.

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3

Williams, Gareth. IT at KS3. 2nd ed. Cambridge: Pearson, 1995.

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4

Goddard, David. KS3 IT activities. Cambridge: Pearson Publishing, 1996.

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5

Goddard, David. Supporting KS3 IT. Cambridge: Pearson Publishing, 1997.

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6

Gardner, V. A. KS3 science homework. Cambridge: Pearson Publishing, 1999.

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7

Gietl, Gerhard, Werner Lobinger, and Dieter Knon. Gewinnsteigerung mit KVP. München: Carl Hanser Verlag GmbH & Co. KG, 2010. http://dx.doi.org/10.3139/9783446426467.

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8

KS3 Science workbook. London: Collins, ., 2006.

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9

Zaloga, Steve. KV-1 & 2 Heavy Tanks 1939-45. Osprey Publishing, 1996.

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Moskva Kva-Kva. Eksmo, 2006.

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Частини книг з теми "Kv3"

1

Bocksteins, Elke. "Kv5, Kv6, Kv8, and Kv9." In Encyclopedia of Signaling Molecules, 2794–802. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101682.

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Bocksteins, Elke. "Kv5, Kv6, Kv8, and Kv9." In Encyclopedia of Signaling Molecules, 1–9. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101682-1.

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Bährle-Rapp, Marina. "KVO." In Springer Lexikon Kosmetik und Körperpflege, 307. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_5736.

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Villars, P., K. Cenzual, J. Daams, R. Gladyshevskii, O. Shcherban, V. Dubenskyy, V. Kuprysyuk, I. Savysyuk, and R. Zaremba. "KN3." In Structure Types. Part 10: Space Groups (140) I4/mcm – (136) P42/mnm, 58. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19662-1_13.

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Villars, P., K. Cenzual, J. Daams, R. Gladyshevskii, O. Shcherban, V. Dubenskyy, V. Kuprysyuk, I. Savysyuk, and R. Zaremba. "KO3." In Structure Types. Part 10: Space Groups (140) I4/mcm – (136) P42/mnm, 85. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19662-1_40.

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6

Lichters, Roland, Roland Stamm, and Donal Gallagher. "KVA." In Modern Derivatives Pricing and Credit Exposure Analysis, 306–9. London: Palgrave Macmillan UK, 2015. http://dx.doi.org/10.1057/9781137494849_21.

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7

Bolding, Molly. "KS3." In The Online Tutor's Toolkit, 132–54. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003211648-12.

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Raab, Wolfgang. "Kapitalverwaltungsgesellschaft (KVG)." In Grundlagen des Investmentfondsgeschäftes, 17–54. Wiesbaden: Springer Fachmedien Wiesbaden, 2018. http://dx.doi.org/10.1007/978-3-658-24155-1_2.

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9

Kostka, Claudia, and Sebastian Kostka. "KVP-Teammeetings." In Der Kontinuierliche Verbesserungsprozess, 99–106. München: Carl Hanser Verlag GmbH & Co. KG, 2013. http://dx.doi.org/10.3139/9783446437449.008.

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DGQ. "Warum KVP?" In KVP – Der Kontinuierliche Verbesserungsprozess, 5–20. München: Carl Hanser Verlag GmbH & Co. KG, 2014. http://dx.doi.org/10.3139/9783446440111.002.

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Тези доповідей конференцій з теми "Kv3"

1

P. Leão, André, Maria Emília L. Tostes, João Paulo A.Vieira, Ubiratan H. Bezerra, Marcelo C. Santos, Ádrea L. de Sousa, Wesley R. Heringer, Murillo A. M. Cordeiro, Juan Carlos H. Paye, and Lucas De Paula A. Pinheiro. "Projeto e Montagem de Laboratório Para Testes Experimentais de Faltas de Alta Impedância em Redes Aéreas de Distribuição." In Congresso Brasileiro de Automática - 2020. sbabra, 2020. http://dx.doi.org/10.48011/asba.v2i1.1434.

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Esse artigo apresenta o projeto e a montagem de um laboratório para testes experimentais de faltas de alta impedância (FAI) em redes aéreas de distribuição. Testes experimentais de FAI em uma instalação elétrica trifásica de média tensão podem ser usados para determinar características e, por conseguinte, modelos matemáticos de FAI. O laboratório pode também ser usado para validação de métodos de detecção de FAI introduzidos como função em relés de proteção. O laboratório é composto essencialmente por um transformador trifásico de 225 kVA - 220 V/13,8 kV, um relé de proteção, uma contatora, disjuntores, elos fusíveis, cabos, TPs, TCs, um transformador trifásico de 75 kVA - 13,8 kV/220 V, cargas elétricas, e as diferentes superfícies de contato como objetos de teste. Nesse artigo, as principais características de FAIs foram levantadas, para diferentes superfícies de contato, por meio de testes experimentais realizados no Laboratório de Alta e Extra Alta Tensão (LEAT) da Universidade Federal do Pará (UFPA), em Belém-PA.
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2

Matsunuma, Takayuki, and Takehiko Segawa. "Tip Leakage Flow Reduction of a Linear Turbine Cascade Using String-Type DBD Plasma Actuators." In ASME Turbo Expo 2018: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/gt2018-76680.

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Tip leakage flow through the small gap between the blade tip of a turbine and the casing endwall reduces the aerodynamic performance. String-type dielectric barrier discharge (DBD) plasma actuators made of silicone printed-circuit board were used for the active control of the tip leakage flow of a linear turbine cascade. Sinusoidal voltage excitation with amplitude varying from 4 kV to 6 kV (peak-to-peak voltage: 8 kVp-p to 12 kVp-p) and fixed frequency of 10 kHz was applied to the plasma actuators. The two-dimensional velocity field in the blade passage was estimated by particle image velocimetry (PIV) under the very low Reynolds number conditions of Re = 7.1 × 103 and 1.42 × 104. The tip leakage flow was reduced by the flow control using plasma actuators. The high turbulence intensity region caused by the tip leakage flow was also reduced. For the quantitative comparisons, the displacement thickness of the absolute velocity distributions was examined. By the flow control of the plasma actuators, the displacement thickness at tip-side gradually decreased as the input voltage increased. Although three types of plasma actuators were used, with thin, thick, and flat electrodes and different ratios of discharge area, the differences in their effect were negligible. The reason for these very small differences in effect is the wide spread of the plasma discharge from the encapsulated electrode in the plasma actuator to the exposed electrode of the blade tip. At the relatively high Reynolds number condition of Re = 1.42 × 104, the effect of the plasma actuator was smaller than that at the lower Reynolds number condition of Re = 7.1 × 103.
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3

Thoma, Jurgen, Benjamin Volzer, Dirk Kranzer, David Derix, Michael Geiss, and Andreas Hensel. "Highly Compact 250 kVA Inverter Stack with 3.3 kV SiC MOSFETs." In 2021 23rd European Conference on Power Electronics and Applications (EPE'21 ECCE Europe). IEEE, 2021. http://dx.doi.org/10.23919/epe21ecceeurope50061.2021.9570608.

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4

Zhao, Tiefu, Liyu Yang, Jun Wang, and Alex Q. Huang. "270 kVA Solid State Transformer Based on 10 kV SiC Power Devices." In 2007 IEEE Electric Ship Technologies Symposium. IEEE, 2007. http://dx.doi.org/10.1109/ests.2007.372077.

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5

Nie, Cheng, Xingxuan Huang, Dingrui Li, Shiqi Ji, Min Lin, Ruirui Chen, Fred Wang, Leon M. Tolbert, and William Giewont. "A 13.8 kV, 100 kVA Multi-functional MMC-Based Asynchronous Microgrid Power Conditioning System with 10 kV SiC MOSFETs." In 2021 IEEE Applied Power Electronics Conference and Exposition (APEC). IEEE, 2021. http://dx.doi.org/10.1109/apec42165.2021.9487381.

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6

Palmer, James, Shiqi Ji, Xingxuan Huang, Li Zhang, William Giewont, Fred Fei Wang, and Leon M. Tolbert. "Testing and Validation of 10 kV SiC MOSFET Based 35 kVA MMC Phase-leg for Medium Voltage (13.8 kV) Grid." In 2019 IEEE Energy Conversion Congress and Exposition (ECCE). IEEE, 2019. http://dx.doi.org/10.1109/ecce.2019.8912959.

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7

Choi, Heungsik, Gyeongsik Yang, Kyungwoon Lee, and Chuck Yoo. "KVS." In SoCC '17: ACM Symposium on Cloud Computing. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3127479.3131615.

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8

Gopalan, R., A. M. Al-Jumaily, and P. Leece. "An Investigation Into the Drying of Distribution Transformers Using the Hot Air Vacuum Method." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-1328.

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Abstract A hot air vacuum method with considerable difference in design and constructional features as compared with the conventional process of a normal convection oven has been built and operated for drying transformers up to 1000 kVA, 33 kV. Moisture-equilibrium charts for kraft paper were used for designing the drying system. A high temperature air circulation fan placed inside the vacuum chamber simplified the construction and using air ducts directed at the transformer inside the autoclave improved the heat transfer capability and reduced the heating time for the transformer. A dry vacuum pump used for moisture removal eliminated the need for condensing water vapour before exhausting it into the atmosphere. A mathematical model for predicting the heating and vacuum cycle for distribution transformers in the autoclave has been presented with reasonably accurate results. Experimental results give a 1% or less moisture content in the insulation after dryout in about 10–12 hours. This indicates energy savings over a conventional air circulation process of about 70%.
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9

Tajyuta, Toshihisa, Laxman Maharjan, Koji Maruyama, Akio Toba, Akio Suzuki, Hiroshi Shinohara, and Tomomi Kaneko. "Performance of the 6.6-kV 200-kVA Transformerless SDBC-Based STATCOM Using 3.3-kV SiC-MOSFET Modules for Reactive-Power Compensation." In 2020 IEEE Applied Power Electronics Conference and Exposition (APEC). IEEE, 2020. http://dx.doi.org/10.1109/apec39645.2020.9124271.

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10

Eiras, Rodrigo S. V., Rodrigo S. Couto, and Marcelo G. Rubinstein. "Avaliação de Desempenho de um Proxy HTTP Implementado como Função Virtual de Rede." In Simpósio Brasileiro de Redes de Computadores e Sistemas Distribuídos. Sociedade Brasileira de Computação - SBC, 2018. http://dx.doi.org/10.5753/sbrc.2018.2402.

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Virtualização de funções de rede é um paradigma em que serviços de rede são virtualizados sobre hardware genérico. Nessa abordagem, um dos principais desafios é o desempenho quando comparado com o das soluções dedicadas. Este trabalho avalia o desempenho de um proxy HTTP em duas soluções de virtualização, o KVM e o Docker. Os resultados mostram que o Docker possui desempenho superior ao do KVM, apresentando tempos de processamento do proxy mais próximos ao de uma solução sem virtualização. Entretanto, quando um maior isolamento é necessário, o KVM é mais adequado. Nessa linha, este trabalho mostra que a para-virtualização do KVM melhora significativamente o desempenho, mas não o suficiente para superar o Docker.
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Звіти організацій з теми "Kv3"

1

Kozlovsky, Evgen O., та Hennadiy M. Kravtsov. Мультимедийная виртуальная лаборатория по физике в системе дистанционного обучения. [б. в.], серпень 2018. http://dx.doi.org/10.31812/0564/2455.

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Research goals: the description of technology of software development in Physics Virtual Laboratory for Distance Learning System. Research objectives: the architecture of client and server parts of the lab, the functionality of the system modules, user roles, as well as the principles of virtual laboratory use on a personal computer. Object of research: the distance learning system “Kherson Virtual University”. Subject of research: virtual laboratory for physics in the distance learning. Research methods used: analysis of statistics and publications. Results of the research. The development of the software module “Virtual Lab” in distance learning system “Kherson Virtual University” (DLS KVU) applied to the problems of physics on topics kinematics and dynamics. The information technology design and development, the structure of the virtual laboratory, and its place in the DLS KVU are described. The principal modes of the program module operation in the system and methods for its use in the educational process are described. The main conclusions and recommendations. The use of this software interface allows teachers to create labs and use them in their distance courses. Students, in turn, will be able to conduct research, carrying out virtual laboratory work.
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Mangum, B. W. CCT-K3 :. Gaithersburg, MD: National Bureau of Standards, 2002. http://dx.doi.org/10.6028/nist.tn.1450.

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3

Urata, G. V., and J. O. Franchi. 25-KVA Amorphous Metal-Core Transformer Developmental Test Report. Fort Belvoir, VA: Defense Technical Information Center, August 1989. http://dx.doi.org/10.21236/ada215444.

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4

Babicheva, Irina. Presentation and script for the student mathematical KVN "Relaxing with mathematics". Science and Innovation Center Publishing House, November 2020. http://dx.doi.org/10.12731/presentation_and_script.

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Анотація:
Презентация и сценарий для студенческого математического КВН «Отдыхаем с математикой» демонстрируют один из возможных вариантов проведения данного мероприятия. Материалы разработаны для оказания методической поддержки организаторам предметных КВН. В математическом КВН могут участвовать две и более команд по 5-7 человек в каждой. КВН составлен из 10 конкурсов: «Визитная карточка», «Биатлон», «Математики шутят», «Ба! Знакомые все лица!», «Шифровальщики», «Эрудицион», «Математика танцует», «Черный ящик», «Перевертыши» и домашнее задание на тему «Как я люблю математику». Все конкурсы сопровождаются музыкой, встроенной в слайды презентации. Условия проведения конкурсов , содержание, критерии оценивания вынесены на слайды и прописаны в сценарии. Ответы к конкурсам имеются в сценарии КВН. Положение о проведении мероприятия также представлено в сценарии. Продолжительность игры – 2 часа. Для работы жюри разработана судейская таблица. Предлагаемые конкурсы легко адаптировать для проведения КВН по другим дисциплинам, на их базе придумывать новые. Все зависит от задумки и творчества организаторов этой игры.
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5

Page, R., T. Weiland, and J. Folta. Characterization of BG28 and KG3 filter glass for Drive Diagnostic Attenuators. Office of Scientific and Technical Information (OSTI), November 2007. http://dx.doi.org/10.2172/924016.

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6

Shadurdyyev, G. Analysis of sets of factors affecting the variable flow of the Amu Darya River to create a seasonal prognostic model. Kazakh-German University, December 2022. http://dx.doi.org/10.29258/dkucrswp/2022/53-72.eng.

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The Amu Darya River is a transboundary river whose flow of the river in high-water years reaches up to 108 km3 and in low-water years up to 47 km3 and these are huge fluctuations in the water flow of the river for Tajikistan, Kyrgyzstan, Uzbekistan, Turkmenistan, and Afghanistan, that share water among themselves. The point to consider is that the downstream countries Turkmenistan and Uzbekistan (and possibly Afghanistan in the future) use a lot of water for irrigation, and therefore these countries are the ones most in need of an accurate forecast of the volume of water for the upcoming season. An accurate forecast of the volume of water on the seasonal scale is necessary for better planning of the structure of crops, and subsequently water use in the irrigation of crops. An acceptable solution to this challenge is the construction of an empirical time series model that will be used to predict the seasonal flows of the Amu Darya River to improve the planning and management of water resources in downstream countries. This article considers three important discharge time series in the larger Amu Darya Basin. These include the Kerki Gauge on the Amu Darya, Darband Gauge on Vaksh River and Khorog Gauge on Gunt River. Long-term time series from these stations are available for the study of the development and implementation of time-series based models for the prediction of discharge in the basin. At this stage, we attempt to demonstrate a proof-of-concept which can in a second step convince stakeholders to share such type of discharge data operationally for more effective water allocation between sectors and countries. All our work was carried out with the quantitative tools R/RStudio and QGIS. It can serve as a stepping stone for more complex forecasting models in the future.
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Perrin, Nancy, Rajinder Pal Aggarwal, and T. Daniel Bracken. Survey of Magnetic Fields Near BPA 230-kV and 500-kV Transmission Lines. Office of Scientific and Technical Information (OSTI), May 1991. http://dx.doi.org/10.2172/5176274.

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8

Smith, J. A. Loss of 115 kV Power. Office of Scientific and Technical Information (OSTI), August 2001. http://dx.doi.org/10.2172/785212.

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Berger, M. Calculation of electron emission from a tantalum foil irradiated by 100-kV and 50-kV x-rays. Office of Scientific and Technical Information (OSTI), March 1998. http://dx.doi.org/10.2172/585067.

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Parsa, Z. Booster Parameter List with 40 Kv RF Voltage. Office of Scientific and Technical Information (OSTI), March 1986. http://dx.doi.org/10.2172/1150401.

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