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Статті в журналах з теми "Découverte de nouvelles classes"
Royal, Perrine, Pablo Ávalos Prado, Brigitte Wdziekonski, and Guillaume Sandoz. "Canaux potassiques à deux domaines P (K2P) et migraine." Biologie Aujourd'hui 213, no. 1-2 (2019): 51–57. http://dx.doi.org/10.1051/jbio/2019020.
Повний текст джерелаLanoë, Céline, and Jérémie Blanchette Sarrasin. "Le cerveau enseigné aux élèves : des connaissances scientifiques à la mise en œuvre pédagogique." Neuroeducation 7, no. 1 (2021): 20–38. http://dx.doi.org/10.24046/neuroed.20210701.20.
Повний текст джерелаSzewczyk, Martin. "Nouveaux éléments pour l’étude d’un portrait de notable éphésien du musée du Louvre." Revue des Études Anciennes 117, no. 1 (2015): 129–51. http://dx.doi.org/10.3406/rea.2015.5917.
Повний текст джерелаFallahnejad, Naeimeh. "L’influence du théâtre français sur le théâtre persan moderne à la fin du XIXe siècle : le rôle des traductions et des traducteurs." ALTERNATIVE FRANCOPHONE 1, no. 8 (September 24, 2015): 86–99. http://dx.doi.org/10.29173/af25600.
Повний текст джерелаSaint-Joanis, Brigitte, and Roland Brosch. "Découverte d’une nouvelle classe d’antituberculeux : les benzothiazinones (BTZ)." médecine/sciences 25, no. 8-9 (August 2009): 663–65. http://dx.doi.org/10.1051/medsci/2009258-9663.
Повний текст джерелаVarinlioğlu, Ender. "Milestone." Revue des Études Anciennes 113, no. 1 (2011): 3–6. http://dx.doi.org/10.3406/rea.2011.6687.
Повний текст джерелаLeimus, Ivar. "On the Chronology of the Miliaresia of Basil II and Constantine VIII: an Estonian Perspective." Revue numismatique 6, no. 177 (2020): 235–45. http://dx.doi.org/10.3406/numi.2020.3485.
Повний текст джерелаKızıl, Abuzer, Patrice Brun, Laurent Capdetrey, Raymond Descat, Pierre Fröhlich, Koray Konuk, and Ignasi-Xavier Adiego. "Pidasa et Asandros : une nouvelle inscription (321/0)." Revue des Études Anciennes 117, no. 2 (2015): 371–409. http://dx.doi.org/10.3406/rea.2015.5933.
Повний текст джерелаCicikova, Maria, and Violeta Božilova. "Nouvelle inscription d'un sénateur anonyme découverte à Novae (Mésie Inférieure)." Mélanges de l’École française de Rome. Antiquité 102, no. 2 (1990): 611–19. http://dx.doi.org/10.3406/mefr.1990.1682.
Повний текст джерелаMihai Feraru, Remus. "Nouvelles contributions à l'étude des cadrans solaires découverts dans les cités grecques de Dobroudja." Dialogues d'histoire ancienne 34, no. 2 (2008): 65–80. http://dx.doi.org/10.3406/dha.2008.3079.
Повний текст джерелаДисертації з теми "Découverte de nouvelles classes"
Dao, Thi Mai Lan. "Découverte des nouvelles classes d'éléments cis-régulateurs par une approche gène-rapporteur à haut débit." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4036.
Повний текст джерелаThe initial step of gene expression is the transcription of genomic DNA of the gene into RNA. The transcription can only be initiated by the assembly of RNAPII machinery around transcription start site of a gene, known as core promoter. However, transcription also requires other gene-distal regulatory DNA regions, known as enhancers. Enhancers and promoters are traditionally distinguished by their histone modifications. Recently, there has been increasing number of studies revealing broad similarities between enhancers and promoters. Previous findings have suggested the possibility that some gene promoters display enhancer activity. However, the questions of how can we identify this type of promoter in genome-wide and whether they actually function to regulated the expression of distal genes are remained elusive.My project has carried out aiming to answer these above questions. Firstly, I have optimized the technique that has developed in the lab, named CapStarr-seq, which used as an approach to exploiting a high-throughput enhancer activity. Performing CapStarr-seq in human cell lines, I unraveled an underestimated proportion of promoter displaying enhancer activity, defined as Epromoters. They display distinct properties as compared to distal enhancers and classical promoters, are associated with stress response genes and interact more frequently with other promoters. Moreover, by using comprehensive CRISPR/Cas9 genomic deletion approach, I demonstrated that Epromoters are generally involved in the activation of distal genes. Taken together, our results first identify a new category of promoters with dual promoter and enhancer functions
Troisemaine, Colin. "Novel class discovery in tabular data : an application to network fault diagnosis." Electronic Thesis or Diss., Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire, 2024. http://www.theses.fr/2024IMTA0422.
Повний текст джерелаThis thesis focuses on Novel Class Discovery (NCD) in the context of tabular data. The Novel Class Discovery problem consists in extracting knowledge from a labeled set of already known classes in order to more accurately partition an unlabeled set of new classes. Although NCD has recently received a lot of of attention from the community, it is generally addressed in computer vision problems and sometimes under unrealistic conditions. In particular, the number of novel classes is often assumed to be known in advance, and their labels are sometimes used to tune hyperparameters. Methods based on these assumptions are not applicable to realworld scenarios. Thus, in this thesis we focus on discovery resolution in tabular data when no a priori knowledge is available. The methods developed in the thesis are applied to a real-world case: automatic fault diagnosis in telecommunication networks, with a focus on fiber optic access networks. The aim is to achieve efficient fault management, particularly at the diagnosis stage when unknown faults (new classes) may appear
Forest, Jason. "Caractérisation de classes par la découverte automatique de sous-classes." Paris 6, 2009. http://www.theses.fr/2009PA066261.
Повний текст джерелаLarsabal, Etienne. "Découverte des motifs souples de classe A : une nouvelle classe de sites d' interaction ADN-protéines chez les procaryotes et eucaryotes inférieurs." Paris 6, 2005. http://www.theses.fr/2005PA066216.
Повний текст джерелаBéghyn, Terence. "Activité antiplasmodiale de nouvelles tétrahydro-β-carbolines chirales : découverte et optimisation". Lille 2, 2006. http://www.theses.fr/2006LIL2S044.
Повний текст джерелаJacry, Cécile. "Découverte de nouvelles molécules antibiotiques et caractérisation de leurs modes d'action." Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPASL009.
Повний текст джерелаFlavonoids are secondary metabolites widespread in plants and belong to a large family of chemical compounds of industrial interest. Flavonoids are an important source of new drugs and nutraceuticals because of their antioxidant, antiviral, antimicrobial, anticancer activities. Our study focuses on the characterization of the antibacterial activity of flavonoids specifically targeting Gram-positive bacteria. The objectives of my research work are i) to establish efficient and rapid screening methodologies to evaluate the antibacterial activity of flavonoids and ii) to determine the mechanisms of action of antibacterial flavonoids. The characterization of the antibacterial activity of flavonoids was carried out with flavonoid toxicity tests against the Gram-positive model bacterium B. subtilis by Live Cell Array method, which measures the bacterial growth kinetics. Several strategies were used to decipher the mode(s) of action of the flavonoids, such as screening a flavonoid library for new compounds active against B. subtilis, screening a collection of B. subtilis mutants for the identification of genes involved in the flavonoid response of B. subtilis, an adaptive laboratory evolution of B. subtilis in presence of flavonoid to obtain and characterize flavonoid-resistant strains, and finally an analysis of the transcriptional response of B. subtilis in the presence of flavonoids. Two flavonoids already identified in the literature to inhibit the growth of Gram-positive bacteria, pinocembrin and naringenin, have antibacterial activity against B. subtilis. A 50% decrease in growth rate was observed in the presence of 93 mg.L ⁻¹ or 32 mg.L ⁻¹ of naringenin or pinocembrin respectively.To decipher the mechanisms of action of the flavonoids, a collection of 63 flavonoids was screened and minimal inhibitory concentrations (MICs) were determined for each flavonoid in the presence of B. subtilis. 17 flavonoids were found to be particularly active against B. subtilis. The attempt to establish a QSAR (quantitative structure activity relationship) model with the 17 active flavonoids was unfortunately not conclusive because, despite obtaining a high quality linear regression (R² ≈ 0.9), cross-validation by using leave-one-out basic method was not obtained. The only plausible explanation for this failure is that the number of modes of action present is too high for a set of 17 compounds, thus rendering the QSAR model obsolete. In a screen of 67 mutants of B. subtilis, eight genes involved in the response to flavonoids (naringenin and pinocembrin) were identified, two of which belong to the LmrA/QdoR regulon, already identified in the literature to respond to flavonoids. The B. subtilis strains ∆lmrA and ∆qdoI are respectively more sensitive and more resistant to naringenin and pinocembrin. The 17 flavonoids previously identified and active against B. subtilis induce a flavonoid-specific transcriptional response according to our analysis of the activity of 10 promoters with the use of transcriptional fusions with a reporter gene. This analysis is consistent with the transcriptomic study carried out for the characterization of the response of B. subtilis in the presence of 5 flavonoids; 2'hydroxyflavanone, bavachine, naringenin, pinocembrin and resokaempferol. Several modes of action of the flavonoids in B. subtilis were identified, involving induction of the stringent response, inhibition of metabolic pathways for cell membrane and cell wall synthesis, and inhibition of central carbon metabolism
Chocu, Sophie. "Découverte de nouvelles protéines impliquées dans la spermatogenèse chez le rat." Thesis, Rennes 1, 2014. http://www.theses.fr/2014REN1S064/document.
Повний текст джерелаSpermatogenesis in mammals is a complex biological function including cellular processes such as proliferation, meiosis and differentiation, aiming to the production of male gametes in the testis. If the seminiferous epithelium is well described in terms of organization and cellular morphology of cells that compose it, the processes by which undifferentiated diploid germ cells enter meiosis and give haploid cells that undergo many morphological transformations, are not fully decrypted. These processes rely on the coordinated and sequential expression of genes, including specific products for each stage of germ cell development These gene products are essential at each key stage of spermatogenesis. Transcriptomics since the 1990s, and proteomics since the 2000s have contributed to the improved. understanding of these mechanisms. A long term proteomic study aiming at characterizing the proteomes of Sertoli cells and germ cells, and a recent study that characterized and quantified the transcriptome of isolated rat testicular cells at high resolution using de novo sequencing of transcripts (RNA-Seq), have been the basis of my thesis work. The latter study showed the accumulation of long non-Coding RNAs (lncRNAs) and testicular unannotated transcripts (TUTs) at meiotic and post-Meiotic stages of spermatogenesis in the rat. In this context, my thesis work aimed at validating the coding potential of many genes expressed in germ cells using RNA-Seq combined with shotgun proteomics, a so-Called PIT (Proteomics Informed by transcriptomics) approach. In this approach, the protein sequences translated from the transcripts assembled by RNA-Seq in the different testicular cell types are integrated into a custom database of protein sequences used to query mass spectrometry data obtained from proteins of meiotic and post-Meiotic cells. The PIT approach showed that 69 TUTs or lncRNA (corresponding to 44 loci) code for proteins in meiotic cells and post meiotic cells, and we confirmed experimentally the meiotic and post-Meiotic expression for two new transcripts encoding for VAMP9, a protein of the SNARE family, and a new testicular enolase T-ENOL. The post-Meiotic expression of T-ENOL protein was confirmed by immunohistochemistry using a polyclonal antibody raised against the recombinant protein. This approach also allowed us to identify new isoforms of known proteins, specific to each stage of spermatogenesis. Germ cells and Sertoli cells maintain a dialogue which is necessary to the success of spermatogenesis and spermiogenesis. Another part of my work aimed at identifying membrane proteins, in germ cells and residual bodies, that may be involved in the dialogue between Sertoli cells and germ cells, using a ICPL relative quantification proteomic approach. The ICPL analysis enabled us to establish a list of 166 proteins whose expression is differential between pachytene spermatocytes, round spermatids and residual bodies. Their differential expression suggests that these proteins may play a role in spermiogenesis. Thanks to the Gene Ontology annotations, a list of 8 proteins with a putative role in signal transduction, cell recognition or differentiation, thus potentially involved in the dialogue between Sertoli and germ cells was drawn. In addition, I provided a first proteome of rat Sertoli cells, germ cells and residual bodies obtained by shotgun proteomics
Munier, Pascal. "Synthèses et propriétés de nouvelles classes d'osides." Lyon 1, 1994. http://www.theses.fr/1994LYO10284.
Повний текст джерелаBastien-Uluis, Geraldine. "Découverte de nouvelles enzymes de dégradation des polysaccharides végétaux par métagénomique fonctionnelle." Thesis, Toulouse, INSA, 2012. http://www.theses.fr/2012ISAT0005.
Повний текст джерелаA functional metagenomics approach was used to reveal the enzymatic diversity present in the guts of biomass-feeding termites and to identify enzymes involved in the degradation of biomass components, notably heteroxylans. High-throughput screening of metagenomic libraries, created using three different termite species, was performed using a variety of chromogenic substrates. This allowed the discovery of hundreds of clones expressing targeted biomass-degrading activities (e.g. depolymerases such as glucanase, xylanase, mannanase arabinanase and auxiliary activities such as α-L-arabinofuranosidases, β-D-xylosidases and cellobiohydrolases). A total of 42 clones were selected for a DNA sequence analysis, thus generating 1.5 Mbp that were assembled into 58 contiguous sequences. 63 new Glycoside Hydrolases (GH) belonging to 19 different families of the CAZy classification were identified, including ones from families GH3, GH8, GH10, GH11, GH43 and GH51. Finally, eight new enzymes, from families GH43 and GH51, were produced in E. coli and their biochemical properties were studied. These enzymes display α-L-arabinofuranosidase, β-D-xylosidase or arabinanase activities
Ghemtio, Leo. "Simulation numérique et approche orientée connaissance pour la découverte de nouvelles molécules thérapeutiques." Phd thesis, Université Henri Poincaré - Nancy I, 2010. http://tel.archives-ouvertes.fr/tel-00609018.
Повний текст джерелаКниги з теми "Découverte de nouvelles classes"
Eric, Maurin, ed. Les nouvelles classes moyennes. [Paris]: Seuil, 2012.
Знайти повний текст джерелаJean, Lojkine, Cours-Salies Pierre, Vakaloulis Michel, and International Marx Congress (4th : 2004), eds. Nouvelles luttes de classes. Paris: Presses universitaires de France, 2006.
Знайти повний текст джерелаHélène, Gervais, and Ottawa Board of Education, eds. À la découverte de ma région: Pour les classes d'immersion en français-niveau 9. Ottawa: Conseil scolaire d'Ottawa, 1993.
Знайти повний текст джерелаFillion, Pierre. Découverte de la dynamique de l'entreprise: Vision globale et mondialisation. 2nd ed. Sainte-Foy: Éditions Avantage, 2004.
Знайти повний текст джерелаHélène, Gervais, and Ottawa Board of Education, eds. À la découverte du moi: Document du professeur pour les classes d'immersion en français, niveau 9. Ottawa: Conseil scolaire d'Ottawa, 1993.
Знайти повний текст джерелаMichel, Pialoux, ed. Violences urbaines, violence sociale: Genèse des nouvelles classes dangereuses. Paris: Fayard, 2003.
Знайти повний текст джерелаOliver, Mireille. Les nouvelles routes du sel: À la découverte des marais salants, salins et salines. Rennes: Ouest-France, 2010.
Знайти повний текст джерелаTarrius, Alain. Les fourmis d'Europe: Migrants riches, migrants pauvres et nouvelles villes internationales. Paris: L'Harmattan, 1992.
Знайти повний текст джерелаGombert, Philippe. L'école et ses stratèges: Les pratiques éducatives des nouvelles classes supérieures. Rennes: Presses universitaires de Rennes, 2008.
Знайти повний текст джерелаauthor, Penissat Étienne, and Spire Alexis author, eds. Les classes sociales en Europe: Tableau des nouvelles inégalités sur le vieux continent. Marseille: Agone, 2017.
Знайти повний текст джерелаЧастини книг з теми "Découverte de nouvelles classes"
Carrier, Martin. "L'imaginaire et l'intuition dans les sciences." In L'imaginaire et l'intuition dans les sciences, 97–112. Hermann, 2009. http://dx.doi.org/10.3917/herm.buser.2009.01.0097.
Повний текст джерелаBellien, J., V. Richard, L. Monassier, T. Bejan-Angoulvant, and D. Angoulvant. "Nouvelles classes pharmacologiques." In Pharmacologie Cardio-Vasculaire et Respiratoire, 219–26. Elsevier, 2016. http://dx.doi.org/10.1016/b978-2-294-75159-2.00026-9.
Повний текст джерелаWidlöcher, Daniel. "IX. Une logique de la découverte." In Les Nouvelles Cartes de la psychanalyse, 193–208. Odile Jacob, 1996. http://dx.doi.org/10.3917/oj.widlo.1996.01.0193.
Повний текст джерелаGroux, Guy. "16. Des « classes moyennes » aux « nouvelles classes »." In Cadres : la grande rupture, 303–13. La Découverte, 2001. http://dx.doi.org/10.3917/dec.bouff.2001.01.0303.
Повний текст джерелаBonhomme, Éric. "« Couches nouvelles » et classes moyennes." In Les territoires du politique, 149–56. Presses universitaires de Rennes, 2012. http://dx.doi.org/10.4000/books.pur.133869.
Повний текст джерелаR. INVERNÓN, Vanessa, Romane TISSERAND, Pierre JOUANNAIS, Dulce M. NAVARRETE GUTIÉRREZ, Serge MULLER, Yohan PILLON, Guillaume ECHEVARRIA, and Sylvain MERLOT. "La découverte de nouvelles espèces végétales hyperaccumulatrices de métaux dans les herbiers." In Les collections naturalistes dans la science du XXIe siècle, 85–100. ISTE Group, 2021. http://dx.doi.org/10.51926/iste.9049.ch6.
Повний текст джерелаBOMBARD, Sophie, Patrick MAILLIET, and Marie-Paule TEULADE-FICHOU. "Agents ciblant les télomères." In Les télomères, 323–65. ISTE Group, 2024. http://dx.doi.org/10.51926/iste.9097.ch13.
Повний текст джерелаYUN-ROGER, Soyoung. "Les temporalités dans les télécollaborations entre classes de langues étrangères." In Numérique et didactique des langues et cultures, 55–64. Editions des archives contemporaines, 2022. http://dx.doi.org/10.17184/eac.5801.
Повний текст джерелаBouix-Peter, Claire. "La découverte de nouvelles solutions thérapeutiques pour le traitement de pathologies de la peau." In Chimie, dermo-cosmétique et beauté, 129–48. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-2078-8-009.
Повний текст джерелаBouix-Peter, Claire. "La découverte de nouvelles solutions thérapeutiques pour le traitement de pathologies de la peau." In Chimie, dermo-cosmétique et beauté, 129–48. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-2078-8.c009.
Повний текст джерелаЗвіти організацій з теми "Découverte de nouvelles classes"
Rousseau, Henri-Paul. Gutenberg, L’université et le défi numérique. CIRANO, December 2022. http://dx.doi.org/10.54932/wodt6646.
Повний текст джерела