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Статті в журналах з теми "Functional integration in neuroscience"
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Shibkova, Dariya Zakharovna, and Pavel Azifovich Baiguzhin. "NEUROSCIENCE: INTERDISCIPLINARY INTEGRATION OR EXPANSION?" Психология. Психофизиология 13, no. 3 (October 21, 2020): 111–21. http://dx.doi.org/10.14529/jpps200312.
Повний текст джерелаАнотація:
Aim. The paper aims to study the differentiation and integration of scientific disciplines in the natural sciences and humanities research areas of neuroscience based on a review of Russian scientific works and to propose a structural and functional model of neuroscience as an interdisciplinary system of knowledge about brain features that ensure human activity in various professional spheres. Methods. A theoretical analysis of scientific publications on the topic over the last ten years has been used along with such methods as comparison, generalization, and modelling. Results. The paper presents various points of view on the subject field of separate disciplines within neuroscience, as well as on the relations between them. The interdisciplinarity of neuroscience is considered by a number of authors (philosophers) as a form of disciplinary colonization, epistemic expansion or intervention. Another group of authors considers neuroscience as a systemic level of science that unites multidisciplinary research activities related to the study of the brain. The third position is represented by authors who consider neuroscience as an extension of the problem field of neurobiology or as its synonym. A number of authors pay special attention to the popularity of neuroscience among politicians, military structures, pharmacological companies and other professionals with their disciplinary totality: neurophilosophy, neuropsychology, neuroinformatics, neurogenetics, neurobiology, neurosociology, neuropedagogy, etc. The paper demonstrates that there is no unified point of view on psychophysiology as a part of neuroscience, which also has interdisciplinary connections with many sciences that study individual psychological characteristics and behavior. Conclusion. Based on the analysis of the discussion, the authors emphasize the need to logically build the structural and functional relationships of individual disciplines within a unified neuroscience and determine its subject field on the basis of a systemic evolutionary approach.
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Ramsey, Richard. "Neural Integration in Body Perception." Journal of Cognitive Neuroscience 30, no. 10 (October 2018): 1442–51. http://dx.doi.org/10.1162/jocn_a_01299.
Повний текст джерелаАнотація:
The perception of other people is instrumental in guiding social interactions. For example, the appearance of the human body cues a wide range of inferences regarding sex, age, health, and personality, as well as emotional state and intentions, which influence social behavior. To date, most neuroscience research on body perception has aimed to characterize the functional contribution of segregated patches of cortex in the ventral visual stream. In light of the growing prominence of network architectures in neuroscience, the current article reviews neuroimaging studies that measure functional integration between different brain regions during body perception. The review demonstrates that body perception is not restricted to processing in the ventral visual stream but instead reflects a functional alliance between the ventral visual stream and extended neural systems associated with action perception, executive functions, and theory of mind. Overall, these findings demonstrate how body percepts are constructed through interactions in distributed brain networks and underscore that functional segregation and integration should be considered together when formulating neurocognitive theories of body perception. Insight from such an updated model of body perception generalizes to inform the organizational structure of social perception and cognition more generally and also informs disorders of body image, such as anorexia nervosa, which may rely on atypical integration of body-related information.
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Povich, Mark. "Model-based cognitive neuroscience: Multifield mechanistic integration in practice." Theory & Psychology 29, no. 5 (July 21, 2019): 640–56. http://dx.doi.org/10.1177/0959354319863880.
Повний текст джерелаАнотація:
Autonomist accounts of cognitive science suggest that cognitive model building and theory construction (can or should) proceed independently of findings in neuroscience. Common functionalist justifications of autonomy rely on there being relatively few constraints between neural structure and cognitive function. In contrast, an integrative mechanistic perspective stresses the mutual constraining of structure and function. In this article, I show how Model-Based Cognitive Neuroscience (MBCN) epitomizes the integrative mechanistic perspective and concentrates the most revolutionary elements of the cognitive neuroscience revolution. I also show how the prominent subset account of functional realization supports the integrative mechanistic perspective I take on MBCN and use it to clarify the intralevel and interlevel components of integration.
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Wrobel, Andrzej. "The need of neuroinformatic approach in functional neurophysiology." Acta Neurobiologiae Experimentalis 65, no. 4 (December 31, 2005): 421–23. http://dx.doi.org/10.55782/ane-2005-1570.
Повний текст джерелаАнотація:
Despite the enormous growth in the number of facts and regularities observed in neuroscience, the current state of the field does not allow their integration in coherent theoretical frameworks. Neuroinformatics is a new research field devoted to development of neuroscience data bases together with computational models and analytical tools for sharing, integration and analysis of experimental data and the advancement of theories of nervous system function. From 1996 the OECD countries promote fostering neuroinformatics by eliminating the barriers that prevent cooperation and by providing incentives to potential participants. This activity was formulated in the Report on Neuroinformatics from The Global Science Forum Neuroinformatics Working Group of the OECD (2002) as well as in several printed publications by the Neuroinformatics group (Amari et al. 2002, Eckersley et al. 2003). This article summarizes the ideas presented in the Report and stresses the importance of analytical and modeling approach to functional neurophysiology
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Castro, L. C. "Affective Neuroscience: A Crucial Role in Psychiatry." European Psychiatry 24, S1 (January 2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)71130-7.
Повний текст джерелаАнотація:
Background:Neuroscience has been a growing revolutionary field of scientific knowledge. The increasing recognition of the importance of emotional processes and subjective experience in several aspects of human behaviour parallel the growing amount of research in the field of affective neuroscience. Affective neuroscience studies the brain mechanisms subjacent to emotional behaviour.Aim:To discuss the relevance of affective neuroscience research in social and biological sciences, namely within psychiatric and psychological researches.Methods:Review of the literature. MEDLINE and PubMed databases searches for peer-reviewed studies, published between 1994 and 2008, using combinations of the Medline Subject Heading terms affective neuroscience, emotions, affective sciences and psychiatry, psychology, biological sciences, social sciences.Results:Several studies addresses brain functions and how emotions relate to genetics, learning, primary motivations, stress response and human behaviour. Some actual areas of research within affective neuroscience include: emotional learning, affective behaviour, emotional empathy, psychosomatic medicine, functional and structural biomarkers, emotional disorders and stress response, among others.Discussion:In Psychiatry, affective neurosciences find application in understanding the neurobiology of mood disorders, the neural control of interpersonal and social behaviour and the emotional systems that underlie psychopathology. Affective neuroscience reflects the integration of knowledge across disciplines allowing a broader understanding of human functioning. The field of affective neuroscience is an exciting field of future psychiatric research and it provides an investigational framework for studying psychiatric morbidity.
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Friston, Karl. "Functional integration and inference in the brain." Progress in Neurobiology 68, no. 2 (October 2002): 113–43. http://dx.doi.org/10.1016/s0301-0082(02)00076-x.
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Krebs, H. I., T. Brashers-Krug, S. L. Rauch, C. R. Savage, N. Hogan, R. H. Rubin, A. J. Fischman, and N. M. Alpert. "Integration of robotic technology with functional imaging." NeuroImage 3, no. 3 (June 1996): S394. http://dx.doi.org/10.1016/s1053-8119(96)80396-x.
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Arachchige, Arosh S. Perera Molligoda. "Transitioning from PET/MR to trimodal neuroimaging: why not cover the temporal dimension with EEG?" AIMS Neuroscience 10, no. 1 (2023): 1–4. http://dx.doi.org/10.3934/neuroscience.2023001.
Повний текст джерелаАнотація:
<abstract> <p>The possibility of multimodality imaging with PET/MR and the availability of ultra-high field MRI has allowed to investigate novel aspects of neuropsychiatric conditions. One of the major barriers in current studies is the lack of an instrument that allows to accurately cover the temporal aspect under the same physiological conditions. The aim of this commentary is to provide our perspective on how the integration of EEG-PET-MR could be a solution to the current challenge in molecular imaging and seems to hold great promise in future pharmacological challenging-based studies, understanding different functional states of the brain, and could furthermore aid in the diagnostic and prognostic evaluations of neurocognitive disorders.</p> </abstract>
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Parlatini, Valeria, Joaquim Radua, Flavio Dell’Acqua, Anoushka Leslie, Andy Simmons, Declan G. Murphy, Marco Catani, and Michel Thiebaut de Schotten. "Functional segregation and integration within fronto-parietal networks." NeuroImage 146 (February 2017): 367–75. http://dx.doi.org/10.1016/j.neuroimage.2016.08.031.
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Aydarkin, Evgeny K., and Marina A. Pavlovskaya. "Functional hemisphere asymmetry and sensorimotor integration." International Journal of Psychophysiology 77, no. 3 (September 2010): 327. http://dx.doi.org/10.1016/j.ijpsycho.2010.06.254.
Повний текст джерелаДисертації з теми "Functional integration in neuroscience"
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Abbatecola, Clement. "Behavioral and functional imaging analyses of face and voice integration in gender perception." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1289.
Повний текст джерелаАнотація:
Cette thèse décrit l'intégration multimodale voix-visage pour la perception du genre à l'aide de méthodes comportementales et d'imagerie cérébrale. Dans une première étude psychophysique, les observateurs ont départagé des paires de stimuli voix-visage selon le genre du visage, de la voix ou du stimulus (sans instruction particulière). Une seconde étude a reproduit ce paradigme en ajoutant du bruit visuel et/ou auditif. Conformément à nos résultats théoriques, tâche et bruit peuvent tous deux être modélisés comme des facteurs de pondération. Les deux effets pourraient refléter des changements similaires de hiérarchie fonctionnelle avec la communication par cohérence comme implémentation potentielle de ce mécanisme en termes de modulation sélective de l'information par synchronisation des rythmes d'oscillation neuronaux. Une asymétrie en faveur de la modalité auditive a été trouvée dans les deux études comportementales ainsi que deux interactions : un effet multiplicatif du genre significatif lorsqu'on juge le visage et le stimulus ; un effet de cohérence significatif lorsqu'on juge le visage ou la voix. Une troisième étude en IRMf s'est intéressée aux modulations de connectivité effective entre l'aire fusiforme du visage et l'aire temporale de la voix durant la présentation de stimuli voix-visage en prêtant attention au genre du visage, de la voix ou du stimulus. Une telle modulation a été trouvée dans les tâches du visage et du stimulus en réponse au genre, et dans les tâches du visage et du stimulus en réponse à l'incohérence, deux modulations indépendantes qui pourraient être supportées par l’architecture anatomique en double contre-courantThis thesis describes face-voice multimodal gender integration using complementary behavioral and brain imaging techniques. In a first psychophysical study, observers judged pairs of face-voice stimuli according to face, voice or stimulus (no specific instruction given) gender. A second study tested the bottom-up effect of adding visual and/or auditory noise in the same paradigm. Top-down task and bottom-up noise could both be modeled as weighting effects, as predicted by our theoretical results. Both effects might reflect similar shifts in functional hierarchy. Communication through coherence offers a potential explanation for the neural basis of such a mechanism in terms of selective modulation of segregated cortical streams by oscillatory rhythm synchronization. An asymmetry in favor of the auditory modality was found in both behavioral experiments as well as two interaction effects, first a multiplicative gender effect in the face and stimulus tasks, second an effect of gender coherence in the face and voice tasks. In a third experiment we used fMRI to investigate effective connectivity modulations between the Fusiform Face Area and Temporal Voice Area during the presentation of face-voice stimuli while attending to either face, voice or any gender information. We found a change in effective connectivity for stimulus and face tasks in response to gender information, and for face and voice tasks in response to gender incoherence. These two independent modulations could be supported by the anatomical dual counterstream architecture
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Bell, Joseph Sumner. "Non-Linear Stimulus Integration in Olfactory Computation." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467331.
Повний текст джерелаАнотація:
All animals must use patterns of olfactory receptor neuron (ORN) activity to compute appropriate behavioral responses to odors, but the form of this computation is unknown. In both flies and mammals, each ORN expresses one type of odorant receptor that determines its odor response profile, and all ORNs expressing the same receptor project to the same compartment in the brain, or glomerulus. These glomeruli constitute parallel processing channels that relay olfactory information to other areas, and are often co-activated by odors. One popular hypothesis holds that activity in each glomerulus contributes to a central representation of valence, or pleasantness, by a fixed linear weight. Alternatively, non-linear interactions between specific glomeruli could confer increased selectivity or sensitivity for ethologically important odors. We investigate these alternative models by optogenetically activating olfactory glomeruli in freely walking Drosophila, and use video tracking to analyze the behavioral responses of thousands of individual flies. Flies respond to optogenetic fictive odors, but require wind to orient their walking responses. Some glomeruli produce robust attraction when activated individually. Combining stimulation of pairs of glomeruli produces unpredictable results: some pairs sum to produce attraction greater than that elicited by either component, but others produce the same behavior as the more attractive component alone. Surprisingly, we find no reliably repulsive glomeruli, but some potently reduce attraction in combinations. Based on which glomeruli summate, we develop a simple model that establishes a lower bound on the dimensionality of internal olfactory representations. Although we provide evidence that the brain combines signals from glomeruli using several pools with overlapping but distinct sets of inputs, detailed computational analysis of walking trajectories suggests that flies respond to these stimuli by graded recruitment of a single behavioral program.Medical Sciences
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Knutson, Keith. "Britain's functional approach to integration /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9988679.
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Chong, Man-Tze Mabel. "Development of sensorimotor integration and modulation in zebrafish." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18784.
Повний текст джерелаАнотація:
Neural control of behaviour during development is a complicated orchestration of gene expression, neuronal differentiation, axonal projection, modification of intrinsic membrane properties and connectivity of neural circuits. The studies in this thesis combined genetic, molecular, and physiological assays to investigate neuromodulation, reticulospinal contribution, and neurogenic programming of the limited behavioural repertoire of developing zebrafish. Maturation of early swimming, the change from infrequent episodes of swim bursts to a sustained “beat-and-glide” pattern, was mediated by serotonergic modulation of the spinal network. Serotonergic immunoreactivity was first detected in neurons located in the ventral spinal cord at 2 days post-fertilization (dpf). A second population of serotonergic neurons was detected in the hindbrain but these remained isolated from the spinal cord in the stages studied (2-4 dpf). Serotonergic modulation of the fictive swim pattern only occurred in 4 dpf larvae, the time when “beat-and-glide” swimming emerges, but not in younger larvae. Application of serotonin did not affect properties of activity (beat-and-glide) periods, but instead reduced the periods of inactivity between activity periods. Hindbrain reticulospinal (RS) neurons displayed four types of activity patterns during simultaneous spinal motoneuron recordings of fictive swimming activity in zebrafish larvae. RS neurons generated these activity patterns even in the absence of ascending spinal input during development. The spinal CPG network, however, failed to produce rhythmic oscillations in the presence of N-methly-d-aspartate when it developed without descending RS input, indicating that the latter are necessary for development of CPG activity. In addition to swimming, zebrafish larvae also produce startle responses in reaction to potential danger, a behaviour that is missing in hi472 mutant larvae. hi472 mutation disruptLe contrôle neuronal du comportement durant le développement dépend de l'intégration complexe de l'expression génétique, de la différentiation neuronale, de la projection axonale, de la modification des propriétés membranaires intrinsèques et de la connectivité des circuits neuronaux. Les études décrites dans cette thèse regroupent des approches génétiques, moléculaires et physiologiques afin d'examiner la neuromodulation, la contribution du système réticulospinal et la programmation neurogène afin d'étudier le répertoire limité des comportements du poisson zébré en voie de développement. Vers la quatrième journée du développement les larves changent leur comportement de natation, ils passent d'épisodes rares et de courte durée de natation en un patron maintenu de type nage-et-glisse, ou le poisson exécute quelques fortes contractions de la queue suive d'une période de glisse. Nous avons démontré cette maturation de la natation précoce, est due à la modulation sérotoninergique du réseau spinal. L'immunoréactivité sérotoninergique est détectée initialement chez une population de neurones situés dans la moelle épinière ventrale à 2 jours post-fertilisation (jpf). Une deuxième population de neurones sérotoninergiques a été détectée dans le tronc cérébral mais celle-ci ne projette pas d'axones vers la moelle épinière aux stades étudiés (2-4 jpf). La modulation sérotoninergique du patron de natation fictive se manifeste seulement chez des alevins de 4 jpf, au moment ou la natation nage-et-glisse se déploie, mais pas chez des alevins plus jeunes. Nous avons aussi démontré que l'application de sérotonine n'a aucun effet sur les propriétés des épisodes de nage active mais par contre, résulte en une réduction de la durée périodes d'inactivité entre les épisodes de nage-et glisse. Les neurones réticulospinaux (RS) du tronc cérébral manifestent quatre types de patron d'acti
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Tuason, Maria Clarita. "Functional analysis of Proteolipid Protein regulatory sequence." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101805.
Повний текст джерелаАнотація:
Myelin is an evolutionarily late acquisition of the vertebrate nervous system which speeds electrochemical signaling in mature nerve fibers by providing insulation in the form of a lipid-rich multilammelar sheath. Proteolipid Protein (PLP) is the most abundant protein in mature mammalian central nervous system myelin where it serves as a structural component in addition to other yet undefined roles. It is coordinately regulated at the transcriptional level with other myelin genes such as Myelin Basic Protein (MBP). The major components of MBP transcriptional regulation have been defined using a strategy of targeted transgenesis at the hypoxanthine phosphoribosyl transferase (HPRT) locus allowing quantitative and qualitative in vivo analysis of the transcriptional control exerted by conserved non-protein-coding sequences in transgenic mice. This study describes the localization and functional characterization of PLP conserved non-protein-coding sequences. Conservation was surveyed using alignments of genome sequences for a number of vertebrates ranging in their evolutionary distance from mouse. Aligned sequences were also scanned for clusters of conserved consensus binding sites for sox 10, krox20, gtx and betaHLH transcription factors, which play key roles in nervous system development. Dissection of conserved non-protein-coding sequence resulted in the production of a series of 10 reporter constructs addressing the search for PLP regulatory elements. This series includes highly conserved regions, some of which contain clusters of transcription factor consensus sites, as well as lesser conserved regions which were suggested to have regulatory activity in previous investigations. Notably, in vivo evidence of the importance of intron 1 for expression in the nervous system led to subsequent deletion-transfection analyses revealing a seemingly potent enhancer, the antisilencer/enhancer (ASE) within the intron, which is functionally validated in this study. Of this series, 8 of the selected regions have been amplified successfully and cloned into HPRT targeting constructs with a minimal lisp promoter and LacZ reporter. All 8 constructs have been transfected into ES cells. Homologous recombinants with the transgene docked at HPRT were selected, and chimeras have been analyzed for 3 of these constructs. To our surprise, neither a construct containing 2kb of 5' flanking sequence, nor a construct containing the highly conserved intron 3, were able to drive expression at the peak of myelination. A construct containing the ASE was unexpectedly shown to drive expression in cells scattered within the central grey matter of the spinal cord in a pattern intriguingly similar to that seen embryonically from migrating oligodendrocyte progenitors. The lack of expression of the first 2 constructs suggests that PLP regulatory elements may be interdependent, but we anticipate that delivery into germline followed by developmental and analysis of the full series of constructs will bring light to the emerging picture of partnerships between regulatory elements, and will also reveal the identity of the cells driving expression from the ASE. Understanding PLP transcriptional control may lead to therapeutic interventions as associated diseases result predominantly from imbalances in gene dosage leading to abnormal levels of PLP protein.
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Bélanger, Danny. "Heterologous functional interactions of P2X ATP receptors." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81596.
Повний текст джерелаАнотація:
Part I. In this work we show that P2X3 currents are acutely modulated by the GPCRs mGluR5 and P2Y2, and by the neurotrophin TrkA receptor, expressed in nociceptors, in the recombinant Xenopus oocyte system. The intracellular C-terminal domain of P2X 3 plays an important role in its functional coupling to TrkA. Preliminary studies suggest a role for PKC in the P2X3-TrkA cross-talk, but other routes may also contribute. Part II. Neurogenic and pharmacological stimulation of vascular smooth muscle P2X1 elicits a contractile response that we found was potentiated by serotonin acting through 5HT2A. We also found in Xenopus oocytes that P2X 1 currents in the desensitized state are potentiated by M1 ACh receptors and by phorbol ester stimulation of PKC. Part III. We have shown in Boue-Grabot et al. (2003) that there was an intracellular negative cross-talk and physical interaction between P2X2 and 5HT3A receptors. We also found a functional interaction between P2X2 and GABAA alpha2beta 3 receptor subtypes in HEK293 mammalian cells and in Xenopus oocytes; and we confirmed the findings of Sokolova et al. , (2001) in primary cultures of DRG neurons. (Abstract shortened by UMI.)
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Wilson, Jennifer M. M. "Mechanisms of neuronal integration in adrenomedullary sympathetic preganglionic neurons." Thesis, University of Ottawa (Canada), 2002. http://hdl.handle.net/10393/6334.
Повний текст джерелаАнотація:
Sympathetic preganglionic neurons innervating the adrenal medulla (AD-SPN) regulate the release of adrenal catecholamines into the bloodstream. This research was undertaken to investigate the intrinsic properties and synaptic pathways characteristic of AD-SPN in neonatal rat spinal cord slice preparation. The presence of Lucifer Yellow from the patch pipette and Rhodamine-Dextran-Lysine from the adrenal medulla in the same neuron post recording identified AD-SPN. Active intrinsic properties revealed and characterised include: a potassium-mediated transient outward rectification present in 96% of AD-SPN and separable into a short 4-aminopyridine- and a long barium-sensitive component; a potassium-mediated sustained outward rectification revealed in TTx, activated positive to -50mV and blocked with quinine. These conductances contribute to the repolarising phase of the action potential. 89% of AD-SPN possessed potassium-mediated anomalous inward rectification. All AD-SPN displayed a high voltage-activated calcium spike that prolongs the action potential. The addition of internal caesium (140mM) revealed a low threshold spike mediated by T-type calcium channels that serve to facilitate burst firing. 75% of AD-SPN exhibited evidence of electrotonic coupling, indicated by characteristic oscillations in membrane potential and confirmed with dual recordings from electrotonically coupled AD-SPN. Electrotonic coupling promoted synchronous activity. An enhanced afterhyperpolarising potential facilitated transient termination of action potential firing forming bursts of activity. A role for calcium in the regulation of neuronal activity via action on electrotonic coupling was suggested by caffeine (10mM) decreasing, BAPTA-AM (15muM) and calcium free aCSF increasing the junctional conductance. Electrical stimulation of the descending fibres in both the ipsi- and contralateral funiculi evoked fast EPSPs in all AD-SPN that were mediated by both NMDA and non-NMDA receptors. A subpopulation of AD-SPN received fast IPSPs mediated by GABA acting via GABAA receptors. A train of stimuli (4 x 10Hz) in ipsi- and contralateral funiculi also evoked a slow IPSP mediated by noradrenaline acting via alpha 2-adrenergic receptors to increase a potassium conductance. The results provide insight into central mechanisms that contribute to the regulation of adrenomedullary catecholamine secretion.
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Tahvildari, Babak. "Functional organization of the perirhinal-lateral entorhinal circuit." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103185.
Повний текст джерелаАнотація:
The perirhinal cortex (PRC) and the lateral entorhinal cortex (LEC) are essential components of the medial temporal lobe memory system, but the functional organization and interconnectivity of these structures is poorly defined. In this thesis, novel in-vitro and in-vivo approaches were developed to investigate the synaptic organization, intrinsic properties and cholinergic modulation of neurons in the PRC and LEC. In-vivo and in-vitro field potential profiles, combined with current-source density analysis and in-vitro intracellular recordings, demonstrated the existence of bi-directional excitatory synaptic interactions between the PRC and the LEC. Intracellular recordings and dye injection were also used to perform a morphological and electrophysiological characterization of principal neurons located in layers II and III of the LEC. These studies revealed that principal neurons in layer II of the LEC possess more heterogeneous morphological and electrophysiological properties than those in layer III. Moreover, layer III principal neurons display extensively arborized basal and apical dendrites that extend into layers I, II, III and V. This widespread arborization may allow these neurons to integrate neural signals destined for, and coming from, the hippocampus. We also discovered that muscarinic cholinergic receptor activation allows principal neurons in layer III of the LEC to generate persistent activity at a fixed frequency following an excitatory stimulus. This activity can be terminated by the application of another excitatory stimulus, allowing the cells to toggle between "On" and "Off" states. Finally, pharmacological and ionic substitution experiments in-vitro established that the "On" and "Off" states of these cells are respectively dependent on Ca 2+-dependent non-specific channels, and BK-type Ca2+-dependent K+ channels. These studies expand our understanding of the network and cellular mechanisms by which neurons in the PRC and LEC may contribute to long-term and short term memory.
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Bernier, Louis-Philippe. "Functional regulation of P2X receptor channels by phosphoinositides." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110361.
Повний текст джерелаАнотація:
Long after its initial discovery as part of DNA and as the main source of energy in the cell, the nucleotide adenosine-5'-triphosphate (ATP) is now rightfully considered as an important extracellular signalling molecule. It is now known that purinergic transmission plays significant physiological roles, notably in neuro- and gliotransmission, in the modulation of the innate and adaptive immune response, in smooth muscle constriction and in regulating blood clotting. It is also actively involved in the generation and maintenance of various pathological states, including chronic neuropathic and inflammatory pain.How purinergic signalling can be implicated in such a diverse array of mechanisms via only one signalling molecule comes from the variety of receptors that are activated by ATP. Two major types of ATP-sensitive receptors exist: the P2X ionotropic receptor channels and the metabotropic P2Y receptors. The P2X family of ATP-gated ion channels is composed of seven subunits that assemble as trimers to form receptors with various functional and pharmacological profiles. Like all ion channels, the activity of P2X receptor channels is tightly regulated by orthosteric and allosteric regulation mechanisms. This thesis provides evidence of a novel type of post-translational regulation mechanism where the levels of intracellular phosphoinositides (PIPn) modulate the channel activity of P2X receptors. The first article included in my thesis focuses on the P2X1 subtype, which is mainly involved in smooth muscle constriction in blood vessels and vas deferens, as well as in the control of platelet aggregation and blood clotting. We demonstrate that the activity of the P2X1 receptor channel is positively regulated by membrane PI(4,5)P2 (PIP2). Depleting the intracellular levels of PIP2 decreased the ATP-activated current carried through the P2X1 channel and had an inhibitory effect on ATP-mediated mesenteric artery constriction, a P2X1-dependent process. Direct binding between the P2X1 cytosolic tail and PIP2 is shown to be necessary for the full expression of P2X1 activity.The next article in this thesis describes the PIPn-dependent regulation of the P2X4 receptor channel, which is highly involved in the generation of neuropathic and inflammatory pain through its expression in spinal cord microglia. Results obtained show that complete P2X4 function is dependent on the levels of PIP2 and PI(3,4,5)P3 (PIP3). Both species of phospholipids potentiate the P2X4-mediated ionic current and calcium entry by directly binding to the C-terminal domain of P2X4 subunits. Activation of co-expressed microglial metabotropic receptors can trigger changes in PIP2 or PIP3 levels, which could affect the contribution of P2X4 in pain-inducing mechanisms.In the third report, we investigate the molecular characteristics of the interaction between membrane PIPn and the various P2X receptors that were shown to be directly modulated by the phospholipids. By analyzing the functional and PIPn-binding effects of various mutations performed on the C-terminal domain of the PIPn-sensitive P2X1, P2X4 and P2X7 subtypes as well as on the PIPn-insensitive P2X5 subtype, we identify the PIPn-binding regulatory motif of P2X receptors. The last article included in this thesis examines the dynamic changes in channel permeability brought by sustained activation of the microglial P2X4 receptor. We show that upon sustained ATP application, P2X4 channels form large conductance pores allowing the flux of large organic molecules. The large pore formation of co-expressed microglial P2X7 receptors has been extensively studied; we show here that P2X4-mediated permeation is mechanistically distinct and, in contrast with P2X7, does not induce membrane blebbing or cell death. Furthermore, we demonstrate that membrane PIPn potentiate the formation of this high-conductance P2X4 pore, suggesting that this property can be regulated by metabotropic changes in PIPn levels.Longtemps après la découverte de sa présence dans l'ADN et de son rôle en tant que principale source d'énergie chimique dans la cellule, le nucléotide adenosine-5'-triphosphate (ATP) est maintenant considéré comme une importante molécule de signalisation extracellulaire. La transmission purinergique est activement impliquée dans plusieurs processus physiologiques, notamment dans la neuro- et glio-transmission, la modulation de la réponse immunitaire innée et adaptative, la constriction vasculaire et la coagulation sanguine. Elle participe aussi à la génération et au maintien de divers états pathologiques, tels la douleur chronique neuropathique et inflammatoire.La signalisation purinergique est impliquée dans des processus aussi diversifiés par l'entremise d'une seule molécule de signalisation grâce à une grande variété de récepteurs activés par l'ATP. Les deux principaux types de récepteurs sensibles à l'ATP sont les récepteurs ionotropiques P2X et les récepteurs métabotropiques P2Y. La famille P2X de canaux ioniques activés par l'ATP est composée de sept sous-unités qui s'assemblent comme trimères pour former des récepteurs possédant divers profils fonctionnels et pharmacologiques. Comme tous les canaux ioniques, l'activité des P2X est étroitement régulée par des mécanismes de régulation orthostériques et allostériques. Cette thèse démontre l'existence d'un nouveau type de mécanisme de régulation post-traductionnel, où les niveaux de phosphoinositides (PIPn) intracellulaires modulent l'activité de canal ionique des récepteurs P2X.Le premier article porte sur le sous-type P2X1, qui contribue à la contraction des muscles lisses dans les vaisseaux sanguins et le canal déférent, ainsi qu'à l'agrégation plaquettaire. Nous démontrons que l'activité du récepteur canal P2X1 est positivement régulée par les PI(4,5)P2 (PIP2) membranaires. La déplétion des niveaux intracellulaires de PIP2 diminue l'amplitude du courant ionique induit par P2X1. Nous montrons que le couplage direct entre le domaine C-terminal cytosolique de P2X1 et PIP2 est nécéssaire pour l'expression complète de l'activité de P2X1.Le second article de cette thèse décrit la régulation PIPn-dépendante du récepteur canal P2X4, qui joue un rôle majeur dans la génération et le maintien de la douleur neuropathique et inflammatoire par son expression dans les microglies de la moelle épinière. Nous démontrons que le fonctionnement de P2X4 dépend des niveaux de PIP2 et de PI(3,4,5)P3 (PIP3). Les deux types de phospholipides potentialisent le courant ionique ainsi que l'entrée de calcium par le canal P2X4 en se liant directement au domaine C-terminal des sous-unités P2X4. Dans le troisième rapport, nous étudions les caractéristiques moléculaires de l'interaction entre les PIPn membranaires et les récepteurs P2X directement modulés par ces phospholipides. En analysant les effets fonctionnels de diverses mutations effectuées sur le domaine C-terminal des sous-types PIPn-dépendant P2X1, P2X4 et P2X7 et sur le sous-type PIPn-indépendant P2X5, nous identifions le motif nécessaire à la liaison P2X-PIPn et à la régulation fonctionnelle du canal par les PIPn.Le dernier article de cette thèse examine les changements dynamiques de la perméabilité du canal ionique apportés par une activation soutenue des récepteurs microgliaux P2X4. Nous montrons que, lors d'une application soutenue d'ATP, les canaux P2X4 forment des pores à haute conductance permettant le flux de molécules organiques à haut poids moléculaire. La formation de larges pores par les récepteurs P2X7 a été étudiée intensivement; nous démontrons ici que la perméation induite par P2X4 est mécanistiquement distincte et, à l'opposé de P2X7, ne mène à aucun réarrangement de la structure membranaire ni à la mort cellulaire. Les PIPn membranaires potentialisent la formation de ces pores à haute conductance par P2X4, suggérant que cette propriété peut être régulée par des changements intracellulaires des niveaux de PIPn.
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Foster, Nicholas Elgin. "Structural and functional correlates of mental musical transformation." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96781.
Повний текст джерелаАнотація:
Music represents both a ubiquitous element in human cultures and a highly complex discipline to which some individuals devote decades of practice. Music is therefore an ideal medium with which to probe human auditory perception over a wide range of skill. Differences in brain structure and function have been reported in musicians (vs. untrained individuals), but because of methodological limitations, the links bringing together behavior, structure and function have remained indirect. This thesis consists of three neuroimaging studies that, together, elucidate some of the functional and anatomical substrates of aspects of melodic perception. Study 1 used functional magnetic resonance imaging (fMRI) and a mental pitch transposition task to localize cortical activity related to mental manipulation of melodic sequences; the results showed that recruitment of the intraparietal sulcus (IPS) is specifically related to successful mental transposition. Study 2 employed fMRI to test two follow-up questions: whether the same subregion of IPS is also involved in temporal manipulation of melodies, and whether transposition to more distant keys evokes greater activation in IPS. The results showed that in individual subjects, a common area of IPS subserves mental melodic transformations in both pitch-based and time-based reference frames, and that the magnitude of IPS activation is associated with the magnitude of the transformation required. Study 3 tested for anatomical correlates of mental pitch transposition ability, and found that both gray matter concentration and thickness in auditory cortex and IPS predict performance on this task. The structural effects in IPS were in close spatial correspondence with the functional effects in Studies 1 and 2. Although structural and functional effects showed positive correlations with musical experience, there was also evidence for a training-independent correlation between mental transposition ability and IPS structure/function, supporting the idea that pre-existing behaviorally relevant variation is further modified by training. These studies therefore provide convergent structural and functional evidence of a specific role for the IPS in a complex aspect of musical perception. The results are in agreement with models of dorsal sensory processing that emphasize abstract non-spatial computations, and advance the idea that posterior parietal cortex is important for systematic musical transformations.La musique représente à la fois un élément omniprésent dans la culture humaine et une discipline très complexe dans laquelle certaines personnes consacrent des décennies de pratique. La musique est ainsi un moyen idéal pour sonder la perception auditive humaine sur un large éventail de compétences. Les différences dans la structure et la fonction du cerveau ont été rapportées chez des musiciens (vs. individus non entraînés), mais en raison de limites méthodologiques, les liens réunissant les comportements, la structure et la fonction sont restés indirects. Cette thèse consiste en trois études en neuroimagerie qui ensemble, élucident quelques substrats anatomiques et fonctionnels des aspects de la perception mélodique. L'étude 1 utilise l'imagerie par résonance magnétique fonctionnelle (IRMf) et une tâche de transposition mentale de la hauteur des notes pour localiser l'activité corticale liée à la manipulation mentale de séquences mélodiques; les résultats ont montré que le recrutement du sulcus intrapariétal (SIP) est relié spécifiquement à la réussite d'une transposition mentale. L'étude 2 a utilisé l'IRMf pour répondre aux deux questions suivantes, à savoir si la même sous-région du SIP est également impliquée dans la manipulation temporelle des mélodies, et si la transposition de notes plus distantes évoque une plus grande activation dans le SIP. Les résultats ont montré que chez des sujets individuels, une aire commune dans le SIP favorise les transformations mélodiques mentales à la fois basées sur la hauteur des notes et sur des cadres de référence basés sur le temps, et que la magnitude de l'activation dans le SIP est associée avec la magnitude des transformations requises. L'étude 3 a testé les corrélats anatomiques de la capacité de transposition mentale de la hauteur des notes, et a montré qu'à la fois la concentration de matière grise et l'épaisseur dans le cortex auditif et dans le SIP prédit la performance à la tâche. Les effets structuraux dans le SIP étaient en étroite correspondance spatiale avec les effets fonctionnels dans les études 1 et 2. Bien que les effets anatomiques et fonctionnels aient montré des corrélations positives avec l'expérience musicale, il y avait aussi la preuve d'une corrélation entre la capacité de transposition mentale et la structure/fonction dans le SIP, indépendante de l'entraînement, appuyant l'idée qu'une variation comportementale préexistante est en outre modifiée par l'entraînement. Ces études sont par conséquent des preuves structurelles et fonctionnelles convergentes pour un rôle spécifique du SIP dans un aspect complexe de la perception musicale. Les résultats sont en accord avec les modèles du traitement sensoriel dorsal qui mettent l'accent sur des traitements non-spatiaux abstraits, et renforcent l'idée que le cortex pariétal postérieur est important pour des transformations musicales systématiques.
Книги з теми "Functional integration in neuroscience"
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Feifer, Steven G. Integrating RTI with cognitive neuropsychology: A scientific approach to reading. Middletown, MD: School Neuropsych Press, 2007.
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Steward, Oswald. Functional Neuroscience. New York, NY: Springer New York, 2000. http://dx.doi.org/10.1007/978-1-4612-1198-3.
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Colin, Barber, and International Evoked Potentials Symposium (6th : 1996? : Milan, Italy), eds. Functional neuroscience. Amsterdam: Elsevier, 1996.
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DeWitt-Morette, Cecile, Pierre Cartier, and Antoine Folacci, eds. Functional Integration. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4899-0319-8.
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Bichteler, Klaus. Integration - A Functional Approach. Basel: Springer Basel, 1998. http://dx.doi.org/10.1007/978-3-0348-0055-6.
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Afifi, Adel K. Basic neuroscience: A structuraland functional approach. 2nd ed. Baltimore: Urban & Schwarzenberg, 1985.
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1951-, Pincus Harold Alan, Pardes Herbert 1934-, and American Psychiatric Association Meeting, eds. The Integration of neuroscience and psychiatry. Washington, D.C: American Psychiatric Press, 1985.
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Cécile, DeWitt-Morette, Cartier P, Folacci Antoine, North Atlantic Treaty Organization. Scientific Affairs Division., and NATO Advanced Study Institute on Functional Integration: Basics and Applications (1996 : Cargèse, France), eds. Functional integration: Basics and applications. New York: Plenum Press, 1997.
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Cécile, DeWitt-Morette, ed. Functional integration: Action and symmetries. Cambridge, UK: Cambridge University Press, 2006.
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1927-, Bergman Ronald A., ed. Basic neuroscience: A structural and functional approach. 2nd ed. Baltimore: Urban & Schwarzenberg, 1986.
Знайти повний текст джерелаЧастини книг з теми "Functional integration in neuroscience"
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Steward, Oswald. "Neuronal Integration." In Functional Neuroscience, 145–56. New York, NY: Springer New York, 2000. http://dx.doi.org/10.1007/978-1-4612-1198-3_8.
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Christov-Moore, Leonardo, Dimitris Bolis, Jonas Kaplan, Leonhard Schilbach, and Marco Iacoboni. "Trust in Social Interaction: From Dyads to Civilizations." In Social and Affective Neuroscience of Everyday Human Interaction, 119–41. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08651-9_8.
Повний текст джерелаАнотація:
AbstractHuman trust can be construed as a heuristic wager on the predictability and benevolence of others, within a compatible worldview. A leap of faith across gaps in information. Generally, we posit that trust constitutes a functional bridge between individual and group homeostasis, by helping minimize energy consumed in continuously monitoring the behavior of others and verifying their assertions, thus reducing group complexity and facilitating coordination. Indeed, we argue that trust is crucial to the formation and maintenance of collective entities. However, the wager that trust represents in the face of uncertainty leaves the possibility of misallocated trust, which can result in maladaptive outcomes for both individuals and groups. More specifically, trust can be thought of as a scale-invariant property of minimizing prediction error within ascending levels of social hierarchy ranging from individual brains to dyads, groups and societies, and ultimately civilizations. This framework permits us to examine trust from multiple perspectives at once, relating homeostasis, subjective affect and predictive processing/active inference at the individual level, with complexity and homeostasis at the collective level. We propose trust as a paradigmatic instance of an intrinsically dialectical phenomenon bridging individual and collective levels of organization, one that can be observed in daily experience and empirically studied in the real world. Here, we suggest collective psychophysiology as a promising paradigm for studying the multiscale dynamics of trust. We conclude with discussing how our integrative approach could help shine light on not only the bright but also the dark sides of trust.
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Steward, Oswald. "Ground Plan of the Nervous System I." In Functional Neuroscience, 3–23. New York, NY: Springer New York, 2000. http://dx.doi.org/10.1007/978-1-4612-1198-3_1.
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Steward, Oswald. "Somatic Sensation II." In Functional Neuroscience, 175–93. New York, NY: Springer New York, 2000. http://dx.doi.org/10.1007/978-1-4612-1198-3_10.
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Steward, Oswald. "Somatic Sensation III." In Functional Neuroscience, 195–209. New York, NY: Springer New York, 2000. http://dx.doi.org/10.1007/978-1-4612-1198-3_11.
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Steward, Oswald. "Somatic Sensation IV." In Functional Neuroscience, 211–21. New York, NY: Springer New York, 2000. http://dx.doi.org/10.1007/978-1-4612-1198-3_12.
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Steward, Oswald. "Motor System I." In Functional Neuroscience, 227–38. New York, NY: Springer New York, 2000. http://dx.doi.org/10.1007/978-1-4612-1198-3_13.
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Steward, Oswald. "Motor System II." In Functional Neuroscience, 239–55. New York, NY: Springer New York, 2000. http://dx.doi.org/10.1007/978-1-4612-1198-3_14.
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Steward, Oswald. "Motor System III." In Functional Neuroscience, 257–71. New York, NY: Springer New York, 2000. http://dx.doi.org/10.1007/978-1-4612-1198-3_15.
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Steward, Oswald. "The Basal Ganglia." In Functional Neuroscience, 273–87. New York, NY: Springer New York, 2000. http://dx.doi.org/10.1007/978-1-4612-1198-3_16.
Повний текст джерелаТези доповідей конференцій з теми "Functional integration in neuroscience"
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Bazanova, Olga, Anastasia Kovaleva, Tatiana Petrenko, and Anna Gorbacheva. "SENSORIMOTOR INTEGRATION TRAINING DEVELOPMENT FOR OPTIMIZATION OF FUNCTIONAL STATE IN ADULTS." In XVII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2021. http://dx.doi.org/10.29003/m2047.sudak.ns2021-17/71-72.
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LABUTIN, I. A., and S. I. CHUPRINA. "A USER-FRIENDLY ONTOLOGY-DRIVEN NEUROINTERFACE INTEGRATION TOOLSET." In GRAPHICON 2024, 428–37. Omsk State Technicl University, 2024. http://dx.doi.org/10.25206/978-5-8149-3873-2-2024-428-437.
Повний текст джерелаАнотація:
Recently, there has been a remarkable increase in enthusiasm for utilizing neurocomputer interfaces to develop control systems, particularly within the context of various Internet of Things (IoT) ecosystems. Despite this growing interest, integrating these low-level devices and their functional tools with diverse IoT infrastructure components poses significant hurdles. Achieving successful integration demands a deep understanding of both neuroscience and signal processing. To address these complexities, we propose an innovative, ontology-driven framework designed to enable the effortless incorporation of brain-computer interfaces (BCI) into varying IoT environments. By harnessing the principles of ontology engineering, our high-level approach equips researchers and engineers-with varying levels of BCI experience-to automate the integration between neurocomputer interfaces and multiple IoT infrastructures seamlessly. In this paper, we will detail several advancements made to our previous implementation of this strategy. Notable enhancements include the development of an intuitive graphical user interface and the introduction of a new data processing pipeline that utilizes a portable device to validate the effectiveness of our system.
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Filatova, Yulia, and Lidia Belyakova. "INTEGRATION OF PSYCHOMOTOR FUNCTIONS IN THE PROCESS OF CHILD’S SPEECH-MOTOR STEREOTYPE DEVELOPMENT." In XVI International interdisciplinary congress "Neuroscience for Medicine and Psychology". LLC MAKS Press, 2020. http://dx.doi.org/10.29003/m1304.sudak.ns2020-16/479-480.
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Lazarus, Gershom T., and Christine L. Ginalis. "Applying principles of Luria’s theory to the fetal stage and integration of psycho-physiological mechanisms to optimize adaptive behavior." In 2nd International Neuropsychological Summer School named after A. R. Luria “The World After the Pandemic: Challenges and Prospects for Neuroscience”. Ural University Press, 2020. http://dx.doi.org/10.15826/b978-5-7996-3073-7.4.
Повний текст джерелаАнотація:
Luria proposed that the brain is organized hierarchically and according to functional units. The functional units provide a basis of integrated experience and behavior that becomes fractionated in various psychological and behavioral disorders. Emerging research suggests that the fundamental organization of brain networks and functional connections are established in utero during the second and third trimesters of fetal development. This paper discusses the value of studying emerging fetal organization within the framework of Luria’s theory. In addition, it will expand Luria’s theory in emphasizing the integration of physiological and psychological mechanisms across the life.span, with the aim of developing more individualized assessment and intervention tools.
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Aminu Sanda, Mohammed. "Validity and rationality of using neuroergonomics concept in exploring worker mental issues in systemic-activity theoretical research." In 14th International Conference on Applied Human Factors and Ergonomics (AHFE 2023). AHFE International, 2023. http://dx.doi.org/10.54941/ahfe1003003.
Повний текст джерелаАнотація:
It is known fact that the brain is the most complex organ in the human body. Over the last few decades, mapping of the human brain connectivity to human activity has gained considerable attention not only in the areas of neuroscience and cognitive neuroscience, but also in the field of human factors and ergonomics. The field has benefitted greatly from the inclusion and integration of neuroscientific methods and theory, with the argument that synergistic success of such integration could work in the other direction with the inclusion of neuro-field methods and theory of human factors, such as neuro-psychology or neuroergonomics., which incorporates knowledge on workload measures and theory. Thus, the field of human factors and ergonomics has benefitted from the committed inclusion of neuro-based methods and techniques, and it continues to develop and advance in a variety of interesting ways. In this wise, continuous efforts in the neuroergonomics field have been devoted to studying brain signals relative to human systemic activity at work and in everyday settings. Though the number of useful analytical approaches used in neuroergonomics research has rapidly expanded, there is the argument that the functional brain connectivity and network topology in the context of neuroergonomics is largely unknown. Hence, modern network science, entailing a synergetic mix of dynamic systems theory, graph theory, and statistics, is applied in studying the functional and structural brain connectivity network under various states and conditions. Such synergistic relationship is deemed to work in the reverse direction, with methods and measures of human factors and neuroergonomics benefitting other disciplines, such as the systemic structural activity theory (SSAT) approach. SSAT establishes that knowledge derived from ergonomics and activity theory is uniquely capable of engaging with different ways of knowing the world of work, generating new knowledge, and helping stakeholders understand and incorporate the results or lessons learned. Even though previous studies have succeeded in quantifying a great variety of cognitive and physical measures of human tasks, the SSAT approach has been used to understand the mental and physical systemic activities entailed in human dynamic temporal interactions during everyday tasks. This therefore brings to the fore the debate on the validity and rationality of using neuroergonomics concept in exploring worker mental issues in systemic-activity theoretical research. In neuroergonomics studies using the SSAT approach, mental workload is a multidimensional construct and widely invoked concepts, whose assessment has been of great interest. In the SSAT approach, the neuro-indices of cognitive workload have been discussed in the context of human mental load and working memory related to the process of storing and processing information, and which in the workplace require the manipulation and recall of information for decision-making and problem-solving. In this wise, this paper will argue on the validity and rationality of using neuroergonomics concept in the SSAT approach, which has been used in many situations to establish the relation between worker ability to recall and store information to fatigue, stress, and workload, which in turn affects attention levels, situational awareness, and learning performance.
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Pontes, Maria Cibele Lima, Vinícius Romeu Beserra Diógenes, Natália Carolina Medeiros do Nascimento Rodrigues, Ellen de Fátima Lima Vasconcelos, Maria Carolina Othon de Queiroz, Adrielle de Paula Miranda, Beatriz Ferreira Pereira Pacheco, and Katiane Fernandes Nóbrega. "Neural factors that define religiosity: neurophysiological distinction between the individual with religious and non-religious beliefs." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.694.
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Introduction: Religiosity and mystical experiences accompany society throughout history, integrating its identity formation. Neuroscience unveils neural correlations, maps the areas involved and activity patterns, and functional magnetic resonance imaging (fMRI) is applied to detect variations in activation of neural activity. Objectives: Thus, the objective is to understand the neurophysiological differences between individuals who experience religiosity and the mystical experiences of those without, through the fMRI. Methods: This literature review, collected data in April/2021 on Medline, Pubmed and Science Direct. The descriptors used, after consulting the MeSH, consisted of “neural correlates of religious”, “mystical experience” and “functional magnetic resonance imaging (fMRI)”. Were found 227 articles, after applying the exclusion criteria and fully reading of the abstract, the sample included 6 articles in English, from the last 10 years, available in full text, 2 Medline, 3 Pubmed and 1 Science Direct. Results: The consensus was reached that religiosity can be grounded by neural factors, by applying fMRI to identify patterns of activation of brain regions during mystical experience, although one of the articles refutes these relationships. Correlations are cited by regions: frontal and temporal - emphasis on the dorsolateral and medial/superior prefrontal cortex and bilateral lower parietal lobes, as promoters or impeders of the religious profile in individuals, due to the negative regulation due to lack of excitement, injuries or structural changes. Conclusions: It is concluded that the neurophysiological findings were able to detect patterns that can serve as eligibility criteria between believing and non- believing individuals, which makes their subsequent application feasible for better clarification and neural distinction.
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Gu, Shi, and Shikuang Deng. "Controllability Analysis on Functional Brain Networks." In 2018 Conference on Cognitive Computational Neuroscience. Brentwood, Tennessee, USA: Cognitive Computational Neuroscience, 2018. http://dx.doi.org/10.32470/ccn.2018.1168-0.
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Madar, Asaf, Vered Kurtz-David, Adam Hakim, Dino Levy, and Ido Tavor. "Pre-acquired functional connectivity predicts choice inconsistency." In 2023 Conference on Cognitive Computational Neuroscience. Oxford, United Kingdom: Cognitive Computational Neuroscience, 2023. http://dx.doi.org/10.32470/ccn.2023.1382-0.
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Zhang, Yu, and Pierre Bellec. "Functional Decoding using Convolutional Networks on Brain Graphs." In 2019 Conference on Cognitive Computational Neuroscience. Brentwood, Tennessee, USA: Cognitive Computational Neuroscience, 2019. http://dx.doi.org/10.32470/ccn.2019.1384-0.
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Muukkonen, Ilkka, and Viljami Salmela. "Face-voice –integration in dorsal STS." In 2023 Conference on Cognitive Computational Neuroscience. Oxford, United Kingdom: Cognitive Computational Neuroscience, 2023. http://dx.doi.org/10.32470/ccn.2023.1265-0.
Повний текст джерелаЗвіти організацій з теми "Functional integration in neuroscience"
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Whitten, Lori. Functional Magnetic Resonance Imaging (fMRI): An Invaluable Tool in Translational Neuroscience. Research Triangle Park, NC: RTI Press, December 2012. http://dx.doi.org/10.3768/rtipress.2012.op.0010.1212.
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Donchin, Emanuel. Towards an Integration of the Non-Invasive Methodologies of Cognitive Neuroscience: The Eleventh Carmel Workshop. Fort Belvoir, VA: Defense Technical Information Center, September 1990. http://dx.doi.org/10.21236/ada228945.
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Mitchell, Hugh, and Jennifer Kyle. Full Integration of Lipidomics Data into Multi-OMIC Functional Enrichment. Office of Scientific and Technical Information (OSTI), November 2019. http://dx.doi.org/10.2172/1986189.
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Truong, Kris, and Michell Dolfini-Reed. Behavioral Health Care Delivery Models and Examples: Contractual to Functional Integration. Fort Belvoir, VA: Defense Technical Information Center, November 2000. http://dx.doi.org/10.21236/ada401079.
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Olson, G. L., J. A. Roth, T. J. de Lyon, J. E. Jensen, and J. S. Speck. Heteroepitaxy on Compliant Substrates for Vertical and Horizontal Integration of Multi-Functional Devices. Fort Belvoir, VA: Defense Technical Information Center, October 2001. http://dx.doi.org/10.21236/ada389552.
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Fenves, Steven J., Young Choi, Balan Gurumoorthy, Greg Mocko, and Ram D. Sriram. Master product model for the support of tighter integration of spatial and functional design. Gaithersburg, MD: National Institute of Standards and Technology, 2003. http://dx.doi.org/10.6028/nist.ir.7004.
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Bulmer-Thomas, Victor. Belize's Regional Integration Options. Inter-American Development Bank, July 2013. http://dx.doi.org/10.18235/0009136.
Повний текст джерелаАнотація:
In order to thrive, small economies like Belize tend to depend heavily on the external sector to compensate for their limited domestic market. With a population of less than 350,000, Belize is too small to provide a profitable domestic market for producers of goods and services. Considering this reality, successive Belizean governments have recognized that international trade is critical to ensure a sustainable economic development. While trade remains a top priority for Belize, preferential treatment of its exports to main markets - the US and the European Union - is progressively eroding. One way for Belize to mitigate the impact of diminishing preferences to traditional markets is to participate effectively in integration schemes with its neighbors in Latin America and the Caribbean in order to maximize benefits from economic integration and functional cooperation. The objective of this study is to re-evaluate the potential of integration into the three regions to which Belize belongs: the Caribbean, Central America and Mexico. The paper suggests that Belize is not fully integrated into any of the three regions despite forty years of membership in CARICOM and close geographical proximity to Central America and Mexico. The study presents an analysis of the reasons, both economic and political, for the limitations of close integration with the three regions. It concludes by recommending a strategic policy mix of integration initiatives that would provide the greatest economic and social benefits for Belize.
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Brand, Marissa, Gerald Key, Ed Herricks, Ryan King, J. T. Nohara, Jr Gauthreaux, Begier Sidney, et al. Integration and Validation of Avian Radars (IVAR): Functional Requirements and Performance Specifications for Avian Radar Systems. Version 3.0. Fort Belvoir, VA: Defense Technical Information Center, December 2011. http://dx.doi.org/10.21236/ada581966.
Повний текст джерела
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Wirkierman, Ariel Luis. Distributive Profiles Associated with Domestic Versus International Specialization in Global Value Chains. Institute for New Economic Thinking Working Paper Series, January 2023. http://dx.doi.org/10.36687/inetwp200.
Повний текст джерелаАнотація:
The present paper sets out trends in the functional income distribution implied by countries’ integration in Global Value Chains (GVCs), taking account also of interregional interactions (South-South and North-South). Through the application of an innovative input-output methodology, it quantifies inter-country differences in functional income distribution by means of a novel indicator to estimate the distributive profile associated with domestic vis-à-vis international specialization. The focus is on trade flows, and the analysis carried out allows us to single out the distributive implications of alternative regional integration projects, in view of a more inclusive multilateral trade system.
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Newton, Ronald, Joseph Riov, and John Cairney. Isolation and Functional Analysis of Drought-Induced Genes in Pinus. United States Department of Agriculture, September 1993. http://dx.doi.org/10.32747/1993.7568752.bard.
Повний текст джерелаАнотація:
Drought is a common factor limiting timber production in the U.S. and Israel. Loblolly (Pinus taeda) and alleppo pine (Pinus halepensis) seedling survival is reduced when out planted, and growth and reproduction are often hindered by periodic droughts during later stages of tree development. Molecular and gene responses to drought stress have not been characterized. The objectives were to characterize drought-induced gene clones from these pines, to determine the effects of a growth regulator on drought tolerance, ABA levels, and drought-induced gene expression in alleppo pine, and to develop procedures for loblolly pine transformation. Nearly 20 cDNA clones influenced by gradual, prolonged drought stress have been isolated. Many of these have been shown to be induced by drought stress, whereas several others are down-regulated. These are the first drought-induced genes isolated from a pine species. Two genomic clones (lp5-1 and lp3-1) have been sequenced and characterized, and each has been found to be associated with a gene family. Clone lp5 appears to code for a cell wall protein, and clone lp3 codes for a nuclear protein. The former may be associated with changing the elastic properties of the cell wall, while the latter may be involved in signal transduction and/or protection from desiccation in the nucleus. Clone lp3 is similar to a drought-induced gene from tomato and is regulated by ABA. Several DNA sequences that are specific to induction during growth-retardation in alleppo pine by uniconazole have been identified. The active DNA species is now being identified. Promoters from genomic clones, lp3 and lp5, have been sequenced. Both are functional when fused with the gus reporter gene and transferred to other plant tissues as well as responding to a simulated drought stress. Through exodeletion analysis, it has been established that the promoter ABRE element of lp3 responds to ABA and that drought-induction of lp3 expression may also involve ABA. Stable tobacco transformants carrying either the lp5 or the lp3 promoter fused to a reporter gus gene have been obtained. The lp5lgus fusion was expressed at several stages of tobacco development and differentiation including the reproductive stage. There was no difference in phenotype between the transformants and the wild type. Embryogenesis procedures were developed for slash pine, but attempts to couple this process with gene transfer and plantlet transformation were not successful. Transformation of pine using Agrobacterium appears tractable, but molecular data supporting stable integration of the Agrobacterium-transferred gene are still inconclusive.