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Добірка наукової літератури з теми "Immunoglobulins"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 29 липня 2024

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Статті в журналах з теми "Immunoglobulins"

Markina, Yuliya V., Elena V. Gerasimova, Alexander M. Markin, Victor Y. Glanz, Wei-Kai Wu, Igor A. Sobenin, and Alexander N. Orekhov. "Sialylated Immunoglobulins for the Treatment of Immuno-Inflammatory Diseases." International Journal of Molecular Sciences 21, no. 15 (July 31, 2020): 5472. http://dx.doi.org/10.3390/ijms21155472.

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Immunoglobulins are the potent effector proteins of the humoral immune response. In the course of evolution, immunoglobulins have formed extremely diverse types of molecular structures with antigen-recognizing, antigen-binding, and effector functions embedded in a single molecule. Polysaccharide moiety of immunoglobulins plays the essential role in immunoglobulin functioning. There is growing evidence that the carbohydrate composition of immunoglobulin-linked glycans, and especially their terminal sialic acid residues, provide a key effect on the effector functions of immunoglobulins. Possibly, sialylation of Fc glycan is a common mechanism of IgG anti-inflammatory action in vivo. Thus, the post-translational modification (glycosylation) of immunoglobulins opens up significant possibilities in the diagnosis of both immunological and inflammatory disorders and in their therapies. This review is focused on the analysis of glycosylation of immunoglobulins, which can be a promising addition to improve existing strategies for the diagnosis and treatment of various immuno-inflammatory diseases.

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Okamoto, Yasuyuki, Noboru Hamada, Toshimichi Fujisawa, Jaeduk Noh, Junichi Yamakawa, Mariko Ohno, Kunihiko Ito, and Hirotoshi Morii. "Why no simple relationship between thyroid peroxidase activity-inhibiting immunoglobulins and thyroid function in autoimmune thyroid disease?" Acta Endocrinologica 124, no. 4 (April 1991): 442–48. http://dx.doi.org/10.1530/acta.0.1240442.

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Abstract. We have reported that some anti-thyroid peroxidase antibodies inhibit the activity of thyroid peroxidase in vitro. These thyroid peroxidase activity-inhibiting immunoglobulins seem to inhibit thyroid function in some patients, but the relationship between thyroid peroxidase activity-inhibiting immunoglobulins and thyroid function is not simple. We designed this study to explore this lack of a simple relationship. We stained immunoglobulin G deposits by immunofluorescence staining or the peroxidase-antiperoxidase method, and stained endogenous thyroid peroxidase activity by enzyme histochemistry in thyroid sections. When cryostat thyroid sections were incubated with thyroid peroxidase activity-inhibiting immunoglobulins, immunoglobulin G deposits were seen as lines of stain on the apical border and as intracellular staining, and endogenous thyroid peroxidase activity was inhibited. In paraffin-embedded thyroid sections from 5 Hashimoto's patients and 6 Graves' patients, immunoglobulin G deposits were not found on the apical border of the follicular epithelium. In frozen thyroid sections from 22 Graves' patients, no clear deposits of immunoglobulin G on this apical border were seen. In organ-cultured thyroid slices incubated with thyroid peroxidase activity-inhibiting immunoglobulins, endogenous thyroid peroxidase activity was not inhibited. In conclusion, thyroid peroxidase activity-inhibiting immunoglobulins may reach its antigen only with difficulty. This is one of the reasons why no simple relationship is observed between thyroid peroxidase activity-inhibiting immunoglobulins and thyroid function.

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Almaghlouth, Ibrahim, Sindhu R. Johnson, Eleanor Pullenayegum, Dafna Gladman, and Murray Urowitz. "Immunoglobulin levels in systemic lupus erythematosus: A narrative review." Lupus 30, no. 6 (March 28, 2021): 867–75. http://dx.doi.org/10.1177/09612033211004714.

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Immunoglobulins play a fundamental role in the protection of the human body against internal and external threats. They also contribute to the immune system homeostasis and maintenance of self-tolerance. Hypogammaglobulinemia is occasionally encountered in routine clinical practice by rheumatologists. Low levels of immunoglobulins can occur as primary or secondary issues and may predispose patients to various forms of infection. However, the impact of the low immunoglobulin level abnormality varies with the underlying condition. In this narrative review, we shed light on the overall types and functions of immunoglobulins for clinicians. We discuss important principles of immunoglobulin measurements. We then consider the primary and secondary causes of low immunoglobulins with a special focus on hypogammaglobulinemia in patients with systemic lupus erythematosus (SLE).

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DREW, M. D., and B. D. OWEN. "THE PROVISION OF PASSIVE IMMUNITY TO COLOSTRUM-DEPRIVED PIGLETS BY BOVINE OR PORCINE SERUM IMMUNOGLOBULINS." Canadian Journal of Animal Science 68, no. 4 (December 1, 1988): 1277–84. http://dx.doi.org/10.4141/cjas88-143.

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Bovine and porcine serum immunoglobulins were obtained from abattoir blood by sodium polyphosphate fractionation and mixed with sow milk replacer to provide an IgG level of 20 mg mL−1 for diets fed on day 1 and 4 mg mL−1 for diets fed on days 2–14. Control piglets received only sow milk replacer. The control group had a survival rate of 22% compared to 75% for the piglets receiving bovine immunoglobulins and 92% for those receiving porcine immunoglobulins. Diarrhea was more severe in the control group for the first 21 d than in the other two groups. The bovine and porcine groups did not differ in the incidence of diarrhea at any time during the experiment. The average daily gains measured over the 28-d period were significantly different between the three treatments with the controls gaining 83.9 g d−1, bovine immunoglobulin fed piglets 140.6 g d−1 and porcine immunoglobulin fed piglets 169.8 g d−1. Serum immunoglobulins were not detectable until 7 d of age in the controls and the concentration rose to 14.6 mg d−1 on day 21. Porcine immunoglobulins were absorbed to a much higher degree than bovine immunoglobulins. Piglets receiving porcine immunoglobulins had a serum IgG concentration of 19.7 mg d−1 at 1 d of age compared to 5.0 mg d−1 for the bovine treatment piglets. Procine serum immunoglobulins were judged superior to bovine immunoglobulins in providing passive immunity to colostrum-deprived piglets. Key words: Immunoglobulins, colostrum-deprived, piglet, milk replacer

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Goode, N. P., A. M. Davison, G. Gowland, and M. Shires. "Spontaneous glomerular immunoglobulin deposition in young Sprague-Dawley rats." Laboratory Animals 22, no. 4 (October 1, 1988): 287–92. http://dx.doi.org/10.1258/002367788780746232.

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The frequency, age-onset and distribution of spontaneously deposited immunoglobulins (lgs) in glomeruli of Sprague-Dawley rats has been investigated. Groups of rats ( n=10) were examined at 4-7 day intervals from birth (presuckling) until 30 days of age. Findings were compared with circulating immunoglobulin concentrations in each age group. Immunoglobulins were undetectable in immature kidneys of newborn rats. However, as early as 5 days, scanty IgA and IgM deposits were observed predominantly in mesangial areas of mature glomeruli, corresponding to low circulating concentrations of these immunoglobulins. By contrast, glomerular IgG deposits were not observed until 21 days, despite relatively high concentrations of circulating maternal IgG from birth. Mesangial deposition of immunoglobulins increased with age. Absence of complement C3c or electron dense deposits associated with this mesangial localization suggests that immunoglobulins were not deposited as immune complexes. Accumulation of non-phlogogenic immunoglobulins in the mesangium of normal rats supports the concept that the mesangium is constantly perfused by circulating macro-molecules and filtration residues. The results indicate problems of interpretation of the significance of endogenous immunoglobulin deposition in models of experimental glomerulonephritis, even in studies involving weanling rats.

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Srikumaran, S., E. A. Kluever, D. V. Onisk, and K. Hariharan. "Quantitation of bovine immunoglobulins in culture fluids by use of sandwich radioimmunoassay with monoclonal antibodies." American Journal of Veterinary Research 52, no. 2 (February 1, 1991): 243–46. http://dx.doi.org/10.2460/ajvr.1991.52.02.243.

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SUMMARY Bovine immunoglobulin isotype-specific murine monoclonal antibodies were used in sandwich radioimmunoassays to detect and quantitate bovine IgG1, IgG2, IgM, and IgA in culture fluids. The concentrations of bovine immunoglobulins in unknown samples were extrapolated from standard curves generated with bovine monoclonal immunoglobulins. The lowest detection limits for the bovine immunoglobulin isotypes ranged from 65 to 270 ng/ml.

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Westhrin, Marita, Vlado Kovcic, Zejian Zhang, Siv H. Moen, Tonje Marie Vikene Nedal, Albert Bondt, Stephanie Holst, et al. "Monoclonal immunoglobulins promote bone loss in multiple myeloma." Blood 136, no. 23 (December 3, 2020): 2656–66. http://dx.doi.org/10.1182/blood.2020006045.

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Abstract Most patients with multiple myeloma develop a severe osteolytic bone disease. The myeloma cells secrete immunoglobulins, and the presence of monoclonal immunoglobulins in the patient’s sera is an important diagnostic criterion. Here, we show that immunoglobulins isolated from myeloma patients with bone disease promote osteoclast differentiation when added to human preosteoclasts in vitro, whereas immunoglobulins from patients without bone disease do not. This effect was primarily mediated by immune complexes or aggregates. The function and aggregation behavior of immunoglobulins are partly determined by differential glycosylation of the immunoglobulin-Fc part. Glycosylation analyses revealed that patients with bone disease had significantly less galactose on immunoglobulin G (IgG) compared with patients without bone disease and also less sialic acid on IgG compared with healthy persons. Importantly, we also observed a significant reduction of IgG sialylation in serum of patients upon onset of bone disease. In the 5TGM1 mouse myeloma model, we found decreased numbers of lesions and decreased CTX-1 levels, a marker for osteoclast activity, in mice treated with a sialic acid precursor, N-acetylmannosamine (ManNAc). ManNAc treatment increased IgG-Fc sialylation in the mice. Our data support that deglycosylated immunoglobulins promote bone loss in multiple myeloma and that altering IgG glycosylation may be a therapeutic strategy to reduce bone loss.

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Gong, Yuxin, Bo Liao, Dejun Peng, and Quan Zou. "Accurate Prediction and Key Feature Recognition of Immunoglobulin." Applied Sciences 11, no. 15 (July 27, 2021): 6894. http://dx.doi.org/10.3390/app11156894.

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Immunoglobulin, which is also called an antibody, is a type of serum protein produced by B cells that can specifically bind to the corresponding antigen. Immunoglobulin is closely related to many diseases and plays a key role in medical and biological circles. Therefore, the use of effective methods to improve the accuracy of immunoglobulin classification is of great significance for disease research. In this paper, the CC–PSSM and monoTriKGap methods were selected to extract the immunoglobulin features, MRMD1.0 and MRMD2.0 were used to reduce the feature dimension, and the effect of discriminating the two–dimensional key features identified by the single dimension reduction method from the mixed two–dimensional key features was used to distinguish the immunoglobulins. The data results indicated that monoTrikGap (k = 1) can accurately predict 99.5614% of immunoglobulins under 5-fold cross–validation. In addition, CC–PSSM is the best method for identifying mixed two–dimensional key features and can distinguish 92.1053% of immunoglobulins. The above proves that the method used in this paper is reliable for predicting immunoglobulin and identifying key features.

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Lock, R. J., and D. J. Unsworth. "Immunoglobulins and immunoglobulin subclasses in the elderly." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 40, no. 2 (March 1, 2003): 143–48. http://dx.doi.org/10.1258/000456303763046067.

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Background: Published data imply that adult concentrations are achieved for all Ig isotypes and plateau by 15--18 years of age. Recent data, however, suggest that these results are not applicable in the elderly. There are no equivalent data for IgG subclasses. We present reference range data for an elderly UK patient population, for IgG, IgA, IgM and IgG subclasses. Methods: Serum immunoglobulins were reviewed on samples from 1146 patients > 60 years of age and 925 patients aged 18--60 years. Serum IgG subclasses were reviewed on samples from 498 patients >60 years and 484 patients aged 18--60 years. All Igs and subclasses were measured by nephelometry. Reference ranges were derived by probability plotting. Results: Serum median IgG and IgM concentrations are reduced in the elderly (IgG female P < 0·001, IgG male P < 0·03; IgM female P < 0·001, IgM male P < 0·001). Serum IgA concentrations are maintained. Indeed, men showed a slight increase in serum IgA with age ( P = 0·03). Few differences dependent on gender were seen. Median IgM was lower in men in the younger age groups (18--60 years P < 0·001; 61--70 years P = 0·017). IgG2 is reduced in elderly men ( P = 0·002) and IgG, reduced in elderly women ( P = 0·009). Conclusions: We advocate that centres offering these investigations provide local, method-dependent reference ranges, and suggest an approach as to how this might be achieved.

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Walther, Stefanie, Tamara V. Rusitzka, Ulrike S. Diesterbeck, and Claus-Peter Czerny. "Equine immunoglobulins and organization of immunoglobulin genes." Developmental & Comparative Immunology 53, no. 2 (December 2015): 303–19. http://dx.doi.org/10.1016/j.dci.2015.07.017.

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Дисертації з теми "Immunoglobulins"

Das, Mrinmoy. "The regulatory effects of circulating normal immunoglobulins on autophagy and Th17 response." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066153/document.

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Les immunoglobulines circulantes jouent un rôle critique dans l’homéostasie immune en modulant les fonctions des cellules du système immunitaire. Au cours de ma thèse, j’ai exploré les effets régulateurs des immunoglobulines G thérapeutiques (IVIG) et des immunoglobulines A monomériques circulantes (mIgA) sur l’autophagie et les réponses Th17 respectivement. Les IVIg sont une préparation thérapeutique d’IgG normales poolées. Elles ont utilisées comme agent anti-inflammatoire dans le traitement de maladies auto-immunes et inflammatoires variées. Cependant, les mécanismes ne sont pas complètement élucidés et plusieurs mécanismes mutuels et non exclusifs ont été proposés. L’autophagie est un important processus biologique impliquant la dégradation lysosomale des composants cellulaires endommagés et des protéines mal repliées. Il y a plusieurs preuves montrant l’implication de l’autophagie dans les maladies auto-immunes et auto-inflammatoires incluant la découverte de polymorphismes dans des gènes liés à l’autophagie. J’ai montré que l’induction de l’autophagie par les IVIG représente un nouveau mécanisme d’action permettant leur effet thérapeutique dans les maladies auto-immunes et inflammatoires. Les Th17 représentent une cible attractive pour traiter plusieurs maladies inflammatoires et auto-immunes. Malgré le fait qu’elles sont le deuxième anticorps le plus abondant dans la circulation, la function immunorégulatrice des IgA n’est relativement pas explorée. J’ai montré que les IgA monomériques (mIgA) inhibent la différentiation et l’amplification des cellules Th17 humaines et la production de leur cytokine effectrice IL-17A
Circulating immunoglobulins play a critical role in the immune homeostasis by modulating the functions of immune cells. In my thesis, I investigated the regulatory effects of therapeutic immunoglobulin G (IVIG) and circulating monomeric immunoglobulin A (mIgA) on autophagy and human Th17 response respectively. IVIG is a therapeutic preparation of pooled normal IgG. It is used as an anti-inflammatory agent in the treatment of a wide variety of autoimmune and inflammatory diseases. However, the mechanisms are not yet fully elucidated and several mutually non-exclusive mechanisms have been proposed. Autophagy is an important biological process involving lysosomal degradation of damaged cellular components and misfolded proteins. There are several evidences that support the involvement of autophagy in autoimmune and auto- inflammatory disorders including the discovery of polymorphisms in autophagy-related genes. I show that induction of autophagy by IVIG represents a novel mechanism of action in achieving therapeutic effect in autoimmune and inflammatory diseases. Th17 cells represent an attractive target to treat several inflammatory and autoimmune diseases. Despite being second most abundant antibody in the circulation, the immunoregulatory function of IgA is relatively unexplored. I have shown that monomeric IgA (mIgA) inhibits differentiation and amplification of human Th17 cells and the production of their effector cytokine IL-17A

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Almroth, Gabriel. "Immunoglobulins, immunoglobulin subclass-distributions and serologic markers in some renal and systemic disorders /." Linköping : Univ, 2000. http://www.bibl.liu.se/liupubl/disp/disp2000/med646s.pdf.

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Rogers, Kenneth Alton. "Immunoglobulins and Immunoglobulin Fc Receptors in Nonhuman Primates Commonly Used in Biomedical Research." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/biology_diss/6.

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Antibodies neutralize and eliminate pathogens, malignancies, and toxins by acting either alone or in association with Fc receptors which, once engaged, activate the elimination mechanisms of phagocytic cells. Based on structural differences, antibodies are divided into functionally distinct classes (IgM, IgD, IgG, IgE and IgA). Structure-function relationships within these classes are not well characterized. In addition, animal models for the assessment of potential therapeutic strategies for the modulation of the interaction between antibodies and Fc receptors are not established. Nonhuman primates are widely used to model human diseases and, represent excellent in vivo systems for this assessment. Therefore, we have studied nonhuman primate IgD as well as IgG and IgA specific Fc receptors in rhesus macaques, cynomolgus macaques, baboons and sooty mangabeys. IgD genes had not been identified in nonhuman primates nor the IgD receptors characterized in any species. We characterized IgD genes of the four monkey species, as well as chimpanzees and dogs. In contrast to other antibody classes, the IgD hinge regions are highly conserved between human and nonhuman primates, thus indicating a role in Fc receptor binding. In humans, Fc receptors CD16a (natural killer cells) and CD16b (neutrophils) bind IgG1 and IgG3, and CD89 (myeloid cells) binds IgA. To assess ligand binding and glycosylation properties of nonhuman primate CD16a, CD16b, and CD89, we sequenced, cloned, and generated recombinant molecules in a mammalian expression system. Our results verify the presence of CD16a, but not CD16b in nonhuman primates. CD16a is expressed on monocytes and a subpopulation of lymphocytes. In sooty mangabeys, CD16 is also expressed on neutrophils. Recombinant sooty mangabey/baboon CD16a binds to human IgG1 and IgG2, but not IgG3 and IgG4. Monkey CD89 has the same peripheral blood leukocyte expression profiles as humans, and binds human and recombinant macaque IgA. Blocking of N-glycans inhibited expression of CD89, but only marginally CD16a expression. Although extensive similarities of antibody/Fc receptor interactions exist between human and nonhuman primates, several differences must be considered when evaluating therapeutic strategies. However, these differences can be exploited to further characterize the structure-function relationships existing within antibody molecules and respective receptors.

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Teng, Su Fern. "Immunoglobulins binding ligands." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627345.

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Ding, Cheng. "Siglec-G is a negative regulator of NF-[kappa]B activation and has pivotal roles in B-1 cell development and resistance to sepsis /." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1226876722.

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Smith, David G. E. "Activities of anti-lipopolysaccharide immunoglobulins." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/19300.

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Barua, Utpal. "Allergen specific immunoglobulins during pregnancy." Thesis, Sheffield Hallam University, 1993. http://shura.shu.ac.uk/19325/.

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In this study the serum concentration of IgE and IgG4 (total and allergen specific taking Timothy grass pollen as the model allergen) have been investigated prospectively during and after pregnancy in healthy women and women suffering from allergic rhinitis. The results show that the total serum IgG concentration remained unchanged in both groups during pregnancy. There was no significant difference in the serum concentration of IgG 4 between pregnant allergic women and non-pregnant allergic women. Levels of IgG4 were approximately twice as high (p< 0.01) in non-allergic pregnant women compared to the non-allergic nonpregnant control group. Total IgG4 concentrations were similar in allergic and non-allergic women during pregnancy; however, in the non-pregnant state allergic women had significantly (p = 0.017) higher levels of IgG4 than non-allergic women. The results show that both during pregnancy and in the non-pregnant state there was a highly significantly (p< 0.001) greater serum concentration of total IgE in allergic than non-allergic subjects. Although the level of IgE was significantly (p=0.004) lower in pregnancy, the differences are relatively small and seem unlikely to be of great physiological significance. Allergic symptomatology did not correspond to IgE levels during pregnancy. In both the pregnant and non-pregnant women the serum concentration of antigen-specific IgE was highly significantly greater in the allergic than the non-allergic subjects. However, in allergic women, the concentration of antigen-specific IgE was very much lower during pregnancy, at about 6% of the non-pregnant level (p < 0.001). The concentration of antigen-specific IgG4 was also reduced in pregnancy in allergy sufferers, being about half of the level found in the non-pregnant individuals (p < 0.001). There appeared to be an increase in spontaneous first trimester abortion in women who suffered symptoms of allergy. From the case histories of all 418 pregnancies at the Langold Health Centre ante-natal clinic attending between September 1976 and December 1990, 192 were to allergy sufferers and 226 were to normal women. The abortion rate was 16.7% in the allergic group and 5.3% in the normal pregnant women (p < 0.001).

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Jeffrey, Philip D. "The structure and specificity of immunoglobulins." Thesis, University of Oxford, 1989. http://ora.ox.ac.uk/objects/uuid:79bcae45-289d-4401-9916-d719bc2751a4.

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An investigation into the structures of the antigen-binding fragments (Fab) of mouse monoclonal immunoglobulins by X-ray crystallography, is presented. The family of immunoglobulins studied, Gloops 1-5, possess the ability to bind to both the peptide antigen and the parent protein: Hen Egg-white Lysozyme. The Gloop1 and Gloop4 Fabs were generated by proteolytic cleavage of the antibody, and crystallisation trials yielded crystals of uncomplexed Fabs of both species. Attempts to grow Fab:antigen complex crystals proved unsuccessful. Partial purification of the heterogeneous Gloop4 Fab was found to be essential for the success of the crystallisations. Data were collected on crystal forms of Gloop1, Gloop2 and Gloop4 on an area detector. The structures of three Gloop2 crystal forms were solved by the molecular replacement technique, using models consisting of Fab domain pairs. Two of the crystal forms were refined by molecular dynamics methods at maximum resolutions of 3.3Å and 2.8Å, and the third by rigid body methods alone at 3.5Å resolution. Analysis of the Gloop2 structures between the crystal forms and with other Fabs indicated no atypical features in the domains. The elbow bend of the Gloop2 Fabs differed by up to 7°. The relative association of variable and constant domain pairs was also seen to vary between the Fabs. The changes in domain pairing caused significant differences in the relative disposition of the complementarity determining regions (CDRs), although there was no evidence for conformational change within individual CDRs. The Gloop2 combining site is dominated by a groove of approximate dimensions 12Åx9Åx7Å, containing many aromatic side-chains and a pair of glutamic acid residues in analogous positions to a those found in a FabrHen egg-white Lysozyme complex.

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Prinsloo, Earl Adin Gerard. "An investigation of the binding capacities of recombinant domain mutants of the human Polymeric Immunoglobulin Receptor (pIgR)." Thesis, Nelson Mandela Metropolitan University, 2006. http://hdl.handle.net/10948/403.

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The membrane bound glycoprotein, polymeric immunoglobulin receptor (pIgR) is the primary transport molecule of the polymeric immunoglobulins, dimeric IgA and pentameric IgM, across epithelial cells. This process, known as transcytosis, is essential in order to establish immunity at mucosal surfaces. Typically, pIgR binds to the polymeric immunoglobulin at the basolateral surface of the epithelial cell, via five homologous immunoglobulin-like domains of the ectodomain. Binding is covalent to IgA and non-covalent to IgM; the IgM binding varying among species. The pIgR-bound complex is released at the apical surface of the cell after cleavage of pIgR at Arg585, thereafter referred to as secretory component (SC). SC confers protective and immunologic functions to the polymeric immunoglobulin. Free SC, i.e. not complexed with polymeric immunoglobulins, is also known to be released into mucosal secretions; and binds to pathogenic bacteria and bacterial products. It is known that domain I of the ectodomain is the primary domain in the interaction with polymeric immunoglobulins, while domain V is involved in a covalent linkage with IgA. However, little is known of domains II-IV and their role in immunoglobulin binding, particularly to IgM. This study aimed to characterize the binding of recombinant human pIgR domain mutants to polymeric IgM using immunological, biophysical and cell based techniques; thereby allowing greater insight into the contribution of each of the five domains. The unique domain structure allowed for selective amplification of single and multiple domain mutants from cloned human PIGR ectodomain cDNA. Mutants were cloned and expressed in Esherichia coli BL21 (DE3) as inclusion bodies. Recombinant mutant proteins were refolded in vitro by equilibrium gradient dialysis and purified to homogeneity. Equilibrium binding data show significant contributions to specific binding as a factor of domain presence. Binding kinetics determined by biophysical surface plasmon resonance measurements show the interplay between association and dissociation rates as defined by individual domains. In vitro competitive binding studies using the human intestinal carcinoma, HT29, known to constitutively express pIgR, show that the constructed recombinant domain mutants outcompete native pIgR. The level of competition is shown to be dependant on the domains downstream of domain I. The data also confirm the biological activity of the first in vitro refolded recombinant human SC.

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李瑞山 and Shui-shan Lee. "Anti-neutrophil cytoplasmic antibody: a clinical & experimental study." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1993. http://hub.hku.hk/bib/B31981513.

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Книги з теми "Immunoglobulins"

F, Shakib, ed. Autoantibodies to immunoglobulins. Basel: Karger, 1989.

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Slayton, Kaetzel Charlotte, ed. Mucosal immune defense: Immunoglobulin A. New York: Springer, 2007.

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Slayton, Kaetzel Charlotte, ed. Mucosal immune defense: Immunoglobulin A. New York: Springer, 2007.

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Delire, Marcel. Immunoglobulins: Rationale for the clinical use of polyvalent intravenous immunoglobulins. Petersfield, UK: Wrightson Biomedical Pub., 1995.

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Francesco, Dammacco, and International Symposium "Immunoglobulins in Therapy" (1993 : Vienna, Austria), eds. Immunoglobulins in therapy: International Symposium "Immunoglobulins in Therapy", Vienna, November 1993. Marburg: Medizinische Verlagsgesellschaft, 1995.

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C, Howard Gary, and Bethell Delia R, eds. Basic methods in antibody production and characterization. Boca Raton: CRC Press, 2001.

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Paolo, Casali, Silberstein Leslie E, and New York Academy of Sciences., eds. Immunoglobulin gene expression in development and disease. New York: New York Academy of Sciences, 1995.

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Fridman, Wolf Herman, and Catherine Sautès. Cell-Mediated Effects of Immunoglobulins. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4613-1181-2.

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French, M. A. H., ed. Immunoglobulins in Health and Disease. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4169-4.

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1953-, Lee Martin L., and Strand Vibeke, eds. Intravenous immunoglobulins in clinical practice. New York: Dekker, 1997.

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Частини книг з теми "Immunoglobulins"

Gupta, Anil. "Immunoglobulins." In Comprehensive Biochemistry for Dentistry, 585–91. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-1035-5_23.

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Long, Joanna. "Immunoglobulins." In Encyclopedia of Behavioral Medicine, 1150–51. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39903-0_465.

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Boltz, Marie, Holly Rau, Paula Williams, Holly Rau, Paula Williams, Jane Upton, Jos A. Bosch, et al. "Immunoglobulins." In Encyclopedia of Behavioral Medicine, 1039–41. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_465.

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Ward, Tony Milford. "Immunoglobulins." In Proteins and Tumour Markers May 1995, 1217–47. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0681-8_42.

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Long, Joanna. "Immunoglobulins." In Encyclopedia of Behavioral Medicine, 1–2. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4614-6439-6_465-2.

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Felippe, Julia B. "Immunoglobulins." In Interpretation of Equine Laboratory Diagnostics, 273–81. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781118922798.ch46.

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Barisani-Asenbauer, Talin. "Immunoglobulins." In Intraocular Inflammation, 339–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-540-75387-2_26.

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Haeney, M. "Monoclonal Immunoglobulins." In Immunoglobulins in Health and Disease, 143–72. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4169-4_9.

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Zuercher, Adrian W., Mel Berger, Reinhard Bolli, Cédric Vonarburg, Martin Spycher, Amgad Shebl, Rolf Spirig, Christoph Kempf, Fabian Käsermann, and Sylvia Miescher. "Plasma-Derived Immunoglobulins." In Nijkamp and Parnham's Principles of Immunopharmacology, 327–68. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-10811-3_20.

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Goodship, T. H. J., S. M. Mclachlan, T. F. H. Poon, S. Lloyd, M. K. Ward, and D. N. S. Kerr. "Immunoglobulins in CAPD." In Frontiers in Peritoneal Dialysis, 600–603. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-662-11784-2_115.

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Тези доповідей конференцій з теми "Immunoglobulins"

Dichtelmuller, H., and W. Stephan. "IN VIVO AND IN VITRO NEUTRALIZATION OF BACTERIAL TOXINES BY IGM ENRICHED AND CONVENTIONAL I. V. IMMUNOGLOBULINS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644255.

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Severe septic phenomena are caused bybacterial toxins. We therefore investigated the neutralization of toxins derived from Staphylococcus aureus and Pseudcmonas aeruginosa by different i.v. irtmunoglobulin preparations using hemolysis inhibition tests and mouse protection tests. The efficacy of conventional i.v. immunoglobulin containing preparations were compared with an IgM enriched i.v. immunoglobulin (Pentaglobin).For hemolysis inhibition tests sterile filtered supernatant of Staphylococcusaureus was prepared and given to human erythrocytes. When IgM enriched immunoglobulin was added, toxin depended hemolysis was inhibited. By addition of three different i.v. immunoglobulin preparationsno inhibition of hemolysis was observed. In order to confirm these results in vivo, mice were exposed to the toxic supernatant of Staphylococcus aureus intraperitoneally and treated with i.v. immunoglobulins (3.1 mg/animal) 30 min after toxin exposure. Significant protection of toxin exposed animals was achieved by IgM enriched i.v. immunoglobulin (92 % protection) but not by conventional i.v. immunoglobulin (17 % protection). Similar results were obtained when mice were exposed to toxic supernatant of Pseudcmonas aeruginosa instead of Staphylococcus aureus. We therefore conclude, that IgM is essential for neutralization of bacterial toxins and IgM enriched i.v. immunoglobulins are more effective in therapy of severe septic phenomena, compared to conventional i.v. immunoglobulins.

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Toti, F., A. Stierlé, M. L. Wiesel, A. Schwartz, J. M. Freyssinet, and J. P. Cazenave. "PRODUCTION OF ANTIBODIES TO HUMAN VON WILLEBRAND FACTOR IN LAYING HENS. ISOLATION OF IMMUNOGLOBULINS AND APPLICATIONS TO THE DETECTION OF MOLECULAR DEFECTS OF VON WILLEBRAND FACTOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644084.

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Von Willebrand disease (vWD) is an inherited disorder of primary hemostasis caused by deficiency or structural abnormalities of von Willebrand factor (vWF). VWF circulates in plasma and is also present in platelets. Plasma vWF, the carrier protein for factor VIII, is a large multimeric glycoprotein composed of identical subunits linked by disulfide bridges. Plasma and platelet vWF display distinct multimeric electrophoretic patterns. The different vWD subtypes can be classified either by the determination of vWFantigen (vWFíAg) and/or by multimer distribution. Antibodies to human vWF were raised in laying hens by intramuscular injections of purified human vWF. Immunoglobulins were isolated from egg yolks by selective polyethylene glycol and ammonium sulfate precipitations. These antibodies appeared to be monospecific, as they did not react with the plasma proteins of a patient with severe vWD. The pullets received weekly 50 μg vWF for 4 weeks and then had monthly injections. The antibodies occurred as early as the third injection, the yield being 300 to 500 mg of immunoglobulin per week (6-7 eggs). The titre could be constant over periods greater than 1 year. These immunoglobulins to vWF were tested in vWFíAg electroimmunoassays and for the multimer analysis of plasma and platelet vWF by electrophoresis and immunoblotting techniques. In no case could a difference be detected between assays performed with rabbit monospecific antiserum or with yolk immunoglobulins to human vWF. Ten to 12 multimers could be revealed for normal plasma vWF and up to 12 to 14 bands for normal platelet vWF (1.7% agarose). In the case of vWD, the electrophoresis patterns were identical with both antibodies. Thus, antibodies to vWF raised in laying hens are a suitable tool to detect and to characterize vWD. Although they do not interact with protein A, yolk antibodies are certainly advantageous to produce, as they do not contain IgM or IgA. Immunoglobulin fractions can contain up to 10 % of specific antibodies. Since they are available in larger quantities and are easy to isolate, larger homogeneous batches of antibodies can be obtained. This method may easily be applied to develop antibodies to a variety of antigens.

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Krasnoshtanova, Alla, and Alesya Yudina. "PRODUCTION OF ANTIBODIES FROM POULTRY YOLK (IgY) AND INVESTIGATION OF THEIR IMMUNOCHEMICAL PROPERTIES." In GEOLINKS Conference Proceedings. Saima Consult Ltd, 2021. http://dx.doi.org/10.32008/geolinks2021/b1/v3/17.

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"A particularly important aspect of immunology is to develop non-invasive methods of obtaining antibodies which could be a great alternative to traditional ones that based on the harmful procedure of isolation of immunoglobulins from animal blood sera. That’s why the extraction of antibodies from poultry egg yolks (IgY) is the most promising. Due to the fact of variation of IgY structural features that determine the definite immunochemical properties, yolk antibodies in comparison with mammalian immunoglobulins (IgG) does not interact with rheumatoid factor (Rf), contribute to the activation of the complement system, bind to the Fc-receptor (FcR), and also has weak cross-reactivity, which confirms the possibility of their widespread use in medicine and food. Also the presence of phylogenetic distance between chickens and mammalians guarantees immune response against conservative mammalian protein molecules which is highly important for the creation of new generation test systems. The aim of this work is to develop a selective method of producing high-purity immunoglobulin Y preparations from the yolk of chicken eggs. There were adopted selective conditions of isolation of IgY under spontaneous thawing procedure at the room temperature of firstly frozen yolk solution in a sodium-phosphate buffer mixed with water (pH 5.0) in a ratio of 1:6, which leads to receiving a water-soluble fraction further precipitated with the sodium chloride at a concentration of 10% of the solution mass and subsequently concentrated using ultrafiltration with membrane UAM-10, that allows achieving the content of IgY not less than 95% per dry substance in immunoglobulin fraction. It is possible to produce a protein fraction with a protein content of at least 9 g/l. The purity of the immunoglobulin fraction was verified using polyacrylamide gel electrophoresis. The presence of a light chain in the IgY solution was proved to be a low-molecular compound using the method of gel-filtration-chromatography. The immunological activity of IgY was studied with respect to bovine serum albumin (BSA) as an antigen. The enzymatic resistance of IgY against proteolytic enzymes was tested in area of the gastrointestinal tract."

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Corte-lazzo, D., M. Galli, P. Viero, and T. Barbui. "INTERACTION BETWEEN LUPUS ANTICOAGULANT AND PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644230.

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Lupus Anticoagulants (LAC) are IgG or IgM immunoglobulins which interfere with phospholipid-dependent coagulation tests and actively react also with platelet wall phospholipids. This interaction may result in platelet quantitative and qualitative defects. We have examined 10 patients with LAC diagnosed on the basis of the commonly accepted criteria (Working Party reccomandations, 1983). Four had concomitant Systemis Lupus Erythematosus, one Waldenstrom's disease (W. D.) and five no apparently underlying disease. Only the case with W. D. presented bleeding tendency, whereas the others had a history of thrombotic complications. A vei?y striking defect of platelet aggregation by ADP, epinephrine, collagen and arachidonic acid was documented in the case of W. D., who had also a very prolonged bleeding time (>20 minutes) ; ,in this latter case LAC was an IgM. In the others, LAC, identified as IgG immunoglobulins, produced no aggregation abnormalities. On the contrary, serotonin platelet concentration, platelet, plasma and urine Beta-Thromboglobulin contents showed values consistent with a pattern of platelet activation in all cases. IgG immunoglobulins separated from sera of six patients showed LAC activity but no effects on platelet aggregation of a normal PRP, whereas induced secretion of Beta-Thromboglobulin from normal platelets.

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Tivanova, Anastasia S., Maria A. Vorobjeva, Daria S. Novopashina, Anna M. Bezuglova, Alesia A. Fokina, Georgy A. Nevinsky, and Alya G. Venyaminova. "RNA aptamers against autoreactive immunoglobulins assosiated with multiple sclerosis." In XVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112419.

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Istomina, Evgenia, Anna Starshinova, Irina Chernokhaeva, Michail Nazarenko, Sergey Landa, Michail Filatov, and Piotr Yablonskiy. "Assessment of specific immunoglobulins in patients with lung tuberculosis." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa2748.

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Stovickova, J., H. Hulejova, V. Pesakova, and M. Adam. "THU0047 Matrixins, cytokines and adhesive immunoglobulins within osteoarthritic joint." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.844.

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Lawandowski, K., K. Zawilska, M. Komarnicki, and M. Zozulińsks. "PLATELET ASSOCIATED IMMUNOGLOBULINS IN PATIENTS WITH NON - HODGKIN'S LYMPHOMAS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643196.

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Levels of platelet associated IgG and IgM were studied in 42 patients with non-Hodgkin'a lymphomas / NHL / using rocket inaunoelectrophore8i8 in agarose gel . Twenty percent of patients with NHL had elevated PAIgG and fifty percent had elevated PAIgM levels.Both PAIgG and PAIgM ware strongly correlated with the extend of disease . When patients with NHL and elevated PAIgM levels were treated by chemotherapy , PAIgM levels normalized aa tumor load diminished . No similar correlation axsited between response to the therapy and levels of PAIgG in patients with NHL. These data suggest that PAIgM may be useful as a marker for disease activity and may be an early indicator of relapse when measured periodicaly in patients who have completed therapy.

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Ho, T., E. Chow, N. Rezaee, C. Huang, K. Radford, M. Kjarsgaard, N. Calma, et al. "Sputum and Serum Immunoglobulins in Chronic Obstructive Pulmonary Disease." In American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3306.

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Kuzmina, L. P., E. S. Tsidilkovskaya, and A. G. Khotuleva. "CHANGES IN SCREENING MARKERS OF THE IMMUNE STATUS OF WORKERS AT A LEAD RECYCLING PLANT." In The 17th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2023). FSBSI «IRIOH», 2023. http://dx.doi.org/10.31089/978-5-6042929-1-4-2023-1-269-272.

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The problem of the adverse effect of lead on human health currently remains relevant, especially in occupational medicine. One of the targets of the toxic effect of lead is the immune system, which determines the relevance of research aimed at assessing the immune status of workers in contact with lead and its compounds. The purpose of this study was to evaluate changes in the screening markers of the immune status (leukocyte parameters, immunoglobulins of classes A, M, G) in workers of a lead recycling plant. Materials and methods. The main group — 49 employees of the plant for the recycling of lead-containing products with a length of service of 7 (3; 9) years, the control group — 23 men working without contact with harmful occupational factors. A laboratory examination was carried out, including the study of the blood lead level, ALA in the urine, leukocyte counts and immunoglobulins of classes A, M, G. Results. An inverse correlation was found between the level of IgA in workers of a lead recycling plant with length of service (r=–0.393, p=0.005) in the absence of age dependence, with the blood lead level (r=-0.313, p=0.027). Also, the dependence of the levels of immunoglobulins of classes A, M, G on the concentration of ALA in the urine was revealed: at the level of ALA in the urine ≥20 μmol/gCR, the levels of immunoglobulins are significantly lower than at ALA <20 μmol/gCR. Conclusion. The revealed trend towards a decrease in humoral immunity with higher ALA values in the urine, a decrease in IgA with an increase in length of service indicate the effect of lead and its compounds on the state of humoral immunity and determine the significance of studying changes in IgA, IgM and IgG in dynamics in workers of a lead recycling plant for optimization of preventive measures.

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Звіти організацій з теми "Immunoglobulins"

Steplewski, Z., P. Curtis, J. Hainfeld, L. Mausner, R. Mease, and S. Srivastava. Selection and manipulation of immunoglobulins for radionuclide delivery. Office of Scientific and Technical Information (OSTI), December 1992. http://dx.doi.org/10.2172/10139566.

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Hammer, Carrie, Howard Tyler, James A. Roth, and James D. Quigley. Characterization of Reactions to Intravenous Immunoglobulin in Neonatal Calves. Ames (Iowa): Iowa State University, January 2004. http://dx.doi.org/10.31274/ans_air-180814-837.

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Kenney, James J. Transfection of Murine and Human Hematopoietic Progenitors with Rearranged Immunoglobulin Genes,. Fort Belvoir, VA: Defense Technical Information Center, July 1992. http://dx.doi.org/10.21236/ada253974.

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Kenny, James J. Transfection of Murine and Human Hematopoietic Progenitors with Rearranged Immunoglobulin Genes. Fort Belvoir, VA: Defense Technical Information Center, January 1991. http://dx.doi.org/10.21236/ada243424.

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Kenny, James J. Transfection of Murine and Human Hematopoietic Progenitors with Rearranged Immunoglobulin Genes. Fort Belvoir, VA: Defense Technical Information Center, February 1992. http://dx.doi.org/10.21236/ada245750.

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Block, Timothy M., Songming Chen, Anand S. Mehta, and Terry J. Henderson. A Glycoform of Immunoglobulin G (IgG) as an Early Biomarker of Exposure to Nonhuman Substances. Fort Belvoir, VA: Defense Technical Information Center, December 2012. http://dx.doi.org/10.21236/ada570851.

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Fu, Chengcheng, Xiaohong Wang, Bin Wang, Lingjie Xu, and Wenming Chen. The clinical characteristics of immunoglobulin light chain amyloidosis in Chinese population: A systematic scoping review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2021. http://dx.doi.org/10.37766/inplasy2021.9.0086.

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Middlebrooks, Bobby L. Investigation of the Role of Immunoglobulin Classes and Subclasses in Humoral and Mucosal Immunity in Cetaceans. Fort Belvoir, VA: Defense Technical Information Center, June 2005. http://dx.doi.org/10.21236/ada452454.

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Mackey, Katherine, Irina Arkhipova-Jenkins, Charlotte Armstrong, Emily Gean, Johanna Anderson, Robin A. Paynter, and Mark Helfand. Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Rapid Living Review. Agency for Healthcare Research and Quality (AHRQ), March 2021. http://dx.doi.org/10.23970/ahrqepccovidimmunity.

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 Evidence suggests that the majority of adults develop detectable levels of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies following infection with SARS-CoV-2 (moderate strength of evidence* [SoE]).  IgM levels peak approximately 20 days after symptom onset or RT-PCR diagnosis and subsequently decline. IgG levels peak approximately 25 days after symptom onset or RT-PCR diagnosis and may remain detectable for at least 120 days (moderate SoE*).  Almost all adults develop neutralizing antibodies in response to SARS-CoV-2 infection, and these antibodies may remain detectable for at least 152 days (low SoE*).  A small percentage of people do not develop antibodies in response to SARS-CoV-2 infection for reasons that are largely unclear but may be related to less severe disease or absence of symptoms.  Antibody prevalence does not appear to vary by age or sex, but older age may be associated with higher antibody levels (low SoE*). Non-White race may be associated with higher antibody prevalence and levels (low SoE*). COVID-19 severity and presence of symptoms may also be associated with higher antibody prevalence or levels (low SoE*). More evidence is needed to draw stronger conclusions regarding how the antibody response varies by patient characteristics and disease factors.  Studies to date have not established the relationship between the development of antibodies after RT-PCR-diagnosed SARS-CoV-2 infection and the risk of reinfection. Studies based on index serologic testing suggest that the presence of antibodies is associated with a lower risk of a subsequent positive SARS-CoV-2 RT-PCR test.

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Varbanova, Viktoria, Snejina Mihailova, Elissaveta Naumova, and Anastasiya Mihaylova. Distribution of Killer-cell Immunoglobulin-like Receptors (KIR) and their HLA Class I Ligands in the Bulgarian Population. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, July 2020. http://dx.doi.org/10.7546/crabs.2020.07.14.

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