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Статті в журналах з теми "DRUG DESIGNING"
Sehgal, Vijay Kumar, Supratik Das, and Anand Vardhan. "Computer Aided Drug Designing." International Journal of Medical and Dental Sciences 6, no. 1 (January 1, 2017): 1433. http://dx.doi.org/10.18311/ijmds/2017/18804.
Повний текст джерелаSana, F., J. Ayesha, F. Talath, and H. Sharequa. "Computational Drug Designing of Anticancer Drugs." International Journal for Pharmaceutical Research Scholars 7, no. 2 (2018): 58–70. http://dx.doi.org/10.31638/ijprs.v7.i2.00032.
Повний текст джерелаSehgal, Vijay Kumar, Supratik Das, and Anand Vardhan. "Computer Aided Drug Designing." International Journal of Medical and Dental Sciences 6, no. 1 (January 1, 2017): 1433. http://dx.doi.org/10.19056/ijmdsjssmes/2017/v6i1/125571.
Повний текст джерелаLambert, Bruce L., Swu-Jane Lin, and HiangKiat Tan. "Designing Safe Drug Names." Drug Safety 28, no. 6 (2005): 495–512. http://dx.doi.org/10.2165/00002018-200528060-00003.
Повний текст джерелаGibson, T. P. "Designing Dialysis Drug Studies." International Journal of Artificial Organs 8, no. 2 (March 1985): 69–70. http://dx.doi.org/10.1177/039139888500800202.
Повний текст джерелаKaur, Navneet, Mymoona Akhter, and Chhavi Singla. "Drug designing: Lifeline for the drug discovery and development process." Research Journal of Chemistry and Environment 26, no. 8 (July 25, 2022): 173–79. http://dx.doi.org/10.25303/2608rjce1730179.
Повний текст джерелаBODOR, NICHOLAS. "Designing Safer Ophthalmic Drugs by Soft Drug Approaches." Journal of Ocular Pharmacology and Therapeutics 10, no. 1 (January 1994): 3–15. http://dx.doi.org/10.1089/jop.1994.10.3.
Повний текст джерелаR, Noor. "A Short Note on the General Aspects of Drug Designing." Open Access Journal of Microbiology & Biotechnology 6, no. 1 (2021): 1–4. http://dx.doi.org/10.23880/oajmb-16000184.
Повний текст джерелаMullasseril, Abhilash. "Drug Designing An Ayurvedic Perspective." IOSR Journal of Pharmacy (IOSRPHR) 3, no. 4 (May 2013): 29–33. http://dx.doi.org/10.9790/3013-034202933.
Повний текст джерелаReddy, Nageswara Rao. "Medicinal Chemistry and Drug Designing." Journal of Medicinal Chemistry and Toxicology 1, no. 1 (July 21, 2016): 15–16. http://dx.doi.org/10.15436/2575-808x.16.1002.
Повний текст джерелаДисертації з теми "DRUG DESIGNING"
Lundberg, Pontus. "Designing Polymers for Biological Interfaces - From Antifouling to Drug Delivery." Doctoral thesis, KTH, Ytbehandlingsteknik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-26413.
Повний текст джерелаIckespecifika interaktioner vid gränsytan, mellan ett syntetiskt material och en vattenbaserad biologisk miljö, kan leda till irreversibel adsorption av proteiner. Detta kan i sin tur leda till oönskade följdeffekter, såsom beväxning på båtskrov eller trigga en immunologisk reaktion. För att motverka dessa effekter har forskare utvecklat så kallade smygmaterial. Denna avhandling behandlar design av nätverk, nanopartiklar och ytor innehållande poly(etylenglykol) (PEG), som är känt för sina smygegenskaper och för att vara icke-toxiskt. Initialt behandlar avhandlingen PEG-baserade nätverk, hydrogeler, syntetiserade med fotoinitierad tiol-enekemi, för användning som beväxningsavvisande beläggningar för marina applikationer. Genom att variera olika parametrar, såsom längden på PEG-kedjan, härdningskemin, tvärbindaren samt den hydrolytiska stabiliteten, byggdes ett bibliotek av hydrogelbeläggningar upp. Hydrogelbeläggningarna karaktäriserades sedan med avseende på härdningseffektivitet, termiska och mekaniska egenskaper, samt hydrolytisk stabilitet. Vidare studerades beläggningarnas avvisande förmåga mot proteiner, bakterier samt kiselalger. Slutligen studerades ytbeläggningarna i ett fyra månader långt fälttest. Av testerna framgick att längre PEG-kedjor gav beläggningar med bättre avvisande förmåga. Dessutom framgick att valet av tvärbindare, härdningskemi samt hydrolytisk stabilitet var av betydelse för beläggningarnas effektivitet. Denna avhandling behandlar vidare design av amfifila linjära dendritiska hybridmaterial, med PEG som den hydrofila delen. Genom att använda icke-toxiska 2,2-bis(metylol)propionsyrabaserade dendroner, med en klickfunktionalitet i kärnan (alkyne eller allyl) och perifera hydroxylgrupper, som makroinitiatorer för ringöppningspolymerisation av ε-kaprolakton byggdes ett bibliotek av material upp. För att göra materialen amfifila, kopplades klickfunktionella PEG-kedjor (azid eller tiol) till kärnan med koppar(I)-katalyserad azid-alkyn cykloadditionskemi alternativt tiol-enekemi. Storleken på dendronerna varierades från generation 0-4, dessutom varierades längden på både poly(ε-kaprolakton)- och PEG-kedjorna. Materialen designades så att inverkan av dendrongenerationen kunde studeras. Slutligen användes dessa hybridmaterial för att framställa miceller samt isoporösa filmer. Micellernas kritiska micellbildningskoncentration, storlek samt förmåga att laddas med läkemedel visade sig vara mycket beroende av dendrongenerationen. Dendrongenerationen visade sig vidare även ha stor inverkan i hybridmaterialens förmåga att självorganisera sig till en isoporös struktur och material av tredje generationen gav de mest välordnade filmerna.
QC 20101125
Engstrand, Johanna. "Designing star-like block-copolymers as compartmentalized nanostructures for drug delivery applications." Thesis, Uppsala University, Department of Materials Chemistry, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-119971.
Повний текст джерелаThis thesis describes syntheses and characterization of star-like amphiphilic block copolymers consisting of poly(ethylene glycol) (PEG) as the hydrophilic block,polycarbonate as the hydrophobic block and an amine-containing dendrimer as the core molecule. The macromolecules were synthesized by either a convergent or adivergent approach that includes tandem click reactions and ring opening polymerizations (ROP) of methyl trimethyl carbonates (MTC) with differentfunctionalities. The ROP of MTC monomers was performed using organocatalysts that allow mild reaction condition and reasonable molecular weight distribution(PDI~1.3). These synthetic approaches provide the resultant polymers with three different conformations, which are; mikto-arm type, comb-block with short PEGbrushes, and linear block with long PEG chain. The star-like polymers that were synthesized were all water soluble and most of them formed nano aggregates inwater. Different morphologies were observed in AFM study depending on the polymer conformation. Interestingly, some of them had indications pointing towards alower critical solution temperature.
Guillet-Nicolas, Rémy. "Designing ordered mesoporous materials for MRI cell tracking and oral drug delivery applications." Thesis, Université Laval, 2014. http://www.theses.ulaval.ca/2014/30515/30515.pdf.
Повний текст джерелаAmong recent discoveries in material science, ordered mesoporous silica (OMS) have been in the limelight and attracted considerable attention because of their prospects of application, especially in the biomedical field and separation technologies. Such growing interest is explained by their unique physico-chemical properties. Indeed, OMS usually exhibit high specific surface areas, high pore volumes, adjustable pore sizes, ease of surface functionalization and customizable particle size and shape. The main objective of this Ph.D. thesis is to use these properties in order to design and characterize novel systems with potential applications in magnetic resonance imaging (MRI) and/or oral drug delivery. The first and second parts of this project (chapters 4 and 5) deal with SBA-15 and KIT-6 materials and the effects of the different synthesis parameters on the porosity features of the structures, obtained after calcination. The results showed that it is of prime interest to thoroughly and accurately characterize the porosity of these silicas in order to correctly assess their porous topologies. Such knowledge could be of substantial importance for high-tech applications of OMS. The third and fourth part of this thesis (chapters 6 and 7) are aimed to design, characterize and evaluate the potential of novel positive contrast agents (CA) for MRI based on MCM-41 and MCM-48 nanoparticles (Nps) functionalized with paramagnetic ions such as gadolinium (Gd) or manganese (Mn). The results reported in these studies demonstrate the superiority of 3-D pore networks as a host for the insertion of paramagnetic atoms used to enhance the signal in MRI. Also Gd and Mn loaded MCM-48 Nps provide a significant increase in 1H proton longitudinal relaxivity while maintaining low r2/r1 ratio (1.5 – 2) in water. Furthermore, various modern techniques and in vitro tests were used to clearly delineate the true potential and limitations of these inorganic contrast agents for cellular and in vivo tracking studies. The last part of this work (chapter 8) is focused on the binding of a succinylated protein, the β-lactoglobulin, onto functionalized MCM-48 Nps for the development of a new oral drug delivery platform. This nutraceutical nano-conjugate system reveals promising features such as high biocompatibility, efficient pH-responsive properties for both hydrophilic and hydrophobic drugs/dyes and excellent colloidal stability. The use of this low-cost protein could represent an alternative over classical biopolymers.
Gaskell, Elsie. "Designing a mucinolytic drug delivery system for the potential treatment of cystic fibrosis." Thesis, Liverpool John Moores University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436551.
Повний текст джерелаDepan, D. "Novel designing of chitosan based nanocomposites for tissue engineering and drug delivery applications." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2008. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2681.
Повний текст джерелаStolzoff, Michelle L. "Designing the surface properties of expansile nanoparticles for targeted cancer therapy." Thesis, Boston University, 2013. https://hdl.handle.net/2144/21256.
Повний текст джерелаNanoparticle-based drug delivery has been explored to circumvent the often-toxic chemotherapy treatments used today by providing a more efficient and specific delivery to diseased tissues. Recently we have developed polymeric pH-responsive expansile nanoparticles (eNPs) for intracellular delivery of paclitaxel (Pax) as an improvement upon the traditional methods of delivery of Pax with using Cremophor/ethanol. As eNPs are internalized by the cell, the hydrophobic protecting groups found on side chains along the polymer backbone are hydrolyzed, leaving behind hydrophilic moieties that cause the eNPs to slowly swell with water. In this manner, the encapsulation and controlled release of a hydrophobic drug can be achieved. By altering the surface characteristics of the eNPs, one can change the behavior of the delivery vehicle as well as the biological response. To explore this approach, two surfactant strategies were employed. Specifically, the original sodium dodecyl sulfate (SDS) surfactant has been substituted with PEGylated surfactants (either lipids or poloxamer) to improve circulation and in vivo stability. In addition, these surfactants were functionalized to target the folate receptor (FR), which is overexpressed in several cancers, in order to increase cancer cell-specific localization and uptake. The resulting eNPs retained their swelling characteristics while demonstrating improved cellular uptake in folate receptor-expressing KB and MDA-MB-231 carcinoma cells with no change in uptake in A549 cells, which do not express the folate receptor.
2031-01-01
Jalili, Vahid. "Application of CFD in designing a drug delivery mixing chamber : an experimental and computational study." Thesis, University of Greenwich, 2004. http://gala.gre.ac.uk/6196/.
Повний текст джерелаHabib, Eric. "Designing an inhibitor for AAC(6')- Ii by fragment-based drug design using SAR by NMR." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119433.
Повний текст джерелаLes aminoglycosides sont une classe importante d'antibiotiques à large spectre, efficaces contre les bactéries Gram-positives et Gram-négatives. La résistance des bactéries envers les antibiotiques demeure un problème depuis leur découverte. Un des mécanismes principaux de résistance aux aminoglycosides est leur modification par l'enzyme aminoglycoside N-6'-aminotransférase (AAC(6')). Inhiber la résistance antibiotique est une stratégie qui a fait ses preuves pour contrer ce problème. Le groupe Auclair a précédemment développé une série de bisubstrats aminoglycoside-coenzyme A qui sont de puissants inhibiteurs in vitro mais sont inefficaces dans des essais cellulaires. Pour combattre la résistance aux aminoglycosides, cette thèse vise le développement d'une nouvelle classe d'inhibiteurs d'AAC(6') en utilisant une approche par fragments avec des essais à base de RMN pour le criblage initial. Cette approche a l'avantage de potentiellement trouver de nouveaux patrons structurels, fondamentalement différents de ceux qui ont été précédemment découverts. Suivant l'introduction dans le chapitre 1. Le chapitre 2 décrit le criblage par RMN d'une librairie de composés avec l'enzyme AAC(6')-Ii. Les molécules actives ont ensuite été caractérisées en complexe avec la protéine par RMN dont la HSQC. Le chapitre 3 décrit la synthèse de composés modifiés basés sur les résultats du criblage initial aussi bien que la caractérisation de leur complexation avec l'enzyme par DSF et par mesures d'essais cinétiques. Seul un ligand a été trouvé un meilleur ligand que les ligands initiaux. Un des composés hybrides montrait une légère amélioration dans son affinité pour AAC(6')-Ii, mais son activité est trop faible pour que cet inhibiteur mérite de plus amples études.
Stumper, Anne [Verfasser]. "Designing potent PDT drug candidates - development of crucial linking strategies for biomolecule-metal-complex-conjugates / Anne Stumper." Ulm : Universität Ulm, 2018. http://d-nb.info/1150301856/34.
Повний текст джерелаKumari, S. "Designing of chitosan and metal/metal oxide nanoparticle based nanocomposites for tissue engineering and drug delivery applications." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2013. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2261.
Повний текст джерелаКниги з теми "DRUG DESIGNING"
Kinam, Park, and Mrsny Randy J. 1955-, eds. Controlled drug delivery: Designing technologies for the future. Washington, D.C: American Chemical Society, 2000.
Знайти повний текст джерелаEvans, David G. Designing an effective drug-free workplace compliance program. Deerfield, IL: Clark Boardman Callaghan, 1993.
Знайти повний текст джерелаMayforth, Ruth D. Designing antibodies. San Diego: Academic Press, Inc., 1993.
Знайти повний текст джерелаR, Antos Joseph, Spoor Christian, and United States. Congressional Budget Office., eds. Issues in designing a prescription drug benefit for Medicare. [Washington, D.C.]: Congress of the United States, Congressional Budget Office, 2002.
Знайти повний текст джерела1942-, Ellickson Phyllis L., ed. Designing and implementing Project ALERT: A smoking and drug prevention experiment. Santa Monica, CA: RAND, 1988.
Знайти повний текст джерелаLoomis, Lloyd. Drug testing: A workplace guide to designing practical policies and winning arbitrations. Washington, D.C: Bureau of National Affairs, 1990.
Знайти повний текст джерелаCenter, Joslin Diabetes, ed. Joslin's insulin deskbook: Designing and initiating insulin treatment programs. Boston, MA: Joslin Diabetes Center, c2008., 2008.
Знайти повний текст джерелаRahrer, J. Stuart. Preparing for tomorrow-- today: Designing a personalized plan to prevent your child's alcohol-drug abuse. Fort Wayne, IN: Pharos Consulting & Publications, 1997.
Знайти повний текст джерелаBarbara, Davis. Peer support: Designing interpersonal skills training plan. [Edmonton]: Alberta Alcohol and Drug Abuse Commission, 1989.
Знайти повний текст джерелаMarch, Darren. Designing new antiviral drugs for AIDS: HIV-1 protease and its inhibitors. Austin: R.G. Landes, 1996.
Знайти повний текст джерелаЧастини книг з теми "DRUG DESIGNING"
Klebe, Gerhard. "Designing Prodrugs." In Drug Design, 173–88. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-17907-5_9.
Повний текст джерелаGupta, Varsha, Manjistha Sengupta, Jaya Prakash, and Baishnab Charan Tripathy. "Rational Drug Designing." In Basic and Applied Aspects of Biotechnology, 263–78. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-0875-7_12.
Повний текст джерелаRehman, Nahid, and Anjana Pandey. "Drug Designing and Drug Delivery." In Engineered Nanoparticles as Drug Delivery Systems, 11–24. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003252122-3.
Повний текст джерелаTurner, J. Rick. "Designing Clinical Trials." In New Drug Development, 47–67. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6418-2_5.
Повний текст джерелаGore, Mohini, and Neetin S. Desai. "Computer-Aided Drug Designing." In Methods in Molecular Biology, 313–21. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0847-9_18.
Повний текст джерелаRajkishan, Thakor, Ailani Rachana, Surani Shruti, Patel Bhumi, and Dhaval Patel. "Computer-Aided Drug Designing." In Advances in Bioinformatics, 151–82. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-6191-1_9.
Повний текст джерелаCummins, David Jesse. "Pharmaceutical Drug Discovery: Designing the Blockbuster Drug." In Screening, 69–114. New York, NY: Springer New York, 2006. http://dx.doi.org/10.1007/0-387-28014-6_4.
Повний текст джерелаChuang-Stein, Christy, and Simon Kirby. "Designing Phase 4 Trials." In Quantitative Decisions in Drug Development, 139–51. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-46076-5_10.
Повний текст джерелаChuang-Stein, Christy, and Simon Kirby. "Designing Phase 4 Trials." In Quantitative Decisions in Drug Development, 163–76. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-79731-7_10.
Повний текст джерелаGupta, Munishwar N., and Joyeeta Mukherjee. "Designing Nanocarriers for Drug Delivery." In Nanomedicine for Drug Delivery and Therapeutics, 411–36. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118636299.ch14.
Повний текст джерелаТези доповідей конференцій з теми "DRUG DESIGNING"
Wang, Jing-Fang, Lin Li, Dong-Qing Wei, and Kuo-Chen Chou. "Discovery of Anti-Hiv Drugs Using Computer Aided Drug Designing Tools." In 2007 1st International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2007. http://dx.doi.org/10.1109/icbbe.2007.87.
Повний текст джерелаGhosh, Anupam, Mainak Talukdar, and Uttam Kumar Roy. "Stable Drug Designing by Minimizing Drug Protein Interaction Energy Using PSO." In Fifth International Conference on Advances in Computing and Information Technology. Academy & Industry Research Collaboration Center (AIRCC), 2015. http://dx.doi.org/10.5121/csit.2015.51306.
Повний текст джерелаKumar, Dhananjay, Anshul Sarvate, Sakshi Singh, and Puja Priya. "Comparative modelling and in-silico drug designing." In 2013 IEEE Conference on Information & Communication Technologies (ICT). IEEE, 2013. http://dx.doi.org/10.1109/cict.2013.6558165.
Повний текст джерелаVaidya, Pankaj, Shweta Chauhan, and Varun Jaiswal. "Prediction of Multi Class Drugs: A Perspective for Designing Drug with Many Uses." In 2022 2nd International Conference on Artificial Intelligence and Signal Processing (AISP). IEEE, 2022. http://dx.doi.org/10.1109/aisp53593.2022.9760640.
Повний текст джерелаBobde, Shravani, Fahad Alsaab, Guangshun Wang, and Monique L. van Hoek. "Designing novel antimicrobial peptides against multi-drug resistant bacteria." In BCB '21: 12th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics. New York, NY, USA: ACM, 2021. http://dx.doi.org/10.1145/3459930.3469507.
Повний текст джерела"Drug Designing, Synthesis and Biological Evaluation of Novel Ciprofloxacin Analogues." In 3rd INTERNATIONAL CONFERENCE ON BIOLOGICAL RESEARCH AND APPLIED SCIENCE. Jinnah University for Women, Karachi,Pakistan, 2023. http://dx.doi.org/10.37962/ibras/2023/38-40.
Повний текст джерелаKaur, Tejinder, Divya Dhawal Bhandari, and Rajiv Sharma. "Cloud Computing: A relevant Solution for Drug Designing using different Software’s." In 2021 Sixth International Conference on Image Information Processing (ICIIP). IEEE, 2021. http://dx.doi.org/10.1109/iciip53038.2021.9702618.
Повний текст джерелаKalpna, Ramesh Kumar Srivastava, and Ravindra Nath. "Structure based drug designing against Inosine Monophosphate Dehydrogenase Receptor of Cryptosporidium parvum." In 2018 International Conference on Bioinformatics and Systems Biology (BSB). IEEE, 2018. http://dx.doi.org/10.1109/bsb.2018.8770643.
Повний текст джерелаHassan, Alharith A. A., Katalin Kristó, and Tamás Sovány. "Designing of buccal mucoadhesive films as a drug delivery platform for biopharmaceuticals." In IV. Symposium of Young Researchers on Pharmaceutical Technology,Biotechnology and Regulatory Science. Szeged: Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 2022. http://dx.doi.org/10.14232/syrptbrs.2022.13.
Повний текст джерелаKoutalonis, M., E. J. Cook, J. A. Griffiths, J. A. Horrocks, C. Gent, S. Pani, L. George, S. Hardwick, and R. Speller. "Designing an in-field system for illicit drug detection using X-ray diffraction." In 2009 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC 2009). IEEE, 2009. http://dx.doi.org/10.1109/nssmic.2009.5402460.
Повний текст джерелаЗвіти організацій з теми "DRUG DESIGNING"
Ye, Yanping. Designing New Drugs to Treat Cardiac Arrhythmia. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.638.
Повний текст джерела