Готові списки джерел за темами / Drug Delivery Applications

Добірка наукової літератури з теми "Drug Delivery Applications"

Автор: Grafiati
Опубліковано: 10 грудня 2022
Оновлено: 29 січня 2023

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Статті в журналах з теми "Drug Delivery Applications"

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Mohanty, Swati. "Chitosan Dendrimer for Drug Delivery Applications." Journal of Advance Nanobiotechnology 2, no. 5 (October 30, 2018): 16–19. http://dx.doi.org/10.28921/jan.2018.02.28.

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T. Varkey, Jaya. "Peptides-Incorporated Nanoparticles for Imaging and Drug Delivery Applications." Journal of Pharmaceutical and Medicinal Chemistry 2, no. 2 (2016): 145–48. http://dx.doi.org/10.21088/jpmc.2395.6615.2216.4.

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Priya, V. Sri Vajra, Hare Krishna Roy, N. jyothi, and N. Lakshmi Prasanthi. "Polymers in Drug Delivery Technology, Types of Polymers and Applications." Scholars Academic Journal of Pharmacy 5, no. 7 (July 2016): 305–8. http://dx.doi.org/10.21276/sajp.2016.5.7.7.

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Ng, Jaryl Chen Koon, Daniel Wee Yee Toong, Valerie Ow, Su Yin Chaw, Hanwei Toh, Philip En Hou Wong, Subbu Venkatraman, et al. "Progress in drug-delivery systems in cardiovascular applications: stents, balloons and nanoencapsulation." Nanomedicine 17, no. 5 (February 2022): 325–47. http://dx.doi.org/10.2217/nnm-2021-0288.

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Drug-delivery systems in cardiovascular applications regularly include the use of drug-eluting stents and drug-coated balloons to ensure sufficient drug transfer and efficacy in the treatment of cardiovascular diseases. In addition to the delivery of antiproliferative drugs, the use of growth factors, genetic materials, hormones and signaling molecules has led to the development of different nanoencapsulation techniques for targeted drug delivery. The review will cover drug delivery and coating mechanisms in current drug-eluting stents and drug-coated balloons, novel innovations in drug-eluting stent technologies and drug encapsulation in nanocarriers for delivery in vascular diseases. Newer technologies and advances in nanoencapsulation techniques, such as the use of liposomes, nanogels and layer-by-layer coating to deliver therapeutics in the cardiovascular space, will be highlighted.
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5

Li, Wei, Jing Lin, Tianfu Wang, and Peng Huang. "Photo-triggered Drug Delivery Systems for Neuron-related Applications." Current Medicinal Chemistry 26, no. 8 (May 16, 2019): 1406–22. http://dx.doi.org/10.2174/0929867325666180622121801.

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The development of materials, chemistry and genetics has created a great number of systems for delivering antibiotics, neuropeptides or other drugs to neurons in neuroscience research, and has also provided important and powerful tools in neuron-related applications. Although these drug delivery systems can facilitate the advancement of neuroscience studies, they still have limited applications due to various drawbacks, such as difficulty in controlling delivery molecules or drugs to the target region, and trouble of releasing them in predictable manners. The combination of optics and drug delivery systems has great potentials to address these issues and deliver molecules or drugs to the nervous system with extraordinary spatiotemporal selectivity triggered by light. In this review, we will introduce the development of photo-triggered drug delivery systems in neuroscience research and their neuron-related applications including regulating neural activities, treating neural diseases and inducing nerve regenerations.
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Ramanujam, Ranjith, Balraj Sundaram, Ganesh Janarthanan, Elamparithi Devendran, Moorthy Venkadasalam, and M. C. John Milton. "Biodegradable Polycaprolactone Nanoparticles Based Drug Delivery Systems: A Short Review." Biosciences, Biotechnology Research Asia 15, no. 3 (September 25, 2018): 679–85. http://dx.doi.org/10.13005/bbra/2676.

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Nanoparticles based drug delivery systems showing greater potential in various biomedical applications to deliver the drugs/bioactive molecules in controlled manner to the targeted site. Polycaprolactone, biodegradable polyester, owing its tailorable properties, various forms of polycaprolactone are used as drug carrier for a range of biomedical applications. Nanoprecipitation is a simple method to prepare the polycaprolactone nanoparticles to improve the bioavailability and therapeutic potential of various drugs/bioactive molecules. This short review focused on the preparation of polycaprolactone nanoparticles using nanoprecipitation method, nanoparticles-drug formulations and its use in various drug delivery applications.
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Pentlavalli, Sreekanth, Sophie Coulter, and Garry Laverty. "Peptide Nanomaterials for Drug Delivery Applications." Current Protein & Peptide Science 21, no. 4 (April 29, 2020): 401–12. http://dx.doi.org/10.2174/1389203721666200101091834.

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Self-assembled peptides have been shown to form well-defined nanostructures which display outstanding characteristics for many biomedical applications and especially in controlled drug delivery. Such biomaterials are becoming increasingly popular due to routine, standardized methods of synthesis, high biocompatibility, biodegradability and ease of upscale. Moreover, one can modify the structure at the molecular level to form various nanostructures with a wide range of applications in the field of medicine. Through environmental modifications such as changes in pH and ionic strength and the introduction of enzymes or light, it is possible to trigger self-assembly and design a host of different self-assembled nanostructures. The resulting nanostructures include nanotubes, nanofibers, hydrogels and nanovesicles which all display a diverse range of physico-chemical and mechanical properties. Depending on their design, peptide self-assembling nanostructures can be manufactured with improved biocompatibility and in vivo stability and the ability to encapsulate drugs with the capacity for sustained drug delivery. These molecules can act as carriers for drug molecules to ferry cargo intracellularly and respond to stimuli changes for both hydrophilic and hydrophobic drugs. This review explores the types of self-assembling nanostructures, the effects of external stimuli on and the mechanisms behind the assembly process, and applications for such technology in drug delivery.
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Katoriya, V. S., G. S. Deokar, and S. J. Kshirsagar. "IONOTROPIC TRAPPING LECITHIN BASED CILOSTAZOL NANOCOCHLEATES FOR DRUG DELIVERY APPLICATIONS." INDIAN DRUGS 54, no. 09 (September 28, 2017): 24–32. http://dx.doi.org/10.53879/id.54.09.10682.

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The nanocochleate drug delivery is based on encapsulating drugs in multilayered lipid crystal matrix (a cochleate) to potentially deliver the drug safely and effectively through the lipoidal membrane. Cilostazol is approved for the treatment of intermittent claudication and used as fibrinolytic agent, platelet aggregation inhibitor, bronchodilator agent, phosphodiesterase III Inhibitor and vasodilator agent. therefore, this drug delivery is suitable to deliver drug molecules into blood vessels. Formulations with lecithin showed good in vitro drug release, drug entrapment study results and the drug in formulations was found to be intact and compatible with lipids used. Two optimized formulations containing cilostazol lecithin-cholesterol showed Korsemayer peppas model perfect zero order release and showed better sustained and controlled drug release. Lecithin-cholesterol nanocochleates prepared by external ionotropic trapping method was found to be better ionic cross linking of drug-lipids particles. Therefore, ionotropic cross-linked particles are promising carriers for oral controlled release dosage forms.
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Heggannavar, Geetha B., Divya Achari, Cristiana Fernandes, Geoffrey R. Mitchell, Pedro Morouço, and Mahadevappa Y. Kariduraganavar. "Smart Polymers in Drug Delivery Applications." Applied Mechanics and Materials 890 (April 2019): 324–39. http://dx.doi.org/10.4028/www.scientific.net/amm.890.324.

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The most important components of living cells such as carbohydrates, proteins and nucleic acids are the polymeric molecules. Nature utilizes polymers both as constructive elements and as a part of the complicated cell machinery of living things. The rapid advancement in biomedical research has led to many creative applications for biocompatible polymers. With the development of newer and more potent drugs, a parallel expansion in more sophisticated drug delivery systems becomes mandatory. Smart polymeric drug-delivery systems have the ability to respond to environmental changes and consequently, alter their properties reversibly enabling an efficient and safe drug delivery. This review comprehensively discusses various aspects of these polymers classified in different categories as per the type of stimulus.
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Antimisiaris, Sophia G. "Arsonoliposomes for drug delivery applications." Clinical Lipidology 4, no. 5 (October 2009): 663–75. http://dx.doi.org/10.2217/clp.09.42.

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Дисертації з теми "Drug Delivery Applications"

1

Banerjee, Abhishek. "Functionalizable Biodegradable Polyesters for Drug Delivery Applications." University of Akron / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=akron1335240206.

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Tamames, Tabar Cristina. "Metal-organic frameworks for drug delivery applications." Thesis, Versailles-St Quentin en Yvelines, 2014. http://www.theses.fr/2014VERS0006/document.

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Ce travail de thèse est centré sur l’étude d’un nouveau type de matériau, les solideshybrides cristallins MOFs (ou Metal-Organic Frameworks) comme systèmes devectorisation de médicaments.Tout d’abord, les MOFs ont été synthétisés à l’échelle nanométrique (NP), en utilisant desméthodes biocompatibles, quand possible. Leur cytotoxicité, ainsi que celle de leursligands constitutifs, a été évaluée par le test MTT sur des macrophages murins (J774) etdu carcinome cervical (HeLa). Nous avons pu constater: (i) une faible cytotoxicité desMOFs, comparable à celle d’autres particules commercialisées, (ii) une influenceimportante de la composition du MOF (ordre de toxicité: Fe
In this work, a new type of particles denoted as MOFs or Metal-Organic Frameworks, havebeen studied as a new drug carriers.First, they were synthesised at the nanoscale (NPs) using, when possible, biofriendlymethods. Their cytotoxicity, as well as that from their constitutive linkers, was evaluatedby the MTT test in murine macrophage (J774) and in cervix carcinoma (HeLa) cell lines,observing: (i) a low cytotoxicity of MOFs, comparable with other described particulatedsystems, (ii) a strong influence of the composition (toxicity order: Fe
En este trabajo, se han estudiado un nuevo tipo de partículas denominadas MOFs oMetal-Organic Frameworks como transportadores de fármacos.Primero, se sintetizaron en escala nanométrica (NP) sustituyendo los disolventes tóxicoscuando fuese posible. Se evaluó su citotoxicidad, así como la de sus ligandos, mediante eltest de MTT en las líneas celulares J774 (macrófagos murinos) y en HeLa (carcinoma decérvix), observando: (i) una baja citotoxicidad de los MOFs, comparable a otros sistemasparticulados, (ii) una fuerte influencia de su composición (orden de toxicidad: Fe
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Frost, S. J. "Analytical applications of liposomes." Thesis, University of Surrey, 1994. http://epubs.surrey.ac.uk/2745/.

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Liposomes have established roles in drug delivery and cell membrane studies. Amongst other applications; they can also be used as analytical reagents, particularly in immunoassays. Liposomal immunoassays have potential advantages over alternatives; including sensitivity, speed, simplicity and relative reagent stability. The aim of these studies was to develop and evaluate novel examples of these assays. When liposomes entrapped the dye, Sulphorhodamine B, a shift in its maximum absorption wavelength compared to free dye was observed. This was attributed to dimerization of the dye at high concentrations. If the liposomes were disrupted, the released dye was diluted into the external buffer, and the dye's absorption spectrum reverted to that of free dye. After optimization of dye entrapment, immunoassays were developed using these liposomes. Albumin-coated liposomes were used in a model assay to measure serum albumin. This assay employed complement-mediated immunolysis, commonly used in liposomal immunoassays. The liposomes were lysed by anti-albumin and complement, and this could be competitively inhibited by serum albumin. To improve sensitivity, Fab' anti-albumin liposomes were prepared. These enabled measurement of urinary albumin by a complement-mediated immunoassay, but using a sandwich technique. Anti-albumin (intact) liposomes were shown to precipitate on gentle centrifugation after reaction with albumin. They were applied as a solid phase reagent in an heterogeneous immunoassay, using radioimmunoassay for urinary microalbumin as a model assay. Liposomes containing Sulphorhodamine B were also used in a more novel assay; for serum anticardiolipin antibodies. Cardiolipin-containing liposomes were prepared. These were lysable using magnesium ions. Anticardiolipin antibodies (IgG) were found to augment this lysis, enabling their estimation. Similar imprecision and acceptable correlation with a commercial enzyme-linked immunosorbent assay (ELISA) were obtained. The findings demonstrate Sulphorhodamine B release can be used as a marker in homogeneous colorimetric liposomal immunoassays; both in model assays and in potentially more useful clinical biochemistry applications.
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Ostroha, Jamie L. Lowman Anthony M. Dan Nily. "PEG-based degradable networks for drug delivery applications /." Philadelphia, Pa. : Drexel University, 2006. http://dspace.library.drexel.edu/handle/1860%20/842.

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Kumar, Dhiraj. "Co-Functionalised Gold Nanoparticles for Drug Delivery Applications." Thesis, Ulster University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.649271.

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Benzeval, Ian. "Development of responsive polymers for drug delivery applications." Thesis, University of Bath, 2009. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500696.

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In this thesis, glucose responsive hydrogels based on cross-linked dextran molecules were studied to determine the diffusion rate of an insulin analogue. Investigations of the interaction between concanavalin A and dextran, both in free solution and in the form of glucose responsive hydrogels were conducted. The free solution results have shown that there is an increase of association constant between concanavalin A and dextran when the molecular mass of the dextran is increased. Free solution viscometric tests have shown that increasing the molecular mass or the concentration of the dextran increases the viscosity. The hydrogels have been shown to form for dextrans of molecular mass 43kD or greater. Experiments conducted with hydrogel membranes in a diffusion cell have shown that the batch to batch reproducibility of hydrogel transport properties is low. However, clear evidence of glucose enhanced transport was obtained and these results were compared with predictions obtained from a theoretical model of gel permeability that accounts for competitive displacement of affinity cross links. Oscillatory rheological tests of gelation mixtures which showed an increase in complex viscosity at the gel point with increasing molecular mass of dextran were in agreement with empirical observations that gels formed from the highest molecular mass dextrans were more physically robust and easier to handle. Swelling rate experiments have shown that the rate of hydration of a hydrogel in the presence of glucose is decreased due to the osmotic pressure of the glucose. This work has shown that the multivalent nature of concanavalin A may not be a necessary pre-requisite for this type of hydrogel due to spatial constraints decreasing the number of potential affinity bonds per tetramer. In-house production of more tightly defined dextrans might be expected to reduce heterogeneity and improve the reproducibility of this type of hydrogel membrane.
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Mitragotri, Samir. "Ultrasound-mediated transdermal drug delivery : mechanisms and applications." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/11263.

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Green, Da'Sean Edward. "Trehalose-Stabilized Polymer Assemblies for Drug Delivery Applications." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu150332742091042.

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Roberts, Rose A. "Polymer Nanoparticle Characterization and Applications for Drug Delivery." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/104384.

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Nanoparticle usage continues to increase in everyday products, from cosmetics to food preservation coatings, drug delivery to polymer fillers. Their characterization and synthesis is of utmost importance to ensure safety and improved product quality. Nanoparticles can be sourced naturally or synthetically fabricated. Cellulose nanocrystals (CNCs) are rod-like nanoparticles that can be isolated from nature. Reliable methods of characterization are necessary to ensure quality control. However, their physical characteristics cause challenges for imaging under transmission electron microscopy (TEM) with a high enough resolution for dimensional analysis. Heavy metal staining such as radioactive uranyl acetate is often used to increase contrast and TEM sample substrate preparation techniques often use expensive equipment such as glow discharge in order to prevent CNC agglomeration. A method to reliably produce TEM images of CNCs without using radioactive stains or expensive glow discharge equipment was developed, using a vanadium-based stain branded NanoVan® and bovine serum albumin to keep CNCs dispersed while drying on the TEM substrate. Due to their aspect ratio, there is also concern of toxicity to the lungs. The concentration of CNCs in air in production facilities must be monitored, but there is currently no method tailored to CNCs. A method using UV-vis spectroscopy, dynamic light scattering, TEM, and scanning mobility particle sizer in conjunction with impinger collectors was developed for monitoring aerosolized CNC concentration. Synthetic nanoparticles are often used for controlled drug delivery systems. A new peptide drug termed αCT1 has been shown to interact with cell communication in a way that promotes wound healing, reduces inflammation and scarring, and aids in cancer therapy. However, the peptide�s half-life in the body is estimated to be less than a day, which is not conducive to long-term treatments. Controlling its release into the body over several weeks can decrease the number of doses required, which is especially useful for glioblastoma treatment. Poly(lactic-co-glycolic acid) (PLGA) is often used for drug encapsulation since it hydrolyzes in the body and is biocompatible. Two methods of αCT1 encapsulation in PLGA were explored. It was found that flash nanoprecipitation increased loading of αCT1 in the particles by 1-2 orders of magnitude compared with the double emulsion method. Particles released αCT1 over three weeks and were non-cytotoxic.
PHD
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Datt, Ashish. "Applications of mesoporous silica and zeolites for drug delivery." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/3442.

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Zeolites and mesoporous silica were used as drug delivery systems for the loading and release of small drug molecules, aspirin and 5-fluorouracil. Different parameters were varied such as aluminum content in the zeolite, effect of distribution of functional groups and the method of surface modification in case of mesoporous silica. The effect of the aforementioned variables was studied on drug loading and release from these microporous and mesoporous systems. The drug loaded materials were extensively characterized using various physical techniques such as powder X-ray diffraction, nitrogen isotherms, infrared spectroscopy, solid state NMR and thermogravimetric analysis. Quantum calculations and molecular dynamics simulations were performed in order to validate the experimental data and also to obtain a molecular level insight of the drugs inside the pores of the host materials. Drug templated synthesis of mesoporous silica was also carried out in the presence of aspirin as the template. The aspirin templated material was characterized by aforementioned techniques and showed a sustained drug release profile.
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Книги з теми "Drug Delivery Applications"

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M, Ottenbrite Raphael, and Chiellini Emo, eds. Polymers in medicine: Biomedical and pharmaceutical applications. Lancaster, PA: Technomic Pub. Co., 1992.

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Li, Chun, and Mei Tian, eds. Drug Delivery Applications of Noninvasive Imaging. Hoboken, NJ: John Wiley & Sons, Inc, 2013. http://dx.doi.org/10.1002/9781118356845.

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Svenson, Sonke, and Robert K. Prud'homme, eds. Multifunctional Nanoparticles for Drug Delivery Applications. Boston, MA: Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-2305-8.

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1939-, Robinson Joseph R., and Lee, Vincent H. L., 1951-, eds. Controlled drug delivery: Fundamentals and applications. 2nd ed. New York: Dekker, 1987.

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5

H, Marchessault R., Ravenelle François, Zhu Xiao Xia, American Chemical Society. Cellulose and Renewable Materials Division., and American Chemical Society Meeting, eds. Polysaccharides for drug delivery and pharmaceutical applications. Washington, DC: American Chemical Society, 2006.

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6

Kurkuri, Mahaveer, Dusan Losic, U. T. Uthappa, and Ho-Young Jung. Advanced Porous Biomaterials for Drug Delivery Applications. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003217114.

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Chen, Jin, Ling Chen, Fengwei Xie, and Xiaoxi Li. Drug Delivery Applications of Starch Biopolymer Derivatives. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-3657-7.

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Marchessault, Robert H., François Ravenelle, and Xiao Xia Zhu, eds. Polysaccharides for Drug Delivery and Pharmaceutical Applications. Washington, DC: American Chemical Society, 2006. http://dx.doi.org/10.1021/bk-2006-0934.

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Addo, Richard T., ed. Ocular Drug Delivery: Advances, Challenges and Applications. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-47691-9.

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Svenson, Sonke. Multifunctional Nanoparticles for Drug Delivery Applications: Imaging, Targeting, and Delivery. Boston, MA: Springer US, 2012.

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Частини книг з теми "Drug Delivery Applications"

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Ito, Yoshihiro. "Drug Delivery Systems." In Photochemistry for Biomedical Applications, 231–75. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-0152-0_9.

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Khandare, Jayant, and Rainer Haag. "Pharmaceutically Used Polymers: Principles, Structures, and Applications of Pharmaceutical Delivery Systems." In Drug Delivery, 221–50. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00477-3_8.

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Adams, Ralph N. "Applications of Miniature Electrodes to Biomedical Studies." In Directed Drug Delivery, 309–17. Totowa, NJ: Humana Press, 1985. http://dx.doi.org/10.1007/978-1-4612-5186-6_17.

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Venugopal, Indu, Ankit I. Mehta, and Andreas A. Linninger. "Drug Delivery Applications of Nanoparticles in the Spine." In Drug Delivery Systems, 121–43. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9798-5_5.

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Lowman, Anthony M. "Biomaterials in Drug Delivery." In Biomedical Devices and Their Applications, 1–31. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-662-06108-4_1.

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Manzano, Miguel. "Ceramics for Drug Delivery." In Bio-Ceramics with Clinical Applications, 343–82. Chichester, UK: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118406748.ch12.

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Bhatia, Saurabh. "Advance Polymers and Its Applications." In Systems for Drug Delivery, 119–46. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-41926-8_4.

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Lins, Paula M. P., Laís Ribovski, Isabella Sampaio, Olavo A. Santos, Valtencir Zucolotto, and Juliana Cancino-Bernardi. "Inorganic Nanoparticles for Biomedical Applications." In Nanocarriers for Drug Delivery, 49–72. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63389-9_3.

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Rehman, Nahid, and Anjana Pandey. "Nanoparticle Application in Non-Parenteral Applications." In Engineered Nanoparticles as Drug Delivery Systems, 67–78. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003252122-7.

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Newman, Stephen P. "IMAGING PULMONARY DRUG DELIVERY." In Drug Delivery Applications of Noninvasive Imaging, 333–66. Hoboken, NJ: John Wiley & Sons, Inc, 2013. http://dx.doi.org/10.1002/9781118356845.ch15.

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Тези доповідей конференцій з теми "Drug Delivery Applications"

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Dickson, Eva F., Rebecca L. Goyan, James C. Kennedy, M. Mackay, M. A. K. Mendes, and Roy H. Pottier. "Protease-mediated drug delivery." In Applications of Photonic Technology, edited by Roger A. Lessard and George A. Lampropoulos. SPIE, 2003. http://dx.doi.org/10.1117/12.543446.

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Marcu, Laura. "Fluorescence Lifetime Techniques In Clinical Applications." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2013. http://dx.doi.org/10.1364/omp.2013.mt3c.1.

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3

Pepperkok, Rainer, and Christian Tischer. "High Throughput Microscopy For Sytems Biology Applications." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2013. http://dx.doi.org/10.1364/omp.2013.mm4c.1.

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4

Lin, Christie. "Applications of a Novel Translational Fluorescence-guided Surgery Platform." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2021. http://dx.doi.org/10.1364/omp.2021.om3e.1.

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5

Cooper, Daniel B., and Pavlos P. Vlachos. "Parametric Investigation of Magnetic Particle Transport for Targeted Drug Delivery Applications." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53889.

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Анотація:
In recent years, there has been significant clinical and research interest in magnetic drug targeting (MDT). MDT allows the targeted delivery of drugs only to the affected sites, alleviating the rest of the body from the potential toxic or other side effects of the drug. The underlying concept of MDT is to attach drugs to small magnetic particles which can then be manipulated by a magnetic field designed to attract the drug carrying particles to the target site [1]. This will lead to increasing localized accumulation of the drug at the target site. MDT can have great implications on pharmaceutical treatments, ranging from oncology to cardiology and beyond [2, 3].
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6

Moussi, Khalil, Mohammed AlDajani, and Jurgen Kosel. "Miniaturized Drug Delivery System for Biomedical Applications." In 2019 IEEE 14th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS). IEEE, 2019. http://dx.doi.org/10.1109/nems.2019.8915621.

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7

Breland, Matthew, Badal Patel, and Hassan Bajwa. "Engineered nanoparticles for targeted drug delivery." In 2012 IEEE Long Island Systems, Applications and Technology Conference (LISAT). IEEE, 2012. http://dx.doi.org/10.1109/lisat.2012.6223198.

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Blanco, Letia, Panos S. Shiakolas, Pranesh B. Aswath, Christopher B. Alberts, Chris Grace, Kyle Godfrey, and Drew Patin. "A Thermoresponsive Hydrogel Based Controlled Drug Delivery Device." In ASME 2012 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/imece2012-88564.

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Thermoresponsive hydrogels exhibit the unique property of volume change as a function of change in temperature as they transition between hydrophilic and hydrophobic states. These hydrogels can be loaded with drug/protein and serve as reservoirs for drug/protein delivery applications. A hydrogel based device for controlled drug delivery is designed with a number of subsystems that are interfaced with LabVIEW for development of a functional device. The device was designed using analytical and finite element analysis procedures and fabricated. In this manuscript, the device design will be reviewed and discussed. A parametric study was performed to examine the device operation and performance as function of hydrogel heating/cooling temperature profiles. Subsequently, the device was employed in a series of experiments to examine the delivery of a protein as a function of thermal stimuli. The matrix used in this study was poly(ethylene glycol) diacrylate (PEGDA) and the drug delivery nanoparticles carriers were poly(N-isopropylacrylamide-co-acrylamide (PNIPAM) with a lower critical solution temperature (LCST) around 40°C. The protein of choice was bovine serum albumin (BSA). The results of this study illustrate that the development of a multi-drug or therapeutic delivery device is possible and that individual drugs can be delivered on demand using a closed loop control system.
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Song, Shang, Yupeng Chen, Hicham Fenniri, and Thomas J. Webster. "A novel drug delivery device for orthopedic applications." In 2010 36th Annual Northeast Bioengineering Conference. IEEE, 2010. http://dx.doi.org/10.1109/nebc.2010.5458247.

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Sehgal, Drishti Navin, Stephen Kalscheuer, and Jayanth Panyam. "Abstract 2167: Antibody glycoengineering for drug delivery applications." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2167.

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Звіти організацій з теми "Drug Delivery Applications"

1

Radu, Daniela Rodica. Mesoporous Silica Nanomaterials for Applications in Catalysis, Sensing, Drug Delivery and Gene Transfection. Office of Scientific and Technical Information (OSTI), January 2004. http://dx.doi.org/10.2172/837277.

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