Добірка наукової літератури з теми "Insulin metabolism"
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Статті в журналах з теми "Insulin metabolism":
Ukkola, O. "Ghrelin and insulin metabolism." European Journal of Clinical Investigation 33, no. 3 (March 2003): 183–85. http://dx.doi.org/10.1046/j.1365-2362.2003.01112.x.
Duckworth, William C., Frederick G. Hamel, and Daniel E. Peavy. "Hepatic metabolism of insulin." American Journal of Medicine 85, no. 5 (November 1988): 71–76. http://dx.doi.org/10.1016/0002-9343(88)90399-3.
Heesom, K. J., M. Harbeck, C. R. Kahn, and R. M. Denton. "Insulin action on metabolism." Diabetologia 40 (September 19, 1997): S3—S9. http://dx.doi.org/10.1007/s001250051388.
Beardsall, Kathryn, Barbro M. S. Diderholm, and David B. Dunger. "Insulin and carbohydrate metabolism." Best Practice & Research Clinical Endocrinology & Metabolism 22, no. 1 (February 2008): 41–55. http://dx.doi.org/10.1016/j.beem.2007.10.001.
Heesom, K. J., M. Harbeck, C. R. Kahn, and R. M. Denton. "Insulin action on metabolism." Diabetologia 40, S3 (March 1997): B3—B9. http://dx.doi.org/10.1007/bf03168179.
Harned, Leighton Kahle, and Edward Chin. "PSUN278 Factitious hypoglycemia, diagnostic delay due to insulin assay failure to detect insulin analogues." Journal of the Endocrine Society 6, Supplement_1 (November 1, 2022): A403. http://dx.doi.org/10.1210/jendso/bvac150.838.
Kagotho, Elizabeth. "Insulin-Mediated Glucose Metabolism: An Atherogenic Lipid Profile of Fructose Consumption." Endocrinology and Disorders 2, no. 2 (February 27, 2018): 01–02. http://dx.doi.org/10.31579/2640-1045/096.
Kagotho, Elizabeth. "Insulin-Mediated Glucose Metabolism: An Atherogenic Lipid Profile of Fructose Consumption." Endocrinology and Disorders 2, no. 2 (February 15, 2018): 01–02. http://dx.doi.org/10.31579/2640-1045/021.
Kusters, Yvo H. A. M., and Eugene J. Barrett. "Muscle microvasculature's structural and functional specializations facilitate muscle metabolism." American Journal of Physiology-Endocrinology and Metabolism 310, no. 6 (March 15, 2016): E379—E387. http://dx.doi.org/10.1152/ajpendo.00443.2015.
Piloquet, H., V. Ferchaud-Roucher, F. Duengler, Y. Zair, P. Maugere, and M. Krempf. "Insulin effects on acetate metabolism." American Journal of Physiology-Endocrinology and Metabolism 285, no. 3 (September 2003): E561—E565. http://dx.doi.org/10.1152/ajpendo.00042.2003.
Дисертації з теми "Insulin metabolism":
Vidal, Alabró Anna. "Estudi de l’activació de la glucocinasa (GKA456V) en fetge perivenós." Doctoral thesis, Universitat de Barcelona, 2011. http://hdl.handle.net/10803/32022.
Synthetic glucokinase activators have been used in the context of type 2 diabetes therapy, mainly for their insulin secretagogue activity. However, the impact of these drugs on liver GK has not been studied in vivo. Since GK activators and activating GK mutations confer identical kinetic properties to GK, we hypothesize that hepatic overexpression of a mutated form of GK, GKA456V, described in a patient with Persistent Hyperinsulinemic Hypoglycemia of Infancy (PHHI), shall mimic the liver-specific effects of GK-activating drugs. GKA456V was overexpressed in the liver of streptozotocin diabetic mice and also in healthy mice. Metabolite profiling in serum and liver extracts, together with key components of glucose and lipid homeostasis, were analyzed and compared to GK wild-type transfected animals. Cell compartmentalization of mutant and wild-type GK was also examined in vivo. In the type 1 diabetic mice, GKA456V overexpression markedly reduced blood glucose in the absence of dislipidemia, in contrast to wild-type GK-overexpressing mice. Enhanced glucose utilization did not correlate with glycogen synthesis or lactate production. PEPCK mRNA was not affected, whereas the mRNA for the catalytic subunit of glucose-6-phosphatase was upregulated ~4-fold in the liver of GKA456V treated animals. Moreover, GKA456V was not translocated to the nucleus after a short fast, confirming that this activating mutation disrupted GKRP regulation. In healthy mice, the overexpression of hepatic GK resulted in insulin resistance. Otherwise, GKA456V overepxressing animals were not insulin resistant. They showed increased mRNA and protein content of the catalytic subunit of glucose-6-phosphatase in the liver, and an idnuction of catabolism in their adipose tissue. Our results validate liver specific GK activation as a strategy for diabetes therapy and provide new insights into the complex GK regulatory network.
Collison, Mary Williamson. "Insulin signalling in insulin resistance and cardiovascular disease syndromes." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366184.
Kershner, David. "Oral Glucose Insulin Secretion Test for Identifying Patients with Insulin Resistance." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5634.
Mashhedi, Haider. "Implicating insulin in neoplastic growth and metabolism." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104681.
Compte tenu de l'accumulation de preuves liant l'obésité à un nombre accru de cancers, il y a un grand intérêt à définir les mécanismes par lesquels l'obésité influe sur la croissance néoplasique. Des niveaux d'insuline élevés sont couramment associés à l'obésité ou au «syndrome métabolique», ce qui fait que le récepteur de l'insuline est considéré comme une cible moléculaire potentiellement importante pour le traitement de certains cancers. Pour étudier les effets de l'atténuation de la signalisation de l'insuline sur la croissance du modèle expérimental du cancer du sein chez la souris, la lignée cellulaire insulino-sensible 4T1 in vivo, nous avons comparé les effets d'une déficience à l'insuline induite par l'alloxan à celle de BMS-536924, un inhibiteur des kinases tyrosine des récepteurs de l'insuline et d'IGF-I. Les deux interventions ont montré une activité anti-néoplasique, mais seulement l'alloxan a présenté une toxicité métabolique. L'inhibition des récepteurs d'insuline n'a occasionné qu'une faible hyperglycémie et le traitement avec BMS-536924 a été bien toléré. Nous avons attribué ce phénomène à des facteurs pharmacocinétiques en mesurant l'accumulation de drogue dans les tissus et pour déterminer si le BMS-536924 abolit l'absorption insulino-dépendante du glucose, nous avons mesuré la quantité de glucose utilisé dans le muscle. Nos données indiquent que la captation insulino-dépendante du glucose par le muscle est restée intacte. Ainsi, la distribution tissu-spécifique du BMS-536924 peut être responsable de l'activité anti-néoplasique sans toxicité métabolique grave, ce qui indique que le ciblage pharmacologique du récepteur de l'insuline dans la maladie néoplasique peut être efficace.Les études épidémiologiques ont montré que les patients diabétiques de type II prenant le médicament metformine (un biguanide) ont un risque réduit de développer un cancer ou d'un taux de mortalité due au cancer plus faible par rapport aux patients diabétiques de type II suivant d'autres thérapies. Nous avons déjà montré que la metformine agit comme un inhibiteur de la croissance des cellules tumorales in vitro en phosphorylant l'AMPK d'une manière dépendante de la dose. Outre l'activation de l'AMPK, qui est observée dans les cellules tumorales in vitro et in vivo, la metformine provoque aussi une diminution des taux d'insuline. Ceci est un effet secondaire de la réduction du taux de glycémie dans un contexte de diabète de type II. La tomographie par émission de positons (TEP ou PET) est une technique d'imagerie qui mesure le taux d'utilisation du glucose par les cellules cancéreuses à l'aide de l'analogue du glucose radiomarqué 18F-2-Fluoro-2-Désoxy-D-Glucose (FDG). Nous étions intéressés par les effets de la metformine sur la captation du glucose par les tumeurs d'adénocarcinome de côlon, MC38, allogreffées chez des souris qui ont été nourris avec une diète à haute teneur énergétique (induisant un phénotype diabétique de type II), ou un régime contrôle. Nos résultats montrent que la metformine abolie l'augmentation des niveaux sériques d'insuline, l'activation du récepteur d'insuline dans les tumeurs ainsi que l'absorption du FDG par les tumeur chez les souris ayant un régime riche en énergie et que la metformine n'a aucun effet sur ces mesures chez les souris ayant une diète contrôle. Ceci suggère que pour un sous-ensemble de néoplasmes, le régime alimentaire et le taux d'insuline influencent l'absorption du glucose par les cellules tumorales ce qui pourrait avoir une pertinence clinique dans les prochaines études clinique visant l'évaluation de l'activité anti-néoplasique de la metformine.
Shmueli, Ehoud. "Glucose metabolism and insulin resistance in cirrhosis." Thesis, University of Newcastle Upon Tyne, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308777.
Laberge, Marie-Kristine. "Nck1 is required for ER stress-induced insulin resistance and regulation of IRS1-dependent insulin signalling." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111950.
Sanderson, Alison Louise. "Regulation of skeletal muscle metabolism." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318615.
Field, Polly Ann. "The effects of insulin resistance on chylomicron metabolism." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302120.
DeAngelis, Anthony Michael. "CEACAM1 : a link between insulin and lipid metabolism." Connect to full text in OhioLINK ETD Center, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1243943993.
"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences." Title from title page of PDF document. Bibliography: p. 57-61, p. 20-145.
Nygren, Jonas. "The sites and mechanisms of postoperative insulin resistance /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2695-6.
Книги з теми "Insulin metabolism":
Markussen, Jan. Human insulin by tryptic transpeptidations of porcine insulin and biosynthetic procursors. Lancaster: MTP Press, 1987.
Markussen, Jan. Human insulin by tryptic transpeptidations of porcine insulin and biosynthetic precursors. Lancaster: MTP Press, 1987.
International Conference on Insulin Action and Diabetes (1987 Calgary, Alta.). Insulin action and diabetes. Edited by Goren H. Joseph, Hollenberg Morley D. 1942-, and Roncari Daniel A. K. New York: Raven Press, 1988.
European Symposium on Metabolism (8th 2002 Padua, Italy). The metabolic syndrome: Diabetes, obesity, hyperlipidemia & hypertension : proceedings of the 8th European Symposium on Metabolism, held in Padua, Italy, between 2 and 5 October 2002. Edited by Crepaldi Gaetano, Tiengo Antonio, and Avogaro Angelo. Amsterdam: Elsevier, 2003.
Kraicer, P. Ṿisut ha-energyah ba-guf: Pereḳ be-endoḳrinologyah. [Tel Aviv]: Maṭkal/Ḳetsin ḥinukh rashi/Gale-Tsahal, Miśrad ha-biṭaḥon, 1985.
Trumbach, Sabine. Glukose-Toleranz und Insulin-Sekretion unter simulierter Schwerelosigkeit. Koln: DFLVR, 1988.
International Smolenice Insulin Symposium (2nd 1992). Dietary lipids and insulin action. New York, N.Y: New York Academy of Sciences, 1993.
European Symposium on Metabolism (6th 1993 Padua, Italy). Diabetes, obesity, and hyperlipidemias, V: The plurimetabolic syndrome : proceedings of the European Symposium on Metabolism, Padova, 24-26 May 1993. Edited by Crepaldi Gaetano, Tiengo Antonio, and Manzato E. Amsterdam: Excerpta Medica, 1993.
Dorrestijn, Jannette. Signal transduction related to the metabolic action of insulin. [Leiden: University of Leiden, 1998.
International Symposium on Insulin Action and Its Disorders (1990 Ōtsu-shi, Japan). Recent advances in insulin action and its disorders: Proceedings of the International Symposium on Insulin Action and Its Disorders, Shiga, 16 May 1990. Edited by Shigeta Yukio 1929-, Kobayashi Masashi Dr, and Olefsky Jerrold M. Amsterdam: Excerpta Medica, 1991.
Частини книг з теми "Insulin metabolism":
Larner, J. "Effects of Insulin on Glycogen Metabolism." In Insulin, 367–84. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-74098-5_16.
Bressler, R., and J. J. Bahl. "Insulin Regulation of Metabolism Relevant to Gluconeogenesis." In Insulin, 451–67. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-74098-5_20.
Frayn, Keith N., and Fredrik Karpe. "Insulin Action on Lipid Metabolism." In Insulin Resistance, 87–103. Chichester, UK: John Wiley & Sons, Ltd, 2005. http://dx.doi.org/10.1002/0470011327.ch3.
Konrad, Daniel, Assaf Rudich, and Amira Klip. "Insulin-Mediated Regulation of Glucose Metabolism." In Insulin Resistance, 63–85. Chichester, UK: John Wiley & Sons, Ltd, 2005. http://dx.doi.org/10.1002/0470011327.ch2.
Hileman, Stanley M., and Christian Bjørbaek. "Central Regulation of Peripheral Glucose Metabolism." In Insulin Resistance, 179–206. Chichester, UK: John Wiley & Sons, Ltd, 2005. http://dx.doi.org/10.1002/0470011327.ch7.
Greenlund, Laura J. S., and K. Sreekumaran Nair. "The Effect of Insulin on Protein Metabolism." In Insulin Resistance, 105–32. Chichester, UK: John Wiley & Sons, Ltd, 2005. http://dx.doi.org/10.1002/0470011327.ch4.
Mathias, Dietger. "Metabolism and Insulin Effect." In Fit and Healthy from 1 to 100 with Nutrition and Exercise, 143. Berlin, Heidelberg: Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-65961-8_67.
Patnaik, Akash, Jason W. Locasale, and Lewis C. Cantley. "Cancer Cell Metabolism." In Insulin-like Growth Factors and Cancer, 245–61. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-0598-6_13.
Guest, Paul C. "Insulin Resistance in Schizophrenia." In Reviews on Biomarker Studies of Metabolic and Metabolism-Related Disorders, 1–16. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-12668-1_1.
Carmena, R., J. F. Ascaso, A. Merchante, and F. J. Ampudia. "Insulin Resistance and Lipid Disorders." In Drugs Affecting Lipid Metabolism, 379–88. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-0311-1_44.
Тези доповідей конференцій з теми "Insulin metabolism":
Senhorinha, Gláucia Maria, Arlys Emanuel Mendes da Silva Santos, and Douglas Daniel Dophine. "The role of metabolic syndrome in Alzheimer’s disease." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.319.
El-fadl, Rihab, Nasser Rizk, Amena Fadel, and Abdelrahman El Gamal. "The Profile of Hepatic Gene Expression of Glucose Metabolism in Mice on High Fat Diet." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0213.
Rad, Milad Ghiasi, Aditya Immaneni, Megan McCabe, Massimiliano Pierobon, and Juan Cui. "A simulation model of glucose-insulin metabolism and implementation on OSG." In 2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2017. http://dx.doi.org/10.1109/bibm.2017.8217939.
Staal, Odd Martin, Anders Lyngvi Fougner, Steinar Saelid, and Oyvind Stavdahl. "Glucose-insulin metabolism model reduction and parameter selection using sensitivity analysis." In 2019 American Control Conference (ACC). IEEE, 2019. http://dx.doi.org/10.23919/acc.2019.8814949.
Wardelmann, K., M. Rath, JP Castro, S. Blümel, M. Schell, R. Hauffe, C. Chudoba, et al. "Central acting Hsp10 regulates mitochondrial function, insulin sensitivity and impacts liver metabolism." In Diabetes Kongress 2021 – 55. Jahrestagung der DDG. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1727356.
Campos, L. M., A. G. Rius, D. Kirovski, J. A. D. R. N. Appuhamy, T. F. V. Bompadre, and M. D. Hanigan. "Mammary gland amino acid affinity in response to different levels of dietary protein and insulin." In 6th EAAP International Symposium on Energy and Protein Metabolism and Nutrition. The Netherlands: Wageningen Academic Publishers, 2019. http://dx.doi.org/10.3920/978-90-8686-891-9_120.
Diniz, Clebiana Alves e. silva, Poliana Silva de Brito, Tainan de Andrade Rocha, Suzana Maria de Oliveira Costa Meneses, and Julia Maria Pacheco Lins Magalhães. "Elderly people with diabetes: an analysis of the factors that are associated with lower limb amputation." In II INTERNATIONAL SEVEN MULTIDISCIPLINARY CONGRESS. Seven Congress, 2023. http://dx.doi.org/10.56238/homeinternationalanais-028.
Mougiakakou, Stavroula G., Aikaterini Prountzou, Dimitra Iliopoulou, Konstantina S. Nikita, Andriani Vazeou, and Christos S. Bartsocas. "Neural Network based Glucose - Insulin Metabolism Models for Children with Type 1 Diabetes." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.260640.
Mougiakakou, Stavroula G., Aikaterini Prountzou, Dimitra Iliopoulou, Konstantina S. Nikita, Andriani Vazeou, and Christos S. Bartsocas. "Neural Network based Glucose - Insulin Metabolism Models for Children with Type 1 Diabetes." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.4398212.
Đokovic, Radojica, Marko Cincovic, Vladimir Kurćubic, Milun D. Petrovic, Miloš Ži Petrovic, Ljiljana Anđušic, and Biljana Anđelic. "HOMEORETSKA REGULACUJA METABOLIČKIH FUNKCIJA KOD KRAVA U PERIPARTALNOM PERIODU." In SAVETOVANJE o biotehnologiji sa međunarodnim učešćem. University of Kragujevac, Faculty of Agronomy, 2021. http://dx.doi.org/10.46793/sbt26.235dj.
Звіти організацій з теми "Insulin metabolism":
Gao, Hui, Chen Gong, Shi-chun Shen, Jia-ying Zhao, Dou-dou Xu, Fang-biao Tao, Yang Wang, and Xiao-chen Fan. A systematic review on the associations between prenatal phthalate exposure and childhood glycolipid metabolism and blood pressure: evidence from epidemiological studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2022. http://dx.doi.org/10.37766/inplasy2022.6.0111.
Research, Gratis. Brown Fat Activation: A Future Treatment for Obesity & Diabetes. Gratis Research, November 2020. http://dx.doi.org/10.47496/gr.blog.01.
Boisclair, Yves R., and Arieh Gertler. Development and Use of Leptin Receptor Antagonists to Increase Appetite and Adaptive Metabolism in Ruminants. United States Department of Agriculture, January 2012. http://dx.doi.org/10.32747/2012.7697120.bard.
Lekhanya, Portia Keabetswe, and Kabelo Mokgalaboni. Exploring the effectiveness of vitamin B12 complex and alpha-lipoic acid as a treatment for diabetic neuropathy. Protocol for systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0167.
yu, luyou, jinping yang, xi meng, and yanhua lin. Effectiveness of the gut microbiota-bile acid pathway (BAS) in the treatment of Type 2 diabetes: A protocol for systematic review and meta analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2022. http://dx.doi.org/10.37766/inplasy2022.7.0117.
Meidan, Rina, and Robert Milvae. Regulation of Bovine Corpus Luteum Function. United States Department of Agriculture, March 1995. http://dx.doi.org/10.32747/1995.7604935.bard.
McGuire, Mark A., Amichai Arieli, Israel Bruckental, and Dale E. Bauman. Increasing Mammary Protein Synthesis through Endocrine and Nutritional Signals. United States Department of Agriculture, January 2001. http://dx.doi.org/10.32747/2001.7574338.bard.
Butler, Walter R., Uzi Moallem, Amichai Arieli, Robert O. Gilbert, and David Sklan. Peripartum dietary supplementation to enhance fertility in high yielding dairy cows. United States Department of Agriculture, April 2007. http://dx.doi.org/10.32747/2007.7587723.bard.