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Добірка наукової літератури з теми "Food allergy, asthma, allergenes"

Автор: Grafiati

Опубліковано: 11 березня 2023

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Статті в журналах з теми "Food allergy, asthma, allergenes"

Barilo, Anna A., Svetlana V. Smirnova, V. D. Belenyuk, Andrei A. Savchenko, and Aleksandr G. Borisov. "Issues of specific <i>in vitro</i> allergological diagnosis of atopic conditions." Russian Journal of Immunology 26, no. 1 (December 22, 2022): 69–76. http://dx.doi.org/10.46235/1028-7221-1156-ios.

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There is a steady increase in the prevalence of allergic diseases of atopic origin worldwide, e.g., atopic bronchial asthma (ABA) and atopic dermatitis (AD). Identification of a causally significant allergen in allergic patients is crucial for the diagnosis, therapy and prevention of allergic diseases. Korea has developed the Allergy-Q multiplex test to detect specific IgE. Allergy-Q is based on an immunoblotting method using a nitrocellulose membrane as a solid phase for allergen immobilization and can detect allergen-specific IgE simultaneously to 107 allergens. Our aim was to conduct a comparative analysis for detectable allergen-specific IgE antibodies to food, fungal, pollen, household, epidermal allergens in blood serum by immunoblotting method using the Allergy-Q test system in patients with atopic dermatitis, atopic bronchial asthma and psoriasis. The study included patients with atopic dermatitis (AD, group 1, n = 9), atopic bronchial asthma (ABA, group 2, n = 14) and psoriasis (PS, group 3, n = 17). The concentration of total immunoglobulin E and allergen-specific immunoglobulins of class E in blood serum to 32 most common food, fungal, pollen, household, epidermal allergens was determined by the immunoblotting method using the Allergy-Q test system (Korea). We have found that sensitization of atopic origin was observed in all patients with AD (n = 9), in 85.7% (n = 12) of patients with atopic bronchial asthma, and in 47.1% (n = 8) of patients with psoriasis. Polyvalent sensitization was shown to prevail in all groups of the examined persons. When studying the spectrum of sensitization to food allergens, a significantly increased frequency of positive reactions to cows milk protein was found in the group of patients with AAA as compared with AD and PS groups. Among all studied groups, sensitization to the Alternaria fungi was found at the highest frequency in the group of patients with ABA. Sensitization to ragweed pollen was very common in all groups of patients. Sensitization to household and epidermal allergens in the groups with AD and AAA was noted for all studied allergens with the highest positivity rates for the feline epithelium and dog dander. In the present study, the Allergy-Q system showed an agreement with preliminary data from a specific allergological examinations. This relationship suggests a potential for usage of the Allergy-Q immunoblotting method as a highly effective alternative to other in vitro tests for diagnosing atopy. An advantage of the Allergy-Q Multiplex Serum Allergen-Specific IgE Detection Kit is a short processing time, small amount of blood sample, and broader clinical information on the causative allergens.

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Ali, Abdellah H. K. "Food and Aeroallergen Sensitization in IgE -Mediated Asthma in Egypt." Open Respiratory Medicine Journal 15, no. 1 (December 31, 2021): 52–58. http://dx.doi.org/10.2174/1874306402115010052.

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Purpose: Identifying the distribution of allergens is valuable to the effective diagnosis and treatment of allergic disease. So, our aim is to explore the sensitization of food and aeroallergens in Egyptian patients with atopic asthma. Methods: Cross-sectional study recruited 268 Egyptian patients with atopic asthma. Asthmatic patients were assessed by the enzyme allegro sorbent test (EAST) method for specific IgE to a panel of 19 common regional inhaled allergens and 15 food allergens. Results and Discussion: One hundred percent of the patients were sensitive to at least one allergen. Allergy to food allergens only was 2.9%; inhaled allergens only were 26.2% and both were70.9%. Fungi (62%) were the most frequent sensitizing aeroallergen amongst our asthmatic patients, followed by the pollen allergens (42.5%) and house dust mites (HDMs) (26%). Cows’ milk (30.5%) was the most frequent sensitizing food amongst our asthmatic patients, followed by eggs (22.4%) and fish (21.6%). Mono-sensitized patients accounted for 6.7% of all cases, while polysensitized was 93.3%. Moderate and severe asthma showed a significantly higher frequency of polysensitization compared to mild asthma. Conclusion: Fungi and cow's milk are the chief sensitizing allergens in Egyptian patients with atopic asthma. This study represents the first report of sensitization in atopic adult asthma using a large extract panel in Upper Egypt.

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Zhang, Wei, Biao Xie, Meina Liu, and Yupeng Wang. "Associations between sensitisation to allergens and allergic diseases: a hospital-based case–control study in China." BMJ Open 12, no. 2 (February 2022): e050047. http://dx.doi.org/10.1136/bmjopen-2021-050047.

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ObjectivesTo assess the associations of sensitisation to common allergens with atopic dermatitis, allergic rhinitis and allergic asthma in adults.DesignCase–control study.SettingData were collected from the First Affiliated Hospital of Harbin Medical University in Harbin, China.ParticipantsCases were 5111 patients with physician-diagnosed atopic dermatitis (n=2631), allergic asthma (n=1320) and allergic rhinitis (n=1160) recruited from the department of allergy from March 2009 to December 2017. Controls were 2576 healthy adults who underwent physical examination at the same hospital during the same period.Main outcome measuresSpecific IgE levels to 16 common food, indoor and outdoor allergens were assessed in all participants. Adjusted ORs and 95% CIs for the association between allergen sensitisation and allergic diseases were estimated using multivariate logistic regression.ResultsThe prevalence of allergen sensitisation was higher in patients with atopic dermatitis (indoor=17.14%, outdoor=12.85%, food=21.44%), allergic rhinitis (indoor=23.18%, outdoor=26.81%, food=8.94%) and allergic asthma (indoor=24.65%, outdoor=16.46%, food=14.31%) compared with controls (indoor=11.03%, outdoor=6.84%, food=5.83%). After adjustment for potential confounding variables, there was a dose–response relevance between the levels of allergen-specific IgE and allergic diseases (p trend <0.0001). The number of allergens to which a patient was sensitised increased the risk of allergic diseases (atopic dermatitis: highest adjusted OR=4.28, 95% CI 2.57 to 7.11; allergic rhinitis: highest adjusted OR=13.00, 95% CI 3.76 to 45.00; allergic asthma: OR=2.37, 95% CI 1.67 to 3.37).ConclusionThere was a dose–response relevance between levels of allergen-specific IgE and allergic diseases’ prevalence, and multiple sensitisations increased the risk of allergic diseases. This study provides evidence for the prophylaxis of allergic diseases.

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Lei, Dawn K., and Carol Saltoun. "Allergen immunotherapy: definition, indications, and reactions." Allergy and Asthma Proceedings 40, no. 6 (November 1, 2019): 369–71. http://dx.doi.org/10.2500/aap.2019.40.4249.

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Specific allergen immunotherapy is the administration of increasing amounts of specific allergens to which the patient has type I immediate hypersensitivity. It is a disease-modifying therapy, indicated for the treatment of allergic rhinitis, allergic conjunctivitis, allergic asthma, and Hymenoptera hypersensitivity. Specific immunoglobulin E (IgE) antibodies for appropriate allergens for immunotherapy must be documented. Indications for allergen immunotherapy include (1) inadequate symptom control despite pharmacotherapy and avoidance measures; (2) a desire to reduce the morbidity from allergic rhinitis and/or asthma, or reduce the risk of anaphylaxis from a future insect sting; (3) when the patient experiences undesirable adverse effects from pharmacotherapy; and (4) when avoidance is not possible. Several studies reported that immunotherapy in allergic rhinitis seems to prevent the development of new allergic sensitizations and/or new onset asthma. Humoral-, cellular-, and tissue-level changes occur with allergen immunotherapy, including induction of allergen-specific regulatory T and B cells, interleukin 10, and transforming growth factor β production; suppression of T-helper type 2 cell proliferation; large increases in anti-allergen IgG4 antibodies; and reduction in basophil, mast cell, and eosinophil mediator release. Allergen immunotherapy can be administered either subcutaneously in the physician's office or sublingually by the patient at home. The use of immunotherapy in food allergy is still under investigation.

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Klimov, A. V., P. Yu Isaev, V. V. Klimov, and V. S. Sviridova. "Endotypes of allergic rhinitis and asthma accompanying food allergy." Bulletin of Siberian Medicine 18, no. 2 (August 11, 2019): 287–89. http://dx.doi.org/10.20538/1682-0363-2019-2-287-289.

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61 people suffering from persistent allergic rhinitis and asthma accompanying food allergies were studied using case histories, the NHANES questionnaire, polyspecific serum levels, allergen-specific IgE, IL4, IFNg and IL10 assays, and allergy skin tests. Four different endotypes have been identified, including entopic, which can be the basis for new approaches to the diagnosis and treatment of allergic rhinitis and asthma.

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Logan, Kirsty, George Du Toit, Mattia Giovannini, Victor Turcanu, and Gideon Lack. "Pediatric Allergic Diseases, Food Allergy, and Oral Tolerance." Annual Review of Cell and Developmental Biology 36, no. 1 (October 6, 2020): 511–28. http://dx.doi.org/10.1146/annurev-cellbio-100818-125346.

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Pediatric allergic disease is a significant health concern worldwide, and the prevalence of childhood eczema, asthma, allergic rhinitis, and food allergy continues to increase. Evidence to support specific interventions for the prevention of eczema, asthma, and allergic rhinitis is limited, and no consensus on prevention strategies has been reached. Randomized controlled trials investigating the prevention of food allergy via oral tolerance induction and the early introduction of allergenic foods have been successful in reducing peanut and egg allergy prevalence. Infant weaning guidelines in the United Sates were recently amended to actively encourage the introduction of peanut for prevention of peanut allergy.

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Knyziak-Mędrzycka, Izabela, Emilia Majsiak, and Bożena Cukrowska. "Allergic March in Children: The Significance of Precision Allergy Molecular Diagnosis (PAMD@) in Predicting Atopy Development and Planning Allergen-Specific Immunotherapy." Nutrients 15, no. 4 (February 15, 2023): 978. http://dx.doi.org/10.3390/nu15040978.

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The allergic march is a progression of naturally occurring symptoms whose nature changes with age. The classic allergic march typically begins in infancy and manifests in the form of atopic dermatitis and food allergy. As immune tolerance develops over time, these conditions may resolve by the age of 3–5 years; however, they may evolve into allergic rhinitis and bronchial asthma. Traditional diagnostic assessments, such as skin prick testing or serum allergen-specific immunoglobulin E (sIgE) level testing, are conducted to introduce effective treatment. Recent years saw the emergence of precision allergy molecular diagnosis (PAMD@), which assesses sIgE against allergenic molecules. This new technology helps more accurately evaluate the patient’s allergy profile, which helps create more precise dietary specifications and personalize allergen-specific immunotherapy. This review presents possible predictions regarding the allergic march and the means of controlling it based on PAMD@ results.

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Huang, Yan-yan, Yan-tong Liang, Jia-min Wu, Wei-tong Wu, Xin-tong Liu, Ting-ting Ye, Xiao-rong Chen, Xin-An Zeng, Muhammad Faisal Manzoor, and Lang-hong Wang. "Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy." Molecules 28, no. 3 (January 27, 2023): 1242. http://dx.doi.org/10.3390/molecules28031242.

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Food allergies are a serious food safety and public health issue. Soybean, dairy, aquatic, poultry, and nut products are common allergens inducing allergic reactions and adverse symptoms such as atopic dermatitis, allergic eczema, allergic asthma, and allergic rhinitis. Probiotics are assumed as an essential ingredient in maintaining intestinal microorganisms’ composition. They have unique physiological roles and therapeutic effects in maintaining the mucosal barrier, immune function, and gastrointestinal tract, inhibiting the invasion of pathogenic bacteria, and preventing diarrhea and food allergies. Multiple pieces of evidence reveal a significant disruptive effect of probiotics on food allergy pathology and progression mechanisms. Thus, this review describes the allergenic proteins as an entry point and briefly describes the application of probiotics in allergenic foods. Then, the role of probiotics in preventing and curing allergic diseases by regulating human immunity through intestinal flora and intestinal barrier, modulating host immune active cells, and improving host amino acid metabolism are described in detail. The anti-allergic role of probiotics in the function and metabolism of the gastrointestinal tract has been comprehensively explored to furnish insights for relieving food allergy symptoms and preventing food allergy.

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di Palmo, Emanuela, Marcella Gallucci, Francesca Cipriani, Luca Bertelli, Arianna Giannetti, and Giampaolo Ricci. "Asthma and Food Allergy: Which Risks?" Medicina 55, no. 9 (August 21, 2019): 509. http://dx.doi.org/10.3390/medicina55090509.

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Over the past few decades, an increase in the prevalence of asthma and food allergy has been observed in the pediatric population. In infants, food sensitization, particularly to egg, has increased the risk of developing allergic asthma. This is even more likely if sensitization to food allergens occurs early within the first few years of life. It is indeed known that both diseases may be present simultaneously in the pediatric population, but coexistence may negatively influence the severity of both conditions by increasing the risk of life-threatening asthmatic episodes as well as food-related anaphylaxis. Therefore, an accurate clinical and phenotype characterization of this high-risk group of children with both asthma and food allergy and a more aggressive management might lead to reducing related morbidity and mortality. The aim of this review is to provide an updated overview on the close link between food allergy and asthma and their negative mutual influence.

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Dange, Hemalata V. "INVOLVEMENT OF SOME ALLERGENS OF PLANT AND ANIMAL ORIGIN IN ALLERGIC REACTIONS RELATED TO RESPIRATORY SYSTEM." Journal of Medical pharmaceutical and allied sciences 11, no. 6 (November 15, 2021): 76–74. http://dx.doi.org/10.22270/jmpas.v10i6.1947.

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In India, the prevalence of allergic responses and bronchial asthma is on the rise, which is a major public health concern. Increased exposure to an allergen, a substance that causes a reaction, can cause allergy sensitization in genetically vulnerable people. Continued exposure to allergens can raise the risk of allergic diseases which can further progress into life threating respiratory diseases. Allergic reactions to a variety of indoor and outdoor allergens play a key role in severe breathing disorders such as asthma and chronic obstructive pulmonary disease (COPD). There are distinctive kinds of allergens like animal proteins and animal dander, pollen, food, fungi, mould, Insects, Bird droppings and many others. The common allergens that cause respiratory difficulties have been identified after an honest effort. A modest retrospective analysis of 160 patients was done. Their medical history was gathered in order to determine whether or not they had been exposed to allergies in the past. All of the study participants were given a Skin prick test (SPT) with a variety of allergens, and their allergy status was evaluated based on the results. Most allergens, such as dust mites, pollen grains, and pigeon droppings, have been discovered to cause severe respiratory allergies, which can lead to life-threatening respiratory complications.

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Більше джерел

Дисертації з теми "Food allergy, asthma, allergenes"

Sichili, Stefania. "Allergia alimentare ed Asma Bronchiale." Doctoral thesis, Università di Catania, 2013. http://hdl.handle.net/10761/1437.

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L allergia Alimentare rappresenta una della cause di Asma bronchiale spesso sottovalutata e poco considerata al momento della diagnosi in quanto rappresenta una piccola percentuale dei fenotipi dell asma allergico. Lo scopo dello mio studio è di valutare la prevalenza di asma bronchiale secondaria ad allergia alimentare e le loro caratteristiche, nei pazienti afferenti al ambulatorio di Allergologia dell Ospedale Policlinico di Catania dal mese di gennaio a dicembre 2011. Metodi: Dal mese di Gennaio al mese di Dicembre 2011 sono giunti presso il nostro ambulatorio 4544 pazienti per sospetta patologia di natura allergica. I pazienti affetti da asma bronchiale erano 1233 rappresentando quindi solo il 27 % delle utenze. Il restante 73% dei pazienti avevano effettuato una visita allergologica perché lamentavano orticaria acuta o cronica, dermatite allergica o irritativa da contatto, intolleranza al lattosio, rinite allergica ecc. Considerando il gruppo di pazienti affetti da asma bronchiale solo il 6% (75 pazienti su 1233) presentava asma da allergia alimentare all anamnesi. La situazione clinica è stata confermata dal prick test, dalla misura delle IgE sieriche specifiche (RAST, Radio-Allergo-Sorbent Test) e dallo studio spirometrico per stabilire il grado dell asma. Risultati: Sono stati arruolati nello studio i 75 pazienti affetti da asma bronchiale secondaria ad allergia alimentare i quali rappresentano il 6% dei pazienti del nostro ambulatorio osservate tra gennaio e dicembre 2011. Avevano un età compresa tra i 5 ed i 65 anni, con una prevalenza per il sesso femminile (50 contro 25 maschi). Sono state prese in considerazione 5 fasce d età: da 0-6 anni; 7-18 anni; 19-35 anni; 36-50 anni e > 50 anni. L età compresa fra i 36-50 anni è la più rappresentativa in conformità alle utenze del nostro ambulatorio che si occupa prevalentemente di adulti. Il gruppo arruolato presentava all anamnesi oltre l asma conseguente all ingestione di alimenti rinite o orticaria allergica. Nel 43% dei casi vi era associata una rinite allergica nel 8% dei casi orticaria allergica mentre nel 15 % dei casi le due comorbilità coesistevano. Nel gruppo arruolato l anamnesi di asma da alimenti è stata confermata con i test diagnostici allergologici a nostra disposizione: il prick test ed il dosaggio delle IgE specifche sieriche che ci hanno permesso di effettuare una distribuzione degli allergeni alimentari. In particolar modo è possibile notare che il grano è l allergene più rappresentativo proprio perché il target d età dei nostri pazienti appartiene ad una fascia adulta in accordo con ciò che è evidente in letteratura. Conclusioni: In questo studio i pazienti affetti da asma bronchiale da allergia alimentare sono prevalentemente di sesso femminile. Il nostro gruppo presentava all anamnesi oltre l asma conseguente all ingestione di alimenti, rinite o orticaria allergica. Nel 43% dei casi vi era associata una rinite allergica nel 8% dei casi orticaria allergica mentre nel 15 % dei casi le due comorbilità coesistevano. Nel gruppo arruolato l anamnesi di asma da alimenti è stata confermata con i test diagnostici allergologici a nostra disposizione: il prick test ed il dosaggio delle IgE specifiche sieriche. Nei nostri pazienti il grano è l allergene più rappresentativo proprio perché il target d età dei nostri pazienti appartiene ad una fascia adulta in accordo con ciò che è evidente in letteratura.

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Patelis, Antonios. "IgE sensitization against food allergens : Natural history, relation to airway inflammation and asthma." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-251396.

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Background: According to recent studies in children, IgE sensitization not only against perennial allergens, but also against food allergens, is related to asthma risk and increased airway inflammation. During the last decade, a new technique for IgE determination based on allergen components has become available, but its use in epidemiological studies has been limited. Aims: To investigate the relationship between the pattern of IgE sensitization to allergen components and the prevalence of asthma, airway inflammation and hyperresponsiveness in a population-based setting. To examine the relationship of IgE sensitization to allergen extract, and airway inflammation, airway hyperresponsiveness and blood eosinophilia in asthmatics. To examine the natural history of IgE sensitization to food allergens in adults. To compare extract-based and component-based IgE measurements in relation with new-onset respiratory disease and airway inflammation and hyperresponsiveness. Methods: The present thesis is based on cross-sectional and longitudinal analyses of the adult, the population-based study ECRHS (European Community Health Survey) and a cross-sectional, observational study of young subjects with asthma. IgE sensitization was examined by means of both extract-based and component-based tests. Airway inflammation was assessed by exhaled NO and airway hyperresponsiveness with methacholine test. Results: IgE sensitization to food allergens independently related to increased airway inflammation in both a population-based study and a study of asthmatics. Furthermore, a relation was found with increased blood eosinophils in asthmatics. The decrease in prevalence of IgE sensitization against food allergens during a 9-year follow-up was larger than the decrease of aeroallergens. Subjects with IgE sensitization to both cat extract and components showed more frequent airway inflammation, greater bronchial responsiveness and higher likelihood of developing asthma and rhinitis than subjects with IgE sensitization only to cat extract. Conclusions: The presence of IgE antibodies against food allergens was independently associated with airway and systemic inflammation. Both aeroallergens and food allergens should be examined in order to understand the signaling of local and systemic inflammation in asthma. Prevalence of IgE sensitization to food decreased in adults to a larger extent than IgE sensitization against aeroallergens. Measurement of IgE sensitization to cat allergen components appears to have a higher clinical value than extract-based measurement

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Kull, Inger. "Infant feeding and allergy in children /." Stockholm : Karolinska institutet, 2005. http://diss.kib.ki.se/2005/91-7140-553-4/.

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West, Meghan V. "The Sensitivity to Food Allergies in Individuals with Asthma." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1592168710140387.

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Bonnegarde-Bernard, Astrid. "Régulation des réponses immunitaire allergiques par la kinase IKKb des cellules épitheliales intestinales : Effect sur les reactions allergique inflammatoires au niveau des muqueuses pulmonaires et de la peau." Thesis, Paris, AgroParisTech, 2013. http://www.theses.fr/2013AGPT0084.

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La régulation de l'homéostasie intestinale est de la plus haute importance en raison de la constante exposition de l'intestin aux antigènes alimentaires et à la flore commensale. La perturbation de la flore intestinale est souvent associée à diverses maladies telles que l'allergie, l'obésité et certaines maladies inflammatoires. La plupart des individus sont tolérant aux antigènes alimentaires et ne développe pas de réponse immunitaire sauf en cas de prédisposition génétique ou d'exposition à un environnement défavorable. La réponse allergique se caractérise par la production d'IgE stimulé par les lymphocytes Th2. Les symptômes allergiques sont très variés et affectent plusieurs parties de l'organisme. La plupart des travaux de recherche se sont focalisé jusqu'à présent sur le rôle des cellules de l'immunité adaptative dans le développement de l'allergie en sous-estimant le rôle majeur des cellules épithéliales et des cellules de l'immunité innée. L'objectif de ce projet est de comprendre comment les cellules épithéliales intestinales modulent la réponse immunitaire à distance vers la muqueuse pulmonaire ou la peau après stimulation allergique. L'ingestion de l'antigène associé à l'adjuvant de la toxine cholérique permet d'étudier la réponse allergique chez l'animal. Nous avons démontré sur ce modèle animal que l'absence de la kinase inhibitrice IKKb dans la voie de signalisation du facteur de transcription NF-kB altère la composition de la flore intestinal d'une part et transforme la réponse immunitaire inflammatoire au niveau pulmonaire et de la peau grâce à la présence d'IgA et de lymphocyte Th17 d'autre part. En adéquation avec les observations cliniques rapportées chez les patients allergiques (allergies alimentaires, asthme, dermatite atopique), nos résultats identifient IKKb dans la cellule épithéliale intestinale comme cible potentielle pour traiter les allergies alimentaires. De futurs efforts devront être faits pour développer de nouvelles stratégies thérapeutiques qui considèrent la muqueuse intestinale, la production d'IgA et l'importance des bactéries commensales dans le traitement des allergies
Immune homeostasis is of paramount importance in the gastrointestinal tract, which is constantly exposed to ingested antigens and commensal microbiota. The gut microbiota can be perturbed by endogenous or exogenous factors and it is now established that microbial dysbiosis is associated with allergy, obesity, and inflammatory diseases. Ingestion of food antigens generally fails to promote brisk immune responses but rather results in a state of immune tolerance. However, aberrant immune responses can develop in individuals with a genetic predisposition. Food allergies are generally regarded as pathologic responses to food antigens mediated by excessive Th2 responses and antigen-specific IgE antibody responses. Clinical manifestations of food allergies are very broad and symptoms can affect different organs. While past research on allergy focused on the role of cells and molecules involved in adaptive immunity, epithelial cells lining the sites of antigen entry and innate immune responses have recently emerged as important players in allergy. This project was undertaken to understand the mechanisms employed by intestinal epithelial cells (IECs) to shape immune responses to allergens and influence allergic manifestations in distant mucosal sites such as the airways or the skin. Oral administration of food antigen with cholera toxin as adjuvant in experimental animals is a well-accepted model to study allergic sensitization to food antigens. Using this model, we show that a localized impairment of the canonical NF-κB pathway through deletion of IkB kinase (IKKβ) in IECs alters the gut microbiota during oral allergic sensitization and regulates the magnitude of allergic inflammatory responses at distant sites of the airway and the skin through enhancement of IgA Abs and Th17 responses. Consistent with the clinical observations linking atopic diseases (food allergy, allergic asthma, atopic dermatitis), our results identify IKKβ in IECs as a potential therapeutic target for treatment of food allergies and subsequent disease. They also suggest that future efforts for controlling allergic responses in the airways and the skin could include strategies that use the gut microbiota and promote IgA Ab responses and prevent IL-17 responses

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Wickrama, Gunaratne Anoja. "Effects of n-3 LCPUFA supplementation for pregnant and lactating women in preventing allergic diseases in early childhood." Thesis, 2015. http://hdl.handle.net/2440/115480.

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It is postulated that maternal n-3 (omega 3) long chain polyunsaturated fatty acids (LCPUFA) supplementation may modulate a range of inflammatory and immune pathways involved in the development of allergic diseases in early childhood, potentially leading to a reduction of allergic diseases in children. Thus the focus of this thesis was to determine whether maternal n-3 LCPUFA supplementation during pregnancy or lactation could prevent allergies in children. Two nested follow-up studies from two randomised controlled trials (RCTs) were performed, as well as a Cochrane systematic review to address this question. Of the two nested follow-up studies, one was a prenatal n-3 LCPUFA supplementation and the other a postnatal n-3 LCPUFA supplementation study. Parental reports of allergy outcomes were evaluated in children between birth to three years of age and birth to seven years of age in these studies. The Cochrane systematic review and meta-analysis was used to determine overall effects of maternal n-3 LCPUFA supplementation on allergy outcomes of the children involved. All relevant RCTs to date and the data from my two follow-up studies were included in the systematic review. Eight trials involving 3366 women and their 3175 children were included and in these trials, women were supplemented with n-3 LCPUFA during pregnancy (five trials), lactation (two trials) or both pregnancy and lactation (one trial). All trials randomly allocated women to either a n-3 LCPUFA supplement or a control group. The risk of bias varied across the eight included trials in this review with only two trials with a low risk of selection, performance and attrition bias. Overall, there is limited evidence to support maternal n-3 LCPUFA supplementation during pregnancy and/or lactation for reducing allergic disease in children. Few differences in childhood allergic disease were seen between women who were supplemented with n-3 LCPUFA and those who were not. N-3 LCPUFA supplementation showed a clear reduction in the primary outcome of any allergy (medically diagnosed IgE mediated) in children aged 12 to 36 months (risk ratio (RR) 0.66, 95% confidence interval (CI) 0.44 to 0.98; two RCTs; 823 children), but not beyond 36 months (RR 0.86, 95% CI 0.61 to 1.20; one RCT, 706 children). For any allergy (medically diagnosed IgE mediated and/or parental report), no clear differences were seen in children either at 12 to 36 months (RR 0.89, 95% CI 0.71 to 1.11; two RCTs, 823 children) or beyond 36 months of age (RR 0.96, 95% CI 0.84 to 1.09; three RCTs, 1765 children). For the secondary outcomes of specific allergies there were no clear differences for food allergies at 12 to 36 months and beyond 36 months, but a clear reduction was seen for children in their first 12 months with n-3 LCPUFA (both for medically diagnosed IgE mediated and medically diagnosed IgE mediated and/or parental report). There was a clear reduction in medically diagnosed IgE mediated eczema with n-3 LCPUFA for children 12 to 36 months of age, but not at any other time point for both medically diagnosed IgE mediated and medically diagnosed IgE mediated and/or parental report. No clear differences for allergic rhinitis or asthma/wheeze were seen at any time point for both medically diagnosed IgE mediated, and medically diagnosed IgE mediated and/or parental report. There was a clear reduction in children's sensitisation to egg and sensitisation to at least one allergen between 12 to 36 months of age when mothers were supplemented with n-3 LCPUFA. In terms of safety for the mother and child, n-3 LCPUFA supplementation during pregnancy did not show increased risk of postpartum haemorrhage or early childhood infections. The data obtained in one of the nested follow-up studies in this thesis was used to compare the validity of parental reports of allergy outcome measures against medical diagnosis of allergies. This revealed that parental reports of doctor diagnosed eczema were the most reliable for the diagnosis of eczema in infants, but further studies are needed to validate other allergy outcomes before parent reports of allergy symptoms can be considered as a useful tool to evaluate early childhood allergies in large scale research.
Thesis (Ph.D.) -- University of Adelaide, School of Medicine, 2015.

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Wang, Yun-Hu, and 王雲虎. "Relationship between sensitized to food allergen and childhood asthma and allergic rhinitis." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/54683190425577370466.

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碩士
中山醫學大學
醫學研究所
103
Background: Sensitisation to allergen has long been known to relate to childhood allergic disease. In general, food allergens are associated with atopic dermatitis and inhalant allergens are associated with allergic rhinitis and/or asthma. Several studies revealed that polysensitised individuals have more severe atopic disease, whereas individuals with cosensitized to food and inhalant allergen were under-researched. Objective: To realize the relationship between sensitization to food allergen and childhood allergic rhinitis and asthma. Design: This was a prospective case-controlled study. Methods: We included 138 participants with sensitized to allergen as assessed by serum-specific IgE. 87 of 138 participants had allergic rhinitis and 51 participants with both allergic rhinitis and asthma. All participants underwent a physical examination, measurement serum total IgE values and requested to complete the Pediatric Rhinoconjunctivitis Quality of Life Questionnaires (PRQLQ). Besides, nasal peak expiratory flow rate (nPEFR) was performed by allergic rhinitis participants, lung function test and asthma control test (ACT) were performed by both asthma and allergic rhinitis participants. Results: 48 of 87 allergic rhinitis participants with sensitized to food and inhalant allergens (AR food group), 39 of 87 allergic rhinitis participants with sensitized to inhalant allergen alone (AR inhalant group). AR food group significantly lower nPEFR values and higher total IgE values (p<0.05) compared with the other group. 24 of 51 both asthma and allergic rhinitis participants with sensitized to food and inhalant allergens (asthma and AR food group), 27 of 51 both asthma and allergic rhinitis participants with sensitized to inhalant allergen alone (asthma and AR inhalant group). Asthma and AR food group significantly higher total IgE values (p<0.05) compared with the other group and it was higher than the AR food group. Asthma and AR food group also had higher lung function test values and asthma control test (ACT) scores than the other group. Conclusion: This study evidences that children with sensitized to both food and inhalant allergens have more severe clinical symptoms and abnormal laboratory findings. Sensitisation to food allergen was more related to pediatric allergic rhinitis. We may need larger, longer and extended study to assess the conclusion.

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Книги з теми "Food allergy, asthma, allergenes"

Pescatore, Fred. The Allergy and Asthma Cure. New York: John Wiley & Sons, Ltd., 2003.

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Pressman, Alan H. Treating asthma, allergies, and food sensitivities. New York: Berkley Books, 1997.

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Collective, Natural Medicine, ed. The natural way of healing asthma and allergies. New York: Philip Lief Group, 1995.

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P, Crook Cynthia, ed. Detecting your hidden allergies: Foods you eat everyday can cause asthma, "sinus", headaches, fatigue, nervousness, digestive problems, arthritis ... and many other disorders. Jackson, TN: Professional Books, 1988.

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Pescatore, Fred. The allergy and asthma cure: A complete 8-step nutritional program. New York, NY: Wiley, 2003.

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Williams, Rick. Sulfites and chronic disease: Asthma, allergy, anaphylaxis, headache, hives, chronic fatigue and the brimstone demons. [United States?]: Rybett Controls, Inc., 2002.

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Food intolerance solutions: Proven solutions for relief from headache, migraine, IBS, catarrh, rhinitis, asthma, eczema, rashes, acne, fatigue and child behaviour problems. Beddington, Croydon: Filament Publishing, 2016.

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Pereira, Celso. Allergic diseases - highlights in the clinic, mechanisms and treatment. Rijeka: InTech, 2012.

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Welch, Michael J., ed. Allergies and Asthma. American Academy of Pediatrics, 2005. http://dx.doi.org/10.1542/9781581105810.

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Allergies and Asthma: What Every Parent Needs to Know is an invaluable resource for parents and caregivers trying to cope with the challenges of childhood asthma and allergies. First published 10 years ago, this well-organized guide covers such topics as: Identifying allergies and asthma, Preventing attacks, Minimizing triggers and avoiding allergens, Choosing medications wisely, Explaining allergies to young children, Helping children of all ages manage symptoms, What to do if a potentially life-threatening allergic reaction or asthma attack occurs. Allergies and Asthma now provides updated information on allergies--including the latest findings on food allergies and treatments--along with new approaches for monitoring asthma control, with expanded recommendations for children. The second edition provides new guidance on medications, new recommendations on patient education in settings beyond the physician's office, and new advice for controlling environmental factors that can cause asthma symptoms. Table of Contents includes: Allergies and Asthma Explained, Establishing the Diagnosis, Skin Allergies, Hay Fever (Allergic Rhinitis), Food Allergies, Killer Allergies: Anaphalaxis, Approaches to Allergy Treatments, An Overview of Asthma, Common Asthma Triggers and How to Identify Them, Asthma in Infants and Toddlers, Approaches to Asthma Treatments, How Environmental and Lifestyle Factors Affect Asthma Teaching Your Child the Basics of Self Care, Appendices, Hidden Sources of Food Allergens, Sources for Information About Allergies and Asthma, Sources of Allergy and Asthma Products, Practical Publications on Allergies and Asthma, Resources from the American Academy of Pediatrics, Glossary, and Index. About the Editor: Michael J. Welch, MD, FAAAAI, FAAP, CPI, is codirector of the Allergy and Asthma Medical Group and Research Center in San Diego, CA, and clinical professor at the University of California, San Diego School of Medicine. Dr Welch earned his medical degree at the University of California, Los Angeles, where he later completed an internship and residency in pediatrics and a fellowship in allergy/immunology. Dr Welch is a fellow of the American Academy of Pediatrics and the American Academy of Allergy, Asthma & Immunology. He is past president of the San Diego Allergy Society and the California Society of Allergy, Asthma and Immunology. He lives in San Diego.

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Volcheck, Gerald W. Allergy. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199755691.003.0018.

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Standard allergy testing relies on identifying the IgE antibody specific for the allergen in question. Two classic methods of doing this are the immediate wheal-and-flare skin prick tests (a small amount of antigen is introduced into the skin and evaluated at 15 minutes for the presence of an immediate wheal-and-flare reaction) and in vitro testing. Allergy testing that does not have a clear scientific basis includes cytotoxic testing, provocation-neutralization testing or treatment, and "yeast allergy" testing. Allergy-related conditions such as asthma, chronic rhinitis, urticaria and angioedema, anaphylaxis, food allergy, stinging insect allergy, and drug allergy are reviewed.

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Частини книг з теми "Food allergy, asthma, allergenes"

Chang, Christopher, Patrick S. C. Leung, Saurabh Todi, and Lori Zadoorian. "Definition of Allergens: Inhalants, Food, and Insects Allergens." In Allergy and Asthma, 1–58. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-58726-4_3-1.

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Chang, Christopher, Patrick S. C. Leung, Saurabh Todi, and Lori Zadoorian. "Definition of Allergens: Inhalants, Food, and Insects Allergens." In Allergy and Asthma, 53–110. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-05147-1_3.

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Jeebhay, Mohamed F., and Berit Bang. "Occupational Allergy and Asthma Associated with Inhalant Food Allergens." In Food Allergy, 176–202. Boca Raton, FL : CRC Press, 2017. | “A Science Publishers book.”: CRC Press, 2017. http://dx.doi.org/10.1201/9781315120126-8.

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Eapen, Amy A., and Amal Assa’ad. "Asthma." In Pediatric Food Allergy, 77–87. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33292-1_6.

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Frick, Oscar L. "Food Allergy." In Allergy and Asthma, 369–79. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30835-7_24.

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Bush, Robert K., and Michelle Montalbano. "Asthma and Food Additives." In Food Allergy, 339–45. Chichester, UK: John Wiley & Sons Ltd, 2014. http://dx.doi.org/10.1002/9781118744185.ch27.

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Sylvestre, Sebastian, and Doerthe Adriana Andreae. "IgE Food Allergy." In Allergy and Asthma, 1–39. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-58726-4_26-1.

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Sylvestre, Sebastian, and Doerthe Adriana Andreae. "IgE Food Allergy." In Allergy and Asthma, 553–91. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-05147-1_26.

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Peppers, Brian Patrick, Robert Hostoffer, and Theodore Sher. "Non-IgE Food Immunological Diseases." In Allergy and Asthma, 1–8. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-58726-4_27-1.

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Peppers, Brian Patrick, Robert Hostoffer, and Theodore Sher. "Non-IgE Food Immunological Diseases." In Allergy and Asthma, 593–600. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-05147-1_27.

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Тези доповідей конференцій з теми "Food allergy, asthma, allergenes"

Akkerman, J. W. N., E. Kloprogge, and P. L. B. Bruynzeel. "PLATELETS PLAY A ROLE IN THE IMMEDIATE ALLERGEN-INDUCED BRONCHOCONSTRICTIVE REACTION IN ASTHMATICS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642880.

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Platelet Activating Factor (PAF) is generally considered to play an important role in acute allergic reactions. A special example of such a reaction is allergic asthma and indirect evidence suggests that here too PAF may be involved. Direct proof for a role of PAF, however, is difficult to obtain since in blood PAF has an extremely short half-life due to its inactivation by an acetyl-hydrolase in plasma, its uptake and degradation by many cell types and its lipophilic properties making it easily stick to membranes. Despite these handicaps we report here that during an acute bronchoconstrictive reaction in asthmatics, PAF is liberated into the circulation and binds to platelets. Eight patients with allergic asthma were challenged by inhalation provocation. Four patients responded with an immediate bronchoconstrictive reaction, which was accompanied by a 40% decrease in freely accessible PAF-receptors on their platelets, collected 1 hour after bronchoconstriction (specific bindings of 3H-PAF decreased from 264 ± 44 to 164 ± 45 mol/platelet, p < 0.05). The patients who did qpt respond to allergen provocation failed to show a change in 3H-PAF binding. In both groups platelet counts and PAF-induced aggregation did not change significantly. In view of the high specificity of PAF-receptors on platelets (a 200-fold excess of histamine did not interfere) and the fact that in vitro3H-PAF-binding gradually becomes irreversible, we conclude that during an immediate bronchoconstrictive reaction circulating platelets make contact with PAF. Together with evidence that urtder similar conditions secreted products from platelets appear in the circulation, these data indicate that platelet activation by PAF forms an important step in the pathophysiology of allergic asthma.

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Bittner, Cordula, Alexandra Marita Preisser, and Volker Harth. "Occupational Asthma due to Food Allergy in a Madagascan Cook." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa1219.

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Wong, GW, M. Yu, J. Li, YZ Chen, NS Zhong, TF Leung, and KY Liu. "The Relationship of Allergic Sensitization to Aero-Allergens and Food Allergens and Asthma Symptoms in Urban and Rural Chinese Schoolchildren." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3969.

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Smirnova, Svetlana, Anna Barilo, and Irina Borisova. "Food allergy and asthma in children from the Eastern Siberia of Russia." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa2735.

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Звіти організацій з теми "Food allergy, asthma, allergenes"

Obbagy, Julie, Laural English, Tricia Psota, Perrine Nadaud, Kirsten Johns, Yat Ping Wong, Nancy Terry, et al. Types and Amounts of Complementary Foods and Beverages and Food Allergy, Atopic Dermatitis/Eczema, Asthma, and Allergic Rhinitis: A Systematic Review. U.S. Department of Agriculture, Food and Nutrition Service, Center for Nutrition Policy and Promotion, Nutrition Evidence Systematic Review, April 2019. http://dx.doi.org/10.52570/nesr.pb242018.sr0304.

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Obbagy, Julie, Laural English, Tricia Psota, Perrine Nadaud, Kirsten Johns, Yat Ping Wong, Nancy Terry, et al. Timing of Introduction of Complementary Foods and Beverages and Food Allergy, Atopic Dermatitis/Eczema, Asthma, and Allergic Rhinitis: A Systematic Review. U.S. Department of Agriculture, Food and Nutrition Service, Center for Nutrition Policy and Promotion, Nutrition Evidence Systematic Review, April 2019. http://dx.doi.org/10.52570/nesr.pb242018.sr0303.

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