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Добірка наукової літератури з теми "Increase of sensitivity"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 травня 2022

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Статті в журналах з теми "Increase of sensitivity"

Coderre, Terence J., and Ronald Melzack. "Procedures which increase acute pain sensitivity also increase autotomy." Experimental Neurology 92, no. 3 (June 1986): 713–22. http://dx.doi.org/10.1016/0014-4886(86)90311-0.

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&NA;. "Recognition proteins could increase cisplatin sensitivity." Inpharma Weekly &NA;, no. 902 (August 1993): 9. http://dx.doi.org/10.2165/00128413-199309020-00018.

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Woods, Russell L., Joanne M. Wood, and Michelle P. Jack. "Exercise does not increase contrast sensitivity." Clinical and Experimental Optometry 80, no. 5 (September 1997): 173–77. http://dx.doi.org/10.1111/j.1444-0938.1997.tb04877.x.

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Peelen, M., and T. Stein. "Feature-specific predictions increase contrast sensitivity." Journal of Vision 14, no. 10 (August 22, 2014): 1044. http://dx.doi.org/10.1167/14.10.1044.

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Nie, Ji, Adam H. Sobel, Daniel A. Shaevitz, and Shuguang Wang. "Dynamic amplification of extreme precipitation sensitivity." Proceedings of the National Academy of Sciences 115, no. 38 (September 4, 2018): 9467–72. http://dx.doi.org/10.1073/pnas.1800357115.

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A useful starting hypothesis for predictions of changes in precipitation extremes with climate is that those extremes increase at the same rate as atmospheric moisture does, which is ∼7% K−1 following the Clausius–Clapeyron (CC) relation. This hypothesis, however, neglects potential changes in the strengths of atmospheric circulations associated with precipitation extremes. As increased moisture leads to increased precipitation, the increased latent heating may lead to stronger large-scale ascent and thus, additional increase in precipitation, leading to a super-CC scaling. This study investigates this possibility in the context of the 2015 Texas extreme precipitation event using the Column Quasi-Geostrophic (CQG) method. Analogs to this event are simulated in different climatic conditions with varying surface temperature (Ts) given the same adiabatic quasigeostrophic forcing. Precipitation in these events exhibits super-CC scaling due to the dynamic contribution associated with increasing ascent due to increased latent heating, an increase with importance that increases with Ts. The thermodynamic contribution (attributable to increasing water vapor; assuming no change in vertical motion) approximately follows CC as expected, while vertical structure changes of moisture and diabatic heating lead to negative but secondary contributions to the sensitivity, reducing the rate of increase.

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Falconbridge, M., L. Shams, and S. Engel. "Adaptation can increase sensitivity to visual features." Journal of Vision 7, no. 9 (March 19, 2010): 356. http://dx.doi.org/10.1167/7.9.356.

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Mitchell, Fiona. "PTEN mutations increase insulin sensitivity and obesity." Nature Reviews Endocrinology 8, no. 12 (October 2, 2012): 698. http://dx.doi.org/10.1038/nrendo.2012.186.

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WOOD, JOANNE M., RUSSELL L. WOODS, and MICHELLE P. JACK. "Exercise Does Not Increase Visual Field Sensitivity." Optometry and Vision Science 71, no. 11 (November 1994): 682–84. http://dx.doi.org/10.1097/00006324-199411000-00002.

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Holloszy, John O. "Exercise-induced increase in muscle insulin sensitivity." Journal of Applied Physiology 99, no. 1 (July 2005): 338–43. http://dx.doi.org/10.1152/japplphysiol.00123.2005.

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Exercise/muscle contraction activates glucose transport. The increase in muscle glucose transport induced by exercise is independent of insulin. As the acute effect of exercise on glucose transport wears off, it is replaced by an increase in insulin sensitivity. An increase in insulin sensitivity results in a shift in the insulin dose-response curve to the left, with a decrease in the concentration of insulin needed to induce 50% of the maximal response. This phenomenon, which plays a major role in rapid muscle glycogen accumulation after exercise, is not mediated by amplification of the insulin signal. Development of the increase in insulin sensitivity after contractions does not require protein synthesis or activation of p38 MAPK. It does require the presence of a serum protein during the period of contractile activity. The effect of exercise on muscle insulin sensitivity is mimicked by hypoxia and by treatment of muscles with 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside to activate AMP-activated protein kinase. The postexercise increase in sensitivity of muscle glucose transport to activation is not specific for insulin but also involves an increased susceptibility to activation by a submaximal contraction/hypoxia stimulus. The increase in insulin sensitivity is mediated by translocation of more GLUT4 glucose transporters to the cell surface in response to a submaximal insulin stimulus. Although the postexercise increase in muscle insulin sensitivity has been characterized in considerable detail, the basic mechanisms underlying this phenomenon remain a mystery.

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Horak, F. B., and F. Hlavacka. "Somatosensory Loss Increases Vestibulospinal Sensitivity." Journal of Neurophysiology 86, no. 2 (August 1, 2001): 575–85. http://dx.doi.org/10.1152/jn.2001.86.2.575.

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To determine whether subjects with somatosensory loss show a compensatory increase in sensitivity to vestibular stimulation, we compared the amplitude of postural lean in response to four different intensities of bipolar galvanic stimulation in subjects with diabetic peripheral neuropathy (PNP) and age-matched control subjects. To determine whether healthy and neuropathic subjects show similar increases in sensitivity to galvanic vestibular stimulation when standing on unstable surfaces, both groups were exposed to galvanic stimulation while standing on a compliant foam surface. In these experiments, a 3-s pulse of galvanic current was administered to subjects standing with eyes closed and their heads turned toward one shoulder (anodal current on the forward mastoid). Anterior body tilt, as measured by center of foot pressure (CoP), increased proportionately with increasing galvanic vestibular stimulation intensity for all subjects. Subjects with peripheral neuropathy showed larger forward CoP displacement in response to galvanic stimulation than control subjects. The largest differences between neuropathy and control subjects were at the highest galvanic intensities, indicating an increased sensitivity to vestibular stimulation. Neuropathy subjects showed a larger increase in sensitivity to vestibular stimulation when standing on compliant foam than control subjects. The effect of galvanic stimulation was larger on the movement of the trunk segment in space than on the body's center of mass (CoM) angle, suggesting that the vestibular system acts to control trunk orientation rather than to control whole body posture. This study provides evidence for an increase in the sensitivity of the postural control system to vestibular stimulation when somatosensory information from the surface is disrupted either by peripheral neuropathy or by standing on an unstable surface. Simulations from a simple model of postural orientation incorporating feedback from the vestibular and somatosensory systems suggest that the increase in body lean in response to galvanic current in subjects with neuropathy could be reproduced only if central vestibular gain was increased when peripheral somatosensory gain was decreased. The larger effects of galvanic vestibular stimulation on the trunk than on the body's CoM suggest that the vestibular system may act to control postural orientation via control of the trunk in space.

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Більше джерел

Дисертації з теми "Increase of sensitivity"

Lasse, Samuel. "Tgif and Smad2 mutations increase mammalian sensitivity to retinoic acid teratogenesis." Connect to this title online, 2005. http://hdl.handle.net/1811/3543.

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Thesis (Honors)--Ohio State University, 2005.
Title from first page of PDF file. Document formattted into pages: contains vi, 43 p.; also includes graphics. Includes bibliographical references (p. 41-43). Available online via Ohio State University's Knowledge Bank.

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Löser, Dana A. "Investigating the mechanisms by which PARP inhibitors increase sensitivity to DNA damaging agents." Thesis, University of Sussex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505912.

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Damage induced by ionising radiation (IR) is mainly repaired by classical non homologous end joining (D-NHEJ), but a small subset of DSBs is repaired with slow kinetics in an ATM (Ataxia telangiectasia mutated) and Artemis dependent manner. In addition, a PARP-1 dependent NHEJ backup pathway (B-NHEJ) was described, which is thought to function in the absence of D-NHEJ. Using ATM, Artemis or DNA ligase IV deficient mouse embryonic fibroblasts (MEFs) as a model system, the effect of the potent and specific PARP-1/-2 inhibitor KU-0059436 upon clonogenic survival after various types of damage that induce different spectra of SSBs and DSBs was measured. In Artemis or ATM deficient MEFs no sensitising effect of KU-0059436 was detected after neocarzinostatin (NCS) treatment; however PARP inhibition increased sensitivity to IR and methylmethane sulphonate (MMS) markedly. In these cell lines no specific single strand break repair (SSBR) defect was observed, and radio-sensitisation by KU-0059436 was replication dependent. Furthermore PARP inhibition led to increased formation of DSBs, an effect which was augmented in Artemis deficient cells. PARP inhibition in DNA ligase IV deficient cells led to increased sensitivity after damage induction to all agents. However, radiosensitisation by KU-0059436 was replication independent. Results show that PARP inhibition increases the dependence on Artemis and ATM after SSB induction, which is consistent with a model whereby DSBs that arise from SSBs during DNA replication in the presence of a PARP inhibitor require ATM and Artemis for their repair. In cells deficient for DNA ligase IV, PARP inhibition causes additional replication independent sensitisation both by abrogating B-NHEJ and promoting accumulation of replication independent DSBs.

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Salisbury, Tonya. "Using globally significant children's literature to increase fourth-grade students' global attitudes and intercultural sensitivity." ScholarWorks, 2010. https://scholarworks.waldenu.edu/dissertations/797.

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It is vital for future generations to clearly grasp what it means to be global citizens in order for them to be successful and for America to maintain its status as a world leader. The purpose of this mixed-method study was to measure and describe the growth of global attitudes and intercultural sensitivity that fourth-grade students acquire through reading and discussing globally significant children's literature which honors and celebrates diversity worldwide, in terms of culture, race, language, religion, and social status. According to Rosenblatt's transactional theory, readers experience aesthetic transactions with the text leading to an understanding of the world around them. The research question involved whether the use of globally significant children's literature created aesthetic transactions and would result in significant changes in fourth-grade students' intercultural sensitivity and global attitudes. Using literature as a catalyst for group discussions and personal responses related to global issues, 23 fourth-grade students participated in a 12-week study. Qualitative data included participants' personal reading response journals and audio taped group literature circle discussions, which were reviewed and coded for evidence of growth in intercultural sensitivity based on Bennett's developmental model of intercultural sensitivity. Two surveys were developed by the researcher to gather quantitative data. A dependent samples, two-tailed, t test at the p < .05 level was used to test the hypothesis that students' global attitudes and intercultural sensitivity would increase after participating in these literature circles. The statistical data gathered showed gains in both areas. It is recommended that teachers at all grade levels utilize globally significant literature and encourage literary exchanges to promote cultural understandings among their students. Developing a mindset of cultural sensitivity in elementary students can have a positive impact on the relationships between individuals and groups representing diverse cultures.

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Krahn, Alexander Philipp. "Hardware development to increase NMR sensitivity and spectral resolution by novel rf resonators and polarization transfer." Lyon, Ecole normale supérieure, 2010. http://www.theses.fr/2010ENSL0561.

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Dans cette thèse, de nouvelles méthodes sont analysées afin d’augmenter la sensibilité, faible, du phénomène d’induction nucléaire grâce l’optimisation de l’instrument lui-même et par le couplage au moyen la Polarisation Dynamique Nucléaire (PDN). La première partie, est axée sur la bobine de mesure en contact avec l’échantillon et le circuit de sonde de RMN de l’état solide sous très hauts champs magnétiques. Le principe de réciprocité et les calculs de champ électromagnétique permettent une description physique des bobines ainsi qu’une optimisation de la géométrie des bobines de mesure. Dans ce contexte la problématique des champs électriques limite auxquels sont soumis les échantillons aux fréquences de Larmor élevées est prise en compte. Ce phénomène a toujours posé de sérieuses difficultés au moment de l’irradiation RF par des impulsions de découplage, cause d’une augmentation sensible de la température des échantillons dispersifs. Pour y remédier, des bobines innovantes, appelées LLC (Loop-gap Loaded Coil), issues de l’analyse numérique de la distribution du champ électromagnétique, sont introduites. Elles réduisent la composante électrique de l’onde électromagnétique dans le volume de l’échantillon. Cette étude est illustrée par la comparaison entre la simulation et l’étude expérimentale réalisée dans un champ statique de 16. 4 T. Dans la seconde partie, des résonateurs adaptés sont présentés pour appliquer la technique de la PDN, afin d’augmenter la polarisation des spins nucléaires par transfert de polarisation à travers le couplage des spins électroniques. Le dispositif expérimental mis en oeuvre relève du défi technique et exige la construction de structures doublement résonantes pour travailler aux fréquences de Larmor de l’électron et du noyau simultanément. Une procédure d’ajustement des modes est détaillée, celui-ci permet le calcul de la distribution du champ électromagnétique l’intérieur des cavités cylindriques, en tenant compte explicitement des propriétés diélectriques de l’échantillon. A partir d’un ensemble de modes dans les cavités résonantes, deux structures possibles sont retenues. Elles présentent des avantages complémentaires pour deux approches différentes expérimentales de la PDN. Des données expérimentales préliminaires sont présentées grâce à un prototype expérimental dans un champ statique 0. 35 T et 3. 5 T
In this thesis, methods are investigated to increase the inherently low detection sensitivity of the NMR experiment by an optimization of the detection hardware and by DNP experiments. In the first part, the emphasis is put on the sample coil and the rf circuitry of the NMR probehead, especially for conditions typical in high-field solid-state experiments. Based on a reciprocity principle and by electromagnetic field calculations, generalized coil parameters are derived and used to optimize the geometry of solenoid sample coils. In this context, the problem of fringe electric fields experienced by a sample at high Larmor frequencies is addressed. In the past, this has put severe limitations on the possibility to apply strong decoupling field amplitudes to temperature sensitive and dispersive samples. Resulting from the numerical field analysis of common NMR coils a novel sample coil geometry – the LLC resonator – is presented that significantly reduces the rf electric field in the sample volume. To characterize the novel structure, a comparative numerical and experimental study for a static field of 16. 4 T is demonstrated. In the second part, dedicated resonators are discussed to apply the method of DNP to increase the nuclear spin polarization by polarization transfer from coupled electron spins. The experimental setup of these experiments is challenging and requires the construction of double resonant structures operated at the electron and nuclear Larmor frequencies. An efficient mode-matching method is implemented that allows the calculation of the electromagnetic field distribution inside cylindrical cavities considering explicitly the dielectric properties of the sample. From the set of cavity modes, two potential resonator geometries are derived that are advantageous for two different experimental DNP approaches. Preliminary experimental data are shown that are measured with prototype resonators in a static field of 0. 35 T and 3. 5 T

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Miller, Matthew P. "Strategies to increase the signal to noise ratio in three-dimensional positron emission tomography." Thesis, University of Surrey, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322456.

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Positron Emission Tomography (PET) is an imaging technique that uses biologically relevant molecules labelled with positron emitting radioisotopes to measure regional tissue function in living organisms. To maximise the detection efficiency, data are acquired in 3D, that is, all possible detector combinations in a scanner without inter-ring shielding (septa). The gain in sensitivity afforded by 3D PET is offset by the increase in random coincidences, scattered coincidences and deadtime. These problems must be overcome for the gain in sensitivity to be fully realised. The aim of this research project was to investigate strategies to increase the signal to noise ratio of the 3D PET data. Additional side shielding, both in neuro and body scanning, has been implemented and assessed. Large gains were achieved using the neuro shields in experimental and clinical studies. The potential of the body shields was tested in experimental and in-vivo studies which showed that they were scan dependent. For example, no gain was found for a cardiac blood flow (H2 IS0) study. A model-based scatter correction was assessed by companng compartment ratios within the 'Utah' phantom with radioactivity outside the field of view, with and without neuroshielding. Recovered ratios were within 6% of their actual values. The integration time was reduced in an effort to decrease the system deadtime. A peak increase of 150/0 in noise equivalent count rate was measured for a uniform cylinder inside the field of view. A random coincidence variance reduction technique was implemented and assessed to reduce the noise contained in the delayed window random coincidence estimate. The algorithm was evaluated using phantoms and tested on clinical data. A mean 16% reduction in coefficient of variation was measured for a C15O torso study.

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Kambavalasa, Sasi Kiran. "Feasibility study to increase the sensitivity of a microwave microstripline bandpass filter based biosensor for the detection of bacteria in water /." abstract and full text PDF (free order & download UNR users only), 2007. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1447811.

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Thesis (M.S.)--University of Nevada, Reno, 2007.
"May, 2007." Includes bibliographical references (leaves 87-89). Online version available on the World Wide Web. Library also has microfilm. Ann Arbor, Mich. : ProQuest Information and Learning Company, [2007]. 1 microfilm reel ; 35 mm.

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Jones, Sandra Joyce. "How an after school environmental science club can increase environmental knowledge: Awareness and sensitivity towards the environment for third and fourth grade students." CSUSB ScholarWorks, 2008. https://scholarworks.lib.csusb.edu/etd-project/3377.

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Children today are disconnected from the natural environment around them, sometimes finding it annoying, lacking in excitement, and little use to them. Their attention and focus are spent inside watching TV, playing games on computers or a variety of other electronic devices. The purpose of this project was to see if after-school exposure to an Enirovnmental Science Club on the school grounds can impact student attitudes toward our local environment and to increase these third and fourth grade students' knowledge and awareness of their environment.

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Gragg, MaryAnne G. "The apparent increase in insulin sensitivity of leptin-treated rats appears to be due to a decrease in blood glucose concentrations in response to fasting l." Auburn, Ala., 2007. http://repo.lib.auburn.edu/07M%20Theses/GRAGG_MARYANNE_23.pdf.

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Moraes, Maria de Lourdes Leite de. "Avaliação comparativa das estratégias para um aumento de sensibilidade em eletroforese capilar." Universidade de São Paulo, 2001. http://www.teses.usp.br/teses/disponiveis/46/46133/tde-15022019-144605/.

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A Eletroforese Capilar (CE) é uma técnica de separação baseada na migração diferenciada de compostos iônicos ou ionizáveis em um campo elétrico, proporcionando alta resolução, eficiência e rapidez de análise. Para preservar a alta resolução, o volume injetado deve ser pequeno (da ordem de nanolitros), o que dificulta a análise de compostos em baixos níveis de concentração. O diminuto caminho óptico definido pelo diâmetro interno do capilar, associado ao pequeno volume injetado, compromete a detecção, principalmente quando se utiliza a absorbância em linha. Várias estratégias têm sido descritas para melhorar a sensibilidade em eletroforese capilar. Neste trabalho, as estratégias de pré-concentração (\"stacking\", amplificação de campo, isotacoforese, cela óptica de alta sensibilidade e extração em fase sólida em linha) foram aplicadas a dois sistemas químicos: o ácido tereftálico (matéria prima importante utilizada na síntese de poliésteres) e o besilato de atracúreo (um agente bloqueador neuromuscular), avaliando-se comparativamente os resultados. O primeiro sistema não se mostrou adequado para tai fim, pois o ácido tereftálico apresenta baixa solubilidade em água, sendo necessário adicionar hidróxido de sódio para dissolvê-lo, o que produzia um meio de alta condutividade, inviabilizando algumas das estratégias de pré-concentração. Porém, como o controle de impurezas no ácido tereftálico é de interesse industrial foi desenvolvido um método para a análise simultânea dos subprodutos principais: o ácido carboxibenzaldeído (4-CBA) e o ácido p-toluóico (pTO), que são controlados industrialmente por polarografia e cromatografia à gás, respectivamente. As análises foram realizadas em lotes industriais do ácido tereftálico cru (CTA) e do ácido tereftálico altamente purificado (PTA). As concentrações de 4-CBA e p-TOL (determinadas por CE) em ambos, CTA e PTA, estão de acordo com as especificações do produto. As análises mostraram a viabilidade da determinação das impurezas, sendo identificados ainda o ácido benzóico (BZ) e o 4-hidroximetilbenzóico (HMB). O segundo sistema químico escolhido, o besilato de atracúreo, foi adequado para avaliar as várias estratégias de pré-concentração, pois este composto é solúvel em água. A apresentação comercial deste produto consiste na mistura de três isômeros (cis-cis, cis-trans e trans-trans), cada um exibindo uma potência bloqueadora neuromuscular particular. Primeiramente foi desenvolvido um método para a separação dos três isômeros por CE e depois foi feito um estudo das impurezas presentes no sistema, avaliando-se a temperatura e o tempo de estocagem. Foram identificadas duas impurezas no composto: a laudanosina e o monoquaternário ácido. Foi escolhido o pico da laudanosina para avaliar as estratégias de aumento de sensibilidade devido este ser o principal composto de decomposição do atracúreo. O aumento de sensibilidade foi calculado em termos de ganho em sinal-ruído (S/R). O melhor resultado de aumento de sensibilidade para o \"stacking\" mediado por força iônica foi quando se dissolveu a amostra em água e comparou-se à mesma amostra dissolvida no tampão de corrida (o ganho em S/R foi da ordem de 25 vezes). Para as demais estratégias, a referência de partida foi uma amostra já dissolvida em água. Dentre todas as estratégias avaliadas, o maior ganho em sensibilidade foi obtido com os pré-concentradores (22,5 vezes de aumento em sinal-ruído (S/R)), mas a dificuldade de confecção não os tornam atrativos para as análises. A isotacoforese proporcionou o segundo maior aumento (7,6 vezes), comparável ao aumento de sensibilidade em campo amplificado (7,5 vezes) quando se utilizou um tampão com alta concentração de sal. Este ganho foi melhor que o da cela HS que teve aumento de 2,9 vezes em SIR, sugerindo que estas técnicas de pré-concentração podem ser utilizadas com vantagem em relação à cela HS proporcionando baixo custo. O aumento de sensibilidade não foi tão expressivo no \"stacking\" por injeção de grande volume (1,1), mas pode ser melhorado se o capilar inteiro for preenchido com a amostra.
Capillary Electrophoresis (CE) is a separation technique based on differential migration of ionic compounds in a electric field, providing high efficiency, resolution and faster analysis. To preserve high resolution, the injected volume must be small (nanoliters), which compromises the analysis of samples components in a low concentration level. The little pathlenght defined by the capillary internal diameter and a small injected volume, place a large demand on detection, especially when on-line absorbance detectors is used. Some strategies have been described to improve the capillary electrophoresis sensitivity. At this work, preconcentration techniques (stacking, field amplification, isotachophoresis, high sensitivity optical cell, and on line solid extraction) were applied to two chemical systems: terephthalic acid (an important raw material used in a polyester synthesis) and atracurium besylate (a neuromuscular blocking agent), and the results were comparatively evaluated. The first selected system was not suitable for this purpose, due to poor solubility of terephthalic acid in water. lt was necessary to work with solutions of crude and purified products prepared in 0.15 mol /L NaOH and that produced a high conductivity medium, jeopardizing some preconcentration techniques. However, since impurities control in terephthalic acid is of industrial interest, it was developed a method to simultaneously analyze major byproducts: 4-carboxybenzaldehyde (4-CBA) and toluoic acid (pTO), industrialy controlled by polarography and gas chromatography, respectively. Analysis were conducted in industrial batches of crude terephthalic acid (CTA) and highly purified terephthalic acid (PTA). Concentrations of 4-CBA and p-TOL, in both, CTA and PTA, were in agreement with product specification. The results showed the viability to determine several impurities using CE. Additionally, two other contaminants, benzoic acid (BZ) and 4-hydroxymethyl benzoic acid (HMB), were identified. The second selected system, atracurium besylate, was useful to evaluate some preconcentration strategies, because of this water solubility and ionic character. Commercial presentation of this pharmaceutical consists in a mixture of three isomers (cis-cis, cis-trans e trans-trans), which one presenting a particular neuromuscular potency. First, it was developed a method to separate the three isomers by CE and then a study of the product impurities was conducted, evaluating the temperature tolerance and shelf life. Laudanosine and a monoquaternary acid were identified impurities in the pharmaceutical. Laudanosine was selected for the evaluation of preconcentration techniques because it is the major decomposition product of atracurium besylate. Sensitivity enhancement was calculated in terms of signal-noise increase (S/R). The best results of enhancement sensitivity with \"stacking\" mediated by ionic strange was obtained when the sample was dissolved in water and it was compared to the same sample dissolved in a running buffer (signal-noise increase was 25 times). To the other strategies, the reference sample was dissolved in water). Among all evaluated strategies, the major sensitivity enhancement was obtained with preconcentrators (22,5 times), but its difficult manufaturing makes them not attractive for routine analysis. Isotachophoresis, the second best in terms of signal-noise (S/R) values (7,6 times), was comparable to field amplification sensitivity enhancement (7,5 times), when buffers with high salt concentration were used. Its enhancement was better than that of HS cell, that was signal-noise increase of 2,9 times), suggesting that these preconcentration techniques can be used with advantage in relation to HS cell providing low cost. Sensitivity enhancement was not expressive, in the large injection volumes strategy (1, 1 times), but it can be improved if the whole capillar1 is filled with sample.

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Benson, Eric Ashley. "Loss of SIMPL increases TNFalpha sensitivity during hematopoiesis." Connect to resource online, 2008. http://hdl.handle.net/1805/1851.

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Thesis (Ph. D.)--Indiana University, 2008.
Title from screen (viewed June 24, 2009). Department of Biochemistry and Molecular Biology, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): Maureen Harrington. Includes vita. Non-Latin script record. Includes bibliographical references (leaves 126-132).

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Книги з теми "Increase of sensitivity"

Levine, Jerome I. Medications that increase sensitivity to light: A 1990 listing. [Rockville, Md.?]: U.S. Dept. of Health and Human Services, Public Health Service, Food and Drug Administration, Center for Devices and Radiological Health, 1991.

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Angus, Douglas E. Consumer sensitivity to increases in the price of magazine subscriptions. [Ottawa]: Coopers & Lybrand Consulting Group, 1986.

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Monteleone, Erminio, and Mario Bertuccioli, eds. Secondo Convegno Nazionale della Società Italiana di Scienze Sensoriali. Florence: Firenze University Press, 2009. http://dx.doi.org/10.36253/978-88-8453-872-7.

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Over the last decade there has been a growing interest in sensory science in Italy. This has clearly resulted in an increase in the number of researchers engaged in this sector and the number of companies that exploit sensory evaluations for product innovation and enhancement and in quality control. In Italy, in the sphere of the valorisation of prestige foodstuffs there is an increasing sensitivity towards the adoption of strict methods for describing the sensory properties of the products and ascertaining compliance with defined sensory standards. The Società Italiana di Scienze Sensoriali has played a decisive role in activating and guiding this development. Pursuing this approach, in 2008 the Society organised the 2nd National Convention as an occasion for exchange among professionals working in the field of sensory science.

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Yobbi, D. K. Testing the sensitivity of pumpage to increases in surficial aquifer system heads in the Cypress Creek well-field area, West-Central Florida: An optimization technique. Tallahassee, Fla: U.S. Dept. of the Interior, U.S. Geological Survey, 2002.

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Hilgers, Lance Jay. Improved methods which increase the reliability and sensitivity of polymerase chain reaction. 1993.

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Cejas, Ivette, and Alexandra L. Quittner. Effects of Family Variables on Spoken Language in Children with Cochlear Implants. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190880545.003.0005.

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This chapter reviews the effects of family variables on spoken language in the largest, longitudinal multisite study of the effects of cochlear implants on young deaf children’s development. Data published to date on 188 deaf and 97 hearing children indicate that parents report high levels of context-specific parenting stress and less sensitivity during parent–child interactions and use fewer higher-level language techniques. Children’s language was related to higher rates of behavior problems, which were associated with higher parenting stress. After implantation, children made impressive gains in spoken language, and these were directly related to maternal sensitivity and use of facilitative language techniques. Our results indicated that cochlear implantation should be accompanied by parenting interventions that increase sensitivity and use of higher-level language strategies and foster a stronger parent–child relationship.

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How, Poh Choo, Pachida Lo, Marjorie Westervelt, and Hendry Ton. Refugees and Immigrants. Edited by Hunter L. McQuistion. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190610999.003.0023.

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The number of refugees and immigrants continues to increase each year. These populations may experience migration-related trauma and stress that increase the risk for mental illness(es). Perspectives about mental illness, its expression, and treatments often differ significantly between immigrants/refugees and their providers. Therefore, psychiatric evaluation requires sensitivity to the patients’ cultural context and perspectives, including the specific stressors associated with being a migrant. Interpreters can be helpful as cultural brokers in the process of forming a collaborative explanatory model and treatment plan. The latter should include psychosocial approaches to help patients identify areas of resiliency and foster post-traumatic growth, as well as social integration and acculturation to the dominant culture while maintaining affiliation with their original culture. This will increase the probability of positive mental health outcomes.

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Wilton, Niall, Brian J. Anderson, and Bruno Marciniak. Anatomy, physiology, and pharmacology in paediatric anaesthesia. Edited by Jonathan G. Hardman and Neil S. Morton. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0069.

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Anaesthesia for children is tempered by changes that occur during both growth and development. Drug dose is affected by size and clearance maturation processes as well as the changing body composition that occurs with age. All organ systems undergo these maturation changes and most are complete within the first few years of life. Normal physiological variables in infancy and childhood are quite different from adults. The central nervous, cardiovascular, and respiratory systems are particularly important. Cerebral immaturity and plasticity impacts sensitivity to drugs, pain responses, and behaviour and increases potential harm from apoptosis with anaesthesia. The heart undergoes a transition from fetal to adult circulation during the first few weeks of life. Undiagnosed congenital defects are not uncommon. The neonate is very susceptible to conditions that trigger an increase in pulmonary vascular resistance, with reversion to fetal circulatory patterns. Respiratory anatomy and mechanics affect the propensity to apnoea, airway maintenance, artificial ventilation modalities, uptake of inhalational agents, and tracheal tube sizes. Metabolic rate and oxygen requirements increase with decreasing age. This physiology influences diverse aspects that include the rate of desaturation during apnoea, hypoglycaemia during starvation, cardiac output, drug metabolism, fluid requirements, and heat production or loss.

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Stoneley, Sarah, and Simon Rinald. Sensory loss. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0047.

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Sensory disturbance can either be a complete loss (anaesthesia) or a reduction (hypoaesthesia) in the ability to perceive the sensory input. Dysaesthesia is an abnormal increase in the perception of normal sensory stimuli. Hyperalgesia is an increased sensitivity to normally painful stimuli, and allodynia is the perception of usually innocuous stimuli as painful. A complete loss of sensation is likely to be due to a central nervous system problem, while a tingling/paraesthesia (large fibre) or burning/temperature (small fibre) sensation is likely due to an acquired peripheral nervous system problem. Shooting, electric-shock-like pains suggest radicular pathology, a tight-band spinal cord dysfunction. Positive sensory symptoms are usually absent in inherited neuropathies, even in the context of significant deficits on examination. This chapter describes the clinical approach to patients with sensory symptoms. Common patterns of sensory loss and their causes are described.

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Räisänen, Jouni. Future Climate Change in the Baltic Sea Region and Environmental Impacts. Oxford University Press, 2017. http://dx.doi.org/10.1093/acrefore/9780190228620.013.634.

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The warming of the global climate is expected to continue in the 21st century, although the magnitude of change depends on future anthropogenic greenhouse gas emissions and the sensitivity of climate to them. The regional characteristics and impacts of future climate change in the Baltic Sea countries have been explored since at least the 1990s. Later research has supported many findings from the early studies, but advances in understanding and improved modeling tools have made the picture gradually more comprehensive and more detailed. Nevertheless, many uncertainties still remain.In the Baltic Sea region, warming is likely to exceed its global average, particularly in winter and in the northern parts of the area. The warming will be accompanied by a general increase in winter precipitation, but in summer, precipitation may either increase or decrease, with a larger chance of drying in the southern than in the northern parts of the region. Despite the increase in winter precipitation, the amount of snow is generally expected to decrease, as a smaller fraction of the precipitation falls as snow and midwinter snowmelt episodes become more common. Changes in windiness are very uncertain, although most projections suggest a slight increase in average wind speed over the Baltic Sea. Climatic extremes are also projected to change, but some of the changes will differ from the corresponding change in mean climate. For example, the lowest winter temperatures are expected to warm even more than the winter mean temperature, and short-term summer precipitation extremes are likely to become more severe, even in the areas where the mean summer precipitation does not increase.The projected atmospheric changes will be accompanied by an increase in Baltic Sea water temperature, reduced ice cover, and, according to most studies, reduced salinity due to increased precipitation and river runoff. The seasonal cycle of runoff will be modified by changes in precipitation and earlier snowmelt. Global-scale sea level rise also will affect the Baltic Sea, but will be counteracted by glacial isostatic adjustment. According to most projections, in the northern parts of the Baltic Sea, the latter will still dominate, leading to a continued, although decelerated, decrease in relative sea level. The changes in the physical environment and climate will have a number of environmental impacts on, for example, atmospheric chemistry, freshwater and marine biogeochemistry, ecosystems, and coastal erosion. However, future environmental change in the region will be affected by several interrelated factors. Climate change is only one of them, and in many cases its effects may be exceeded by other anthropogenic changes.

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Частини книг з теми "Increase of sensitivity"

Bell, John, and Tuquabo Tesfamichael. "Engineering Thin Film Semiconductor Gas Sensors to Increase Sensitivity and Decrease Operation Temperature." In Proceedings of the 8th Pacific Rim International Congress on Advanced Materials and Processing, 1917–28. Cham: Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-48764-9_239.

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de Winder, Ben, and Luuc R. Mur. "The sensitivity for salinity increase in the drought resistant cyanobacterium Crinalium epipsammum SAB 22.89." In Microbial Mats, 117–23. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-78991-5_13.

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Ryan, Maria, Theodore A. Steinberg, and Barry E. Newton. "Evaluation of a Near-Adiabatic Compression Process to Increase Fire Safety Within Oxygen Systems, Focusing on Non-Metals." In Flammability and Sensitivity of Materials in Oxygen-Enriched Atmospheres: 14th Volume, 405–12. 100 Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959: ASTM International, 2016. http://dx.doi.org/10.1520/stp159620150063.

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Brengel-Pesce, Karen, Gérard Bargues, Patrice Morand, and Jean-Marie Seigneurin. "Use of TaqStart Antibody to Increase the Sensitivity of Herpesvirus Quantitative PCR on the LightCycler." In Rapid Cycle Real-Time PCR, 65–71. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-642-59524-0_7.

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Zhang, G. Y., Y. X. Xiao, J. H. Zhang, and J. Y. Luo. "Study on Optimization of Row Spacing Between Steel Arches in Deep Buried Fault Cave Sections." In Lecture Notes in Civil Engineering, 412–29. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-1260-3_38.

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AbstractAs a widely used support form in tunnel support, the support effect of steel arch is influenced by the row distance between steel arches. In F8 fault fracture zone of the North Main Canal of Letan Reservoir in Guangxi, the support system of “steel arch + shotcrete” in this faulted cavern section was equalized with elastic modulus and yield stress by using theoretical analysis and numerical simulation, and the characteristic curves of rock support of deeply buried circular cavern under modified axisymmetric loading were obtained. The sensitivity analysis and optimization study of the spacing between steel arches were conducted by using FLAC3D. The results show that with the increase of steel arch spacing, the cavity wall displacement increases, the support reaction force decreases nonlinearly, and the radial displacement and plastic zone around the cavity continue to increase. When the distance between steel arches >600 mm, the deformation of cavern perimeter changes abruptly and the plastic zone increases significantly. Based on comprehensive analysis, the optimization suggestions of steel arch are proposed.

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Gasparini, Nicole M., Rafael L. Bras, and Gregory E. Tucker. "Numerical Predictions of the Sensitivity of Grain Size and Channel Slope to an Increase in Precipitation." In River Confluences, Tributaries and the Fluvial Network, 367–94. Chichester, UK: John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/9780470760383.ch17.

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Li, Jianbin, Junguang Huang, Huawei Tong, and Shankai Zhang. "Study on Surface Deformation Model Induced by Shield Tunneling Based on Random Field Theory." In Lecture Notes in Civil Engineering, 440–54. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-1260-3_40.

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AbstractBased on the shield tunnel engineering in weathered granite stratum in Xiamen, Stochastic calculations, by combining the random field theory and the finite difference analysis together with Monte Carlo simulation, are used to carry out the change law of the characteristics of surface deformation curve and surface deformation model. Results show that with the increase of the vertical scales of fluctuation, the decrease of the transverse scales of fluctuation or the increase of the coefficient of variation, the low peak distribution characteristics of the location of the maximum surface settlement induced by shield tunneling become more obvious, and the randomness and chaos of the shape of surface deformation curve gradually increase. The diversity of surface deformation model is affected by parameter correlation and randomness. Under the condition of small transverse scales of fluctuation and large vertical scales of fluctuation, the sensitivity of coefficient of variation to surface deformation mode is limited.

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Boyd, I. A., F. I. Sutherl, and J. Ward. "The origin of the increase in the length sensitivity of secondary sensory endings produced by some fusimotor axons." In The Muscle Spindle, 207–14. London: Palgrave Macmillan UK, 1985. http://dx.doi.org/10.1007/978-1-349-07695-6_30.

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Kang, Bin G., Woong June Park, Myung Hee Nam, and Rainer Hertel. "Ethylene-induced increase of sensitivity to auxin in Ranunculus petioles and its implications regarding ethylene action on adaptation." In Progress in Plant Growth Regulation, 248–53. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2458-4_27.

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Park, Hyei Sun, and Minsu Joh. "Climate Change due to the Gradual Increase in Atmospheric CO₂: A Climate System Model Sensitivity Study." In Key Engineering Materials, 595–600. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-958-x.595.

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Тези доповідей конференцій з теми "Increase of sensitivity"

Demoli, Nazif, Kristina Šariri, Ivica Sović, Marc Torzynski, Hanan Halaq, and Dalibor Vukičević. "Sensitivity increase in digital holographic interferometry." In Photonics Europe, edited by Christophe Gorecki, Anand K. Asundi, and Wolfgang Osten. SPIE, 2008. http://dx.doi.org/10.1117/12.781532.

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Vakser, A. I. "Form effect and increase of mm detector sensitivity." In International Conference on Millimeter and Submillimeter Waves and Applications 1994. SPIE, 1994. http://dx.doi.org/10.1117/12.2303180.

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Kharitonov, Eugene, Craig Macdonald, Pavel Serdyukov, and Iadh Ounis. "Using historical click data to increase interleaving sensitivity." In the 22nd ACM international conference. New York, New York, USA: ACM Press, 2013. http://dx.doi.org/10.1145/2505515.2505687.

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Meunier, J. "PRM Techniques can Significantly Increase Time Lapse Sensitivity." In EAGE Workshop on Permanent Reservoir Monitoring (PRM) - Using Seismic Data 2011. Netherlands: EAGE Publications BV, 2011. http://dx.doi.org/10.3997/2214-4609.20145213.

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Leepattarapongpan, Chana, Toempong Phetchakul, Puttapon Pengpad, Arckom Srihapat, Wutthinan Jeamsaksiri, Ekalak Chaowicharat, Charndet Hruanun, and Amporn Poyai. "The increase sensitivity of PNP-magnetotransistor in CMOS technology." In 2014 International Symposium on Integrated Circuits (ISIC). IEEE, 2014. http://dx.doi.org/10.1109/isicir.2014.7029448.

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Kalinowski, Hypolito J., Patricia L. Inácio, Camila C. de Moura, Valmir de Oliveira, and Ismael Chiamenti. "Thermal sensitivity increase of RFBG in the visible range." In Third International Conference on Applications of Optics and Photonics, edited by Manuel Filipe P. Martins Costa. SPIE, 2017. http://dx.doi.org/10.1117/12.2275844.

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Karabanov, Sergey M., Dmitriy V. Suvorov, Gennadiy P. Gololobov, Dmitriy Yu Tarabrin, and Evgeniy V. Slivkin. "Increase of the magnetic sensitivity of magnetically controlled MEMS switches." In 2015 73rd Annual Device Research Conference (DRC). IEEE, 2015. http://dx.doi.org/10.1109/drc.2015.7175581.

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Spornik, Nikolay M., and M. Y. Serenko. "Shadow method of scale with a-posteriori increase of measurements sensitivity." In ECO4 (The Hague '91), edited by Werner P. O. Jueptner. SPIE, 1991. http://dx.doi.org/10.1117/12.47101.

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FIKOS, G., S. SISKOS, A. CHATZIGIANNAKI, and G. SARRABAYROUSE. "A LOW VOLTAGE BIAS TECHNIQUE TO INCREASE SENSITIVITY OF MOSFETS DOSIMETERS." In Papers Presented at MMN 2000. WORLD SCIENTIFIC, 2001. http://dx.doi.org/10.1142/9789812810861_0047.

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RADIL, THOMAS, and C. J. WYSOCKI. "SPONTANEOUS VARIABILITY AND INDUCED INCREASE OF OLFACTORY SENSITIVITY TO DILUTED ODORANTS." In Proceedings of the International School of Biophysics. WORLD SCIENTIFIC, 1998. http://dx.doi.org/10.1142/9789812816887_0014.

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Звіти організацій з теми "Increase of sensitivity"

O'Neill, Sharman, Abraham Halevy, and Amihud Borochov. Molecular Genetic Analysis of Pollination-Induced Senescence in Phalaenopsis Orchids. United States Department of Agriculture, 1991. http://dx.doi.org/10.32747/1991.7612837.bard.

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The project investigated the molecular genetic and biochemical basis of pollination-induced senescence of Phalaenopsis flowers. This experimental system offered unique advantages in that senescence is strictly regulated by pollination, providing the basis to experimentally initiate and synchronize senescence in populations of flowers. The postpollination syndrome in the Phalaenopsis orchid system was dissected by investigating the temporal and spatial regulation of ACC synthase gene expression. In the stigma, pollen-borne auxin induces the expression of the auxin-regulated ACC synthase (PS-ACS2) gene, resulting in ACC synthesis within 1 h following pollination. Newly formed ACC is oxidized by basal constitutive ACC oxidase to ethylene, which then induces the expression of the ethylene-regulated ACC synthase(PS-ACS1) and oxidase (ACO1) genes for further autocatalytic production of ethylene. It is speculated that during the 6-h period following pollination, emasculation leads to the production or release of a sensitivity factor that sensitizes the cells of the stigma to ethylene. ACC and ethylene molecules are translocated from the stigma to the labellum and perianth where ethylene induces the expression of PS-ACS1 and ACO1 resulting in an increased production of ACC and ethylene. Organ-localized ethylene is responsible for inrolling and senescence of the labellum and perianth. The regulation of ethylene sensitivity and signal transduction events in pollinated flowers was also investigated. The increase in ethylene sensitivity appeared in both the flower column and the perianth, and was detected as early as 4 h after pollination. The increase in ethylene sensitivity following pollination was not dependent on endogenous ethylene production. Application of linoleic and linoleic acids to Phalaenopsis and Dendrobium flowers enhanced their senescence and promoted ethylene production. Several major lipoxygenase pathway products including JA-ME, traumatic acid, trans-2-hexenal and cis-3-hexenol, also enhanced flower senescence. However, lipoxygenase appears to not be directly involved in the endogenous regulation of pollination-induced Phalaenopsis and Dendrobium flower senescence. The data suggest that short-chain saturated fatty acids may be the ethylene "sensitivity factors" produced following pollination, and that their mode of action involves a decrease in the order of specific regions i the membrane lipid bilayer, consequently altering ethylene action. Examination of potential signal transduction intermediates indicate a direct involvement of GTP-binding proteins, calcium ions and protein phosphorylation in the cellular signal transduction response to ethylene following pollination. Modulations of cytosolic calcium levels allowed us to modify the flowers responsiveness to ethylene.

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Osadchyi, Viacheslav, Hanna Varina, Evgeniy Prokofiev, Iryna Serdiuk, and Svetlana Shevchenko. Use of AR/VR Technologies in the Development of Future Specialists' Stress Resistance: Experience of STEAM-Laboratory and Laboratory of Psychophysiological Research Cooperation. [б. в.], November 2020. http://dx.doi.org/10.31812/123456789/4455.

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The scientific article deals with the analysis of peculiarities of the use of innovative AR/VR technologies in the process of developing future special- ists’ stress resistance. Based on the analysis of the introduction of AR/VR tech- nologies in the context of the implementation of a competency-based approach to higher education; modern studies on the impact of augmented reality on the emotional states and physiological features of a person in a stressful situation, the experience of cooperation of students and teachers at the Laboratory of Psy- chophysiological Research and STEAM-Laboratory has been described. Within the framework of the corresponding concept of cooperation, an integrative ap- proach to the process of personality’s stress resistance development has been designed and implemented. It is based on the complex combination of tradition- al psycho-diagnostic and training technologies with innovative AR/VR technol- ogies. According to the results it has been revealed that the implementation of a psycho-correction program with elements of AR technologies has promoted an increase of the level of personality’s emotional stability and stress resistance. The level of future specialists’ situational and personal anxiety has decreased; the level of insecurity, inferiority, anxiety about work, sensitivity to failures has also decreased; the level of flexibility of thinking and behavior, ability to switch from one type of activity to another one has increased; general level of person- ality’s adaptive abilities has also increased. The perspectives of further research include the analysis of the impact of AR/VR technologies on the future profes- sionals’ psychological characteristics in order to optimize the process of im- plementing a learner-centered approach into the system of higher education.

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Korber, Bette. The D614G mutation in Spike: increased infectivity and neutralizing Ab sensitivity and the underlying mechanism. Office of Scientific and Technical Information (OSTI), September 2020. http://dx.doi.org/10.2172/1663165.

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Shy, Daniel. A parameter study to optimizing scintillator characteristics for increased sensitivity in nuclear nonproliferation, safeguards, and security based applications. Office of Scientific and Technical Information (OSTI), August 2014. http://dx.doi.org/10.2172/1186744.

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Research, Gratis. Brown Fat Activation: A Future Treatment for Obesity & Diabetes. Gratis Research, November 2020. http://dx.doi.org/10.47496/gr.blog.01.

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Brown fat holds a promising therapeutic approach to prevent obesity and type 2 diabetes by its profound effects on body weight reduction, heat generation, increased insulin sensitivity and glucose metabolism regulation

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Clausen, Jay, Richard Hark, Russ Harmon, John Plumer, Samuel Beal, and Meghan Bishop. A comparison of handheld field chemical sensors for soil characterization with a focus on LIBS. Engineer Research and Development Center (U.S.), February 2022. http://dx.doi.org/10.21079/11681/43282.

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Commercially available handheld chemical analyzers for forensic applications have been available for over a decade. Portable systems from multiple vendors can perform X-ray fluorescence (XRF) spectroscopy, Raman spectroscopy, Fourier transform infrared(FTIR) spectroscopy, and recently laser-induced breakdown spectroscopy (LIBS). Together, we have been exploring the development and potential applications of a multisensor system consisting of XRF, Raman, and LIBS for environmental characterization with a focus on soils from military ranges. Handheld sensors offer the potential to substantially increase sample throughput through the elimination of transport of samples back to the laboratory and labor-intensive sample preparation procedures. Further, these technologies have the capability for extremely rapid analysis, on the order of tens of seconds or less. We have compared and evaluated results from the analysis of several hundred soil samples using conventional laboratory bench top inductively coupled plasma atomic emission spectroscopy (ICP-AES) for metals evaluation and high-performance liquid chromatography (HPLC) and Raman spectroscopy for detection and characterization of energetic materials against handheld XRF, LIBS, and Raman analyzers. The soil samples contained antimony, copper, lead, tungsten, and zinc as well as energetic compounds such as 2,4,6-trinitrotoluene(TNT), hexahydro-1,3,5-triazine (RDX), nitroglycerine (NG), and dinitrotoluene isomers (DNT). Precision, accuracy, and sensitivity of the handheld field sensor technologies were compared against conventional laboratory instrumentation to determine their suitability for field characterization leading to decisional outcomes.

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MALDONADO, KARELYS, JUAN ESPINOZA, DANIELA ASTUDILLO, and WILSON BRAVO. Fatigue and fracture resistance and survival of occlusal veneers of composite resin and ceramics blocks in posterior teeth with occlusal wear: A protocol for a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2021. http://dx.doi.org/10.37766/inplasy2021.10.0036.

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Review question / Objective: The aim of this systematic review is to synthesize the scientific evidence that evaluates fatigue and fracture resistance, survival, and stress distribution, of composite resin CAD/CAM and ceramic CAD/CAM occlusal veneers in posterior teeth with severe occlusal wear. Condition being studied: Currently there is an increase in cases of dental wear, due to several factors such as: excessive consumption of carbonated drinks, a diet high in acids, gastric diseases, anorexia, bulimia, dental grinding, use of highly abrasive toothpastes, or a combination of these(9) (10) (11) (12); which affect the patient in several aspects: loss of vertical dimension, sensitivity due to the exposure of dentin, esthetics, affectation of the neuromuscular system(11) (13) (14). With the advent of minimally invasive dentistry, occlusal veneers have been found to be a valid option to rehabilitate this type of cases and thus avoid greater wear of the dental structure with full coverage restorations. Sometimes when performing a tabletop it is not necessary to perform any preparation, thus preserving the maximum amount of dental tissue(3) (6) (15). Due to the masticatory load either in patients without parafunction where the maximum masticatory force is approximately 424 N for women and 630 N for men or in those who present parafunction where the maximum bite force can vary from 780 to 1120N(7), it is necessary that the occlusal veneers support that load which makes indispensable a compilation of studies investigating both fatigue and fracture resistance and the survival rate of occlusal veneers in different materials and thicknesses.

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Leitner, Gabriel, and Naomi Balaban. Novel Immunotherapeutic Agent for the Treatment and Prevention of Staphylococcal Mastitis in Dairy Cows. United States Department of Agriculture, January 2009. http://dx.doi.org/10.32747/2009.7709880.bard.

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Staphylococci are the most common and costly mammary disease of dairy cattle worldwide. TRAP, a membrane associated 167AA protein, is highly conserved among staphylococci. The aims of this study were to test the safety and efficacy of recombinant TRAP (rTRAP) vaccine in dairy animals. The vaccine was safe as 2-3 subcutaneous injections of rTRAP (54–100μg) with adjuvant ISA 206 to cows and goats did not lead to any abnormal symptoms of sensitivity to the vaccine. The rTRAP vaccine was immunogenic and caused the induction of a humoral immune response that remained high for at least 160 days post second immunization. rTRAP vaccine also elicited a cell-mediated immune response (memory CD4+ and CD8+ T cells), as determined by lymphocyte proliferation assays. The rTRAP vaccine was efficacious as at parturition, only 13.5% heifers in the immunized group were infected with Staphylococcus chromogenes as compared to 42.9% in the non immunized group. Additionally, when cows were immunized in mid-lactation, the difference between somatic cell count (SCC) in immunized and control animals was profound (45±7 vs. 470±194, respectively). At the same time, the difference in milk yield was also evident (48.3±1.4 vs. 44.3±0.9 l/day, respectively). Put together, these studies indicate the value of the rTRAP vaccine in preventing new udder infections by staphylococci, which significantly lead to lowered SCC and some increase in milk yield. TRAP is conserved among all strains and species and is constitutively expressed in any strain of S. aureus or CNS tested so far, including those isolated from cows. TRAP may thus serve as a universal anti-staphylococcus vaccine.

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Driscoll, Donald D. Development and Performance of Detectors for the Cryogenic Dark Matter Search Experiment with an Increased Sensitivity Based on a Maximum Likelihood Analysis of Beta Contamination. Office of Scientific and Technical Information (OSTI), May 2004. http://dx.doi.org/10.2172/875531.

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