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Опубліковано: 8 червня 2024

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Статті в журналах з теми "Generation of negative triples":

Vallée-Tourangeau, Frédéric, Neville G. Austin, and Sandra Rankin. "Inducing a Rule in Wason's 2–4–6 Task: A Test of the Information-Quantity and Goal-Complementarity Hypotheses." Quarterly Journal of Experimental Psychology Section A 48, no. 4 (November 1995): 895–914. http://dx.doi.org/10.1080/14640749508401422.

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In the standard 2–4–6 induction task, subjects are instructed to discover the rule generating sequences of three numbers by inventing number triples for which they receive immediate feedback. The rule is “ascending numbers”. Performance is greatly aided with Dual Goal (DG) instructions that ask subjects to discover two rules, one that generates “Dax” triples (equivalent to “yes” instances with Single Goal [SG] instructions) and another that generates “Med” triples (equivalent to “no” instances). The present study eliminates two explanations for this effect suggested by Wharton, Cheng, and Wickens (1993). Experiment 1 tested their Information-Quantity hypothesis that the effect results simply from the DG subjects testing more triples prior to proposing a rule. Our DG subjects were more likely to solve the problem and produced more “negative” triples than SG subjects when both groups generated exactly 15 triples. Two further groups received feedback only after generating all 15 triples, and again DG subjects were more likely to solve the problem and to generate more “negative” triples. Experiment 2 tested Wharton et al.'s Goal-Complementarity hypothesis that success under DG instructions hinges on preserving the complementary representation of the two rules. We compared SG instructions with three types of DG instructions that suggested different types of triples (Dax, Med, both Dax and Med, neither Dax nor Med). DG instructions were more effective in promoting successful rule discovery regardless of differences in rule complementarity. Our analysis of the heterogeneity of the examplars generated with DG instructions in both experiments suggest that success on the 2–4–6 task is as much a consequence of the breadth of hypotheses that subjects entertain as it is a consequence of the testing strategy.

Vallée-Tourangeau, Frédéric. "Utilities in the 2-4-6 Task." Experimental Psychology 59, no. 5 (May 1, 2012): 265–71. http://dx.doi.org/10.1027/1618-3169/a000152.

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The Wason 2-4-6 task was embedded in a practical reasoning scenario where number sequences had well-defined utilities in the process of achieving a goal. Reasoners’ hypothesis-testing behavior was clearly goal-driven and was significantly influenced by whether the utilities favored positive or negative sequences. In the version of the scenario where generating positive sequences had greater benefits than generating negative ones, participants performed poorly at the task as measured by their ability to guess the correct rule and by the nature and number of triples tested before making an announcement. In contrast, the scenario that assigned a greater utility to the production of negative sequences fostered significantly more diligent and creative hypothesis-testing behavior, and participants were significantly more likely to discover the rule. These results suggest that the poor performance observed in Wason’s traditional 2-4-6 task reflects a hypothesis-testing process that by default assigns greater utility to the production of sequences that conform to the initial triple, and hence receive positive feedback. However, reasoners are not averse to producing negative sequences, and understand their implication, if their utility is made relevant in the process of achieving goals.

Wang, Liuquan. "Arithmetic identities and congruences for partition triples with 3-cores." International Journal of Number Theory 12, no. 04 (April 10, 2016): 995–1010. http://dx.doi.org/10.1142/s1793042116500627.

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Let [Formula: see text] denote the number of partition triples of [Formula: see text] where each partition is 3-core. With the help of generating function manipulations, we find several infinite families of arithmetic identities and congruences for [Formula: see text]. Moreover, let [Formula: see text] denote the number of representations of a non-negative integer [Formula: see text] in the form [Formula: see text] with [Formula: see text] We find three arithmetic relations between [Formula: see text] and [Formula: see text], such as [Formula: see text].

Tierno, Domenico, Gabriele Grassi, Serena Scomersi, Marina Bortul, Daniele Generali, Fabrizio Zanconati, and Bruna Scaggiante. "Next-Generation Sequencing and Triple-Negative Breast Cancer: Insights and Applications." International Journal of Molecular Sciences 24, no. 11 (June 2, 2023): 9688. http://dx.doi.org/10.3390/ijms24119688.

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The poor survival of triple-negative breast cancer (TNBC) is due to its aggressive behavior, large heterogeneity, and high risk of recurrence. A comprehensive molecular investigation of this type of breast cancer using high-throughput next-generation sequencing (NGS) methods may help to elucidate its potential progression and discover biomarkers related to patient survival. In this review, the NGS applications in TNBC research are described. Many NGS studies point to TP53 mutations, immunocheckpoint response genes, and aberrations in the PIK3CA and DNA repair pathways as recurrent pathogenic alterations in TNBC. Beyond their diagnostic and predictive/prognostic value, these findings suggest potential personalized treatments in PD -L1-positive TNBC or in TNBC with a homologous recombination deficit. Moreover, the comprehensive sequencing of large genomes with NGS has enabled the identification of novel markers with clinical value in TNBC, such as AURKA, MYC, and JARID2 mutations. In addition, NGS investigations to explore ethnicity-specific alterations have pointed to EZH2 overexpression, BRCA1 alterations, and a BRCA2-delaAAGA mutation as possible molecular signatures of African and African American TNBC. Finally, the development of long-read sequencing methods and their combination with optimized short-read techniques promise to improve the efficiency of NGS approaches for future massive clinical use.

Wu, Jiande, Tarun K. K. Mamidi, Lu Zhang, and Chindo Hicks. "Delineation of the Germline and Somatic Mutation Interaction Landscape in Triple-Negative and Non-Triple-Negative Breast Cancer." International Journal of Genomics 2020 (July 7, 2020): 1–16. http://dx.doi.org/10.1155/2020/2641370.

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Background. Breast cancer development and progression involve both germline and somatic mutations. High-throughput genotyping and next-generation sequencing technologies have enabled discovery of genetic risk variants and acquired somatic mutations driving the disease. However, the possible oncogenic interactions between germline genetic risk variants and somatic mutations in triple-negative breast cancer (TNBC) and non-triple-negative breast cancer (non-TNBC) have not been characterized. Here, we delineated the possible oncogenic interactions between genes containing germline and somatic mutations in TNBC and non-TNBC and investigated whether there are differences in gene expression and mutation burden between the two types of breast cancer. Methods. We addressed this problem by integrating germline mutation information from genome-wide association studies with somatic mutation information from next-generation sequencing using gene expression data as the intermediated phenotype. We performed network and pathway analyses to discover molecular networks and signalling pathways enriched for germline and somatic mutations. Results. The investigation revealed signatures of differentially expressed and differentially somatic mutated genes between TNBC and non-TNBC. Network and pathway analyses revealed functionally related genes interacting in gene regulatory networks and multiple signalling pathways enriched for germline and somatic mutations for each type of breast cancer. Among the signalling pathways discovered included the DNA repair and Androgen and ATM signalling pathways for TNBC and the DNA damage response, molecular mechanisms of cancer, and ATM and GP6 signalling pathways for non-TNBC. Conclusions. The results show that integrative genomics is a powerful approach for delineating oncogenic interactions between genes containing germline and genes containing somatic mutations in TNBC and non-TNBC and establishes putative functional bridges between genetic and somatic alterations and the pathways they control in the two types of breast cancer.

Lin, Po‐Han, Ming Chen, Li‐Wei Tsai, Chiao Lo, Tzu‐Chun Yen, Thomas Yoyan Huang, Chih‐Kai Chen, Sheng‐Chih Fan, Sung‐Hsin Kuo, and Chiun‐Sheng Huang. "Using next‐generation sequencing to redefine BRCAness in triple‐negative breast cancer." Cancer Science 111, no. 4 (February 19, 2020): 1375–84. http://dx.doi.org/10.1111/cas.14313.

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Wu, Jiande, Tarun Karthik Kumar Mamidi, Lu Zhang, and Chindo Hicks. "Unraveling the Genomic-Epigenomic Interaction Landscape in Triple Negative and Non-Triple Negative Breast Cancer." Cancers 12, no. 6 (June 12, 2020): 1559. http://dx.doi.org/10.3390/cancers12061559.

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Background: The recent surge of next generation sequencing of breast cancer genomes has enabled development of comprehensive catalogues of somatic mutations and expanded the molecular classification of subtypes of breast cancer. However, somatic mutations and gene expression data have not been leveraged and integrated with epigenomic data to unravel the genomic-epigenomic interaction landscape of triple negative breast cancer (TNBC) and non-triple negative breast cancer (non-TNBC). Methods: We performed integrative data analysis combining somatic mutation, epigenomic and gene expression data from The Cancer Genome Atlas (TCGA) to unravel the possible oncogenic interactions between genomic and epigenomic variation in TNBC and non-TNBC. We hypothesized that within breast cancers, there are differences in somatic mutation, DNA methylation and gene expression signatures between TNBC and non-TNBC. We further hypothesized that genomic and epigenomic alterations affect gene regulatory networks and signaling pathways driving the two types of breast cancer. Results: The investigation revealed somatic mutated, epigenomic and gene expression signatures unique to TNBC and non-TNBC and signatures distinguishing the two types of breast cancer. In addition, the investigation revealed molecular networks and signaling pathways enriched for somatic mutations and epigenomic changes unique to each type of breast cancer. The most significant pathways for TNBC were: retinal biosynthesis, BAG2, LXR/RXR, EIF2 and P2Y purigenic receptor signaling pathways. The most significant pathways for non-TNBC were: UVB-induced MAPK, PCP, Apelin endothelial, Endoplasmatic reticulum stress and mechanisms of viral exit from host signaling Pathways. Conclusion: The investigation revealed integrated genomic, epigenomic and gene expression signatures and signing pathways unique to TNBC and non-TNBC, and a gene signature distinguishing the two types of breast cancer. The study demonstrates that integrative analysis of multi-omics data is a powerful approach for unravelling the genomic-epigenomic interaction landscape in TNBC and non-TNBC.

Raftery, Martin J., Alexander Sebastian Franzén, Clarissa Radecke, Abdelhadi Boulifa, Günther Schönrich, Sebastian Stintzing, Jens-Uwe Blohmer, and Gabriele Pecher. "Next Generation CD44v6-Specific CAR-NK Cells Effective against Triple Negative Breast Cancer." International Journal of Molecular Sciences 24, no. 10 (May 20, 2023): 9038. http://dx.doi.org/10.3390/ijms24109038.

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There is a medical need to develop new and effective therapies against triple-negative breast cancer (TNBC). Chimeric antigen receptor (CAR) natural killer (NK) cells are a promising alternative to CAR-T cell therapy for cancer. A search for a suitable target in TNBC identified CD44v6, an adhesion molecule expressed in lymphomas, leukemias and solid tumors that is implicated in tumorigenesis and metastases. We have developed a next-generation CAR targeting CD44v6 that incorporates IL-15 superagonist and checkpoint inhibitor molecules. We could show that CD44v6 CAR-NK cells demonstrated effective cytotoxicity against TNBC in 3D spheroid models. The IL-15 superagonist was specifically released upon recognition of CD44v6 on TNBC and contributed to the cytotoxic attack. PD1 ligands are upregulated in TNBC and contribute to the immunosuppressive tumor microenvironment (TME). Competitive inhibition of PD1 neutralized inhibition by PD1 ligands expressed on TNBC. In total, CD44v6 CAR-NK cells are resistant to TME immunosuppression and offer a new therapeutic option for the treatment of BC, including TNBC.

Zhang, Zhenghang, Jinlu Jia, Yalin Wan, Yang Zhou, Yuting Kong, Yurong Qian, and Jun Long. "TransR*: Representation learning model by flexible translation and relation matrix projection." Journal of Intelligent & Fuzzy Systems 40, no. 5 (April 22, 2021): 10251–59. http://dx.doi.org/10.3233/jifs-202177.

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The TransR model solves the problem that TransE and TransH models are not sufficient for modeling in public spaces, and is considered a highly potential knowledge representation model. However, TransR still adopts the translation principles based on the TransE model, and the constraints are too strict, which makes the model’s ability to distinguish between very similar entities low. Therefore, we propose a representation learning model TransR* based on flexible translation and relational matrix projection. Firstly, we separate entities and relationships in different vector spaces; secondly, we combine our flexible translation strategy to make translation strategies more flexible. During model training, the quality of generating negative triples is improved by replacing semantically similar entities, and the prior probability of the relationship is used to distinguish the relationship of similar coding. Finally, we conducted link prediction experiments on the public data sets FB15K and WN18, and conducted triple classification experiments on the WN11, FB13, and FB15K data sets to analyze and verify the effectiveness of the proposed model. The evaluation results show that our method has a better improvement effect than TransR on Mean Rank, Hits@10 and ACC indicators.

Ben-Baruch, Noa, Tamar Peretz-Yablonski, Georgeta Fried, Moshe J. Inbar, Yousef Samih, Victoria Neiman, Bella Nisenbaum, et al. "Next-generation sequencing (NGS) in relapsed/refractory triple-negative breast cancer (TNBC) in Israel." Journal of Clinical Oncology 32, no. 15_suppl (May 20, 2014): 1028. http://dx.doi.org/10.1200/jco.2014.32.15_suppl.1028.

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Дисертації з теми "Generation of negative triples":

Vitiello, Adriana. "Generation and characterization of HSV-1 based oncolytic viruses towards an innovative therapeutic approach for TNBC." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3422208.

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BACKGROUND Immunotherapy, mainly based on checkpoint inhibitors or Chimeric Antigen Receptor (CAR) T cells, is providing a major breakthrough in the pharmacological therapy of cancer. However, many solid tumors surrounded by an immunosuppressive tumor microenvironment (TME), like triple negative breast carcinoma (TNBC), do not have a cytotoxic T lymphocyte infiltrate that can be activated by checkpoint inhibitors (“cold” tumors). Oncolytic viruses (OVs) are able to selectively replicate in cancerous cells, which are often defective in antiviral response pathways. OVs provide a powerful proinflammatory stimulus in the TME, thus subverting its immunosuppressive features. Therefore, OVs are very promising agents for the immunotherapeutic treatment of immunologically “cold” tumors. At the same time, OVs can be “armed” to express therapeutic molecules that enhance their efficacy. Herpes simplex virus type 1 (HSV-1) proved to be a suitable platform for the generation of OVs, due to its large dsDNA genome, which allows extensive manipulation and insertion of therapeutic genes, to its lytic activity and good safety profile. HSV-1 derived OVs usually carry deletions of the γ34.5 gene, which is essential for neurovirulence. The HSV-1 based talimogene laherparepvec (T-VEC) is the only OV approved for clinical use (metastatic melanoma) in the EU and the USA so far. METHODS Bacterial artificial chromosome (BAC) mutagenesis in an appropriate strain of Escherichia coli, that is characterized by the inducible expression of a recombinase system, was adopted for the manipulation of the HSV-1 genome. In particular, mutagenesis was performed on a previously available Δγ34.5 HSV-1 BAC. Viral stocks were then reconstituted by lipofectamine transfection of purified BAC DNA into 293T cells. We tested the selectivity and the replicative capacity of the recombinant viruses in a panel of human mammary cancer cell lines as well as in both tumoral and non-tumoral murine mammary organoids. The efficiency of expression of transgenes was also evaluated by different methods. RESULTS AND CONCLUSIONS The Us12 gene, encoding the ICP47 protein, was succesfully deleted from the parental BAC. The Us12 deletion enhances MHC-I antigen presentation by infected cells, and shifts the expression kinetics of the Us11 gene from late to immediate early, boosting viral replication without affecting safety. First of all a recombinant virus was generated by the insertion within the UL55-UL56 intergenic region of the enhanced green fluorescent protein (EGFP) gene. The recombinant virus showed specificity for tumoral organoids and efficiently killed cancer cells. Based on these findings, two additional recombinant viruses were developed by replacing the EGFP gene with a sequence encoding either i) a single chain antibody (scAb) targeting C-C Chemokine Receptor Type 4 (CCR4) or ii) the solubile Programmed cell Death-1 (sPD1) protein. Both recombinant viruses efficiently replicated in the tested cell lines. Exogenous genes were also expressed. To address the immunological complexity of the TME, we are inserting further therapeutic genes, including human IL-12, and FMS-like tyrosine kinase 3 ligand (Flt3L) in the Δγ34.5/ΔUs12 BAC. Next steps will be a deep in vitro characterization of the developed OVs and testing viral therapeutic efficacy on an appropriate mouse model.

Vougiouklis, Pavlos. "Neural generation of textual summaries from knowledge base triples." Thesis, University of Southampton, 2019. https://eprints.soton.ac.uk/428045/.

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Most people need textual or visual interfaces in order to make sense of Semantic Web data. In this thesis, we investigate the problem of generating natural language summaries for structured data encoded as triples using neural networks. We propose an end-to-end trainable architecture that encodes the information from a set of triples into a vector of fixed dimensionality and generates a textual summary by conditioning the output on this encoded vector. In order to both train and evaluate the performance of our approach, we explore different methodologies for building the required data-to-text corpora. We initially focus our attention on the generation of biographies. Using methods for both automatic and human evaluation, we demonstrated that our technique is capable of scaling to domains with challenging vocabulary sizes of over 400k words. Given the promising results of our approach in biographies, we explore its applicability in the generation of open-domain Wikipedia summaries in two under-resourced languages, Arabic and Esperanto. We propose an adaptation of our original encoder-decoder architecture that outperforms a set of strong baselines of different nature. Furthermore, we conducted a set of community studies in order to measure the usability of the generated content by Wikipedia readers and editors. The targeted communities ranked our generated text close to the expected standards of Wikipedia. In addition, we found that the editors are likely to reuse a large portion of the generated summaries, thus, emphasizing the usefulness of our approach to the involved communities. Finally, we extend the original model with a pointer mechanism that enables it to jointly learn to verbalise in a different number of ways the content from the triples while retaining the ability to generate regular words from a fixed target vocabulary. We evaluate performance with a dataset encompassing the entirety of English Wikipedia. Results from both automatic and human evaluation highlight the superiority of the latter approach compared to our original encoder-decoder architecture and a set of competitive baselines.

Islam, Md Kamrul. "Explainable link prediction in large complex graphs - application to drug repurposing." Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0203.

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De nombreux systèmes complexes du monde réel peuvent être représentés par des graphes, où les nœuds représentent des entités et les liens des relations entre les paires de nœuds. La prédiction de liens (LP) est l'un des problèmes les plus intéressants et les plus anciens dans le domaine de l'exploration de graphes ; elle prédit la probabilité d'un lien entre deux nœuds non connectés. Cette thèse étudie le problème LP dans les graphes simples et les graphes de connaissances (KGs). La première partie de cette thèse se concentre sur le problème LP dans les graphes simples. Dans la première étude, des approches basées sur la similarité et sur l'encastrement sont évaluées et comparées sur des graphes simples de différents domaines. L'étude a également identifié la difficulté de fixer le seuil du score de similarité pour calculer la métrique de précision des approches basées sur la similarité et a proposé une nouvelle méthode pour calculer la métrique. Les résultats ont montré la supériorité attendue des approches basées sur l'intégration. Cependant, chaque approche basée sur la similarité s'est avérée compétitive sur des graphes aux propriétés spécifiques. Nous avons pu vérifier expérimentalement que les approches basées sur la similarité sont explicables mais manquent de généralisation, tandis que les approches basées sur l'encastrement sont générales mais non explicables. La deuxième étude tente de surmonter la limitation de l'inexplicabilité des approches basées sur l'encastrement en découvrant des connexions intéressantes entre elles et les approches basées sur la similarité. La troisième étude démontre comment les approches basées sur la similarité peuvent être assemblées pour concevoir une approche LP supervisée explicable. Il est intéressant de noter que l'étude montre des performances LP élevées pour l'approche supervisée sur différents graphes, ce qui est très satisfaisant. La deuxième partie de la thèse se concentre sur les LP dans les KGs. Un KG est représenté comme une collection de triplets RDF, (head,relation,tail) où les entités head et tail sont reliées par une relation spécifique. Le problème de LP dans un KG est formulé comme la prédiction de la tête ou de la queue manquante dans un triplet. La LP basée sur l'incorporation de KG est devenue très populaire ces dernières années, et la génération de triplets négatifs est une tâche importante dans les méthodes d'incorporation. La quatrième étude traite d'une nouvelle méthode appelée SNS pour générer des triplets négatifs de haute qualité. Nos résultats montrent une meilleure performance LP lorsque SNS est utilisé que lorsque d'autres méthodes d'échantillonnage négatif sont utilisées. La deuxième étude traite d'une nouvelle méthode d'extraction de règles neuro-symboliques et d'une stratégie d'abduction pour expliquer les LP par une approche basée sur l'intégration en utilisant les règles apprises. La troisième étude applique notre LP explicable pour développer une nouvelle approche de repositionnement des médicaments pour COVID-19. L'approche apprend un ensemble d'enchâssements d'entités et de relations dans un KG centré sur COVID-19 pour obtenir un meilleur enchâssement des éléments du graphe. Pour la première fois à notre connaissance, des méthodes de criblage virtuel sont ensuite utilisées pour évaluer les prédictions obtenues à l'aide des embeddings. L'évaluation moléculaire et les chemins explicatifs apportent de la fiabilité aux résultats de prédiction et sont de nouvelles méthodes complémentaires et réutilisables pour mieux évaluer les molécules proposées pour le repositionnement. La dernière étude propose une architecture distribuée pour l'apprentissage des KG embeddings dans des environnements distribués et parallèles. Les résultats révèlent que l'apprentissage dans l'environnement distribué proposé, par rapport à un apprentissage centralisé, réduit considérablement le temps de calcul des méthodes d'incorporation KG sans affecter les performances des LP
Many real-world complex systems can be well-represented with graphs, where nodes represent objects or entities and links/relations represent interactions between pairs of nodes. Link prediction (LP) is one of the most interesting and long-standing problems in the field of graph mining; it predicts the probability of a link between two unconnected nodes based on available information in the current graph. This thesis studies the LP problem in graphs. It consists of two parts: LP in simple graphs and LP knowledge graphs (KGs). In the first part, the LP problem is defined as predicting the probability of a link between a pair of nodes in a simple graph. In the first study, a few similarity-based and embedding-based LP approaches are evaluated and compared on simple graphs from various domains. he study also criticizes the traditional way of computing the precision metric of similarity-based approaches as the computation faces the difficulty of tuning the threshold for deciding the link existence based on the similarity score. We proposed a new way of computing the precision metric. The results showed the expected superiority of embedding-based approaches. Still, each of the similarity-based approaches is competitive on graphs with specific properties. We could check experimentally that similarity-based approaches are fully explainable but lack generalization due to their heuristic nature, whereas embedding-based approaches are general but not explainable. The second study tries to alleviate the unexplainability limitation of embedding-based approaches by uncovering interesting connections between them and similarity-based approaches to get an idea of what is learned in embedding-based approaches. The third study demonstrates how the similarity-based approaches can be ensembled to design an explainable supervised LP approach. Interestingly, the study shows high LP performance for the supervised approach across various graphs, which is competitive with embedding-based approaches.The second part of the thesis focuses on LP in KGs. A KG is represented as a collection of RDF triples, (head,relation,tail) where the head and the tail are two entities which are connected by a specific relation. The LP problem in a KG is formulated as predicting missing head or tail entities in a triple. LP approaches based on the embeddings of entities and relations of a KG have become very popular in recent years, and generating negative triples is an important task in KG embedding methods. The first study in this part discusses a new method called SNS to generate high-quality negative triples during the training of embedding methods for learning embeddings of KGs. The results we produced show better LP performance when SNS is injected into an embedding approach than when injecting state-of-the-art negative triple sampling methods. The second study in the second part discusses a new neuro-symbolic method of mining rules and an abduction strategy to explain LP by an embedding-based approach utilizing the learned rules. The third study applies the explainable LP to a COVID-19 KG to develop a new drug repurposing approach for COVID-19. The approach learns ”ensemble embeddings” of entities and relations in a COVID-19 centric KG, in order to get a better latent representation of the graph elements. For the first time to our knowledge, molecular docking is then used to evaluate the predictions obtained from drug repurposing using KG embedding. Molecular evaluation and explanatory paths bring reliability to prediction results and constitute new complementary and reusable methods for assessing KG-based drug repurposing. The last study proposes a distributed architecture for learning KG embeddings in distributed and parallel settings. The results of the study that the computational time of embedding methods improves remarkably without affecting LP performance when they are trained in the proposed distributed settings than the traditional centralized settings

Genz, Adrian P. "Operational Amplifier Bandwidth Extension Using Negative Capacitance Generation." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1383.pdf.

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Thilleul, Olivia. "Negative lift generation in a tidal device structure." Thesis, Cranfield University, 2009. http://dspace.lib.cranfield.ac.uk/handle/1826/8292.

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Becoming aware of the impact of global warming, all countries of the European Union have agreed to produce 20% of their electricity from renewable energy by 2020. Hence, a new market emerged to develop more efficient technologies of sustainable power production. Cranfield University has been involved since 2006 in wave and tidal energy design projects through various government agencies funded partnerships with the emerging industry of marine renewable energy. This thesis is based on one of these projects called “DeltaStream” which was developed by Tidal Energy Ltd (TEL). The tidal stream turbine is one of the most efficient concepts in marine renewable energy, because of the high predictability of tidal streams compared to wave and wind energy. Many devices are currently being developed in the UK. Most of them are moored to the seabed using traditional methods used in the offshore oil industry, which means drilling the sea floor. The goal of this work is to avoid drilling the seabed by adding hydrofoils on the structure. Indeed, by setting a hydrofoil in the tidal stream, the goal is to prove that a downward lift force is created and is efficient enough to maintain the structure at its location, avoiding mooring costs and ecological issues relative to drilling the sea floor. Computational Fluid Dynamics (CFD) models have been performed, studying the sensitivity of mesh size compared to results quality, and testing then different hydrofoils to get the best downward lift force in local conditions. The main characteristics of the simulation are unsteady and one phase. The chosen geometry is a “quasi-2D” domain in order to minimize computational requirements. A validation case has been first performed on a well-known geometry of a circular cylinder, to compare analytical results and CFD data. Small variations between results validated the model to enable us to use the model on a less-known simulation such as a hydrofoil. Different parameters influencing the efficiency of the hydrofoil in terms of lift production and drag reduction have been tested. These results have been compared with tank tests undertaken by the OENA Group in June-July 2009 in IFREMER (France). And complementary studies have been performed to compare these results and CFD results.

McLenaghan, Joanna Siân. "Negative frequency waves in optics : control and investigation of their generation and evolution." Thesis, University of St Andrews, 2014. http://hdl.handle.net/10023/6532.

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This thesis is concerned with various methods for the control and investigation of pulse dynamics in a Photonic Crystal Fibre (PCF) and of the radiation driven by a short pulse. In particular the focus is on pulses in the anomalous dispersion region which would form solitons in the absence of higher order effects. Several different types of radiation can be driven by such pulses if they are perturbed by higher order dispersive and non-linear effects - for example Resonant Radiation (RR) and Negative Resonant Radiation (NRR) two dispersive waves which gain energy at the expense of the pulse. The feature of NRR which is of particular importance is that it is the first observed example of a coupling between positive and negative frequencies in optics. This has only been possible due to recent advances in fields such as PCFs, lasers and analogue systems. As with many scientific discoveries, NRR was found by bringing together ideas and techniques from these different fields. Both the pulse and the driven radiation are investigated using a number of different pulse and PCF parameters. These include power, chirp, polarisation and PCF dispersion. These are used to vary the wavelengths at which the driven radiation occurs as well as its generation efficiency. Furthermore the power and chirp are used to vary where in the PCF the driven radiation is generated by controlling where the driving pulse compresses and spectrally expands. This property is used to investigate different stages in the evolution of the pulse and driven radiation as well as to optimise the generation efficiency of the driven radiation.

Kharazi, Alexandra. "Generation and molecular analysis of dominant negative alleles of anthrax lethal factor in Drosophila." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p1453196.

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Thesis (M.S.)--University of California, San Diego, 2008.
Title from first page of PDF file (viewed July 8, 2008). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 26).

Duvvury, Rolan Shawn. "Potential negative effects of wind turbines on the ear." Thesis, Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/44927.

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This thesis presents investigations on the potential negative effects of wind turbine noise on the human ear from a sound point source (i.e. wind farm). In Chapter 2, the tectorial membrane, which is a crucial gelatinous structural matrix located within the cochlea of the inner ear, is considered to have a similar constitutive stress-strain relationship to that of an elastomer (rubber) in tension. The tectorial membrane appears to stretch when subjected to constant heavy sound stimulation. The tectorial membrane is modeled as a simply-supported beam with an external load Pext applied at midspan. A virtual work approach is used to balance the external work at midspan Pextδz of the tectorial membrane with the internal strain energy from its hysteresis loops. These hysteresis loops quantify the amount of damage that the tectorial membrane undergoes due to an applied external loading. Normalized damage tables are presented at the end of the chapter to suggest safe distances away from the wind turbines to limit damage to the tectorial membrane. Chapter 3 considers a hypothetical autonomous village constructed in South Pretoria, South Africa. This village accommodates approximately 2000 people (~500 families) and receives electricity for hot water from a nearby 2.5 MW wind farm. The design process for the village is discussed from an architectural and design standpoint. The wind farm specifications, specifically the number of 2.5 MW wind turbines needed to provide electricity for hot water, are established. Results from Chapter 2 are used to suggest minimum safe distances between the wind farm and the autonomous village in the context of limiting damage to the tectorial membrane.

Agee, Elisha R. "The relationship between second-generation antipsychotic medication adherence and negative symptoms in first-episode schizophrenia." Thesis, Pepperdine University, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3716463.

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Adherence to psychotropic medication is a critical aspect of treatment for the management of psychotic disorders. While the literature on the need for medication adherence is extensive, little research has explored the relationship between the negative symptoms of psychosis and medication adherence. Since negative symptoms are enduring, stable, and strongly correlated with poor outcome, it is vitally important for research to explore the role of negative symptoms in regards to adherence to psychotropic medication. Given its potentially significant consequences for treatment interventions, the purpose of this study was to contribute to the exceedingly limited body of research exploring the relationship between the negative symptoms seen in psychosis and medication adherence. This study examined if there is a relationship between the two and whether causality could be determined should a significant relationship exist between medication adherence and negative symptoms. This study utilized data previously collected at the UCLA Aftercare Research Program for studies examining aspects of outpatient psychiatric treatment. The 148 participants had a mean age of 22.5 years and were in the midst of their first psychotic episode upon study entry. Data from the Brief Psychiatric Rating Scale, Scale for the Assessment of Negative Symptoms, and medication adherence ratings were collected over the course of 12 months. Analyses revealed a significant relationship between the presence of negative symptoms and medication nonadherence. Analyses examining the temporal relationship between the two variables revealed that initial medication nonadherence was significantly associated with subsequent negative symptoms. However, once the impact of positive symptoms was controlled for as a potential mediating variable, the strength of the relationship between medication adherence and negative symptoms dissipated. After controlling for the role of reality distortion, the only negative symptoms significantly associated with medication nonadherence were the BPRS Negative Symptom Factor, BPRS Emotional Withdrawal, and BPRS Self-Neglect. Consequently, it appears that negative symptoms are more strongly associated with positive symptoms than with medication adherence. Replication of these findings and further research exploring the relationship between positive and negative symptoms as they relate to medication adherence is needed in order to improve treatment interventions focused on medication adherence.

Nordeman, Emil. "Generation of Doxycycline-Inducible Cell Lines Expressing Dominant-Negative DNA Polymerase γ and Mitochondrial Helicase Twinkle Variants". Thesis, Umeå universitet, Biomedicinsk laboratorievetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-184253.

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Книги з теми "Generation of negative triples":

Nosachev, Igor', and Dmitriy Romanov. Semiotics of mental illness. General psychopathology. ru: INFRA-M Academic Publishing LLC., 2021. http://dx.doi.org/10.12737/1027396.

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The methodology and systematics of the diagnostic process in psychiatry are given, information is given about psychopathological symptoms and dynamics of the main productive and negative syndromes, including addictive, as well as the most significant forms of norm and pathology of personality. The leading features of clinical and psychopathological research in general psychopathology are substantiated. The section "Symptomatology" reveals the psychological and clinical features of the main mental processes. The section "Syndromology" describes the clinical features of the main positive and negative syndromes, their features in children and adolescents. Meets the requirements of the federal state educational standards of higher education of the latest generation. It is intended for psychiatrists, psychiatrists, narcologists, psychotherapists, clinical psychologists undergoing pre- and postgraduate training, students of higher medical and psychological educational institutions, interns, clinical residents, graduate students and doctors of related disciplines.

Masleeva, Ol'ga, German Pachurin, Aleksandr Sevost'yanov, and Anatoliy Fitasov. Safe operation of power supply systems. ru: INFRA-M Academic Publishing LLC., 2022. http://dx.doi.org/10.12737/1029790.

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The main purpose of the textbook is to identify dangerous and harmful production factors during the operation of electrical equipment of the main step-down substations and transformer substations. Specific measures are proposed to reduce their negative impact on service personnel. Meets the requirements of the federal state educational standards of higher education of the latest generation. For bachelors and masters of full-time and part-time education in the areas of training 13.03.02 and 13.04.02 "Electric power and electrical engineering". It can be used by teachers, engineers and specialists in the operation of industrial equipment and the safe organization of work in production, as well as by a wide range of readers interested in the problems of human life safety.

Grafkina, Marina. Labor protection. ru: INFRA-M Academic Publishing LLC., 2021. http://dx.doi.org/10.12737/1173489.

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The textbook contains information on the legal, regulatory, organizational, and technical bases of labor protection; on the identification of dangerous and harmful factors; and on the impact of various negative factors on human health. Methods and means of protecting a person from the effects of harmful and dangerous industrial factors are disclosed. Meets the requirements of the federal state educational standards of secondary vocational education of the latest generation, approximate educational programs (in terms of the discipline "Labor Protection") in the specialties 15.02.15 "Technology of metalworking production"; 15.02.11 "Technical operation and maintenance of robotic production"; 15.02.14 " Equipment with automation tools for technological processes and production (by industry)". It is intended for students of secondary vocational educational institutions, and can also be used when conducting classes for university students in the main educational programs of the bachelor's degree in the discipline "Labor Protection".

Nikol'skaya, Irina. Information and communication technologies in special education. ru: INFRA-M Academic Publishing LLC., 2020. http://dx.doi.org/10.12737/967120.

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In the textbook examines the complex objective conditions of the process of Informatization of education, in particular the computerization special schools; highlights the positive and negative aspects of using it in education; explain the methodological basis for studying computer science in the special school. Provides an overview of the specialized and non-specialized software, has received the greatest popularity among teachers-practitioners. Special attention is paid to modern technology special training: are explicated possibilities of application of multimedia technologies in educational and correctional purposes, requirements and recommendations for e-textbooks for persons with impaired mental and physical development deals with a set of topical problems associated with distance learning. For extra review provides information on the history and development of information technology, necessary for the modern user of it. Includes checklists, themes, term papers and dissertations, tests for classification and the answers to the tests, a bibliography, and a workshop consisting of 36 practical operations. Meets the requirements of Federal state educational standards of higher education of the last generation. For students of higher educational institutions enrolled in the faculties of defectology.

Fasora, Lukáš, Jan Čermin, Jana Čerminová, Jiří Hanuš, and Michaela Máliková. Sto tváří, sto příběhů. Brno: Masaryk University Press, 2020. http://dx.doi.org/10.5817/cz.muni.m210-9605-2020.

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The book commemorating the centenary of the establishment of the Faculty of Arts is also a contribution to the anniversary of the whole Masaryk University. Its aim is to walk through the history of the faculty by means of a biographical method, i.e., using short biographies that introduce representative, prominent or interesting personalities whose fates and work were connected with the faculty. There was certainly no lack of biographical views in the research of the faculty history, still, such a complex set of biograms has not been collected so far. And the publication offers much more: the authors use a large set of biographical data to interpret the history of the faculty from the perspective of alternating academic generations and contemplate the formative generation experience as well as the phenomena that affected the lives of academics and students over the past 100 years. These include, as a matter of fact, both positive and negative phenomena, therefore, the publication is not just an overview of deserving personalities, respected scientists and charismatic teachers, but it also openly discusses the lives of controversial scholars. Thus, the collection of biograms provides a credible testimony to the one-hundred-year work of the faculty, continually blending studies, science and politics.

Vougiouklis, P. Neural Generation of Textual Summaries from Knowledge Base Triples. IOS Press, Incorporated, 2020.

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Vermeulen, Karla. Generation Disaster. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780190061630.001.0001.

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Generation Disaster: Coming of Age Post-9/11 is an in-depth examination of the multiple stressors that shaped the developmental environment for today’s emerging adults in their youth and as they now take on adult responsibilities in an unprecedentedly complex world. Those stressors include all of the societal changes that occurred in the United States after the attacks of September 11, 2001, as well as other threats like the increase in school shootings and other human-caused disasters, worsening natural disasters and concerns about the future due to climate change, and the global pandemic. The omnipresence of social media amplifies these issues and heightens political divisiveness, while the difficult job market, growing wealth gap between rich and poor, and burden of student debt make many emerging adults doubt they’ll ever find a satisfying career, be able to start a family, or buy a home. As a result, many are stressed out and pessimistic about their futures, yet others are flourishing despite all of the challenges they face. Generation Disaster provides a detailed look into the many forces that are shaping this cohort of emerging adults, drawing on quantitative and qualitative research and including extensive quotations that allow its members to speak for themselves to counter the negative stereotypes older people often perpetuate about them.

Cavanna, Andrea E. Carbamazepine, oxcarbazepine, and eslicarbazepine. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198791577.003.0003.

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Carbamazepine is a first-generation antiepileptic drug characterized by a good range of antiepileptic indications, with acceptable risk of interactions in polytherapy. Carbamazepine has a very good behavioural tolerability profile and is in widespread psychiatric use (indication for bipolar disorder—acute mania). Oxcarbazepine and eslicarbazepine are carbamazepine derivatives. Oxcarbazepine is a second-generation antiepileptic drug characterized by a good range of antiepileptic indications, with acceptable risk of interactions in polytherapy. Like carbamazepine, oxcarbazepine has a very good behavioural tolerability profile and potential for widespread psychiatric use. Eslicarbazepine is a third-generation antiepileptic drug for which clinical experience is still limited. Little is known about its positive and negative psychotropic properties and their implications for the management of behavioural symptoms in patients with epilepsy.

Miyamoto, Seiya, and Nobumi Miyake. Novel treatments and future directions. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198828761.003.0014.

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The advent of new-generation antipsychotic drugs has broadened the options for the pharmacological treatment of schizophrenia. However, there are still medical needs not met by current antipsychotic treatment, particularly for patients with negative symptoms and cognitive impairments, and for treatment-resistant schizophrenia. A growing body of research has identified new molecular mechanisms and novel pharmacological targets for treating schizophrenia beyond just dopamine D2 antagonism. This chapter provides a review of compounds in development and emerging non-pharmacological interventions for schizophrenia, and also considers approaches towards personalized and precision medicine for the disorder.

Fuss, Sabine. The 1.5°C Target, Political Implications, and the Role of BECCS. Oxford University Press, 2017. http://dx.doi.org/10.1093/acrefore/9780190228620.013.585.

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The 2°C target for global warming had been under severe scrutiny in the run-up to the climate negotiations in Paris in 2015 (COP21). Clearly, with a remaining carbon budget of 470–1,020 GtCO2eq from 2015 onwards for a 66% probability of stabilizing at concentration levels consistent with remaining below 2°C warming at the end of the 21st century and yearly emissions of about 40 GtCO2 per year, not much room is left for further postponing action. Many of the low stabilization pathways actually resort to the extraction of CO2 from the atmosphere (known as negative emissions or Carbon Dioxide Removal [CDR]), mostly by means of Bioenergy with Carbon Capture and Storage (BECCS): if the biomass feedstock is produced sustainably, the emissions would be low or even carbon-neutral, as the additional planting of biomass would sequester about as much CO2 as is generated during energy generation. If additionally carbon capture and storage is applied, then the emissions balance would be negative. Large BECCS deployment thus facilitates reaching the 2°C target, also allowing for some flexibility in other sectors that are difficult to decarbonize rapidly, such as the agricultural sector. However, the large reliance on BECCS has raised uneasiness among policymakers, the public, and even scientists, with risks to sustainability being voiced as the prime concern. For example, the large-scale deployment of BECCS would require vast areas of land to be set aside for the cultivation of biomass, which is feared to conflict with conservation of ecosystem services and with ensuring food security in the face of a still growing population.While the progress that has been made in Paris leading to an agreement on stabilizing “well below 2°C above pre-industrial levels” and “pursuing efforts to limit the temperature increase to 1.5°C” was mainly motivated by the extent of the impacts, which are perceived to be unacceptably high for some regions already at lower temperature increases, it has to be taken with a grain of salt: moving to 1.5°C will further shrink the time frame to act and BECCS will play an even bigger role. In fact, aiming at 1.5°C will substantially reduce the remaining carbon budget previously indicated for reaching 2°C. Recent research on the biophysical limits to BECCS and also other negative emissions options such as Direct Air Capture indicates that they all run into their respective bottlenecks—BECCS with respect to land requirements, but on the upside producing bioenergy as a side product, while Direct Air Capture does not need much land, but is more energy-intensive. In order to provide for the negative emissions needed for achieving the 1.5°C target in a sustainable way, a portfolio of negative emissions options needs to minimize unwanted effects on non–climate policy goals.

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Частини книг з теми "Generation of negative triples":

Hayashi, Akitoshi. "Li Negative Electrode." In Next Generation Batteries, 137–42. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-6668-8_13.

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Luo, Shengyue, and Wei Fang. "Potential Probability of Negative Triples in Knowledge Graph Embedding." In Neural Information Processing, 48–58. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-030-04182-3_5.

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Yamada, Yuki. "Concentrated Electrolytes for Lithium Metal Negative Electrodes." In Next Generation Batteries, 37–45. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-6668-8_3.

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Cornejo, M. Eugenia, Jesús Medina, and Eloísa Ramírez-Poussa. "Algebraic Structure of Adjoint Triples Generating a Weak Negation on the Unit Interval." In Rough Sets, 337–48. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-52705-1_25.

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Huang, Jiaqi, Yong Feng, Mingliang Zhou, and Baohua Qiang. "Relationship-Aware Hard Negative Generation in Deep Metric Learning." In Knowledge Science, Engineering and Management, 388–400. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-55393-7_35.

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Zelenov, Sergey, and Sophia Zelenova. "Automated Generation of Positive and Negative Tests for Parsers." In Formal Approaches to Software Testing, 187–202. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/11759744_13.

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Epstein, Daniel, and Ana L. C. Bazzan. "Distributed Coalition Structure Generation with Positive and Negative Externalities." In Progress in Artificial Intelligence, 408–19. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-40669-0_35.

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Wang, Senzhang, Hao Yan, Jinlong Du, Jun Yin, Junxing Zhu, Chaozhuo Li, and Jianxin Wang. "Adversarial Hard Negative Generation for Complementary Graph Contrastive Learning." In Proceedings of the 2023 SIAM International Conference on Data Mining (SDM), 163–71. Philadelphia, PA: Society for Industrial and Applied Mathematics, 2023. http://dx.doi.org/10.1137/1.9781611977653.ch19.

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Mahapatra, Souvik, Narendra Parihar, Subhadeep Mukhopadhyay, and Nilesh Goel. "BTI Analysis Tool (BAT) Model Framework—Generation of Interface Traps." In Recent Advances in PMOS Negative Bias Temperature Instability, 59–80. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-6120-4_4.

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Mahapatra, Souvik, Narendra Parihar, Tarun Samadder, Nilotpal Choudhury, and Akshay Raj. "BTI Analysis Tool (BAT) Model Framework—Generation of Bulk Traps." In Recent Advances in PMOS Negative Bias Temperature Instability, 103–25. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-6120-4_6.

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Тези доповідей конференцій з теми "Generation of negative triples":

Radovich, M., S. Clare, S. Clare, I. Pardo, B. Hancock, G. Sledge, C. Rufenbarger, et al. "Next-Generation Whole Transcriptome Sequencing of Triple-Negative Breast Tumors and Normal Tissues." In Abstracts: Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009; San Antonio, TX. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-09-6134.

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Bansal, Iti, Sudhanshu Tiwari, and Carlos R. Rivero. "The Impact of Negative Triple Generation Strategies and Anomalies on Knowledge Graph Completion." In CIKM '20: The 29th ACM International Conference on Information and Knowledge Management. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3340531.3412023.

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West, DC, DJ Hosfield, CG Mayne, MN Skor, SC Styke, CF Pierce, M. Kocherginsky, et al. "Abstract PD3-02: Second-generation selective glucocorticoid receptor modulators in triple-negative breast cancer." In Abstracts: Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 8-12, 2015; San Antonio, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.sabcs15-pd3-02.

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Radovich, Milan, Susan E. Clare, Ivanesa Pardo, Bradley A. Hancock, Nawal Kassem, George W. Sledge, Connie Rufenbarger, et al. "Abstract 2216: Next-generation whole transcriptome sequencing of triple-negative breast tumors and normal tissues." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-2216.

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Steele, Rebecca E., Simon S. McDade, and Paul B. Mullan. "Abstract 2429: Generation of a transcriptome of oncogenic mutant p53 in triple-negative breast cancer." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-2429.

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Honig, A., T. Martens, S. Häusler, S. Buchholz, B. Rack, J. Wishhusen, J. Dietl, and J. Engel. "Antitumoral Activity of 3rd Generation Derivative Lobaplatin in In Vitro Models of Triple-Negative Breast Cancers." In Abstracts: Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009; San Antonio, TX. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-09-6115.

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Radovich, M., SE Clare, GW Sledge, I. Pardo, T. Mathieson, N. Kassem, BA Hancock, et al. "Abstract PD01-08: Decoding the Transcriptional Landscape of Triple-Negative Breast Cancer Using Next-Generation Whole Transcriptome Sequencing." In Abstracts: Thirty-Third Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 8‐12, 2010; San Antonio, TX. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/0008-5472.sabcs10-pd01-08.

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Shriwas, Pratik, Yanrong Qian, Xuan Wang, Dennis Roberts, Stephen Bergmeier, and Xiaozhuo Chen. "Abstract 2799: New-generation glucose transporter inhibitors targeting non-small cell lung cancer and triple-negative breast cancer." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-2799.

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Lips, Esther H., Magali Michaut, Marlous L. Hoogstraat, Lennart Mulder, Nicolle Besselink, Marco J. Koudijs, Emile E. Voest, et al. "Abstract P3-06-21: Next generation sequencing to find predictors for chemotherapy response in triple negative breast cancer." In Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 9-13, 2014; San Antonio, TX. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.sabcs14-p3-06-21.

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Solzak, Jeffrey P., Rutuja Atale, and Milan Radovich. "Abstract 4403: Next-generation RNA sequencing identifies UHRF1 as a key regulatory protein in triple-negative breast cancer survival." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-4403.

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Звіти організацій з теми "Generation of negative triples":

Molloway, Jamie N., and Dorrays El-Ashry. Downstream Signaling Mechanism Underlying MAPK-Induced Generation of the ERA-Negative Phenotype. Fort Belvoir, VA: Defense Technical Information Center, July 2002. http://dx.doi.org/10.21236/ada410214.

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Holloway, Jamie N. Downstream Signaling Mechanism Underlying MAPK-Induced Generation of the ER-Negative Phenotype. Fort Belvoir, VA: Defense Technical Information Center, July 2004. http://dx.doi.org/10.21236/ada430401.

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Mohammadian, Abolfazl, Ehsan Rahimi, Mohammadjavad Javadinasr, Ali Shamshiripour, Amir Davatgari, Afshin Allahyari, and Talon Brown. Analyzing the Impacts of a Successful Diffusion of Shared E-Scooters and Other Micromobility Devices and Efficient Management Strategies for Successful Operations in Illinois. Illinois Center for Transportation, May 2022. http://dx.doi.org/10.36501/0197-9191/22-006.

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Active transportation can play an important role in promoting more physically active and positive public health outcomes. While walking and biking provide significant physical health benefits, their modal share remains low. As a new form of micromobility service, shared e-scooters can enhance the suite of options available in cities to promote active transportation and fill in the gaps when walking or biking are not preferred. Although e-scooters show potential as a mode of transportation, it is unclear whether people will adopt the technology for everyday use. Furthermore, shared micromobility (e.g., electric scooters) is gaining attention as a complementary mode to public transit and is expected to offer a solution to access/egress for public transit. However, few studies have analyzed integrated usage of shared e-scooters and public transit systems while using panel data to measure spatial and temporal characteristics. This study aims to examine the adoption and frequency of shared e-scooter usage and provide policy implementation. To do so, the researchers launched a survey in the Chicago region in late 2020 and collected a rich data set that includes residents’ sociodemographic details and frequency of shared e-scooter use. To characterize the frequency, the researchers used an ordered probit structure. The findings show that respondents who are male, low income, Millennials and Generation Z, or do not have a vehicle are associated with a higher frequency of shared e-scooter use. Furthermore, this study utilizes shared e-scooter trips for a 35-day measurement period from 10 shared e-scooter operators in Chicago, where the researchers used a random-parameter negative binomial modeling approach to analyze panel effects. The findings highlight the critical role of spatial and temporal characteristics in the integration of shared e-scooters with transit.

Oviedo, Daniel, Orlando Sabogal-Cardona, and Lynn Scholl. Ready to ride: security and transit-related determinants of ride-hailing adoption in Latin America. Inter-American Development Bank, February 2023. http://dx.doi.org/10.18235/0004656.

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Previous research on ride-hailing has focused on the effects that the built environment, demographic variables, and personal attitudes have on the frequency of ride-hailing use, finding that adopters are mainly young and highly educated people with increased levels of technology embracement. Despite that some scholars have shown that the convenience of ride-hailing such as their flexibility and major geographical coverage has led to users to prefer services provided by Transportation Network Companies (TNCs) over public transportation for some trips, there is a lack of research on how perceptions of public transit systems and TNCs can induce ride-hailing usage. In this article we extend the understanding of ride-hailing phenomena by proposing that structural gaps in public transit are key explanatory variables in the uptake and willingness to pay for ride-hailing trips. Building on an international survey in Mexico City, Bogotá, and Medellín, we develop a Structural Equation Model (SEM) incorporating latent variables expressing perceptions people have about features of ride-hailing and vulnerabilities in public transit. Results show that these variables are relevant. We also confirm that educational attainment and income are instrumental for ride-hailing trips, and that technology embracement is the most important variable to distinguish among levels of adoption. Findings inform public policy by focusing on the negative experiences of using public transit and how this could be generating more ride-hailing trips. TNCs are an attractive transport alternative that can fill gaps in public transit systems but that are also benefiting from structural problems in the transit systems.

Suitner, Niels. Data set on the dissolution experiments available. OceanNets, March 2023. http://dx.doi.org/10.3289/oceannets_d5.1.

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Abiotic laboratory-based experiments were undertaken to determine the characteristics of mineral dissolution in seawater and thereby examine the potential for ocean alkalinization applications. As part of the mesocosm campaigns on Gran Canaria 2021 (WP5.3) and Bergen 2022 (WP5.4) we contributed to the impact assessment of OAE by conducting labbased experiments, focused on the carbonate chemistry and the stability of alkalinity in TA enhanced seawater. Due to extensive precipitation of secondary Ca-carbonates during the dissolution experiments, the focus of WP5.1 changed from mineral dissolution experiments to describing and avoiding the process of runaway precipitation while studying the generation of alkalinity. Understanding when, why and how precipitation is triggered in an OAE context might be an essential factor to determine the potential as a negative emission technology. All data sets for the dissolution experiments, the precipitation process and critical thresholds are available for project members.

Marcos Morezuelas, Paloma. Gender and Renewable Energy: Wind, Solar, Geothermal and Hydroelectric Energy. Inter-American Development Bank, November 2014. http://dx.doi.org/10.18235/0003068.

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This document focuses on how to incorporate a gender perspective in operations that support the construction, operation and maintenance of medium- and large-scale renewable wind, solar, geothermal and hydroelectric energy installations connected to the grid for purposes of power generation. Additionally, there is also a section on rural energy that is applicable to small installations and mini-grids, or to exceptional cases where medium- and large-scale facilities provide electricity to a community. The document (i) identifies the possible gender equality challenges and opportunities as part of the project assessment, (ii) highlights the risks and potentially negative impacts of the project on gender equality, (iii) offers recommendations for addressing, preventing and mitigating challenges and for maximizing opportunities; and (iv) presents examples of programs that have taken into account gender differences or risks. In addition, the document includes (v) key questions for analyzing gender issues in renewable energy projects, and (vi) examples of indicators for the monitoring and evaluation of operations in the renewable energy sector.

Levy, Alberto. What Role Can Carbon Capture Technology Play in Reducing Future CO2 Emissions? Inter-American Development Bank, November 2016. http://dx.doi.org/10.18235/0009311.

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2016 will surely be the hottest year since records began in the 19th century. The increase will be very close to the target set in the Paris Agreement to avoid an increase in global temperature by 1.5 °C. Average temperaturesin 2016 have risen to 1.2 °C above what they were before the industrial revolution. The dilemma facing the world today, in view of these data, becomes even more urgent: How to reduce greenhouse gas emissions from fossil fuels, accepting that their demand will continue to exist in the coming decades? In the energy sector, many solutions have been proposed to completely replace fossil fuels for electricity generation, such as massive deployment of renewable energy generation and increased energy efficiency. There are many restrictions, however, to achieve this result in the medium term, ranging from technological limitations in the massive deployment of energy efficiency and renewable energies, to the political economy of countries that are unlikely to reduce their oil production And carboniferous as long as demand exists. Carbon capture and storage (CCS) offers an alternative to mitigate CO2 emissions from fossil fuel power plants, considering that, given current and future energy needs, the operation of these plants will continue in the coming years. CAC could mitigate up to 90% of the carbon dioxide emitted by the use of fossil fuels in electricity generation and industrial processes. Additionally, the use of CAC with renewable biomass is one of the few carbon reduction technologies that can be used in a "carbon-negative" mode. If biomass from fuelwood crops were used, carbon could be absorbed and simultaneously generate electricity. CCS, therefore, is a viable alternative to solve the dilemma of reducing emissions while satisfying the growing energy needs of the world.

Hidalgo Pérez, Manuel, Natalia Collado Van-Baumberghen, Jorge Galindo, and Ramon Mateo Escobar. The effects of the Spanish gas cap on prices, inflation, and consumption six months later. Esade, February 2023. http://dx.doi.org/10.56269/20230202/mhp.

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The most prominent measure to moderate the escalation of electricity prices during 2022 has been the gas cap implemented exceptionally in Spain and Portugal. We present here the most accurate, rigorous and updated estimate of the effects of this measure on the regulated electricity tariff, known as the "Precio de Venta del Pequeño Consumidor (PVPC), which directly replicates the wholesale market price. To do so, we update the data we presented in September until the end of December 2022, comparing the real evolution of this tariff with a statistical model that draws the same line but in an alternative world in which the gas cap is not applied. After six months, the electricity bill at the regulated tariff in Spain is 32% cheaper than it would be in a world without the Iberian exceptionality: according to our estimate, the resulting saving for the whole of 2022 was around €209 per consumer. Moreover, inflation in 2022 would have been 0.3 points higher without a gas cap: 8.7%, instead of the 8.4% observed. In other words: half of Spain's better situation compared to the Eurozone can be attributed to this measure. On the negative side, the higher consumption of gas for electricity generation continues and the lower price of Spanish electricity, which would have facilitated the increase in exports to France with the consequent risk of subsidization in favor of French consumers at the expense of Spanish consumers.

Nguyen, Yen Thi Hai, Truc Ngoc Hoang Dang, Brian Buh, and Isabella Buber-Ennser. CORESIDING WITH PARENTS, SON PREFERENCE, AND WOMEN’S DESIRE FOR ADDITIONAL CHILDREN IN VIETNAM. Verlag der Österreichischen Akademie der Wissenschaften, September 2023. http://dx.doi.org/10.1553/0x003e7385.

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Due to strong filial piety, parents(-in-law) play an important role in their adult daughters’ fertility decisions in Vietnam; women feel pressured to fulfil their duties to produce a male descendant for the family. However, rapid urbanisation and industrialisation mean that multigenerational households are becoming less common, despite having been the standard household structure for centuries. Based on the 2020–21 Vietnam Multiple Indicator Cluster Survey, we investigate if women who coreside with the parental generation are more likely to desire additional children. In an industrialised economy, grandparents may be an important source of childcare while simultaneously exerting pressure on their adult children to have additional children. Further, we explore the association of the sex of previous child(ren) to capture the pressure associated with son preference. Multivariate regressions reveal an association between coresiding with parents and the desire for a second child, regardless of the sex of the first child. Among women with two children, third-child desires do not appear to be associated with coresiding with parents but are substantially related to having two daughters. Given the strong two-child norm in Vietnam and previous policies implying negative consequences for parents with three or more children, few women show a desire for a third child. Those women who report a desire for a third child mostly have two daughters, reflecting societal norms about the need for a male heir.