Готові списки джерел за темами / Human B Lymphocyte

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Добірка наукової літератури з теми "Human B Lymphocyte"

Автор: Grafiati
Опубліковано: 11 березня 2023

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Статті в журналах з теми "Human B Lymphocyte"

1

Li, Lijin, Sharon M. Dial, Monika Schmelz, Margaret A. Rennels, and Neil M. Ampel. "Cellular Immune Suppressor Activity Resides in Lymphocyte Cell Clusters Adjacent to Granulomata in Human Coccidioidomycosis." Infection and Immunity 73, no. 7 (July 2005): 3923–28. http://dx.doi.org/10.1128/iai.73.7.3923-3928.2005.

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ABSTRACT The in situ immunologic response in human coccidioidomycosis remains undefined. To explore this further, pulmonary necrotizing coccidioidal granulomata were examined using immunohistochemical staining for lymphocyte subsets and for the cytokines interleukin-10 (IL-10) and gamma interferon (IFN-γ). Discrete perigranulomatous lymphocytic clusters were seen in eight of nine tissues examined. In these tissues, T lymphocytes (CD3+) significantly outnumbered B lymphocytes (CD20+) in the mantle area of the granulomata (P = 0.028), whereas the clusters were composed of roughly equal numbers of T and B lymphocytes. While the number of cells in the mantle expressing IL-10 was similar to those in the perigranulomatous clusters, there were significantly more cells expressing IFN-γ in the mantle than in the clusters (P = 0.037). Confocal microscopy revealed that CD4+ T lymphocytes and B lymphocytes are associated with IL-10 production. CD4+CD25+ T lymphocytes were identified in the perigranulomatous clusters but were not associated with IL-10 production. This is the first report noting perigranulomatous lymphocyte clusters and IL-10 in association with human coccidioidal granulomata and suggests that down-regulation of the cellular immune response is occurring within coccidioidal granulomata.
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2

Tait, Heidi. "Mechanisms behind the induction of Ttc7 transcription during B lymphocyte development(93.35)." Journal of Immunology 184, no. 1_Supplement (April 1, 2010): 93.35. http://dx.doi.org/10.4049/jimmunol.184.supp.93.35.

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Abstract Changes in Ttc7 (tetratricopeptide repeat domain 7) transcription have been associated with changes in B lymphocyte signaling through changes in both the lymphopoietic environment and homeostasis of B lymphocyte development in mice with the Ttc7fsn/fsn(flaky skin) mutation. We have demonstrated that young Ttc7fsn/fsn mice exhibit decreased naive B lymphocyte populations in the bone marrow and spleen as compared to their wild type littermates, and that this disparity is exaggerated with age. The Ttc7fsn/fsn mutation also leads to excessive production of harmful B1b lymphocytes causing autoimmune disease closely related to SLE. This is significant as both autoimmune and aging human populations share similar B lymphocyte profiles. The evaluation of signaling events upstream of Ttc7 transcription will shed light on stage-specific B cell developmental signaling mechanisms in the bone marrow and spleen that cause immunological dysfunction. We have begun to classify B lymphocyte stages at which Ttc7 transcription rates fluctuate in pursuit of these signaling mechanisms. We have found Ttc7 to be transcribed in the bone marrow at early B lymphocyte stages and have evidence that its transcription is repressed at later stages in the spleen. To further support the hypothesis that induction of Ttc7 transcription during B cell development occurs in early B lymphocytes, we have also found that a 1kb segment of the promoter induces a higher rate of transcription in the pre-B 70Z/3 cell line.
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3

Lipsky, P. E., S. Hirohata, D. F. Jelinek, L. McAnally, and J. B. Splawski. "Regulation of Human B Lymphocyte Responsiveness." Scandinavian Journal of Rheumatology 17, sup76 (January 1988): 229–35. http://dx.doi.org/10.3109/03009748809102973.

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4

Uckun, F. M., D. A. Vallera, and S. L. Wee. "B lymphocyte regulation of human hematopoiesis." Journal of Immunology 135, no. 6 (December 1, 1985): 3817–22. http://dx.doi.org/10.4049/jimmunol.135.6.3817.

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Abstract Epstein Barr virus (EBV)-transformed B lymphoblastoid cell lines (BLCL) were derived from seven different individuals. The ability of BLCL supernatants to stimulate hematopoietic colony formation in vitro was tested in a conventional stem cell assay system. Supernatants promoted the growth of single (GM, E, MK) as well as multi-lineage (GEMM) colonies in bone marrow cultures. Our results indicate that EBV-transformed B lymphocytes produce cytokines that affect in vitro stem cell proliferation and differentiation. These studies demonstrate the regulatory potential of activated B lymphocytes in human hematopoiesis.
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5

Mun, Yeung-Chul, Kyoung-Eun Lee, Jung Mi Kwon, Seung-Hyun Nam, Eun Sun Yoo, Yun-Kyung Bae, Seung-Eun Lee, et al. "Establishment of Effective B Lymphocyte Ex Vivo Expansion on Human Cord Blood Using TPO, SCF, FL, IL-4, IL-10, and CD40L." Blood 104, no. 11 (November 16, 2004): 2882. http://dx.doi.org/10.1182/blood.v104.11.2882.2882.

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Abstract In respect to B lymphocyte-mediated immunity, characteristics of human cord blood are low counts of mature B lymphocytes, deficient expression of CD40L and cytokine production in CD4+ T lymphocytes, defect in the isotype switch of immunoglobulin and the activation of B lymphocytes, and low IgG production of B lymphocytes. These characteristics of the B lymphocyte from human cord blood lead to a delayed B lymphocyte-mediated immune reconstitution and an increased susceptibility to infections after a cord blood transplantation. The mechanism of immunological recostitution after cord blood transplantation has been examined from a variety of viewpoints in experimental models as well as clinical studies. However, problems of sustained immunodeficiency after cord blood transplantation remain to be resolved. The aim of the present study is to establish culture conditions that support the effective B lymphocyte expansion of human cord blood using IL-4, IL-10, and CD40L, to which cytokines are defected in B lymphocyte of human cord blood, and established conditions are compared to previously established cytokine combinations, TPO+SCF+FL in our Lab (Br J Haematol 107:176–185, 1999 & Stem Cells 21:228–235, 2003). To elucidate the effective B lymphocyte-mediated immune reconstitution of cord blood after ex vivo expansion, mononuclear cells, separated from density gradient of Ficoll system, and CD34+ purified cells, isolated from immunomicrobead(MiniMACS) system, were cultured with various combinations of cytokines (TPO+FL+SCF and/or IL-4, IL-10 and CD40L) for 2 weeks or 4 weeks. This then allowed for cytometric analysis after immunofluorescence stain with CD34, CD38 (for HSC analysis) and CD19, IgG and IgM (for B lymphocyte-mediated immune reconstitution) and CD4 (for T helper cell) and CD25 (for lymphocyte activation assay) to be performed. In the B lymphocyte expansion aspect, the immunoglobulin expression, and functional activity, expansion with the TPO+FL+SCF+IL-4+IL-10 combination showed best results in the expression of CD19, CD25, IgG, and IgM. However, the addition of CD40L to those culture condition did not increase expression of CD19, CD25, IgG, and IgM after the expansion of human cord blood. Expansion of CD34+ purified cells was superior to MNCs in the expression of CD19, CD25, IgG, and IgM. In consideration for the duration of cultures, the 2 week culture was superior to the 4 week culture with respect to graft stemness (CD34+CD38- fraction). Our data suggests most superior results were observed from the ex vivo expansion of CD34+ purified cells cultured for 2 weeks with TPO+FL+SCF+IL-4+IL-10, in the B lymphocyte-mediated immune reconstitution and graft stemness aspect. The results of this study warrant further investigation on effective B lymphocyte-mediated immune reconstitution after cord blood transplantation in vivo using ex vivo expanded cord blood.
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6

Dorward, D. "Interactions Between Mouse Lymphocytes And Borrelia Burgdorferi, The Infectious Agent Of Lyme Disease." Microscopy and Microanalysis 5, S2 (August 1999): 1242–43. http://dx.doi.org/10.1017/s143192760001953x.

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Lyme disease is a tick borne, multi-system disorder caused by low density systemic infections with the spirochete Borrelia burgdorferi. Without antimicrobial treatment, mammalian infections with these bacteria are persistent and chronic. Recent studies showed that B. burgdorferi can target, invade, and lyse both cultured and primary human B and T cells. Direct interactions between the spirochetes and lymphocytes also leads to adherence of B and T cell antigens on the surface of significant proportions of the bacteria . Adherent lymphocytic antigens inhibit binding of antibodies to prominent B. burgdorferi proteins, and interfere with classic complement-mediated killing, suggesting a possible role for spirochete-lymphocyte interactions in immune evasion.In order to develop an experimental animal model for assessing spirochete-lymphocyte interactions, B. burgdorferi and primary mouse lymphocytes were co-incubated and examined by electron microscopy. Mononuclear cells were separated from fresh mouse blood by Ficoll gradient centrifugation (ICN, Biomedicals, Aurora, Ohio).
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7

Matsushima, K., A. Procopio, H. Abe, G. Scala, J. R. Ortaldo, and J. J. Oppenheim. "Production of interleukin 1 activity by normal human peripheral blood B lymphocytes." Journal of Immunology 135, no. 2 (August 1, 1985): 1132–36. http://dx.doi.org/10.4049/jimmunol.135.2.1132.

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Abstract Interleukin 1 (IL 1) production by normal human B lymphocytes was investigated. Normal human peripheral blood B lymphocytes were purified by sequential separation with the use of Ficoll-Hypaque gradient centrifugation, sheep red blood cell rosette formation, Percoll gradients, and treatment with monoclonal antibodies (anti-Leu-M1, B73.1, and T101) and complement. Both purified large B lymphocytes (BL) and small B lymphocytes (BS) produced IL 1-like (thymocyte co-mitogenic and fibroblast mitogenic) activities in response to lipopolysaccharide. Maximal production of IL 1 activity by both BL and BS occurred at 48 hr. The m.w. of IL 1 activities from both BL and BS were about 20,000 with high pressure liquid chromatography, and the major isoelectric point of BL- and BS-derived IL 1 activity was 7.0. A rabbit anti-human monocyte IL 1 antiserum inhibited the activity of B cell-derived IL 1, suggesting antigenic similarities of monocyte- and B lymphocyte-derived IL 1 moieties. These data suggest that normal B lymphocyte-derived IL 1 activity is biochemically and immunologically similar to monocyte-derived IL 1.
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8

van Zelm, Menno C., Tomasz Szczepański, Mirjam van der Burg, and Jacques J. M. van Dongen. "Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion." Journal of Experimental Medicine 204, no. 3 (February 20, 2007): 645–55. http://dx.doi.org/10.1084/jem.20060964.

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The contribution of proliferation to B lymphocyte homeostasis and antigen responses is largely unknown. We quantified the replication history of mouse and human B lymphocyte subsets by calculating the ratio between genomic coding joints and signal joints on kappa-deleting recombination excision circles (KREC) of the IGK-deleting rearrangement. This approach was validated with in vitro proliferation studies. We demonstrate that naive mature B lymphocytes, but not transitional B lymphocytes, undergo in vivo homeostatic proliferation in the absence of somatic mutations in the periphery. T cell–dependent B cell proliferation was substantially higher and showed higher frequencies of somatic hypermutation than T cell–independent responses, fitting with the robustness and high affinity of T cell–dependent antibody responses. More extensive proliferation and somatic hypermutation in antigen-experienced B lymphocytes from human adults compared to children indicated consecutive responses upon additional antigen exposures. Our combined observations unravel the contribution of proliferation to both B lymphocyte homeostasis and antigen-induced B cell expansion. We propose an important role for both processes in humoral immunity. These new insights will support the understanding of peripheral B cell regeneration after hematopoietic stem cell transplantation or B cell–directed antibody therapy, and the identification of defects in homeostatic or antigen-induced B cell proliferation in patients with common variable immunodeficiency or another antibody deficiency.
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9

Dohi, Keiichiro, William J. Kraemer, and Andrea M. Mastro. "Exercise increases prolactin-receptor expression on human lymphocytes." Journal of Applied Physiology 94, no. 2 (February 1, 2003): 518–24. http://dx.doi.org/10.1152/japplphysiol.00004.2002.

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Plasma prolactin has been shown to increase during stress; the immune system is responsive to prolactin and affected by stress. Therefore, this study was undertaken to investigate the effects of acute graded, maximal treadmill exercise on prolactin-receptor expression by lymphocytes. Eight healthy men underwent one exercise and one nonexercise session. Blood was sampled immediately before and after the exercise. On the day of the nonexercise session, two resting blood samples were obtained at the same times as the exercise session samples to act as baseline data. Plasma prolactin concentrations were significantly elevated in response to exercise and correlated positively with total prolactin-receptor expression per B lymphocyte. An increase in total prolactin-receptor expression per B lymphocyte in response to exercise also was observed. In addition, exercise significantly increased the total number of circulating B lymphocytes expressing prolactin receptor as well as the total number of circulating B lymphocytes. These data support the idea that exercise may enhance the interaction between immune target cells and prolactin, a stress hormone capable of enhancing immune function.
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10

Pals, S. T., G. Kraal, E. Horst, A. de Groot, R. J. Scheper, and C. J. Meijer. "Human lymphocyte-high endothelial venule interaction: organ-selective binding of T and B lymphocyte populations to high endothelium." Journal of Immunology 137, no. 3 (August 1, 1986): 760–63. http://dx.doi.org/10.4049/jimmunol.137.3.760.

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Abstract We wished to determine whether human lymphocytes, like their murine counterparts, show organ-specific interactions with high endothelial venules (HEV). Functional HEV-binding ability was measured by an in vitro assay of lymphocyte adherence to HEV in frozen sections of human lymphoid tissues which was adapted from rodent systems. It was found that human lymphocytes bind selectively to HEV and that, whereas mature T lymphocytes bind preferentially to HEV in peripheral lymph nodes and tonsils, B lymphocytes show preferential binding to HEV in GALT. Moreover, by analyzing the binding characteristics of T4+ and T8+ T cell populations, it was found that T8+ cells adhere preferentially to HEV in GALT and mesenteric lymph nodes and tonsil, and that T4+ cells bind slightly better to HEV in peripheral lymph nodes. The above findings indicate that organ--specific lymphocyte-endothelial cell recognition mechanisms exist also in humans, and suggest that these mechanisms play an important role in normal and pathologic lymphocyte traffic.
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Більше джерел

Дисертації з теми "Human B Lymphocyte"

1

Boldra, Denise Carole. "Factors affecting human B lymphocyte stimulation in organ graft recipients." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282735.

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2

Symington, Hannah Lucy. "Mechanism of IL-2 mediated BACH2 regulation in the control of Human naive B cell differentiation into plasma cells." Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1B009.

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La différenciation terminale des lymphocytes B qui se déroule dans les centres germinatifs des organes lymphoïdes secondaires est l’étape ultime de la réponse T dépendante et aboutit à la production de plasmocytes (PC) à longue durée de vie qui sécrètent des anticorps hautement affins spécifiques de l’antigène et caractéristiques de la réponse immune adaptative. La transition d’une cellule B naïve vers un PC est gouvernée par un réseau de régulation génique bien décrit et est largement influencée par l’intégration de stimuli externes qui contrôlent le devenir des cellules B tels que l’interaction BCR-antigène et les cytokines produites par les cellules T. La stimulation précoce des lymphocytes B humains activés par IL-2, induit la différenciation en PC via une signalisation ERK prolongée entraînant la baisse d’expression de BACH2, un facteur de transcription clef des cellules B. La répression transitoire de BACH2 est suffisante pour déclencher la différenciation en plasmablastes en l’absence d’IL-2, suggérant ainsi qu’il joue un rôle de « verrou moléculaire » de la différenciation en PC. Il est à noter que cette répression forcée de BACH2 aboutit à la production de plasmablastes caractérisés par un phénotype lymphoplasmocytaire. Ce travail de recherche s’est focalisé sur la caractérisation des mécanismes moléculaires régulant l’expression de BACH2 via la voie de signalisation ERK induite par IL-2. Nous avons identifié ELK-1 comme un médiateur de la répression de BACH2 par la voie IL-2/ERK, comme l’atteste sa capacité à se lier avec un élément de régulation d’un enhancer localisé dans l’intron 1 de BACH2, induisant ainsi la répression de l’enhancer et déverrouillant la différenciation en PC. La caractérisation de cet enhancer de BACH2 a confirmé qu’il est régulé de manière dynamique au cours de la différenciation terminale B et qu’il est localisé dans une région sujette aux mutations suggérant qu’il pourrait être impliqué dans la lymphomagenèse
The terminal differentiation of B cells, which takes places within germinal centres of secondary lymphoid organs, is the ultimate step of a T cell dependent response and results in the generation of long-lived plasma cells (PCs) that secrete protective, antigen-specific, high-affinity antibodies as part of adaptive immunity. The transition of a naive B cell into a PC is governed by a well-characterised gene regulatory network and is heavily influenced by the integration of externally received signals, including BCR-antigen binding and T cell help, such as cytokines which guide B cell fate. The early IL-2 priming of human primary activated B cells triggers PC differentiation through sustained ERK signalling resulting in the down regulation of B cell transcription factor BACH2. Transient BACH2 repression is sufficient to trigger plasmablast differentiation in the absence of IL-2 suggesting that it acts as a key lock of PC differentiation. Importantly, this enforced BACH2 repression results in the generation of plasmablasts with a lymphoplasmacytic phenotype. The focus of this thesis was to characterise the molecular mechanisms regulating BACH2 expression via the IL-2 ERK transduction pathway. We identify ELK-1 as the mediator of IL-2 ERK induced BACH2 downregulation as it binds to a regulatory enhancer element located within intron 1 of BACH2 instigating its repression and unlocking the PC programme triggering differentiation. The characterisation of this BACH2 enhancer confirms that it is dynamically regulated during PC differentiation and is located within a region targeted for mutation suggesting that it may have a potential role in lymphomagenesis
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3

Liu, Anquan. "Proinflammatory factor mediated lymphocyte activation - the pivotal role of leukotriene B4 /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-391-7/.

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4

MacLellan, Lindsay. "Alpha v beta 5 and related receptors in human B lymphocyte development." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/260/.

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CD23 is a multi-functional protein which exists in membrane-bound and soluble forms. Its functions include acting as the low affinity receptor for IgE and generating pro-inflammatory cytokine release in monocytes. CD23 has been found to interact with αvβ5 and this interaction greatly enhances growth of the B cell precursor cell line SMS-SB. This interaction may have a role in the development of normal human B cells and in cancer as the integrin is expressed on both precursor and ALL cells but not on normal mature B cells. One of the aims of this investigation was to expand on the finding that CD23 peptides containing an RKC motif had the same positive growth effect on SMS-SB cells as CD23. Other B cell lines – representative of both precursor and mature stages – were studied to ascertain whether this proliferative effect was dependent upon cell differentiation stage and/or presence of the αvβ5 integrin. It was found that peptides containing the basic RKC motif were mitogenic only for precursor B cells which were expressing αvβ5. Details of these peptides and their varying effects on the different cell lines are in Chapter 4. Stimulation of SMS-SB cells, presumably via the αvβ5, results in signalling through PI3K and subsequent phosphorylation of Akt. The growth of SMS-SB cells observed following stimulation with peptides containing the RKC motif was abrogated by the PI3K inhibitor LY294002 and western blotting revealed that phosphorylation of Akt was enhanced by stimulation with RKS containing peptides. Among CD23’s receptors is the integrin αvβ3. This integrin can form a signalling complex with CD47. Ligation of CD47 by anti-CD47 antibodies induces apoptosis in some cell lines. To determine whether a pattern exists between response to this stimulation and expression of αvβ3 integrin, cell lines with and without the integrin were tested. It was found that the myeloma cell lines KMS11 and H929 were responsive to this stimulus. Since these cell lines differ in their expression of αvβ3 (H929 cells express αvβ3 whereas KMS11 do not) it does not appear that any connection between the presence of the integrin and response via CD47 exists and therefore this signalling mechanism would appear to occur independently of the complex formed by CD47 and αvβ3.
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5

Liu, Jing. "Regulation of VH replacement in human immature B cells by B cell receptor (BCR)-mediated signaling." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2010p/liu.pdf.

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6

Howard, Donald Raymond. "Cell surface antigens in normal and neoplastic human B lymphocyte differentiation : cellular distribution and functional implications." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25809.

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Differentiation within the lymphoid system produces effector cells which are involved in a variety of immune functions. For T cells these include the provision of help, suppression, cytolytic activity and the regulation of cooperative cellular interactions. The primary function of B lineage cells is the production of specific antibody. Understanding the regulation of normal lymphocyte proliferation and differentiation may lead to a better appreciation of those factors which result in the development of malignancy. The non-Hodgkin's lymphomas are neoplasms of the immune system, the majority of which are B cell in origin. Despite advances in immunology and molecular biology, little is known about the mechanisms involved in B cell activation, proliferation and differentiation or about those events leading to their malignant transformation. The advent of monoclonal antibody technology a decade ago has revolutionized our ability to identify and characterize cell surface antigens. Because the activation and control of proliferation of B cells was already known to involve structures at the cell surface, it was logical to utilize monoclonal antibodies to identify additional cell surface molecules that might be important in the function of normal B lymphocytes and that might allow normal and various types of neoplastic B cells to be distinguished. To achieve this goal, we developed monoclonal antibodies that showed differential reactivity between large actively dividing lymphoma cells and small inactive (quiescent) lymphocytes. These were tested for their ability to inhibit various T and B lymphocyte functions (i.e. responses to anti-µ, lipopolysaccharide, phytohemagglutinin and the mixed lymphocyte response) as well as for their reactivity with cell suspensions from a variety of malignant and nonmalignant hematopoietic tissues. From these studies emerged the following: 1) Cell surface molecules other than Immunoglobulin are involved in regulating the activation of normal B cells. This was shown by the discovery that monoclonal antibodies to both lymphocyte function associated antigen (LFA-1) and certain HLA class II determinants were able to inhibit the activation of peripheral blood mononuclear cells by the B cell mitogens anti-p and LPS. This inhibition was shown to be mediated via effects of these antibodies on T cells and/or monocytes. 2) B lymphoma cells appear to express unique cell surface antigens (defined by monoclonal antibodies LM-26 and LM-155) not detectable on cells of other lineages, and absent from normal resting or activated B lymphocytes. Future investigations will attempt to define the mechanisms by which the indirect involvement of LFA-1 and HLA class II molecules in B cell activation in vitro suggests new regulatory interactions not previously identified. Further studies will be required to define the mechanisms underlying these interactions and their significance in vivo. Similarly, the structure and function of the antigens detected by LM-26 and LM-155 remains to be determined. Nevertheless, the expression of apparently unique molecules on B lymphoma cells holds new promise for the diagnosis, classification and treatment of this group of diseases.
Medicine, Faculty of
Pathology and Laboratory Medicine, Department of
Graduate
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7

Yaciuk, Jane Cherie. "Mechanisms of T cell tolerance to the RNA-binding nuclear autoantigen human La/SS-B." Oklahoma City : [s.n.], 2008.

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8

Dambrun, Dit Tambrun Magalie. "Lymphocytes B et immunoglobulines néonatales dans un contexte d'infection parasitaire congénitale : stratégies méthodologiques de caractérisation Human immunoglobulin heavy gamma chain polymorphisms: molecular confirmation of proteomic assessment." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB118.

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Durant ses premiers mois de vie, le nouveau-né a la particularité d'être protégé par les immunoglobulines (Ig)G de sa mère, qui sont transférées au cours de la grossesse, et sont présentes dans son sérum conjointement aux IgG qu'il néo-synthétise. La distinction dans un sérum de nouveau-né, entre les IgG d'origine maternelle et fœtale, est difficile à mettre en œuvre, mais peut s'avérer très utile pour contribuer à diagnostiquer de façon précoce certaines infections congénitales, notamment dans le cas d'infections parasitaires. À ces fins, notre groupe de travail a mis en place une méthodologie reposant sur la spectrométrie de masse et qui exploite des polymorphismes peptidiques individuels localisés sur les domaines constants CH2 et CH3-CHS de la chaîne lourde des IgG. Nous proposons dans ce travail de valider cette approche par biologie moléculaire. L'amplification et le séquençage spécifiques des domaines constants CH2 et CH3-CHS des 4 sous-classes d'IgG totales ont permis i/de valider l'approche par spectrométrie de masse bottom-up et ii/de mettre en évidence de nouveaux polymorphismes nucléotidiques entraînant ou non un changement en acide aminé. Cette approche exige une purification exclusive des IgG spécifiques de pathogène, qui peut être contournée en utilisant une autre approche, cellulaire, reposant sur les IgG spécifiques sécrétées par les lymphocytes (Ly) B du nouveau-né. Ainsi, les spécificités individuelle et antigénique de l'Ig sont conciliées. Pour ce faire, un autre développement de mon travail a consisté dans l'adaptation de la technique ELISPOT (Enzyme-Linked ImmunoSpot), dans le cadre de la toxoplasmose, causée par le parasite Toxoplasma gondii, et responsable avec la maladie de Chagas de la plupart des cas d'infections congénitales d'origine parasitaire. Les mises au point ont été faites avec des cellules mononucléées d'adultes volontaires séronégatifs et séropositifs pour la toxoplasmose, qui nous ont conduits à faire le choix d'un lysat parasitaire de T. gondii de type I comme candidat antigénique multi-épitopes par rapport à la protéine recombinante spécifique SAG1 (Surface Antigen 1), protéine membranaire représentative du parasite. L'exploration d'autres paramètres est nécessaire pour compléter l'adaptation de l'ELISPOT dans le cadre précis d'une infection parasitaire congénitale. Il s'agit notamment d'évaluer i/la pertinence du test lors d'une infection récente avec T. gondii, en utilisant des LyB d'adultes en séroconversion et/ou de nouveau-nés ayant contracté une toxoplasmose congénitale, et ii/ l'ubiquité du test, en étudiant sa capacité à révéler avec une même efficacité les IgG sécrétées par des LyB d'individus infectés par des souches de toxoplasme circulant dans des zones géographiques différentes. Pour rendre possible cette dernière phase d'adaptation de l'ELISPOT, la mise en place d'études de terrain s'est imposée afin de constituer une bio-banque dans le cadre de suivis de la toxoplasmose chez des femmes enceintes et leurs nouveau-nés à l'accouchement : une première étude a été réalisée pendant 3 mois en 2018 dans la maternité d'un CHU à Cotonou au Bénin ; parallèlement un essai clinique est en cours pour 18 mois depuis juin 2018 dans 3 maternités d'hôpitaux de l'AP-HP en Ile de France. En supplément, une étude séro-épidémiologique rétrospective de la toxoplasmose chez environ 1000 femmes enceintes au sud du Bénin, à partir de plasmas collectés dans un projet mené en 2008-2010 dans notre UMR, permettra de documenter pour la première fois sur un aussi large effectif, la séroprévalence de la toxoplasmose chez des femmes enceintes au Bénin (53%) ainsi que le taux de séroconversion toxoplasmique pendant la grossesse (en cours). En plus des objectifs énoncés, l'ensemble de ces travaux contribue à mieux documenter l'exploration du système immunitaire fœtal
In the first months of life, the newborn is protected from infections by the maternal immunoglobulins (Ig) G, which are transferred during pregnancy, and are present in his serum together with his neo-synthesized IgG.The distinction in neonatal serum between maternal and fetal IgG is difficult to implement, but could be very useful for diagnosing congenital infections early, particularly in the case of parasitic infections. For this purpose, our team has established a methodology based on mass spectrometry that exploits individual peptide polymorphisms located on the CH2 and CH3-CHS domains from the constant IgG heavy chain. In this work, we propose to validate this approach by molecular biology. The specific amplification and sequencing of the CH2 and CH3-CHS constant domains of the 4 total IgG subclasses allowed i/to validate the bottom-up mass spectrometry approach and ii/to highlight new nucleotide polymorphisms causing or not an amino acid change. This approach requires an exclusive purification of pathogen-specific IgG, which can be circumvented using another cell-based approach, based on the specific IgG secreted by the newborn B lymphocytes (Ly). Thus, the individual and antigenic specificities of Ig are reconciled. To do this, another development of my work consisted in the adaptation of the ELISPOT technique (Enzyme-Linked ImmunoSpot), in the context of the toxoplasmosis, caused by Toxoplasma gondii parasite, and responsible with the Chagas disease of the most cases of congenital infections of parasitic origin. Developments were made with mononuclear cells from adult volunteers seronegative and seropositive for toxoplasmosis, which led us to select a parasitic T. gondii type I lysate as multi-epitopes antigenic candidate compared to the specific recombinant protein SAG1 (Surface Antigen 1), a membrane protein representative of the parasite. The investigation of other parameters is necessary to complete the ELISPOT adaptation in the specific context of congenital parasitic infection. These include assessing i/the suitability of the test in the case of a recent infection with T. gondii, using B Ly from seroconverting adults and/or neonates with congenital toxoplasmosis, and ii/the test ubiquity, by studying its ability to reveal with the same efficiency the IgG secreted by B Ly from individuals infected with toxoplasm strains circulating in different geographical areas. To make this last ELISPOT adaptation phase possible, the implementation of field studies was essential in order to constitute a bio-bank resulting from toxoplasmosis follow-ups of pregnant women and their newborns at childbirth: a first study was conducted for 3 months in 2018 in the CHU maternity in Cotonou, Benin; also, a clinical trial has been in progress for 18 months since June 2018 in 3 AP-HP hospitals maternities, in Ile de France. In addition, a retrospective sero-epidemiological study of toxoplasmosis in about 1000 pregnant women in southern Benin, was conducted, using plasma samples collected 2008-2010 in our unit. This will document for the first time toxoplasmosis seroprevalence on a wide effective of pregnant women in Benin (53%) as well as the rate of toxoplasmic seroconversion during pregnancy (ongoing). In addition to the stated objectives, all of this work contributes to better documenting the exploration of the fetal immune system
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9

Nouël, Alexandre. "Étude du lymphocyte B au cours du rejet d'allogreffe rénale." Phd thesis, Université de Bretagne occidentale - Brest, 2013. http://tel.archives-ouvertes.fr/tel-00951978.

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Le rejet d'allogreffe représente un obstacle majeur en transplantation rénale humaine. Le lymphocyte B (LB) joue un rôle lors de cette réaction contre le greffon, mal défini à ce jour. Notre objectif a été de caractériser et identifier son implication dans le rejet humoral chronique (cABMR) et le rejet cellulaire aigu (ACR). Dans une première partie, la caractérisation phénotypique des LB par cytométrie en flux chez ces patients a mis en évidence d'importantes différences dans la distribution des sous-populations de LB uniquement chez les patients cABMR. Chez les patients ACR, dont la distribution des LB n'est pas altérée, l'analyse de coupes de biopsies rénales a permis de mettre en évidence un infiltrat cellulaire constitué de lymphocytes B et T. Dans une seconde partie, l'activité fonctionnelle et régulatrice des LB issus de patients cABMR et ACR a été évaluée à l'aide d'un modèle in vitro de coculture entre des LB et des LT. Cette étude a révélé que les LB, issus des patients cABMR uniquement, sont dépourvus d'activités régulatrices sur la fonction des LT autologues. Cette étude a aussi mis en exergue que les LB des patients cABMR présentaient une déficience dans la sécrétion de molécules immunosuppressives telles que le TGFβ et l'indoleamine 2,3-dioxygénase (IDO). Ce défaut conduit à une incapacité à générer des lymphocytes T régulateurs. Finalement, notre étude a clairement démontré le rôle du LB dans les mécanismes physiopathologiques conduisant au rejet. Ces travaux ont donc permis de générer d'éventuelles perspectives pour définir de nouvelles stratégies thérapeutiques dans la lutte contre le rejet d'allogreffe.
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10

Feldman, Kristyn. "The effect of support cells on B lymphocyte viability in an in vitro human immune system construct." Honors in the Major Thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1164.

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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.
Bachelors
Burnett School of Biomedical Sciences
Molecular Biology & Microbiology
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Книги з теми "Human B Lymphocyte"

1

Graham, Bird Angus, and Calvert Jane E, eds. B lymphocytes in human disease. Oxford: Oxford University Press, 1988.

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2

Finney, Michael. A study in the molecular basis of human B lymphocyte activation. Birmingham: University of Birmingham, 1991.

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3

1952-, Zouali Moncef, ed. Human B-cell superantigens. Austin: Landes, 1996.

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4

Ghaderi, Abbas Ali. Functional study of the low affinity IgE receptor (Fc[epsilon]RII/CD23) on human B lymphocytes. Birmingham: University of Birmingham, 1990.

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5

Gillis, L. Jane. Expression and recombinase activity of RAG 1 and two splice variants of RAG 2 in mature human primary tonsilar B lymphocytes. Ottawa: National Library of Canada, 1999.

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6

McGinnes, Kimberley Gay *. Analysis of human B-lymphocyte development. 1991.

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7

Rie, Menno Alexander de. Studies on in-vitro activation of human B cells. 1988.

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8

Rie, Menno Alexander de. Studies on in-vitro activation of human B cells. 1988.

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9

Talbott, Mary Catherine. The effect of vitamin B-6 supplementation on lymphocyte responsiveness in independently-living elderly persons. 1986.

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10

Talbott, Mary Catherine. The effect of vitamin B-6 supplementation on lymphocyte responsiveness in independently-living elderly persons. 1986.

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Частини книг з теми "Human B Lymphocyte"

1

Burrows, Peter D., Hiromi Kubagawa, Norihiro Nishimoto, William G. Kerr, Gary V. Borzillo, Linda M. Hendershot, and Max D. Cooper. "Differences in Human B Cell Differentiation." In Mechanisms of Lymphocyte Activation and Immune Regulation III, 215–26. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-5943-2_24.

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2

Kishimoto, Tadamitsu, Toshio Hirano, Hitoshi Kikutani, and Atsushi Muraguchi. "Delineation of Human B Cell Differentiation: Immunological and Molecular Characterization of Human B Cell Differentiation Factor (BSF-2)." In Mechanisms of Lymphocyte Activation and Immune Regulation, 177–88. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5323-2_17.

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3

Ambrus, Julian L., Cynthia H. Jurgensen, Debra L. Bowen, Shohken Tomita, Toshimasa Nakagawa, Naoko Nakagawa, Harris Goldstein, Normal L. Witzel, Howard S. Mostowski, and Anthony S. Fauci. "The Activation, Proliferation, and Differentiation of Human B Lymphocytes." In Mechanisms of Lymphocyte Activation and Immune Regulation, 163–75. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5323-2_16.

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Sutro, Jeffrey B., Bharathi S. Vayuvegula, Sudhir Gupta, and Michael D. Cahalan. "Voltage-Sensitive Ion Channels in Human B Lymphocytes." In Mechanisms of Lymphocyte Activation and Immune Regulation II, 113–22. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4757-5803-0_14.

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Vayuvegula, Bharathi, Sastry Gollapudi, and Sudhir Gupta. "Inhibition of Human B Cell Proliferation By Ion Channel Blockers." In Mechanisms of Lymphocyte Activation and Immune Regulation, 237–40. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5323-2_23.

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Blazar, B. A., P. Sereno, L. Stevenson, and A. M. Murphy. "Helper T Lymphocyte Proliferation is Stimulated by the Presence of EBV-Carrying B Lymphocytes." In Epstein-Barr Virus and Human Disease • 1988, 189–93. Totowa, NJ: Humana Press, 1989. http://dx.doi.org/10.1007/978-1-4612-4508-7_27.

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Kehrl, John H., and Anthony S. Fauci. "Alternative Cytokines in the Immunoregulation of the Human B Cell Cycle." In Mechanisms of Lymphocyte Activation and Immune Regulation II, 145–54. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4757-5803-0_17.

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Scala, G., F. Ferrara, T. Pastore, F. Alfinito, R. Pizzano, L. Corbo, and S. Venuta. "Autocrine Growth Function of Interleukin-1-Like Molecules Secreted by Neoplastic Human B Cells." In Mechanisms of Lymphocyte Activation and Immune Regulation, 115–24. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5323-2_11.

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Siliciano, R. F. "Molecular Aspects of Human B and T Lymphocyte Responses to HIV." In Herpesviruses, the Immune System, and AIDS, 45–71. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-1507-0_3.

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Kishimoto, Tadamitsu, Tetsuya Taga, Katsuhiko Yamasaki, Tadashi Matsuda, Bo Tang, Atsushi Muraguchi, Yasuhiro Horii, et al. "Normal and Abnormal Regulation of Human B Cell Differentiation by a New Cytokine, BSF2/IL-6." In Mechanisms of Lymphocyte Activation and Immune Regulation II, 135–43. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4757-5803-0_16.

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Тези доповідей конференцій з теми "Human B Lymphocyte"

1

Filippi, J. F., D. Arnoux, N. Tubiana, B. Boutière, F. Le Caär, J. Sampol, Lab Hématol, Pr J. Sampol, and Pr Y. Carcassonne. "PLASMINOGEN ACTIVATOR ACTIVITY OF NORMAL AND MALIGNANT MONONUCLEAR HUMAN CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643167.

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Plasminogen activators (PA) are thought to play a role in the invasive and metastatic properties of many types of cancer cells. Though, discrepancies in correlations between fibrinolytic activity and metastatic potential of malignant cells have been described.In this study, we evaluated both tissue type (tPA) and urokinase type (UK) cellular PA activities in different mononuclear cell types : normal T and B human peripheral lymphocytes, B cells from patients with chronic lymphocytic leukemia (CLL), human blood monocytes, alveolar macrophages, U 937, RAJI and JM cell 1ines.Mononuclear cells were isolated by Ficoll-hypaque gradients and monocytes by plastic adhesion. T and B cells were separated by a rosetting technique using sheep red blood cells. Cellular extracts were prepared by 0.5 % Triton X 100 buffer treatment followed by sonication and centrifugation 10 ' at 2000 g. PA assays were performed on the supernatants.UK-type PA was evaluated by a liquid-phase assay in presence of human plasminogen (Kabi) and chromogenic substrate S 2251 (Kabi).tPA was determinated using a solid-phase fibrin activity assay which involves an affinity separation step and thus allows selective detection of tPA.In both cases, results were reported in international units by reference to standard curves of UK (Choay) or tPA (Kabi).In all cell types tested, PA detected was essentially urokinase-type. Highest PA activity was found in U 937 cells (0.7 IU/5×l06 cells). In normal blood lymphocytes, mean PA activity was 0.08 IU/5×l06 cells. Examination of lymphocytes from patients with CLL revealed a marked decrease in UK activity as compared to normals (< 0.01 IU/5×106 cells in more than 50 % cases).The function of PA in normal lymphocyte physiology and the potential pathogenic role of diminished PA in CLL lymphocytes remains to be investigated.
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2

Aydar, S., S. Alataş, L. Numanoğlu, and A. Sönmezdağ. "EFFECT OF ORAL ANTICOAGULANTS ON STABLE ROSETTE FORMATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643271.

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Human peripheral blood T lymphacytes when cultered in the presence of mitogen Phytohemogglutinin (PHA) acquire the capacity to form E rosettes with sheep erythrocytes that are resistant to incubation at 37° C. Whereas human thymus lymphocytes form 37° C stable E rosettes. On the other hand, it is shown that the use of anticoagulants can prevent cancer metastases which brings forth the importance of explaining the relationship between the lymphocyte functions and anticoagulant action mecha-nismus. In order to investigate this relationship, we did a group af experiments with lymphocytes of normal children and of children with severe burn wounds. Peripheral blood lymphocytes were seperated by “Lymphoprep” centrifugation technique. The lymphocytes of normal children and patients with burn were divided in two groups: A-Activated lymphocytes: 1×106 /ml lymphocytes were cultured and activated by PHAfor 48 hours at 37° C in RPMI 1640. B-Non activated lymphocytes were in culture witout PHA. 1×10™6 M/ml warfarin sulfate was added to some of the cultures of each group prior to the culture conditions. At the end of the 48 hour incubation, heat stable rosette formation was determined by the method of Wauve and co-workers. Significantly elevated levels of heat stable rosette forming cells were found in the PHA activated culture treated with warfarin sulfate in normals and patients with burn. Although the blastic transformation of T lymphocytes was found to be depressed, heat stable rosette formation of warfarin sulfate treated lymphocytes abtained from burn patients was observed to be significantly elevated. It is concluded that warfarin sulfate increases the activity of T lymphocytes by interfering with the resynthesis of heai stable E receptors.
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Liang, Xiaoyan, Xianzhu Wu, Jeevitha Jeevan, Samuel Butler, Pranav Murthy, Arthur Sands, and Michael Lotze. "254 The CBL-B inhibitor, NX-0255, enhances human drug enhanced tumor infiltrating lymphocyte (DeTIL) expansion and T cell function in full-scale runs." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.0254.

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4

Tokumaru, Kumon. "The Three Stage Digital Evolution of Linguistic Humans." In GLOCAL Conference on Asian Linguistic Anthropology 2019. The GLOCAL Unit, SOAS University of London, 2019. http://dx.doi.org/10.47298/cala2019.12-2.

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Digital Linguistics (DL) is an interdisciplinary study that identifies human language as a digital evolution of mammal analog vocal sign communications, founded on the vertebrate spinal sign reflex mechanism [Tokumaru 2017 a/b, 2018 a/b/c/d]. Analog signs are unique with their physical sound waveforms but limited in number, whilst human digital word signs are infinite by permutation of their logical property, phonemes. The first digital evolution took place 66,000 years ago with South African Neolithic industries, Howiesons Poort, when linguistic humans acquired a hypertrophied mandibular bone to house a descended larynx for vowel accented syllables containing logical properties of phonemes and morae. Morae made each syllable distinctive in the time axis and enabled grammatical modulation by alternately transmitting conceptual and grammatical syllables. The sign reflex mechanism is an unconscious self-protection and life-support mechanism, operated by immune cell networks inside the ventricle system. DL identified cellular and molecular structures for the sign (=concept) device as a B lymphocyte (or, in other words, Mobile Ad-Hoc Networking Neuron), connects to sensory, conceptual and networking memories, which consist of its meanings [Table 1]. Its antibodies can network with antigens of CSF-Contacting Neurons at the brainstem reticular formation and of Microglia cells at the neocortex [Figure 1]. It is plausible that the 3D structure of the antigen molecule takes the shape of word sound waveform multiplexing intensity and pitch, and that specifically pairing the antibody molecule consists of three CDRs (Complementality Defining Regions) in the Antibody Variable Region network with the logic of dichotomy and dualism. As sign reflex deals with survival issues such as food, safety and reproduction, it is stubborn, passive and inflexible: It does not spontaneously look for something new, and it is not designed to revise itself. These characteristics are not desirable for the development of human intelligence, and thus are to be overcome. All the word, sensory and network memories in the brain must be acquired postnatally through individual learning and thought. The reason and intelligence of humans depend on how correctly and efficiently humans learn new words and acquire appropriate meanings for them.
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Giubileo, Gianfranco, Agostina Congiu Castellano, Silvia Gaudenzi, Paola Grimaldi, Deleana Pozzi, and Adriana Puiu. "UV-B radiation induced effects on human T-lymphocytes." In SPIE Proceedings, edited by Valentin I. Vlad. SPIE, 2007. http://dx.doi.org/10.1117/12.757866.

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Carmona, Eva M., Theodore Kottom, Deanne Hebrink, and Andrew H. Limper. "CD4-Independent Activation Of Human B Lymphocytes By Pneumocystis Beta-Glucans." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3298.

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Holzer, Astrid, Kathrin Watzinger, and Christian M. Kähler. "Activation of the NOTCH signaling pathway stimulates migration of human B-lymphocytes." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa389.

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Furihata, Kenichi, Diane J. Nugent, Amy L. Bissonette, Elizabeth Vokac, and Thomas J. Kunicki. "PRODUCTION OF HUMAN MONOCLONAL ANTIBODIESSPECIFIC FOR PLATELET MEMBRANE GLYCOPROTEIN IIIa." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643705.

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Human monoclonal antibodies specific for platelet membrane glycoproteins (GPs) arepotentially important reagentsfor studies of the immunogenicity of membrane glycoproteins. A human monoclonalautoantibody, 5E5, reactive with plateletGPIIIa has been developed (Nugent, et al.,Blood, 1987, in press). In this report, we describe the production of additional human monoclonal antibodies specific for GPIIIa. Peripheral blood lymphocytes fromone patient with post-transfusion purpur(PTP) and one woman who had delivered an infant with neonatal alloimmune thrombocytopenic purpura (NATP) were used as a source of antigen-specific lymphocytes. A B-lympho-cyte-enriched population was transformed with Epstein Barr virus, strain B95-8, and cultured in microtiter plates. After two weeks, culture supernatants were screened by an antigen-capture ELISA wherein murine monoclonal antibody specificfor the GPIIb-IIIa complex was used to holdcorresponding antigen from a lysate ofnormal platelets. B-lymphoblastoid cell lines producing IgG and/or IgM antibodies were expanded and either cloned by limiting dilution technqiue or hybridized with a HAT-sensitive, ouabain-resistant heterohybrid fusion line, F6, using polyethylene glycol. Hybridomas were selected in medium containing HAT andouabain. After twoweeks, hybridomas producing anti-GPIIb and/or anti-GPIIIa antibody were cloned by limiting dilution. Culture supernatants from cloned B-lymphoblastoid cell lines and cloned hybridomas were rescreened by ELISA wherein affinity-purified GPIIIa or other platelet GP weredirectly conjugatedto microtiter plates. One IgM antibody produced by acloned B-lymphoblastoid cellline (CH16) andtwo IgG antibodies produced bycloned hybridomas(Del5.19 and Del5.23) were shownto react with GPIIIa but not other GP. Further characterization of these human monoclonal antibodies, produced continuouslyin culture now for four months, is in progress.
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Gandolfo, S., M. Bulfoni, C. Fabro, E. Doriguzzi Breatta, L. Quartuccio, C. Di Loreto, D. Cesselli, and S. De Vita. "FRI0288 Thymic stromal lymphopoietin (TSLP) biological effects on human peripheral blood b lymphocytes in primary sjÖgren’s syndrome." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.6265.

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Yuguo, Song, Xiang Lei, and Bi Shengli. "Analysis of T cell receptor V beta diversity in peripheral CD8(+) T lymphocytes in patients with hepatitis B infection." In 2011 International Conference on Human Health and Biomedical Engineering (HHBE). IEEE, 2011. http://dx.doi.org/10.1109/hhbe.2011.6027968.

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Також вас можуть зацікавити розширені добірки на тему "Human B Lymphocyte" для конкретних типів джерел:
Статті в журналах Дисертації Книги
Ми пропонуємо знижки на всі преміум-плани для авторів, чиї праці увійшли до тематичних добірок літератури. Зв'яжіться з нами, щоб отримати унікальний промокод!

До бібліографії