Готові списки джерел за темами / HITS

Добірка наукової літератури з теми "HITS"

Автор: Grafiati
Опубліковано: 4 червня 2021
Оновлено: 27 квітня 2022

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Статті в журналах з теми "HITS"

1

Khan, Abbas, Omar Ahsan, Dong-Qing Wei, Jawad Khaliq Ansari, Muzammil Hasan Najmi, Khalid Muhammad, and Yasir Waheed. "Computational Evaluation of Abrogation of HBx-Bcl-xL Complex with High-Affinity Carbon Nanotubes (Fullerene) to Halt the Hepatitis B Virus Replication." Molecules 26, no. 21 (October 25, 2021): 6433. http://dx.doi.org/10.3390/molecules26216433.

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Hepatitis B virus (HBV) is the world’s most prevalent chronic viral infection. More than 350 million individuals are chronic carriers of the virus, with an estimated 2 billion infected persons. For instance, the role of HBx protein in attachment and infection is very obvious and consequently deemed as an important druggable target. Targeting the interface and discovering novel drugs greatly advanced the field of therapeutics development. Therefore, in the current study, HBx to Bcl-xL is abrogated on high-affinity carbon nanotubes using computational structural biology tools. Our analysis revealed that among the total 62 carbon fullerenes, only 13 compounds exhibited inhibitory activity against HBx, which was further confirmed through IFD-based rescoring. Structural dynamics investigation revealed stable binding, compactness, and hydrogen bonds reprogramming. Moreover, the binding free energy calculation results revealed that the top hits1-4 possess the total binding energy of −54.36 kcal/mol (hit1), −50.81 kcal/mol (hit2), −47.09 kcal/mol (hit3), and −45.59 kcal/mol for hit4. In addition, the predicted KD values and bioactivity scores further validated the inhibitory potential of these top hits. The identified compounds need further in vitro and in vivo validation to aid the treatment process of HBV.
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2

Franceschet, Massimo. "HITS hits art." Blockchain: Research and Applications 2, no. 4 (December 2021): 100038. http://dx.doi.org/10.1016/j.bcra.2021.100038.

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3

Melton, Heather C., and Joanne Belknap. "He Hits, She Hits." Criminal Justice and Behavior 30, no. 3 (June 2003): 328–48. http://dx.doi.org/10.1177/0093854803030003004.

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4

Neame, Elizabeth. "HITS-CLIP hits the microRNA target." Nature Reviews Genetics 10, no. 8 (August 2009): 510–11. http://dx.doi.org/10.1038/nrg2635.

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5

Lawton, Graham. "Climate Hits." New Scientist 241, no. 3218 (February 2019): 40–43. http://dx.doi.org/10.1016/s0262-4079(19)30334-3.

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6

Mole. "Greatest hits." Journal of Cell Science 119, no. 5 (March 1, 2006): 783–85. http://dx.doi.org/10.1242/jcs.02863.

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7

Lewis, Tanya. "Quick Hits." Scientific American 319, no. 1 (June 19, 2018): 21. http://dx.doi.org/10.1038/scientificamerican0718-21.

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Wojtys, Edward M. "Big Hits." Sports Health: A Multidisciplinary Approach 1, no. 6 (November 2009): 459–60. http://dx.doi.org/10.1177/1941738109350412.

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Marks, Andrea. "Quick Hits." Scientific American 316, no. 5 (April 18, 2017): 20. http://dx.doi.org/10.1038/scientificamerican0517-20.

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Saplakoglu, Yasemin. "Quick Hits." Scientific American 318, no. 5 (April 17, 2018): 19. http://dx.doi.org/10.1038/scientificamerican0518-19.

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Дисертації з теми "HITS"

1

Azhari, Ala A. "Identification of Novel Hits Against." Scholar Commons, 2018. http://scholarcommons.usf.edu/etd/7123.

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Leishmaniasis is a disease caused by obligate intracellular parasites of the genus Leishmania, including 20 species that are pathogenic to humans. Female sand fly is the known vector that can transmit the disease. Visceral leishmaniasis is the severe form of the disease that affects internal organs and can be fatal with inappropriate diagnosis or treatment. Leishmania donovani is the causative agent of visceral leishmaniasis. Approximately 350 million in 89 countries are at risk of infection. Around 2 million new cases are reported annually with 500,000 of these are visceral leishmaniasis. Current drug therapies are inadequate due to their toxicity, high cost, severe adverse reaction, limited availability, and the emergence of resistance. With all these limitations, the need for new drugs is urgent. Pentavalent antimonials are the first line of treatment for leishmaniasis since the 1940s. Although amphotericin B, pentamidine and paromomycin are current drugs that treat leishmaniasis, they were discovered initially as a treatment for other pathogens. Furthermore, miltefosine the only available oral drug for leishmaniasis is an anticancer drug that found to be active against Leishmania. Therefore, we used our quantitative Leishmania donovani axenic amastigote assay and the clinically relevant infected macrophage assay to identify new antileishmanial hits from unstudied or understudied natural product sources such as mangrove endophytic fungi, Antarctic deep-sea coral, and terrestrial plants. We also used the same assays to screen synthetic compounds form multiple chemical scaffolds. Our well-established assays led to the identification of new antileishmanial hits from unstudied natural products and the discovery of new classes of molecules from synthetic compounds that possess potent activity against Leishmania donovani. Finally, we conducted an in vivo hamster study on an active hit that revealed high efficacy against Leishmania donovani in this severe model leading to promising antileishmanial drug development.
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2

Ndoro, Tariro. "The smell hits you first." Thesis, Rhodes University, 2016. http://hdl.handle.net/10962/d1021236.

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This collection of poems and prose poems is a record of my life, from growing up in the small town of Bindura in Zimbabwe to landing in the small town of Grahamstown in South Africa. It is a story of dislocation: physical, emotional, and political. It is a story about borders and boundaries; although not rich, I was raised among the rich; although not white, I spent a considerable part of my childhood in white spaces. These fragments are told through the voice of my younger self and also retrospectively by my adult self. Two important influences on my style and my struggle to write about my identity have been Woman Hollering Creek by Latino American author Sandra Cisneros and Citizen: An American Lyric by US poet Claudia Rankine.
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3

Jones, Sebastian. "Reflections on when the sun hits." Honors in the Major Thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/855.

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When the Sun Hits is a feature length film concerned with the delicate relationship between the individual and the whole. A young man named John has fallen into a state of social paralysis since his father's death. He no longer knows how to relate to others and the world around him. Rather than looking to friends and family for support he closes himself off. After the mysterious disappearance of his mother, John blames himself for her leaving. He tries his best to reconnect with his old life, but finds himself making the same mistakes over and over. When his friend Tracy reaches out to him, he bitterly rejects her and once again finds himself alone. It is then that John puts his old life behind him and sets off to make amends with his mother. John has no idea where his mother might be or if she will accept him. Nonetheless, he reaches into the abyss to see if someone is there, waiting for him. The structure of the film is nonlinear as it deviates from traditional narrative form. The intent of this thesis is to serve as a post-film reflection that discusses the relation between my views on cinema and the film I made. The paper will shift between the general themes of the narrative and the film theory working behind it all. It will explore the idea of cinema as an extension of the mind and how this is present in the film. By using specific examples from the film this theory of cinema can be fleshed out and an insight into my process may be gleaned.
B.A.
Bachelors
Arts and Humanities
Film
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4

Nassberg, Michael J. "Alouicious Asparagus hits it big [novel] /." Diss., Online access via UMI:, 2007.

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5

Flogvall, Carl, and Stefan Nordenskjöld. "A regression analysis of NHL cap hits." Thesis, KTH, Matematik (Inst.), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-155194.

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This report is a study if a multi linear regression could be used to predict the cap hit of hockey forwards from the NHL. Data was collected during the 2010-2011, 2011-2012, and 2012-2013 seasons. The chosen variables were common hockey statistics and a few none hockey-related, like origin and age. The initial model was improved by removing insignicant covariates, detected by BIC-test and p-values. The final model consisted of 291 players and had an adjusted R2-value of 0,7820. Of the covariates, goals, assists and ice time had the biggest impact on a player's cap hit.
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6

Mattingly, Marybeth Jordan. "After he hits her-- consequences of intimate partner violence." College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/3132.

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Thesis (Ph. D.)--University of Maryland, College Park, 2005.
Thesis research directed by: Sociology. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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7

Lin, Hsuan-Chun. "Development and Application of High Throughput Methods for Interrogating RNA Binding Specificity." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1481206951509556.

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Yovaniniz, Letelier María Constanza. "Searching for RR Lyrae in distant galactic fields using UltraVISTA and SUDDS." Tesis, Universidad de Chile, 2018. http://repositorio.uchile.cl/handle/2250/168685.

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Tesis para optar al grado de Magíster en Ciencias, Mención Astronomía
Buscamos estrellas tipo RR Lyrae en zonas distantes del halo de la Vía Láctea utilizando datos ya existentes: UltraVISTA, una campaña con observaciones en el infrarojo cercano diseñada para obtener imágenes profundas del campo COSMOS, y SUDSS, una extensión del Dark Energy Survey (DES) que añade observaciones en los extremos del tiempo de obser- vación de DES en varios filtros, con la finalidad de observar las curvas de luz de supernovas a alto redshift. Los resultados de la búsqueda de RR Lyrae con estos datos fueron nulos. Ante estos resultados realizamos observaciones simuladas de RR Lyrae, bajo las mismas condi- ciones de los datos observados, demostrando que la cadencia utilizada en las observaciones no permite la identificación del período de las estrellas RR Lyrae. Finalmente probamos el método desarrollado con datos de HiTS (High Cadence Tran- sient Survey), una campaña dedicada a detectar transientes en el óptico, principalmente las primeras horas de las explosiones de supernovas. Luego de responder favorablemente a las observaciones simuladas, logramos identificar en los datos de HiTS 2015A un total de 106 RR Lyrae 7 de las cuales se encuentran a una distancia mayor a 100 kpc.
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Ali, Arslan Mehmet. "Generation and Bioinformatic Analysis of Synthetic Ago HITS-CLIP Data." Thesis, Uppsala universitet, Institutionen för informationsteknologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-204891.

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Micro-RNAs (miRNAs) have been discovered to regulate messenger RNA (mRNA) translation and degradation. Various recent studies have been focused on miRNA target prediction, in order to get a better understanding of the rules and nature of miRNA regulation over mRNAs. In this project we aim to create a software module to identify miRNA target sites on mRNAs. As basis to this project, we refer to a study that identified a platform for miRNA-mRNA interaction in protein-RNA complexes in mouse brain (AGO HITS-CLIP study). We propose a probabilistic model of the data from this study, and generate synthetic sample data according to this model, in order to create a test bed for a discovery module. Our discovery module analyzes the sample data to identify peak regions where the interaction density is high. We present results both on synthetic sample data and data from the AGO HITS-CLIP study to evaluate our module.
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10

Gulliver, Morgan (Morgan E. ). "Effectiveness of grips at minimizing vibrations during field hockey hits." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/105707.

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Анотація:
Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2016.
Cataloged from PDF version of thesis.
Includes bibliographical references (page 30).
An experiment was carried out in order to determine the frequencies experienced in two locations on the stick during two different field hockey hits, the push and the strike. The results from these experiments showed that the top hand during a hit experiences a higher resonant frequency. During the push the top hand experienced an average resonant frequency of 349.1 Hz, compared to the lower hand which experienced an average resonant frequency of 43.95 Hz. During the strike the top hand experienced an average resonant frequency of 197.8 Hz, compared to the lower hand which experienced an average resonant frequency of 24.41 Hz. A second experiment was carried out in order to determine how effective the grip was at dissipating frequencies. The results determined that the grip is most effective over the frequencies of 117 Hz-470 Hz. Both an old and new grip were tested. The new grip was slightly more effective over the frequencies of 117 Hz - 235 Hz, and similar over the frequencies 250 Hz - 470 Hz. From these experiments it was concluded that field hockey grips are most needed and effective on the shaft of the field hockey stick.
by Morgan Gulliver.
S.B.
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Книги з теми "HITS"

1

Etxeburua, Arantza. Hitz hits, paperezko mihisetan lits. Donostia: Kutxa, 1991.

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group), Mike +. the Mechanics (Musical. Hits. [New York, N.Y.]: Atlantic, 2005.

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3

KAUDWAL, Anuradha. Hits. New Delhi: Super Cassettes, 1988.

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4

Ginuwine. Greatest hits. New York, NY: Sony Urban Music/Epic, 2006.

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5

Jackson, Alan. Greatest hits. New York, NY: Arista Nashville, 2003.

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6

Mourelle, Daniel Rubén. Greatest hits. [Buenos Aires]: Libros de Tierra Firme, 1992.

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7

Strait, George. Greatest hits. Universal City, Calif: MCA Records, 1985.

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8

Green, Al. Greatest hits. [West Memphis, AR]: Hi Records, 2009.

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9

Band, Steve Miller. Ultimate hits. Place of publication not identified]: Capitol, 2017.

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Stewart, Rod. Greatest hits. [Burbank, Calif.]: Warner Bros., 1985.

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Частини книг з теми "HITS"

1

Casti, John L. "Why Hits Happen." In Mood Matters, 65–99. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-04835-7_3.

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Marians, Kenneth J. "Replication Hits 50." In The Bacterial Chromosome, 167–76. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555817640.ch8.

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Inhaber, Herbert. "Hits on MRS." In New Risks: Issues and Management, 451–58. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4899-0759-2_50.

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Zanders, Edward D. "Screening for Hits." In The Science and Business of Drug Discovery, 187–97. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-57814-5_9.

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Zanders, Edward D. "Screening for Hits." In The Science and Business of Drug Discovery, 179–89. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9902-3_9.

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Kois, Dan. "Hits." In Israel Kamakawiwo'ole's Facing Future, 132–44. Bloomsbury Publishing Plc, 2009. http://dx.doi.org/10.5040/9781501396946.ch-008.

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"3. Parameter-Auswertungen erfolgreicher Songs." In Warum Hits Hits werden, 157–270. transcript-Verlag, 2014. http://dx.doi.org/10.14361/transcript.9783839427231.157.

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"4. Eigene Experimente und Untersuchungen." In Warum Hits Hits werden, 271–316. transcript-Verlag, 2014. http://dx.doi.org/10.14361/transcript.9783839427231.271.

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"5. Fazit und Diskussion." In Warum Hits Hits werden, 317–66. transcript-Verlag, 2014. http://dx.doi.org/10.14361/transcript.9783839427231.317.

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"2. Kategorien und Parameter der Analyse." In Warum Hits Hits werden, 69–156. transcript-Verlag, 2014. http://dx.doi.org/10.14361/transcript.9783839427231.69.

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Тези доповідей конференцій з теми "HITS"

1

Mizzaro, Stefano, and Stephen Robertson. "Hits hits TREC." In the 30th annual international ACM SIGIR conference. New York, New York, USA: ACM Press, 2007. http://dx.doi.org/10.1145/1277741.1277824.

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Agrawal, Manindra, Chandan Saha, Ramprasad Saptharishi, and Nitin Saxena. "Jacobian hits circuits." In the 44th symposium. New York, New York, USA: ACM Press, 2012. http://dx.doi.org/10.1145/2213977.2214033.

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Keesing, Aaron, Matthew Ooi, Ocean Wu, Xinghao Ye, Lindsay Shaw, and Burkhard C. Wünsche. "HIIT With Hits." In ACSW 2019: Australasian Computer Science Week 2019. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3290688.3290740.

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Demeester, Thomas, Dolf Trieschnigg, Dong Nguyen, Djoerd Hiemstra, and Ke Zhou. "FedWeb Greatest Hits." In WWW '15: 24th International World Wide Web Conference. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2740908.2742755.

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Corsaro, Sandro, and Clifford Parrott. "Flash finally hits Hollywood." In ACM SIGGRAPH 2004 Web graphics. New York, New York, USA: ACM Press, 2004. http://dx.doi.org/10.1145/1186194.1186221.

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Celma, Òscar, and Pedro Cano. "From hits to niches?" In the 2nd KDD Workshop. New York, New York, USA: ACM Press, 2008. http://dx.doi.org/10.1145/1722149.1722154.

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Rohde, Ulrich L., and Ajay K. Poddar. "Phase Hits Insensitive CSRO." In APCCAS 2006 - 2006 IEEE Asia Pacific Conference on Circuits and Systems. IEEE, 2006. http://dx.doi.org/10.1109/apccas.2006.342432.

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Najork, Marc A., Hugo Zaragoza, and Michael J. Taylor. "Hits on the web." In the 30th annual international ACM SIGIR conference. New York, New York, USA: ACM Press, 2007. http://dx.doi.org/10.1145/1277741.1277823.

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Jannach, Dietmar, Lukas Lerche, and Iman Kamehkhosh. "Beyond "Hitting the Hits"." In RecSys '15: Ninth ACM Conference on Recommender Systems. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2792838.2800182.

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Atre, Nirav, Justine Sherry, Weina Wang, and Daniel S. Berger. "Caching with Delayed Hits." In SIGCOMM '20: Annual conference of the ACM Special Interest Group on Data Communication on the applications, technologies, architectures, and protocols for computer communication. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3387514.3405883.

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Звіти організацій з теми "HITS"

1

Atwood, C. L. Hits per trial: Basic analysis of binomial data. Office of Scientific and Technical Information (OSTI), September 1994. http://dx.doi.org/10.2172/10191270.

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Hunt, Jennifer. How Corruption Hits People When They Are Down. Cambridge, MA: National Bureau of Economic Research, August 2006. http://dx.doi.org/10.3386/w12490.

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Quigg, Chris. Fermilab's Greatest Hits: Highlights from the First Fifty Years. Office of Scientific and Technical Information (OSTI), January 2018. http://dx.doi.org/10.2172/1460415.

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Johnson, Kenneth. New Data Show U.S. Birth Rate Hits Record Low. University of New Hampshire Libraries, 2017. http://dx.doi.org/10.34051/p/2020.299.

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Quigg, Chris. Fermilab's Greatest Hits: Scientific Highlights of the First Fifty Years. Office of Scientific and Technical Information (OSTI), August 2017. http://dx.doi.org/10.2172/1460791.

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Johnson, Kenneth. U.S. Fertility Rate Hits Record Low and Births Continue to Diminish. University of New Hampshire Libraries, 2019. http://dx.doi.org/10.34051/p/2020.359.

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Bunn, Fred L., and Sue B. Hinman. Target: A Model for Determining Hits on an Irregularly Shaped Target. Fort Belvoir, VA: Defense Technical Information Center, February 1985. http://dx.doi.org/10.21236/ada153049.

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Mercer, R. R. Morphometry for alpha particle hits of critical targets in the lungs. Final technical report. Office of Scientific and Technical Information (OSTI), November 1998. http://dx.doi.org/10.2172/666239.

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Mussa, R. Estimate of the trigger inefficiency due to extra hits in H1 and H2, using clean Chi(2) events. Office of Scientific and Technical Information (OSTI), July 1992. http://dx.doi.org/10.2172/875503.

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Smith, Kristin. Wives as breadwinners: wives' share of family earnings hits historic high during the second year of the great recession. University of New Hampshire Libraries, 2010. http://dx.doi.org/10.34051/p/2020.121.

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