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Добірка наукової літератури з теми "Diagnostic agent"

Автор: Grafiati

Опубліковано: 11 березня 2023

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Статті в журналах з теми "Diagnostic agent"

YOKOSUKA, Masahiro, and Kei TAKEBAYASHI. "Diagnostic Agent." Journal of the Japan Society of Colour Material 72, no. 2 (1999): 115–23. http://dx.doi.org/10.4011/shikizai1937.72.115.

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&NA;. "Diagnostic agent pulled from market." Nursing 36, no. 2 (February 2006): 30. http://dx.doi.org/10.1097/00152193-200602000-00022.

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Hamdi, Abdullah, Matthias Mueller, and Bernard Ghanem. "SADA: Semantic Adversarial Diagnostic Attacks for Autonomous Applications." Proceedings of the AAAI Conference on Artificial Intelligence 34, no. 07 (April 3, 2020): 10901–8. http://dx.doi.org/10.1609/aaai.v34i07.6722.

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One major factor impeding more widespread adoption of deep neural networks (DNNs) is their lack of robustness, which is essential for safety-critical applications such as autonomous driving. This has motivated much recent work on adversarial attacks for DNNs, which mostly focus on pixel-level perturbations void of semantic meaning. In contrast, we present a general framework for adversarial attacks on trained agents, which covers semantic perturbations to the environment of the agent performing the task as well as pixel-level attacks. To do this, we re-frame the adversarial attack problem as learning a distribution of parameters that always fools the agent. In the semantic case, our proposed adversary (denoted as BBGAN) is trained to sample parameters that describe the environment with which the black-box agent interacts, such that the agent performs its dedicated task poorly in this environment. We apply BBGAN on three different tasks, primarily targeting aspects of autonomous navigation: object detection, self-driving, and autonomous UAV racing. On these tasks, BBGAN can generate failure cases that consistently fool a trained agent.

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Tsolekile, Ncediwe, Simphiwe Nelana, and Oluwatobi Samuel Oluwafemi. "Porphyrin as Diagnostic and Therapeutic Agent." Molecules 24, no. 14 (July 23, 2019): 2669. http://dx.doi.org/10.3390/molecules24142669.

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The synthesis and application of porphyrins has seen a huge shift towards research in porphyrin bio-molecular based systems in the past decade. The preferential localization of porphyrins in tumors, as well as their ability to generate reactive singlet oxygen and low dark toxicities has resulted in their use in therapeutic applications such as photodynamic therapy. However, their inherent lack of bio-distribution due to water insolubility has shifted research into porphyrin-nanomaterial conjugated systems to address this challenge. This has broadened their bio-applications, viz. bio-sensors, fluorescence tracking, in vivo magnetic resonance imaging (MRI), and positron emission tomography (PET)/CT imaging to photo-immuno-therapy just to highlight a few. This paper reviews the unique theranostic role of porphyrins in disease diagnosis and therapy. The review highlights porphyrin conjugated systems and their applications. The review ends by bringing current challenges and future perspectives of porphyrin based conjugated systems and their respective applications into light.

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&NA;. "Diagnostic agent tested for anticancer effect." Inpharma Weekly &NA;, no. 932 (April 1994): 11. http://dx.doi.org/10.2165/00128413-199409320-00025.

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Ekladious, Adel, Luke P. Wheeler, and Mai Yamanaka. "Gastrografin: a diagnostic and therapeutic agent." Internal Medicine Journal 48, no. 12 (December 2018): 1547–49. http://dx.doi.org/10.1111/imj.14125.

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Attique, Isma, Shabbir Hussain, Muhammad Amjad, Khalida Nazir, and Muhammad Shahid Nazir. "The Therapeutic and Diagnostic Value of Fluorine." Scientific Inquiry and Review 4, no. 1 (March 2020): 17–29. http://dx.doi.org/10.32350/sir.41.02.

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Fluorine has a useful positron transmitting isotope and it enjoys broad application in the medical field. It is utilized in fluorinated agents,therapeutic sciences and steroid field. Fluorine incorporation viafluoroalkylation is a useful approach in the development of new functional materials and in drug design. Fluorine also plays its role as an anticancer agent and is a successful chemotherapeutic agent for certain sorts of malignant growth. 5-fluorouracil plays a vital role in the treatment of cancer. 18 Facts as a radio label tracer atom in PET imaging. 19 F has the second most sensitive and stable NMR-active nucleus.

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Dowdeswell, Barry, Roopak Sinha, and Stephen G. MacDonell. "Architecting an Agent-Based Fault Diagnosis Engine for IEC 61499 Industrial Cyber-Physical Systems." Future Internet 13, no. 8 (July 23, 2021): 190. http://dx.doi.org/10.3390/fi13080190.

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IEC 61499 is a reference architecture for constructing Industrial Cyber-Physical Systems (ICPS). However, current function block development environments only provide limited fault-finding capabilities. There is a need for comprehensive diagnostic tools that help engineers identify faults, both during development and after deployment. This article presents the software architecture for an agent-based fault diagnostic engine that equips agents with domain-knowledge of IEC 61499. The engine encourages a Model-Driven Development with Diagnostics methodology where agents work alongside engineers during iterative cycles of design, development, diagnosis and refinement. Attribute-Driven Design (ADD) was used to propose the architecture to capture fault telemetry directly from the ICPS. A Views and Beyond Software Architecture Document presents the architecture. The Architecturally-Significant Requirement (ASRs) were used to design the views while an Architectural Trade-off Analysis Method (ATAM) evaluated critical parts of the architecture. The agents locate faults during both early-stage development and later provide long-term fault management. The architecture introduces dynamic, low-latency software-in-loop Diagnostic Points (DPs) that operate under the control of an agent to capture fault telemetry. Using sound architectural design approaches and documentation methods, coupled with rigorous evaluation and prototyping, the article demonstrates how quality attributes, risks and architectural trade-offs were identified and mitigated early before the construction of the engine commenced.

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Kang, Hyo-Jin, Jae Young Lee, and Jeong Min Lee. "The Principle of Contrast-enhanced Ultrasound and the Diagnosis of Hepatocellular Carcinoma." Korean Journal of Abdominal Radiology 6, no. 1 (July 15, 2022): 12–21. http://dx.doi.org/10.52668/kjar.2022.00129.

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Contrast-enhanced ultrasound (CEUS) is a specialized ultrasound performed with microbubble contrast agents. It is valuable for characterizing hepatic lesions without renal toxicity or radiation hazard. This review provides up-to-date practical knowledge of CEUS to make the interpretation of CEUS more accurate and clinically relevant. It includes the principle of CEUS, comparison of two kinds of contrast agents (the pure blood-pool agent and the Kupffer agent), diagnostic criteria for hepatocellular carcinoma, and its role in the diagnostic algorithms.

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Thompson, Cheryl A. "New diagnostic agent approved for lymphatic mapping." American Journal of Health-System Pharmacy 70, no. 8 (April 15, 2013): 648. http://dx.doi.org/10.2146/news130027.

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Дисертації з теми "Diagnostic agent"

Rokka, Johan. "Agent-Based Argumentative Diagnostic Reasoning in Dementia." Thesis, Umeå universitet, Institutionen för datavetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-52092.

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This thesis describes the development of a source-based argumentation dialogue system in the medical domain of dementia. Its aim is to enable a physician and a computer agent to establish the presence or absence of a dementia condition or diagnoses for a specific patient. The participants take turn in making the moves in a dialogue, every move consists of an argument or a critical question (a challenge) and during the process of arguments and counterarguments an argumentation-tree, in which a winner may be declared, is constructed.The following four particular problems are formulated and solved: 1. how could an appropriate argumentation graph be designed enabling a dementia debate; 2. how could an algorithm automatically select attacks in the argumentation graph on behalf of the computer agent using ACKTUS, a semantic web-application for modeling knowledge (1); 3a. how could the reasoning in an argumentation graph be improved by using inquiry dialogues introduced by Black & Hunter (2) to ensure a correct winner election; 3b how could it handle the mutual attack problem, and 4. how could the solutions for these issues be implemented?Through a literature study, ACKTUS review, discussions with expertise and a trial and error approach, solutions to the above problems were suggested. The design of schemes, critical questions and their relation was constructed following a source-based approach. An attack algorithm using a ranking- and a selection procedure was invented where the selection was based on likelihood of winning, degree of user-friendliness, profit, essentiality in the discussion and user preferences. A defeasible logic adapted by Black & Hunter was introduced for the arguments in the designed argumentation graph. After applying special techniques, Black & Hunter’s inquiry dialogue system were used to create dynamic arguments in a new argumentation tree, which enabled a comparison with the designed argumentation tree. This ensured the correctness of the winner election in that argumentation tree. Also an ignorance concept, where the latest attack always is considered a winner, was used to deal with the mutual attack problem. A web-based implementation of the system was accomplished.The results were evaluated regarding functionality. However, a presentation of the system to physicians with further evaluation, still remains. Limitations of the system are that it uses a subset of ACKTUS content that does not include the handling of conflicting arguments, and the mutual attack problem is limited. These issues are all subjects for further development and improvement. Another future prospect is an introduction of Artificial Intelligence algorithm/s such as CBR (Case Base Reasoning) which might improve the system’s performance.One conclusion was that even more refinements were needed before using the system in health care. Another conclusion was that the work had shown how a system for dementia could be developed using an argumentation dialogue between a computer agent and a human participant with an algorithm for automatically attacks and an improvement of reasoning ensuring the accuracy of the winner election.

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Haigh, Julian Saunders. "Investigation in to the Effect of Spin Locking on Contrast Agent Relaxivity." PDXScholar, 2015. http://pdxscholar.library.pdx.edu/open_access_etds/2496.

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The current trend in magnetic resonance imaging (MRI) is towards higher external magnetic field strengths (B0) to take advantage of increased sensitivity and signal to noise ratio (SNR). Unfortunately, as (B0) increases the effectiveness (relaxivity) of clinical gadolinium (Gd3+)-based contrast agents (CAs) administered to enhance image contrast is significantly reduced. Excellent soft tissue contrast can be generated with current agents despite their non-optimum relaxivities but necessitates large doses. The limits of detection of a CA at high B0 fields can be lowered by recovering the lost relaxivity and is a pre-requisite to the goal of molecular imaging in which CAs are bound to biomarkers of pathology that exist at very low concentrations. Traditional methods for increasing the detectability of CAs have focused on optimizing critical parameters identified from the Solomon-Bloembergen-Morgan (SBM) theory that affect relaxivity. Gains in relaxivity with these methods to date have been modest and are far from the theoretical maximum possible. Although researchers continue to investigate novel complexes that provide improved relaxivities, any such complex would require a lengthy and costly approval process with the U.S. Food and Drug Administration (FDA). Therefore, a method that affords improved relaxivities of current clinically approved CAs, particularly at high B0 fields, that could be adopted into clinical practice rapidly, is of great interest. Spin locking is a nuclear magnetic resonance (NMR) technique that was introduced for imaging in 1985, but has received very little attention in combination with Gd3+-based CAs. The technique employs a low power long duration radiofrequency (RF) pulse (B1) parallel to the net magnetization in the x,y-plane. This locks the magnetization into lower precessional frequencies around an "effective" field (Beff) that is reduced with respect to B0 but maintains the high field advantages required for imaging. When considered in the rotating frame, longitudinal relaxation of the magnetization against Beff exhibits shorter time constants (T1p) expected at these lower precessional frequencies. This leads to higher relaxivities, which has implications for increasing CA detectability. The experiments described herein show that rotating frame longitudinal relaxivities (r1p) for current clinical Gd3+-based CAs are essentially independent of the strength of the spin lock pulse (yB1) as predicted by theory. This result is important because it allows the value of yB1 to be neglected when comparing r1p of Gd3+-based CAs across several B0 fields. The magnetic field dependence of r1p for all clinical agents showed that relaxivity, lost by moving to higher fields, could be "recovered" and that r1p was sensitive to the rotational correlation time constant (TR) of the agent. Using high molecular weight Nanoassembled capsules (NACs) containing a Gd3+-based CA to probe this finding further, we were able to generate relaxivities at high field up to an order of magnitude greater than clinical agents at current imaging fields. These are beyond anything previously reported, or likely to be, with current techniques. Finally, we demonstrated that by spin locking Mn2+ agents, relaxivities at high field increased by a factor of ~ 30 than without spin locking, due to their larger dependence on scalar coupling. These findings show the potential of spin locking to increase detection limits dramatically at high field and are an exciting development towards the goal of molecular imaging.

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Kandanapitiye, Murthi S. "Synthesis of Biocompatible Nanoparticulate Coordination Polymers for Diagnostic and Therapeutic Applications." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1429019837.

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Dumont, Julien. "Systèmes multi-agent pour le diagnostic pluri-disciplinaire." Phd thesis, Ecole Nationale Supérieure des Mines de Saint-Etienne, 2011. http://tel.archives-ouvertes.fr/tel-00844133.

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Ce travail de recherche est consacré à la formalisation et à la réalisation d'un processus de diagnostic pluridisplinaire. La particularité d'un tel diagnostic résulte du fait qu'il nécessite de nombreux spécialistes, chacun ayant des connaissances sur leur domaine. Le problème principal réside dans les interconnexions entre les domaines. Ces interconnexions peuvent ou non être connues et influer sur le diagnostic. Dans ce manuscrit, nous proposons de réaliser un diagnostic pluridisciplinaire l'aide d'un système multi-agents. Les agents élaborent un diagnostic local à un domaine puis, fusionnent leurs diagnostics afin d'obtenir le diagnostic pluridisciplinaire. Dans ce but, nous proposons un cadre d'argumentation et une méthode de fusion des diagnostics. Ensemble, ces deux propositions forment le modèle ANDi.

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COSTA, ANDREW DINIZ DA. "A HYBRID DIAGNOSTIC-RECOMMENDATION APPROACH FOR MULTI-AGENT SYSTEMS." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2008. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13383@1.

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CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO
Sistemas multi-agentes são sociedades com agentes autônomos e heterogêneos que podem trabalhar em conjunto para alcançar objetivos similares ou totalmente diferentes. Quando falhas acontecem enquanto algum agente de software tenta alcançar seus objetivos, torna-se importante entender porque tais falhas acontecem e o que pode ser feito para remediar tais problemas. Considerando o ambiente distribuído, dinâmico e a natureza dos sistemas multi-agentes, é importante definir os requisitos necessários para realizar diagnósticos das falhas e recomendações de planos alternativos para agentes que desejam alcançar seus objetivos. Assim, esta dissertação propõe soluções para os principais desafios de criar um sistema que realize diagnósticos e proveja recomendações sobre execuções de agentes. Além disso, o trabalho propõe um framework híbrido de diagnóstico e recomendação que provê suporte para tais desafios. A partir do framework, instâncias de diferentes domínios podem ser criadas, como, por exemplo, aplicações baseadas em computação ubíqua e diferentes diagnósticos e recomendações podem ser providas.
Multi-agent systems are societies with autonomous and heterogeneous agents that can work together to achieve similar or different goals. Agents executing in such systems may not be able to achieve their goals due to failures during system execution. When an agent tries to achieve its desired goals, but faces failures during execution, it becomes important to understand why such failures occurred and what can be done to remedy the problem. The distributed, dynamic and nature of multi-agent systems calls for a new form of failure handling approach to address its unique requirements, which involves both diagnosing specific failures and recommending alternative plans for successful agent execution and goal attainment. We discuss solutions to the main challenges of creating a system that can perform diagnoses and provide recommendations about agent executions to support goal attainment, and propose a hybrid diagnostic-recommendation framework that provides support for methods to address such challenges. From the framework, instances of different domains can be created, such as, applications based on ubiquitous computing and different diagnoses and recommendations can be provided.

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Touaf, Samir. "Diagnostic logique des systèmes complexes dynamiques dans un contexte multi-agent." Université Joseph Fourier (Grenoble), 2005. http://www.theses.fr/2005GRE10038.

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Cette thèse propose une méthodologie pour la conception de systèmes de diagnostic fiables permettant d'appréhender les systèmes dynamiques complexes et spatialement distribués. Les résultats proposés s'appuient d'une part sur des techniques d'analyse diagnostic formelle ou à base de consistance, qui permettent de garantir la justesse de l'analyse diagnostic, et d'autre part, sur le paradigme multiagents. Les algorithmes proposés permettent de déduire tous les défauts possibles pour un comportement observé en les classant suivant différents critères de vraisemblance. Notre contribution a consisté à proposer une méthode de diagnostic qui tire partie des deux approches DX (communauté d'Intelligence Artificielle) et FOI (communauté Automatique) en distinguant la phase de détection, qui peut se faire à base de techniques variées et parfois très sophistiquées (observateur d'état, relation de parité, traitement de signal,. . . ), de la phase de localisation ou d'analyse diagnostic, qui doit permettre de garantir ce qui peut l'être et d'analyser toutes les informations disponibles pour en déduire le diagnostic le plus juste et complet possible. De plus, nous avons montré qu'il était possible d'appréhender des incertitudes de décision en transposant la logique de l'analyse diagnostic en logique floue. Le travail présenté dans ce mémoire a été développé dans le cadre du projet européen MAGIC (Multi-Agents-Based Diagnostic Data Acquisition and Management in Complex systems). Les résultats sont en cours de transfert vers différentes industries grâce aux partenaires industriels du projet : les entreprises SATE (System Advanced Technologies Engineering) et SMS-DEMAG
This thesis proposes a methodology to design a reliable diagnosis systems permitting to comprehend the dynamic complex and spatially distributed systems. The proposed results lean on the, one hand, techniques of formai analysis diagnosis or to basis of consistency, that permits to guarantee the exactness of the diagnosis analysis, and on the other hand, on multi-agents paradigm. The proposed algorithms permit to deduct ail possible faults for an observed behavior while classifying them according to different criteria of plausibility. Our contribution consisted in proposing a method of diagnosis that pulls left of the two DX approaches (Artificial intelligence community) and FOI (Control community) while distinguishing the phase of detection, that can be done by various and sometimes very sophisticated techniques (state observer, parity relation, signal based,. . . ), of the phase of localization or diagnostic analysis, that must permit to guarantee what can be, and to analyze ail available information to deduct the just diagnosis and possible suit of i1. Besides, we showed that it was possible to fear uncertainties of decision while transposing the logic of the analysis diagnosis in fuzzy logic. Work presented in this memory has been developed in the setting of the European project called MAGIC (Multi-Agents-Based Diagnostic Data Acquisition and Management in Complex systems). Results are under transfer toward different industries thanks to the industrial partners of the project : the SATE enterprises (System Advanced Technologies Engineering) and SMS-DEMAG

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Hughes-Riley, Theodore. "Development and application of hyperpolarized krypton-83 as a new MRI contrast agent." Thesis, University of Nottingham, 2014. http://eprints.nottingham.ac.uk/14460/.

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Hyperpolarized (hp) gases such 129Xe and 83Kr (spin I = 1/2 and I = 9/2 respectively) can allow for significantly enhanced signal in a number of magnetic resonance applications. As a result there has been a growing interest in recent years to advance hp noble gas technology to non-invasively image the airspace of lungs, with the goal of developing a helpful probe for lung pathologies. 83Kr longitudinal relaxation (T1) has been shown to be sensitive to various surface properties, and may prove to be an interesting for identifying certain diseases including those that change surface chemistry (such as cystic fibrosis) or the surface-to-volume ratio in the lung (like in emphysema). This thesis contains several studies furthering 83Kr lung imaging, while also exploring methods for 129Xe imaging. A major focus has been on increasing spin polarization of the noble gases, as an increased polarization yields a greater MR signal strength. A novel low-pressure spin-exchange optical pumping technique has been utilized in this work allowing for 83Kr polarizations exceeding 17.5 %; as opposed to 4.4 % previously reported in literature. Gas produced in this fashion must be pressurized to above ambient before it is possible for it to be delivered to a lung. Two methodologies for pressurizing the noble gas via compression are explored and optimized for hp gas delivery to excised lungs with 83Kr polarizations as high as 13.8 % achievable after compression. This ultimately allowed for the first ever coronal 83Kr lung images in an ex vivo lung model. Further work repeated with isotopically enriched 83Kr achieved a surface-sensitive T1 relaxation map in this system. Finally gas handling techniques where created to allow for efficient and thorough mixing of the hp noble gases and O2 while minimizing relaxation effects. This is vital for any future in vivo studies.

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Kumar, Akhauri Prakash. "Agent based diagnostic system for the defect analysis during chemical mechanical polishing (CMP)." Heimsheim Jost-Jetter, 2005. http://deposit.d-nb.de/cgi-bin/dokserv?idn=976561247.

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Bryson, Joshua Matthew. "The Design and Study of Lanthanide-Chelating Macromolecular Diagnostic and Delivery Agents." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/28726.

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Macromolecular magnetic resonance imaging (MRI) contrast agents have unique localization and contrast enhancement properties. We have designed and studied a monodisperse paramagnetic β-cyclodextrin click cluster (Gd10) decorated with Gd-containing arms and unique contrast enhancing polymers. To synthesize Gd10, a novel alkyne-functionalized diethylenetriaminetetraacetic acid chelate was created and coupled to a per-azido-β-cyclodextrin core and chelated with Gd(III) to yield the precursor macromolecule. Luminescence measurements were carried out using an analogous structure Eu(III)-containing structure and indicated that each lanthanide has an average of 1.8 water exchange sites. Gd10 yields a high relaxivity profile (6.2 mM⁻¹ s⁻¹ per Gd(III) at 9.4 T). Gd10 shows toxicity higher than clinically used contrast agents such as Magnevist&trade in vitro in cardiomyoblast cells. No acute toxicity was observed in the rats (n = 9) and contrast enhanced image analysis indicates renal processes may be involved in clearance. The contrast enhancing polymers we developed are new macromolecular beacons that allow the delivery of nucleic acids to be visualized at different biological scales. They contain repeated oligoethyleneamines, for binding and compacting nucleic acids into nanoparticles, and Gd(III)/Eu(III) chelates. The chelated lanthanides allow the visualization of the delivery vehicle via microscopy and via magnetic resonance imaging (MRI). We demonstrate that these new delivery beacons effectively bind plasmid DNA(pDNA) and protect their cargo nucleic acids from nuclease damage. The lanthanide-chelate materials have been found to efficiently deliver pDNA into cultured cells and do not exhibit toxicity. Micrographs of cultured cells exposed to the nanoparticle complexes formed with fluorescein-labeled pDNA and the europium-chelated polymers reveal effective intracellular imaging of the delivery process. MRI of bulk cells exposed to the complexes formulated with pDNA and the gadolinium-chelated structures show bright image contrast, allowing visualization of effective intracellular delivery on the tissue-scale. Because of their versatility as imaging probes, these delivery beacons posses remarkable potential for tracking and understanding nucleic acid transfer in vitro and have promise for in vivo imaging applications. In later studies the Ln-chelating polymers were co-polymerized with dimethylgalacterate which definitively increases luciferase gene expression (up 50x enhancement) and cellular uptake (up to 2x enhancement).
Ph. D.

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Travagin, Fabio. "Synthesis of new contrast agents for biomedical applications." Doctoral thesis, Università del Piemonte Orientale, 2021. http://hdl.handle.net/11579/127849.

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Several different metal complexes are currently used in diagnostics and therapy (MRI, PET, SPECT, OI, TAT etc.). For their preparation a chelating agent (CA) is mandatory to hold the metal ion, to reduce its toxicity and to target its activity. Polyaminocarboxylates and polyaminophosphonates represent the best choice of CAs for the preparation of metal complexes exploited as imaging probes. These scaffolds ensure high thermodynamic and kinetic stability of the corresponding metal complex. However, their preparation is not always straightforward. During this PhD the research work was focused on the following three main objectives: 1) A strategy for the 1,7-heterodiprotection of cyclen with orthogonal protecting groups have been realised. This protection method is based on the control of pH to implant two different and orthogonal protecting groups in the cyclen scaffold. 2) This protection method has been exploited to prepare two novel bifunctional chelating agents (BFCAs) bearing a phosphonic functionality (DO2AP(tBu)4 and DO3AP(tBu)4). These two novel BFCAs have been designed to prepare innovative and stable metal complexes conjugated with vectors such as antibodies, peptides, nucleotides etc. 3) Three innovative CAs have been prepared and characterised: - TRASUTA is a hexadentate mesocyclic chelating agent and a rigidified AAZTA-like ligand for the coordination of Ga(III). - Cb-tebpm is a cyclam-based chelating agent, designed to prepare stable complexes with gadolinium or in general with lanthanides. - HB-DO3A is an HP-DO3A homologue, optimised to be a strong Gd(III) chelator. HBDO3A has been investigated in its safety profile. In vitro data have shown that, if compared to clinically approved MRI CAs, HB-DO3A presents low affinity to collagen. This characteristic could confer HB-DO3A the advantage of a faster and complete clearance after administration to the patient, with less release of toxic Gd(III) and less side effects.

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Книги з теми "Diagnostic agent"

1937-, Goldberg Barry B., ed. Ultrasound contrast agents. London: M. Dunitz, 1997.

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Jovitas, Skucas, ed. Radiographic contrast agents. 2nd ed. Rockville, Md: Aspen Publishers, 1989.

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Hoff, Lars. Acoustic characterization of contrast agents for medical ultrasound imaging. Dordrecht: Kluwer Academic Publishers, 2001.

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Gielen, Marcel, and Edward R. T. Tiekink, eds. Metallotherapeutic Drugs and Metal-Based Diagnostic Agents. Chichester, UK: John Wiley & Sons, Ltd, 2005. http://dx.doi.org/10.1002/0470864052.

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Th, Balzer, Hamm Bernd Prof Dr, and Niendorf H. P, eds. Contrast agents in liver imaging. Dordrecht: Kluwer Academic, 1995.

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Steven, Specter, Bendinelli Mauro, and Friedman Herman 1931-, eds. Rapid detection of infectious agents. New York: Plenum Press, 1998.

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Schroeder, Michael. Autonomous, Model-Based Diagnosis Agents. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5739-5.

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Schroeder, Michael. Autonomous, Model-Based Diagnosis Agents. Boston, MA: Springer US, 1998.

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Autonomous, model-based diagnosis agents. Boston: Kluwer, 1998.

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McHugh, Timothy D. Tuberculosis: Laboratory diagnosis and treatment strategies. Oxfordshire: CAB International, 2013.

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Частини книг з теми "Diagnostic agent"

Schell, Jonathan. "Fluorescein, as Diagnostic Agent." In Encyclopedia of Ophthalmology, 1–3. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-35951-4_84-4.

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Schell, Jonathan. "Fluorescein, as Diagnostic Agent." In Encyclopedia of Ophthalmology, 766–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-540-69000-9_84.

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Gatton, Thomas M., Malrey Lee, TaeEun Kim, and Young-Keun Lee. "Diagnostic Knowledge Acquisition for Agent-Based Medical Applications." In Agent and Multi-Agent Systems: Technologies and Applications, 626–35. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-72830-6_65.

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Cristani, Matteo, Francesco Olivieri, Claudio Tomazzoli, and Margherita Zorzi. "Towards a Logical Framework for Diagnostic Reasoning." In Agents and Multi-Agent Systems: Technologies and Applications 2018, 144–55. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-92031-3_14.

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Serna, Bladimir, Rosario Baltazar, Miguel Casillas, Yesica Saavedra, Arnulfo Alanis, and Antonio Meza. "Medical Diagnostic Through a Mobile Application Controlled by Brain Waves: ConsultApp." In Agents and Multi-agent Systems: Technologies and Applications 2019, 185–93. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8679-4_16.

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Chao, Sam, and Fai Wong. "A Multi-Agent Learning Paradigm for Medical Data Mining Diagnostic Workbench." In Data Mining and Multi-agent Integration, 177–86. Boston, MA: Springer US, 2009. http://dx.doi.org/10.1007/978-1-4419-0522-2_12.

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Higdon, Jane V., and Emily Ho. "30Zn The Role of Zinc As a Metallotherapeutic Agent." In Metallotherapeutic Drugs and Metal-Based Diagnostic Agents, 237–57. Chichester, UK: John Wiley & Sons, Ltd, 2005. http://dx.doi.org/10.1002/0470864052.ch13.

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Famador, Sandra Mae W., and Tardi Tjahjadi. "DiaTTroD: A Logical Agent Diagnostic Test for Tropical Diseases." In Advances in Intelligent Systems and Computing, 97–115. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-52243-8_8.

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Watanabe, Yuji, Shigeyuki Sato, and Yoshiteru Ishida. "Mutual Repairing System Using Immunity-Based Diagnostic Mobile Agent." In Lecture Notes in Computer Science, 72–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/11552451_10.

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Garcia-Retuerta, David, Roberto Casado-Vara, and Sara Rodríguez. "Transfer Learning for Arthropodous Identification and its Use in the Transmitted Disease Diagnostic." In Highlights in Practical Applications of Agents, Multi-Agent Systems, and Social Good. The PAAMS Collection, 253–60. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-85710-3_21.

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Тези доповідей конференцій з теми "Diagnostic agent"

Rehemujiang, G. Tuerxun, Taxipulati, and Xiashadan. "Multi-agent diagnostic system and its application." In Proceedings of the Ninth International Conference on Computer Supported Cooperative Work in Design. IEEE, 2005. http://dx.doi.org/10.1109/cscwd.2005.194221.

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Buldakova, T. I., A. V. Lantsberg, and S. I. Suyatinov. "Multi-Agent Architecture for Medical Diagnostic Systems." In 2019 1st International Conference on Control Systems, Mathematical Modelling, Automation and Energy Efficiency (SUMMA). IEEE, 2019. http://dx.doi.org/10.1109/summa48161.2019.8947489.

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Godin, Patrice, and Chun Wang. "Agent-based outpatient scheduling for diagnostic services." In 2010 IEEE International Conference on Systems, Man and Cybernetics - SMC. IEEE, 2010. http://dx.doi.org/10.1109/icsmc.2010.5642281.

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"A HYBRID DIAGNOSTIC-RECOMMENDATION SYSTEM FOR AGENT EXECUTION IN MULTI-AGENT SYSTEMS." In 3rd International Conference on Software and Data Technologies. SciTePress - Science and and Technology Publications, 2008. http://dx.doi.org/10.5220/0001879401590168.

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Borsukov, A. V., S. B. Krukovskiy, L. N. Markelova, O. A. Gorbatenko, and D. Yu Venidiktova. "Contrast-enhanced ultrasound of kidneys in patients with type 2 diabetes and chronic pyelonephritis: a new dosage of the contrast-enhanced agent." In Наука России: Цели и задачи. НЦ "LJournal", 2021. http://dx.doi.org/10.18411/sr-10-04-2021-65.

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Objective. To evaluate the diagnostic efficacy of the contrast-enhanced ultrasound examination of kidneys in patients with chronic pyelonephritis with a dose of injected contrast agent – 1.0 ml. Materials and methods. In 2020, 20 patients with chronic pyelonephritis were examined on the basis of the Fundamental research laboratory “Diagnostic Researches and Minimally Invasive Technologies”, Smolensk State Medical University. All patients underwent ultrasound examination Doppler mapping mode of the kidneys and the. Also, all patients underwent contrast-enhanced ultrasound examination of the kidneys for the diagnosis of angionephrosclerosis. Results. Using the improved technique in patients of group 2 compared with patients in group 1, the quality of the images obtained was preserved. In patients of group 1 with chronic pyelonephritis, the quantitative indicators correspond to the initial manifestations of angionephrosclerosis. Conclusion. Thus, the improved CEUS technique with the use of 1.0 ml of contrast agent showed good possibilities in the diagnosis of angionephrosclerosis in patients with chronic pyelonephritis.

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Wang, Bo, and Liqun Liu. "Ontology-based multi-agent diagnostic system of enterprise management." In 2012 IEEE International Conference on Computer Science and Automation Engineering (CSAE). IEEE, 2012. http://dx.doi.org/10.1109/csae.2012.6272838.

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Matsumoto, Keinosuke, Tomoaki Maruo, and Akifumi Tanimoto. "A Dependable Multi-agent System with Self-Diagnostic Function." In 2009 Eighth International Symposium on Parallel and Distributed Computing (ISPDC). IEEE, 2009. http://dx.doi.org/10.1109/ispdc.2009.16.

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"MULTI AGENT-BASED ON-LINE DIAGNOSTIC SCHEME OF SUBSTATION IED." In 4th International Conference on Informatics in Control, Automation and Robotics. SciTePress - Science and and Technology Publications, 2007. http://dx.doi.org/10.5220/0001647202160219.

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Silva, Alzira F., Renata P. Barros, Samuel O. Azevedo, Akynara Silva, and Luiz M. G. Gonçalves. "Diagnostic Robotic Agent in the RoboEduc Environment for Educational Robotics." In 2008 IEEE Latin American Robotic Symposium (LARS). IEEE, 2008. http://dx.doi.org/10.1109/lars.2008.16.

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Nelius, Thomas. "5-aminolevulinic acid: from a diagnostic tool to a therapeutic agent." In International Symposium on Biomedical Optics, edited by Kenneth E. Bartels, Lawrence S. Bass, Werner T. de Riese, Kenton W. Gregory, Abraham Katzir, Nikiforos Kollias, Michael D. Lucroy, et al. SPIE, 2002. http://dx.doi.org/10.1117/12.430678.

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Звіти організацій з теми "Diagnostic agent"

McAvin, James C., and Joshua Bast. Leishmania Surveillance and Diagnostic Capability in Support of the Joint Biological Agent Identification and Diagnostic System (JBAIDS) and Leishmania Vector Surveillance. Fort Belvoir, VA: Defense Technical Information Center, February 2013. http://dx.doi.org/10.21236/ada573704.

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Swaby, James A., and James C. McAvin. Plasmodium Genus Assay Transition to the Joint Biological Agent Identification and Diagnostic System (JBAIDS). Fort Belvoir, VA: Defense Technical Information Center, July 2012. http://dx.doi.org/10.21236/ada564547.

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Swaby, James A., James C. McAvin, and Ratree Takhampunya. Test and Evaluation of Field-Deployable Infectious Disease Diagnostic Assays in Support of the Joint Biological Agent Identification and Diagnosis System (JBAIDS): Malaria (Plasmodium/JBAIDS). Fort Belvoir, VA: Defense Technical Information Center, May 2012. http://dx.doi.org/10.21236/ada562427.

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Pu, Fenglan, Tianli Li, Yingqiao Wang, Chunmei Tang, Chen Shen, and Jianping Liu. Cordyceps preparations for preventing contrast-induced nephropathy: A protocol of systematic review of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2022. http://dx.doi.org/10.37766/inplasy2022.6.0098.

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Review question / Objective: To systematically evaluate the efficacy and safety of cordyceps preparations as a complementary preventive therapy for Contrast-induced nephropathy (CIN). Condition being studied: At present, contrast agents are widely used in diagnostic and interventional radiology examinations worldwide. However, they can affect kidney function and cause a risk of renal impairment. Contrast-induced nephropathy (CIN) is defined as a rise in serum creatinine (SCr) levels by ≥ 25% of baseline or 44 µmol/l from the pre-contrast value within 72 h of intravascular administration of a contrast agent in the absence of an alternative etiology. The incidence of CIN varies widely among studies depending on study population and baseline risk factors, as for high-risk groups such as pre-existing renal insufficiency, diabetes, advanced age, or receiving nephrotoxic agents, the incidence is up to 30–50%. To date, CIN has been the third most common cause of hospital-acquired renal failure, after impaired renal perfusion and nephrotoxic medications, which can lead to longer hospital stay, increased costs and higher mortality.

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Bacharach, Eran, W. Ian Lipkin, and Avigdor Eldar. Identification of the etiological agent of tilapia disease in the Lake of Galillee. United States Department of Agriculture, January 2013. http://dx.doi.org/10.32747/2013.7597932.bard.

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Background to the topic. Tilapines serve as the second most important group of farmed fish worldwide. Massive mortality of wild and cultured tilapia has been observed recently in Israel but the pathogen of this disease has not been identified. We proposed to identify the agent responsible for disease.  Major conclusions, solutions, achievements. We characterized the lesions in diseased fish and found that the brain was one of the affected organs. We found conditions to isolate from brains of diseased fish the etiological agent of the tilapia disease and to propagate it in cell culture. This led to the identification of the pathogen as a novel RNA virus, which we named Tilapia Lake Virus (TiLV). Electron microscopy of TiLV revealed virion-like particles and ether/chloroform-sensitivity assays demonstrated that TiLV is enveloped. Low passage TiLV, injected intra-peritoneally to tilapia, induced a disease with over 80% mortality. Cohabitation of healthy with diseased fish demonstrated that the disease is contagious, and that mortalities occur within few days. Fish surviving initial mortality were immune to further TiLV infections, suggesting the mounting of protective immune response. Screening cDNA libraries and high throughput sequencing determined the sequence of TiLV genome. This demonstrated that TiLV is indeed a novel virus and allowed the design of a PCRbased diagnostic test.  Implications, both scientific and agricultural. The characterization of a novel, emerging RNA virus that imposes major threat to the tilapia industry, enables the specific identification of the virus in tilapines. This allows prompt screening and surveillance of TiLV, epidemiological studies, and disease containment. This also potentially opens the way for the development of vaccines against TiLV.

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Bercovier, Herve, and Paul Frelier. Pathogenic Streptococcus in Tilapia: Rapid Diagnosis, Epidemiology and Pathophysiology. United States Department of Agriculture, October 1994. http://dx.doi.org/10.32747/1994.7568776.bard.

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Within the project "Pathogenic Streptococcus in Tilapia", gram positive cocci pathogens of fish in Israel and in the United States were characterized. We showed that Streptococcus shiloi, the name for an agent causing septicemic infection in fish, is a junior synonym of Streptococcus iniae and that Enterococcus seriolicida is a junior synonym of Lactococcus garvieae, a causative agent of septicemia and meningo-encephalitis in fish. Molecular epidemiology studies on these two pathogens, based on 16S rDNA sequences and ribotyping showed that although each country had specific clones, S. iniae originated probably from the U.S. and L. garvieae from Japan. PCR assays were developed for both pathogens and applied to clinical samples. S. agalactiael S. difficile was also recognized for the first time in the U.S. in tilapia. Our histopathological studies explained the noted paradox (abundant in vitro growth often accompanied by scant to small numbers of organisms within the meninges in histologic sections of brain) in diagnostic of fish streptococcus. The greatest concentration of cocci were consistently observed within macrophages infiltrating the extrameningeal fibroadipose tissue surrounding the brain within the calvarium. These results also suggests that the primary route of meningeal infection may be extension from the extrameningeal connective tissue rather than meningeal vascular emigration of cocci-containing macrophages. Our work has resulted in a cognizance of streptococcus as fish pathogen which goes beyond the pathology observed in tilapia and is already extended to many aquaculture fish species in Israel and in the United States. Finally, our data suggest that vaccines (bivalent or trivalent) could be developed to prevent most of the damages caused by streptococcus in aquaculture.

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David, Allan E. Microenvironment-Sensitive Multimodal Contrast Agent for Prostate Cancer Diagnosis. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada610926.

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Benny, Paul. Diagnostic and Therapeutic Radiopharmaceutical Agents for Selective Discrimination of Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 2006. http://dx.doi.org/10.21236/ada484303.

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Davies, Imogen, Anam Parvez Butt, Thalia Kidder, and Ben Cislaghi. Social Norms Diagnostic Tool: Young Women's Economic Justice. Oxfam, December 2021. http://dx.doi.org/10.21201/2021.8427.

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The tool’s methodology is rooted in a feminist and youth-led participatory action research approach to diagnosing social norms. It uses participatory and transformative methods to engage young people and other community members not just as research participants, but as agents of change identifying solutions to arising issues. The exercises recognize and examine unequal power inequalities through questions around who makes key decisions, whose opinions matter the most, who the most influential people are and the nature of their influence. hese exercises were developed for Oxfam’s Empower Youth for Work (EYW) programme for primary research from 2017-2019. This version of the tool was originally developed for use in the EYW programme in Bangladesh.

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