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Добірка наукової літератури з теми "Diabetic retinopathy"

Автор: Grafiati
Опубліковано: 4 червня 2021
Оновлено: 29 липня 2024

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Статті в журналах з теми "Diabetic retinopathy"

1

Syuhada, Rahmat, Toni Prasetya, Ade Utia Detty, and Merryshol Okhi. "Visualoutcome Pada Pasien Retinopati Diabetik Pasca Operasi Pars Plana Vitrektomi Di Rumah Sakit Pertamina Bintang Amin Provinsi Lampung Tahun 2020/2021." MAHESA : Malahayati Health Student Journal 1, no. 4 (December 4, 2021): 394–403. http://dx.doi.org/10.33024/mahesa.v1i4.3958.

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ABSTRACT: VISUAL RESULTS OF DIABETES RETINOPATHY PATIENTS POST PARS PLANA VITRECTOMY OPERATION AT PERTAMINA BINTANG AMIN HOSPITAL Background: Diabetic retinopathy is a neovascular complication that is very specific for type 1 diabetes and type 2 diabetes. Based on data according to Basic Health Research (RISKESDAS) in 2018, diabetes mellitus in 2013 reached 1.5% of patients with diabetes, and is increasing. to 2.0% in 2018. Treatment of diabetes mellitus patients with complications of diabetic retinopathy by performing pars plana vitrectomy surgery which is anoperative management that can improve eye visual or restore visual fuction. Research Objectives: To determine the visual outcome in diabetic retinopathy patients after pars plana vitrectomy surgery at Pertamina Bintang Amin Hospital, Lampung Province in 2020.Research Methods: This type of research was cross -sectional. Sampling was done by total sampling. Bivariate data analysis using Paired T-Test.Results: Statistical analysis using Paired T-Test showed the p-value for visualoutcome analysis in diabetic retinopathy patients before and after pars plana vitrectomy surgery was 0.000 (p-value <0.05).Conclusions: There are significant changes in diabetic retinopathy patients visualoutcome before pars plana vitrectomy surgery and after pars plana vitrectomy surgery at Pertamina Hospital Amin Star Lampung Province 2020. Keywords: Diabetic retinopathy, pars plana vitrectomy operation, Visualoutcome INTISARI: VISUALOUTCOME PADA PASIEN RETINOPATI DIABETIK PASCA OPERASI PARS PLANA VITRECTOMY DI RUMAH SAKIT PERTAMINA BINTANG AMIN Latar Belakang: Retinopati diabetik adalah komplikasi neovaskular yang sangat spesifik untuk diabetes tipe 1 dan diabetes tipe 2. Berdasarkan data menurut Riset Kesehatan Dasar (RISKESDAS) pada tahun 2018, penyakit diabetes melitus di tahun 2013 mencapai 1,5% pasien pengidap diabetes, dan meningkat menjadi 2,0% pada tahun 2018. Penanganan pada pasien diabetes melitus dengan komplikasi retinopati diabetik diantaranya adalah dengan dilakukannya operasi pars plana vitrektomi yang merupakan penatalaksanaan operatif yang dapat memperbaiki visus mata atau memulihkan fungsi penglihatan . Tujuan Penelitian: Untuk mengetahui visualoutcome pada pasien retinopati diabetik pasca operasi pars plana vitrektomi di Rumah Sakit Pertamina Bintang Amin Provinsi Lampung Tahun 2020.Metode Penelitian: Jenis penelitian ini adalah potong silang (Cross-sectioal). Pengambilan sampel dilakukan secara total sampling. Analisis data bivariat dengan Paired T-Test.Hasil Penelitian: Analisis statistik menggunakan uji Paired T-Test menunjukkan p-value untuk analisa visualoutcome pada pasien retinopati diabetic sebelum dan sesudah operasi operasi pars plana vitrektomi sebesar 0,000 (p-value < 0,05).Kesimpulan: Terdapat perubahan yang signifikan pada visualoutcome pasien retinopati diabetik sebelum operasi pars plana vitrektomi dan sesudah operasi pars plana vitrektomi di Rumah Sakit Pertamina Bintang Amin Provinsi Lampung Tahun 2020. Kata Kunci: Retinopati Diabetik, Operasi Pars Plana Vitrektomi, Visualoutcome
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2

S. R. Ganorkar, P. N. Maldhure,. "Microaneurysms and Exudates Detection in Retinal Images using Deep Neural Network." Journal of Electrical Systems 20, no. 2s (March 31, 2024): 980–92. http://dx.doi.org/10.52783/jes.1745.

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Анотація:
One frequent diabetes consequence that affects the eyes is diabetic retinopathy(DR). The most frequent reasonfor blindness in working-age adults in the world is diabetic retinopathy. One in three diabetics has diabetic retinopathy to some extent. DR affects nearly all persons having type 1 diabetes and more than 60% of people having type 2 diabetes to some extent after 20 years of diabetes. In the US, approximately 4.2 million persons, 40 and older have diabetic retinopathy. In the United States, 12% of all new occurrences of blindness are caused by diabetic retinopathy.A 95% reduction in the risk of blindness is possible with a diabetic retinopathy early detection and treatment. The retina's appearance, the presence or absence of Microaneurysm and Exudates, and the degree of participation are all taken into account in the grading process. It has been demonstrated that deep neural networks (DNNs) work well for automatically grading diabetic retinopathy. The features like Microaneurysm and Exudates that are diagnostic of various stages of diabetic retinopathy are taught to these DNNs utilizing vast datasets of retinal pictures and accompanying grading information.It has been demonstrated that deep neural networks (DNNs) are efficient in automatically detecting diabetic retinopathy from retinal pictures. Sensitivity, specificity, precision, accuracy, and Kappa value are used to measure how well DNNs work in detecting diabetic retinopathy; these values are 95.74%, 92.31%, 96.77%, 94.74%, and 0.87, respectively.
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3

Simorangkir, Hans Andre Hamonangan. "Mikroenkapsulasi Kombinasi Curcumin pada Kunyit (Curcuma Longa) dan Epigallocatechin-3-Gallate (EGCG) pada Daun Teh Hijau (Camellia Sinensis): Inovasi Terapi Pencegahan Diabetik Retinopati pada Penderita Diabetes Melitus Tipe 2." SCRIPTA SCORE Scientific Medical Journal 1, no. 2 (February 1, 2020): 11. http://dx.doi.org/10.32734/scripta.v1i2.1234.

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ABSTRAK Retinopati diabetik adalah komplikasi mikrovaskular diabetes mellitus tipe 2 (DM Tipe 2) yang menjadi penyebab utama kebutaan pada orang dewasa. Penderita DM Tipe 2 berisiko 25 kali lebih mudah mengalami kebutaan dibanding nondiabetes. Minimnya pengetahuan pasien mengenai gejala, tidak adekuatnya pelayan kesehatan, dan masalah ekonomi merupakan faktor yang menyebabkan sulitnya penanganan retinopati diabetik. Kombinasi curcumin pada kunyit dan epigallocatechin-3-gallate (EGCC) pada daun teh hijau memiliki keunggulan sebagai terapi pencegahan diabetik retinopati. Curcumin adalah komponen utama kunyit, senyawa polifenol golongan flavonoid ini memiliki beragam khasiat sebagai antiinflamasi, antioxidant, antiangiogenik, dan antiproliferatif. EGCG merupakan komponen paling aktif yang ditemukan pada teh hijau dan memiliki efek antioxidant paling kuat. Senyawa aktif yang ada pada kedua tumbuhan tersebut memilki efek yang spesifik dalam mencegah terjadinya diabetik retinopati. Beberapa mekanisme berlangsung dalam tingkat sel sehingga efek yang diperoleh lebih efisien. Senyawa aktif curcumin dan EGCG merupakan senyawa alami yang berasal dari tanaman sehingga tidak akan menimbulkan efek samping pada dosis normal. Penggunaan metode mikroenkapsulasi dalam mengemas ekstak kunyit dan daun teh hijau akan membantu efektivitas kerja masing –masing zat aktif yang terkandung di dalam kedua tumbuhan tersebut. Zat aktif tersebut nantinya akan dikemas dalam bentuk butiran kecil yang penggunaannya dapat dikonsumsi langsung oleh penderita diabetes melitus tipe 2 sebagai terapi pencegahan diabetik retinopati. Kata Kunci: Curcumin, DM Tipe 2, EGCC, Mikroenkapsulasi, Retinopati Diabetik ABSTRACT Diabetic retinopathy is a microvascular complication of type 2 diabetes mellitus (DM type 2) which is a major cause of blindness in adults. Patients with Type 2 diabetes are 25 times more likely to replace blindness than non-diabetics. The lack of patient knowledge about the symptom, inadequate health services, and economic problems are factors that cause difficulties in handling diabetic retinopathy. The combination of curcumin in turmeric and epigallocatechin-3-gallate (EGCC) on green tea leaves has an advantage as a preventative therapy for diabetic retinopathy. Curcumin is the main component of turmeric, the polyphenol compound of the flavonoid group has a variety of properties as anti-inflammatory, antioxidant, antiangiogenic, and antiproliferative. EGCG is the most active component found in green tea leaves and has the strongest antioxidant effect. The active compounds in both plants have specific effects on the use of diabetic retinopathy. Some of the ongoing results at the cellular level produced are obtained more efficiently. The active compound curcumin and EGCG are natural compositions needed from plants so that they will not cause side effects at normal doses. The use of microencapsulation method in packaging turmeric extract and green leaves will help each of them - support the active substances contained in both plants. This active substance will be packaged in small granules that can be used directly by people with type 2 diabetes mellitus as a preventative therapy for diabetic retinopathy. Keywords: Curcumin, Diabetic Retinopathy, DM Type 2, EGCC, Microencapsulation.
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4

Tóth, Gábor, Zoltán Zsolt Nagy, and János Németh. "A cukorbetegség szemészeti szövődményeinek modellalapú költségterhe Magyarországon." Orvosi Hetilap 162, no. 8 (February 21, 2021): 298–305. http://dx.doi.org/10.1556/650.2021.32031.

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Анотація:
Összefoglaló. Bevezetés: A diabeteses retinopathia minden harmadik cukorbeteget érinti a világban, és a dolgozó korú lakosság körében a vakság vezető oka. Célkitűzés: Tanulmányunk célja a diabeteses retinopathia prevalenciaalapú költségterhének meghatározása 2018-ban a 18 évnél idősebb korú lakosság körében Magyarországon. Módszer: Standardizált ’rapid assessment of avoidable blindness’ (RAAB) + diabeteses retinopathia modul alapú metodikán alapuló modellel analizáltuk a diabeteses retinopathia költségterhét. A diabeteses retinopathia okozta gazdasági terhet a Nemzeti Egészségbiztosítási Alapkezelő és a páciensek oldaláról felmerülő költségeket analizálva vizsgáltuk. A prevalenciaalapú diabeteses retinopathia költségmodellt a skót diabeteses retinopathia klasszifikációnak és a diabeteses retinopathia súlyossági stádiumának megfelelően állítottuk össze. Eredmények: A diabeteses retinopathia költségterhe 43,66 milliárd Ft volt 2018-ban. A két fő költségviselő az anti-VEGF-injekciók (28,91 milliárd Ft) és a vitrectomiák (8,09 milliárd Ft) voltak. Ez a két kezelési mód volt felelős a diabeteses retinopathiával kapcsolatban felmerülő összes költség 84,7%-áért. Az egy páciensre jutó átlagos költségteher 54 691 Ft volt hazánkban. Következtetés: A cukorbetegek szemészeti járó- és fekvőbeteg-ellátása alulfinanszírozott hazánkban. A proliferatív diabeteses retinopathia és a diabeteses maculaoedema növekvő társadalmi-gazdasági terhe miatt érdemes volna javítani a megelőzés, a szűrés és a korai kezelés jelenlegi helyzetén. Orv Hetil. 2021; 162(8): 298–305. Summary. Introduction: Diabetic retinopathy affects every third people with diabetes mellitus in the world and is the leading cause of blindness in adults of working age. Objective: The aim of this study was to analyse the economic burden associated with diabetic retinopathy in people aged 18 years and older in Hungary. Method: Rapid assessment of avoidable blindness (RAAB) with the diabetic retinopathy module (DRM) based diabetic retinopathy cost model study was conducted in Hungary in 2018. Economic burden of diabetic retinopathy was analysed from the perspective of the National Health Insurance Fund system and the patients. Our prevalence-based diabetic retinopathy cost model was performed according to the Scottish diabetic retinopathy grading scale and based on the diabetic retinopathy severity stadium. Results: The total diabetic retinopathy-associated economic burden was 43.66 billion HUF in 2018. The two major cost drivers were anti-VEGF injections (28.91 billion HUF) and vitrectomies (8.09 billion HUF) in Hungary; they covered to 84.7% of the total cost among people with diabetes mellitus. The diabetic retinopathy-related cost per patient was 54 691 HUF in Hungary. Conclusion: Outpatient and inpatient eye care of people with diabetes mellitus are underfinanced in Hungary. Due to the increasing socio-economic burden of proliferative diabetic retinopathy and diabetic macular oedema, it would be important to invest in proliferative diabetic retinopathy and macular oedema prevention, screening and early treatment. Orv Hetil. 2021; 162(8): 298–305.
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5

Babu, Niya, Nima Teresa Andrew, Mercy Paul, Chakkalackal Varkey Anthrayose, Anchitha Meenu Rajeev, Rakendu Puthiyedath, Amitha Sunny, and Sreelakshmi K. T. Arun. "Diabetic Dermopathy (Shin Spots) and Diabetic Retinopathy - Are They Associated?" Journal of Evidence Based Medicine and Healthcare 7, no. 48 (November 30, 2020): 2806–10. http://dx.doi.org/10.18410/jebmh/2020/575.

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Анотація:
BACKGROUND Diabetes mellitus (DM) is a major cause of avoidable blindness in the developing and the developed countries. Diabetic patients have 25 times more chance of becoming blind than the non-diabetics.1 According to the WHO, the number of people in India affected with Diabetes Mellitus in the year 2000 was 31.7 million which is estimated to rise to 79.4 million by 2030, which would be higher than any other country in the world. 75 percent of all Type 2 diabetics and almost all Type 1 diabetics are expected to develop diabetic retinopathy (DR) over a period of time.2 Diabetic dermopathy or shin spots are the commonest dermatological manifestation in patients with Diabetes Mellitus. It is also known as pigmented pretibial patches, spotted leg syndrome or diabetic dermangiopathy.3 Both diabetic retinopathy and dermopathy are manifestations of diabetic microangiopathy. We wanted to study the association between diabetic retinopathy and diabetic dermopathy. METHODS 182 patients (between 40 - 70 years of age) having diabetes mellitus for at least five years were included in the study and were examined for retinal changes and skin changes. The study period was six months. RESULTS Of the 182 diabetic patients included in this study, 106 (58.2 %) had diabetic retinopathy. Shin spots were seen in 158 cases (86.8 %). 100 (94.3 %) cases with diabetic retinopathy had shin spots. The mean duration of diabetes mellitus in patients with diabetic retinopathy was 11.85 years and it was 8.16 years in those without diabetic retinopathy. The mean duration of diabetes mellitus in patients with shin spots was 14.88 years and it was 10.70 years in those without shin spots. CONCLUSIONS There is significant association between diabetic retinopathy and diabetic dermopathy. KEYWORDS Diabetic Retinopathy, Shin Spots, Diabetic Dermopathy
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6

Sirait, Erwin, Muhammad Zarlis, and Syahril Efendi. "Extraction Zoning Feature to Diabetic Retinopathic Detection Models." International Journal of Engineering & Technology 7, no. 3.2 (June 20, 2018): 786. http://dx.doi.org/10.14419/ijet.v7i3.2.18757.

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Анотація:
The health sector is one area that has been applying various computer technologies. To diagnose a patient's illness was already done with computers. One is to diagnose diabetic Retinopathic disease that can happen to anyone. Diabetic Retinopathy, which is one of the complications caused by diabetes. Symptoms shown from this disease is mikroneurisma, hemorrhages, excudets and neovascularos. The detection of the disease is done by looking at the information on the retinal image and can then be classified according to severity. This research aims to develop a method that can be used utuk classify Diabetic Retinopathy. The process of classification is based fiture-fiture the retinal image obtained by the extraction process using extraction methods Zoning. The process is then performed to classify the Bayes Method and the results obtained Diabetic Retinopahty classification. The results of this study yield maximum accuracy 65%.
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7

Ali, Farhan, and Syed Nishat Akram. "Frequency of Diabetic Retinopathy in Diabetic Patients in Pakistan." Journal of Contemporary Insights in Health Sciences 1, no. 1 (June 30, 2023): 23–29. http://dx.doi.org/10.69591/jcihs.v1i1.5.

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Анотація:
Objective: To determine the frequency of diabetic retinopathy and its types in diabetic patients of Pakistan. Study Design: cross sectional study. Place and duration: study was conducted in department of Ophthalmology, Nishtar Hospital Multan from 1st June 2020 to 2nd June 2021 in one-year duration. Methodology: Study was conducted on 300 diabetic patients and presented at the outpatient’s department of hospital. Refraction was done in all patients with the Snellen chart and fundus was examined with slit lamp or fundoscopy method. Main variables of study were diabetic retinopathy, macular edema, and types of diabetic retinopathy. Diabetic retinopathy was further divided into proliferating retinopathy, non-proliferating retinopathy (mild, moderate and sever) according to severity of DR. Results: Out of three hundred patients 65.0% were observed with diabetics’ retinopathy. Prevalence of macular edema in diabetics patients was 13.0%. The diabetic's patients were categories according to retinopathy severity; 28.3% had mild NPDR, 13.0% had moderate NPDR, 11.0% had severe NPDR and 7.7% had PDR. Conclusion: Diabetic retinopathy either proliferative or non-proliferative is highly prevalent in Pakistani population. Early detection and management are necessary to prevent its role in blindness.
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De Castro, Milena Borges, Vitoria Aguiar De Faria, Edilberto Vanconcelos Pereira Júnior, Izabela Aguiar De Faria, Iago Assunção Pereira, Cristiano De Anchieta Lisboa, and Virgílio Ribeiro Guedes. "Fatores de risco para retinopatia diabética: uma revisão." Revista de Patologia do Tocantins 4, no. 3 (September 26, 2017): 66. http://dx.doi.org/10.20873/uft.2446-6492.2017v4n3p66.

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Анотація:
Introdução: A retinopatia diabética é uma severa complicação recorrente do diabetes 1 e 2, afastá-la exige um acompanhamento médico enérgico e uma atenção principalmente para o controle de seus fatores de risco. Objetivo: Identificar fatores de risco para retinopatia diabética a partir de publicações recentes em base de dados diversas. Metodologia: Pesquisa retrospectiva, não-sistemática das bases de dados Lilacs, SciELO e Pubmed empregando os termos “retinopatia diabética”, “diabetes mellitus”, “fatores de risco”, “nefropatia diabética”, “glaucoma”, “catarata”, “miopia”, “controle glicêmico”, “hipertensão”, “dislipidemia”, “obesidade”, “gestação” e seus equivalentes em língua inglesa. Resultados: Os principais fatores de risco elegidos foram divididos em seções didáticas e explanados para melhor elucidação do tema. Conclusão: Fatores de risco para retinopatia diabética há algumas décadas são discutidos e avaliados em diversas pesquisas por diferentes regiões e mostram resultados confluentes em todo mundo. Palavras-chave: Diabetes Mellitus, Retinopatia diabética, Fatores de risco. ABSTRACT Introduction: Diabetic retinopathy is a severe recurrent complication of diabetes 1 and 2, moving it away requires vigorous medical monitoring and attention primarily to control of its risk factors. Objective: To identify risk factors for diabetic retinopathy from recent publications in a variety of databases. Methods: Non-systematic search of Lilacs, SciELO and Pubmed databases using the terms "diabetic retinopathy", "diabetes mellitus", "risk factors", "diabetic nephropathy", "glaucoma", "cataract", "myopia", "Glycemic control", "hypertension", "dyslipidemia", "obesity", "gestation" And their equivalents in English. Results: The main risk factors chosen were divided into didactic sections and explanations to better elucidate the theme. Conclusion: Risk factors for diabetic retinopathy for some decades are discussed and evaluated in several researches by different regions and show confluent results worldwide. Keywords: Diabetes Mellitus, Diabetic retinopathy, Risk factors.
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Agarwal, Swati, Rajiv Raman, Rani Padmaja Kumari, Himanshu Deshmukh, Pradeep G. Paul, Perumal Gnanamoorthy, Govindasamy Kumaramanickavel, and Tarun Sharma. "Diabetic Retinopathy in Type II Diabetics Detected by Targeted Screening Versus Newly Diagnosed in General Practice." Annals of the Academy of Medicine, Singapore 35, no. 8 (August 15, 2006): 531–35. http://dx.doi.org/10.47102/annals-acadmedsg.v35n8p531.

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Анотація:
Introduction: The aim of this study was to compare the occurrence of diabetic retinopathy in targeted screening diabetic patients (Group I) with newly diagnosed diabetic patients in general practice (Group II). Materials and Methods: This was an observational cross-sectional study. Data were obtained from 25,313 subjects who participated in the diabetic screening camps, and 128 newly diagnosed diabetes who presented to the diabetic retinopathy screening camps in general practice in rural and urban south India. The study variables were collected from all patients who underwent eye examination from the target screening detected diabetics [(n = 173) Group I] and those newly diagnosed in general practice [(n = 128) Group II]. The variations in prevalence of diabetic retinopathy and sight-threatening diabetic retinopathy in Group I and Group II and the factors affecting it were identified. Results: The occurrence of diabetic retinopathy was 6.35% (95% CI, 2.5-9.5) in Group I and 11.71% (95% CI, 5.6-16.4) in Group II. No significant difference was observed on occurrence of diabetic retinopathy, including sight-threatening retinopathy, in rural versus urban population and in Group I versus Group II. Patients diagnosed in general practice (Group II) with systolic blood pressure (BP) >140 were more likely to have retinopathy (P = 0.02). Conclusions: Diabetic retinopathy including sight-threatening complications was found at the time of diagnosis of diabetes in the targeted screening group as well as in newly diagnosed diabetics in the general practice group. Key words: Diabetes mellitus, Diabetic retinopathy, General practice, Screening
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Petrovič, Mojca Globočnik, Ines Cilenšek, and Daniel Petrovič. "Manganese Superoxide Dismutase Gene Polymorphism (V16A) is Associated with Diabetic Retinopathy in Slovene (Caucasians) Type 2 Diabetes Patients." Disease Markers 24, no. 1 (2008): 59–64. http://dx.doi.org/10.1155/2008/940703.

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Анотація:
Substantial data indicate that oxidative stress is involved in the development of diabetic retinopathy. Two candidate genes that affect the oxidative stress are manganese mitochondrial superoxide dismutase (Mn-SOD) and endothelial nitric oxide synthase (eNOS). The aim of the present study was to examine the role of the V16A polymorphism of the Mn-SOD gene and the 4a/b polymorphism of the eNOS gene in the development of diabetic retinopathy in Caucasians with type 2 diabetes.In this cross sectional case-control study 426 unrelated Slovene subjects (Caucasians) with type 2 diabetes mellitus were enrolled: 283 patients with diabetic retinopathy and the control group of 143 subjects with type 2 diabetes of duration of more than 10 years who had no clinical signs of diabetic retinopathy.A significantly higher frequency of the VV genotype of the V16A polymorphism of the Mn-SOD was found in patients with diabetic retinopathy compared to those without diabetic retinopathy (OR=2.1, 95% CI = 1.2–3.4;p= 0.006), whereas the 4a/b polymorphism of the eNOS gene failed to yield an association with diabetic retinopathy.We may conclude that the VV genotype of the V16A polymorphism of the Mn-SOD gene was associated with diabetic retinopathy in Caucasians with type 2 diabetes, therefore it might be used as a genetic marker of diabetic retinopathy in Caucasians.
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Більше джерел

Дисертації з теми "Diabetic retinopathy"

1

Loukovaara, Sirpa. "Diabetic retinopathy and pregnancy." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/loukovaara/.

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2

Dow, Courtney. "Dietary Factors, Type 2 Diabetes and Diabetic Retinopathy." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS380/document.

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Анотація:
Contexte : Le diabète de type 2 (DT2) constitue une pathologie majeure, au lourd fardeau, associ ée à de nombreuses complications, comme la rétinopathie diabétique (RD). Des facteurs modifiables, comme l’alimentation, ont déjà été identifiés pour le DT2 et la RD mais certains aspects de leurs rôles restent à préciser. Objectifs : Les objectifs de cette thèse étaient d’examiner le rôle de l’alimentation, en particulier la consommation d’acides gras (AGs), et des autres facteurs modifiables liés au mode de vie sur le risque de DT2 et de synthétiser, interpréter et analyser la relation entre l’alimentation et la RD. Résultats : Les résultats suggèrent que le rôle des AGs sur le risque de DT2 et de la RD pourrait être différent selon leur type, et même varier au sein d’un groupe comme les AG polyinsaturés (AGPI). Les résultats suggèrent aussi qu’une forte adhésion aux recommandations alimentaires n’est pas associée avec le développement d’un DT2, mais en revanche une forte adhérence aux autres recommandations de santé (concernant le tour de taille, l’activité physique et le statut tabagique) est fortement associée avec un moindre risque de DT2. On a montré qu’avoir un mode de vie sain aurait pu empêcher la survenue de plus de la moitié des cas de DT2. Conclusions : Cette thèse a permis de préciser l’importance et la complexité du rôle de l’alimentation dans le développement du DT2 et de la RD. Elle montre aussi l’impact des comportements sains dans la pathologie de DT2 et confirme que le DT2 est en grande partie, une maladie évitable. Les efforts devraient se focaliser sur la modification des comportements de santé à la fois dans la population générale et atteinte de DT2 et notamment encourager une alimentation modérée et variée
Background : Type 2 diabetes (T2D) presents a significant health burden that is associated with many complications, such as diabetic retinopathy (DR), that further burden people with diabetes. Modifiable risk factors, such as the diet, have been identified for both T2D and DR; yet certain aspects of the role of the diet remain unclear. Objectives : The main objectives of this thesis were therefore to examine the role and impact of the diet, and in particular, the consumption of fatty acids (FAs), and other modifiable behaviours on the risk of T2D and to summarize, interpret and analyze the relationship between the diet and DR using data from both the E3N and AusDiab cohort studies. Results : The results suggest that the role of FAs on the risk of T2D and DR may differ between and within subgroups, and by individual polyunsaturated fatty acids (PUFAs). The findings also suggest that strongly adhering to national dietary guidelines is not associated with the development of T2D, but strongly adhering to other recommendations for healthy behaviours (for waist circumference, physical activity and smoking) is strongly inversely associated with T2D. Modifiable behaviour could have prevented more than half of the cases of T2D. Conclusions : This work underlines the importance and the complexity of the role of the diet in the development of T2D and DR. It also illustrates the impact of healthy behaviour in the etiology of T2D and confirms that T2D is largely preventable. Efforts should focus on the modification of multiple healthy behaviours in populations, and promote diets that are moderate and widely varied
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Teng, Thomas Bart. "Vessel identification in diabetic retinopathy." Thesis, Bournemouth University, 2003. http://eprints.bournemouth.ac.uk/441/.

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Diabetic retinopathy is the single largest cause of sight loss and blindness in 18 to 65 year olds. Screening programs for the estimated one to six per- cent of the diabetic population have been demonstrated to be cost and sight saving, howeverthere are insufficient screening resources. Automatic screen-ing systems may help solve this resource short fall. This thesis reports on research into an aspect of automatic grading of diabetic retinopathy; namely the identification of the retinal blood vessels in fundus photographs. It de-velops two vessels segmentation strategies and assess their accuracies. A literature review of retinal vascular segmentation found few results, and indicated a need for further development. The two methods for vessel segmentation were investigated in this thesis are based on mathematical morphology and neural networks. Both methodologies are verified on independently labeled data from two institutions and results are presented that characterisethe trade off betweenthe ability to identify vesseland non-vessels data. These results are based on thirty five images with their retinal vessels labeled. Of these images over half had significant pathology and or image acquisition artifacts. The morphological segmentation used ten images from one dataset for development. The remaining images of this dataset and the entire set of 20 images from the seconddataset were then used to prospectively verify generaliastion. For the neural approach, the imageswere pooled and 26 randomly chosenimageswere usedin training whilst 9 were reserved for prospective validation. Assuming equal importance, or cost, for vessel and non-vessel classifications, the following results were obtained; using mathematical morphology 84% correct classification of vascular and non-vascular pixels was obtained in the first dataset. This increased to 89% correct for the second dataset. Using the pooled data the neural approach achieved 88% correct identification accuracy. The spread of accuracies observed varied. It was highest in the small initial dataset with 16 and 10 percent standard deviation in vascular and non-vascular cases respectively. The lowest variability was observed in the neural classification, with a standard deviation of 5% for both accuracies. The less tangible outcomes of the research raises the issueof the selection and subsequent distribution of the patterns for neural network training. Unfortunately this indication would require further labeling of precisely those cases that were felt to be the most difficult. I.e. the small vessels and border conditions between pathology and the retina. The more concrete, evidence based conclusions,characterise both the neural and the morphological methods over a range of operating points. Many of these operating points are comparable to the few results presented in the literature. The advantage of the author's approach lies in the neural method's consistent as well as accurate vascular classification.
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Hillman, Nicola Jane. "Hypertension and experimental diabetic retinopathy." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241987.

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Penishkevich, Ya I. "Pathophysiological mechanisms of diabetic retinopathy." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18637.

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Mohamed, Shaheeda. "Efficacy of intravitreal triamcinolone in diabetic macular edema." Thesis, View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38479114.

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Malaguarnera, Giulia Anna. "Diabetic retinopathy and Type 3 Diabetes Role of Homocysteine." Doctoral thesis, Università di Catania, 2015. http://hdl.handle.net/10761/3950.

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Homocysteine is a sulphur amino acid converted to methionine to a remethylation pathway and to cysteine via transulphuration patway. Its level in the blood increase with age and are associated with several pathologies: cancer, autoimmune disease, cardiovascular and neurodegenerative disorders. The present thesis has focused on the study of the relationship between elevated levels of homocysteine and the deficiency of his metabolites, focusing on folate, in the severity of diabetic retinopathy (non- proliferative and proliferative). Then it had been investigated whether retinal Hcy is associated with retinal neurodegeneration. Histopathological, molecular, and biochemical abnormalities have commonalities in Diabetes and Alzheimer s Disease (AD), which has lead to AD recently termed as "Type 3 Diabetes". Therefore, the present study has focused to evaluate the role of homocysteine in animal models of Type 2 Diabetes (Goto-Kakizaki (GK) rats) and Alzheimer Disease (TASTPM transgenic mice).
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MALAGUARNERA, GIULIA ANNA MARIA. "Diabetic retinopathy and Type 3 Diabetes Role of Homocysteine." Doctoral thesis, Università degli studi di Catania, 2015. http://hdl.handle.net/20.500.11769/490906.

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Homocysteine is a sulphur amino acid converted to methionine to a remethylation pathway and to cysteine via transulphuration patway. Its level in the blood increase with age and are associated with several pathologies: cancer, autoimmune disease, cardiovascular and neurodegenerative disorders. The present thesis has focused on the study of the relationship between elevated levels of homocysteine and the deficiency of his metabolites, focusing on folate, in the severity of diabetic retinopathy (non- proliferative and proliferative). Then it had been investigated whether retinal Hcy is associated with retinal neurodegeneration. Histopathological, molecular, and biochemical abnormalities have commonalities in Diabetes and Alzheimer s Disease (AD), which has lead to AD recently termed as "Type 3 Diabetes". Therefore, the present study has focused to evaluate the role of homocysteine in animal models of Type 2 Diabetes (Goto-Kakizaki (GK) rats) and Alzheimer Disease (TASTPM transgenic mice).
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De, la Torre Gallart Jordi. "Diabetic Retinopathy Classification and Interpretation using Deep Learning Techniques." Doctoral thesis, Universitat Rovira i Virgili, 2019. http://hdl.handle.net/10803/667077.

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La retinopatia diabètica és una malaltia crònica i una de les principals causes de ceguesa i discapacitat visual en els pacients diabètics. L'examen ocular a través d'imatges de la retina és utilitzat pels metges per detectar les lesions relacionades amb aquesta malaltia. En aquesta tesi, explorem diferents mètodes innovadors per a la classificació automàtica del grau de malaltia utilitzant imatges del fons d'ull. Per a aquest propòsit, explorem mètodes basats en l'extracció i classificació automàtica, basades en xarxes neuronals profundes. A més, dissenyem un nou mètode per a la interpretació dels resultats. El model està concebut de manera modular per a que pugui ser utilitzat en d'altres xarxes i dominis de classificació. Demostrem experimentalment que el nostre model d'interpretació és capaç de detectar lesions de retina a la imatge únicament a partir de la informació de classificació. A més, proposem un mètode per comprimir la representació interna de la informació de la xarxa. El mètode es basa en una anàlisi de components independents sobre la informació del vector d'atributs intern de la xarxa generat pel model per a cada imatge. Usant el nostre mètode d'interpretació esmentat anteriorment també és possible visualitzar aquests components en la imatge. Finalment, presentem una aplicació experimental del nostre millor model per classificar imatges de retina d'una població diferent, concretament de l'Hospital de Reus. Els mètodes proposats arriben al nivell de rendiment de l'oftalmòleg i són capaços d'identificar amb gran detall les lesions presents en les imatges, que es dedueixen només de la informació de classificació de la imatge.
La retinopatía diabética es una enfermedad crónica y una de las principales causas de ceguera y discapacidad visual en los pacientes diabéticos. El examen ocular a través de imágenes de la retina es utilizado por los médicos para detectar las lesiones relacionadas con esta enfermedad. En esta tesis, exploramos diferentes métodos novedosos para la clasificación automática del grado de enfermedad utilizando imágenes del fondo de la retina. Para este propósito, exploramos métodos basados en la extracción y clasificación automática, basadas en redes neuronales profundas. Además, diseñamos un nuevo método para la interpretación de los resultados. El modelo está concebido de manera modular para que pueda ser utilizado utilizando otras redes y dominios de clasificación. Demostramos experimentalmente que nuestro modelo de interpretación es capaz de detectar lesiones de retina en la imagen únicamente a partir de la información de clasificación. Además, proponemos un método para comprimir la representación interna de la información de la red. El método se basa en un análisis de componentes independientes sobre la información del vector de atributos interno de la red generado por el modelo para cada imagen. Usando nuestro método de interpretación mencionado anteriormente también es posible visualizar dichos componentes en la imagen. Finalmente, presentamos una aplicación experimental de nuestro mejor modelo para clasificar imágenes de retina de una población diferente, concretamente del Hospital de Reus. Los métodos propuestos alcanzan el nivel de rendimiento del oftalmólogo y son capaces de identificar con gran detalle las lesiones presentes en las imágenes, que se deducen solo de la información de clasificación de la imagen.
Diabetic Retinopathy is a chronic disease and one of the main causes of blindness and visual impairment for diabetic patients. Eye screening through retinal images is used by physicians to detect the lesions related with this disease. In this thesis, we explore different novel methods for the automatic diabetic retinopathy disease grade classification using retina fundus images. For this purpose, we explore methods based in automatic feature extraction and classification, based on deep neural networks. Furthermore, as results reported by these models are difficult to interpret, we design a new method for results interpretation. The model is designed in a modular manner in order to generalize its possible application to other networks and classification domains. We experimentally demonstrate that our interpretation model is able to detect retina lesions in the image solely from the classification information. Additionally, we propose a method for compressing model feature-space information. The method is based on a independent component analysis over the disentangled feature space information generated by the model for each image and serves also for identifying the mathematically independent elements causing the disease. Using our previously mentioned interpretation method is also possible to visualize such components on the image. Finally, we present an experimental application of our best model for classifying retina images of a different population, concretely from the Hospital de Reus. The methods proposed, achieve ophthalmologist performance level and are able to identify with great detail lesions present on images, inferred only from image classification information.
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Heintz, Emelie. "Health economic aspects of diabetic retinopathy." Doctoral thesis, Linköpings universitet, Utvärdering och hälsoekonomi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76283.

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To ensure that the resources of the health care sector are used effectively, new technologies need to be evaluated before implementation to examine if they generate health outcomes at an acceptable cost. This information can be collected by performing health economic evaluations in which the costs and health outcomes of different technologies are compared. To estimate the effect on health care budgets, there is also a need for information about the prevalence of the specific disease. Health outcomes in health economic evaluations are often measured in quality-adjusted life years (QALYs), which are calculated by multiplying the remaining life years after an intervention by a weight representing the health-related quality of life (HRQoL) during those years. This thesis aims to provide deeper knowledge of the health economic aspects of diabetic retinopathy (DR), an eye complication that affects patients with diabetes and may in the worst case lead to blindness. The focus is on three empirical and two methodological health economic research questions. The empirical research areas cover prevalence, costs, and HRQoL related to patients with DR. The methodological research questions explore the performance of different methods for estimation of QALY weights. This is of interest since it has been argued that the most common methods for estimating QALY weights may not capture all relevant vision-related aspects of quality of life. The analyses comprehend the validity of different methods for estimating QALY weights among patients with DR and if the results of one of the specific methods for estimating QALY weights, the time trade-off (TTO) exercise, are affected by patients’ subjective life expectancy (SLE). The empirical results demonstrate that DR is seen in approximately 40% and 30% of patients with type I and type II diabetes respectively, indicating that the prevalence of DR has decreased in both of these patient groups. Healthcare costs vary considerably between different severity levels of the disease, being estimated at €26, €257, €216, and €433 per patient per year for background retinopathy, proliferative diabetic retinopathy (PDR), diabetic macular oedema (DMO), and PDR combined with DMO respectively. Blindness due to DR is associated with an increased use of transportation services, caregiving services, and assistive technologies as well as productivity losses. This suggests that preventing the progression of DR may lower healthcare costs. Patients with vision impairment due to DR have lowered HRQoL in various dimensions, but the diagnosis of DR in itself has only a limited effect on HRQoL. The results on the methodological research questions show that different methods for estimating QALY weights seem to give different results. In comparison to EQ-5D, the Health Utilities Index Mark 3 (HUI-3) is the most sensitive method for detecting differences in QALY weights due to DR, and if decisions are to be made based on values from the general public, it can be recommended for use in cost-utility analyses of interventions directed at DR. Neither of the direct methods, TTO and the visual analogue scale, seems to be sensitive to differences in visual function, and more research is needed concerning the role of vision in people’s responses to the TTO exercises. In TTO exercises with time frames based on actuarial life expectancy, the patients’ SLE has an effect on their willingness to trade off years for full health. Thus, applying time frames deviating from patients’ SLE may result in biased QALY weights. Such bias may appear stronger within patient populations than within the general public. In conclusion, this thesis offers estimates for prevalence, costs, and QALY weights that can be used in economic evaluations of interventions directed at DR and as benchmarks for future DR research in order to follow up consequences of changes in diabetes care. In addition, it demonstrates that the choice of method for estimating QALY weights may have an impact on whether an intervention is considered cost-effective.
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Книги з теми "Diabetic retinopathy"

1

Stewart, Michael W. Diabetic Retinopathy. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-3509-8.

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Duh, Elia J., ed. Diabetic Retinopathy. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-563-3.

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Browning, David J., ed. Diabetic Retinopathy. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-0-387-85900-2.

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4

Inc, ebrary, ed. Diabetic retinopathy. Hackensack, N.J: World Scientific, 2010.

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author, Labelle Pierre 1940, and David Frédérique 1971 author, eds. Diabetic retinopathy. Montréal, Québec: AP Annika Parance Publishing, 2013.

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6

J, Duh Elia, ed. Diabetic retinopathy. Totowa, N.J: Humana Press, 2008.

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7

J, Duh Elia, ed. Diabetic retinopathy. Totowa, N.J: Humana Press, 2008.

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8

E, Lang Gabriele, ed. Diabetic retinopathy. Basel: Karger, 2007.

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9

National Institutes of Health (U.S.), ed. Diabetic retinopathy. [Bethesda, Md.?]: U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, 1985.

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10

Liu, Guei-Sheung, and Jiang-Hui Wang, eds. Diabetic Retinopathy. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3255-0.

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Частини книг з теми "Diabetic retinopathy"

1

Stewart, Michael W. "Diabetes and Diabetic Retinopathy: Overview of a Worldwide Epidemic." In Diabetic Retinopathy, 1–27. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-3509-8_1.

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2

Meyerle, Catherine B., Emily Y. Chew, and Frederick L. Ferris. "Nonproliferative Diabetic Retinopathy." In Diabetic Retinopathy, 3–27. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-563-3_1.

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3

Pfister, Frederick, Yuxi Feng, and Hans-Peter Hammes. "Pericyte Loss in the Diabetic Retina." In Diabetic Retinopathy, 245–64. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-563-3_10.

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4

Kowluru, Renu A., and Pooi-See Chan. "Capillary Dropout in Diabetic Retinopathy." In Diabetic Retinopathy, 265–82. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-563-3_11.

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VanGuilder, Heather D., Thomas W. Gardner, and Alistair J. Barber. "Neuroglial Dysfunction in Diabetic Retinopathy." In Diabetic Retinopathy, 283–301. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-563-3_12.

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6

Swenarchuk, Lauren E., Linda E. Whetter, and Anthony P. Adamis. "The Role of Inflammation in the Pathophysiology of Diabetic Retinopathy." In Diabetic Retinopathy, 303–31. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-563-3_13.

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Antonetti, David A., Heather D. VanGuilder, and Cheng Mao-Lin. "Vascular Permeability in Diabetic Retinopathy." In Diabetic Retinopathy, 333–52. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-563-3_14.

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Duh, Elia J. "Retinal Neovascularization and the Role of VEGF." In Diabetic Retinopathy, 353–73. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-563-3_15.

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Das, Arup, Deepti Navaratna, and Paul G. McGuire. "Beyond VEGF – Other Factors Important in Retinal Neovascularization: Potential Targets in Proliferative Diabetic Retinopathy." In Diabetic Retinopathy, 375–98. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-563-3_16.

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Diana, V. Do, Julia A. Haller, Anthony P. Adamis, Striata Carla, Quan Dong Nguyen, Syed Mahmood Shah, and Antonia M. Joussen. "Anti-VEGF Therapy as an Emerging Treatment for Diabetic Retinopathy." In Diabetic Retinopathy, 401–22. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-563-3_17.

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Тези доповідей конференцій з теми "Diabetic retinopathy"

1

Palmowski, Anja M., Marcus A. Bearse, and Erich E. Sutter. "Multi-focal electroretinography in diabetic retinopathy." In Vision Science and its Applications. Washington, D.C.: Optica Publishing Group, 1996. http://dx.doi.org/10.1364/vsia.1996.thc.2.

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Diabetes mellitus (Dm) is a major cause of visual loss5 which may be prevented by good blood sugar control as well as timely retinal laser-photocoagulation. The mechanism of action of photocoagulation is not entirely clear yet. However destroying ischemic retinal areas is thought to reduce the production of angiogenic factors and thereby reduce neovascularizations and their complications. One problem is that the optimal time to induce laser treatment is often well before the diabetic patient is symptomatically affected. Even slitlamp examination does not always show signs of early retinopathy. Avascular retinal areas that may only be seen in fluorescein-angiography signify a 'point of no return' in the course of diabetic retinopathy6.
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R, Divya, and Sujitha R. "Detection Classification of Diabetic Retinopathy Using Deep Learning Neural Network." In The International Conference on scientific innovations in Science, Technology, and Management. International Journal of Advanced Trends in Engineering and Management, 2023. http://dx.doi.org/10.59544/zidj2950/ngcesi23p21.

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Diabetic Retinopathy (DR) is an eye condition that mainly affects individuals who have diabetes and is one of the important causes of blindness in adults. As the infection progresses, it may lead to permanent loss of vision. Diagnosing diabetic retinopathy manually with the help of an ophthalmologist has been a tedious and a very laborious procedure. This paper not only focuses on diabetic retinopathy detection but also on the analysis of different DR stages, which is performed with the help of Deep Learning (DL) and transfer learning algorithms. Diabetic Retinopathy (DR) is one of the leading causes of blindness for people who have diabetes in the world. Early detection of this disease can essentially decrease its effects on the patient. Dense Net are used on a huge dataset with around 3662 train images to automatically detect which stage DR has progressed. Five DR stages, which are 0 (No DR), 1 (Mild DR), 2 (Moderate), 3 (Severe) and 4 (Proliferative DR) are processed in the proposed work. It presented an AI based smart tele ophthalmology application for diagnosis of diabetic retinopathy. The app has the ability to facilitate the analyses of eye fundus images via deep learning from the Kaggle database using Tensor Flow mathematical library. The app would be useful in promoting health and timely treatment of diabetic retinopathy by clinicians.
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Sharanya, S., Arnav Vinod Rai, and Sai Vedanth. "Diabetic Retinopathy Detection." In 2024 4th International Conference on Data Engineering and Communication Systems (ICDECS). IEEE, 2024. http://dx.doi.org/10.1109/icdecs59733.2023.10502783.

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4

Bravo, María A., and Pablo A. Arbeláez. "Automatic diabetic retinopathy classification." In 13th International Symposium on Medical Information Processing and Analysis, edited by Jorge Brieva, Juan David García, Natasha Lepore, and Eduardo Romero. SPIE, 2017. http://dx.doi.org/10.1117/12.2285939.

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Adithya, P., Yellina Satya Subhash, and G. Divya. "Detection of Diabetic Retinopathy." In International Conference on Recent Trends in Data Science and its Applications (ICRTDA 2023). Denmark: River Publishers, 2023. http://dx.doi.org/10.13052/rp-9788770040723.125.

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Toresa, Dafwen, Hazlyna Harun, Juhaida bakar, and Nur Hasan. "Diabetic Retinopathy Tracker System." In International Conference on Advanced Information Scientific Development. SCITEPRESS - Science and Technology Publications, 2023. http://dx.doi.org/10.5220/0012446600003848.

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Sugathan, Divya, Harshitha R, H. V. Rajath, Gnanendra Kumar H, and Ganavi M. "Diabetic Retinopathy Using AI." In 2023 7th International Conference on Design Innovation for 3 Cs Compute Communicate Control (ICDI3C). IEEE, 2023. http://dx.doi.org/10.1109/icdi3c61568.2023.00017.

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Kaur, Simran, and Barjinder Singh Saini. "An Evaluation Based on Diabetic Retinopathy." In International Conference on Women Researchers in Electronics and Computing. AIJR Publisher, 2021. http://dx.doi.org/10.21467/proceedings.114.24.

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Diabetic retinopathy is a globally rising disease and needs to be taken in concern. It is the problem with vision of diabetic patients due to a disease in the retina of diabetic patients.Diabetic patients have high glucose level in the blood.Our major concern is to predict the disease at early stages.The studies focusses on the modern techniques used in image processing digitally.It also puts a stress on patches classification used for the examination and prediction of diabetic retinopathy and judge the accuracy,senstivity of dataset.
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9

Schneck, Marilyn E., Brad Fortune, Michael Crognale, Eugene Switkes, and Anthony J. Adams. "Influence of blood glucose level on chromatic VEP's in Type I diabetes." In Vision Science and its Applications. Washington, D.C.: Optica Publishing Group, 1996. http://dx.doi.org/10.1364/vsia.1996.thc.1.

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In diabetes, changes in the function of the short-wavelength sensitive system (S-pathway) precede changes in more standard measures of visual function and may be observed prior to, or in the absence of, diabetic retinopathy (e.g. Adams, 1982; Zisman and Adams, 1982). Diabetes is fundamentally a metabolic disorder, characterized by elevated blood glucose. It is reasonable then, to consider the altered metabolic state of the diabetic as the underlying cause of the early loss of S-cone sensitivity. It has, however, proven difficult to separate metabolic from structural bases for the early vision loss, because l)the development of retinopathy is itself affected by metabolic control, and 2) vascular changes may be present though undetected in people with 'no retinopathy'.
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10

Custodi, P., G. P. Montecchio, C. Bendotti, G. Vandelli, M. T. Tenconi, and F. Piovella. "PLATELET FIBRONECTIN LEVELS AS A MARKER FOR THE PROGRESSION OF DIABETIC RETINOPATHY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643097.

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Aim of the study was to correlate fibronectin (Fn) and von Villebrand factor (vWf) levels measured in plasma and in platelets with the progression of diabetic retinopathy. Patients were classified in five groups reflecting the progression of this microvascular complication, on the basis of fluorangiographic findings (0 = no microangiopathy; 1= simple microangiopathy; 2= oedematous retinopathy; 3= ischaemic retinopathy; 4= ischaemic proliferative retinopathy). 43 patients were studied, 22 suffering from type I diabetes and 21 from type II diabetes, according to the classification of National Diabetes Data Group. Fn and vWf were measured in plasma and in platelet samples using an original double-sandwich microELISA method and expressed as micrograms/ml or as micrograms/10* platelets. Platelets were counted and solubilized with 0.5% Triton × 100. Bleeding time and platelet adhesion to glass beads were also evaluated on every patient. Intraplatelet Fn levels were reduced in retinopathies and correlate with the severity of the microvascular alteration, being the difference significant between the two extreme groups (p<0.05). vWf intraplatelet levels were also significantly lower in patients with severe microvascular complications (p<0.05). No significant differences were detected for plasma Fn and vWf levels in the 5 groups. Intraplatelet Fn and vWf levels may therefore be considered as markers of the severity of diabetic retinopathy. The leakage of Fn and vWf from activated platelet and the incorporation of these glycoproteins in the subendothelial matrix may be responsible for the worsening of this microvascular complication.
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Звіти організацій з теми "Diabetic retinopathy"

1

Ward, Thomas, and Robert Bauer. Teleophtalmology for Diabetic Retinopathy Screening. Fort Belvoir, VA: Defense Technical Information Center, September 2001. http://dx.doi.org/10.21236/ada405316.

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2

Li, Bin, Fei Wen, Hongru Chen, and Ri-Li Ge. A meta analysis of the prevalence rate of diabetic retinopathy. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2022. http://dx.doi.org/10.37766/inplasy2022.9.0112.

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Review question / Objective: P: diabetic retinopathy; I:—; C:—; O: prevalecne rate; S:cross-sectional study. Objective:To analyze the epidemiological characteristics of diabetic retinopathy and to provide scientific basis for its prevention and control． Condition being studied: Diabetic retinopathy is one of the common microvascular complications in patients with diabetes mellitus, which ultimately seriously affects the vision of patients. It is the leading cause of blindness among young and middle-aged workers worldwide. It is one of the main causes of binocular blindness in elderly patients in western countries.Because of the high incidence, wide range, complex pathogenesis, serious consequences and poor treatment effect of DM and its DR,many countries have actively carried out epidemiological research on the population of DM patients in order to understand the incidence, distribution and related risk factors of DR, and to provide scientific basis for the formulation of targeted public prevention and control measures.
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3

Li, Ting, Shudan Ge, Wei Zheng, Chao Luan, Xingtong Liu, Zongxiu Luo, Qi Zhao, and Lulu Xie. Effectiveness and safety of panretinal photocoagulation combined with intravitreous ranibizumab for patients with type 2 proliferative diabetic retinopathy：A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0048.

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Review question / Objective: Our study aims to synthesise results from randomised controlled trials to assess the effectiveness and safety of PRP combined with intravitreous ranibizumab for T2PDR. Condition being studied: Diabetic retinopathy (DR) is the most common complication of diabetes mellitus, which will seriously affect the quality of life of patients and bring great burden to patients’ families and society. DR is one of the most important diseases of blindness in people aged 20 to 60 years worldwide. Nearly 15% of diabetic patients with a disease duration of more than 5 years were combined with DR.The prevalence of vision threatening diabetic retinopathy in the United States is 4.4 percent. Worldwide, the prevalence is estimated at 10.2%.At present, the treatment methods for type 2 proliferative diabetic retinopathy (T2PDR), at home and abroad mainly include retinal laser photocoagulation and intravitreal injection of vascular endothelial growth factor (VEGF) inhibitors.
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4

Xu, Jiayu, Liyuan Wang, He Sun, and Hanli Wang. Effectivenes and safety of curcumin in diabetic retinopathy. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0002.

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5

Cooper, Amy, Lajerica Bates, Julie Bridges, and Laura Reed. Barriers to Screening for Diabetic Retinopathy: A Scoping Review. University of Tennessee Health Science Center, April 2023. http://dx.doi.org/10.21007/con.dnp.2023.0047.

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6

Wang, Wei, and Yi Wu. Prediction models for diabetic retinopathy development in type 2 diabetes mellitus patients: a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0089.

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7

dong, bixuan, Xiaowei Fan, and Bin Li. Association between Erythropoietin Polymorphisms and Diabetic Retinopathy Risk: A Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2024. http://dx.doi.org/10.37766/inplasy2024.5.0130.

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8

Fu, Shouqiang, Liwei Zhang, Xiaoyun Zhu, and Ximing Liu. Associating Abdominal Obesity with Diabetic Retinopathy in Patients with Diabetes Mellitus: Systematic Review and Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0091.

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9

Zhou, Yanni, Hui Li, Lisi Luo, Yue Chen, Qiang Chen, and Wei Bian. Acupoint injection therapy for diabetic retinopathy: a protocol for a systematic review and meta analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2020. http://dx.doi.org/10.37766/inplasy2020.11.0026.

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10

Liu, Jin, Youbin Ye, and Yawen Lin. Meta-analysis of the correlation between serum uric acid level and type 2 diabetic retinopathy. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2020. http://dx.doi.org/10.37766/inplasy2020.7.0111.

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