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Статті в журналах з теми "Early phase studies"
Catapano, Alberico L. "Pitavastatin – pharmacological profile from early phase studies." Atherosclerosis Supplements 11, no. 3 (December 2010): 3–7. http://dx.doi.org/10.1016/s1567-5688(10)71063-1.
Повний текст джерелаRamkumar, Anupama. "Early phase studies in India: Are we too early to explore?" Indian Journal of Pharmacology 40, no. 5 (2008): 189. http://dx.doi.org/10.4103/0253-7613.44149.
Повний текст джерелаSivasubramanian, Parijatham S., and Katherine D. Crew. "Biomarker Endpoints for Early-Phase Cancer-Prevention Studies." Current Breast Cancer Reports 5, no. 3 (June 15, 2013): 194–201. http://dx.doi.org/10.1007/s12609-013-0116-x.
Повний текст джерелаGullapalli, Rampurna P., Carolyn L. Mazzitelli, Christina M. Charriez, David J. Carpenter, Rebecca D. Crean, Bobbie Carter, and Phil Perera. "Extemporaneous preparation strategy for early phase clinical studies." International Journal of Pharmaceutics 549, no. 1-2 (October 2018): 150–60. http://dx.doi.org/10.1016/j.ijpharm.2018.07.059.
Повний текст джерелаHughes, George S. "Challenges in the Design of Phase I and Early Phase II Studies." Drug Information Journal 23, no. 4 (October 1989): 693–97. http://dx.doi.org/10.1177/009286158902300425.
Повний текст джерелаZaks, T. Z., A. Akkari, L. Briley, M. Mosteler, A. G. Stead, K. M. Koch, C. Sampson, M. Ehm, E. Harris, and A. Roses. "Role of pharmacogenetic studies in early clinical development: Phase I studies with lapatinib." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 3029. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.3029.
Повний текст джерелаMorrissey, Malcolm. "RTSM (Randomization and Trial Supply Management) for Early Phase Studies." Open Clinical Trials Journal 3, no. 1 (November 18, 2011): 26–31. http://dx.doi.org/10.2174/1876821001103010026.
Повний текст джерелаBurström, Thommie, Jussi Harri, and Timothy L. Wilson. "Nascent Entrepreneurs Managing in Networks: Equivocality, Multiplexity and Tie Formation." Journal of Enterprising Culture 26, no. 01 (March 2018): 51–83. http://dx.doi.org/10.1142/s0218495818500036.
Повний текст джерелаArato, Teruyo, Takashi Daimon, Yuji Heike, Ken Ishii, Kyogo Itho, Shinichi Kageyama, Yutaka Kawakami, et al. "2015 Guidance on cancer immunotherapy development in early‐phase clinical studies." Cancer Science 106, no. 12 (December 2015): 1761–71. http://dx.doi.org/10.1111/cas.12819.
Повний текст джерелаKacprowska, Agata, and Jacek Jassem. "Hypofractionated radiotherapy for early breast cancer: Review of phase III studies." Reports of Practical Oncology & Radiotherapy 17, no. 2 (March 2012): 66–70. http://dx.doi.org/10.1016/j.rpor.2011.10.003.
Повний текст джерелаДисертації з теми "Early phase studies"
Dahiya, Hema. "Shakespeare studies in Colonial Bengal : the early phase." Thesis, Sheffield Hallam University, 2011. http://shura.shu.ac.uk/19526/.
Повний текст джерелаFreeman, Georgina. "Publication bias and quality of reporting of Pharmacodynamic Studies utilizing invasive research procedures within early phase cancer trials." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110657.
Повний текст джерелаLes procédés de recherche effractifs, tels que la biopsie dans le cadre d'études pharmacodynamiques, n'ont souvent aucun avantage pour le patient-bénévole en ce qui concerne le diagnostic ou la prise en charge clinique. Le recours à ces procédés n'est souvent fondé que sur l'idée de la valeur des connaissances (ce en quoi ils aideront d'éventuels patients futurs) plutôt que sur l'avantage direct pour le patient.Cette thèse propose d'étudier la justification du recours à des procédés de biopsie effractive dans la recherche sur le cancer par la production de connaissances. Nous proposons comme prémisse que la recherche sur les êtres humains ne peut produire de connaissances de valeur que dans la mesure où les résultats de la recherche sont présentés de manière à permettre à la communauté scientifique élargie de les utiliser à des fins de recherches ultérieures. Nous avons étudié l'interruption de l'accumulation de connaissances de valeur selon deux critères empiriques : la publication et la qualité des renseignements. Cette thèse se concentre particulièrement sur la publication et la qualité des renseignements dans les sous-études pharmacodynamiques contenues dans les essais cliniques de premières phases dans le domaine du cancer. Ces essais visent à mesurer l'innocuité et les effets toxiques potentiels d'un nouveau médicament de recherche, ainsi que la réaction de la tumeur. Les sous-études pharmacodynamiques évaluent les effets du médicament sur ses « cibles » (un enzyme ou une voie enzymatique). Nos résultats indiquent que pour 37% des essais cliniques de premières phases qui comprennent des sous-études pharmacodynamiques utilisant la biopsie, toutes les données pharmacodynamiques ont été publiées. À la suite d'une enquête auprès d'auteurs d'études, les obstacles les plus communs sont les « considérations d'ordre stratégique quant à la publication », dans le cas d'études où on juge que les résultats n'apportent rien de nouveau ou sont sans intérêt, contradictoires ou difficiles d'interprétation, et lorsque des « différends d'ordre scientifique » empêchent la publication de résultats pharmacodynamiques (59% des répondants). La qualité des renseignements varie grandement à travers les études et on remarque que certaines données importantes pour le contrôle de la qualité ne sont qu'irrégulièrement signalées, dont les résultats de tous les tests planifiés (78% des essais), l'évaluation des résultats à l'insu (43% des essais), les dimensions des tissus prélevés (38% des essais) et la description du cheminement du patient durant la section pharmacodynamique de l'étude (62% des essais). Lorsque l'analyse pharmacodynamique est le but premier de l'essai ou que celui-ci comprend un recours obligatoire à la biopsie, l'étude tend considérablement à être de meilleure qualité. La prépondérance de résultats positifs (61% des études) suggère peut-être un biais de publication. Compte tenu des résultats de notre recherche, nous proposons que les investigateurs d'études et les membres de comités d'éthique indépendants évaluent de manière critique les objectifs en matière de recrutement des patients, de prélèvement des tissus et de validation des essais pharmacodynamiques. De plus, les comités d'éthique indépendants et les investigateurs doivent s'assurer que tout laboratoire visant le prélèvement et l'analyse de tissus par la biopsie possèdent les ressources financières, humaines et matérielles nécéssaires pour compléter une étude pharmacodynamique validée. La recommandation principale de cette thèse consiste en l'élaboration d'une ligne directrice formalisée, comparable à CONSORT ou REMARK, pour la publication d'études pharmacodynamiques. Nous recommandons également que les auteurs d'études et les éditeurs de revues envisagent de publier indépendamment les résultats pharmacodynamiques ou d'inclure des matériaux supplémentaires afin de permettre une description méthodologique plus riche de la recherche pharmacodynamique.
Smirat, Daniel. "Financial aspects facing start-ups during the go-to-market phase : Case studies of Swedish start-ups." Thesis, Luleå tekniska universitet, Institutionen för ekonomi, teknik och samhälle, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-69514.
Повний текст джерелаWainwright, Elizabeth N. "The interpretation and delivery of the Welsh Foundation Phase and its contribution to physical literacy." Thesis, University of Bedfordshire, 2014. http://hdl.handle.net/10547/576443.
Повний текст джерелаNhacolo, Arsénio Quingue [Verfasser], Werner [Akademischer Betreuer] Brannath, Werner [Gutachter] Brannath, and Martin [Gutachter] Posch. "Bias and precision in early phase adaptive oncology studies and its consequences for confirmatory trials / Arsénio Quingue Nhacolo ; Gutachter: Werner Brannath, Martin Posch ; Betreuer: Werner Brannath." Bremen : Staats- und Universitätsbibliothek Bremen, 2018. http://d-nb.info/1170321046/34.
Повний текст джерелаSohail, Aaqib [Verfasser], Frank [Akademischer Betreuer] Pessler, and Armin [Akademischer Betreuer] Braun. "Use of the human lung tissue explant model for functional biomarker studies in the early phase of infections / Aaqib Sohail ; Akademische Betreuer: Frank Pessler, Armin Braun ; Twincore, Zentrum für Experimentelle und Klinische Infektionsforschung." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2020. http://d-nb.info/1217856404/34.
Повний текст джерелаMayta, Raul E. "Socializing Housing Phased Early Response to Impromptu Migrant Encampments In Lima, Peru." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002710.
Повний текст джерелаAnanthakrishnan, Revathi Nayantara. "On the designs of early phase oncology studies." Thesis, 2017. https://hdl.handle.net/2144/27175.
Повний текст джерела2019-12-01T00:00:00Z
Nagpal, Anjali. "Exploring Determinants of Execution in Early Phase Clinical Studies with Cell Therapies in Stroke." Thesis, 2019. http://hdl.handle.net/2440/119953.
Повний текст джерелаThesis (Ph.D.) -- University of Adelaide, Adelaide Medical School, 2019
Hsieh, Tien-Hao, and 謝天晧. "The early phase of protostars and proto-brown dwarfs: Studies of Very Low Luminosity Objects (VeLLOs)." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/yngn28.
Повний текст джерела國立清華大學
天文研究所
104
My thesis project aims at understanding the natures of low mass protostars and proto-brown dwarfs at early evolutionary stage. A new category of Young Stellar Objects (YSOs), Very Low Luminosity Objects (VeLLOs), are newly discovered and defined by their low internal luminosity (Lint<0.1Lsun). The low luminosity infers that VeLLOs host a substellar mass central object at the present time and thus can be interpreted as a very young protostar or low mass protostar. This low luminosity also provides a constraint on their accretion luminosity as well as the accretion rate, suggesting VeLLOs are at a quiescent accretion phase. This thesis consists of four papers: (i) For the first paper, we develop a new identification method of YSOs to identify faint protostars in order to find more VeLLOs. Applying this method to the Spitzer archival data in five nearby molecular clouds, we identify 322 (28%) new YSO toward the lower end of the luminosity function compared with previous works. Based on this method, we further find seven VeLLOs in these molecular clouds. (ii) We study the chemical and dynamical properties of 15 selected Low Luminosity Objects (Lint<0.2Lsun) through molecular line emissions at millimeter/submillimeter wavelengths. We found that LLOs could have wide variety in their parent cores and tend to be at an very early evolutionary stage. (iii) We present a detailed investigation on the protostellar outflow driven by a unique VeLLO, IRAS 16253--2429. Our results suggest that IRAS 16253--2429 is very likely a proto-brown dwarf binary system. (iv) Using CFHT, we make an infrared outflow survey toward 20 LLOs. The outflows are detected in 12 LLOs (including 4 from Spitzer) and the outflow opening angles are widening as the core evolves as expected.
Книги з теми "Early phase studies"
Zelinger, Einat. Immunolocalisation and ultra-structural studies of the early interactions between Stagonospora nodorum and wheat. [Oxford]: Oxford Brookes University, 2002.
Знайти повний текст джерелаSwamidass, Paul M. The early phases of technological innovation for engineering and business students: With 16 case studies. Auburn, AL: TIR/Technological Innovation Resources, 2012.
Знайти повний текст джерелаFlüeler, Remo Peter. Experimentelle Untersuchungen über Keimung und Etablierung von alpinen Leguminosen =: Experimental studies on the germinating behaviour and early developmental phases of alpine Leguminosae. Zürich: Geobotanischen Institutes ETH, Stiftung Rübel, 1992.
Знайти повний текст джерелаNairn, J. A. Greek through reading. Bristol: Bristol Classical Press, 1993.
Знайти повний текст джерелаThe rhetoric of gender terms: 'man', 'woman', and the portrayal of character in Latin prose. Leiden: Brill, 1992.
Знайти повний текст джерелаBernards, Monique. Changing traditions: Al-Mubarrad's refutation of Sībawayh and the subsequent reception of the Kitāb. Leiden: E.J. Brill, 1996.
Знайти повний текст джерела(Editor), Patricia P. Olmsted, and Jeanne Montie (Editor), eds. Early Childhood Settings in 15 Countries: What Are Their Structural Characteristics? (The Iea Preprimary Project, Phase 2). High/Scope Pr, 2001.
Знайти повний текст джерелаTranslational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development: A Focus on Early Phase Clinical Studies. Springer, 2014.
Знайти повний текст джерелаKrentz, Andrew J., Lutz Heinemann, and Marcus Hompesch. Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development: A Focus on Early Phase Clinical Studies. Springer London, Limited, 2014.
Знайти повний текст джерелаKrentz, Andrew J., Steven Smith, Lutz Heinemann, and Marcus Hompesch. Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development: A Focus on Early Phase Clinical Studies. Springer, 2016.
Знайти повний текст джерелаЧастини книг з теми "Early phase studies"
Colin, Laurence, and Brian Smith. "Safety in Early Phase Studies." In Statistical Methods in Biomarker and Early Clinical Development, 247–74. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-31503-0_12.
Повний текст джерелаHalloran, M. Elizabeth, Ira M. Longini, and Claudio J. Struchiner. "Immunology and Early Phase Trials." In Design and Analysis of Vaccine Studies, 47–62. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-0-387-68636-3_3.
Повний текст джерелаMcEwen, J., and Ian H. Stevenson. "Radiolabelled Metabolism Studies in Man." In Early Phase Drug Evaluation in Man, 243–50. London: Macmillan Education UK, 1990. http://dx.doi.org/10.1007/978-1-349-10705-6_20.
Повний текст джерелаBroom, Colin. "Design of First-administration Studies in Healthy Man." In Early Phase Drug Evaluation in Man, 206–13. London: Macmillan Education UK, 1990. http://dx.doi.org/10.1007/978-1-349-10705-6_16.
Повний текст джерелаCamidge, D. Ross, Robert C. Doebele, and Antonio Jimeno. "Pharmacodynamic Studies in Early Phase Drug Development." In Principles of Anticancer Drug Development, 215–56. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-7358-0_9.
Повний текст джерелаSathyanarayanan, Vishwanath, and Swaminathan P. Iyer. "The Paradigm of Early Phase Studies in Hematological Malignancies." In Phase I Oncology Drug Development, 297–311. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-47682-3_17.
Повний текст джерелаLindenberg, Svend, and Poul Hyttel. "In vitro studies of the peri-implantation phase of human embryos." In Ultrastructure of Human Gametogenesis and Early Embryogenesis, 201–11. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-1749-4_7.
Повний текст джерелаZheng, Yanbing, James Reynolds, Man Tang, Mark Johnson, and Hesham Fahmy. "A Bayesian Application in Process Monitoring – Establishing Limits for Dosage Units in Early Phase Process Control." In Case Studies in Bayesian Methods for Biopharmaceutical CMC, 299–320. Boca Raton: Chapman and Hall/CRC, 2022. http://dx.doi.org/10.1201/9781003255093-15.
Повний текст джерелаPithawalla, Y. B., and M. Samy El-Shall. "Gas Phase and Cluster Studies of the Early Stages of Cationic Polymerization and the Reactions with Metal Cations." In Solvent-Free Polymerizations and Processes, 232–45. Washington, DC: American Chemical Society, 1999. http://dx.doi.org/10.1021/bk-1998-0713.ch015.
Повний текст джерелаShortino, Denise, Ann Walker, and Andrew Miskell. "Use of Graphics for Studies with Small Sample Sizes: A Simulated Case Study of an Early-Phase Asset for Treatment of Type 2 Diabetes Mellitus." In A Picture is Worth a Thousand Tables, 87–97. Boston, MA: Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-5329-1_5.
Повний текст джерелаТези доповідей конференцій з теми "Early phase studies"
Rusli, Andre, and Osamu Shigo. "An integrated tool to support early-phase requirements analysis." In 2017 4th International Conference on New Media Studies (CONMEDIA). IEEE, 2017. http://dx.doi.org/10.1109/conmedia.2017.8266026.
Повний текст джерелаRoffel, AF, PJ Vrijlandt, and AA Van Vliet. "Patient Recruitment in Early Phase Investigational Drug Studies in Asthma and COPD." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1437.
Повний текст джерелаVan Bossuyt, Douglas, Chris Hoyle, Irem Y. Tumer, Richard Malak, Toni Doolen, and Andy Dong. "Toward an Early-Phase Conceptual System Design Risk-Informed Decision Making Framework." In ASME 2012 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/imece2012-89639.
Повний текст джерелаCoombs, Deshawn M., Nathan D. Peters, and Ben Akih-Kumgeh. "Experimental and Numerical Investigation of Early Phase of Laser Ignition Under Stoichiometric and Lean Conditions." In ASME Turbo Expo 2018: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/gt2018-77238.
Повний текст джерелаAletaha, D., A. Kivitz, G. Valenzuela, J. Tesser, S. Hays, H. Li, CA Connell, E. Bananis, A. Soonasra, and JS Smolen. "THU0186 Magnitude and duration of early response with tofacitinib: post-hoc analysis of two phase 3, placebo-controlled studies." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.1556.
Повний текст джерелаFoss, Ryan J., Mengtang Li, Eric J. Barth, Kim A. Stelson, and James D. Van de Ven. "Experimental Studies of a Novel Alternating Flow (AF) Hydraulic Pump." In ASME/BATH 2017 Symposium on Fluid Power and Motion Control. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/fpmc2017-4315.
Повний текст джерелаMayer, Ingrid, Azeez Farooki, Hope S. Rugo, Hiroji Iwata, Eva Ciruelos, Mario Campone, Sibylle Loibl, et al. "Abstract PS10-35: Early intervention for and management of alpelisib (ALP)-induced hyperglycemia: Case studies from the phase III SOLAR-1 trial." In Abstracts: 2020 San Antonio Breast Cancer Virtual Symposium; December 8-11, 2020; San Antonio, Texas. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.sabcs20-ps10-35.
Повний текст джерелаHånde, Bjørn M. "Performance Prediction of Centrifugal Compressors During the Conceptual Engineering Phase." In ASME 1994 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1994. http://dx.doi.org/10.1115/94-gt-192.
Повний текст джерелаYu, Leyuan, and Dong Liu. "Flow Boiling Heat Transfer and Two-Phase Flow Instability of Nanofluids in a Minichannel." In ASME 2013 Heat Transfer Summer Conference collocated with the ASME 2013 7th International Conference on Energy Sustainability and the ASME 2013 11th International Conference on Fuel Cell Science, Engineering and Technology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/ht2013-17154.
Повний текст джерелаYener, Yaman, and Salih Saran. "Recent Developments in Single-Phase Transient Forced Convection in Channels: A State-of-Art-Review." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-42665.
Повний текст джерелаЗвіти організацій з теми "Early phase studies"
Scott, B. R., F. F. Hahn, G. J. Newton, M. B. Snipes, E. G. Damon, J. L. Mauderly, B. B. Boecker, and D. H. Gray. Experimental studies of the early effects of inhaled beta-emitting radionuclides for nuclear accident risk assessment: Phase 2 report. Office of Scientific and Technical Information (OSTI), November 1987. http://dx.doi.org/10.2172/5555806.
Повний текст джерелаMarking, Gregory Allen. Studies of high temperature ternary phases in mixed-metal-rich early transition metal sulfide and phosphide systems. Office of Scientific and Technical Information (OSTI), January 1994. http://dx.doi.org/10.2172/10119308.
Повний текст джерелаThurston, Alexander. In Brief: Foreword for the Lake Chad Basin Research Initiative Compendium. RESOLVE Network, January 2021. http://dx.doi.org/10.37805/lcb2021.1.
Повний текст джерелаLevy, Avraham A., and Virginia Walbot. Regulation of Transposable Element Activities during Plant Development. United States Department of Agriculture, August 1992. http://dx.doi.org/10.32747/1992.7568091.bard.
Повний текст джерелаHall, Mark, and Neil Price. Medieval Scotland: A Future for its Past. Society of Antiquaries of Scotland, September 2012. http://dx.doi.org/10.9750/scarf.09.2012.165.
Повний текст джерелаRankin, Nicole, Deborah McGregor, Candice Donnelly, Bethany Van Dort, Richard De Abreu Lourenco, Anne Cust, and Emily Stone. Lung cancer screening using low-dose computed tomography for high risk populations: Investigating effectiveness and screening program implementation considerations: An Evidence Check rapid review brokered by the Sax Institute (www.saxinstitute.org.au) for the Cancer Institute NSW. The Sax Institute, October 2019. http://dx.doi.org/10.57022/clzt5093.
Повний текст джерелаSoloviev, Vladimir, Oleksandr Serdiuk, Serhiy Semerikov, and Arnold Kiv. Recurrence plot-based analysis of financial-economic crashes. [б. в.], October 2020. http://dx.doi.org/10.31812/123456789/4121.
Повний текст джерелаHochman, Ayala, Thomas Nash III, and Pamela Padgett. Physiological and Biochemical Characterization of the Effects of Oxidant Air Pollutants, Ozone and Gas-phase Nitric Acid, on Plants and Lichens for their Use as Early Warning Biomonitors of these Air Pollutants. United States Department of Agriculture, January 2011. http://dx.doi.org/10.32747/2011.7697115.bard.
Повний текст джерелаFields, Michael J., Mordechai Shemesh, and Anna-Riitta Fuchs. Significance of Oxytocin and Oxytocin Receptors in Bovine Pregnancy. United States Department of Agriculture, August 1994. http://dx.doi.org/10.32747/1994.7568790.bard.
Повний текст джерелаKingston, A. W., O. H. Ardakani, and R A Stern. Tracing the subsurface sulfur cycle using isotopic and elemental fingerprinting: from the micro to the macro scale. Natural Resources Canada/CMSS/Information Management, 2022. http://dx.doi.org/10.4095/329789.
Повний текст джерела