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Добірка наукової літератури з теми "Hcinap"

Автор: Grafiati

Опубліковано: 23 вересня 2022

Оновлено: 28 січня 2023

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Статті в журналах з теми "Hcinap"

Ke, Yanguo, Farhat Abbas, Yiwei Zhou, Rangcai Yu, Yuechong Yue, Xinyue Li, Yunyi Yu, and Yanping Fan. "Genome-Wide Analysis and Characterization of the Aux/IAA Family Genes Related to Floral Scent Formation in Hedychium coronarium." International Journal of Molecular Sciences 20, no. 13 (July 1, 2019): 3235. http://dx.doi.org/10.3390/ijms20133235.

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Auxin plays a key role in different plant growth and development processes, including flower opening and development. The perception and signaling of auxin depend on the cooperative action of various components, among which auxin/indole-3-acetic acid (Aux/IAA) proteins play an imperative role. In a recent study, the entire Aux/IAA gene family was identified and comprehensively analyzed in Hedychium coronarium, a scented species used as an ornamental plant for cut flowers. Phylogenetic analysis showed that the Aux/IAA gene family in H. coronarium is slightly contracted compared to Arabidopsis, with low levels of non-canonical proteins. Sequence analysis of promoters showed numerous cis-regulatory elements related to various phytohormones. HcIAA genes showed distinct expression patterns in different tissues and flower developmental stages, and some HcIAA genes showed significant responses to auxin and ethylene, indicating that Aux/IAAs may play an important role in linking hormone signaling pathways. Based on the expression profiles, HcIAA2, HcIAA4, HcIAA6 and HcIAA12, were selected as candidate genes and HcIAA2 and HcIAA4 were screened for further characterization. Downregulation of HcIAA2 and HcIAA4 by virus-induced gene silencing in H. coronarium flowers modified the total volatile compound content, suggesting that HcIAA2 and HcIAA4 play important roles in H. coronarium floral scent formation. The results presented here will provide insights into the putative roles of HcIAA genes and will assist the elucidation of their precise roles during floral scent formation.

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Santama, Niovi, Stephen C. Ogg, Anna Malekkou, Spyros E. Zographos, Karsten Weis, and Angus I. Lamond. "Characterization of hCINAP, a Novel Coilin-interacting Protein Encoded by a Transcript from the Transcription Factor TAFIID32 Locus." Journal of Biological Chemistry 280, no. 43 (August 2, 2005): 36429–41. http://dx.doi.org/10.1074/jbc.m501982200.

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Coilin is a marker protein for the Cajal body, a subnuclear domain acting as a site for assembly and maturation of nuclear RNA-protein complexes. Using a yeast two-hybrid screen to identify coilin-interacting proteins, we have identified hCINAP (human coilin interacting nuclear ATPase protein), a nuclear factor of 172 amino acids with a P-loop nucleotide binding motif and ATPase activity. The hCINAP protein sequence is highly conserved across its full-length from human to plants and yeast and is ubiquitously expressed in all human tissues and cell lines tested. The yeast orthologue of CINAP is a single copy, essential gene. Tagged hCINAP is present in complexes containing coilin in mammalian cells and recombinant, Escherichia coli expressed hCINAP binds directly to coilin in vitro. The 214 carboxyl-terminal residues of coilin appear essential for the interaction with hCINAP. Both immunofluorescence and fluorescent protein tagging show that hCINAP is specifically nuclear and distributed in a widespread, diffuse nucleoplasmic pattern, excluding nucleoli, with some concentration also in Cajal bodies. Overexpression of hCINAP in HeLa cells results in a decrease in the average number of Cajal bodies per nucleus, consistent with it affecting either the stability of Cajal bodies and/or their rate of assembly. The hCINAP mRNA is an alternatively spliced transcript from the TAF9 locus, which encodes the basal transcription factor subunit TAFIID32. However, hCINAP and TAFIID32 mRNAs are translated from different ATG codons and use distinct reading frames, resulting in them having no identity in their respective protein sequences.

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Qu, Linglong, Yapeng Ji, Xi Zhu та Xiaofeng Zheng. "hCINAP negatively regulates NF-κB signaling by recruiting the phosphatase PP1 to deactivate IKK complex". Journal of Molecular Cell Biology 7, № 6 (18 червня 2015): 529–42. http://dx.doi.org/10.1093/jmcb/mjv041.

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Malekkou, Anna, Carsten W. Lederer, Angus I. Lamond, and Niovi Santama. "The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition." FEBS Letters 584, no. 22 (October 23, 2010): 4559–64. http://dx.doi.org/10.1016/j.febslet.2010.10.044.

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Drakou, Christina E., Anna Malekkou, Joseph M. Hayes, Carsten W. Lederer, Demetres D. Leonidas, Nikos G. Oikonomakos, Angus I. Lamond, Niovi Santama, and Spyros E. Zographos. "hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: Structural and functional studies." Proteins: Structure, Function, and Bioinformatics 80, no. 1 (October 31, 2011): 206–20. http://dx.doi.org/10.1002/prot.23186.

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Zhang, Jinfang, Feiyun Zhang, and Xiaofeng Zheng. "Depletion of hCINAP by RNA interference causes defects in Cajal body formation, histone transcription, and cell viability." Cellular and Molecular Life Sciences 67, no. 11 (February 26, 2010): 1907–18. http://dx.doi.org/10.1007/s00018-010-0301-2.

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Xu, Ruidan, Yongfeng Yang, and Xiaofeng Zheng. "Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression." FEBS Letters 595, no. 16 (July 20, 2021): 2071–84. http://dx.doi.org/10.1002/1873-3468.14158.

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Zhang, J., D. Bai, X. Ma, J. Guan, and X. Zheng. "hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14." Oncogene 33, no. 2 (December 17, 2012): 246–54. http://dx.doi.org/10.1038/onc.2012.560.

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Zhuge, Ruipeng, Chao Wang, Jie Wang, Shuyu Yu, Liming Liao, and Xiaofeng Zheng. "hCINAP regulates the differentiation of embryonic stem cells by regulating NEDD4 liquid-liquid phase-separation-mediated YAP1 activation." Cell Reports 42, no. 1 (January 2023): 111935. http://dx.doi.org/10.1016/j.celrep.2022.111935.

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St-Arnaud, René, Alice Arabian, Dila Kavame, Martin Kaufmann, and Glenville Jones. "Vitamin D and Diseases of Mineral Homeostasis: A Cyp24a1 R396W Humanized Preclinical Model of Infantile Hypercalcemia Type 1." Nutrients 14, no. 15 (August 6, 2022): 3221. http://dx.doi.org/10.3390/nu14153221.

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Infantile hypercalcemia type 1 (HCINF1), previously known as idiopathic infantile hypercalcemia, is caused by mutations in the 25-hydroxyvitamin D 24-hydroxylase gene, CYP24A1. The R396W loss-of-function mutation in CYP24A1 is the second most frequent mutated allele observed in affected HCINF1 patients. We have introduced the site-specific R396W mutation within the murine Cyp24a1 gene in knock-in mice to generate a humanized model of HCINF1. On the C57Bl6 inbred background, homozygous mutant mice exhibited high perinatal lethality with 17% survival past weaning. This was corrected by crossbreeding to the CD1 outbred background. Mutant animals had hypercalcemia in the first week of life, developed nephrolithiasis, and had a very high 25(OH)D3 to 24,25(OH)2D3 ratio which is a diagnostic hallmark of the HCINF1 condition. Expression of the mutant Cyp24a1 allele was highly elevated while Cyp27b1 expression was abrogated. Impaired bone fracture healing was detected in CD1-R396w/w mutant animals. The augmented lethality of the C57Bl6-R396W strain suggests an influence of distinct genetic backgrounds. Our data point to the utility of unique knock-in mice to probe the physiological ramifications of CYP24A1 variants in isolation from other biological and environmental factors.

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Дисертації з теми "Hcinap"

Duflocq, Stéphane. "Conception et évaluation de peptides inhibiteurs de l'interaction ribosomale hCINAP/RPS14 dans un but antitumoral." Thesis, Université Paris Cité, 2021. http://www.theses.fr/2021UNIP5041.

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En réponse à différents stress, la protéine p53 est activée afin de promouvoir des changements de métabolisme, l'arrêt du cycle cellulaire et la réparation de l'ADN. En cas de trop fortes mutations, cette protéine peut aussi entraîner l'autodestruction de la cellule. Ce mécanisme de mort cellulaire programmée, appelé apoptose, s'opère naturellement dès le stade embryonnaire et permet de réguler le stock cellulaire. Ce rôle essentiel est néanmoins inactivé dans les cellules cancéreuses où dans la moitié des cas, p53 est mutée. La protéine HDM2 entraîne la dégradation de p53 par ubiquitinylation permettant ainsi aux cellules cancéreuses d'échapper à ce contrôle malgré leur forte dégénérescence. L'inhibition à différents niveaux de la biogenèse des ribosomes conduit à la stabilisation et à l'accumulation de p53. Ce processus finement régulé fait appel à près de 200 facteurs d'assemblage, dont hCINAP. Celui-ci entre notamment en interaction avec la protéine ribosomale RPS14 durant la dernière étape de maturation de la petite sous-unité ribosomique. Seule, RPS14 a la propriété de se lier à HMD2 et de lever l'inhibition de p53. L'objectif de cette thèse repose sur la synthèse chimique d'inhibiteurs peptidiques ciblant l'interaction hCINAP/RPS14 dans le but de restaurer l'activité de p53 et de perturber la biogenèse des ribosomes entraînant un double effet antitumoral. Ce travail s'appuie sur une structure cristallographique de Fap7, homologue archée de hCINAP, en complexe avec RPS14. En mimant la boucle C-terminale de RPS14, ces peptides cycliques innovants ont pour but de promouvoir la liaison RPS14/HDM2. Des méthodes de ligation peptidiques portant sur le noyau thiazolidine pour la liaison oxime ont été mises au point conjointement à l'évaluation in vitro et in cellulo des peptides cycliques. Appliquées à la conjugaison avec un peptide de pénétration cellulaire, ces méthodes ont montré que ces inhibiteurs vectorisés présentent un effet anticancéreux prometteur
In response to several stresses, p53 protein is activated to promote metabolic changes, cell cycle arrest and DNA repair. In case of strong DNA damages, this protein can also lead to the self-destruction of the cell. This mechanism of programmed cell death, called apoptosis, naturally occurs from the embryonic stage and regulates the cell stock. Nevertheless, this essential role is inactivated in cancer cells where, in half of the cases, p53 is mutated. HDM2 protein causes the degradation of p53 by polyubiquitinylation thus allowing cancer cells to escape this control despite their strong degeneration. Inhibition at different levels of ribosome biogenesis leads to the stabilization and accumulation of p53. This finely regulated process uses nearly 200 assembly factors, including hCINAP. This factor interacts with the ribosomal protein RPS14 during the last stage of maturation of the small ribosomal subunit. RPS14 can also bind HMD2 and release the inhibition of p53. The aim of this thesis remains on the chemical synthesis of peptide inhibitors targeting the hCINAP/RPS14 interaction to restore the activity of p53 and disturb ribosome biogenesis to trigger a dual antitumor effect. This work is based on a crystallographic structure of Fap7, archaeal form of hCINAP, in complex with RPS14. By mimicking the C-terminal loop of RPS14, these innovative cyclic peptides aim to promote RPS14/HDM2 binding. Peptide ligation methods using thiazolidine ring for oxime bond have been developed in conjunction with the in vitro and in cellulo evaluation of cyclic peptides. Vectorized inhibitors derived from this conjugation methods with a cell penetrating peptide exhibited a promising anticancer effect

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Книги з теми "Hcinap"

Hotel, Catering and Institutional Management Association. HCIMA reference book. London: Sterling, 1989.

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Hotel, Catering and Institutional Management Association. HCIMA reference book. London: Sterling, 1991.

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Hotel, Catering and Institutional Management Association. HCIMA reference book. London: Sterling, 1992.

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Hotel Catering and Institutional Management Association. HCIMA reference book. London: Stirling Publications Ltd., 1985.

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Hotel, Catering and Institutional Management Association. HCIMA reference book. London: Sterling, 1986.

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Hotel, Catering and Institutional Management Association. HCIMA reference book. London: Sterling, 1988.

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Hotel, Catering and Institutional Management Association. HCIMA reference book. London: Sterling, 1993.

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Hotel, Catering and Institutional Management Association. HCIMA reference book. London: Sterling Publications, 1987.

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Official (ISC)² guide to the HCISPP CBK. Boca Raton, FL: CRC Press, Taylor & Francis Group, 2015.

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Amsterdam), Hotel Catering and Institutional Management Association (Conference) (1994. European hospitality management: HCIMA Conference, [held] Amsterdam, 25-26 March 1994. Amsterdam: HCIMA, 1994.

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Частини книг з теми "Hcinap"

Lindsay, Valerie, Michel Rod, and Nicholas Ashill. "Home Country Institutional Agents (HCIAs) as Boundary Spanners Supporting SME Internationalization." In Advances in Global Marketing, 99–124. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-61385-7_5.

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Virtue, Timothy, and Justin Rainey. "Introduction." In HCISPP Study Guide, 1–4. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-802043-2.00001-x.

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Virtue, Timothy, and Justin Rainey. "Healthcare Industry." In HCISPP Study Guide, 5–31. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-802043-2.00002-1.

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Virtue, Timothy, and Justin Rainey. "Regulatory Environment." In HCISPP Study Guide, 33–60. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-802043-2.00003-3.

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Virtue, Timothy, and Justin Rainey. "Privacy and Security in Healthcare." In HCISPP Study Guide, 61–89. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-802043-2.00004-5.

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Virtue, Timothy, and Justin Rainey. "Information Governance and Risk Management." In HCISPP Study Guide, 91–130. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-802043-2.00005-7.

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Virtue, Timothy, and Justin Rainey. "Information Risk Assessment." In HCISPP Study Guide, 131–66. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-802043-2.00006-9.

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Virtue, Timothy, and Justin Rainey. "Third-Party Risk Management." In HCISPP Study Guide, 167–83. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-802043-2.00007-0.

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"Front matter." In HCISPP Study Guide, iii. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-802043-2.00008-2.

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"Copyright." In HCISPP Study Guide, iv. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-802043-2.00009-4.

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Тези доповідей конференцій з теми "Hcinap"

Calderon, Roberto, Sidney Fels, Junia Anacleto, Nemanja Memarovic, and W. Travis Thompson. "Hacking HCI3P." In the 2014 companion publication. New York, New York, USA: ACM Press, 2014. http://dx.doi.org/10.1145/2598784.2598797.

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Amuboh, Okiemute, Tekena Manuel, Yahaya Yunana, Ejiuwa Nworie, and Remmy Ugboaja. "Pitfalls in Channel Reservoirs Development: Implications for HCIIP Assessment and Development." In SPE Nigeria Annual International Conference and Exhibition. Society of Petroleum Engineers, 2017. http://dx.doi.org/10.2118/189111-ms.

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Sultana, Sharifa, Renwen Zhang, Hajin Lim, and Maria Antoniak. "Narrative Datasets through the Lenses of NLP and HCI." In Proceedings of the Second Workshop on Bridging Human--Computer Interaction and Natural Language Processing. Stroudsburg, PA, USA: Association for Computational Linguistics, 2022. http://dx.doi.org/10.18653/v1/2022.hcinlp-1.7.

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Titung, Rajesh, and Cecilia Alm. "Teaching Interactively to Learn Emotions in Natural Language." In Proceedings of the Second Workshop on Bridging Human--Computer Interaction and Natural Language Processing. Stroudsburg, PA, USA: Association for Computational Linguistics, 2022. http://dx.doi.org/10.18653/v1/2022.hcinlp-1.6.

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Dacon, Jamell. "Towards a Deep Multi-layered Dialectal Language Analysis: A Case Study of African-American English." In Proceedings of the Second Workshop on Bridging Human--Computer Interaction and Natural Language Processing. Stroudsburg, PA, USA: Association for Computational Linguistics, 2022. http://dx.doi.org/10.18653/v1/2022.hcinlp-1.8.

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Soper, Elizabeth, Erin Pacquetet, Sougata Saha, Souvik Das, and Rohini Srihari. "Let’s Chat: Understanding User Expectations in Socialbot Interactions." In Proceedings of the Second Workshop on Bridging Human--Computer Interaction and Natural Language Processing. Stroudsburg, PA, USA: Association for Computational Linguistics, 2022. http://dx.doi.org/10.18653/v1/2022.hcinlp-1.5.

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Barale, Claire. "Human-centered computing in legal NLP - An application to refugee status determination." In Proceedings of the Second Workshop on Bridging Human--Computer Interaction and Natural Language Processing. Stroudsburg, PA, USA: Association for Computational Linguistics, 2022. http://dx.doi.org/10.18653/v1/2022.hcinlp-1.4.

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McMillan-Major, Angelina, Amandalynne Paullada, and Yacine Jernite. "An Interactive Exploratory Tool for the Task of Hate Speech Detection." In Proceedings of the Second Workshop on Bridging Human--Computer Interaction and Natural Language Processing. Stroudsburg, PA, USA: Association for Computational Linguistics, 2022. http://dx.doi.org/10.18653/v1/2022.hcinlp-1.2.

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Girju, Roxana, and Marina Girju. "Design Considerations for an NLP-Driven Empathy and Emotion Interface for Clinician Training via Telemedicine." In Proceedings of the Second Workshop on Bridging Human--Computer Interaction and Natural Language Processing. Stroudsburg, PA, USA: Association for Computational Linguistics, 2022. http://dx.doi.org/10.18653/v1/2022.hcinlp-1.3.

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Surdeanu, Mihai, John Hungerford, Yee Seng Chan, Jessica MacBride, Benjamin Gyori, Andrew Zupon, Zheng Tang, et al. "Taxonomy Builder: a Data-driven and User-centric Tool for Streamlining Taxonomy Construction." In Proceedings of the Second Workshop on Bridging Human--Computer Interaction and Natural Language Processing. Stroudsburg, PA, USA: Association for Computational Linguistics, 2022. http://dx.doi.org/10.18653/v1/2022.hcinlp-1.1.

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