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Добірка наукової літератури з теми "Flavonoids, chronic respiratory diseases"

Автор: Grafiati

Опубліковано: 11 березня 2023

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Статті в журналах з теми "Flavonoids, chronic respiratory diseases"

Oršolić, Nada. "Allergic Inflammation: Effect of Propolis and Its Flavonoids." Molecules 27, no. 19 (October 8, 2022): 6694. http://dx.doi.org/10.3390/molecules27196694.

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The incidence of allergic diseases and their complications are increasing worldwide. Today, people increasingly use natural products, which has been termed a “return to nature”. Natural products with healing properties, especially those obtained from plants and bees, have been used in the prevention and treatment of numerous chronic diseases, including allergy and/or inflammation. Propolis is a multi-component resin rich in flavonoids, collected and transformed by honeybees from buds and plant wounds for the construction and adaptation of their nests. This article describes the current views regarding the possible mechanisms and multiple benefits of flavonoids in combating allergy and allergy-related complications. These benefits arise from flavonoid anti-allergic, anti-inflammatory, antioxidative, and wound healing activities and their effects on microbe-immune system interactions in developing host responses to different allergens. Finally, this article presents various aspects of allergy pathobiology and possible molecular approaches in their treatment. Possible mechanisms regarding the antiallergic action of propolis on the microbiota of the digestive and respiratory tracts and skin diseases as a method to selectively remove allergenic molecules by the process of bacterial biotransformation are also reported.

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Bora, Alina, Liliana Pacureanu, and Luminita Crisan. "In Silico Study of Some Natural Flavonoids as Potential Agents against COVID-19: Preliminary Results." Chemistry Proceedings 3, no. 1 (November 14, 2020): 25. http://dx.doi.org/10.3390/ecsoc-24-08343.

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Flavonoids, widely distributed in fruits, vegetables, and medicinal herbs, are compounds with multiple biological benefits to human health from anti-inflammatory, antioxidant, anticancer, antibacterial to antiviral activity. Coronavirus disease 2019 (COVID-19), a serious concern in the world today, is a respiratory tract disease involving moderate to severe symptoms of pneumonia, with a major incidence in older people and patients having chronic diseases. This emergency health situation led us to evaluate the possible use of natural products to prevent respiratory diseases. The present study aims to report the potential of four natural flavonoids, known to have anti-inflammatory and antiviral activity, as anti-SARS-CoV-2 through their binding on the 6YNQ protein receptor. Molecular docking study with the FRED program was chosen as an appropriate tool to analyze the interaction of natural flavonoids, quercetin, luteolin, galangin, and naringenin, with the SARS-CoV-2 main protease and to rank the conformations through a scoring function to predict their binding affinity. Overall, our preliminary results indicate the potential of the titled natural flavonoids to fight the new coronavirus, COVID-19.

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Mattioli, Veronica, Maria Elisabetta Zanolin, Lucia Cazzoletti, Roberto Bono, Isa Cerveri, Marcello Ferrari, Pietro Pirina, and Vanessa Garcia-Larsen. "Dietary flavonoids and respiratory diseases: a population-based multi-case–control study in Italian adults." Public Health Nutrition 23, no. 14 (January 30, 2020): 2548–56. http://dx.doi.org/10.1017/s1368980019003562.

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AbstractObjective:To analyse the associations between chronic respiratory diseases and intakes of total flavonoids and their major subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, polymers and proanthocyanidins).Design:Multi-case–control study.Setting:The analysis was conducted in the frame of the Genes Environment Interaction in Respiratory Diseases (GEIRD) study. The European Prospective Investigation into Cancer and Nutrition FFQ was used to ascertain dietary intake. Multinomial regression models adjusting for age, sex, centre, BMI, smoking habit, alcohol intake, education, total energy intake, vitamin C intake and total fruit intake were used to examine the associations between dietary exposures and the relative risk ratio (RRR) of being a case.Participants:Individuals (n 990) hierarchically defined as follows: cases with asthma (current, n 159; past, n 78), chronic bronchitis (n 47), rhinitis (allergic rhinitis, n 167; non-allergic rhinitis, n 142) and controls (n 97).Results:An increase of 1 sd in flavanones was associated with a reduced risk of non-allergic rhinitis (adjusted RRR = 0·68, 95 % CI 0·47, 0·97); a similar result was found comparing the highest v. lowest quartile of flavanones intake (adjusted RRR = 0·24, 95 % CI 0·10, 0·59).Conclusions:Flavonoids contained in fruits and vegetables, especially flavanones, might reduce the risk of non-allergic rhinitis. No associations were found between other flavonoids and the considered outcomes.

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Fu, Yaw-Syan, Ning Kang, Yanping Yu, Yan Mi, Jialin Guo, Jingyi Wu, and Ching-Feng Weng. "Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD." European Respiratory Review 31, no. 164 (June 14, 2022): 220028. http://dx.doi.org/10.1183/16000617.0028-2022.

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COPD is predicted to become the third leading cause of morbidity and mortality worldwide by 2030. Cigarette smoking (active or passive) is one of its chief causes, with about 20% of cigarette smokers developing COPD from cigarette smoke (CS)-induced irreversible damage and sustained inflammation of the airway epithelium. Inflammasome activation leads to the cleavage of pro-interleukin (IL)-1β and pro-IL-18, along with the release of pro-inflammatory cytokines via gasdermin D N-terminal fragment membrane pores, which further triggers acute phase pro-inflammatory responses and concurrent pyroptosis. There is currently intense interest in the role of nucleotide-binding oligomerisation domain-like receptor family, pyrin domain containing protein-3 inflammasomes in chronic inflammatory lung diseases such as COPD and their potential for therapeutic targeting. Phytochemicals including polyphenols and flavonoids have phyto-medicinal benefits in CS-COPD. Here, we review published articles from the last decade regarding the known associations between inflammasome-mediated responses and ameliorations in pre-clinical manifestations of CS-COPD via polyphenol and flavonoid treatment, with a focus on the underlying mechanistic insights. This article will potentially assist the development of drugs for the prevention and therapy of COPD, particularly in cigarette smokers.

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Santana, Fernanda Paula R., Nathalia M. Pinheiro, Márcia Isabel B. Mernak, Renato F. Righetti, Mílton A. Martins, João H. G. Lago, Fernanda D. T. Q. dos Santos Lopes, Iolanda F. L. C. Tibério, and Carla M. Prado. "Evidences of Herbal Medicine-Derived Natural Products Effects in Inflammatory Lung Diseases." Mediators of Inflammation 2016 (2016): 1–14. http://dx.doi.org/10.1155/2016/2348968.

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Pulmonary inflammation is a hallmark of many respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and acute respiratory syndrome distress (ARDS). Most of these diseases are treated with anti-inflammatory therapy in order to prevent or to reduce the pulmonary inflammation. Herbal medicine-derived natural products have been used in folk medicine and scientific studies to evaluate the value of these compounds have grown in recent years. Many substances derived from plants have the biological effectsin vitroandin vivo, such as flavonoids, alkaloids, and terpenoids. Among the biological activities of natural products derived from plants can be pointed out the anti-inflammatory, antiviral, antiplatelet, antitumor anti-allergic activities, and antioxidant. Although many reports have evaluated the effects of these compounds in experimental models, studies evaluating clinical trials are scarce in the literature. This review aims to emphasize the effects of these different natural products in pulmonary diseases in experimental models and in humans and pointing out some possible mechanisms of action.

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Hidanah, Sri, Emy Koestanti Sabdoningrum, Retno Sri Wahjuni, and Arimbi Arimbi. "Implementation of Meniran Extract (Phyllanthus Niruri Linn) on the Performance of Broiler Chickens Infected by Mycoplasma gallisepticum Caused Chronic Respiratory Disease." KnE Life Sciences 3, no. 6 (December 3, 2017): 296. http://dx.doi.org/10.18502/kls.v3i6.1138.

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Chronic respiratory disease (CRD) of chicken is a disease that has great economic losses in poultry industry in the world. The losses are mainly due to the decrease of body weight gain, feed efficiencies, hatchabilities and increase conversion of the feed, of embryo mortality. The main causative agent of Chronic Respiratory Disease (CRD) is Mycoplasma gallisepticum. Mycoplasma gallisepticum attacks the respiratory tract, especially in young broiler chickens with age ranged 3-5 weeks. CRD treatment usually uses macrolide antibiotics, because it has proven effective to inhibit protein synthesis. However, it is not recommended to continuously given because the chicken can be resistant to the medicineand leave a harmful reside to consumers. The development of herbal medicine utilization currently is mostly implemented for the treatment of diseases that infected livestock. Meniran plants (Phyllanthus niruri Linn) is one of the plants that can be used as prevention and alternative treatment caused by Chronic Respiratory Disease (CRD). Meniran (Phyllanthus niruri Linn) has the content of bioactive compounds that have antibacterial activity, including terpenoids,alkaloids, flavonoids, saponins, and tannins. The purpose of this study is to test and evaluate the effectiveness of Meniran extract (Phyllanthus Niruri Linn) on the performance of broiler chickens infected by Chronic Respiratory Disease (CRD), seen from the feed conversion.Keywords: Meniran, Mycoplasma galisepticum, Chronic Respiratory Disease (CRD), performance of Broiler Chickens, Feed Conversion

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Zullkiflee, Nadzirah, Hussein Taha, and Anwar Usman. "Propolis: Its Role and Efficacy in Human Health and Diseases." Molecules 27, no. 18 (September 19, 2022): 6120. http://dx.doi.org/10.3390/molecules27186120.

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With technological advancements in the medicinal and pharmaceutical industries, numerous research studies have focused on the propolis produced by stingless bees (Meliponini tribe) and Apis mellifera honeybees as alternative complementary medicines for the potential treatment of various acute and chronic diseases. Propolis can be found in tropical and subtropical forests throughout the world. The composition of phytochemical constituents in propolis varies depending on the bee species, geographical location, botanical source, and environmental conditions. Typically, propolis contains lipid, beeswax, essential oils, pollen, and organic components. The latter include flavonoids, phenolic compounds, polyphenols, terpenes, terpenoids, coumarins, steroids, amino acids, and aromatic acids. The biologically active constituents of propolis, which include countless organic compounds such as artepillin C, caffeic acid, caffeic acid phenethyl ester, apigenin, chrysin, galangin, kaempferol, luteolin, genistein, naringin, pinocembrin, coumaric acid, and quercetin, have a broad spectrum of biological and therapeutic properties such as antidiabetic, anti-inflammatory, antioxidant, anticancer, rheumatoid arthritis, chronic obstruct pulmonary disorders, cardiovascular diseases, respiratory tract-related diseases, gastrointestinal disorders, as well as neuroprotective, immunomodulatory, and immuno-inflammatory agents. Therefore, this review aims to provide a summary of recent studies on the role of propolis, its constituents, its biologically active compounds, and their efficacy in the medicinal and pharmaceutical treatment of chronic diseases.

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Koss-Mikołajczyk, Izabela, Monika Baranowska, Vanja Todorovic, Adriana Albini, Clementina Sansone, Pierre Andreoletti, Mustapha Cherkaoui-Malki, et al. "Prophylaxis of Non-communicable Diseases: Why Fruits and Vegetables may be Better Chemopreventive Agents than Dietary Supplements Based on Isolated Phytochemicals?" Current Pharmaceutical Design 25, no. 16 (August 23, 2019): 1847–60. http://dx.doi.org/10.2174/1381612825666190702093301.

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The World Health Organization (WHO) report from 2014 documented that non-communicable socalled civilization diseases such as cardiovascular disease, chronic respiratory diseases, cancer or type 2 diabetes are responsible for over 50% of all premature deaths in the world. Research carried out over the past 20 years has provided data suggesting that diet is an essential factor influencing the risk of development of these diseases. The increasing knowledge on chemopreventive properties of certain food ingredients, in particular, those of plant origin, opened the discussion on the possibility to use edible plants or their active components in the prevention of these chronic diseases. Health-promoting properties of plant foods are associated with the presence of secondary metabolites that can affect many biological mechanisms of critical importance to the proper functioning of the human organism. Particularly, there have been numerous investigations indicating strong physiological effects of bioactive plant phenols belonging to the flavonoid family. These observations initiated mass production of dietary supplements containing flavonoids commercialized under the name antioxidants, even if their chemical properties did not justify such a term. However, epidemiological studies revealed that isolated bioactive phytochemicals are not as effective as fruits and vegetables containing these substances whereas they are of interest of the functional food industry. In this paper, the critical assessment of reasons for this turn of events has been attempted and the concept of food synergy has been suggested as a future strategy of dietary chemoprevention.

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Reddy, Amala, and Sujatha Sundaresan. "PHYTOCHEMICAL ANALYSIS AND SUPPRESSION OF INFLAMMATORY TARGETS BY ADATHODA VASICA." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (May 1, 2018): 162. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.24243.

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Objectives: A persistent and chronic inflammation may act as an underlying definition for many of the long-term illness such as diabetic foot ulcer, Alzheimer’s disease and rheumatoid arthritis. Folklore medicinal plants provide immense health benefits with new remedies. Active compounds from plants containing alkaloids and phenolic compounds (flavonoids and tannins) possess antioxidant and anti-inflammatory activity. The leaves of Adhatoda vasica are most known for its effectiveness in treating respiratory diseases such as asthma, chronic bronchitis, and other respiratory conditions. In this report, we investigated the possible action of A. vasica against inflammation.Methods: Solvents with varying polarity (Hexane, dichloromethane, ethyl acetate, and methanol) were used for the sequential extraction of leaves of A. vasica Linn (Family: Acanthaceae). The anti‐inflammatory activity was assessed using simple in vitro methods. Phenols, flavonoids, phytosterols, saponins, alkaloids, and tannins were analyzed qualitatively using standard protocols. Anti‐inflammatory activity was evaluated using albumin denaturation assay, membrane stabilization assay and proteinase inhibitory activity. Aspirin (diclofenac) was used as a standard drug for the study of anti-inflammatory activity.Results: Our results substantiated that methanolic extract of A. vasica gave a maximum yield of 12.5% and apparently all bioactive phytochemical constituents were at a higher concentration in the methanolic extract. Methanolic extract of A. vasica showed a significant inhibition of the heat-induced albumin denaturation, red blood cells membrane stabilization, and proteinase inhibitory effects with 86±1.46, 88±1.24, and 96±0.93% for 1000 μg/ml, respectively.Conclusion: The above results delineate that the bioactive components were extracted using high polar solvent are mostly flavonoids and related polyphenols. These compounds may be the active constituents to render the anti-inflammatory activity to A. vasica.

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Wahab, Shadma, Sivakumar Annadurai, Shahabe Saquib Abullais, Gotam Das, Wasim Ahmad, Md Faruque Ahmad, Geetha Kandasamy, Rajalakshimi Vasudevan, Md Sajid Ali, and Mohd Amir. "Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology." Plants 10, no. 12 (December 14, 2021): 2751. http://dx.doi.org/10.3390/plants10122751.

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There are more than 30 species of Glycyrrhiza genus extensively spread worldwide. It was the most prescribed herb in Ancient Egyptian, Roman, Greek, East China, and the West from the Former Han era. There are various beneficial effects of licorice root extracts, such as treating throat infections, tuberculosis, respiratory, liver diseases, antibacterial, anti-inflammatory, and immunodeficiency. On the other hand, traditional medicines are getting the attraction to treat many diseases. Therefore, it is vital to screen the medicinal plants to find the potential of new compounds to treat chronic diseases such as respiratory, cardiovascular, anticancer, hepatoprotective, etc. This work comprehensively reviews ethnopharmacological uses, phytochemistry, biological activities, clinical evidence, and the toxicology of licorice, which will serve as a resource for future clinical and fundamental studies. An attempt has been made to establish the pharmacological effect of licorice in different diseases. In addition, the focus of this review article is on the molecular mechanism of licorice extracts and their four flavonoids (isoliquiritigenin, liquiritigenin, lichalocone, and glabridin) pharmacologic activities. Licorice could be a natural alternative for current therapy to exterminate new emerging disorders with mild side effects. This review will provide systematic insights into this ancient drug for further development and clinical use.

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Дисертації з теми "Flavonoids, chronic respiratory diseases"

Cantero, Recasens Gerard 1984. "Cellular Ca2+ homeostasis in the pathophysiology of chronic respiratory diseases." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/104537.

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Calcium works as a second intracellular messenger in all cell types and its downstream signalling is a key pathway for many systemic functions. In the lungs, the majority of activating stimuli trigger intracellular calcium increase, which is indispensable for the normal functioning of the airways; thus, deregulation of this pathway leads to pathological conditions. This Thesis aims to understand the relationship of intracellular calcium homeostasis and chronic respiratory pathologies such as asthma. I have studied three different processes involved in calcium homeostasis and their role in asthma pathophysiology: 1) I have shown the genetic association of a defect in calcium entry via TRPV1 with wheezing and cough, which is one feature of asthma pathophysiology; 2) I have also demonstrated the product of the asthma associated ORMDL3 gene is a Ca++ homeostasis and UPR modulator; and 3) I have provided a new Ca++ dependent sorting mechanism for secretory cargoes that bind calcium.
El Calci és un segon missatger intracel·lular en tots els tipus cel·lulars i la cascada de senyalització generada pel calci és una via de senyalització cel·lular clau per moltes funcions sistèmiques. En els pulmons, la majoria d’estímuls activadors produeixen un increment del calci intracel·lular, el qual és indispensable pel funcionament correcte de les vies respiratòries; i, per tant, una desregulació d’aquesta via de senyalització porta a diferents situacions patològiques. Aquesta Tesi té com a objectiu entendre la relació entre l’homeòstasi del calci intracel·lular i les malalties respiratòries cròniques, com per exemple, l’asma. Hem estudiat tres processos diferents implicats en l’homeòstasi del calci i el seu rol en la fisiopatologia de l’asma: 1) Hem demostrat que hi ha una associació genètica entre un defecte en l’entrada de calci via TRPV1 i un dels trets característics de l’asma, la tos; 2) també hem trobat que l’ORMDL3, que havia estat associat amb l’asma, és un modulador de l’homeòstasi del calci i de la UPR; i 3) hem aportat un nou mecanisme de classificació en el Golgi depenent de Ca++ per a proteïnes que uneixen calci i que seran secretades.

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Chu, Thi Ha. "Phenotyping of chronic respiratory diseases in the South of Vietnam." Doctoral thesis, Universite Libre de Bruxelles, 2019. https://dipot.ulb.ac.be/dspace/bitstream/2013/288355/4/coverpage.pdf.

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Chronic respiratory diseases (CRDs) include chronic diseases involving the airways and other structures of the lung. In the current circumstance of Vietnam, people are exposed to numerous risk factors of CRD, such as heavy smoking, high frequency of pulmonary tuberculosis, chronic helminthiasis, allergic factors, migration and urbanization (the last associated with traffic-related pollution). The phenotype diagnoses should take into account the risk factors of each individual besides the clinical features, while the differential diagnoses mostly depend on the available techniques in each healthcare center. Our aim was to improve the differential diagnoses of the 3 most frequent CRDs: chronic obstructive pulmonary disease (COPD), asthma and COPD – asthma overlap syndrome (ACOS), in Vietnam. In the first part, we evaluated the prevalence of the allergen sensitization among patients with CRD, in regard to the urban and rural area in the South of Vietnam. House dust mites and cockroach droppings were the most frequent sensitizer. Compared with participants born in the urban setting, those born in the rural environment were less frequently sensitized and this protective effect disappeared in the case of migration from rural to urban areas. In the second part, we evaluated skin prick test as a method to screen dust mite sensitization in CRD in southern Vietnam. The data suggested that, in the present circumstance, skin prick test can be used to screen mite sensitization. In the third part, we evaluated the risk of mite sensitization in the native and migrant population, in regard to several environmental factors. Consistently with the hygiene hypothesis, compared to urban, exposure to high endotoxin concentration in rural was a protective factor against allergic sensitization. We reported for the first time that this effect was reversible among the migrants from rural to urban setting in association with lower endotoxin exposure. In the fourth part, we have defined asthma, COPD and ACOS based on clinical symptoms, cumulative smoking and airway expiratory flow with reversibility, on one side, and the age-related of the different phenotypes, on the other side. We hypothesized that the cumulative exposure to noxious particles should increase the age-related prevalence of COPD, while due to the immunosenescence process, the prevalence of IgE-mediated asthma should decrease with age, and ACOS prevalence being not related to age due to the combined mechanisms. In conclusion, we showed in the South of Vietnam that:1) mites and cockroach allergens were the most frequent sensitizer in chronic respiratory diseases;2) the skin prick test to mite has been validated to screen mite sensitization;3) associated with a reduced level of endotoxin level, migration from rural to the urban setting was a risk factor of mite sensitization in chronic respiratory diseases;4) based on the clinical symptoms, spirometric values, and cumulative smoking, the diagnosis of asthma, COPD and ACOS have been made and their prevalence were 25, 42 and 33%, respectively.
Doctorat en Sciences biomédicales et pharmaceutiques (Médecine)
info:eu-repo/semantics/nonPublished

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Baril, Jacinthe. "Interaction between circulatory and respiratory exercise adaptation in chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF)." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97901.

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Chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) patients show a marked reduction in exercise capacity compared to that of healthy age-matched individuals. While inadequate gas exchange and resulting hypoxemia appears as the primary factor in COPD, an impaired cardiac output is the predominant explanation for the reduced oxygen delivery in CHF. However, the extent of the contributions of other systemic factors remains unclear. In light of the potential interactions between cardiac output (Qc) and pulmonary hyperinflation, there is surprisingly little data thus far on ventilatory constraints in CHF and on the role of blood flow delivery in COPD which may further limit the exercise capacity. Thus, the purpose of this study was to compare the slope of the Qc versus oxygen uptake (VO2) response through several submaximal cycling loads in patients with moderately severe COPD and with that of moderate to severe CHF patients as well as age-matched healthy control subjects (CTRL). Also examined was the possibility that ventilatory constraints such as dynamic hyperinflation contribute to an abnormal stroke volume response in both diseases. Cardiac output was measured using the CO 2-rebreathing equilibrium technique during baseline conditions and cycling at 20, 40 and 65% of peak power in 17 COPD (Age: 64 +/- 8 yrs; FEV 1/FVC: 37 +/- 11%; FEV1: 41 +/- 15 % predicted), 10 CHF (Age: 57+/- 10 yrs; FEV1/FVC: 73.8 +/- 5.6%; FEV 1: 93 +/- 13% predicted) and 10 age-matched CTRL subjects. Inspiratory capacity (IC) was also measured for the determination of dynamic hyperinflation during the steady state exercise bouts. The results indicate that while the absolute Qc values are lower in COPD and in CHF than in CTRL during 65% peak power cycling (11.30 +/- 2.38 vs 12.40 +/- 2.08 vs 15.63 +/- 2.15 L•min-1 respectively, p < 0.01), likely due to their lower exercise metabolic demand. The Qc/VO2 response to increasing levels of exercise intensity was lower or normal in CHF patients compared to CTRL, while normal or hyperdynamic in most COPD patients. Indeed, the majority of patients with COPD exhibited Qc/VO2 slopes greater than 7.0, which may be indicative of a peripheral muscle bioenergetic disturbance that may drive the need for greater oxygen delivery, and thus result in an exaggerated central circulatory response.

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Messaggi-Sartor, Monique 1984. "Respiratory muscle dysfunction in respiratory and non-respiratory diseases : clinical and therapeutic approaches." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/565809.

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Respiratory muscle dysfunction is a clinical condition that may be present in both respiratory and non-respiratory diseases. This impairment of muscle function can have a negative effect on clinical outcomes, contributing to a further worsening of the patient’s clinical condition. This doctoral thesis has been directed by the ‘Rehabilitation Research Group’ (RERG) in collaboration with the Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer Group (Lung Cancer and Muscle Research Group) of the Institut Hospital del Mar d’Investigacions Mèdiques (IMIM) in Barcelona. Muscle dysfunction has been a priority area of research in these groups from different perspectives: exercise and muscle training in the RERG, Physiopathology and Molecular Biology in the Lung Cancer and Muscle Research Group. The large number of published studies in journals with high impact factor endorses the quality and leadership of these research groups. Up to then, research on RMT had focused on patients with chronic obstructive pulmonary disease, but had been scarcely addressed in other conditions. In the last 5 years, the RERG has aimed to study the effects of RMT in other respiratory diseases (bronchiectasis, lung cancer) and in non-respiratory diseases. The study of respiratory muscle dysfunction in stroke patients has made it possible to start an increasing collaboration with neurorehabilitation researchers, in which RMT plays a role in the management of patients with dysphagia.
La disfunción muscular respiratoria es una condición clínica que puede estar presente tanto en las enfermedades respiratorias como no respiratorias. Este deterioro de la función muscular puede tener un efecto negativo en los resultados clínicos, lo que contribuye a un mayor empeoramiento de la condición clínica del paciente. Esta tesis doctoral ha sido dirigida por el "Grupo de Investigación en Rehabilitación" (RERG) en colaboración con el Grupo de Investigación de Enfermedades Respiratorias Crónicas y Cáncer de Pulmón (Grupo de Investigación de Cáncer de Pulmón y Músculo) del Instituto Hospital del Mar de Investigaciones Mèdiques (IMIM) en Barcelona. La disfunción muscular ha sido un área prioritaria de investigación en estos grupos desde diferentes perspectivas: ejercicio y entrenamiento muscular en el RERG, Fisiopatología y Biología Molecular en el Cáncer de Pulmón y el Grupo de Investigación Muscular. El gran número de estudios publicados en revistas con alto factor de impacto refuerza la calidad y liderazgo de estos grupos de investigación. Hasta entonces, la investigación sobre RMT se había centrado en los pacientes con enfermedad pulmonar obstructiva crónica, pero apenas se había abordado en otras condiciones. En los últimos 5 años, el RERG se ha propuesto estudiar los efectos de la RMT en otras enfermedades respiratorias (bronquiectasias, cáncer de pulmón) y en enfermedades no respiratorias. El estudio de la disfunción de los músculos respiratorios en los pacientes con ictus ha permitido iniciar una creciente colaboración con los investigadores de neurorehabilitación, en los que RMT desempeña un papel en el tratamiento de los pacientes con disfagia.

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Koo, Sergio Don. "Quality of life in children with chronic allergic respiratory disease a population-based child health survey in Hong Kong /." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42931538.

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Cook, Arlene Jane. "The role of leukotrienes in diseases causing chronic airway obstruction in children." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244248.

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Mazzucato, Roberta <1988&gt. "Design and Synthesis of Novel Kinase Inhibitors for the Treatment of Chronic Respiratory Diseases." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amsdottorato.unibo.it/9617/1/Mazzucato_Roberta_Tesi.pdf.

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In 2017, Chronic Respiratory Diseases accounted for almost four million deaths worldwide. Unfortunately, current treatments are not definitive for such diseases. This unmet medical need forces the scientific community to increase efforts in the identification of new therapeutic solutions. PI3K delta plays a key role in mechanisms that promote airway chronic inflammation underlying Asthma and COPD. The first part of this project was dedicated to the identification of novel PI3K delta inhibitors. A first SAR expansion of a Hit, previously identified by a HTS campaign, was carried out. A library of 43 analogues was synthesised taking advantage of an efficient synthetic approach. This allowed the identification of an improved Hit of nanomolar enzymatic potency and moderate selectivity for PI3K delta over other PI3K isoforms. However, this compound exhibited low potency in cell-based assays. Low cellular potency was related to sub optimal phys-chem and ADME properties. The analysis of the X-ray crystal structure of this compound in human PI3K delta guided a second tailored SAR expansion that led to improved cellular potency and solubility. The second part of the thesis was focused on the rational design and synthesis of new macrocyclic Rho-associated protein kinases (ROCKs) inhibitors. Inhibition of these kinases has been associated with vasodilating effects. Therefore, ROCKs could represent attractive targets for the treatment of pulmonary arterial hypertension (PAH). Known ROCK inhibitors suffer from low selectivity across the kinome. The design of macrocyclic inhibitors was considered a promising strategy to obtain improved selectivity. Known inhibitors from literature were evaluated for opportunities of macrocyclization using a knowledge-based approach supported by Computer Aided Drug Design (CADD). The identification of a macrocyclic ROCK inhibitor with enzymatic activity in the low micro molar range against ROCK II represented a promising result that validated this innovative approach in the design of new ROCKs inhibitors.

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Sidani, Souraya 1960. "Effects of sedative music on the respiratory status of clients with chronic obstructive airways diseases." Thesis, The University of Arizona, 1991. http://hdl.handle.net/10150/277959.

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A quasi-experimental, pre-test post-test study was conducted to examine the effects of sedative music on the perception of dyspnea intensity, respiratory rate, pulse rate and oxyhemoglobin saturation level of clients with Chronic Obstructive Airway Disease (COAD). Data was collected on a convenience sample of 10 subjects who acted as their own control. After a six minutes walk, each subject was randomly exposed to a treatment (listening to music for 20 minutes) and to a control (resting for 20 minutes) situation. A series of paired t-tests was performed to analyze the data. Results indicated that the mean pulse rate and mean respiratory rate were significantly lower after listening to music than after resting only. Correlational analysis indicated that the perceived intensity of dyspnea is positively correlated with pulse and respiratory rates, and negatively correlated with oxygen saturation level. Encouraging clients with COAD to listen to music is a supplemental nursing intervention aiming at reducing dyspnea perception, pulse and respiratory rates.

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古修齊 and Sergio Don Koo. "Quality of life in children with chronic allergic respiratory disease: a population-based child health survey inHong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42931538.

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Veeranki, Sreenivas P., Shimin Zheng, Yan Cao, and Arsham Alamian. "Association of Serum Vitamin D Levels with Respiratory and Atopic Diseases." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/91.

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Background: Vitamin D is known to be associated with inflammatory diseases, but its relationship with allergic diseases is unclear. The study objective is to determine the association of serum vitamin D levels and markers of wheeze, asthma and atopy. Methods: Data (n = 9,463) on serum vitamin D levels and atopy were obtained from 2005-2006 National Health and Nutrition Examination Survey. Serum vitamin D level was categorized into four groups: Normal (≥30ng/ml), Insufficient (21-29ng/ml), Deficient (11-20ng/ml) and Severely Deficient (≤10ng/ml). Atopy was defined as at least 1 positive allergen-specific IgE level measured for a panel of 5 common aeroallergens- cat, dog, house dust mite, cock roach and Alternaria species. Doctor-diagnosed asthma and wheeze in the previous 12 months were assessed by means of questionnaire. Multivariable logistic regression analyses were conducted to investigate the association of serum vitamin D with wheeze, asthma and atopy adjusting for age, sex, race, smoking, outdoor physical activity, body mass index and poverty income ratio. Results: Overall, 15%, 14% and 28% of subjects had wheeze, asthma and atopy, respectively. Approximately 21% had normal serum vitamin D levels, while 35%, 28% and 5% had insufficient, deficient and severely deficient levels. Compared to subjects with normal vitamin D levels, those with insufficient, deficient and severely deficient levels had increased relative odds of wheeze and atopy with highest adjusted estimates in subjects with severe vitamin D deficiency (adjusted odds ratio [OR] 2.31, 95% Confidence Interval [CI] 1.73-3.10 for wheeze; OR 1.49, 95% CI 1.17-1.89 for atopy). Conclusion: Low serum vitamin D levels were found to be associated with wheeze and atopy. Findings contribute to ongoing efforts to understanding the role of vitamin D in atopic diseases.

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Книги з теми "Flavonoids, chronic respiratory diseases"

Williams, Simon J. Chronic Respiratory Illness. London: Taylor & Francis Group Plc, 2004.

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Chronic respiratory illness. London: Routledge, 1993.

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West Virginia. Bureau of Public Health., ed. Chronic lower respiratory disease: A state and national problem. [Charleston, W.Va.]: West Virginia Bureau for Public Health, 2003.

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Acute exacerbation of respiratory diseases. New Delhi: Jaypee Brothers Medical Publishers, 2012.

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Workshop "Respiratory Muscles in C.O.P.D." (1986 Montescano, Italy). Respiratory muscles in chronic obstructive pulmonary disease. London: Springer-Verlag, 1987.

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Jean-Philippe, Derenne, Similowski Thomas 1961-, and Whitelaw William A. 1941-, eds. Acute respiratory failure in chronic obstructive pulmonary disease. New York: M. Dekker, 1996.

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Min, Kon Onn, Hansel T. T. 1956-, and Barnes Peter J. 1946-, eds. Chronic obstructive pulmonary disease: (COPD). Oxford: Oxford University Press, 2008.

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Min, Kon Onn, Hansel T. T. 1956-, and Barnes Peter J. 1946-, eds. Chronic obstructive pulmonary disease: (COPD). Oxford: Oxford University Press, 2008.

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Sharafkhaneh, Amir, Abebaw Mengistu Yohannes, Nicola A. Hanania, and Mark E. Kunik, eds. Depression and Anxiety in Patients with Chronic Respiratory Diseases. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7009-4.

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Welfare, Australian Institute of Health and. Chronic respiratory diseases in Australia: Their prevalence, consequences and prevention. Canberra: AIHW, 2005.

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Billo, Nils E., Nick Banatvala, Pascal Bovet, and Asma El Sony. "Chronic respiratory diseases." In Noncommunicable Diseases, 118–24. London: Routledge, 2023. http://dx.doi.org/10.4324/9781003306689-18.

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Jariwalla, G. "Chronic bronchitis and emphysema." In Respiratory Diseases, 59–72. Dordrecht: Springer Netherlands, 1985. http://dx.doi.org/10.1007/978-94-009-4880-8_5.

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Jariwalla, G. "Chronic infections of the lungs." In Respiratory Diseases, 181–94. Dordrecht: Springer Netherlands, 1985. http://dx.doi.org/10.1007/978-94-009-4880-8_12.

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Astudillo Maggio, Claudia, Patricio Barañao Garcés, and Mireya Méndez Raggi. "Chronic Invasive Ventilation." In Pediatric Respiratory Diseases, 697–704. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-26961-6_68.

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Barja Yáñez, Salesa. "Nutrition in Chronic Respiratory Disease." In Pediatric Respiratory Diseases, 579–90. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-26961-6_57.

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Moya Isamitt, Ana. "Nursing Care Education in Chronic Respiratory Diseases." In Pediatric Respiratory Diseases, 605–21. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-26961-6_59.

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Méndez Raggi, Mireya, and Claudia Astudillo Maggio. "Prolonged Hospitalization Due to Chronic Respiratory Diseases." In Pediatric Respiratory Diseases, 669–74. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-26961-6_65.

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Torres Castro, Rodrigo, Homero Puppo Gallardo, and Daniel Zenteno Araos. "Pulmonary Rehabilitation in Children with Chronic Respiratory Diseases." In Pediatric Respiratory Diseases, 661–68. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-26961-6_64.

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Vellingiri, Vigneshwaran, Prabhu Thirusangu, and Inshah Din. "Acute Respiratory Distress Syndrome: Therapeutics, Pathobiology, and Prognosis." In Chronic Lung Diseases, 143–56. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-3734-9_7.

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Zamarrón, Carlos, Emilio Morete, and Francisco Gonzalez. "Telenursing in Chronic Respiratory Diseases." In Health Informatics, 107–18. London: Springer London, 2011. http://dx.doi.org/10.1007/978-0-85729-529-3_10.

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Тези доповідей конференцій з теми "Flavonoids, chronic respiratory diseases"

Fukuda, Yosuke, Shintaro Suzuki, Tetsuya Homma, and Hironori Sagara. "High burden ofA. fumigatusamong chronic respiratory diseases." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa5022.

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Vitacca, Michele, Marilena Barbisoni, Laura Comini, Gloria Francolini, and Mara Paneroni. "Pulmonary rehabilitation appropriateness triage in chronic respiratory diseases." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa681.

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Zanolin, M. Elisabetta, Liliya Chamitava, Paolo Degan, Andrea Pasini, Anna Fratta-Pasini, Morena Nicolis, Mario Olivieri, et al. "Biomarkers of oxidative stress in chronic respiratory diseases." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa1108.

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Taccini, N., G. Loriga, M. Pacelli, and R. Paradiso. "Wearable monitoring system for chronic cardio-respiratory diseases." In 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2008. http://dx.doi.org/10.1109/iembs.2008.4650010.

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Oliveira Jácome, Cristina Isabel, Fábio Marques, Cátia Paixão, Patrícia Rebelo, Ana Oliveira, Joana Cruz, Célia Freitas, et al. "Digital technology access among patients with chronic respiratory diseases." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa3955.

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Evseeva, G., E. Knizhnikova, R. Telepneva, N. Kuderova, S. V. Suprun, E. Suprun, V. Kozlov, and O. Lebed'ko. "Mitochondrial Dysfunction in Chronic Diseases of the Respiratory Organs." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3453.

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Kallel, N., R. Gargouri, M. Walha, O. Badri, S. Abid, R. Khemakhem, S. Msaad, N. Moussa, A. Hentati, and S. Kammoun. "Covid19 infection in patients suffering from chronic respiratory diseases." In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.3853.

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Delmonico, Nick, and Valentin Fauveau. "A novel way to manage and control chronic respiratory diseases." In 2019 IEEE Signal Processing in Medicine and Biology Symposium (SPMB). IEEE, 2019. http://dx.doi.org/10.1109/spmb47826.2019.9037846.

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Gayle, Alicia, Eleanor Axson, Chloe Bloom, Vidya Navaratnam, and Jennifer Quint. "Changing causes of mortality for people with chronic respiratory diseases." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.oa1934.

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Avellan-Hietanen, Heidi, Matti Hänti, Timo Tervo, Vesa A. Niskanen, Paula Kauppi, Paula Maasilta, and Adel Bachour. "The paradox of chronic respiratory diseases and motor vehicle accidents." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa854.

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Звіти організацій з теми "Flavonoids, chronic respiratory diseases"

Ly, Lena, Jennifer Philip, Peter Hudson, and Natasha Smallwood. Singing for people with advance chronic respiratory diseases: a qualitative meta-synthesis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2022. http://dx.doi.org/10.37766/inplasy2022.8.0017.

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Review question / Objective: This study undertook a meta-synthesis of qualitative data with the aim of collating, synthesizing, and evaluating the current evidence regarding the experiences of singing for people with advanced chronic respiratory disease. Condition being studied: Advanced respiratory illnesses are disorders that impact the airways and other structures of the lung. People with lung cancer, chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) frequently experience progressive, frightening breathlessness, cough and fatigue, which affect their quality of life. Furthermore, people with advanced chronic respiratory disease (CRD) and their carers experience a high prevalence of loneliness and uncertainty, especially if breathlessness is felt to herald death and thus, require both psychological and practical supportive care to cope with their symptoms.

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Barros-Poblete, Marisol, Rodrigo Torres-Castro, Mauricio Henríquez, Anita Guequen, Isabel Blanco, and Carlos Flores. Dysbiosis as a prognostic factor for clinical worsening in chronic respiratory disease: A systematic review and metanalysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0089.

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Review question / Objective: Is dysbiosis a prognostic factor for clinical worsening in patients with chronic respiratory diseases?. Condition being studied: Dysbiosis, defined as changes in the quantitative and qualitative composition of the microbiota. Eligibility criteria: Over 18 years old adult patients with chronic respiratory diseases clinical diagnosis (cystic fibrosis, chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, interstitial lung disease, sarcoidosis, bronchiectasis, non-CF bronchiectasis, pulmonary hypertension) according to the International Statistical Classification of Diseases and Related Health Problems (ICD) from OMS) and international guidelines of each disease.

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Wang, Yilan, Sijing Zhao, Zherui Shen, Zhenxing Wang, and Fei Wang. Combination of Jinshuibao Capsules and Conventional Pharmaceutical Treatments for Patients with Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and a Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2021. http://dx.doi.org/10.37766/inplasy2021.10.0117.

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Review question / Objective: Jinshuibao capsules are derived from Cordyceps, and they have been widely used in the treatment of different diseases. They have also been utilized in the treatment of respiratory diseases, while their effects on patients with stable chronic obstructive pulmonary disease (COPD) have remained elusive. The present study aimed to compare the efficacy of Jinshuibao capsules plus conventional pharmaceutical treatments (CPT) versus CPT alone for patients with stable COPD. Information sources: It was attempted to conduct a systematic review and a meta-analysis based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. In addition, PubMed, EMBASE, Cochrane Library, Web of Science, China Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, VIP Information Resource Integration Service Platform (CQVIP), and China Biomedicine (SinoMed) databases were searched from inception until September 30, 2021. Google Scholar and the China Clinical Trial Registry were also searched for retrieving missing data. In emergency conditions, we contacted the corresponding authors of retrieved studies for collection of additional data.

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Rahman, Kazi, Grace Lee, Kristina Vine, Amba-Rose Atkinson, Michael Tong, and Veronica Matthews. Impacts of climate change on health and health services in northern New South Wales: an Evidence Check rapid review. The Sax Institute, December 2022. http://dx.doi.org/10.57022/xlsj7564.

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This rapid review investigated the effects of climate change on health and health services in northern NSW—a known ‘hotspot’ for natural disasters—over the next 10-20 years. It included 92 peer-reviewed articles and 9 grey literature documents, with 17% focused on Northern NSW. Climate change will cause both an increase in average temperatures and in extreme weather events and natural disasters. Impacts particularly affecting Northern NSW are expected to include increases and exacerbations of: mental illness; infectious diseases, including those transmitted by mosquitoes, water and food; heat-related illnesses; chronic diseases including respiratory and cardiac conditions; injuries; and mortality—with vulnerable groups being most affected. Demand for health services will increase, but there will also be disruptions to medication supply and service availability. A whole-of-system approach will be needed to address these issues. There are numerous gaps in the research evidence and a lack of predictive modelling and robust locally relevant data.

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