Готові списки джерел за темами / DNA strand

Добірка наукової літератури з теми "DNA strand"

Автор: Grafiati
Опубліковано: 7 липня 2024
Оновлено: 7 липня 2024

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Статті в журналах з теми "DNA strand":

1

Maslowska, Katarzyna H., Karolina Makiela-Dzbenska, Jin-Yao Mo, Iwona J. Fijalkowska, and Roel M. Schaaper. "High-accuracy lagging-strand DNA replication mediated by DNA polymerase dissociation." Proceedings of the National Academy of Sciences 115, no. 16 (April 2, 2018): 4212–17. http://dx.doi.org/10.1073/pnas.1720353115.

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The fidelity of DNA replication is a critical factor in the rate at which cells incur mutations. Due to the antiparallel orientation of the two chromosomal DNA strands, one strand (leading strand) is replicated in a mostly processive manner, while the other (lagging strand) is synthesized in short sections called Okazaki fragments. A fundamental question that remains to be answered is whether the two strands are copied with the same intrinsic fidelity. In most experimental systems, this question is difficult to answer, as the replication complex contains a different DNA polymerase for each strand, such as, for example, DNA polymerases δ and ε in eukaryotes. Here we have investigated this question in the bacterium Escherichia coli, in which the replicase (DNA polymerase III holoenzyme) contains two copies of the same polymerase (Pol III, the dnaE gene product), and hence the two strands are copied by the same polymerase. Our in vivo mutagenesis data indicate that the two DNA strands are not copied with the same accuracy, and that, remarkably, the lagging strand has the highest fidelity. We postulate that this effect results from the greater dissociative character of the lagging-strand polymerase, which provides additional options for error removal. Our conclusion is strongly supported by results with dnaE antimutator polymerases characterized by increased dissociation rates.
2

Shi, Jiezhong, Ben Zhang, Tianyi Zheng, Tong Zhou, Min Guo, Ying Wang, and Yuanchen Dong. "DNA Materials Assembled from One DNA Strand." International Journal of Molecular Sciences 24, no. 9 (May 3, 2023): 8177. http://dx.doi.org/10.3390/ijms24098177.

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Due to the specific base-pairing recognition, clear nanostructure, programmable sequence and responsiveness of the DNA molecule, DNA materials have attracted extensive attention and been widely used in controlled release, drug delivery and tissue engineering. Generally, the strategies for preparing DNA materials are based on the assembly of multiple DNA strands. The construction of DNA materials using only one DNA strand can not only save time and cost, but also avoid defects in final assemblies generated by the inaccuracy of DNA ratios, which potentially promote the large-scale production and practical application of DNA materials. In order to use one DNA strand to form assemblies, the sequences have to be palindromes with lengths that need to be controlled carefully. In this review, we introduced the development of DNA assembly and mainly summarized current reported materials formed by one DNA strand. We also discussed the principle for the construction of DNA materials using one DNA strand.
3

Jensen, Sarah Ø., Nadia Øgaard, Hans Jørgen Nielsen, Jesper B. Bramsen, and Claus L. Andersen. "Enhanced Performance of DNA Methylation Markers by Simultaneous Measurement of Sense and Antisense DNA Strands after Cytosine Conversion." Clinical Chemistry 66, no. 7 (May 27, 2020): 925–33. http://dx.doi.org/10.1093/clinchem/hvaa100.

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Abstract Background Most existing DNA methylation-based methods for detection of circulating tumor DNA (ctDNA) are based on conversion of unmethylated cytosines to uracil. After conversion, the 2 DNA strands are no longer complementary; therefore, targeting only 1 DNA strand merely utilizes half of the available input DNA. We investigated whether the sensitivity of methylation-based ctDNA detection strategies could be increased by targeting both DNA strands after bisulfite conversion. Methods Dual-strand digital PCR assays were designed for the 3 colorectal cancer (CRC)–specific methylation markers KCNQ5, C9orf50, and CLIP4 and compared with previously reported single-strand assays. Performance was tested in tumor and leukocyte DNA, and the ability to detect ctDNA was investigated in plasma from 43 patients with CRC stages I to IV and 42 colonoscopy-confirmed healthy controls. Results Dual-strand assays quantified close to 100% of methylated control DNA input, whereas single-strand assays quantified approximately 50%. Furthermore, dual-strand assays showed a 2-fold increase in the number of methylated DNA copies detected when applied to DNA purified from tumor tissue and plasma from CRC patients. When the results of the 3 DNA methylation markers were combined into a ctDNA detection test and applied to plasma, the dual-strand assay format detected 86% of the cancers compared with 74% for the single-strand assay format. The specificity was 100% for both the dual- and single-strand test formats. Conclusion Dual-strand assays enabled more sensitive detection of methylated ctDNA than single-strand assays.
4

Fan, Xinqing, and Carolyn Mary Price. "Coordinate Regulation of G- and C Strand Length during New Telomere Synthesis." Molecular Biology of the Cell 8, no. 11 (November 1997): 2145–55. http://dx.doi.org/10.1091/mbc.8.11.2145.

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We have used the ciliate Euplotes to study the role of DNA polymerase in telomeric C strand synthesis.Euplotes provides a unique opportunity to study C strand synthesis without the complication of simultaneous DNA replication because millions of new telomeres are made at a stage in the life cycle when no general DNA replication takes place. Previously we showed that the C-strands of newly synthesized telomeres have a precisely controlled length while the G-strands are more heterogeneous. This finding suggested that, although synthesis of the G-strand (by telomerase) is the first step in telomere addition, a major regulatory step occurs during subsequent C strand synthesis. We have now examined whether G- and C strand synthesis might be regulated coordinately rather than by two independent mechanisms. We accomplished this by determining what happens to G- and C strand length if C strand synthesis is partially inhibited by aphidicolin. Aphidicolin treatment caused a general lengthening of the G-strands and a large increase in C strand heterogeneity. This concomitant change in both the G- and C strand length indicates that synthesis of the two strands is coordinated. Since aphidicolin is a very specific inhibitor of DNA polα and polδ, our results suggest that this coordinate length regulation is mediated by DNA polymerase.
5

Ma, Jingjing. "Molecular Logic Gate Based on DNA Strand Displacement Reaction." Journal of Nanoelectronics and Optoelectronics 16, no. 6 (June 1, 2021): 974–77. http://dx.doi.org/10.1166/jno.2021.3037.

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In this paper, I construct an XOR logic gate based on DNA strand displacement reaction, and verify our design through corresponding biochemical experiment. I designed several different DNA strands. Based on two basic DNA strand displacement reaction mechanisms, by adding different input strands and taking the signal of FAM fluorescent group as the output, the XOR logic gate is realized. The result shows that DNA strand displacement technology has important application value in DNA computing, especially in the construction of DNA molecular logic gates.
6

Sugiman-Marangos, Seiji N., Yoni M. Weiss, and Murray S. Junop. "Mechanism for accurate, protein-assisted DNA annealing by Deinococcus radiodurans DdrB." Proceedings of the National Academy of Sciences 113, no. 16 (April 4, 2016): 4308–13. http://dx.doi.org/10.1073/pnas.1520847113.

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Accurate pairing of DNA strands is essential for repair of DNA double-strand breaks (DSBs). How cells achieve accurate annealing when large regions of single-strand DNA are unpaired has remained unclear despite many efforts focused on understanding proteins, which mediate this process. Here we report the crystal structure of a single-strand annealing protein [DdrB (DNA damage response B)] in complex with a partially annealed DNA intermediate to 2.2 Å. This structure and supporting biochemical data reveal a mechanism for accurate annealing involving DdrB-mediated proofreading of strand complementarity. DdrB promotes high-fidelity annealing by constraining specific bases from unauthorized association and only releases annealed duplex when bound strands are fully complementary. To our knowledge, this mechanism provides the first understanding for how cells achieve accurate, protein-assisted strand annealing under biological conditions that would otherwise favor misannealing.
7

Bolt, Edward L., and Thorsten Allers. "New enzymes, new mechanisms?: DNA repair by recombination in the Archaea." Biochemist 26, no. 3 (June 1, 2004): 19–21. http://dx.doi.org/10.1042/bio02603019.

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DNA repair by homologous recombination is highly accurate, since it uses an intact DNA strand to guide repair of its damaged homologue. This article focuses on two key steps in recombination: unwinding of strands by repair helicases, and annealing of homologous strands by strand-exchange enzymes.
8

Domljanovic, Ivana, Alessandro Ianiro, Curzio Rüegg, Michael Mayer, and Maria Taskova. "Natural and Modified Oligonucleotide Sequences Show Distinct Strand Displacement Kinetics and These Are Affected Further by Molecular Crowders." Biomolecules 12, no. 9 (September 6, 2022): 1249. http://dx.doi.org/10.3390/biom12091249.

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DNA and RNA strand exchange is a process of fundamental importance in biology. Herein, we used a FRET-based assay to investigate, for the first time, the stand exchange kinetics of natural DNA, natural RNA, and locked nucleic acid (LNA)-modified DNA sequences in vitro in PBS in the absence or presence of molecular additives and macromolecular crowders such as diethylene glycol dimethyl ether (deg), polyethylene glycol (peg), and polyvinylpyrrolidone (pvp). The results show that the kinetics of strand exchange mediated by DNA, RNA, and LNA-DNA oligonucleotide sequences are different. Different molecular crowders further affect the strand displacement kinetics, highlighting the complexity of the process of nucleic acid strand exchange as it occurs in vivo. In a peg-containing buffer, the rate constant of displacement was slightly increased for the DNA displacement strand, while it was slightly decreased for the RNA and the LNA-DNA strands compared with displacement in pure PBS. When we used a deg-containing buffer, the rate constants of displacement for all three sequences were drastically increased compared with displacement in PBS. Overall, we show that interactions of the additives with the duplex strands have a significant effect on the strand displacement kinetics and this effect can exceed the one exerted by the chemical nature of the displacement strand itself.
9

Cronan, Glen E., Elena A. Kouzminova, and Andrei Kuzminov. "Near-continuously synthesized leading strands inEscherichia coliare broken by ribonucleotide excision." Proceedings of the National Academy of Sciences 116, no. 4 (January 7, 2019): 1251–60. http://dx.doi.org/10.1073/pnas.1814512116.

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In vitro, purified replisomes drive model replication forks to synthesize continuous leading strands, even without ligase, supporting the semidiscontinuous model of DNA replication. However, nascent replication intermediates isolated from ligase-deficientEscherichia colicomprise only short (on average 1.2-kb) Okazaki fragments. It was long suspected that cells replicate their chromosomal DNA by the semidiscontinuous mode observed in vitro but that, in vivo, the nascent leading strand was artifactually fragmented postsynthesis by excision repair. Here, using high-resolution separation of pulse-labeled replication intermediates coupled with strand-specific hybridization, we show that excision-proficientE. coligenerates leading-strand intermediates >10-fold longer than lagging-strand Okazaki fragments. Inactivation of DNA-repair activities, including ribonucleotide excision, further increased nascent leading-strand size to ∼80 kb, while lagging-strand Okazaki fragments remained unaffected. We conclude that in vivo, repriming occurs ∼70× less frequently on the leading versus lagging strands, and that DNA replication inE. coliis effectively semidiscontinuous.
10

Delagoutte, Emmanuelle, and Giuseppe Baldacci. "5′CAG and 5′CTG Repeats Create Differential Impediment to the Progression of a Minimal Reconstituted T4 Replisome Depending on the Concentration of dNTPs." Molecular Biology International 2011 (August 10, 2011): 1–14. http://dx.doi.org/10.4061/2011/213824.

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Instability of repetitive sequences originates from strand misalignment during repair or replicative DNA synthesis. To investigate the activity of reconstituted T4 replisomes across trinucleotide repeats (TNRs) during leading strand DNA synthesis, we developed a method to build replication miniforks containing a TNR unit of defined sequence and length. Each minifork consists of three strands, primer, leading strand template, and lagging strand template with a 5′ single-stranded (ss) tail. Each strand is prepared independently, and the minifork is assembled by hybridization of the three strands. Using these miniforks and a minimal reconstituted T4 replisome, we show that during leading strand DNA synthesis, the dNTP concentration dictates which strand of the structure-forming 5′CAG/5′CTG repeat creates the strongest impediment to the minimal replication complex. We discuss this result in the light of the known fluctuation of dNTP concentration during the cell cycle and cell growth and the known concentration balance among individual dNTPs.
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Статті в журналах Дисертації Книги

Дисертації з теми "DNA strand":

1

Lo, Allen Tak Yiu. "Protein dynamics on the lagging strand during DNA synthesis." Thesis, School of Chemistry, 2012. https://ro.uow.edu.au/theses/3684.

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DNA replication is one of the vital processes in the cell; it duplicates chromosomal DNA before a cell divides. In all organisms, DNA synthesis on the leading-strand template occurs continuously, whereas on the lagging strand a different mechanism is required. Due to the anti-parallel structure of double-stranded DNA, lagging-strand synthesis requires repeated RNA priming by a specialist primase and synthesis of short Okazaki fragments. How proteins carry out this dynamic process is still unknown. For Escherichia coli DNA replication, a lagging-strand three-point switch was proposed in 1999 to explain priming by DnaG primase while it is associated with the DnaB6 helicase, and its subsequent hand-off from the primer to the χ subunit of DNA polymerase III holenzyme to enable primer utilization for Okazaki fragment synthesis. The main aims of this project were to study the interactions involved in this switch to understand better how the proteins coordinate their roles during lagging-strand DNA synthesis.
2

Tingey, Andrew Philip. "Strand passage in DNA gyrase." Thesis, University of Leicester, 1996. http://hdl.handle.net/2381/35173.

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DNA gyrase, a type II topoisomerase, catalyses the introduction of negative supercoils into closed-circular DNA, using the energy from ATP hydrolysis. The reaction mechanism involves the breakage of one DNA double strand (the DNA gate) and the passing of another DNA strand (the passage helix) through that break and finally the re-sealing of the DNA gate. The strand-passage reaction was studied by the use of novel DNA substrates and by site-directed mutagenesis of one of the gyrase proteins. The DNA substrates were used to attempt to define the DNA segments used by the enzyme as the DNA gate and passage helix in a catenation reaction. This was achieved by using oligonucleotides to form partial duplex regions in single-stranded DNA. A high-affinity gyrase cleavage site from the plasmid pBR322 was cloned into M13mpl8 and generated both the single and double-stranded circular forms of the molecule (MAT1). It was shown that gyrase could form a specific DNA gate in a short duplex region in single-stranded MAT1 when quinolone drugs were present. This DNA gate was much smaller than that normally utilised by the enzyme. The catenation and decatenation reactions were examined in detail with normal duplex substrates; reactions using a non-hydrolysable ATP analogue gave different results to those previously reported for the eukaryotic homologue of gyrase, indicating a possible mechanistic difference between the enzymes. Conditions under which the partial duplex substrates would be catenated were not found. Site-directed mutagenesis was used to alter arginine residues thought to interact with the passage helix during the reaction cycle. Assays of the mutant protein revealed that supercoiling activity was markedly reduced, but that partial activities of gyrase, such as the ATPase and DNA cleavage reactions, were close to wild-type levels.
3

Ho, F. M. "Strand exchange for duplex DNA detection." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604106.

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The phenomenon of strand exchange between an unlabelled double-stranded target oligonucleotide and a single-stranded, fluorophore labelled probe oliognucleotide was investigated. This behaviour was characterised using fluorescence resonance energy transfer (FRET). The individual fluorescence characteristics of the fluorophores the minor-groove binder Hoechst 33258 and the dye Oregon Green 488 were studied, as well as their properties in combination as a FRET pair. These dyes allowed the use of FRET for the study of duplex DNA without the need for covalently attaching two labels on the component strands. Two strategies were studied for the detection of a duplex target. Firstly, detection could be by monitoring the FRET process as a function of time, monitoring the fluorescence intensities at both the donor and acceptor emission peak wavelengths. Single base pair discrimination was achieved, with very high reproducibility, especially if ratiometric analysis of the emission signals was employed. The mechanism of this process was examined using mathematical modelling, and comparisons made with the experimental results. Secondly, an in-gel detection technique was investigated for the detection of the target duplex within a complex mixture. The target sequence was successfully detected from within the enzyme digestion products of plasmids extracted from cloned E. coli cells. This was performed directly from a polyacrylamide electrophoresis gel without the need for blotting, and was possible with or without polymerase chain reaction amplification. Multiplexing was also demonstrated using this in-gel strategy, giving simultaneous detection of two targets of different base sequences and lengths. Finally, the synthesis of an acceptor fluorophore labelled dendrimer was proposed. This opened up the prospect of exploiting the properties of the dendrimer to enhance the FRET signal upon strand exchange.
4

Washbrook, Elinor. "Alternate strand DNA triple helix formation." Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242223.

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5

Lansita, Janice A. (Janice Ann) 1975. "Physicochemical characterization of immortal strand DNA." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/18038.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2004.
Includes bibliographical references.
Adult tissue differentiation involves the generation of distinct cell types from adult stem cells (ASCs). Current understanding of tissue differentiation mechanisms is based on studies of protein and RNAs that asymmetrically segregate between daughter cells during embryogenesis. Whether or not other types of biomolecules segregate asymmetrically has not been widely studied. In 1975, John Cairns proposed that ASCs preferentially segregate the oldest parental template DNA strands to themselves and pass on newly replicated DNA strands to their differentiating progeny in order to protect the stem cell from inheriting DNA replication mutations. This laboratory has shown non-random chromosome segregation in murine fetal fibroblasts that model asymmetric self-renewal like ASCs. In these cells, chromosomes that contain the oldest DNA strands co-segregate to the cycling daughter stem-like cells, while chromosomes with more recently replicated DNA segregate to the non-stem cell daughters. Previously, cytological methods were reported to elucidate non-random segregation in these cells. This dissertation research provides additional confirmation of the mechanism using physicochemical methods. Specifically, buoyant density-shift experiments in equilibrium CsCl density gradients were used to detect co-segregated "immortal DNA strands" based on incorporation of the thymidine base analogue bromodeoxyuridine. In addition, DNA from cells undergoing non-random mitotic chromosome segregation was analyzed for unique DNA base modifications and global structural modifications (by HPLC and melting temperature analyses). To date, these studies show no significant differences compared to control randomly segregated DNA. Components of the mitotic chromosome separation
(cont.) apparatus that might play a role in the co-segregation mechanism were also evaluated. Two homologous proteins, essential for proper chromosome segregation and cytokinesis, Aurora A kinase and Aurora B kinase, were highly reduced in expression in cells retaining immortal DNA strands and may indicate a role for them in the immortal strand mechanism. These studies independently confirm the immortal strand mechanism and provide methods for its detection in other cell lines. In addition, observed changes in chromosome segregation proteins that are potential candidates for involvement in the mechanism have revealed a new area of investigation in the laboratory. These findings are relevant to understanding normal tissue development, cancer, and aging.
y Janice A. Lansita.
Ph.D.
6

Absalon, Michael Joseph. "DNA double-strand cleavage mediated by bleomycin." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/11927.

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7

Morant, Nick. "Novel thermostable DNA polymerases for isothermal DNA amplification." Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667735.

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DNA polymerases play a fundamental role in the transmission and maintenance of genetic information and have become an important in vitro diagnostic and analytical tool. The Loop-mediated isothermal DNA amplification (LAMP) method has major applications for disease and pathogen detection and utilises the unique strand-displacement activity of a small group of thermostable DNA polymerases. The Large (Klenow-like) Fragment of Geobacillus stearothermophilus DNA polymerase I (B.st LF Pol I) currently serves as the enzyme of choice for the majority of these isothermal reactions, with few alternatives commercially available. An increasing need for point-of-care nucleic acid diagnostics is now shifting detection methods away from traditional laboratory based chemistries, such as the polymerase chain reaction (PCR), in favour of faster, and often simpler, isothermal methods. It was recognised that in order to facilitate these rapid isothermal reactions there was a requirement for alternative thermostable, strand-displacing DNA polymerases and this was the basis of this thesis. This thesis reports the successful identification of polymerases from Family A, chosen for their inherent strand-displacement activity, which is essential for the removal of RNA primers of Okazaki fragments during lagging-strand DNA synthesis in vivo. Twelve thermophilic organisms, with growth temperature ranges between 50oC and 80oC, were identified and the genomic DNA extracted. Where DNA sequences were unavailable, a gene-walking technique revealed the polA sequences, enabling the Large Fragment Pol I to be cloned and the recombinant protein over-expressed in Escherichia coli. A three-stage column chromatography purification permitted the characterisation of ten newly identified Pol I enzymes suitable for use in LAMP. Thermodesulfatator indicus (T.in) Pol I proved to be the most interesting enzyme isolated. Demonstrating strong strand-displacement activity and thermostability to 98oC, T.in Pol I is uniquely suitable to a newly termed heat-denaturing LAMP (HD-LAMP) reaction offering many potential advantages over the existing LAMP protocol. The current understanding of strand-displacement activity of Pol I is poorly understood. This thesis recognised the need to identify the exact regions and motifs responsible for this activity of the enzyme, enabling potential enhancements to be made. Enzyme engineering using site-directed mutagenesis and the formation of chimeras confirmed the importance of specific subdomains in strand-separation activity. With this knowledge, a unique Thermus aquaticus (T.aq) Pol I mutant demonstrated sufficient strand-displacement activity to permit its use in LAMP for the first time. The fusion of Cren7, a double-stranded DNA binding protein, to Pol I for use in LAMP is also reported. Although the fusion construct was found to reduce amplification speed, enhancements were observed in the presence of increased salt concentrations and it is suggested here as a means for future enzyme development.
8

Tatavarthi, Haritha. "Action of Tyrosyl DNA Phosphodiesterase on 3'-Phosphoglycolate Terminated DNA Strand Breaks." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/1799.

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9

Razavy, Haide. "Single-strand DNA ends in recombination in vivo." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq22661.pdf.

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10

Fan, Saijun. "DNA strand breaks induced by gamma-ray irradiation." Thesis, University of Leicester, 1992. http://hdl.handle.net/2381/33667.

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Part I: Plasmid DNA System The effects of a range of buffers and additives on the radiation damage in frozen aqueous plasmid DNA have been studied. In studies of various buffers, the results show that phosphate buffer system sensitise radiation DNA damage, EDTA and Tris present protections against DNA damage, in comparison with pure water system. In studies of other additives, radioprotection by NaI and LiCl increase with increasing concentrations, whilst radiosensitivity of DNA with Na2SO4 and NaClO4 increase with increasing their concentrations. DMSO shows a radioprotection. A range concentrations of spermidine and spermine are used to probe the radioprotection of DNA by polyamines. The results suggest that the protection efficiencies of polyamines increase with increasing their concentrations, moreover, spermine has a greater effect than spermidine. Part II: Cell system 10 mM concentration of spermine shows a radioprotection against DNA DSB and cell death. Metronidazole acts as a sensitiser in the induction of DSB and cell killing. However, spermine-linked metronidazole (AM1229) acts as radioprotectors against DSB under the condition of free-oxygen, and as sensitiser in induction of cell killing under the condition of atmospheric oxygen. The yields of DSBs are compared between cells irradiated at 77K and 0 C. The results show that there is a reduction of DSB in cells exposed at 77K, approximately 35% less than that in cells exposed at 0 C. It may suggest that ca. 65% DNA DSBs formed from direct effect, 35% from indirect effects. There is a difference of DSB yield in cells exposed to gamma-rays in the presence of hypotonic (0.05M) and hypertonic (1.5M) NaCl solutions. The results show that there is 20% increase in hypotonic solution, 8% reduction in hypertonic solution. However, these influences disappear when the cells are irradiated at 77K. The results suggest that the water concentration within cells has an effect on the radiation damage to DNA. There is no evidence to show that an adaptive response of DNA DSB is induced in cell pre-exposed to low doses and subsequently to high doses. The results might suggest that there is no a simple link between repair of DNA DSB and the induction of adaptive response which is found in chromosomal aberration.
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Книги з теми "DNA strand":

1

Mills, Kevin D. Silencing, heterochromatin, and DNA double strand break repair. Boston: Kluwer Academic Publishers, 2001.

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2

Mills, Kevin D. Silencing, Heterochromatin and DNA Double Strand Break Repair. Boston, MA: Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-4361-9.

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3

Al-Zain, Amr M. Mutagenic Repair Outcomes of DNA Double-Strand Breaks. [New York, N.Y.?]: [publisher not identified], 2021.

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4

Caroll, Robin. Strand of deception. Nashville, Tenn: B & H Books, 2013.

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5

Schrank, Benjamin Robin. Nuclear Arp2/3 drives DNA double-strand break clustering for homology-directed repair. [New York, N.Y.?]: [publisher not identified], 2019.

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6

Lee, So Jung. Mre11-Rad50-Xrs2 Complex in Coordinated Repair of DNA Double-Strand Break Ends from I-SceI, TALEN, and CRISPR-Cas9. [New York, N.Y.?]: [publisher not identified], 2022.

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7

Vranješ, Đorđe. Sa obe strane dana. Sremska Mitrovica: Književna zajednica, 1997.

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8

Sinsheimer, Robert. The strands of a life: The science of DNA and the art of education. Berkeley: University of California Press, 1994.

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9

Keim, Celia D. Post Translational Regulation of AID Targeting to Both Strands of a Transcribed DNA Substrate. [New York, N.Y.?]: [publisher not identified], 2012.

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10

Affaitati, Marco. Dia logos: Lungo le strade della bellezza. Roma: Artemide, 2012.

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Частини книг з теми "DNA strand":

1

Wang, Zhiyu, Yingxin Hu, Zhekun Chen, Sulin Liao, and Yabing Huang. "Performing DNA Strand Displacement with DNA Polymerase." In Communications in Computer and Information Science, 198–208. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-3415-7_16.

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2

Olive, P. L. "Discussion: Cellular DNA Strand Breakage." In The Early Effects of Radiation on DNA, 107–10. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-75148-6_11.

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3

Cardelli, Luca. "Strand Algebras for DNA Computing." In Lecture Notes in Computer Science, 12–24. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-10604-0_2.

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4

Thachuk, Chris, Erik Winfree, and David Soloveichik. "Leakless DNA Strand Displacement Systems." In Lecture Notes in Computer Science, 133–53. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-21999-8_9.

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5

Gloor, Gregory B., Tammy Dray, and Kathy Keeler. "Analyzing Double-Strand Repair Events in Drosophila." In DNA Repair Protocols, 425–38. Totowa, NJ: Humana Press, 1999. http://dx.doi.org/10.1007/978-1-4612-1608-7_34.

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6

Falk, Martin, Emilie Lukasova, and Stanislav Kozubek. "Repair of DNA Double-Strand Breaks." In Radiation Damage in Biomolecular Systems, 329–57. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-2564-5_20.

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7

Liang, Feng, and Maria Jasin. "Extrachromosomal Assay for DNA Double-Strand Break Repair." In DNA Repair Protocols, 487–97. Totowa, NJ: Humana Press, 1999. http://dx.doi.org/10.1007/978-1-4612-1608-7_40.

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8

Kameda, Atsushi, Masahito Yamamoto, Hiroki Uejima, Masami Hagiya, Kensaku Sakamoto, and Azuma Ohuchi. "Conformational Addressing Using the Hairpin Structure of Single-Strand DNA." In DNA Computing, 219–24. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-24628-2_22.

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9

Lindahl, Tomas, Masahiko S. Satoh, and Grigory Dianov. "Enzymes acting at strand interruptions in DNA." In DNA Repair and Recombination, 53–58. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0537-8_8.

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10

Tang, Weiyang, Weiye Zhong, Yun Tan, Guan A. Wang, Feng Li, and Yizhen Liu. "DNA strand displacement reaction: a powerful tool for discriminating single nucleotide variants." In DNA Nanotechnology, 377–406. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-54806-3_12.

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Тези доповідей конференцій з теми "DNA strand":

1

Mindek, Peter, Tobias Klein, and Alfredo De Biasio. "DNA replication of the lagging strand." In SIGGRAPH '23 Electronic Theater: Special Interest Group on Computer Graphics and Interactive Techniques Conference: Electronic Theater. New York, NY, USA: ACM, 2023. http://dx.doi.org/10.1145/3577024.3588981.

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2

Xie, Wenzhang, Junli Li, Chunyan Li, Rui Qiu, Congchong Yan, and Zhi Zeng. "Comparison of DNA strand-break simulated with different DNA models." In SNA + MC 2013 - Joint International Conference on Supercomputing in Nuclear Applications + Monte Carlo, edited by D. Caruge, C. Calvin, C. M. Diop, F. Malvagi, and J. C. Trama. Les Ulis, France: EDP Sciences, 2014. http://dx.doi.org/10.1051/snamc/201405126.

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3

Zheng, Xuedong, and Yang Ru. "Autonomous DNA Neuron Learning Algorithm Based on DNA Strand Displacement." In BIC 2022: 2022 2nd International Conference on Bioinformatics and Intelligent Computing. New York, NY, USA: ACM, 2022. http://dx.doi.org/10.1145/3523286.3524540.

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4

Shi, Lanlan, Changjun Zhou, and Qiang Zhang. "The neuronal perceptron with DNA strand displacement." In 2018 Tenth International Conference on Advanced Computational Intelligence (ICACI ). IEEE, 2018. http://dx.doi.org/10.1109/icaci.2018.8377534.

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5

Spencer, Frankie, Usman Sanwal, and Eugen Czeizler. "Distributed Simulations of DNA Multi-strand Dynamics." In 12th International Conference on Simulation and Modeling Methodologies, Technologies and Applications. SCITEPRESS - Science and Technology Publications, 2022. http://dx.doi.org/10.5220/0011266400003274.

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6

Hossain, Roksana, Robinson Mittmann, Ebrahim Ghafar-Zadeh, Geoffery G. Messier, and Sebastian Magierowski. "GPU base calling for DNA strand sequencing." In 2017 IEEE 60th International Midwest Symposium on Circuits and Systems (MWSCAS). IEEE, 2017. http://dx.doi.org/10.1109/mwscas.2017.8052869.

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7

Adi, Wibowo, and Kosuke Sekiyama. "One double-stranded DNA probes as classifier of multi targeting strand." In 2014 International Symposium on Micro-NanoMechatronics and Human Science (MHS). IEEE, 2014. http://dx.doi.org/10.1109/mhs.2014.7006166.

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8

Shi, Lanlan, Changjun Zhou, and Qiang Zhang. "Four digits BCD adder with DNA strand displacement." In 2017 4th International Conference on Systems and Informatics (ICSAI). IEEE, 2017. http://dx.doi.org/10.1109/icsai.2017.8248555.

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9

Akbay, Nuriye, Krishanu Ray, Mustafa H. Chowdhury, and Joseph R. Lakowicz. "Plasmon-controlled fluorescence and single DNA strand sequenching." In SPIE BiOS, edited by Tuan Vo-Dinh and Joseph R. Lakowicz. SPIE, 2012. http://dx.doi.org/10.1117/12.916177.

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10

Palego, C., J. C. M. Hwang, C. Merla, F. Apollonio, and M. Liberti. "Nanopore test circuit for single-strand DNA sequencing." In 2012 IEEE Topical Meeting on Silicon Monolithic Integrated Circuits in Rf Systems (SiRF). IEEE, 2012. http://dx.doi.org/10.1109/sirf.2012.6160154.

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Звіти організацій з теми "DNA strand":

1

Chen, Phang-Lang. BRCA2 and the DNA Double-Strand Break Repair Machinery. Fort Belvoir, VA: Defense Technical Information Center, October 2000. http://dx.doi.org/10.21236/ada392755.

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2

Abratt, V., J. Santangelo, D. Woods, M. Peak, and J. Peak. Induction and repair of DNA strand-breaks in Bacteroides fragilis. Office of Scientific and Technical Information (OSTI), January 1989. http://dx.doi.org/10.2172/5365674.

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3

Beal, P. A., and P. B. Dervan. Recognition of Double Helical DNA by Alternate Strand Triple Helix Formation. Fort Belvoir, VA: Defense Technical Information Center, June 1992. http://dx.doi.org/10.21236/ada251499.

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4

Anderson, Carl W., and Mangala Tawde. Differential Expression of DNA Double-Strand Break Repair Proteins in Breast Cells. Fort Belvoir, VA: Defense Technical Information Center, July 2001. http://dx.doi.org/10.21236/ada396787.

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5

Anderson, Carl W., and Mangale Tawde. Differential Expression of DNA Double-Strand Break Repair Proteins in Breast Cells. Fort Belvoir, VA: Defense Technical Information Center, July 2002. http://dx.doi.org/10.21236/ada408738.

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6

Anderson, Carl W. Differential Expression of DNA Double-Strand Break Repair Proteins in Breast Cells. Fort Belvoir, VA: Defense Technical Information Center, July 2003. http://dx.doi.org/10.21236/ada419972.

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7

Chen, D. J., and R. B. Cary. Identification and Characterization of a Human DNA Double-Strand Break Repair Complex. Office of Scientific and Technical Information (OSTI), July 1999. http://dx.doi.org/10.2172/759194.

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8

Deininger, Prescott L. The Human L1 Element Causes DNA Double-Strand Breaks in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, August 2006. http://dx.doi.org/10.21236/ada474882.

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9

Dickman, Rebekah. Thermodynamic Effects of 5' and 3' Single Strand Dangling Ends on Short Duplex DNA. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.94.

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10

Hosselet, S. The effect of radiation penetration on DNA single-strand breaks in rat skin explants. Office of Scientific and Technical Information (OSTI), January 1989. http://dx.doi.org/10.2172/5561134.

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